Hey2 (hairy/enhancer-of-split related with YRPW motif 2) - Rat Genome Database

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Gene: Hey2 (hairy/enhancer-of-split related with YRPW motif 2) Mus musculus
Analyze
Symbol: Hey2
Name: hairy/enhancer-of-split related with YRPW motif 2
RGD ID: 1553745
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including circulatory system development; mesenchymal cell development; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; circulatory system development; and negative regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; nervous system; sensory organ; and tooth. Used to study aortic valve disease and tetralogy of Fallot. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bHLHb3; bHLHb32; CHF1; hairy and enhancer of split related 2; hairy and enhancer of split-related protein 2; Hairy-E(spl)-related with YRPW motif 2; hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif protein 2; Her; Herp1; Hes; HES-related repressor protein 2; HESR-2; hesr2; Hrt; HRT-2; Hrt2; mHRT2; protein gridlock homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,708,355 - 30,718,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)EnsemblGRCm39 Ensembl
GRCm381030,832,359 - 30,842,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,552,165 - 30,562,589 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,521,775 - 30,532,199 (-)NCBIMGSCv36mm8
Celera1031,757,027 - 31,767,443 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (IGI)
anterior/posterior pattern specification  (IBA)
aortic valve morphogenesis  (IDA)
arterial endothelial cell differentiation  (IGI)
artery development  (IGI)
ascending aorta morphogenesis  (IMP)
atrial septum morphogenesis  (IMP)
atrioventricular valve development  (IMP)
blood vessel development  (IGI)
blood vessel endothelial cell differentiation  (IGI)
cardiac epithelial to mesenchymal transition  (IMP)
cardiac left ventricle morphogenesis  (IMP)
cardiac muscle cell apoptotic process  (IMP)
cardiac muscle cell proliferation  (IMP)
cardiac muscle hypertrophy  (IMP)
cardiac muscle hypertrophy in response to stress  (IDA)
cardiac right ventricle morphogenesis  (IMP)
cardiac septum morphogenesis  (IMP)
cardiac vascular smooth muscle cell development  (IMP)
cardiac ventricle morphogenesis  (IMP)
cell fate commitment  (IMP)
circulatory system development  (IBA)
cochlea development  (IGI,IMP)
coronary vasculature morphogenesis  (IMP)
dorsal aorta morphogenesis  (IGI)
endocardial cushion to mesenchymal transition involved in heart valve formation  (IGI)
heart development  (ISO)
heart trabecula formation  (IMP)
labyrinthine layer blood vessel development  (IGI)
mesenchymal cell development  (IMP)
muscular septum morphogenesis  (IMP)
negative regulation of biomineral tissue development  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cardiac vascular smooth muscle cell differentiation  (ISO)
negative regulation of DNA-templated transcription  (IDA,IMP,ISO)
negative regulation of gene expression  (IMP)
negative regulation of Notch signaling pathway  (IDA,IMP)
negative regulation of smooth muscle cell differentiation  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
negative regulation of transcription initiation by RNA polymerase II  (ISO)
Notch signaling pathway  (IBA,IDA,IMP,ISO)
outflow tract morphogenesis  (IMP)
pattern specification process  (IGI,IMP)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of heart rate  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
protein-DNA complex assembly  (IDA)
pulmonary artery morphogenesis  (IMP)
pulmonary valve morphogenesis  (IMP)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IMP)
regulation of inner ear auditory receptor cell differentiation  (IGI)
regulation of neurogenesis  (IBA)
regulation of transcription by RNA polymerase II  (IBA,ISS)
regulation of vasculogenesis  (IGI)
tricuspid valve formation  (IMP)
tricuspid valve morphogenesis  (IMP)
umbilical cord morphogenesis  (IGI)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (IGI)
ventricular cardiac muscle cell development  (IMP)
ventricular septum morphogenesis  (IMP)
ventricular trabecula myocardium morphogenesis  (IGI)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic valve cusp morphology  (IAGP)
abnormal artery development  (IAGP)
abnormal artery morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cardinal vein morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal mitral valve morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary artery morphology  (IAGP)
abnormal pulmonary valve cusp morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal tricuspid valve morphology  (IAGP)
abnormal umbilical cord morphology  (IAGP)
abnormal ventricle myocardium morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal Z line morphology  (IAGP)
absent interventricular septum membranous part  (IAGP)
absent myocardial trabeculae  (IAGP)
aortic valve regurgitation  (IAGP)
aortic valve stenosis  (IAGP)
atrial septal defect  (IAGP)
atrioventricular valve regurgitation  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cardiomyopathy  (IAGP)
common atrium  (IAGP)
common ventricle  (IAGP)
congestive heart failure  (IAGP)
decreased angiogenesis  (IAGP)
decreased aorta wall thickness  (IAGP)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased heart rate  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated heart atrium  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IAGP)
heart left ventricle hypertrophy  (IAGP)
heart right ventricle hypertrophy  (IAGP)
hemorrhage  (IAGP)
incomplete somite formation  (IAGP)
increased heart weight  (IAGP)
increased lung weight  (IAGP)
increased response of heart to induced stress  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
liver vascular congestion  (IAGP)
mitral valve regurgitation  (IAGP)
muscular ventricular septal defect  (IAGP)
myocardial fiber disarray  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
ostium secundum atrial septal defect  (IAGP)
overriding aortic valve  (IAGP)
pale yolk sac  (IAGP)
patent cardiac foramen ovale  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary artery stenosis  (IAGP)
pulmonary edema  (IAGP)
pulmonary valve stenosis  (IAGP)
pulmonary vascular congestion  (IAGP)
respiratory distress  (IAGP)
small first pharyngeal arch  (IAGP)
small second pharyngeal arch  (IAGP)
thick aortic valve  (IAGP)
thick mitral valve cusps  (IAGP)
thick pulmonary valve  (IAGP)
thick semilunar valve  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
trabecula carnea hypoplasia  (IAGP)
tricuspid valve atresia  (IAGP)
tricuspid valve regurgitation  (IAGP)
tricuspid valve stenosis  (IAGP)
ventricular septal defect  (IAGP)
visceral vascular congestion  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. HERP1 is a cell type-specific primary target of Notch. Iso T, etal., J Biol Chem 2002 Feb 22;277(8):6598-607.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
12. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
Additional References at PubMed
PMID:10349636   PMID:10415358   PMID:10588864   PMID:10692439   PMID:10860664   PMID:10924525   PMID:10964718   PMID:11042159   PMID:11076679   PMID:11076861   PMID:11095750   PMID:11160397  
PMID:11217851   PMID:11486044   PMID:11486045   PMID:11572777   PMID:11641270   PMID:11784028   PMID:12372253   PMID:12372254   PMID:12454287   PMID:12477932   PMID:12947105   PMID:12971992  
PMID:14672936   PMID:14701881   PMID:14764602   PMID:15107403   PMID:15178686   PMID:15297376   PMID:15345511   PMID:15389319   PMID:15485867   PMID:15489334   PMID:15659488   PMID:15680351  
PMID:15689374   PMID:15821257   PMID:15901664   PMID:16000382   PMID:16025100   PMID:16061358   PMID:16141072   PMID:16141073   PMID:16199874   PMID:16242143   PMID:16337649   PMID:16554359  
PMID:16603706   PMID:16678147   PMID:16894625   PMID:17151600   PMID:17259303   PMID:17273555   PMID:17303760   PMID:17332425   PMID:17336907   PMID:17397913   PMID:17468400   PMID:17476283  
PMID:17576928   PMID:17685488   PMID:17709399   PMID:17948123   PMID:18239137   PMID:18287559   PMID:18291358   PMID:18297083   PMID:18302773   PMID:18545664   PMID:18557763   PMID:18579678  
PMID:18617694   PMID:18694942   PMID:18804439   PMID:19084512   PMID:19087347   PMID:19154718   PMID:19154719   PMID:19243017   PMID:19369401   PMID:19501159   PMID:19502490   PMID:19521566  
PMID:19631204   PMID:19644017   PMID:19666558   PMID:19703439   PMID:19723774   PMID:20001863   PMID:20007915   PMID:20017954   PMID:20059953   PMID:20346184   PMID:20382855   PMID:20568246  
PMID:20619341   PMID:20627076   PMID:20628571   PMID:20824138   PMID:20890042   PMID:20947685   PMID:21068310   PMID:21084383   PMID:21122108   PMID:21205794   PMID:21252157   PMID:21259317  
PMID:21267068   PMID:21290414   PMID:21300049   PMID:21311046   PMID:21349854   PMID:21402699   PMID:21420948   PMID:21606200   PMID:21632926   PMID:21633169   PMID:21677750   PMID:21779394  
PMID:21781958   PMID:21791528   PMID:21793101   PMID:21839733   PMID:21873635   PMID:21930795   PMID:21983003   PMID:21989910   PMID:22069191   PMID:22079635   PMID:22110751   PMID:22312437  
PMID:22331706   PMID:22408025   PMID:22536403   PMID:22615585   PMID:22639370   PMID:22652674   PMID:22675208   PMID:22711842   PMID:22783020   PMID:22865640   PMID:23123965   PMID:23199335  
PMID:23213461   PMID:23288164   PMID:23314057   PMID:23526992   PMID:23555309   PMID:23560082   PMID:23571217   PMID:23585229   PMID:23661717   PMID:23725765   PMID:23761906   PMID:23782701  
PMID:23830865   PMID:23872634   PMID:23946445   PMID:24019535   PMID:24145799   PMID:24167636   PMID:24337118   PMID:24391519   PMID:24465223   PMID:24552588   PMID:24583262   PMID:24673559  
PMID:24687990   PMID:24755984   PMID:24890415   PMID:24952961   PMID:25232121   PMID:25264302   PMID:25336743   PMID:25446183   PMID:25497097   PMID:25535917   PMID:25546423   PMID:25691540  
PMID:25715395   PMID:25733872   PMID:25848000   PMID:26209882   PMID:26450967   PMID:26552887   PMID:26553930   PMID:26577899   PMID:26598619   PMID:26641715   PMID:26791579   PMID:26856890  
PMID:27052172   PMID:27166947   PMID:27294512   PMID:27348588   PMID:27606604   PMID:27922003   PMID:28526753   PMID:28538179   PMID:28637782   PMID:28694461   PMID:28729659   PMID:28732025  
PMID:28893950   PMID:29016838   PMID:29107558   PMID:29155305   PMID:29371594   PMID:29409032   PMID:29422515   PMID:29444209   PMID:29540665   PMID:29743679   PMID:29853617   PMID:29891551  
PMID:30151366   PMID:30201295   PMID:30347193   PMID:30365070   PMID:30596653   PMID:30796970   PMID:30916783   PMID:31112136   PMID:31118233   PMID:31276493   PMID:31420575   PMID:31434798  
PMID:31591643   PMID:31676552   PMID:31789590   PMID:32035085   PMID:32112176   PMID:32857879   PMID:33410138   PMID:33454003   PMID:33730615   PMID:33773996   PMID:33898448   PMID:34189436  
PMID:34289385   PMID:34506481   PMID:34767447   PMID:34838591   PMID:34915728   PMID:35103284   PMID:35247391   PMID:35297995   PMID:35575074   PMID:35912776   PMID:36082581   PMID:36220812  
PMID:36239412   PMID:36325906   PMID:36685938   PMID:36971701   PMID:37042466   PMID:37254794   PMID:37324380   PMID:37385754   PMID:37649203   PMID:37669370   PMID:37702066   PMID:38374152  


Genomics

Comparative Map Data
Hey2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,708,355 - 30,718,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)EnsemblGRCm39 Ensembl
GRCm381030,832,359 - 30,842,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,552,165 - 30,562,589 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,521,775 - 30,532,199 (-)NCBIMGSCv36mm8
Celera1031,757,027 - 31,767,443 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.19NCBI
HEY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386125,749,632 - 125,761,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6125,747,664 - 125,761,269 (+)EnsemblGRCh38hg38GRCh38
GRCh376126,070,778 - 126,082,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,112,425 - 126,124,108 (+)NCBINCBI36Build 36hg18NCBI36
Build 346126,112,565 - 126,124,110NCBI
Celera6126,813,087 - 126,824,769 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6123,645,968 - 123,657,653 (+)NCBIHuRef
CHM1_16126,334,804 - 126,346,479 (+)NCBICHM1_1
T2T-CHM13v2.06126,938,147 - 126,949,784 (+)NCBIT2T-CHM13v2.0
Hey2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,641,100 - 28,651,187 (+)NCBIGRCr8
mRatBN7.2126,822,131 - 26,832,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,573,165 - 26,583,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0132,572,976 - 32,583,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,773,752 - 26,783,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,191,170 - 29,201,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,633,675 - 30,643,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,505,117 - 27,515,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,516,255 - 27,516,788 (+)NCBI
Celera125,500,527 - 25,510,614 (+)NCBICelera
Cytogenetic Map1p11NCBI
Hey2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
HEY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25145,733,083 - 145,744,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16143,638,233 - 143,649,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06123,527,180 - 123,538,794 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16127,647,547 - 127,659,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6127,647,547 - 127,659,056 (+)Ensemblpanpan1.1panPan2
HEY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1164,630,656 - 64,646,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha165,440,361 - 65,450,303 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0164,840,402 - 64,850,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl164,839,247 - 64,850,338 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1164,769,017 - 64,778,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0164,556,353 - 64,566,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,207,272 - 65,217,212 (+)NCBIUU_Cfam_GSD_1.0
Hey2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946114,704,470 - 114,715,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366393,703,447 - 3,716,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366393,705,225 - 3,714,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl137,219,883 - 37,231,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1137,219,887 - 37,231,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2140,989,466 - 41,000,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11347,965,808 - 47,977,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1347,964,847 - 47,977,346 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604020,275,597 - 20,288,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hey2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hey2
336 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:999
Count of miRNA genes:519
Interacting mature miRNAs:623
Transcripts:ENSMUST00000019924
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102689026446720483Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse

Markers in Region
Hey2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10A4UniSTS
cM Map1017.19UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019924   ⟹   ENSMUSP00000019924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)Ensembl
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1030,715,806 - 30,718,011 (-)Ensembl
GRCm38.p6 Ensembl1030,839,810 - 30,842,015 (-)Ensembl
RefSeq Acc Id: NM_013904   ⟹   NP_038932
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391030,708,355 - 30,718,779 (-)NCBI
GRCm381030,832,359 - 30,842,783 (-)ENTREZGENE
MGSCv371030,552,165 - 30,562,589 (-)RGD
Celera1031,757,027 - 31,767,443 (-)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_038932   ⟸   NM_013904
- UniProtKB: Q3TZ99 (UniProtKB/Swiss-Prot),   Q8CD44 (UniProtKB/Swiss-Prot),   Q9QUS4 (UniProtKB/Swiss-Prot),   Q0VGJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000019924   ⟸   ENSMUST00000019924
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUS4-F1-model_v2 AlphaFold Q9QUS4 1-339 view protein structure

Promoters
RGD ID:6846723
Promoter ID:MM_ACW:4278
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:HEY2.BSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361030,561,771 - 30,562,271 (-)MPROMDB
RGD ID:6819433
Promoter ID:MM_KWN:3845
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000019924
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361030,562,321 - 30,562,822 (-)MPROMDB
RGD ID:8671744
Promoter ID:EPDNEW_M13903
Type:initiation region
Name:Hey2_1
Description:Mus musculus hairy/enhancer-of-split related with YRPW motif2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381030,842,782 - 30,842,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341884 AgrOrtholog
Ensembl Genes ENSMUSG00000019789 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019924 ENTREZGENE
  ENSMUST00000019924.9 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15214 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1341884 ENTREZGENE
NCBI Gene 15214 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hey2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HEY2_MOUSE UniProtKB/Swiss-Prot
  Q0VGJ1 ENTREZGENE, UniProtKB/TrEMBL
  Q3TZ99 ENTREZGENE
  Q8CD44 ENTREZGENE
  Q9QUS4 ENTREZGENE
UniProt Secondary Q3TZ99 UniProtKB/Swiss-Prot
  Q8CD44 UniProtKB/Swiss-Prot