Ccn2 (cellular communication network factor 2) - Rat Genome Database

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Gene: Ccn2 (cellular communication network factor 2) Mus musculus
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Symbol: Ccn2
Name: cellular communication network factor 2
RGD ID: 731014
MGI Page MGI
Description: Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage development; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccn; CCN family member 2; cellular communication network factor 1; connective tissue growth factor; Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24); Ctgf; fibroblast inducible secreated protein; fibroblast inducible secreted protein; Fis; fisp-12; Fisp12; Hcs2; Hcs24; hypertrophic chondrocyte-specific gene product 24; hypertrophic chondrocyte-specific protein 24
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,471,340 - 24,474,581 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,471,340 - 24,474,581 (+)EnsemblGRCm39 Ensembl
GRCm381024,595,442 - 24,598,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,595,442 - 24,598,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv371024,315,248 - 24,318,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,284,923 - 24,288,096 (+)NCBIMGSCv36mm8
Celera1025,537,033 - 25,540,272 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (ISO)
(R)-linalyl acetate  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1,8-cineole  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-methoxyethanol  (ISO)
2-tert-butylhydroquinone  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetaldehyde  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (EXP)
andrographolide  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
bazedoxifene  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
Betanin  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bromobenzene  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
camostat  (ISO)
camphor  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
cefaloridine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP,ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
diiodine  (EXP)
dioxygen  (EXP,ISO)
diquat  (EXP)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fipronil  (ISO)
fisetin  (ISO)
folic acid  (EXP)
fomepizole  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
galactose  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
gypenoside LXXV  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (EXP,ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
idebenone  (ISO)
iloprost  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (EXP,ISO)
jaspamide  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
letrozole  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
limonin  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP)
LY294002  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoprolol  (EXP,ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (ISO)
N(5)-ethyl-L-glutamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-phosphocreatine  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nitrofen  (ISO)
NORCANTHARIDIN  (ISO)
NSC 23766  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
olaparib  (EXP)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphane  (ISO)
pioglitazone  (ISO)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (ISO)
potassium cyanide  (EXP)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
prostaglandin E2  (EXP)
puerarin  (EXP)
quercetin  (EXP,ISO)
ramipril  (ISO)
resveratrol  (ISO)
rofecoxib  (EXP)
rosmarinic acid  (ISO)
rotenone  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sabinene  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium tungstate  (ISO)
sorafenib  (EXP)
spathulenol  (ISO)
sphingosine 1-phosphate  (EXP,ISO)
spironolactone  (ISO)
stattic  (EXP,ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetramethylpyrazine  (EXP)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-ferulic acid  (EXP)
triadimefon  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vanillin  (ISO)
verteporfin  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin D  (EXP)
vorinostat  (ISO)
XMU-MP-1  (EXP,ISO)
Y-27632  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IDA,IMP)
calcium ion transmembrane import into cytosol  (ISO)
cartilage condensation  (IDA)
cell adhesion  (IBA)
cell migration  (IDA)
cell-matrix adhesion  (IDA)
cellular response to fatty acid  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-13  (ISO)
chondrocyte differentiation  (IDA)
chondrocyte proliferation  (IMP)
connective tissue development  (IMP)
DNA biosynthetic process  (IEA)
extracellular matrix constituent secretion  (ISO)
fibroblast growth factor receptor signaling pathway  (IDA)
integrin-mediated signaling pathway  (IDA)
intracellular signal transduction  (ISO)
lung development  (IMP,ISO)
microtubule depolymerization  (ISO)
negative regulation of gene expression  (IMP)
ossification  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of cell activation  (ISO)
positive regulation of cell differentiation  (IBA,IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of G0 to G1 transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
reactive oxygen species metabolic process  (IDA)
regulation of chondrocyte differentiation  (IMP)
response to amino acid  (ISO)
response to anoxia  (ISO)
response to estradiol  (ISO)
response to fatty acid  (ISO)
response to mineralocorticoid  (ISO)
response to peptide hormone  (ISO)
signal transduction  (IBA)
tissue homeostasis  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal appendicular skeleton morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cervical atlas morphology  (IAGP)
abnormal cholangiocyte morphology  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal eye development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal pharyngeal arch development  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory conducting tube morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
absent ethmoid bone  (IAGP)
bowed fibula  (IAGP)
bowed radius  (IAGP)
bowed tibia  (IAGP)
bowed ulna  (IAGP)
chondrodystrophy  (IAGP)
cleft secondary palate  (IAGP)
decreased angiogenesis  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased embryo size  (IAGP)
decreased lean body mass  (IAGP)
decreased lung weight  (IAGP)
decreased mesenchymal cell proliferation involved in lung development  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased trabecular bone thickness  (IAGP)
delayed endochondral bone ossification  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
domed cranium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
facial cleft  (IAGP)
failure of palatal shelf elevation  (IAGP)
increased liver weight  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
kinked tail  (IAGP)
lateral facial cleft  (IAGP)
liver fibrosis  (IAGP)
midline facial cleft  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pectus excavatum  (IAGP)
pulmonary hypoplasia  (IAGP)
respiratory failure  (IAGP)
short face  (IAGP)
short mandible  (IAGP)
short sternum  (IAGP)
short tail  (IAGP)
small alveolar lamellar bodies  (IAGP)
small ears  (IAGP)
small lung  (IAGP)
small lung saccule  (IAGP)
small thoracic cavity  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Ares-Carrasco S, etal., Am J Physiol Heart Circ Physiol. 2009 Oct 9.
2. Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Barbolina MV, etal., Int J Cancer. 2009 Aug 15;125(4):816-25.
3. Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-induced diabetic rats. Bui BV, etal., Exp Eye Res. 2009 Jun;88(6):1076-83. Epub 2009 Feb 7.
4. Gene profiling of left ventricle eccentric hypertrophy in aortic regurgitation in rats: rationale for targeting the beta-adrenergic and renin-angiotensin systems. Champetier S, etal., Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H669-77. Epub 2008 Dec 26.
5. miR-30a attenuates cardiac fibrosis in rats with myocardial infarction by inhibiting CTGF. Chen L, etal., Exp Ther Med. 2018 May;15(5):4318-4324. doi: 10.3892/etm.2018.5952. Epub 2018 Mar 13.
6. Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. Cortijo J, etal., Br J Pharmacol. 2009 Feb;156(3):534-44.
7. Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. Fedorczyk JM, etal., J Orthop Res. 2009 Sep 9.
8. Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth factor. Ihm SH, etal., Basic Res Cardiol. 2009 Oct 23.
9. Highly Purified Eicosapentaenoic Acid Ethyl Ester Prevents Development of Steatosis and Hepatic Fibrosis in Rats. Kajikawa S, etal., Dig Dis Sci. 2009 Oct 24.
10. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
11. Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. Kundi R, etal., Cardiovasc Res. 2009 Nov 1;84(2):326-35. Epub 2009 Jul 1.
12. XLF-III-43, a novel coumarin-aspirin compound, prevents diabetic nephropathy in rats via inhibiting advanced glycation end products. Li H, etal., Eur J Pharmacol. 2009 Nov 4.
13. Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Li X, etal., Exp Biol Med (Maywood). 2009 May;234(5):504-12. Epub 2009 Feb 20.
14. Role of connective tissue growth factor in experimental radiation nephropathy in rats. Liu DG and Wang TM, Chin Med J (Engl). 2008 Oct 5;121(19):1925-31.
15. Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats. Liu N, etal., Am J Physiol Renal Physiol. 2004 Oct;287(4):F612-20. Epub 2004 Jun 1.
16. Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats. Louhelainen M, etal., J Hypertens. 2009 Oct;27(10):2094-107.
17. Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Lubel JS, etal., Clin Sci (Lond). 2009 Sep 14;117(11):375-86.
18. Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. Luo GH, etal., Transplant Proc. 2008 Sep;40(7):2365-9.
19. Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney. Ma FY, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F177-85. Epub 2008 Nov 5.
20. Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration. McClain JA, etal., Neurosci Lett. 2009 Aug 21;460(1):27-31. Epub 2009 May 20.
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity. Morrison JP, etal., Toxicol Pathol. 2009;37(4):502-11. Epub 2009 Apr 24.
24. Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Nakanishi T, etal., Biochem Biophys Res Commun 2001 Mar 2;281(3):678-81.
25. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
26. Simvastatin attenuates experimental small airway remodelling in rats. Ou XM, etal., Respirology. 2009 Jul;14(5):734-45.
27. Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload. Panek AN, etal., PLoS One. 2009 Aug 25;4(8):e6743.
28. Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation. Pi L, etal., Hepatology. 2008 Mar;47(3):996-1004.
29. CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling. Pi L, etal., J Cell Commun Signal. 2023 Mar;17(1):137-150. doi: 10.1007/s12079-022-00713-y. Epub 2022 Dec 5.
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Irbesartan ameliorates diabetic nephropathy by reducing the expression of connective tissue growth factor and alpha-smooth-muscle actin in the tubulointerstitium of diabetic rats. Ren X, etal., Pharmacology. 2009;83(2):80-7. Epub 2008 Dec 9.
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Urinary connective tissue growth factor increases far earlier than histopathological damage and functional deterioration in early chronic renal allograft injury. Shi Y, etal., Scand J Urol Nephrol. 2009;43(5):390-9. doi: 10.3109/00365520903142244.
35. Gene expression in rat dermal papilla cells: analysis of 2529 ESTs. Sleeman MA, etal., Genomics 2000 Oct 15;69(2):214-24.
36. Zinc supplementation partially prevents renal pathological changes in diabetic rats. Tang Y, etal., J Nutr Biochem. 2009 Apr 13.
37. Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. Thomas M, etal., Synapse. 2009 Oct;63(10):881-94.
38. ADVERSE EFFECTS OF HIGH GLUCOSE AND FREE FATTY ACID ON CARDIOMYOCYTES ARE MEDIATED BY CONNECTIVE TISSUE GROWTH FACTOR. Wang XY, etal., Am J Physiol Cell Physiol. 2009 Jul 22.
39. Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms. Xi S, etal., Exp Mol Med. 2009 Aug 31;41(8):538-47.
40. Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development. Xu J, etal., J Cell Biochem 2000 Feb;77(1):103-15.
41. Effect of Corilagin on the miR-21/smad7/ERK signaling pathway in a schistosomiasis-induced hepatic fibrosis mouse model. Yang F, etal., Parasitol Int. 2016 Aug;65(4):308-15. doi: 10.1016/j.parint.2016.03.001. Epub 2016 Mar 2.
42. LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. Ying L, etal., J Cell Sci. 2009 May 1;122(Pt 9):1441-51. Epub 2009 Apr 14.
43. Increased connective tissue growth factor expression in a rat model of chronic heart allograft rejection. Yuan YC, etal., J Formos Med Assoc. 2009 Mar;108(3):240-6.
44. Transcriptional changes in right ventricular tissues are enriched in the outflow tract compared with the apex during chronic pulmonary embolism in rats. Zagorski J, etal., Physiol Genomics. 2009 Sep 9;39(1):61-71. Epub 2009 Jul 14.
Additional References at PubMed
PMID:1419914   PMID:1888698   PMID:2029337   PMID:7687569   PMID:9135077   PMID:9184077   PMID:9780329   PMID:10082563   PMID:10446209   PMID:10595311   PMID:11973313   PMID:12036876  
PMID:12112457   PMID:12297288   PMID:12441304   PMID:12477932   PMID:12571253   PMID:12712324   PMID:12736220   PMID:12763067   PMID:12842083   PMID:14633130   PMID:15256388   PMID:15305294  
PMID:15315937   PMID:15376321   PMID:15489334   PMID:15496414   PMID:15574513   PMID:15610731   PMID:15699040   PMID:15800063   PMID:15862142   PMID:15980944   PMID:15981023   PMID:16019426  
PMID:16141072   PMID:16186174   PMID:16343439   PMID:16380465   PMID:16602821   PMID:16611331   PMID:16710777   PMID:16767377   PMID:16769906   PMID:16889607   PMID:17111364   PMID:17164417  
PMID:17197570   PMID:17204263   PMID:17215322   PMID:17239853   PMID:17330803   PMID:17350707   PMID:17362910   PMID:17541935   PMID:17554073   PMID:17625227   PMID:17657819   PMID:17765657  
PMID:17804598   PMID:17846733   PMID:17875658   PMID:17890868   PMID:18067859   PMID:18075496   PMID:18089935   PMID:18095342   PMID:18201696   PMID:18213577   PMID:18215621   PMID:18245842  
PMID:18276598   PMID:18287562   PMID:18319604   PMID:18474939   PMID:18481203   PMID:18535099   PMID:18554416   PMID:18596209   PMID:18597638   PMID:18632843   PMID:18667463   PMID:18835464  
PMID:18840685   PMID:18927151   PMID:19004856   PMID:19008461   PMID:19038999   PMID:19096030   PMID:19111553   PMID:19131512   PMID:19194549   PMID:19255250   PMID:19276073   PMID:19332661  
PMID:19364818   PMID:19385047   PMID:19407155   PMID:19409883   PMID:19411759   PMID:19423687   PMID:19498055   PMID:19500499   PMID:19541844   PMID:19565505   PMID:19657322   PMID:19698122  
PMID:19730442   PMID:19766716   PMID:19817698   PMID:19959709   PMID:20018872   PMID:20019329   PMID:20053791   PMID:20080568   PMID:20133625   PMID:20213804   PMID:20235153   PMID:20333347  
PMID:20348416   PMID:20406330   PMID:20430035   PMID:20445055   PMID:20497571   PMID:20534727   PMID:20571031   PMID:20585662   PMID:20615956   PMID:20637190   PMID:20721934   PMID:20877562  
PMID:20936632   PMID:20946117   PMID:21121985   PMID:21186275   PMID:21239535   PMID:21267068   PMID:21382976   PMID:21454550   PMID:21491433   PMID:21533890   PMID:21602138   PMID:21654839  
PMID:21747166   PMID:21750040   PMID:21826667   PMID:21868453   PMID:21873635   PMID:21876171   PMID:21913214   PMID:21925146   PMID:21969300   PMID:21978691   PMID:22008794   PMID:22035642  
PMID:22043022   PMID:22095278   PMID:22321187   PMID:22363445   PMID:22407321   PMID:22421594   PMID:22532143   PMID:22542845   PMID:22563064   PMID:22573622   PMID:22611085   PMID:22749815  
PMID:22885106   PMID:22903314   PMID:22913183   PMID:22926930   PMID:22993071   PMID:23048035   PMID:23073844   PMID:23142580   PMID:23175628   PMID:23199377   PMID:23212098   PMID:23284892  
PMID:23287510   PMID:23322166   PMID:23322734   PMID:23375831   PMID:23401504   PMID:23414741   PMID:23452880   PMID:23525012   PMID:23530034   PMID:23555635   PMID:23564449   PMID:23571711  
PMID:23620511   PMID:23673415   PMID:23741006   PMID:23756156   PMID:23778361   PMID:23816882   PMID:23839921   PMID:23863479   PMID:23868935   PMID:23904456   PMID:23918385   PMID:23950936  
PMID:23951098   PMID:23983074   PMID:23985903   PMID:23993699   PMID:24006456   PMID:24043783   PMID:24082083   PMID:24115331   PMID:24122827   PMID:24152728   PMID:24155087   PMID:24161906  
PMID:24217924   PMID:24288211   PMID:24380865   PMID:24391734   PMID:24464932   PMID:24508728   PMID:24574231   PMID:24595293   PMID:24627144   PMID:24688123   PMID:24727816   PMID:24754049  
PMID:24792956   PMID:24874179   PMID:24880616   PMID:24882759   PMID:24887312   PMID:24910328   PMID:24927931   PMID:24952961   PMID:25027872   PMID:25108224   PMID:25203810   PMID:25457224  
PMID:25464947   PMID:25515659   PMID:25554597   PMID:25580742   PMID:25644104   PMID:25706271   PMID:25712640   PMID:25715398   PMID:25870108   PMID:25875176   PMID:25912685   PMID:25955164  
PMID:26033091   PMID:26168233   PMID:26171399   PMID:26257513   PMID:26305214   PMID:26364758   PMID:26371318   PMID:26378152   PMID:26392029   PMID:26395480   PMID:26410398   PMID:26440278  
PMID:26447680   PMID:26549358   PMID:26554857   PMID:26686381   PMID:26699479   PMID:26727548   PMID:26743816   PMID:26775556   PMID:26825658   PMID:26952977   PMID:26984259   PMID:26989177  
PMID:26991260   PMID:27019229   PMID:27046831   PMID:27117402   PMID:27126736   PMID:27131347   PMID:27179776   PMID:27249171   PMID:27249321   PMID:27292642   PMID:27358050   PMID:27381226  
PMID:27436052   PMID:27558559   PMID:27641493   PMID:27662798   PMID:27734361   PMID:27927603   PMID:27935475   PMID:28079129   PMID:28087714   PMID:28118982   PMID:28159809   PMID:28183733  
PMID:28191821   PMID:28202523   PMID:28207886   PMID:28248965   PMID:28287886   PMID:28323616   PMID:28331224   PMID:28370212   PMID:28460577   PMID:28545716   PMID:28562688   PMID:28684544  
PMID:28710437   PMID:28742024   PMID:28753062   PMID:28782260   PMID:28825193   PMID:28943241   PMID:29031500   PMID:29045729   PMID:29111856   PMID:29160908   PMID:29165602   PMID:29438518  
PMID:29535639   PMID:29575960   PMID:29602800   PMID:29683732   PMID:29750395   PMID:29860398   PMID:29885461   PMID:29967264   PMID:30037926   PMID:30040954   PMID:30128894   PMID:30216109  
PMID:30228991   PMID:30305289   PMID:30487608   PMID:30504829   PMID:30716392   PMID:30789911   PMID:30842729   PMID:30912742   PMID:31028279   PMID:31220272   PMID:31320136   PMID:31391582  
PMID:31466059   PMID:31486675   PMID:31575647   PMID:31610176   PMID:31666704   PMID:31669521   PMID:31747096   PMID:31773302   PMID:31845734   PMID:31990056   PMID:32032283   PMID:32041253  
PMID:32057145   PMID:32120837   PMID:32134425   PMID:32155439   PMID:32160552   PMID:32186512   PMID:32240712   PMID:32325033   PMID:32386544   PMID:32423907   PMID:32502964   PMID:32520726  
PMID:32558157   PMID:32616521   PMID:32664674   PMID:32780108   PMID:33048316   PMID:33060128   PMID:33065236   PMID:33135480   PMID:33179083   PMID:33186530   PMID:33195213   PMID:33470127  
PMID:33475929   PMID:33483469   PMID:33510165   PMID:33512643   PMID:33527355   PMID:33637728   PMID:33662577   PMID:33789083   PMID:33984529   PMID:34004146   PMID:34032634   PMID:34161768  
PMID:34193558   PMID:34267330   PMID:34321664   PMID:34321999   PMID:34376651   PMID:34387544   PMID:34432562   PMID:34590686   PMID:34595178   PMID:34702315   PMID:34999833   PMID:35008801  
PMID:35042954   PMID:35045313   PMID:35112129   PMID:35138869   PMID:35167946   PMID:35204752   PMID:35247391   PMID:35340430   PMID:35830813   PMID:35921911   PMID:35926331   PMID:35951005  
PMID:36008747   PMID:36078110   PMID:36139407   PMID:36209585   PMID:36283963   PMID:36347239   PMID:36362374   PMID:36370365   PMID:36435829   PMID:36499730   PMID:36518337   PMID:36524378  
PMID:36550293   PMID:36625347   PMID:37389924   PMID:37529833   PMID:37543677   PMID:37561632   PMID:37702066   PMID:37839992   PMID:37851709   PMID:37973852   PMID:38101395   PMID:38407509  
PMID:38816193   PMID:38871984   PMID:39217171  


Genomics

Comparative Map Data
Ccn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,471,340 - 24,474,581 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,471,340 - 24,474,581 (+)EnsemblGRCm39 Ensembl
GRCm381024,595,442 - 24,598,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,595,442 - 24,598,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv371024,315,248 - 24,318,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,284,923 - 24,288,096 (+)NCBIMGSCv36mm8
Celera1025,537,033 - 25,540,272 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.84NCBI
CCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,948,176 - 131,951,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,948,176 - 131,951,372 (-)EnsemblGRCh38hg38GRCh38
GRCh376132,269,316 - 132,272,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,311,009 - 132,314,211 (-)NCBINCBI36Build 36hg18NCBI36
Build 346132,311,017 - 132,314,147NCBI
Celera6133,016,448 - 133,019,647 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,844,775 - 129,847,974 (-)NCBIHuRef
CHM1_16132,533,071 - 132,536,270 (-)NCBICHM1_1
T2T-CHM13v2.06133,143,212 - 133,146,410 (-)NCBIT2T-CHM13v2.0
Ccn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,621,498 - 22,624,614 (-)NCBIGRCr8
mRatBN7.2120,802,199 - 20,805,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,802,199 - 20,805,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,578,855 - 20,581,971 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,578,869 - 26,581,985 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,778,746 - 20,781,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,851,657 - 21,854,773 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,851,660 - 21,854,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,331,544 - 23,334,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,327,099 - 21,330,215 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,328,460 - 21,331,568 (-)NCBI
Celera119,554,327 - 19,557,443 (-)NCBICelera
Cytogenetic Map1p12NCBI
Ccn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,522,944 - 12,526,480 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,523,602 - 12,526,986 (-)NCBIChiLan1.0ChiLan1.0
CCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,935,526 - 151,947,055 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,842,461 - 149,845,654 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,729,572 - 129,733,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,836,319 - 133,839,017 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,836,319 - 133,842,077 (-)Ensemblpanpan1.1panPan2
CCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,508,082 - 25,511,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,507,662 - 25,510,145 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,004,899 - 26,007,816 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,930,014 - 24,932,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,930,014 - 24,933,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,975,729 - 24,978,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,865,809 - 24,868,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,137,679 - 25,140,601 (-)NCBIUU_Cfam_GSD_1.0
Ccn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,263,340 - 120,266,574 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493656042,537 - 45,807 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493656042,561 - 45,748 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,674,394 - 31,677,691 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,674,398 - 31,677,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,134,660 - 35,137,098 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,613,838 - 41,617,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1341,613,798 - 41,617,651 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604013,786,737 - 13,789,973 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247536,023,069 - 6,024,833 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247536,022,033 - 6,024,866 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccn2
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1105
Count of miRNA genes:494
Interacting mature miRNAs:607
Transcripts:ENSMUST00000020171, ENSMUST00000129142, ENSMUST00000176228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301659Arrd2_mage-related retinal degeneration 2 (mouse)Not determined102028318526890391Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
M-04697  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381024,597,743 - 24,597,905UniSTSGRCm38
MGSCv371024,317,549 - 24,317,711UniSTSGRCm37
Celera1025,539,334 - 25,539,496UniSTS
Cytogenetic Map10A3-B1UniSTS
Whitehead/MRC_RH10277.49UniSTS
D10Mit86  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381024,598,163 - 24,598,316UniSTSGRCm38
MGSCv371024,317,969 - 24,318,122UniSTSGRCm37
Celera1025,539,754 - 25,539,901UniSTS
Cytogenetic Map10A3-B1UniSTS
cM Map1017.0UniSTS
Whitehead Genetic1012.0UniSTS
D10Mit86.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381024,597,987 - 24,598,140UniSTSGRCm38
MGSCv371024,317,793 - 24,317,946UniSTSGRCm37
Celera1025,539,578 - 25,539,731UniSTS
Cytogenetic Map10A3-B1UniSTS
cM Map1017.0UniSTS
cM Map10 UniSTS
Whitehead Genetic1012.0UniSTS
D10Mit86.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381024,598,309 - 24,598,449UniSTSGRCm38
MGSCv371024,318,115 - 24,318,255UniSTSGRCm37
Celera1025,539,894 - 25,540,038UniSTS
Cytogenetic Map10A3-B1UniSTS
cM Map1017.0UniSTS
cM Map10 UniSTS
Whitehead Genetic1012.0UniSTS
Ctgf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381024,597,611 - 24,598,159UniSTSGRCm38
Celera1025,539,202 - 25,539,750UniSTS
Cytogenetic Map10A3-B1UniSTS
cM Map1011.84UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB039094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ031485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ892143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ917383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB317714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ055589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ159336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF905227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M70641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M70642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020171   ⟹   ENSMUSP00000020171
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1024,471,340 - 24,474,576 (+)Ensembl
GRCm38.p6 Ensembl1024,595,442 - 24,598,678 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129142   ⟹   ENSMUSP00000135212
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1024,471,678 - 24,472,268 (+)Ensembl
GRCm38.p6 Ensembl1024,595,780 - 24,596,370 (+)Ensembl
Ensembl Acc Id: ENSMUST00000176228   ⟹   ENSMUSP00000135147
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1024,471,624 - 24,474,581 (+)Ensembl
GRCm38.p6 Ensembl1024,595,726 - 24,598,683 (+)Ensembl
RefSeq Acc Id: NM_010217   ⟹   NP_034347
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391024,471,340 - 24,474,581 (+)NCBI
GRCm381024,595,442 - 24,598,683 (+)ENTREZGENE
MGSCv371024,315,248 - 24,318,489 (+)RGD
Celera1025,537,033 - 25,540,272 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034347   ⟸   NM_010217
- Peptide Label: precursor
- UniProtKB: G5E830 (UniProtKB/Swiss-Prot),   Q922U0 (UniProtKB/Swiss-Prot),   P29268 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000020171   ⟸   ENSMUST00000020171
Ensembl Acc Id: ENSMUSP00000135212   ⟸   ENSMUST00000129142
Ensembl Acc Id: ENSMUSP00000135147   ⟸   ENSMUST00000176228
Protein Domains
CTCK   IGFBP N-terminal   TSP type-1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29268-F1-model_v2 AlphaFold P29268 1-348 view protein structure

Promoters
RGD ID:6819145
Promoter ID:MM_KWN:3766
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:OTTMUST00000047191,   OTTMUST00000047192,   UC007EQW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361024,315,381 - 24,315,881 (+)MPROMDB
RGD ID:8671668
Promoter ID:EPDNEW_M13864
Type:multiple initiation site
Name:Ctgf_1
Description:Mus musculus connective tissue growth factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381024,595,502 - 24,595,562EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95537 AgrOrtholog
Ensembl Genes ENSMUSG00000019997 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020171 ENTREZGENE
  ENSMUST00000020171.12 UniProtKB/Swiss-Prot
  ENSMUST00000129142.2 UniProtKB/TrEMBL
  ENSMUST00000176228.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.40.20 UniProtKB/TrEMBL
InterPro CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14219 UniProtKB/Swiss-Prot
MGD MGI:95537 ENTREZGENE
NCBI Gene 14219 ENTREZGENE
PANTHER CCN FAMILY MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNECTIVE TISSUE GROWTH FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/Swiss-Prot
  IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccn2 PhenoGen
PIRSF IGFBP_rP_CNN UniProtKB/Swiss-Prot
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00041 UniProtKB/Swiss-Prot
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CTGF_MOUSE UniProtKB/Swiss-Prot
  G5E830 ENTREZGENE
  H3BJW0_MOUSE UniProtKB/TrEMBL
  H3BK14_MOUSE UniProtKB/TrEMBL
  P29268 ENTREZGENE
  Q922U0 ENTREZGENE
UniProt Secondary G5E830 UniProtKB/Swiss-Prot
  Q922U0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Ccn2  cellular communication network factor 2    cellular communication network factor 1  Symbol and/or name change 5135510 APPROVED
2018-11-13 Ccn2  cellular communication network factor 1  Ctgf  connective tissue growth factor  Symbol and/or name change 5135510 APPROVED