Bmp2 (bone morphogenetic protein 2) - Rat Genome Database

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Gene: Bmp2 (bone morphogenetic protein 2) Ictidomys tridecemlineatus
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Symbol: Bmp2
Name: bone morphogenetic protein 2
RGD ID: 12680911
Description: ENCODES a protein that exhibits growth factor activity (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN ameloblast differentiation (ortholog); animal organ morphogenesis (ortholog); aortic valve development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH bone disease (ortholog); Bone Fractures (ortholog); brachydactyly type A2 (ortholog); FOUND IN cytoplasm (ortholog); extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
aortic valve development  (IEA,ISO)
astrocyte differentiation  (IEA,ISO)
atrioventricular canal morphogenesis  (IEA)
atrioventricular valve morphogenesis  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
BMP signaling pathway involved in heart development  (IEA)
BMP signaling pathway involved in heart induction  (IEA)
bone development  (IEA)
bone mineralization  (IEA,ISO)
bone mineralization involved in bone maturation  (ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cardiac atrium formation  (IEA)
cardiac epithelial to mesenchymal transition  (IEA)
cardiac jelly development  (IEA)
cardiac muscle cell differentiation  (IEA)
cardiac muscle tissue morphogenesis  (IEA,ISO)
cardiocyte differentiation  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (IEA,ISO)
chondrocyte differentiation  (IEA)
corticotropin hormone secreting cell differentiation  (IEA,ISO)
embryonic heart tube anterior/posterior pattern specification  (IEA,ISO)
endocardial cushion formation  (IEA)
endocardial cushion morphogenesis  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISO)
gene expression  (IEA)
heart development  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inflammatory response  (IEA)
inner ear development  (IEA,ISO)
mesenchymal cell differentiation  (IEA)
mesenchymal cell proliferation involved in ureteric bud development  (IEA)
mesenchyme development  (IEA)
negative regulation of aldosterone biosynthetic process  (IEA)
negative regulation of calcium-independent cell-cell adhesion  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cardiac muscle cell differentiation  (IEA)
negative regulation of cell cycle  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cortisol biosynthetic process  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of fat cell differentiation  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of insulin-like growth factor receptor signaling pathway  (IEA)
negative regulation of MAP kinase activity  (IEA,ISO)
negative regulation of muscle cell differentiation  (IEA)
negative regulation of smooth muscle cell proliferation  (IEA)
negative regulation of steroid biosynthetic process  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of Wnt signaling pathway involved in heart development  (IEA)
Notch signaling pathway  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
osteoclast differentiation  (IEA)
ovulation cycle  (ISO)
pathway-restricted SMAD protein phosphorylation  (IEA)
pericardium development  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of bone mineralization  (IEA)
positive regulation of bone mineralization involved in bone maturation  (IEA)
positive regulation of cartilage development  (IEA,ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell differentiation  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of extracellular matrix constituent secretion  (IEA)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of odontogenesis  (IEA,ISO)
positive regulation of ossification  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of osteoblast proliferation  (IEA)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of phosphatase activity  (IEA,ISO)
positive regulation of protein binding  (IEA)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  (IEA)
positive regulation of Wnt signaling pathway  (IEA,ISO)
positive regulation of Wnt signaling pathway by BMP signaling pathway  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein phosphorylation  (IEA)
proteoglycan metabolic process  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
response to bacterium  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to mechanical stimulus  (ISO)
response to retinoic acid  (ISO)
SMAD protein signal transduction  (IEA)
telencephalon development  (IEA,ISO)
telencephalon regionalization  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Bmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38206,767,686 - 6,780,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl206,767,686 - 6,780,246 (+)EnsemblGRCh38hg38GRCh38
GRCh37206,748,333 - 6,760,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,696,745 - 6,708,910 (+)NCBINCBI36Build 36hg18NCBI36
Build 34206,697,206 - 6,707,769NCBI
Celera206,819,903 - 6,832,070 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef206,705,637 - 6,717,811 (+)NCBIHuRef
CHM1_1206,748,804 - 6,760,970 (+)NCBICHM1_1
T2T-CHM13v2.0206,808,871 - 6,821,444 (+)NCBIT2T-CHM13v2.0
Bmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392133,394,079 - 133,404,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)EnsemblGRCm39 Ensembl
GRCm382133,552,159 - 133,562,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv372133,378,935 - 133,388,621 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362133,244,640 - 133,254,326 (+)NCBIMGSCv36mm8
Celera2134,774,971 - 134,784,597 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map265.21NCBI
Bmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIRnor_WKY
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Celera3119,596,986 - 119,605,358 (+)NCBICelera
Cytogenetic Map3q36NCBI
Bmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBIChiLan1.0ChiLan1.0
BMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1206,546,173 - 6,558,627 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl206,546,173 - 6,558,610 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0206,765,161 - 6,777,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,199,667 - 15,211,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,200,291 - 15,212,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2415,022,880 - 15,034,779 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02415,603,929 - 15,615,829 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2415,603,981 - 15,615,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,210,353 - 15,222,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,320,936 - 15,332,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02415,650,158 - 15,662,056 (-)NCBIUU_Cfam_GSD_1.0
BMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1715,749,835 - 15,761,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11715,750,487 - 15,762,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21717,052,609 - 17,064,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1231,349,394 - 31,361,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl231,348,808 - 31,360,901 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607113,190,629 - 13,202,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247417,706,236 - 7,719,484 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247417,706,205 - 7,717,677 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005320489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005320489   ⟹   XP_005320546
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBI
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005320546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3262860 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005320546   ⟸   XM_005320489
- UniProtKB: I3N300 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020624 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000018746 ENTREZGENE
  ENSSTOP00000018746.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020360.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene Bmp2 ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt I3N300 ENTREZGENE, UniProtKB/TrEMBL