Hey2 (hes related family bHLH transcription factor with YRPW motif 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hey2 (hes related family bHLH transcription factor with YRPW motif 2) Chinchilla lanigera
Analyze
Symbol: Hey2
Name: hes related family bHLH transcription factor with YRPW motif 2
RGD ID: 8947327
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Brugada syndrome (ortholog); Carotid Artery Injuries (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2; hes-related family bHLH transcription factor with YRPW motif 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (ISO)
aortic valve morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
artery development  (ISO)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular valve development  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell differentiation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell fate commitment  (ISO)
cochlea development  (ISO)
coronary vasculature morphogenesis  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion to mesenchymal transition involved in heart valve formation  (ISO)
heart development  (ISO)
heart trabecula formation  (ISO)
labyrinthine layer blood vessel development  (ISO)
mesenchymal cell development  (ISO)
muscular septum morphogenesis  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  (ISO)
negative regulation of transcription initiation by RNA polymerase II  (ISO)
negative regulation of transcription regulatory region DNA binding  (ISO)
Notch signaling pathway  (ISO)
outflow tract morphogenesis  (ISO)
pattern specification process  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein-DNA complex assembly  (ISO)
pulmonary artery morphogenesis  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of gene expression  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of vasculogenesis  (ISO)
tricuspid valve formation  (ISO)
tricuspid valve morphogenesis  (ISO)
umbilical cord morphogenesis  (ISO)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (ISO)
ventricular cardiac muscle cell development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Hey2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
HEY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386125,749,632 - 125,761,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6125,747,664 - 125,761,269 (+)EnsemblGRCh38hg38GRCh38
GRCh376126,070,778 - 126,082,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,112,425 - 126,124,108 (+)NCBINCBI36hg18NCBI36
Build 346126,112,565 - 126,124,110NCBI
Celera6126,813,087 - 126,824,769 (+)NCBI
Cytogenetic Map6q22.31NCBI
HuRef6123,645,968 - 123,657,653 (+)NCBIHuRef
CHM1_16126,334,804 - 126,346,479 (+)NCBICHM1_1
T2T-CHM13v2.06126,938,147 - 126,949,784 (+)NCBI
Hey2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,708,355 - 30,718,779 (-)NCBIGRCm39mm39
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)Ensembl
GRCm381030,832,359 - 30,842,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,552,165 - 30,562,589 (-)NCBIGRCm37mm9NCBIm37
MGSCv361030,521,775 - 30,532,199 (-)NCBImm8
Celera1031,757,027 - 31,767,443 (-)NCBICelera
Cytogenetic Map10A4NCBI
Hey2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2126,822,131 - 26,832,218 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)Ensembl
Rnor_6.0129,191,170 - 29,201,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,633,675 - 30,643,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,505,117 - 27,515,204 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1127,516,255 - 27,516,788 (+)NCBI
Celera125,500,527 - 25,510,614 (+)NCBICelera
Cytogenetic Map1p11NCBI
HEY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16127,647,547 - 127,659,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6127,647,547 - 127,659,056 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06123,527,180 - 123,538,794 (+)NCBIMhudiblu_PPA_v0panPan3
HEY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1164,630,656 - 64,646,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha165,440,361 - 65,450,303 (+)NCBI
ROS_Cfam_1.0164,840,402 - 64,850,338 (+)NCBI
ROS_Cfam_1.0 Ensembl164,839,247 - 64,850,338 (+)Ensembl
UMICH_Zoey_3.1164,769,017 - 64,778,950 (+)NCBI
UNSW_CanFamBas_1.0164,556,353 - 64,566,279 (+)NCBI
UU_Cfam_GSD_1.0165,207,272 - 65,217,212 (+)NCBI
Hey2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946114,704,470 - 114,715,205 (+)NCBI
SpeTri2.0NW_0049366393,705,225 - 3,714,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl137,219,883 - 37,231,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1137,219,887 - 37,231,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2140,989,466 - 41,000,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11347,965,808 - 47,977,435 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1347,964,847 - 47,977,346 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604020,275,597 - 20,288,250 (-)NCBIVero_WHO_p1.0
Hey2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017360   ⟹   ENSCLAP00000017191
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)Ensembl
RefSeq Acc Id: XM_013516704   ⟹   XP_013372158
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013372158 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013372158   ⟸   XM_013516704
- Sequence:
RefSeq Acc Id: ENSCLAP00000017191   ⟸   ENSCLAT00000017360
Protein Domains
bHLH   Orange


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000017191 ENTREZGENE
  ENSCLAP00000017191.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017360 ENTREZGENE
  ENSCLAT00000017360.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
NCBI Gene Hey2 ENTREZGENE
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A8C2VTA1_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Hey2  hes related family bHLH transcription factor with YRPW motif 2    hes-related family bHLH transcription factor with YRPW motif 2  Symbol and/or name change 5135510 APPROVED
2015-08-25 Hey2  hes-related family bHLH transcription factor with YRPW motif 2    hairy/enhancer-of-split related with YRPW motif 2  Symbol and/or name change 5135510 APPROVED