Pklr (pyruvate kinase liver and red blood cell) - Rat Genome Database

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Gene: Pklr (pyruvate kinase liver and red blood cell) Mus musculus
Analyze
Symbol: Pklr
Name: pyruvate kinase liver and red blood cell
RGD ID: 11113
MGI Page MGI
Description: Exhibits pyruvate kinase activity. Involved in response to other organism. Localizes to cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study malaria and pyruvate kinase deficiency of red cells. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R); PARTICIPATES IN Fanconi syndrome pathway; forkhead class A signaling pathway; glycogen storage disease type VII pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L-PK; Pk; Pk-; Pk-1; Pk1; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; R-; R-PK
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,043,429 - 89,054,122 (+)NCBIGRCm39mm39
GRCm39 Ensembl389,043,449 - 89,054,091 (+)Ensembl
GRCm38389,136,122 - 89,146,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,136,142 - 89,146,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,940,064 - 88,950,516 (+)NCBIGRCm37mm9NCBIm37
MGSCv36389,222,069 - 89,231,560 (+)NCBImm8
Celera389,168,271 - 89,180,284 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bosentan  (ISO)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
cholesterol  (EXP)
choline  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethyl maleate  (ISO)
disodium selenite  (EXP)
duvoglustat  (EXP)
endosulfan  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (EXP,ISO)
fructose  (EXP,ISO)
furan  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
glycerol  (ISO)
hexadecanoic acid  (ISO)
hydroxyurea  (EXP)
isotretinoin  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
monosodium L-glutamate  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naloxone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-anisidine  (EXP)
p-toluidine  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
penconazole  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propamocarb  (EXP)
propane-1,2-diol  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
prostaglandin E2  (EXP)
quinidine  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sucrose  (EXP)
sulforaphane  (ISO)
sulprostone  (EXP)
suxibuzone  (ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (ISO,TAS)
plasma membrane  (IDA)

Molecular Function

References

References - curated
1. Andreasen CH, etal., BMC Med Genet. 2008 Dec 26;9:118. doi: 10.1186/1471-2350-9-118.
2. Becker W, etal., J Mol Endocrinol. 2004 Feb;32(1):195-208.
3. Canu G, etal., Blood Cells Mol Dis. 2016 Mar;57:100-9. doi: 10.1016/j.bcmd.2015.12.009. Epub 2016 Jan 12.
4. de Faatima Santana Ferreira Boin I, etal., Acta Cir Bras. 2006;21 Suppl 1:19-23.
5. Eddleston J, etal., Genomics 1999 Mar 1;56(2):149-59.
6. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
7. Hotta K, etal., Biochim Biophys Acta. 1996 Feb 9;1289(1):145-9.
8. Kanno H, etal., Blood. 1992 Mar 1;79(5):1347-50.
9. Kanno H, etal., Blood. 1994 Apr 15;83(8):2311-6.
10. Kanno H, etal., Blood. 1994 Nov 15;84(10):3505-9.
11. Kanno H, etal., Blood. 1995 Oct 15;86(8):3205-10.
12. Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
13. Machado P, etal., Br J Haematol. 2010 Jun;149(5):775-84. doi: 10.1111/j.1365-2141.2010.08165.x. Epub 2010 Apr 4.
14. Manco L, etal., Br J Haematol. 2000 Sep;110(4):993-7.
15. Meza NW, etal., Mol Ther. 2009 Dec;17(12):2000-9. doi: 10.1038/mt.2009.200. Epub 2009 Sep 15.
16. MGD and Homologene mouse data transfer
17. MGD data from the GO Consortium
18. MGD IEA
19. Min-Oo G, etal., Nat Genet. 2003 Dec;35(4):357-62. Epub 2003 Nov 2.
20. Mohammad S, etal., Can J Physiol Pharmacol. 2006 Jun;84(6):647-54.
21. OMIM Disease Annotation Pipeline
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. Pipeline to import SMPDB annotations from SMPDB into RGD
25. Pissard S, etal., Br J Haematol. 2006 Jun;133(6):683-9.
26. RGD automated import pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Riu E, etal., FASEB J. 2003 Sep;17(12):1715-7. Epub 2003 Jul 18.
30. Rockah R, etal., Am J Med Genet. 1998 Jul 7;78(3):233-6.
31. Serikawa T, etal., Genetics 1992 Jul;131(3):701-21.
32. Wang H, etal., Diabetes. 2002 Sep;51(9):2861-5.
33. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
34. Zhaofan X, etal., Burns. 2002 Nov;28(7):625-30.
Additional References at PubMed
PMID:1347284   PMID:1617222   PMID:1802805   PMID:2338144   PMID:2565740   PMID:2902233   PMID:6529440   PMID:7295297   PMID:7295298   PMID:7492793   PMID:7626896   PMID:7890684  
PMID:7915557   PMID:8268655   PMID:8398132   PMID:8467710   PMID:8661696   PMID:9490705   PMID:10049364   PMID:10349636   PMID:10886019   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:12466851   PMID:12477932   PMID:12819125   PMID:14681479   PMID:14706451   PMID:15155459   PMID:15616563   PMID:15967723   PMID:16141072   PMID:16141073   PMID:16263413   PMID:16498401  
PMID:16602821   PMID:17312006   PMID:17466543   PMID:17550844   PMID:17626619   PMID:17662887   PMID:17998386   PMID:18698006   PMID:19379695   PMID:19865104   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22566683   PMID:23078545   PMID:26562079   PMID:27125672   PMID:27215380   PMID:28245920   PMID:28542307  


Genomics

Comparative Map Data
Pklr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,043,429 - 89,054,122 (+)NCBIGRCm39mm39
GRCm39 Ensembl389,043,449 - 89,054,091 (+)Ensembl
GRCm38389,136,122 - 89,146,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,136,142 - 89,146,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,940,064 - 88,950,516 (+)NCBIGRCm37mm9NCBIm37
MGSCv36389,222,069 - 89,231,560 (+)NCBImm8
Celera389,168,271 - 89,180,284 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
PKLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1155,289,293 - 155,301,438 (-)EnsemblGRCh38hg38GRCh38
GRCh381155,289,293 - 155,301,438 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371155,259,084 - 155,271,229 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,526,254 - 153,537,835 (-)NCBINCBI36hg18NCBI36
Build 341152,072,702 - 152,084,298NCBI
Celera1128,332,260 - 128,344,368 (-)NCBI
Cytogenetic Map1q22NCBI
HuRef1126,621,396 - 126,633,527 (-)NCBIHuRef
CHM1_11156,654,499 - 156,666,666 (-)NCBICHM1_1
Pklr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,543,008 - 174,551,863 (+)NCBI
Rnor_6.0 Ensembl2188,449,210 - 188,459,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02188,449,158 - 188,458,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02207,865,529 - 207,874,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBICelera
RH 3.4 Map21154.4RGD
Cytogenetic Map2q34NCBI
Pklr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,739,152 - 1,749,632 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,742,432 - 1,749,632 (-)NCBIChiLan1.0ChiLan1.0
PKLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11134,239,565 - 134,250,957 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,239,565 - 134,251,351 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01130,634,111 - 130,646,644 (-)NCBIMhudiblu_PPA_v0panPan3
PKLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,263,899 - 42,272,770 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,263,761 - 42,272,755 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,754,768 - 41,762,716 (+)NCBI
ROS_Cfam_1.0742,132,983 - 42,141,903 (+)NCBI
UMICH_Zoey_3.1741,912,888 - 41,920,846 (+)NCBI
UNSW_CanFamBas_1.0741,966,693 - 41,974,641 (+)NCBI
UU_Cfam_GSD_1.0742,250,696 - 42,258,642 (+)NCBI
Pklr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,740,581 - 25,749,528 (-)NCBI
SpeTri2.0NW_0049365804,770,977 - 4,799,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,536,954 - 94,547,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,536,978 - 94,546,561 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,324,615 - 103,327,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PKLR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,540,228 - 8,547,184 (+)NCBI
ChlSab1.1 Ensembl208,540,763 - 8,545,884 (+)Ensembl
Pklr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248852,261,850 - 2,272,175 (+)NCBI

Position Markers
Pklr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,141,361 - 89,143,060UniSTSGRCm38
MGSCv37388,945,283 - 88,946,982UniSTSGRCm37
Celera389,175,051 - 89,176,750UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.0UniSTS
cM Map341.5UniSTS
UniSTS:234729  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,146,270 - 89,146,427UniSTSGRCm38
MGSCv37388,950,192 - 88,950,349UniSTSGRCm37
Celera389,179,960 - 89,180,117UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.0UniSTS
UniSTS:225291  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385147,875,670 - 147,875,771UniSTSGRCm38
MGSCv375148,687,246 - 148,687,347UniSTSGRCm37
Celera5145,871,208 - 145,871,309UniSTS
Celera389,171,274 - 89,171,375UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map5G3UniSTS
cM Map344.0UniSTS
PMC86965P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,136,152 - 89,136,280UniSTSGRCm38
MGSCv37388,940,074 - 88,940,202UniSTSGRCm37
Celera389,168,281 - 89,168,409UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.0UniSTS
Pklr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,145,487 - 89,145,607UniSTSGRCm38
MGSCv37388,949,409 - 88,949,529UniSTSGRCm37
Celera389,179,177 - 89,179,297UniSTS
Cytogenetic Map3F1UniSTS
cM Map341.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38726314789232787Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1365
Count of miRNA genes:557
Interacting mature miRNAs:669
Transcripts:ENSMUST00000047111, ENSMUST00000107482, ENSMUST00000127058, ENSMUST00000148097, ENSMUST00000151591
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047111   ⟹   ENSMUSP00000035417
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl389,136,142 - 89,146,594 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107482   ⟹   ENSMUSP00000103106
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl389,136,572 - 89,146,784 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127058   ⟹   ENSMUSP00000119392
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl389,136,579 - 89,141,539 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148097
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl389,136,623 - 89,140,912 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151591
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl389,136,174 - 89,137,459 (+)Ensembl
RefSeq Acc Id: NM_001099779   ⟹   NP_001093249
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,043,930 - 89,053,901 (+)NCBI
GRCm38389,136,623 - 89,146,594 (+)NCBI
MGSCv37388,940,064 - 88,950,516 (+)RGD
Celera389,168,271 - 89,180,284 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013631   ⟹   NP_038659
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,043,449 - 89,053,901 (+)NCBI
GRCm38389,136,142 - 89,146,594 (+)NCBI
MGSCv37388,940,064 - 88,950,516 (+)RGD
Celera389,168,271 - 89,180,284 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501134   ⟹   XP_006501197
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,043,824 - 89,054,122 (+)NCBI
GRCm38389,136,517 - 89,146,815 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501135   ⟹   XP_006501198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,043,429 - 89,054,122 (+)NCBI
GRCm38389,136,122 - 89,146,815 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038659   ⟸   NM_013631
- Peptide Label: isoform 1
- UniProtKB: G3X925 (UniProtKB/TrEMBL),   Q3UEH4 (UniProtKB/TrEMBL),   Q3UEI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001093249   ⟸   NM_001099779
- Peptide Label: isoform 2
- UniProtKB: E9Q509 (UniProtKB/TrEMBL),   Q3UEH4 (UniProtKB/TrEMBL),   Q3UEI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501198   ⟸   XM_006501135
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006501197   ⟸   XM_006501134
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000035417   ⟸   ENSMUST00000047111
RefSeq Acc Id: ENSMUSP00000103106   ⟸   ENSMUST00000107482
RefSeq Acc Id: ENSMUSP00000119392   ⟸   ENSMUST00000127058
Protein Domains
PK   PK_C

Promoters
RGD ID:6834252
Promoter ID:MM_KWN:34908
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_013631,   OTTMUST00000042490,   OTTMUST00000042491,   OTTMUST00000042492,   OTTMUST00000042493,   UC009VCP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,940,291 - 88,940,791 (+)MPROMDB
RGD ID:6881200
Promoter ID:EPDNEW_M4051
Type:initiation region
Name:Pklr_1
Description:Mus musculus pyruvate kinase liver and red blood cell , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4052  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38389,136,172 - 89,136,232EPDNEW
RGD ID:6881202
Promoter ID:EPDNEW_M4052
Type:initiation region
Name:Pklr_2
Description:Mus musculus pyruvate kinase liver and red blood cell , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4051  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38389,136,621 - 89,136,681EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97604 AgrOrtholog
Ensembl Genes ENSMUSG00000041237 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035417 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000103106 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000119392 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000047111 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000107482 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000127058 UniProtKB/TrEMBL
Gene3D-CATH 2.40.33.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1380.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Pyr_Knase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv/PenolPyrv_Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase-like_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18770 UniProtKB/TrEMBL
MGD MGI:97604 ENTREZGENE
NCBI Gene 18770 ENTREZGENE
PANTHER PTHR11817 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00224 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pklr PhenoGen
PRINTS PYRUVTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRUVATE_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51621 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52935 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs pyruv_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A7MCU9_MOUSE UniProtKB/TrEMBL
  D3Z2C4_MOUSE UniProtKB/TrEMBL
  E9Q509 ENTREZGENE, UniProtKB/TrEMBL
  G3X925 ENTREZGENE, UniProtKB/TrEMBL
  KPYR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UEH4 ENTREZGENE, UniProtKB/TrEMBL
  Q3UEI4 ENTREZGENE, UniProtKB/TrEMBL