Gnaq (guanine nucleotide binding protein, alpha q polypeptide) - Rat Genome Database

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Gene: Gnaq (guanine nucleotide binding protein, alpha q polypeptide) Mus musculus
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Symbol: Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
RGD ID: 1550022
MGI Page MGI
Description: Enables G protein activity and enzyme regulator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; maternal behavior; and neuron development. Located in cell body; dendrite; and membrane. Is active in plasma membrane and postsynaptic cytosol. Is expressed in several structures, including central nervous system; gonad; heart; intestine smooth muscle circular layer; and retina. Used to study congestive heart failure and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; congestive heart failure; and familial multiple nevi flammei. Orthologous to human GNAQ (G protein subunit alpha q).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; Dsk; Dsk1; Dsk10; G alpha q; Gal; Galphaq; Gq; GqI; guanine nucleotide-binding protein alpha-q; guanine nucleotide-binding protein G(q) subunit alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391916,110,048 - 16,365,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)EnsemblGRCm39 Ensembl
GRCm381916,132,684 - 16,388,520 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371916,207,321 - 16,461,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361916,199,850 - 16,454,472 (+)NCBIMGSCv36mm8
MGSCv361915,738,354 - 16,003,046 (+)NCBIMGSCv36mm8
Celera1916,873,630 - 17,041,492 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map1911.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
GnaqMouseCardiomegaly  IDA 1598475 RGD 
GnaqMousecongestive heart failure disease_progressionISOGNAQ (Homo sapiens)126781754DNA:polymorphism:promoter:[-694C>T and -695G>T] (human)RGD 
GnaqMousecongestive heart failure no_associationISOGNAQ (Homo sapiens)126781754DNA:polymorphisms:promoter:multipleRGD 
GnaqMouseCraniofacial Abnormalities  IMP 737757 RGD 
GnaqMousedilated cardiomyopathy  IDA 1598475 RGD 
GnaqMouselung non-small cell carcinoma disease_progressionISOGNAQ (Homo sapiens)126781753 RGD 
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Original Reference(s)
GnaqMouseCardiovascular Abnormalities  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of cardiovascular system morphologyClinVarPMID:25741868
GnaqMousefamilial multiple nevi flammei  ISOGNAQ (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23656586 more ...
GnaqMousegenetic disease  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
GnaqMouseKlippel-Trenaunay syndrome  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: Angio-osteohypertrophy syndromeClinVarPMID:23656586 more ...
GnaqMousemelanoma  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: MelanomaClinVarPMID:1328859 more ...
GnaqMousemelanoma  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: MelanomaClinVarPMID:23656586 more ...
GnaqMouseNeu-Laxova syndrome 2  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: Neu-Laxova syndrome 2ClinVarPMID:17436247 more ...
GnaqMousePort-Wine Stain  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: PORT-WINE STAINClinVarPMID:23656586 more ...
GnaqMouseSturge-Weber syndrome  ISOGNAQ (Homo sapiens)8554872ClinVar Annotator: match by term: Sturge-Weber syndromeClinVarPMID:23656586 more ...
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Original Reference(s)
GnaqMouseAlbuminuria  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16267159
GnaqMouseblood coagulation disease  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9296496
GnaqMousecongenital heart disease  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9687499
GnaqMouseCraniofacial Abnormalities  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9687499
GnaqMousefocal segmental glomerulosclerosis  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16267159
GnaqMousemelanoma  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23432625
GnaqMousePort-Wine Stain  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23656586
GnaqMouseSturge-Weber syndrome  ISOGNAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23656586
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Original Reference(s)
GnaqMousecongestive heart failure  IAGP 13592920 MouseDO 
GnaqMousedilated cardiomyopathy  IAGP 13592920 MouseDO 
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Original Reference(s)
GnaqMousefamilial multiple nevi flammei  ISOGNAQ (Homo sapiens)7240710 OMIM 
GnaqMouseSturge-Weber syndrome  ISOGNAQ (Homo sapiens)7240710 OMIM 

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Original Reference(s)
GnaqMouse(-)-epigallocatechin 3-gallate multiple interactionsISOGNAQ (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GNAQ mRNACTDPMID:22079256
GnaqMouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of GNAQ mRNACTDPMID:22206623
GnaqMouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GNAQ mRNACTDPMID:22206623
GnaqMouse17alpha-ethynylestradiol increases expressionISOGnaq (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of GNAQ mRNACTDPMID:29097150
GnaqMouse17beta-estradiol multiple interactionsISOGNAQ (Homo sapiens)6480464Estradiol promotes the reaction [ESR1 protein binds to GNAQ protein] and Estradiol promotes the reaction [GNAQ protein binds to ESR1 protein]CTDPMID:23665804 more ...
GnaqMouse17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactionsISOGNAQ (Homo sapiens)6480464[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form]CTDPMID:28751236
GnaqMouse17beta-hydroxy-5alpha-androstan-3-one increases expressionISOGNAQ (Homo sapiens)6480464Dihydrotestosterone results in increased expression of GNAQ mRNACTDPMID:29581250
GnaqMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of GNAQ mRNACTDPMID:21570461
GnaqMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOGnaq (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of GNAQ mRNACTDPMID:32109520
GnaqMouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOGnaq (Rattus norvegicus)64804642 more ...CTDPMID:32109520
GnaqMouse2,6-dimethoxyphenol multiple interactionsISOGNAQ (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of GNAQ proteinCTDPMID:38598786
GnaqMouse2-bromohexadecanoic acid multiple interactionsISOGNAQ (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of GNAQ protein]CTDPMID:38195004
GnaqMouse2-methylcholine affects expressionISOGNAQ (Homo sapiens)6480464beta-methylcholine affects the expression of GNAQ mRNACTDPMID:21179406
GnaqMouse2-nitrotoluene decreases expressionISOGnaq (Rattus norvegicus)64804642-nitrotoluene results in decreased expression of GNAQ mRNACTDPMID:16460773
GnaqMouse3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases response to substanceEXP 6480464GNAQ protein results in increased susceptibility to Puromycin AminonucleosideCTDPMID:16267159
GnaqMouse3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of GNAQ mRNACTDPMID:20188158
GnaqMouse4,4'-sulfonyldiphenol multiple interactionsISOGNAQ (Homo sapiens)6480464bisphenol S inhibits the reaction [ESR1 protein binds to GNAQ protein]CTDPMID:29389661
GnaqMouse4,4'-sulfonyldiphenol affects expressionISOGNAQ (Homo sapiens)6480464bisphenol S affects the expression of GNAQ proteinCTDPMID:31945527
GnaqMouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of GNAQ mRNACTDPMID:39298647
GnaqMouse4-hydroxynon-2-enal increases expressionEXP 64804644-hydroxy-2-nonenal results in increased expression of GNAQ mRNACTDPMID:19191707

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Biological Process
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Original Reference(s)
GnaqMouseaction potential acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:10818132MGIPMID:10818132
GnaqMouseadenylate cyclase-activating G protein-coupled receptor signaling pathway acts_upstream_of_or_withinIDA 2290270 PMID:10481072MGIPMID:10481072
GnaqMouseadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIBAPANTHER:PTN008496048 and MGI:957762290270 GO_CentralGO_REF:0000033
GnaqMousecranial skeletal system development involved_inIGIMGI:95766 and MGI:957762290270 PMID:18199583MGIPMID:18199583
GnaqMousedevelopmental pigmentation acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:15322542MGIPMID:15322542
GnaqMouseembryonic digit morphogenesis acts_upstream_of_or_withinIGIMGI:957672290270 PMID:12077299MGIPMID:12077299
GnaqMouseendothelin receptor signaling pathway involved_inIGIMGI:957662290270 PMID:18199583MGIPMID:18199583
GnaqMouseforebrain neuron development acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:15340067MGIPMID:15340067
GnaqMouseG protein-coupled receptor signaling pathway acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:9687499MGIPMID:9687499
GnaqMouseglutamate receptor signaling pathway acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:11438569MGIPMID:11438569
GnaqMouseglutamate receptor signaling pathway involved_inIBAPANTHER:PTN008496048 more ...2290270 GO_CentralGO_REF:0000033
GnaqMouseheart development acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:9687499MGIPMID:9687499
GnaqMouseligand-gated ion channel signaling pathway involved_inIMP 2290270 PMID:26075576MGIPMID:26075576
GnaqMouseligand-gated ion channel signaling pathway involved_inIGIMGI:957662290270 PMID:20440069MGIPMID:20440069
GnaqMousematernal behavior acts_upstream_of_or_withinIMPMGI:21516612290270 PMID:15340067MGIPMID:15340067
GnaqMousenegative regulation of apoptotic process  ISOGnaq (Rattus norvegicus)9068941 RGDPMID:16466740 and REF_RGD_ID:1581905
GnaqMousenegative regulation of apoptotic process involved_inISOGnaq (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
GnaqMousenegative regulation of potassium ion transport  ISOGnaq (Rattus norvegicus)9068941 RGDPMID:9614229 and REF_RGD_ID:1598491
GnaqMousenegative regulation of potassium ion transport involved_inISOGnaq (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
GnaqMousenegative regulation of protein kinase activity involved_inISOUniProtKB:P501482290270 GO_CentralGO_REF:0000119
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Cellular Component
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Original Reference(s)
GnaqMousecaveola  ISOGnaq (Rattus norvegicus)9068941 RGDPMID:16730745 and REF_RGD_ID:1598488
GnaqMousecaveola located_inISOGnaq (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
GnaqMousecell body located_inIDA 2290270 PMID:11685543MGIPMID:11685543
GnaqMousecytoplasm is_active_inIBAPANTHER:PTN000026392 more ...2290270 GO_CentralGO_REF:0000033
GnaqMousedendrite located_inIDA 2290270 PMID:11685543MGIPMID:11685543
GnaqMouseGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01322290270 UniProtGO_REF:0000044
GnaqMouseheterotrimeric G-protein complex part_ofIBAPANTHER:PTN000026392 more ...2290270 GO_CentralGO_REF:0000033
GnaqMouseheterotrimeric G-protein complex part_ofISOUniProtKB:P824712290270 PMID:21812758MGIPMID:21812758
GnaqMouseheterotrimeric G-protein complex part_ofTAS 2290270 PMID:9391157 and PMID:9687499MGIPMID:9391157 and PMID:9687499
GnaqMousemembrane located_inIDA 2290270 PMID:9016340MGIPMID:9016340
GnaqMousenuclear membrane located_inIEAUniProtKB-SubCell:SL-01822290270 UniProtGO_REF:0000044
GnaqMouseplasma membrane located_inTAS 2290270 ReactomeReactome:R-MMU-426547 more ...
GnaqMouseplasma membrane is_active_inIDA 2290270 PMID:9765251MGIPMID:9765251
GnaqMouseplasma membrane is_active_inISOUniProtKB:P501482290270 PMID:16754659MGIPMID:16754659
GnaqMousepostsynaptic cytosol is_active_inIDA 2290270 PMID:27276689UniProtPMID:27276689
GnaqMousepresynapse is_active_inISOGnaq (Rattus norvegicus)9068941PMID:17144906SynGOPMID:17144906 and REF_RGD_ID:405650370
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Molecular Function
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GnaqMousealkylglycerophosphoethanolamine phosphodiesterase activity enablesISOUniProtKB:P824712290270 PMID:21812758MGIPMID:21812758
GnaqMouseenzyme regulator activity enablesIDA 2290270 PMID:37991948UniProtPMID:37991948
GnaqMouseenzyme regulator activity enablesIMP 2290270 PMID:26075576MGIPMID:26075576
GnaqMouseenzyme regulator activity enablesISOUniProtKB:P501482290270 PMID:26628681MGIPMID:26628681
GnaqMouseG protein activity enablesISOUniProtKB:P501482290270 PMID:26628681MGIPMID:26628681
GnaqMouseG protein activity enablesIDA 2290270 PMID:20966218 and PMID:37991948UniProtPMID:20966218 and PMID:37991948
GnaqMouseG protein activity enablesIMP 2290270 PMID:26075576MGIPMID:26075576
GnaqMouseG protein-coupled receptor binding enablesIBAPANTHER:PTN000026392 more ...2290270 GO_CentralGO_REF:0000033
GnaqMouseG protein-coupled receptor binding enablesIEAInterPro:IPR0006542290270 InterProGO_REF:0000002
GnaqMouseG-protein beta/gamma-subunit complex binding enablesIBAPANTHER:PTN000026392 and MGI:957782290270 GO_CentralGO_REF:0000033
GnaqMouseG-protein beta/gamma-subunit complex binding enablesIEAInterPro:IPR0010192290270 InterProGO_REF:0000002
GnaqMouseGTP binding enablesIEAUniProtKB-KW:KW-03422290270 UniProtGO_REF:0000043
GnaqMouseGTPase activator activity enablesISOUniProtKB:P501482290270 GO_CentralGO_REF:0000119
GnaqMouseGTPase activator activity enablesIBAPANTHER:PTN002566458 and UniProtKB:P501482290270 GO_CentralGO_REF:0000033
GnaqMouseGTPase activity enablesIBAPANTHER:PTN000026392 more ...2290270 GO_CentralGO_REF:0000033
GnaqMouseGTPase activity enablesTAS 2290270 PMID:9391157 and PMID:9687499MGIPMID:9391157 and PMID:9687499
GnaqMousemetal ion binding enablesIEAUniProtKB-KW:KW-04792290270 UniProtGO_REF:0000043
GnaqMouseprotein binding enablesIPIUniProtKB:P412202290270 PMID:19478087UniProtPMID:19478087
GnaqMouseprotein binding enablesIPIPR:Q616162290270 PMID:9016340MGIPMID:9016340
GnaqMouseprotein binding enablesIPIPR:Q8VHN72290270 PMID:24191038MGIPMID:24191038
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RGD Manual Annotations

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Imported Annotations - KEGG (archival)

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Original Reference(s)
GnaqMouseAlzheimer's disease pathway   IEA 6907045 KEGGmmu:05010
GnaqMouseChagas disease pathway  IEA 6907045 KEGGmmu:05142
GnaqMouseEntamoebiasis pathway  IEA 6907045 KEGGmmu:05146
GnaqMouseglutamate signaling pathway  IEA 6907045 KEGGmmu:04724
GnaqMousegonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGmmu:04912
GnaqMouseHuntington's disease pathway   IEA 6907045 KEGGmmu:05016
GnaqMouselong term depression  IEA 6907045 KEGGmmu:04730
GnaqMouselong term potentiation  IEA 6907045 KEGGmmu:04720
GnaqMousesleeping sickness pathway  IEA 6907045 KEGGmmu:05143
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Imported Annotations - PID (archival)

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GnaqMouseabnormal afterhyperpolarization  IAGP 5509061 MGIPMID:11826096
GnaqMouseabnormal alisphenoid bone morphology  IAGP 5509061 MGIPMID:18199583
GnaqMouseabnormal blood coagulation  IAGP 5509061 MGIPMID:11689889
GnaqMouseabnormal bone mineralization  IAGP 5509061 MGIPMID:16988000
GnaqMouseabnormal breathing pattern  IAGP 5509061 MGIPMID:9687499
GnaqMouseabnormal circulating calcium level  IAGP 5509061 MGIPMID:16988000
GnaqMouseabnormal dermal pigmentation  IAGP 5509061 MGIPMID:26763459
GnaqMouseabnormal epidermal pigmentation  IAGP 5509061 MGIPMID:26763459
GnaqMouseabnormal epiphyseal plate morphology  IAGP 5509061 MGIPMID:16988000
GnaqMouseabnormal glutamate-mediated receptor currents  IAGP 5509061 MGIPMID:11826096
GnaqMouseabnormal heart size  IAGP 5509061 MGIPMID:9687499
GnaqMouseabnormal hyoid bone morphology  IAGP 5509061 MGIPMID:18199583
GnaqMouseabnormal innervation  IAGP 5509061 MGIPMID:9391157
GnaqMouseabnormal larynx morphology  IAGP 5509061 MGIPMID:16988000
GnaqMouseabnormal motor coordination/balance  IAGP 5509061 MGIPMID:11689889
GnaqMouseabnormal nervous system electrophysiology  IAGP 5509061 MGIPMID:11826096
GnaqMouseabnormal nervous system electrophysiology  IAGP 5509061 MGIPMID:17482476
GnaqMouseabnormal palatine bone morphology  IAGP 5509061 MGIPMID:18199583
GnaqMouseabnormal parathyroid gland morphology  IAGP 5509061 MGIPMID:16988000
GnaqMouseabnormal platelet physiology  IAGP 5509061 MGIPMID:9296496
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Reference Title
Reference Citation
1. Molecular properties of muscarinic acetylcholine receptors. Haga T Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(6):226-56.
2. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Holmes CL, etal., Crit Care. 2003 Dec;7(6):427-34. Epub 2003 Jun 26.
3. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Hunyady L and Catt KJ, Mol Endocrinol. 2006 May;20(5):953-70. Epub 2005 Sep 1.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Liggett SB, etal., Hum Mol Genet. 2007 Nov 15;16(22):2740-50. doi: 10.1093/hmg/ddm229. Epub 2007 Aug 24.
6. Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Mende U, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. Ocak S, etal., J Thorac Oncol. 2014 Mar;9(3):324-36. doi: 10.1097/JTO.0000000000000090.
10. Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
19. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
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PMID:1302014   PMID:2123549   PMID:7642703   PMID:8227063   PMID:8588930   PMID:8825633   PMID:8858601   PMID:8889548   PMID:8999798   PMID:9016340   PMID:9020153   PMID:9223268  
PMID:9223325   PMID:9296496   PMID:9391157   PMID:9554846   PMID:9607776   PMID:9640335   PMID:9765251   PMID:10037795   PMID:10349636   PMID:10433197   PMID:10481072   PMID:10629036  
PMID:10818132   PMID:10829070   PMID:10864945   PMID:10922068   PMID:10926822   PMID:11042159   PMID:11076861   PMID:11113135   PMID:11245652   PMID:11342430   PMID:11389023   PMID:11438569  
PMID:11685543   PMID:11689889   PMID:11826096   PMID:11891332   PMID:11907117   PMID:11985591   PMID:12077299   PMID:12183468   PMID:12351712   PMID:12397184   PMID:12411459   PMID:12477932  
PMID:12533510   PMID:12586747   PMID:12604601   PMID:12611815   PMID:12639992   PMID:12648486   PMID:12771155   PMID:12829380   PMID:12900409   PMID:12952937   PMID:12954641   PMID:14595844  
PMID:14630933   PMID:14742685   PMID:14755341   PMID:14976183   PMID:15175381   PMID:15304043   PMID:15322542   PMID:15326177   PMID:15340067   PMID:15367435   PMID:15466861   PMID:15489334  
PMID:15505105   PMID:15579147   PMID:15713647   PMID:15774906   PMID:15872115   PMID:15878957   PMID:15936338   PMID:16141072   PMID:16141073   PMID:16186103   PMID:16210321   PMID:16217033  
PMID:16223779   PMID:16251183   PMID:16339032   PMID:16354929   PMID:16380388   PMID:16504475   PMID:16602821   PMID:16754659   PMID:16847339   PMID:16988000   PMID:17023430   PMID:17088245  
PMID:17194762   PMID:17199045   PMID:17287521   PMID:17371949   PMID:17482476   PMID:17493641   PMID:17694176   PMID:17823129   PMID:17873012   PMID:17895403   PMID:17938235   PMID:18021799  
PMID:18084302   PMID:18199583   PMID:18213612   PMID:18219172   PMID:18237278   PMID:18353977   PMID:18473122   PMID:18487437   PMID:18552456   PMID:18667730   PMID:18674539   PMID:18801931  
1 to 10 of 23 rows



Gnaq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391916,110,048 - 16,365,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)EnsemblGRCm39 Ensembl
GRCm381916,132,684 - 16,388,520 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv371916,207,321 - 16,461,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361916,199,850 - 16,454,472 (+)NCBIMGSCv36mm8
MGSCv361915,738,354 - 16,003,046 (+)NCBIMGSCv36mm8
Celera1916,873,630 - 17,041,492 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map1911.01NCBI
GNAQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38977,716,097 - 78,031,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl977,716,097 - 78,031,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37980,331,013 - 80,646,727 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36979,525,009 - 79,836,012 (-)NCBINCBI36Build 36hg18NCBI36
Build 34977,564,746 - 77,875,746NCBI
Celera950,912,294 - 51,223,287 (-)NCBICelera
Cytogenetic Map9q21.2NCBI
HuRef950,167,421 - 50,477,535 (-)NCBIHuRef
CHM1_1980,482,435 - 80,793,672 (-)NCBICHM1_1
T2T-CHM13v2.0989,873,050 - 90,188,930 (-)NCBIT2T-CHM13v2.0
Gnaq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,852,453 - 223,098,754 (+)NCBIGRCr8
mRatBN7.21213,425,631 - 213,671,947 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1213,424,465 - 213,667,672 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,757,414 - 222,003,643 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,689,512 - 228,935,809 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,511,974 - 221,758,205 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01233,382,778 - 233,622,584 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1233,382,708 - 233,622,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,497,178 - 240,736,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,520,998 - 219,764,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,685,020 - 219,928,420 (+)NCBI
Celera1210,763,138 - 211,002,668 (+)NCBICelera
Cytogenetic Map1q43NCBI
Gnaq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555121,381,159 - 1,658,409 (+)NCBIChiLan1.0ChiLan1.0
LOC100986730
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21176,877,498 - 77,190,897 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1976,883,323 - 77,196,700 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0946,816,409 - 47,129,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1976,570,773 - 76,773,847 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl976,575,815 - 76,773,849 (-)Ensemblpanpan1.1panPan2
GNAQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1180,733,530 - 80,928,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl180,715,366 - 80,928,065 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,197,285 - 81,391,732 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,038,541 - 81,345,574 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,038,966 - 81,343,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1180,931,602 - 81,126,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0180,652,980 - 80,847,487 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,383,410 - 81,578,003 (+)NCBIUU_Cfam_GSD_1.0
LOC101971998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947127,896,936 - 128,074,513 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650313,099,558 - 13,276,152 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650313,098,517 - 13,276,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1230,605,265 - 230,907,674 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11230,607,469 - 230,906,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21257,372,859 - 257,378,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNAQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11288,666,375 - 88,988,989 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1288,670,424 - 88,871,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603876,997,006 - 77,320,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnaq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248115,163,793 - 5,486,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248115,158,665 - 5,485,812 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gnaq
7765 total Variants

Predicted Target Of
Summary Value
Count of predictions:1836
Count of miRNA genes:770
Interacting mature miRNAs:1048
Transcripts:ENSMUST00000025541, ENSMUST00000167656, ENSMUST00000170229
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse

1 to 10 of 21 rows
RH127065  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,371,180 - 16,371,396UniSTSGRCm38
MGSCv371916,445,670 - 16,445,886UniSTSGRCm37
Celera1917,025,229 - 17,025,445UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Whitehead/MRC_RH19176.74UniSTS
RH136177  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,314,711 - 16,314,910UniSTSGRCm38
MGSCv371916,389,201 - 16,389,400UniSTSGRCm37
Celera1916,968,583 - 16,968,782UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
AW060788  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,385,140 - 16,385,260UniSTSGRCm38
MGSCv371916,459,630 - 16,459,750UniSTSGRCm37
Celera1917,039,179 - 17,039,299UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Whitehead/MRC_RH19176.12UniSTS
Gnaq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371916,457,861 - 16,458,183UniSTSGRCm37
Celera1917,037,420 - 17,037,742UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
02.MMHAP85FRA8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,220,016 - 16,220,177UniSTSGRCm38
MGSCv371916,294,506 - 16,294,667UniSTSGRCm37
Celera1916,874,090 - 16,874,251UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Whitehead_YAC19 UniSTS
D19Mit52  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,146,324 - 16,146,460UniSTSGRCm38
MGSCv371916,220,814 - 16,220,950UniSTSGRCm37
Celera1916,798,688 - 16,798,824UniSTS
Cytogenetic Map19AUniSTS
cM Map198.0UniSTS
Whitehead Genetic199.8UniSTS
Whitehead/MRC_RH19174.41UniSTS
Whitehead_YAC19 UniSTS
RH124695  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,388,228 - 16,388,480UniSTSGRCm38
MGSCv371916,462,718 - 16,462,970UniSTSGRCm37
Celera1917,042,267 - 17,042,519UniSTS
Cytogenetic Map19AUniSTS
cM Map199.0UniSTS
Gnaq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381916,383,371 - 16,383,693UniSTSGRCm38
MGSCv371916,457,861 - 16,458,183UniSTSGRCm37
Celera1917,037,420 - 17,037,742UniSTS
Cytogenetic Map19AUniSTS







Ensembl Acc Id: ENSMUST00000025541   ⟹   ENSMUSP00000025541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1916,110,195 - 16,364,827 (+)Ensembl
GRCm38.p6 Ensembl1916,132,831 - 16,387,463 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1916,196,996 - 16,294,638 (+)Ensembl
GRCm38.p6 Ensembl1916,219,632 - 16,317,274 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1916,110,660 - 16,293,891 (+)Ensembl
GRCm38.p6 Ensembl1916,133,296 - 16,316,527 (+)Ensembl
RefSeq Acc Id: NM_008139   ⟹   NP_032165
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391916,110,048 - 16,365,884 (+)NCBI
GRCm381916,132,684 - 16,388,520 (+)NCBI
MGSCv371916,207,321 - 16,461,943 (+)RGD
Celera1916,873,630 - 17,041,492 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein RefSeqs NP_032165 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63306 (Get FASTA)   NCBI Sequence Viewer  
  AAH57583 (Get FASTA)   NCBI Sequence Viewer  
  BAE27882 (Get FASTA)   NCBI Sequence Viewer  
  EDL41539 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025541
  ENSMUSP00000025541.6
GenBank Protein P21279 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032165   ⟸   NM_008139
- UniProtKB: Q6PFF5 (UniProtKB/Swiss-Prot),   P21279 (UniProtKB/Swiss-Prot),   Q3UHH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025541   ⟸   ENSMUST00000025541
G-alpha

Name Modeler Protein Id AA Range Protein Structure
AF-P21279-F1-model_v2 AlphaFold P21279 1-359 view protein structure

RGD ID:13679048
Promoter ID:EPDNEW_M23673
Type:initiation region
Name:Gnaq_1
Description:Mus musculus guanine nucleotide binding protein, alpha q polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381916,132,880 - 16,132,940EPDNEW
RGD ID:6830098
Promoter ID:MM_KWN:26578
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_008139
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361916,206,751 - 16,207,917 (+)MPROMDB


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000024639 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025541 ENTREZGENE
  ENSMUST00000025541.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Gprotein_alpha_Q UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:14682 UniProtKB/Swiss-Prot
MGD MGI:95776 ENTREZGENE
NCBI Gene 14682 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PhenoGen Gnaq PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAQ UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt GNAQ_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UHH5 ENTREZGENE, UniProtKB/TrEMBL
  Q6PFF5 ENTREZGENE
UniProt Secondary Q6PFF5 UniProtKB/Swiss-Prot
1 to 26 of 26 rows