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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735602
Species: Mus musculus
RGD Object: Gene
Symbol: Bmp2
Name: bone morphogenetic protein 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp2decreases expressionEXP 6480464CTDresveratrol results in decreased expression of BMP2 mRNAPMID:25338179
Bmp2increases expressionEXP 6480464CTDresveratrol results in increased expression of BMP2 mRNAPMID:17513867
Bmp2multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Resveratrol] results in increased expression of BMP2 mRNAPMID:29197120
Bmp2increases expressionISOBMP2 (Homo sapiens)6480464CTDresveratrol results in increased expression of BMP2 mRNA; resveratrol results in increased expression of BMP2 proteinPMID:17513867
Bmp2multiple interactionsISOBMP2 (Homo sapiens)6480464CTDAG 1879 inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; AG 1879 inhibits the reaction [resveratrol results in increased expression of BMP2 protein]; FOXA1 protein promotes the reaction [resveratrol results in increased expression of BMP2 protein]; fulvestrant inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]; fulvestrant inhibits the reaction [resveratrol results in increased expression of BMP2 mRNA]; resveratrol inhibits the reaction [TNF protein results in increased expression of BMP2 mRNA]; resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]; Tamoxifen inhibits the reaction [resveratrol promotes the reaction [ESR1 protein binds to BMP2 promoter]]PMID:16973825 PMID:17513867
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