Hey2 (hes related family bHLH transcription factor with YRPW motif 2) - Rat Genome Database

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Gene: Hey2 (hes related family bHLH transcription factor with YRPW motif 2) Chinchilla lanigera
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Symbol: Hey2
Name: hes related family bHLH transcription factor with YRPW motif 2
RGD ID: 8947327
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH aortic valve disease (ortholog); Breast Neoplasms (ortholog); Brugada syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2; hes-related family bHLH transcription factor with YRPW motif 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2ChinchillaCarotid Artery Injuries  ISOHey2 (Rattus norvegicus)9068941 RGDPMID:11971902 and REF_RGD_ID:625426
Hey2Chinchilladiabetic retinopathy  ISOHey2 (Mus musculus)9068941mRNA:increased expression:retina:RGDPMID:30787185 and REF_RGD_ID:155663348
Hey2Chinchillahemangiopericytoma  ISOHEY2 (Homo sapiens)9068941mRNA:increased expression:anterior temporal lobeRGDPMID:26951238 and REF_RGD_ID:155663351
Hey2Chinchillavaricose veins  ISOHEY2 (Homo sapiens)9068941mRNA more ...RGDPMID:26808710 and REF_RGD_ID:11529441
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2ChinchillaBreast Neoplasms  ISOHEY2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21036696
Hey2ChinchillaBrugada syndrome  ISOHEY2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23872634
Hey2Chinchillahypertrophic cardiomyopathy  ISOHEY2 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:20001863
Hey2Chinchillamalignant astrocytoma  ISOHEY2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21127729
Hey2Chinchillapancreatic ductal carcinoma  ISOHEY2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19208345
Hey2Chinchillaureteral obstruction  ISOHEY2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28318631
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2Chinchillaaortic valve disease  ISOHey2 (Mus musculus)9068941 MouseDO 
Hey2Chinchillatetralogy of Fallot  ISOHey2 (Mus musculus)9068941OMIM:187500MouseDO 


Biological Process
1 to 20 of 73 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2Chinchillaanterior/posterior axis specification acts_upstream_of_or_withinISOMGI:13418009068941 PMID:15680351MGIPMID:15680351
Hey2Chinchillaaortic valve morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:22110751BHF-UCLPMID:22110751
Hey2Chinchillaarterial endothelial cell differentiation involved_inISOUniProtKB:Q9WV939068941 PMID:15107403BHF-UCLPMID:15107403
Hey2Chinchillaartery development acts_upstream_of_or_withinISOMGI:13418009068941 PMID:15680351MGIPMID:15680351
Hey2Chinchillaascending aorta morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:12372254BHF-UCLPMID:12372254
Hey2Chinchillaatrial septum morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:12372254BHF-UCLPMID:12372254
Hey2Chinchillaatrioventricular valve development acts_upstream_of_or_withinISOMGI:35743949068941 PMID:15297376MGIPMID:15297376
Hey2Chinchillablood vessel development acts_upstream_of_or_withinISOMGI:13418009068941 PMID:15680351MGIPMID:15680351
Hey2Chinchillablood vessel endothelial cell differentiation acts_upstream_of_or_withinISOMGI:13418009068941 PMID:15107403MGIPMID:15107403
Hey2Chinchillacardiac epithelial to mesenchymal transition involved_inISOHey2 (Mus musculus)9068941 PMID:17303760BHF-UCLPMID:17303760
Hey2Chinchillacardiac left ventricle morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:12372254BHF-UCLPMID:12372254
Hey2Chinchillacardiac muscle cell apoptotic process acts_upstream_ofISOMGI:24476209068941 PMID:20382855MGIPMID:20382855
Hey2Chinchillacardiac muscle cell proliferation acts_upstream_ofISOMGI:24476209068941 PMID:17332425MGIPMID:17332425
Hey2Chinchillacardiac muscle hypertrophy acts_upstream_of_or_withinISOMGI:24476209068941 PMID:20382855MGIPMID:20382855
Hey2Chinchillacardiac muscle hypertrophy in response to stress acts_upstream_of_or_withinISOHey2 (Mus musculus)9068941 PMID:16603706MGIPMID:16603706
Hey2Chinchillacardiac right ventricle morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:12372254BHF-UCLPMID:12372254
Hey2Chinchillacardiac septum morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:17259303BHF-UCLPMID:17259303
Hey2Chinchillacardiac vascular smooth muscle cell development acts_upstream_of_or_withinISOMGI:24476209068941 PMID:20619341MGIPMID:20619341
Hey2Chinchillacardiac ventricle morphogenesis involved_inISOHey2 (Mus musculus)9068941 PMID:16199874UniProtPMID:16199874
Hey2Chinchillacell fate commitment acts_upstream_of_or_withinISOHey2 (Mus musculus)9068941 PMID:19154718MGIPMID:19154718
1 to 20 of 73 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2Chinchillacytoplasm located_inISOHey2 (Mus musculus)9068941 PMID:21290414UniProtPMID:21290414
Hey2Chinchillanucleus located_inISOHey2 (Mus musculus)9068941 PMID:11095750 and PMID:21290414UniProtPMID:11095750 and PMID:21290414
Hey2Chinchillatranscription repressor complex part_ofISOHEY2 (Homo sapiens)9068941 PMID:11486045BHF-UCLPMID:11486045

Molecular Function
1 to 20 of 26 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2Chinchillacis-regulatory region sequence-specific DNA binding enablesISOHey2 (Mus musculus)9068941 PMID:18239137BHF-UCLPMID:18239137
Hey2ChinchillaDNA binding enablesISOHey2 (Mus musculus)9068941 PMID:11095750UniProtPMID:11095750
Hey2ChinchillaDNA-binding transcription factor activity enablesISOHEY2 (Homo sapiens)9068941 PMID:15485867UniProtPMID:15485867
Hey2ChinchillaDNA-binding transcription factor activity enablesISOHey2 (Mus musculus)9068941 PMID:15485867UniProtPMID:15485867
Hey2ChinchillaDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOHEY2 (Homo sapiens)9068941 PMID:21290414UniProtPMID:21290414
Hey2ChinchillaDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOHey2 (Mus musculus)9068941 PMID:16199874 and PMID:18239137UniProtPMID:16199874 and PMID:18239137
Hey2Chinchillahistone deacetylase binding enablesISOUniProtKB:Q96EB69068941 PMID:12535671BHF-UCLPMID:12535671
Hey2Chinchillaidentical protein binding enablesISOPR:Q9QUS49068941 PMID:11076679MGIPMID:11076679
Hey2Chinchillaprotein binding enablesISOUniProtKB:P43694 and UniProtKB:Q929089068941 PMID:16199874UniProtPMID:16199874
Hey2Chinchillaprotein binding enablesISOUniProtKB:Q9Y5J39068941 PMID:33961781 and PMID:34819669IntActPMID:33961781 and PMID:34819669
Hey2Chinchillaprotein binding enablesISOPR:P15806 and PR:Q607229068941 PMID:11076679MGIPMID:11076679
Hey2Chinchillaprotein binding enablesISOUniProtKB:Q046669068941 PMID:11486045BHF-UCLPMID:11486045
Hey2Chinchillaprotein binding enablesISOUniProtKB:P436949068941 PMID:15485867UniProtPMID:15485867
Hey2Chinchillaprotein binding enablesISOUniProtKB:A8MQ03 more ...9068941 PMID:32296183IntActPMID:32296183
Hey2Chinchillaprotein binding enablesISOUniProtKB:O75376 and UniProtKB:Q605209068941 PMID:11486045BHF-UCLPMID:11486045
Hey2Chinchillaprotein binding enablesISOUniProtKB:Q13077 and UniProtKB:Q930629068941 PMID:25416956IntActPMID:25416956
Hey2Chinchillaprotein binding enablesISOUniProtKB:Q9NQ879068941 PMID:21454491UniProtPMID:21454491
Hey2Chinchillaprotein binding enablesISOUniProtKB:Q9DBX79068941 PMID:21259317UniProtPMID:21259317
Hey2Chinchillaprotein binding enablesISOUniProtKB:P428589068941 PMID:23275563IntActPMID:23275563
Hey2Chinchillaprotein binding enablesISOUniProtKB:Q96EB69068941 PMID:12535671IntActPMID:12535671
1 to 20 of 26 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hey2ChinchillaNotch signaling pathway   ISOHey2 (Rattus norvegicus)9068941 RGDPMID:11741889 and REF_RGD_ID:70528
Hey2ChinchillaNotch signaling pathway   ISOHey2 (Mus musculus)9068941 RGDPMID:17586813 and REF_RGD_ID:5135539

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Hey2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
HEY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386125,749,632 - 125,761,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6125,747,664 - 125,761,269 (+)EnsemblGRCh38hg38GRCh38
GRCh376126,070,778 - 126,082,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,112,425 - 126,124,108 (+)NCBINCBI36Build 36hg18NCBI36
Build 346126,112,565 - 126,124,110NCBI
Celera6126,813,087 - 126,824,769 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6123,645,968 - 123,657,653 (+)NCBIHuRef
CHM1_16126,334,804 - 126,346,479 (+)NCBICHM1_1
T2T-CHM13v2.06126,938,147 - 126,949,784 (+)NCBIT2T-CHM13v2.0
Hey2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,708,355 - 30,718,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)EnsemblGRCm39 Ensembl
GRCm381030,832,359 - 30,842,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,552,165 - 30,562,589 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,521,775 - 30,532,199 (-)NCBIMGSCv36mm8
Celera1031,757,027 - 31,767,443 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.19NCBI
Hey2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,641,100 - 28,651,187 (+)NCBIGRCr8
mRatBN7.2126,822,131 - 26,832,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,573,165 - 26,583,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0132,572,976 - 32,583,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,773,752 - 26,783,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,191,170 - 29,201,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,633,675 - 30,643,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,505,117 - 27,515,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,516,255 - 27,516,788 (+)NCBI
Celera125,500,527 - 25,510,614 (+)NCBICelera
Cytogenetic Map1p11NCBI
HEY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25145,733,083 - 145,744,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16143,638,233 - 143,649,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06123,527,180 - 123,538,794 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16127,647,547 - 127,659,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6127,647,547 - 127,659,056 (+)Ensemblpanpan1.1panPan2
HEY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1164,630,656 - 64,646,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha165,440,361 - 65,450,303 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0164,840,402 - 64,850,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl164,839,247 - 64,850,338 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1164,769,017 - 64,778,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0164,556,353 - 64,566,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,207,272 - 65,217,212 (+)NCBIUU_Cfam_GSD_1.0
Hey2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946114,704,470 - 114,715,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366393,703,447 - 3,716,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366393,705,225 - 3,714,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl137,219,883 - 37,231,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1137,219,887 - 37,231,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2140,989,466 - 41,000,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11347,965,808 - 47,977,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1347,964,847 - 47,977,346 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604020,275,597 - 20,288,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hey2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000017360   ⟹   ENSCLAP00000017191
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)Ensembl
RefSeq Acc Id: XM_013516704   ⟹   XP_013372158
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBI
Sequence:
Protein RefSeqs XP_013372158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017191
  ENSCLAP00000017191.1
RefSeq Acc Id: XP_013372158   ⟸   XM_013516704
- Sequence:
Ensembl Acc Id: ENSCLAP00000017191   ⟸   ENSCLAT00000017360
bHLH   Orange



1 to 20 of 20 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000011802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017360 ENTREZGENE
  ENSCLAT00000017360.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HES_HEY UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
NCBI Gene Hey2 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/TrEMBL
  SSF47459 UniProtKB/TrEMBL
UniProt A0A8C2VTA1_CHILA UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Hey2  hes related family bHLH transcription factor with YRPW motif 2    hes-related family bHLH transcription factor with YRPW motif 2  Symbol and/or name change 5135510 APPROVED
2015-08-25 Hey2  hes-related family bHLH transcription factor with YRPW motif 2    hairy/enhancer-of-split related with YRPW motif 2  Symbol and/or name change 5135510 APPROVED