Ren1 (renin 1 structural) - Rat Genome Database

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Gene: Ren1 (renin 1 structural) Mus musculus
Symbol: Ren1
Name: renin 1 structural
RGD ID: 1332384
Description: Enables endopeptidase activity. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; male gonad development; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensinogenase; aspartyl-protease; D19352; kidney renin; R; Re; Ren; Ren-1; Ren-A; Ren1c; Ren1d; renin b; renin-1; Rn; Rn-1; Rnr
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBImm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Albuminuria  (ISO)
anemia  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 4  (ISO)
Azotemia  (ISO)
Bartter disease  (ISO)
Cardiomegaly  (IEP,ISO)
chronic fatigue syndrome  (ISO)
colitis  (IMP)
congenital adrenal hyperplasia  (ISO)
congestive heart failure  (ISO)
Critical Illness  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (IEP,ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial juvenile hyperuricemic nephropathy  (ISS)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
hand, foot and mouth disease  (ISO)
Hemorrhage  (ISO)
hepatoblastoma  (ISO)
human cytomegalovirus infection  (ISO)
hypertension  (IEP,IMP,ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (IMP)
Left Ventricular Hypertrophy  (ISO)
Liddle syndrome  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
mental depression  (ISO)
myocardial infarction  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
parathyroid carcinoma  (ISO)
periodontal disease  (IMP)
portal hypertension  (ISO)
Preeclamptic Toxemia  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (IEP,ISO)
Retina Reperfusion Injury  (ISO)
toxic shock syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-Phenylaminoadenosine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol  (ISO)
6alpha-methylprednisolone  (ISO)
acebutolol  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
aliskiren  (ISO)
all-trans-retinoic acid  (EXP)
alpha-methyl-L-dopa  (ISO)
alprenolol  (ISO)
aluminium phosphide  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
atenolol  (ISO)
benazepril  (ISO)
bendroflumethiazide  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
bumetanide  (EXP,ISO)
bunitrolol  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin a  (ISO)
candesartan  (ISO)
carvedilol  (ISO)
celecoxib  (ISO)
CGS-21680  (ISO)
chlordecone  (EXP)
chlorisondamine  (ISO)
chlorthalidone  (ISO)
choline  (EXP)
cilazapril monohydrate  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
cortisol  (ISO)
Cuprizon  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
desflurane  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (ISO)
dihydralazine  (ISO)
diltiazem  (ISO)
dobutamine  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (ISO)
endralazine  (ISO)
esmolol  (ISO)
ethanol  (ISO)
fenoterol  (ISO)
fentanyl  (ISO)
folic acid  (EXP)
furosemide  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycidol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
Guanfacine  (ISO)
halothane  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
ICI 118551  (ISO)
indapamide  (ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
iooxitalamic acid  (ISO)
irbesartan  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP,ISO)
Isradipine  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
ketoprofen  (ISO)
L-methionine  (EXP)
labetalol  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (ISO)
losartan  (EXP,ISO)
magnesium sulfate  (ISO)
meclofenamic acid  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
milrinone  (EXP)
minoxidil  (ISO)
ML-7  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
naproxen  (ISO)
nebivolol  (ISO)
nicardipine  (ISO)
nifedipine  (ISO)
Nilvadipine  (ISO)
nitrendipine  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitroglycerin  (ISO)
nitroprusside  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP)
pentobarbital  (ISO)
perindopril  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pindolol  (ISO)
piperidines  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
practolol  (ISO)
prazosin  (ISO)
probenecid  (ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
quercetin  (ISO)
quinapril hydrochloride  (ISO)
rac-lactic acid  (ISO)
ramipril  (EXP,ISO)
ranitidine  (ISO)
reboxetine  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
ritodrine  (ISO)
sildenafil citrate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium atom  (EXP,ISO)
sodium chloride  (EXP,ISO)
soyasaponin I  (ISO)
Soyasaponin II  (ISO)
spirapril  (ISO)
spironolactone  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
tienilic acid  (ISO)
titanium dioxide  (ISO)
torasemide  (ISO)
trandolapril  (ISO)
trichloroethene  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
yohimbine  (ISO)


References - curated
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2. Alderman MH, etal., N Engl J Med. 1991 Apr 18;324(16):1098-104.
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10. Gleeson PJ, etal., Crit Care Med. 2019 Feb;47(2):152-158. doi: 10.1097/CCM.0000000000003544.
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18. Meurer M, etal., Pflugers Arch. 2018 Nov;470(11):1691-1703. doi: 10.1007/s00424-018-2183-3. Epub 2018 Jul 19.
19. MGD and Homologene mouse data transfer
20. MGD data from the GO Consortium
22. Nguyen G, Kidney Int. 2006 May;69(9):1503-6.
23. Nguyen LS, etal., Eur J Endocrinol. 2019 Nov;181(5):481-488. doi: 10.1530/EJE-19-0379.
24. Nguyen M, etal., Shock. 2019 Oct;52(4):e22-e30. doi: 10.1097/SHK.0000000000001285.
25. Oka M, etal., Hypertension. 2017 Jul;70(1):119-128. doi: 10.1161/HYPERTENSIONAHA.117.09283. Epub 2017 May 22.
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28. OMIM Disease Annotation Pipeline
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31. Pipeline to import KEGG annotations from KEGG into RGD
32. Pipeline to import SMPDB annotations from SMPDB into RGD
33. RGD automated import pipeline
34. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:15253   PMID:1295871   PMID:1311969   PMID:1315816   PMID:1317108   PMID:1358796   PMID:1736303   PMID:1889815   PMID:1916990   PMID:1970800   PMID:1981051   PMID:2172970  
PMID:2571577   PMID:2575484   PMID:2685761   PMID:2691339   PMID:2725513   PMID:2833727   PMID:2878091   PMID:2882954   PMID:2885153   PMID:2894402   PMID:2895697   PMID:2971731  
PMID:3384439   PMID:3416634   PMID:3898081   PMID:6089205   PMID:6095465   PMID:6327268   PMID:6327270   PMID:6337154   PMID:6357783   PMID:6370686   PMID:6378791   PMID:6389258  
PMID:6392850   PMID:6751556   PMID:7028030   PMID:7031061   PMID:7165695   PMID:7545711   PMID:7558021   PMID:7587381   PMID:7604960   PMID:7637256   PMID:8001974   PMID:8012113  
PMID:8188220   PMID:8288230   PMID:8408633   PMID:8486351   PMID:8798416   PMID:8952516   PMID:8995758   PMID:9030738   PMID:9107685   PMID:9218454   PMID:9622149   PMID:9690204  
PMID:9693135   PMID:9828134   PMID:9876285   PMID:9933256   PMID:9973259   PMID:10318840   PMID:10322631   PMID:10349636   PMID:10405217   PMID:10575213   PMID:10585461   PMID:10615411  
PMID:10617578   PMID:10672905   PMID:10729219   PMID:10995772   PMID:11015607   PMID:11042159   PMID:11074015   PMID:11076861   PMID:11145610   PMID:11161799   PMID:11217851   PMID:11395546  
PMID:11457727   PMID:11751275   PMID:12080069   PMID:12163396   PMID:12381922   PMID:12431444   PMID:12466851   PMID:12477932   PMID:12591615   PMID:12617826   PMID:12909574   PMID:14563659  
PMID:14563845   PMID:14583438   PMID:15063178   PMID:15075180   PMID:15130496   PMID:15322704   PMID:15489334   PMID:15533830   PMID:15545507   PMID:15563565   PMID:15695374   PMID:15857826  
PMID:15944188   PMID:16007255   PMID:16141072   PMID:16141073   PMID:16446393   PMID:16498405   PMID:16738017   PMID:16822937   PMID:16895910   PMID:16990260   PMID:17442791   PMID:17641813  
PMID:17846348   PMID:17898695   PMID:18054319   PMID:18055510   PMID:18259612   PMID:18287559   PMID:18307722   PMID:18483625   PMID:18535668   PMID:18579650   PMID:19034301   PMID:19047580  
PMID:19073828   PMID:19139376   PMID:19252086   PMID:19261741   PMID:19293336   PMID:19443644   PMID:19474190   PMID:19521566   PMID:19710239   PMID:19822797   PMID:19884258   PMID:19998061  
PMID:20056748   PMID:20065157   PMID:20093323   PMID:20164204   PMID:20660994   PMID:20686449   PMID:20861226   PMID:21189370   PMID:21209011   PMID:21239248   PMID:21267068   PMID:21389089  
PMID:21499941   PMID:21565284   PMID:21677750   PMID:21708949   PMID:21750232   PMID:21873635   PMID:22278040   PMID:22357914   PMID:22441348   PMID:22496664   PMID:22523253   PMID:22645148  
PMID:22785482   PMID:23117547   PMID:23235568   PMID:23297374   PMID:23393316   PMID:23401498   PMID:23635510   PMID:23698720   PMID:23702969   PMID:23769837   PMID:24262755   PMID:24549417  
PMID:24614215   PMID:24652800   PMID:24734888   PMID:24740792   PMID:24904091   PMID:25122048   PMID:25241776   PMID:25249154   PMID:25587709   PMID:26062877   PMID:26107632   PMID:26108870  
PMID:26180185   PMID:26246508   PMID:26295797   PMID:26438731   PMID:26502369   PMID:27271344   PMID:27467376   PMID:27754863   PMID:27861631   PMID:27917469   PMID:28527294   PMID:28665931  
PMID:28701311   PMID:28874461   PMID:29123029   PMID:29358217   PMID:29661841   PMID:29771991   PMID:30130256   PMID:30467111   PMID:30943054   PMID:31760770   PMID:32507043   PMID:32594804  
PMID:32619009   PMID:32830538   PMID:33480126   PMID:33525532   PMID:33789143   PMID:33993729   PMID:34262907   PMID:34319999   PMID:34338032   PMID:34549531   PMID:34576290   PMID:34603779  
PMID:34830315   PMID:34905510   PMID:35105870   PMID:35273307  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBImm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
T2T-CHM13v2.01203,418,967 - 203,430,485 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)Ensembl
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBI
ROS_Cfam_1.038740,693 - 762,325 (-)NCBI
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBI
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBI
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBI
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl964,809,146 - 64,822,636 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12525,159,816 - 25,193,620 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605525,943,204 - 25,954,169 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248076,817,195 - 6,827,462 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381133,350,256 - 133,350,435UniSTSGRCm38
MGSCv371135,246,833 - 135,247,012UniSTSGRCm37
Celera1176,970,004 - 176,970,183UniSTS
Celera1135,962,733 - 135,962,912UniSTS
Cytogenetic Map1E4UniSTS
cM Map1654.0UniSTS
cM Map1 UniSTS
Whitehead Genetic1640.4UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381133,355,183 - 133,355,292UniSTSGRCm38
MGSCv371135,251,760 - 135,251,869UniSTSGRCm37
Celera1176,974,912 - 176,975,021UniSTS
Celera1135,967,660 - 135,967,769UniSTS
Cytogenetic Map1E4UniSTS
cM Map170.0UniSTS
cM Map1 UniSTS
Whitehead Genetic173.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371135,252,051 - 135,252,165UniSTSGRCm37
Celera1135,967,951 - 135,968,065UniSTS
Celera1177,261,141 - 177,261,255UniSTS
Celera1176,975,202 - 176,975,316UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E4UniSTS
cM Map170.0UniSTS
cM Map1 UniSTS
Whitehead Genetic173.2UniSTS
Whitehead_YAC1 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371135,256,727 - 135,256,877UniSTSGRCm37
Celera1177,265,817 - 177,265,967UniSTS
Celera1176,979,894 - 176,980,044UniSTS
Celera1135,972,627 - 135,972,777UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
cM Map169.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371135,256,771 - 135,256,865UniSTSGRCm37
Celera1177,265,861 - 177,265,955UniSTS
Celera1176,979,938 - 176,980,032UniSTS
Celera1135,972,671 - 135,972,765UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
cM Map169.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371135,251,882 - 135,252,027UniSTSGRCm37
Celera1135,967,782 - 135,967,927UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
cM Map169.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381133,355,274 - 133,355,443UniSTSGRCm38
MGSCv371135,251,851 - 135,252,020UniSTSGRCm37
Celera1176,975,003 - 176,975,171UniSTS
Celera1135,967,751 - 135,967,920UniSTS
Cytogenetic Map1E4UniSTS
cM Map170.0UniSTS
Whitehead Genetic173.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381133,350,512 - 133,350,690UniSTSGRCm38
MGSCv371135,247,089 - 135,247,267UniSTSGRCm37
Celera1176,970,260 - 176,970,438UniSTS
Celera1135,962,989 - 135,963,167UniSTS
Cytogenetic Map1E4UniSTS
cM Map1654.0UniSTS
cM Map1 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381133,355,305 - 133,355,450UniSTSGRCm38
MGSCv371135,251,882 - 135,252,027UniSTSGRCm37
Celera1135,967,782 - 135,967,927UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381133,350,302 - 133,350,435UniSTSGRCm38
MGSCv371135,246,879 - 135,247,012UniSTSGRCm37
Celera1135,962,779 - 135,962,912UniSTS
Celera1176,970,050 - 176,970,183UniSTS
Cytogenetic Map1E4UniSTS
cM Map1654.0UniSTS
cM Map1 UniSTS
Whitehead Genetic1640.4UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
13524520Bodwtq1_mbody wweight QTL 1 (mouse)1131191160135621161Mouse
13513913Heal51_mwound healing/ regeneration 51 (mouse)1131780648135499606Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:316
Count of miRNA genes:246
Interacting mature miRNAs:265
Transcripts:ENSMUST00000094556, ENSMUST00000112287
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_031192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC034108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC068906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF117821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000094556   ⟹   ENSMUSP00000092135
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)Ensembl
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112287   ⟹   ENSMUSP00000107906
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1133,279,647 - 133,282,014 (+)Ensembl
GRCm38.p6 Ensembl1133,351,909 - 133,354,276 (+)Ensembl
RefSeq Acc Id: NM_031192   ⟹   NP_112469
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391133,278,412 - 133,288,058 (+)NCBI
GRCm381133,350,674 - 133,360,320 (+)ENTREZGENE
MGSCv371135,247,251 - 135,256,894 (+)RGD
Celera1135,963,151 - 135,972,797 (+)ENTREZGENE
Reference Sequences
RefSeq Acc Id: NP_112469   ⟸   NM_031192
- Peptide Label: precursor
- UniProtKB: P06281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107906   ⟸   ENSMUST00000112287
RefSeq Acc Id: ENSMUSP00000092135   ⟸   ENSMUST00000094556
Protein Domains
Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P06281-F1-model_v2 AlphaFold P06281 1-402 view protein structure  
Prorenin pdb 4amt P06281 22-402 view protein structure view video
Renin1 pdb 2x0b P06281 72-402 view protein structure view video

RGD ID:6874960
Promoter ID:EPDNEW_M931
Type:single initiation site
Description:Mus musculus renin 1 structural , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381133,350,676 - 133,350,736EPDNEW
RGD ID:6849874
Promoter ID:EP15035
Type:single initiation site
Description:Renin-1, REN1 or REN gene
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database,
Notes:homology_group=Homology group 81; Mammalian renin
Tissues & Cell Lines:kidney, submaxillary gland
Experiment Methods:Primer extension; Primer extension; transfected or transformed cells
Mouse AssemblyChrPosition (strand)Source
MGSCv371135,247,251 - 135,247,311EPD
MGSCv361135,247,251 - 135,247,311EPD

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97898 AgrOrtholog
Ensembl Genes ENSMUSG00000070645 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000092135 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000107906 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000094556 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000112287 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot
  Aspartic_peptidase_N UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot
  Renin-like_dom UniProtKB/Swiss-Prot
KEGG Report mmu:19701 UniProtKB/Swiss-Prot
PANTHER PTHR47966 UniProtKB/Swiss-Prot
Pfam A1_Propeptide UniProtKB/Swiss-Prot
  Asp UniProtKB/Swiss-Prot
PhenoGen Ren1 PhenoGen
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot
  RENI1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P97911 UniProtKB/Swiss-Prot
  Q543E5 UniProtKB/Swiss-Prot
  Q62153 UniProtKB/Swiss-Prot
  Q62154 UniProtKB/Swiss-Prot