Tsc2 (TSC complex subunit 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tsc2 (TSC complex subunit 2) Heterocephalus glaber
Analyze
Symbol: Tsc2
Name: TSC complex subunit 2
RGD ID: 18927762
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); GTPase activator activity (ortholog); Hsp90 protein binding (ortholog); INVOLVED IN anoikis (ortholog); B cell proliferation (ortholog); cell population proliferation (ortholog); PARTICIPATES IN mitogen activated protein kinase signaling pathway; mTOR signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH Acute Hepatitis (ortholog); acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); FOUND IN caveola (ortholog); cell projection (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tuberin; tuberous sclerosis 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913166,931 - 202,953 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-RatAcute Hepatitis  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:20033472 and REF_RGD_ID:11568659
Tsc2Naked Mole-RatAlzheimer's disease  ISOTSC2 (Homo sapiens)9068941 RGDPMID:16341938 and REF_RGD_ID:1580518
Tsc2Naked Mole-Ratangiomyolipoma  ISOTSC2 (Homo sapiens)9068941associated with Tuberous Sclerosis more ...RGDPMID:19265534 and REF_RGD_ID:8657154
Tsc2Naked Mole-Ratbreast cancer disease_progressionISOTSC2 (Homo sapiens)9068941mRNA and protein:decreased expression:breastRGDPMID:15951164 and REF_RGD_ID:11568707
Tsc2Naked Mole-RatExperimental Diabetes Mellitus  ISOTsc2 (Rattus norvegicus)9068941protein:increased threonine phosphorylation:cortex of kidney RGDPMID:18599524 and REF_RGD_ID:8657153
Tsc2Naked Mole-RatFemale Infertility  ISOTsc2 (Mus musculus)9068941 RGDPMID:25189766 and REF_RGD_ID:11568667
Tsc2Naked Mole-Rathemangioma  ISOTsc2 (Mus musculus)9068941 RGDPMID:10096549 and REF_RGD_ID:11568655
Tsc2Naked Mole-Rathepatic angiomyolipoma  ISOTsc2 (Rattus norvegicus)9068941associated with tuberous sclerosis and DNA:mutations:multipleRGDPMID:22251200 and REF_RGD_ID:21079732
Tsc2Naked Mole-Rathepatic angiomyolipoma  ISOTsc2 (Mus musculus)9068941DNA:mutations:multipleRGDPMID:29512829 and REF_RGD_ID:21079730
Tsc2Naked Mole-Rathepatic angiomyolipoma  ISOTSC2 (Homo sapiens)9068941associated with tuberous sclerosis and DNA:mutations:multipleRGDPMID:22251200 and REF_RGD_ID:21079732
Tsc2Naked Mole-Rathepatic angiomyolipoma  ISOTSC2 (Homo sapiens)9068941DNA:mutations:multipleRGDPMID:29512829 and REF_RGD_ID:21079730
Tsc2Naked Mole-Rathepatic angiomyolipoma  ISOTsc2 (Rattus norvegicus)9068941DNA:mutations:multipleRGDPMID:29512829 and REF_RGD_ID:21079730
Tsc2Naked Mole-Rathepatic angiomyolipoma  ISOTsc2 (Mus musculus)9068941associated with tuberous sclerosis and DNA:mutations:multipleRGDPMID:22251200 and REF_RGD_ID:21079732
Tsc2Naked Mole-Rathepatocellular carcinoma severityISOTSC2 (Homo sapiens)9068941protein:decreased expression:liver (human)RGDPMID:24119083 and REF_RGD_ID:21079731
Tsc2Naked Mole-Rathepatocellular carcinoma severityISOTsc2 (Mus musculus)9068941protein:decreased expression:liver (human)RGDPMID:24119083 and REF_RGD_ID:21079731
Tsc2Naked Mole-Rathepatocellular carcinoma severityISOTsc2 (Rattus norvegicus)9068941protein:decreased expression:liver (human)RGDPMID:24119083 and REF_RGD_ID:21079731
Tsc2Naked Mole-Ratleiomyoma  ISOTSC2 (Homo sapiens)9068941 RGDPMID:21145542 and REF_RGD_ID:11568684
Tsc2Naked Mole-RatLymphatic Metastasis  ISOTSC2 (Homo sapiens)9068941associated with Breast NeoplasmsRGDPMID:15951164 and REF_RGD_ID:11568707
Tsc2Naked Mole-Ratmedulloblastoma  ISOTSC2 (Homo sapiens)9068941DNA:polymorphism:intronRGDPMID:11603814 and REF_RGD_ID:11072879
Tsc2Naked Mole-Ratpancreatic ductal carcinoma severityISOTSC2 (Homo sapiens)9068941 RGDPMID:16213898 and REF_RGD_ID:11568674
1 to 20 of 23 rows
1 to 20 of 51 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-RatArthralgia  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: ArthralgiaClinVarPMID:25741868 more ...
Tsc2Naked Mole-Ratastroblastoma, MN1-altered  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Astroblastoma and MN1-alteredClinVarPMID:25741868 and PMID:28492532
Tsc2Naked Mole-Ratautism spectrum disorder  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15024740 more ...
Tsc2Naked Mole-Ratautosomal dominant polycystic kidney disease  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant polycystic kidney diseaseClinVarPMID:21115670 more ...
Tsc2Naked Mole-Ratbone osteosarcoma  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Bone osteosarcomaClinVarPMID:25741868 and PMID:26822237
Tsc2Naked Mole-RatBrain Neoplasms  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neoplasm of brainClinVarPMID:10205261 more ...
Tsc2Naked Mole-RatCafe-au-Lait Spots  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cafe-au-lait spotClinVarPMID:25741868 more ...
Tsc2Naked Mole-Ratcystic fibrosis  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cystic fibrosisClinVarPMID:25741868
Tsc2Naked Mole-Ratdevelopmental and epileptic encephalopathy 1  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 1ClinVarPMID:28492532 and PMID:30866059
Tsc2Naked Mole-Ratendometrial carcinoma  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Endometrial carcinomaClinVar 
Tsc2Naked Mole-Ratepilepsy  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17304050 more ...
Tsc2Naked Mole-Ratfamilial adenomatous polyposis 3  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: NTHL1-related conditionClinVarPMID:25741868 and PMID:28492532
Tsc2Naked Mole-RatFever  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Episodic feverClinVarPMID:28492532
Tsc2Naked Mole-RatFocal Cortical Dysplasia of Taylor  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10205261 more ...
Tsc2Naked Mole-RatHamartoma  ISOTSC2 (Homo sapiens)8554872ClinVar Annotator: match by term: HamartomaClinVarPMID:25741868
Tsc2Naked Mole-RatHereditary Neoplastic Syndromes  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc2Naked Mole-RatHereditary Neoplastic Syndromes  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc2Naked Mole-RatHereditary Neoplastic Syndromes  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc2Naked Mole-RatHereditary Neoplastic Syndromes  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc2Naked Mole-RatHereditary Neoplastic Syndromes  ISOTSC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
1 to 20 of 51 rows
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-Ratacute myeloid leukemia  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19250671
Tsc2Naked Mole-Ratautistic disorder  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:14627686
Tsc2Naked Mole-Ratbrain disease  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21062901
Tsc2Naked Mole-RatInflammation  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26297436
Tsc2Naked Mole-RatKidney Neoplasms  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11170505 more ...
Tsc2Naked Mole-Ratleiomyoma  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15937110
Tsc2Naked Mole-RatLung Neoplasms  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30008631
Tsc2Naked Mole-RatMouth Neoplasms  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18538015
Tsc2Naked Mole-RatNerve Degeneration  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21419848
Tsc2Naked Mole-Ratpancreatic cancer  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19917848
Tsc2Naked Mole-Ratpre-malignant neoplasm  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26297436
Tsc2Naked Mole-Ratsquamous cell carcinoma  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18538015
Tsc2Naked Mole-RatWest syndrome  ISOTSC2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18345974
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-Ratuterine fibroid  ISOTsc2 (Mus musculus)9068941OMIM:150699MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-RatFocal Cortical Dysplasia of Taylor  ISOTSC2 (Homo sapiens)7240710 OMIM 
Tsc2Naked Mole-Ratlymphangioleiomyomatosis  ISOTSC2 (Homo sapiens)7240710 OMIM 
Tsc2Naked Mole-Rattuberous sclerosis 2  ISOTSC2 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 73 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-Ratanoikis involved_inISOUniProtKB:Q610379068941 PMID:23778976ParkinsonsUK-UCLPMID:23778976
Tsc2Naked Mole-Ratanoikis involved_inISOTsc2 (Mus musculus)9068941 PMID:23778976ParkinsonsUK-UCLPMID:23778976
Tsc2Naked Mole-RatB cell proliferation acts_upstream_ofISOMGI:1095839068941 PMID:16027169MGIPMID:16027169
Tsc2Naked Mole-Ratcell population proliferation acts_upstream_ofISOMGI:1095839068941 PMID:16027168 and PMID:16027169MGIPMID:16027168 and PMID:16027169
Tsc2Naked Mole-Ratcell population proliferation acts_upstream_ofISOMGI:19263459068941 PMID:10096549MGIPMID:10096549
Tsc2Naked Mole-Ratcell population proliferation acts_upstream_ofISOMGI:18579389068941 PMID:10491404MGIPMID:10491404
Tsc2Naked Mole-Ratcell projection organization acts_upstream_of_or_withinISOUniProtKB:P423469068941PMID:16286931MGIPMID:16286931 and REF_RGD_ID:8554187
Tsc2Naked Mole-Ratcell projection organization acts_upstream_of_or_withinISOTsc2 (Rattus norvegicus)9068941PMID:16286931MGIPMID:16286931 and REF_RGD_ID:8554187
Tsc2Naked Mole-Ratcellular response to insulin stimulus acts_upstream_of_or_withinISOTsc2 (Mus musculus)9068941 PMID:18511518MGIPMID:18511518
Tsc2Naked Mole-Ratcellular response to starvation involved_inISOTsc2 (Mus musculus)9068941 PMID:24529379UniProtPMID:24529379
Tsc2Naked Mole-Ratcellular response to starvation involved_inISOTSC2 (Homo sapiens)9068941 PMID:24529379UniProtPMID:24529379
Tsc2Naked Mole-RatD-glucose import acts_upstream_of_or_withinISOTsc2 (Mus musculus)9068941 PMID:18511518MGIPMID:18511518
Tsc2Naked Mole-Ratestablishment of cell polarity  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:20530489 and REF_RGD_ID:11568685
Tsc2Naked Mole-Ratexcitatory chemical synaptic transmission involved_inISOMGI:18579389068941 PMID:30679017MGIPMID:30679017
Tsc2Naked Mole-Ratheart development acts_upstream_of_or_withinISOMGI:19263459068941 PMID:10096549MGIPMID:10096549
Tsc2Naked Mole-Ratinhibitory chemical synaptic transmission involved_inISOMGI:18579389068941 PMID:30679017MGIPMID:30679017
Tsc2Naked Mole-Ratnegative regulation of axonogenesis  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:18794346 and REF_RGD_ID:11568688
Tsc2Naked Mole-Ratnegative regulation of B cell proliferation acts_upstream_of_or_withinISOMGI:1095839068941 PMID:16027169MGIPMID:16027169
Tsc2Naked Mole-Ratnegative regulation of cell population proliferation acts_upstream_of_or_withinISOMGI:19263459068941 PMID:10096549MGIPMID:10096549
Tsc2Naked Mole-Ratnegative regulation of cell population proliferation acts_upstream_of_or_withinISOTsc2 (Mus musculus)9068941 PMID:10827137MGIPMID:10827137
1 to 20 of 73 rows

Cellular Component
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-Ratcaveola  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:15093748 and REF_RGD_ID:1580491
Tsc2Naked Mole-Ratcell projection  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:17376623 and REF_RGD_ID:11568689
Tsc2Naked Mole-Ratcytoplasm located_inIEAPANTHER:PTN000006951150520179 TreeGrafterGO_REF:0000118
Tsc2Naked Mole-Ratcytosol located_inISOTSC2 (Homo sapiens)9068941 PMID:10585443 and PMID:24529379HPAGO_REF:0000052 more ...
Tsc2Naked Mole-Ratdendrite  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:15525761 and REF_RGD_ID:2307416
Tsc2Naked Mole-Ratglutamatergic synapse is_active_inISOTsc2 (Rattus norvegicus)9068941PMID:24889507SynGOPMID:24889507 and REF_RGD_ID:13702223
Tsc2Naked Mole-RatGolgi apparatus NOT|located_inISOTSC2 (Homo sapiens)9068941 PMID:10585443UniProtPMID:10585443
Tsc2Naked Mole-RatGolgi apparatus located_inISOTSC2 (Homo sapiens)9068941 PMID:8806680UniProtPMID:8806680
Tsc2Naked Mole-Ratgrowth cone  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:14559897 and REF_RGD_ID:1304444
Tsc2Naked Mole-Ratlysosomal membrane is_active_inISOTsc2 (Mus musculus)9068941 PMID:24529379UniProtPMID:24529379
Tsc2Naked Mole-Ratlysosomal membrane is_active_inISOTSC2 (Homo sapiens)9068941 PMID:24529379UniProtPMID:24529379
Tsc2Naked Mole-Ratlysosome located_inISOTSC2 (Homo sapiens)9068941 PMID:25936802UniProtPMID:25936802
Tsc2Naked Mole-Ratmembrane located_inISOTSC2 (Homo sapiens)9068941 PMID:16636147UniProtPMID:16636147
Tsc2Naked Mole-Ratneuronal cell body  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:15525761 and REF_RGD_ID:2307416
Tsc2Naked Mole-Ratnucleus NOT|located_inISOTSC2 (Homo sapiens)9068941 PMID:16636147UniProtPMID:16636147
Tsc2Naked Mole-Ratnucleus located_inIEAInterPro:IPR027107150520179 InterProGO_REF:0000002
Tsc2Naked Mole-Ratperinuclear region of cytoplasm located_inISOTSC2 (Homo sapiens)9068941 PMID:8806680UniProtPMID:8806680
Tsc2Naked Mole-Ratperinuclear region of cytoplasm  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:14559897 and REF_RGD_ID:1304444
Tsc2Naked Mole-Ratpostsynaptic density is_active_inISOTSC2 (Homo sapiens)9068941 PMID:27898073SynGOPMID:27898073
Tsc2Naked Mole-Ratsynapse is_active_inISOTsc2 (Mus musculus)9068941 PMID:16452087 and PMID:25211037SynGOPMID:16452087 and PMID:25211037
1 to 20 of 22 rows

Molecular Function
1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-Rat14-3-3 protein binding enablesISOTsc2 (Mus musculus)9068941 PMID:18198340MGIPMID:18198340
Tsc2Naked Mole-RatGTPase activator activity  ISOTsc2 (Rattus norvegicus)9068941 RGDPMID:12869586 and REF_RGD_ID:1580520
Tsc2Naked Mole-RatGTPase activator activity enablesIEAUniProtKB-KW:KW-0343150520179 UniProtGO_REF:0000043
Tsc2Naked Mole-RatGTPase activator activity enablesIEAUniRule:UR000415210150520179 UniProtGO_REF:0000104
Tsc2Naked Mole-RatGTPase activator activity enablesIEAInterPro:IPR000331 more ...150520179 InterProGO_REF:0000002
Tsc2Naked Mole-RatGTPase activator activity enablesIEAPANTHER:PTN000006951150520179 TreeGrafterGO_REF:0000118
Tsc2Naked Mole-RatHsp90 protein binding enablesISOUniProtKB:P07900 and UniProtKB:Q925749068941 PMID:29127155UniProtPMID:29127155
Tsc2Naked Mole-Ratphosphatase binding enablesISOTSC2 (Homo sapiens)9068941 PMID:19389623UniProtPMID:19389623
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:O001419068941 PMID:27451907IntActPMID:27451907
Tsc2Naked Mole-Ratprotein binding enablesISOPR:Q9EP539068941 PMID:11741832MGIPMID:11741832
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:P580439068941 PMID:18692468UniProtPMID:18692468
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:Q925749068941 PMID:10585443 more ...IntActPMID:10585443 more ...
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:O94763 and UniProtKB:Q9H6T39068941 PMID:28561026UniProtPMID:28561026
Tsc2Naked Mole-Ratprotein binding  ISORABEP1 (Homo sapiens)9068941 RGDPMID:9045618 and REF_RGD_ID:11568652
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:P619819068941 PMID:12364343 and PMID:33473107UniProtPMID:12364343 and PMID:33473107
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:P319469068941 PMID:12582162 more ...IntActPMID:12582162 more ...
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:P31946 and UniProtKB:P631049068941 PMID:35271311 and PMID:36931259IntActPMID:35271311 and PMID:36931259
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:P580049068941 PMID:18692468UniProtPMID:18692468
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:Q9EP539068941 PMID:20412061 and PMID:28671696IntActPMID:20412061 and PMID:28671696
Tsc2Naked Mole-Ratprotein binding enablesISOUniProtKB:Q969U69068941 PMID:18381890UniProtPMID:18381890
1 to 20 of 28 rows

RGD Manual Annotations


  

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tsc2Naked Mole-RatmTOR signaling pathway   ISOTSC2 (Homo sapiens)9068941 PIDPID:200096
PMID:22301074   PMID:30032202  



Tsc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913166,931 - 202,953 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TSC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,047,985 - 2,089,491 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,047,967 - 2,089,491 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,097,986 - 2,139,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,037,991 - 2,078,714 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,038,599 - 2,078,713NCBI
Celera162,310,097 - 2,350,826 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,022,255 - 2,063,441 (+)NCBIHuRef
CHM1_1162,097,965 - 2,138,628 (+)NCBICHM1_1
T2T-CHM13v2.0162,067,794 - 2,109,598 (+)NCBIT2T-CHM13v2.0
Tsc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,814,788 - 24,851,607 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,814,790 - 24,851,604 (-)EnsemblGRCm39 Ensembl
GRCm381724,595,816 - 24,632,676 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,595,816 - 24,632,630 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,732,882 - 24,769,574 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,323,537 - 24,360,229 (-)NCBIMGSCv36mm8
Celera1725,113,932 - 25,155,030 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.41NCBI
Tsc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,125,679 - 14,160,317 (-)NCBIGRCr8
mRatBN7.21013,621,135 - 13,655,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,621,136 - 13,655,951 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,367,921 - 18,402,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,856,767 - 17,891,310 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,355,965 - 13,390,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,962,006 - 13,996,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,961,947 - 13,996,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,778,990 - 13,813,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,848,210 - 13,883,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,848,241 - 13,882,689NCBI
Celera1013,301,129 - 13,335,713 (-)NCBICelera
Cytogenetic Map10q12NCBI
Tsc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,178,487 - 15,216,362 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,178,356 - 15,216,978 (-)NCBIChiLan1.0ChiLan1.0
TSC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,258,660 - 2,298,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,040,481 - 6,080,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016615,776 - 655,411 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,135,696 - 2,175,569 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,135,696 - 2,175,569 (+)Ensemblpanpan1.1panPan2
TSC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,865,509 - 38,898,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,865,507 - 38,898,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,104,412 - 40,137,701 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,173,764 - 39,207,052 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,173,766 - 39,207,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,858,570 - 38,891,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,830,888 - 38,864,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,309,683 - 39,342,799 (-)NCBIUU_Cfam_GSD_1.0
Tsc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,716,067 - 104,751,311 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,958,154 - 1,993,363 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,958,152 - 1,993,373 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,898,925 - 39,937,371 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,898,924 - 39,935,579 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,245,971 - 42,282,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,946,534 - 1,985,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,946,927 - 1,987,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,078,990 - 29,119,738 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000003211   ⟹   ENSHGLP00000003156
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624913166,931 - 202,953 (-)Ensembl
RefSeq Acc Id: XM_004873644   ⟹   XP_004873701
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_004873648   ⟹   XP_004873705
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_004873649   ⟹   XP_004873706
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_004873650   ⟹   XP_004873707
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_004873651   ⟹   XP_004873708
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_004873652   ⟹   XP_004873709
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_004873654   ⟹   XP_004873711
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 202,982 (-)NCBI
RefSeq Acc Id: XM_013068861   ⟹   XP_012924315
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_013068863   ⟹   XP_012924317
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_021251309   ⟹   XP_021106968
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 202,877 (-)NCBI
RefSeq Acc Id: XM_021251310   ⟹   XP_021106969
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 203,008 (-)NCBI
RefSeq Acc Id: XM_021251311   ⟹   XP_021106970
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624913166,931 - 200,390 (-)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: XP_012924317   ⟸   XM_013068863
- Peptide Label: isoform X10
- UniProtKB: A0AAX6QNU0 (UniProtKB/TrEMBL),   G5BY47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004873708   ⟸   XM_004873651
- Peptide Label: isoform X6
- UniProtKB: A0AAX6QEN3 (UniProtKB/TrEMBL),   G5BY47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004873709   ⟸   XM_004873652
- Peptide Label: isoform X9
- UniProtKB: A0AAX6QEW1 (UniProtKB/TrEMBL),   G5BY47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004873707   ⟸   XM_004873650
- Peptide Label: isoform X5
- UniProtKB: A0AAX6QHG6 (UniProtKB/TrEMBL),   G5BY47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004873701   ⟸   XM_004873644
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QDW1 (UniProtKB/TrEMBL),   G5BY47 (UniProtKB/TrEMBL)



1 to 34 of 34 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000002350 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003211 ENTREZGENE
Gene3D-CATH Leucine-rich Repeat Variant UniProtKB/TrEMBL
  Rap/Ran-GAP UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Rap/Ran-GAP_sf UniProtKB/TrEMBL
  Rap/Ran_GAP_dom UniProtKB/TrEMBL
  Tuberin UniProtKB/TrEMBL
  Tuberin-type_domain UniProtKB/TrEMBL
  Tuberin/Ral-act_asu UniProtKB/TrEMBL
  Tuberin_N UniProtKB/TrEMBL
NCBI Gene Tsc2 ENTREZGENE
PANTHER TUBERIN UniProtKB/TrEMBL
  TUBERIN UniProtKB/TrEMBL
Pfam DUF3384 UniProtKB/TrEMBL
  Rap_GAP UniProtKB/TrEMBL
  Tuberin UniProtKB/TrEMBL
PRINTS TUBERIN UniProtKB/TrEMBL
PROSITE RAPGAP UniProtKB/TrEMBL
Superfamily-SCOP ARM repeat UniProtKB/TrEMBL
  Rap/Ran-GAP UniProtKB/TrEMBL
UniProt A0AAX6QDL4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QDW1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QEN3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QEW1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QFJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QHG6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QI33 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QNU0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QRB3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SDU9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SEX8 ENTREZGENE, UniProtKB/TrEMBL
  G5BY47 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows