Hey2 (hes related family bHLH transcription factor with YRPW motif 2) - Rat Genome Database

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Gene: Hey2 (hes related family bHLH transcription factor with YRPW motif 2) Heterocephalus glaber
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Symbol: Hey2
Name: hes related family bHLH transcription factor with YRPW motif 2
RGD ID: 18908316
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); aortic valve morphogenesis (ortholog); arterial endothelial cell differentiation (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH aortic valve disease (ortholog); Breast Neoplasms (ortholog); Brugada syndrome (ortholog); FOUND IN cytoplasm (ortholog); transcription repressor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (ISO)
aortic valve morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
artery development  (ISO)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular valve development  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell differentiation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell fate commitment  (ISO)
cochlea development  (ISO)
coronary vasculature morphogenesis  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion to mesenchymal transition involved in heart valve formation  (ISO)
heart development  (ISO)
heart trabecula formation  (ISO)
labyrinthine layer blood vessel development  (ISO)
mesenchymal cell development  (ISO)
muscular septum morphogenesis  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cardiac vascular smooth muscle cell differentiation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of smooth muscle cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription initiation by RNA polymerase II  (ISO)
Notch signaling pathway  (ISO)
outflow tract morphogenesis  (ISO)
pattern specification process  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein-DNA complex assembly  (ISO)
pulmonary artery morphogenesis  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of vasculogenesis  (ISO)
tricuspid valve formation  (ISO)
tricuspid valve morphogenesis  (ISO)
umbilical cord morphogenesis  (ISO)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (ISO)
ventricular cardiac muscle cell development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hey2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HEY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386125,749,632 - 125,761,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6125,747,664 - 125,761,269 (+)EnsemblGRCh38hg38GRCh38
GRCh376126,070,778 - 126,082,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,112,425 - 126,124,108 (+)NCBINCBI36Build 36hg18NCBI36
Build 346126,112,565 - 126,124,110NCBI
Celera6126,813,087 - 126,824,769 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6123,645,968 - 123,657,653 (+)NCBIHuRef
CHM1_16126,334,804 - 126,346,479 (+)NCBICHM1_1
T2T-CHM13v2.06126,938,147 - 126,949,784 (+)NCBIT2T-CHM13v2.0
Hey2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,708,355 - 30,718,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)EnsemblGRCm39 Ensembl
GRCm381030,832,359 - 30,842,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,552,165 - 30,562,589 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,521,775 - 30,532,199 (-)NCBIMGSCv36mm8
Celera1031,757,027 - 31,767,443 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.19NCBI
Hey2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,641,100 - 28,651,187 (+)NCBIGRCr8
mRatBN7.2126,822,131 - 26,832,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,573,165 - 26,583,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0132,572,976 - 32,583,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,773,752 - 26,783,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,191,170 - 29,201,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,633,675 - 30,643,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,505,117 - 27,515,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,516,255 - 27,516,788 (+)NCBI
Celera125,500,527 - 25,510,614 (+)NCBICelera
Cytogenetic Map1p11NCBI
Hey2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
HEY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25145,733,083 - 145,744,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16143,638,233 - 143,649,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06123,527,180 - 123,538,794 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16127,647,547 - 127,659,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6127,647,547 - 127,659,056 (+)Ensemblpanpan1.1panPan2
HEY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1164,630,656 - 64,646,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha165,440,361 - 65,450,303 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0164,840,402 - 64,850,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl164,839,247 - 64,850,338 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1164,769,017 - 64,778,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0164,556,353 - 64,566,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,207,272 - 65,217,212 (+)NCBIUU_Cfam_GSD_1.0
Hey2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946114,704,470 - 114,715,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366393,703,447 - 3,716,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366393,705,225 - 3,714,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl137,219,883 - 37,231,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1137,219,887 - 37,231,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2140,989,466 - 41,000,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11347,965,808 - 47,977,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1347,964,847 - 47,977,346 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604020,275,597 - 20,288,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024176   ⟹   ENSHGLP00000023958
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)Ensembl
RefSeq Acc Id: XM_004845937   ⟹   XP_004845994
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBI
RefSeq Acc Id: XM_021259214   ⟹   XP_021114873
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624753375,163 - 394,399 (+)NCBI
RefSeq Acc Id: XM_021259215   ⟹   XP_021114874
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624753375,163 - 388,990 (+)NCBI
RefSeq Acc Id: XM_021259216   ⟹   XP_021114875
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624753375,163 - 388,990 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004845994 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114873 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114874 (Get FASTA)   NCBI Sequence Viewer  
  XP_021114875 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023958
RefSeq Acc Id: XP_004845994   ⟸   XM_004845937
- UniProtKB: A0AAX6T204 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114873   ⟸   XM_021259214
- UniProtKB: A0AAX6T204 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114874   ⟸   XM_021259215
- UniProtKB: A0AAX6T204 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114875   ⟸   XM_021259216
- UniProtKB: A0AAX6T204 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023958   ⟸   ENSHGLT00000024176


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017079 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024176 ENTREZGENE
NCBI Gene Hey2 ENTREZGENE
UniProt A0AAX6T204 ENTREZGENE, UniProtKB/TrEMBL