Bmp2 (bone morphogenetic protein 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Bmp2 (bone morphogenetic protein 2) Mus musculus
Analyze
Symbol: Bmp2
Name: bone morphogenetic protein 2
RGD ID: 735602
MGI Page MGI
Description: Enables cytokine activity and protein serine/threonine kinase activator activity. Involved in several processes, including BMP signaling pathway; heart development; and mesenchymal cell proliferation involved in ureteric bud development. Acts upstream of or within several processes, including forebrain development; heart development; and positive regulation of cell differentiation. Located in extracellular space. Is active in extracellular region and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and limb. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI467020; Bmp; BMP-2; BMP-2A; Bmp2a; bone morphogenetic protein 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392133,394,079 - 133,404,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)EnsemblGRCm39 Ensembl
GRCm382133,552,159 - 133,562,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv372133,378,935 - 133,388,621 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362133,244,640 - 133,254,326 (+)NCBIMGSCv36mm8
Celera2134,774,971 - 134,784,597 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map265.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-adrenaline  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (EXP)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
angiotensin II  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
aucubin  (ISO)
azadirachtin A  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calciol  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerivastatin  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
Didecyldimethylammonium  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
farnesyl diphosphate  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
ginsenoside Rb1  (ISO)
glucose  (ISO)
glycerol 2-phosphate  (EXP,ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (ISO)
hesperidin  (ISO)
icariin  (EXP,ISO)
imperatorin  (EXP)
isoprenaline  (ISO)
kaempferol  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP,ISO)
letrozole  (EXP)
lipopolysaccharide  (ISO)
loliolide  (ISO)
losartan  (ISO)
LY294002  (EXP)
maneb  (EXP)
menaquinone  (ISO)
menaquinone-4  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
mitomycin C  (EXP)
Morroniside  (EXP,ISO)
Muraglitazar  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naringin  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
octreotide  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pasireotide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tadalafil  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
tripotassium phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IDA)
animal organ morphogenesis  (IMP)
aortic valve development  (IMP)
astrocyte differentiation  (IDA,IGI)
atrioventricular canal morphogenesis  (IMP)
atrioventricular valve morphogenesis  (IMP)
BMP signaling pathway  (IBA,IDA,IGI,IMP,ISO)
bone development  (IMP)
bone mineralization  (IDA,IGI)
branching involved in ureteric bud morphogenesis  (IGI)
cardiac atrium formation  (IMP)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac jelly development  (IMP)
cardiac muscle cell differentiation  (IGI,ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue morphogenesis  (IMP)
cardiocyte differentiation  (ISO)
cartilage development  (IEA)
cell differentiation  (IEA)
cell fate commitment  (IMP)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IDA)
chondrocyte differentiation  (ISO)
corticotropin hormone secreting cell differentiation  (IDA)
embryonic heart tube anterior/posterior pattern specification  (IMP)
endocardial cushion formation  (IMP)
endocardial cushion morphogenesis  (IMP)
endodermal-mesodermal cell signaling  (ISO)
epithelial to mesenchymal transition  (IMP,ISO)
gene expression  (IDA)
heart development  (IMP,ISO)
heart induction  (ISO)
in utero embryonic development  (IMP)
inflammatory response  (IEP)
inner ear development  (IDA)
lung vasculature development  (ISO)
mesenchymal cell differentiation  (ISO)
mesenchymal cell proliferation involved in ureteric bud development  (IMP)
mesenchyme development  (ISO)
negative regulation of aldosterone biosynthetic process  (ISO)
negative regulation of calcium-independent cell-cell adhesion  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (IGI,ISO)
negative regulation of cortisol biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (IDA,ISO)
negative regulation of insulin-like growth factor receptor signaling pathway  (ISO)
negative regulation of muscle cell differentiation  (IDA)
negative regulation of smooth muscle cell proliferation  (IGI,ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
Notch signaling pathway  (IMP)
odontogenesis of dentin-containing tooth  (IDA)
ossification  (IEA)
osteoblast differentiation  (IDA,IGI,ISO)
osteoclast differentiation  (ISO)
ovulation cycle  (ISO)
pericardium development  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of astrocyte differentiation  (IDA,IGI)
positive regulation of bone mineralization  (IDA,ISO)
positive regulation of bone mineralization involved in bone maturation  (ISO)
positive regulation of cartilage development  (IDA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell differentiation  (IDA)
positive regulation of epithelial to mesenchymal transition  (IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extracellular matrix constituent secretion  (IMP)
positive regulation of fat cell differentiation  (IDA)
positive regulation of gene expression  (IDA,IMP,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (IGI)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron differentiation  (IDA)
positive regulation of odontoblast differentiation  (IMP)
positive regulation of odontogenesis  (IDA)
positive regulation of ossification  (IDA,ISO)
positive regulation of osteoblast differentiation  (IDA,IMP)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of Wnt signaling pathway  (IDA)
protein destabilization  (IDA,IGI)
proteoglycan metabolic process  (IGI)
regulation of DNA-templated transcription  (ISO)
regulation of odontogenesis of dentin-containing tooth  (IGI)
response to bacterium  (IEP)
response to hypoxia  (IMP)
response to mechanical stimulus  (ISO)
response to retinoic acid  (ISO)
telencephalon development  (ISO)
telencephalon regionalization  (IGI)
thyroid-stimulating hormone-secreting cell differentiation  (IDA)
transcription by RNA polymerase II  (IDA,IMP)
transforming growth factor beta receptor signaling pathway  (TAS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal appendicular skeleton morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardiac jelly morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal forelimb stylopod morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal head shape  (IAGP)
abnormal heart development  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal hindlimb stylopod morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal interdigital cell death  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mandibular angle morphology  (IAGP)
abnormal mandibular condyloid process morphology  (IAGP)
abnormal maxillary shelf morphology  (IAGP)
abnormal maxillary zygomatic process morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal proamniotic cavity morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal temporal bone zygomatic process morphology  (IAGP)
abnormal tongue position  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vertebral column morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent atrioventricular cushions  (IAGP)
absent deltoid tuberosity  (IAGP)
absent mandibular angle  (IAGP)
absent mandibular condyloid process  (IAGP)
absent mandibular coronoid process  (IAGP)
absent maxilla  (IAGP)
absent temporal bone squamous part  (IAGP)
absent tympanic ring  (IAGP)
absent zygomatic bone  (IAGP)
broad limb buds  (IAGP)
cardiac edema  (IAGP)
cleft palate  (IAGP)
complete cleft palate  (IAGP)
decreased autopod size  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased bone volume  (IAGP)
decreased embryo size  (IAGP)
decreased litter size  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased rib number  (IAGP)
decreased survivor rate  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased tympanic ring size  (IAGP)
delayed allantois development  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed heart development  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
exencephaly  (IAGP)
failure of palatal shelf elevation  (IAGP)
fragile skeleton  (IAGP)
fused joints  (IAGP)
herniated abdominal wall  (IAGP)
impaired osteoblast differentiation  (IAGP)
incomplete embryo turning  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
kinked tail  (IAGP)
large anterior fontanelle  (IAGP)
long gestation period  (IAGP)
mandible hypoplasia  (IAGP)
maxilla hypoplasia  (IAGP)
micrognathia  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pericardial edema  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polydactyly  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
short humerus  (IAGP)
short mandible  (IAGP)
small alisphenoid bone  (IAGP)
small interparietal bone  (IAGP)
small mandible  (IAGP)
small Meckel's cartilage  (IAGP)
small nasal bone  (IAGP)
small temporal bone squamous part  (IAGP)
small vertebrae  (IAGP)
small zygomatic bone  (IAGP)
syndactyly  (IAGP)
vertebral fusion  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Doak SH, etal., Cancer Genet Cytogenet. 2007 Jul 15;176(2):161-5.
3. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
4. Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein. Iimura T, etal., Biochem Biophys Res Commun 1994 Jun 15;201(2):980-7.
5. Zhonghua nan ke xue = National journal of andrology Li ZL, etal., Zhonghua Nan Ke Xue. 2006 Feb;12(2):126-8, 132.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia. Mu Y, etal., Genet Mol Res. 2012 Nov 28;11(4):4110-20. doi: 10.4238/2012.September.25.5.
10. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Sandner B, etal., Stem Cell Res. 2013 Sep;11(2):758-71. doi: 10.1016/j.scr.2013.05.003. Epub 2013 May 16.
18. Association of bone morphogenetic proteins with otosclerosis. Schrauwen I, etal., J Bone Miner Res. 2008 Apr;23(4):507-16.
19. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
20. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
21. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
22. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
Additional References at PubMed
PMID:1354647   PMID:1460021   PMID:1468569   PMID:1613559   PMID:1916246   PMID:1970330   PMID:2226202   PMID:2347591   PMID:2481605   PMID:3201241   PMID:7577436   PMID:7589793  
PMID:7605753   PMID:7657163   PMID:7798324   PMID:7799920   PMID:7811286   PMID:7848824   PMID:7902327   PMID:7916325   PMID:8018727   PMID:8104708   PMID:8111131   PMID:8118101  
PMID:8177505   PMID:8536632   PMID:8616889   PMID:8617512   PMID:8651889   PMID:8674409   PMID:8684466   PMID:8698813   PMID:8769660   PMID:8787747   PMID:8792608   PMID:8808404  
PMID:8854867   PMID:8896987   PMID:8898212   PMID:8898217   PMID:9003457   PMID:9056639   PMID:9152009   PMID:9152011   PMID:9187146   PMID:9189614   PMID:9203584   PMID:9213002  
PMID:9244299   PMID:9268344   PMID:9303341   PMID:9362463   PMID:9415424   PMID:9425131   PMID:9463347   PMID:9477322   PMID:9501024   PMID:9531541   PMID:9585504   PMID:9620855  
PMID:9664685   PMID:9664686   PMID:9671585   PMID:9733575   PMID:9768360   PMID:9769173   PMID:9786991   PMID:9799237   PMID:9799429   PMID:9811582   PMID:9847236   PMID:9853822  
PMID:9876182   PMID:9880512   PMID:9892669   PMID:10075839   PMID:10086355   PMID:10098408   PMID:10204532   PMID:10204534   PMID:10205054   PMID:10330496   PMID:10331973   PMID:10349636  
PMID:10391928   PMID:10398531   PMID:10415326   PMID:10462412   PMID:10471509   PMID:10486560   PMID:10499586   PMID:10515202   PMID:10534616   PMID:10625551   PMID:10642790   PMID:10662638  
PMID:10662648   PMID:10684250   PMID:10693795   PMID:10704389   PMID:10716617   PMID:10769235   PMID:10804187   PMID:10835630   PMID:10903171   PMID:10922068   PMID:10926756   PMID:11042159  
PMID:11044393   PMID:11076761   PMID:11076861   PMID:11084657   PMID:11087629   PMID:11091071   PMID:11101845   PMID:11101846   PMID:11152636   PMID:11160153   PMID:11203701   PMID:11217851  
PMID:11371349   PMID:11389830   PMID:11400162   PMID:11401393   PMID:11401407   PMID:11476582   PMID:11512673   PMID:11518254   PMID:11572777   PMID:11641221   PMID:11698278   PMID:11719201  
PMID:11731698   PMID:11788714   PMID:11792561   PMID:11850178   PMID:11854453   PMID:11955708   PMID:12010793   PMID:12015971   PMID:12023967   PMID:12074550   PMID:12075933   PMID:12084724  
PMID:12117807   PMID:12141440   PMID:12151307   PMID:12152071   PMID:12162497   PMID:12162498   PMID:12163415   PMID:12194849   PMID:12198547   PMID:12220517   PMID:12239209   PMID:12354394  
PMID:12361961   PMID:12385000   PMID:12397106   PMID:12399319   PMID:12403705   PMID:12414734   PMID:12421925   PMID:12461181   PMID:12464426   PMID:12466851   PMID:12469905   PMID:12469906  
PMID:12477932   PMID:12511606   PMID:12514121   PMID:12569130   PMID:12589053   PMID:12647290   PMID:12663654   PMID:12666204   PMID:12674331   PMID:12701101   PMID:12702154   PMID:12704803  
PMID:12708796   PMID:12759356   PMID:12804760   PMID:12805214   PMID:12815054   PMID:12854828   PMID:12897139   PMID:12923052   PMID:12957859   PMID:12960086   PMID:12960089   PMID:14512019  
PMID:14522949   PMID:14567981   PMID:14573624   PMID:14584895   PMID:14602679   PMID:14606520   PMID:14623234   PMID:14627707   PMID:14633986   PMID:14660436   PMID:14667410   PMID:14688221  
PMID:14688393   PMID:14699493   PMID:14699574   PMID:14701881   PMID:14723846   PMID:14757762   PMID:15039429   PMID:15042700   PMID:15064755   PMID:15071597   PMID:15075292   PMID:15110716  
PMID:15136142   PMID:15150273   PMID:15161906   PMID:15162500   PMID:15162503   PMID:15170224   PMID:15175325   PMID:15178686   PMID:15188429   PMID:15197161   PMID:15201225   PMID:15226263  
PMID:15254224   PMID:15289457   PMID:15305290   PMID:15315763   PMID:15322112   PMID:15342482   PMID:15342483   PMID:15358784   PMID:15383550   PMID:15476453   PMID:15525533   PMID:15526281  
PMID:15533830   PMID:15565649   PMID:15573378   PMID:15657444   PMID:15716346   PMID:15765505   PMID:15767668   PMID:15820682   PMID:15837799   PMID:15843407   PMID:15843414   PMID:15882580  
PMID:15901664   PMID:15919755   PMID:15925496   PMID:15930102   PMID:15944188   PMID:15963767   PMID:15975920   PMID:15978571   PMID:15986484   PMID:16054035   PMID:16099986   PMID:16109715  
PMID:16112648   PMID:16120640   PMID:16127465   PMID:16141072   PMID:16141073   PMID:16150699   PMID:16151852   PMID:16207730   PMID:16210626   PMID:16234975   PMID:16308330   PMID:16314491  
PMID:16368545   PMID:16412416   PMID:16423343   PMID:16495310   PMID:16497730   PMID:16503488   PMID:16522160   PMID:16540514   PMID:16554359   PMID:16602821   PMID:16604073   PMID:16613856  
PMID:16618938   PMID:16621789   PMID:16647687   PMID:16716259   PMID:16728477   PMID:16730346   PMID:16734382   PMID:16754660   PMID:16783635   PMID:16791844   PMID:16809539   PMID:16828469  
PMID:16835229   PMID:16839541   PMID:16839542   PMID:16880529   PMID:16887830   PMID:16916379   PMID:16927309   PMID:16935278   PMID:16952347   PMID:17018525   PMID:17020882   PMID:17021042  
PMID:17023412   PMID:17035289   PMID:17060321   PMID:17066377   PMID:17085452   PMID:17099713   PMID:17120779   PMID:17126317   PMID:17160517   PMID:17194222   PMID:17196193   PMID:17199044  
PMID:17218603   PMID:17226753   PMID:17238175   PMID:17259303   PMID:17283059   PMID:17303760   PMID:17317039   PMID:17350578   PMID:17352693   PMID:17359964   PMID:17360773   PMID:17397822  
PMID:17439946   PMID:17452461   PMID:17460765   PMID:17472960   PMID:17473173   PMID:17500060   PMID:17515606   PMID:17522049   PMID:17522060   PMID:17537800   PMID:17553463   PMID:17585069  
PMID:17601530   PMID:17662325   PMID:17676634   PMID:17682830   PMID:17693062   PMID:17693602   PMID:17698011   PMID:17711857   PMID:17784959   PMID:17848526   PMID:17878071   PMID:17900554  
PMID:17911046   PMID:17913788   PMID:17922907   PMID:17936260   PMID:17951031   PMID:17951258   PMID:17955502   PMID:17967138   PMID:17971207   PMID:18000065   PMID:18003744   PMID:18043734  
PMID:18050218   PMID:18056716   PMID:18096605   PMID:18155190   PMID:18159948   PMID:18202659   PMID:18250097   PMID:18250098   PMID:18256193   PMID:18287057   PMID:18287559   PMID:18292603  
PMID:18329379   PMID:18331343   PMID:18380899   PMID:18382765   PMID:18391523   PMID:18393307   PMID:18404215   PMID:18407830   PMID:18424784   PMID:18446812   PMID:18449905   PMID:18483623  
PMID:18506848   PMID:18515207   PMID:18572160   PMID:18586671   PMID:18617533   PMID:18617694   PMID:18628975   PMID:18667074   PMID:18676816   PMID:18697220   PMID:18703506   PMID:18703512  
PMID:18769073   PMID:18775421   PMID:18784367   PMID:18832392   PMID:18927151   PMID:18927154   PMID:18948417   PMID:18981480   PMID:19000668   PMID:19013147   PMID:19021035   PMID:19023895  
PMID:19038999   PMID:19084512   PMID:19097048   PMID:19103169   PMID:19103752   PMID:19116164   PMID:19139264   PMID:19141668   PMID:19153222   PMID:19164599   PMID:19170762   PMID:19208758  
PMID:19210962   PMID:19211807   PMID:19213727   PMID:19229034   PMID:19251704   PMID:19252486   PMID:19272526   PMID:19299468   PMID:19304890   PMID:19327734   PMID:19341725   PMID:19383632  
PMID:19391114   PMID:19393343   PMID:19393622   PMID:19397592   PMID:19398045   PMID:19401440   PMID:19439426   PMID:19442313   PMID:19483677   PMID:19501082   PMID:19521566   PMID:19556507  
PMID:19617624   PMID:19646521   PMID:19650108   PMID:19661464   PMID:19668217   PMID:19672814   PMID:19703439   PMID:19717565   PMID:19737815   PMID:19744575   PMID:19760469   PMID:19766620  
PMID:19769959   PMID:19780203   PMID:19782107   PMID:19783740   PMID:19795382   PMID:19804412   PMID:19819979   PMID:19842177   PMID:19846762   PMID:19852960   PMID:19892583   PMID:19922873  
PMID:19934377   PMID:19943263   PMID:19995912   PMID:20007850   PMID:20016822   PMID:20034106   PMID:20034107   PMID:20039313   PMID:20042692   PMID:20043884   PMID:20060812   PMID:20063299  
PMID:20065295   PMID:20109072   PMID:20123092   PMID:20129696   PMID:20130285   PMID:20154408   PMID:20159597   PMID:20162696   PMID:20359476   PMID:20376342   PMID:20398647   PMID:20404326  
PMID:20410205   PMID:20412016   PMID:20432245   PMID:20443832   PMID:20466812   PMID:20484413   PMID:20493948   PMID:20508035   PMID:20551513   PMID:20638987   PMID:20643351   PMID:20651281  
PMID:20652605   PMID:20654612   PMID:20665818   PMID:20675382   PMID:20684029   PMID:20685737   PMID:20691664   PMID:20701465   PMID:20727875   PMID:20803506   PMID:20807599   PMID:20847738  
PMID:20861306   PMID:20883686   PMID:20890042   PMID:20929948   PMID:20941510   PMID:20944546   PMID:20960561   PMID:20969841   PMID:21029048   PMID:21055905   PMID:21056707   PMID:21072209  
PMID:21084449   PMID:21087601   PMID:21123517   PMID:21135100   PMID:21135503   PMID:21145505   PMID:21185278   PMID:21187450   PMID:21192082   PMID:21194678   PMID:21267068   PMID:21268088  
PMID:21271257   PMID:21300867   PMID:21304516   PMID:21306641   PMID:21307096   PMID:21311046   PMID:21324897   PMID:21328453   PMID:21350216   PMID:21364421   PMID:21386911   PMID:21436263  
PMID:21445260   PMID:21465616   PMID:21466799   PMID:21471203   PMID:21503889   PMID:21504044   PMID:21557453   PMID:21571370   PMID:21597012   PMID:21597270   PMID:21624478   PMID:21654186  
PMID:21677750   PMID:21688123   PMID:21695256   PMID:21725307   PMID:21731673   PMID:21736745   PMID:21749862   PMID:21757651   PMID:21779394   PMID:21795542   PMID:21821669   PMID:21829553  
PMID:21839733   PMID:21859498   PMID:21873635   PMID:21888945   PMID:21905163   PMID:21911092   PMID:21938723   PMID:21976273   PMID:21981321   PMID:21983003   PMID:21984813   PMID:22009883  
PMID:22072987   PMID:22075149   PMID:22076636   PMID:22100262   PMID:22102412   PMID:22114682   PMID:22130515   PMID:22150562   PMID:22170575   PMID:22213482   PMID:22219353   PMID:22237159  
PMID:22240098   PMID:22275066   PMID:22283839   PMID:22297545   PMID:22370001   PMID:22382872   PMID:22387309   PMID:22432025   PMID:22461901   PMID:22465667   PMID:22485132   PMID:22493443  
PMID:22496664   PMID:22547067   PMID:22560297   PMID:22583106   PMID:22587915   PMID:22644325   PMID:22647617   PMID:22662233   PMID:22682244   PMID:22689267   PMID:22696396   PMID:22701694  
PMID:22705977   PMID:22711842   PMID:22718343   PMID:22779446   PMID:22819676   PMID:22829700   PMID:22846673   PMID:22847922   PMID:22855527   PMID:22885182   PMID:22911573   PMID:22972661  
PMID:22984607   PMID:22995554   PMID:23012479   PMID:23017661   PMID:23028704   PMID:23032104   PMID:23034633   PMID:23038774   PMID:23095882   PMID:23103586   PMID:23107765   PMID:23190887  
PMID:23200275   PMID:23219944   PMID:23266329   PMID:23311625   PMID:23341458   PMID:23341776   PMID:23344708   PMID:23349763   PMID:23351706   PMID:23360989   PMID:23362348   PMID:23382810  
PMID:23396188   PMID:23416071   PMID:23423383   PMID:23429583   PMID:23451037   PMID:23460641   PMID:23497137   PMID:23560048   PMID:23560082   PMID:23584254   PMID:23593489   PMID:23610558  
PMID:23706163   PMID:23712751   PMID:23746860   PMID:23751042   PMID:23754280   PMID:23807640   PMID:23821550   PMID:23824573   PMID:23825702   PMID:23843349   PMID:23843612   PMID:23863481  
PMID:23891934   PMID:23892366   PMID:23896528   PMID:23916851   PMID:23924071   PMID:23948603   PMID:23951127   PMID:23963447   PMID:24006258   PMID:24018651   PMID:24024213   PMID:24025680  
PMID:24068957   PMID:24141051   PMID:24235143   PMID:24240189   PMID:24278323   PMID:24362451   PMID:24369527   PMID:24415953   PMID:24417671   PMID:24424065   PMID:24448347   PMID:24460720  
PMID:24491691   PMID:24505141   PMID:24551211   PMID:24583261   PMID:24618599   PMID:24633704   PMID:24647893   PMID:24648278   PMID:24680892   PMID:24726283   PMID:24831012   PMID:24837969  
PMID:24853417   PMID:24867947   PMID:24899573   PMID:24909139   PMID:24971735   PMID:25029242   PMID:25041854   PMID:25043193   PMID:25043591   PMID:25053429   PMID:25082703   PMID:25100727  
PMID:25107907   PMID:25138700   PMID:25186749   PMID:25191703   PMID:25232676   PMID:25249463   PMID:25300579   PMID:25318679   PMID:25329657   PMID:25331953   PMID:25336743   PMID:25382630  
PMID:25428889   PMID:25470749   PMID:25488669   PMID:25491151   PMID:25536014   PMID:25545831   PMID:25546423   PMID:25592835   PMID:25599332   PMID:25603465   PMID:25605784   PMID:25615642  
PMID:25617432   PMID:25670795   PMID:25677945   PMID:25736226   PMID:25746793   PMID:25759071   PMID:25781922   PMID:25810521   PMID:25864564   PMID:25967044   PMID:26037045   PMID:26062940  
PMID:26113728   PMID:26141517   PMID:26212702   PMID:26214286   PMID:26227988   PMID:26229008   PMID:26238476   PMID:26244796   PMID:26321200   PMID:26344756   PMID:26404484   PMID:26409788  
PMID:26414873   PMID:26450967   PMID:26459221   PMID:26465321   PMID:26472929   PMID:26475222   PMID:26491697   PMID:26595646   PMID:26635037   PMID:26647760   PMID:26681207   PMID:26721501  
PMID:26757978   PMID:26801561   PMID:26813283   PMID:26826495   PMID:26890302   PMID:26899202   PMID:26952977   PMID:26953352   PMID:26959361   PMID:27019229   PMID:27026076   PMID:27030100  
PMID:27056911   PMID:27060915   PMID:27066502   PMID:27068110   PMID:27113717   PMID:27146352   PMID:27146698   PMID:27155222   PMID:27188281   PMID:27217206   PMID:27225772   PMID:27250101  
PMID:27283840   PMID:27348588   PMID:27376238   PMID:27424936   PMID:27477105   PMID:27506892   PMID:27512956   PMID:27567726   PMID:27633082   PMID:27680507   PMID:27732085   PMID:27802170  
PMID:27827819   PMID:27856249   PMID:27886213   PMID:27903529   PMID:27922003   PMID:27930311   PMID:27932058   PMID:28019696   PMID:28043948   PMID:28049832   PMID:28108317   PMID:28130833  
PMID:28172500   PMID:28173811   PMID:28218627   PMID:28256809   PMID:28324176   PMID:28395271   PMID:28401685   PMID:28418030   PMID:28457943   PMID:28460577   PMID:28527696   PMID:28538179  
PMID:28619823   PMID:28711495   PMID:28790014   PMID:28794157   PMID:28815688   PMID:28819210   PMID:28844842   PMID:28846100   PMID:28874785   PMID:28883412   PMID:28900034   PMID:28924381  
PMID:29029363   PMID:29031500   PMID:29107477   PMID:29148101   PMID:29184513   PMID:29198724   PMID:29374556   PMID:29378183   PMID:29409032   PMID:29475039   PMID:29489425   PMID:29540665  
PMID:29563538   PMID:29665134   PMID:29771958   PMID:29853617   PMID:29891551   PMID:30021842   PMID:30048819   PMID:30061196   PMID:30116001   PMID:30134070   PMID:30154422   PMID:30181118  
PMID:30201295   PMID:30235284   PMID:30292786   PMID:30352686   PMID:30413887   PMID:30454898   PMID:30478858   PMID:30523637   PMID:30570432   PMID:30593824   PMID:30699351   PMID:30700748  
PMID:30735122   PMID:30745426   PMID:30770380   PMID:30842446   PMID:30853186   PMID:30854720   PMID:30936179   PMID:30944305   PMID:30950569   PMID:30963569   PMID:30980961   PMID:31038803  
PMID:31160554   PMID:31199918   PMID:31220272   PMID:31277646   PMID:31292298   PMID:31311865   PMID:31429922   PMID:31487395   PMID:31562859   PMID:31566563   PMID:31649032   PMID:31661767  
PMID:31672960   PMID:31729356   PMID:31800957   PMID:31987892   PMID:32135355   PMID:32169905   PMID:32179857   PMID:32226305   PMID:32301970   PMID:32338217   PMID:32391984   PMID:32427842  
PMID:32439755   PMID:32493750   PMID:32537777   PMID:32561790   PMID:32652747   PMID:32655758   PMID:32708917   PMID:32727092   PMID:32732898   PMID:32750747   PMID:32879393   PMID:33153107  
PMID:33171097   PMID:33248111   PMID:33297480   PMID:33302058   PMID:33307770   PMID:33326788   PMID:33483579   PMID:33537834   PMID:33547543   PMID:33561140   PMID:33580754   PMID:33590845  
PMID:33608506   PMID:33614644   PMID:33659251   PMID:33660785   PMID:33816629   PMID:33846290   PMID:33851585   PMID:33998217   PMID:34062094   PMID:34108685   PMID:34150743   PMID:34249945  
PMID:34292881   PMID:34294700   PMID:34450502   PMID:34483952   PMID:34576009   PMID:34582356   PMID:34630166   PMID:34773433   PMID:34957089   PMID:34980329   PMID:35084365   PMID:35164658  
PMID:35194044   PMID:35383354   PMID:35414789   PMID:35421216   PMID:35639639   PMID:35833708   PMID:36347256   PMID:36414704   PMID:36683552   PMID:36706916   PMID:36764291   PMID:36916392  
PMID:37000005   PMID:37017267   PMID:37120909   PMID:37154419   PMID:37159303   PMID:37175932   PMID:37245142   PMID:37290397   PMID:37360688   PMID:37385754   PMID:37407581   PMID:37607547  
PMID:37702066   PMID:37852253  


Genomics

Comparative Map Data
Bmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392133,394,079 - 133,404,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)EnsemblGRCm39 Ensembl
GRCm382133,552,159 - 133,562,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv372133,378,935 - 133,388,621 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362133,244,640 - 133,254,326 (+)NCBIMGSCv36mm8
Celera2134,774,971 - 134,784,597 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map265.21NCBI
BMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38206,767,686 - 6,780,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl206,767,686 - 6,780,246 (+)EnsemblGRCh38hg38GRCh38
GRCh37206,748,333 - 6,760,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,696,745 - 6,708,910 (+)NCBINCBI36Build 36hg18NCBI36
Build 34206,697,206 - 6,707,769NCBI
Celera206,819,903 - 6,832,070 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef206,705,637 - 6,717,811 (+)NCBIHuRef
CHM1_1206,748,804 - 6,760,970 (+)NCBICHM1_1
T2T-CHM13v2.0206,808,871 - 6,821,444 (+)NCBIT2T-CHM13v2.0
Bmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83141,264,648 - 141,275,416 (+)NCBIGRCr8
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Celera3119,596,986 - 119,605,358 (+)NCBICelera
Cytogenetic Map3q36NCBI
Bmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBIChiLan1.0ChiLan1.0
BMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2217,692,819 - 7,704,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1207,689,639 - 7,701,158 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0206,765,161 - 6,777,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1206,546,173 - 6,558,627 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl206,546,173 - 6,558,610 (+)Ensemblpanpan1.1panPan2
BMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,199,667 - 15,211,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,200,291 - 15,212,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2415,022,880 - 15,034,779 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02415,603,929 - 15,615,829 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2415,603,981 - 15,615,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,210,353 - 15,222,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,320,936 - 15,332,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02415,650,158 - 15,662,056 (-)NCBIUU_Cfam_GSD_1.0
Bmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648512,428,710 - 12,439,454 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1715,749,835 - 15,761,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11715,750,487 - 15,762,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21717,052,609 - 17,064,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1231,349,394 - 31,361,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl231,348,808 - 31,360,901 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607113,190,629 - 13,202,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247417,706,236 - 7,719,484 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247417,706,205 - 7,717,677 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmp2
338 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:226
Interacting mature miRNAs:242
Transcripts:ENSMUST00000028836
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13207586Mwmlpt2_mMorris water maze latency to platform, training, 2 (mouse)2131616184139216184Mouse
13207590Mwmlpa2_mMorris water maze latency to platform, all, 2 (mouse)2131616184139616184Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse

Markers in Region
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,365 - 133,561,540UniSTSGRCm38
MGSCv372133,386,912 - 133,387,036UniSTSGRCm37
MGSCv372133,380,171 - 133,380,419UniSTSGRCm37
MGSCv372133,386,850 - 133,387,090UniSTSGRCm37
MGSCv372133,386,239 - 133,386,522UniSTSGRCm37
MGSCv372133,386,821 - 133,387,275UniSTSGRCm37
Celera2134,783,077 - 134,783,252UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
cM Map276.1UniSTS
MARC_41388-41390:1086358658:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,260 - 133,561,728UniSTSGRCm38
MGSCv372133,386,996 - 133,387,464UniSTSGRCm37
Celera2134,782,972 - 134,783,440UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
RH131457  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,416 - 133,561,609UniSTSGRCm38
MGSCv372133,387,152 - 133,387,345UniSTSGRCm37
Celera2134,783,128 - 134,783,321UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
L25602  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,563,194 - 133,563,352UniSTSGRCm38
MGSCv372133,388,930 - 133,389,088UniSTSGRCm37
Celera2134,784,906 - 134,785,064UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
Whitehead/MRC_RH21643.93UniSTS
D2Mit279  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,560,540 - 133,560,690UniSTSGRCm38
MGSCv372133,386,276 - 133,386,426UniSTSGRCm37
Celera2134,782,252 - 134,782,402UniSTS
Cytogenetic Map2F2UniSTS
cM Map274.0UniSTS
Whitehead Genetic261.2UniSTS
AI467020  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,562,399 - 133,562,499UniSTSGRCm38
MGSCv372133,388,135 - 133,388,235UniSTSGRCm37
Celera2134,784,111 - 134,784,211UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
Whitehead/MRC_RH21644.03UniSTS
PMC156609P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,397 - 133,561,474UniSTSGRCm38
MGSCv372133,387,133 - 133,387,210UniSTSGRCm37
Celera2134,783,109 - 134,783,186UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,176 - 133,561,300UniSTSGRCm38
MGSCv372133,386,912 - 133,387,036UniSTSGRCm37
Celera2134,782,888 - 134,783,012UniSTS
Cytogenetic Map2F2UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,560,503 - 133,560,786UniSTSGRCm38
MGSCv372133,386,239 - 133,386,522UniSTSGRCm37
Celera2134,782,215 - 134,782,498UniSTS
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,085 - 133,561,539UniSTSGRCm38
MGSCv372133,386,821 - 133,387,275UniSTSGRCm37
Celera2134,782,797 - 134,783,251UniSTS
Cytogenetic Map2F2UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F2UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,561,114 - 133,561,354UniSTSGRCm38
MGSCv372133,386,850 - 133,387,090UniSTSGRCm37
Celera2134,782,826 - 134,783,066UniSTS
Cytogenetic Map2F2UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2F2UniSTS
cM Map276.1UniSTS
Bmp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382133,554,435 - 133,554,683UniSTSGRCm38
MGSCv372133,380,171 - 133,380,419UniSTSGRCm37
Celera2134,776,207 - 134,776,455UniSTS
Cytogenetic Map2F2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000028836   ⟹   ENSMUSP00000028836
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)Ensembl
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)Ensembl
RefSeq Acc Id: NM_007553   ⟹   NP_031579
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392133,394,079 - 133,404,816 (+)NCBI
GRCm382133,552,159 - 133,562,896 (+)NCBI
MGSCv372133,378,935 - 133,388,621 (+)RGD
Celera2134,773,931 - 134,784,608 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031579   ⟸   NM_007553
- Peptide Label: preproprotein
- UniProtKB: Q497W8 (UniProtKB/Swiss-Prot),   P21274 (UniProtKB/Swiss-Prot),   Q3V1I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028836   ⟸   ENSMUST00000028836
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21274-F1-model_v2 AlphaFold P21274 1-394 view protein structure

Promoters
RGD ID:6830915
Promoter ID:MM_KWN:31886
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:ENSMUST00000028836
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362133,377,851 - 133,378,351 (+)MPROMDB
RGD ID:6878876
Promoter ID:EPDNEW_M2889
Type:multiple initiation site
Name:Bmp2_1
Description:Mus musculus bone morphogenetic protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382133,552,226 - 133,552,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88177 AgrOrtholog
Ensembl Genes ENSMUSG00000027358 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028836 ENTREZGENE
  ENSMUST00000028836.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BMP2_TGF_beta-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12156 UniProtKB/Swiss-Prot
MGD MGI:88177 ENTREZGENE
NCBI Gene 12156 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmp2 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BMP2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V1I4 ENTREZGENE, UniProtKB/TrEMBL
  Q497W8 ENTREZGENE
UniProt Secondary Q497W8 UniProtKB/Swiss-Prot