Tymp (thymidine phosphorylase) - Rat Genome Database

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Gene: Tymp (thymidine phosphorylase) Mus musculus
Symbol: Tymp
Name: thymidine phosphorylase
RGD ID: 1313980
Description: Enables thymidine phosphorylase activity. Involved in dTMP catabolic process. Predicted to be active in cytosol. Is expressed in alimentary system; axial skeleton; central nervous system; hindlimb; and retina. Used to study mitochondrial DNA depletion syndrome 1. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900072D10Rik; Ecgf1; endothelial cell growth factor 1 (platelet-derived); gli; gliostatin; PD-ECG; PD-ECGF; PDECG; PDECGF; Pdgfe; Pdgfec; platelet derived growth factor, endothelial cell; tdRPase; TP
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Fob3_m  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391589,255,834 - 89,261,239 (-)NCBIGRCm39mm39
GRCm39 Ensembl1589,256,134 - 89,261,242 (-)Ensembl
GRCm381589,371,631 - 89,377,036 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,371,931 - 89,377,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv371589,202,362 - 89,207,467 (-)NCBIGRCm37mm9NCBIm37
MGSCv361589,199,698 - 89,204,803 (-)NCBImm8
Celera1591,501,072 - 91,506,177 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
2-deoxy-alpha-D-ribose 1-phosphate  (ISO)
2-deoxy-D-ribofuranose 1-phosphate  (ISO)
4'-epidoxorubicin  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (EXP)
bisphenol A  (ISO)
bleomycin A2  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dioxygen  (ISO)
doxifluridine  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fipronil  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gemcitabine  (ISO)
glyphosate  (ISO)
gossypol  (ISO)
hydrazine  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
nocodazole  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pemetrexed  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
rotenone  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dodecyl sulfate  (ISO)
stavudine  (ISO)
sulfasalazine  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
thioacetamide  (ISO)
thymidine  (ISO)
thymine  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zalcitabine  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)


References - curated
1. Aishima S, etal., Int J Surg Pathol. 2002 Jan;10(1):47-56.
2. Brown NS, etal., Br J Cancer. 2005 May 9;92(9):1696-701.
3. Engels K, etal., J Pathol. 1997 Aug;182(4):414-20.
4. Harino Y, etal., Int J Clin Oncol. 2008 Oct;13(5):452-7. Epub 2008 Oct 23.
5. Hong SP, etal., Hepatogastroenterology. 2009 Jul-Aug;56(93):1178-82.
6. Jones A, etal., BJU Int. 2000 Jul;86(1):80-6.
7. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Kubiak R, etal., Z Naturforsch C. 1999 Dec;54(12):1096-102.
9. Lu H, etal., Clin Cancer Res. 2009 Aug 15;15(16):5136-44. Epub 2009 Aug 11.
10. Marine JC, etal., Mamm Genome 1996 Jun;7(6):413-6.
11. Mazurek A, etal., Neoplasma. 2008;55(3):261-5.
12. MGD data from the GO Consortium
13. Miszczak-Zaborska E, etal., Gynecol Oncol. 2004 Jul;94(1):86-92.
14. Morimoto Y, etal., Gan To Kagaku Ryoho. 2004 Dec;31(13):2195-8.
15. Nakashima M, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1309-13.
16. Nishino I, etal., Science. 1999 Jan 29;283(5402):689-92.
17. Nonomura N, etal., Int J Clin Oncol. 2006 Aug;11(4):297-302.
18. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. OMIM Disease Annotation Pipeline
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import SMPDB annotations from SMPDB into RGD
22. Puglisi F, etal., Ann Oncol. 2008 Apr 25;.
23. RGD automated import pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Takayama T, etal., Jpn J Clin Oncol. 2006 Sep;36(9):564-9. Epub 2006 Jul 22.
27. Wada S, etal., BJU Int. 2003 Jan;91(1):105-8.
28. Yanagi Y, etal., Invest Ophthalmol Vis Sci. 2003 Feb;44(2):751-4.
29. Yu ZG, etal., Zhonghua Yi Xue Za Zhi. 2006 Jun 13;86(22):1558-63.
30. Zhao B, etal., Jpn J Cancer Res. 2000 Mar;91(3):331-6.
Additional References at PubMed
PMID:1354638   PMID:1386365   PMID:7588749   PMID:8157699   PMID:8463278   PMID:8621489   PMID:8889548   PMID:9271678   PMID:10229200   PMID:10335479   PMID:10349636   PMID:10719795  
PMID:11042159   PMID:11076861   PMID:12077348   PMID:12477932   PMID:14610273   PMID:14651853   PMID:14681479   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17681069  
PMID:18799693   PMID:19028666   PMID:20884872   PMID:21267068   PMID:21855639   PMID:21873635   PMID:24362886   PMID:25287063   PMID:25805644   PMID:28514652   PMID:32476180  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391589,255,834 - 89,261,239 (-)NCBIGRCm39mm39
GRCm39 Ensembl1589,256,134 - 89,261,242 (-)Ensembl
GRCm381589,371,631 - 89,377,036 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,371,931 - 89,377,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv371589,202,362 - 89,207,467 (-)NCBIGRCm37mm9NCBIm37
MGSCv361589,199,698 - 89,204,803 (-)NCBImm8
Celera1591,501,072 - 91,506,177 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.86NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2250,525,752 - 50,530,032 (-)EnsemblGRCh38hg38GRCh38
GRCh382250,525,752 - 50,530,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372250,964,181 - 50,968,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,311,047 - 49,315,321 (-)NCBINCBI36hg18NCBI36
Build 342249,254,324 - 49,258,599NCBI
Celera2234,840,208 - 34,844,541 (-)NCBI
Cytogenetic Map22q13.33ENTREZGENE
HuRef2233,855,199 - 33,859,532 (-)NCBIHuRef
CHM1_12250,922,918 - 50,927,220 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27120,438,768 - 120,444,088 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7120,438,125 - 120,447,429 (-)Ensembl
mRatBN7.2 Ensembl7120,438,770 - 120,443,874 (-)Ensembl
Rnor_6.07130,342,481 - 130,347,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,342,483 - 130,347,587 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,027,662 - 130,033,050 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,666,518 - 127,671,624 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17127,700,749 - 127,705,854 (-)NCBI
Celera7116,911,732 - 116,916,838 (-)NCBICelera
Cytogenetic Map7q34NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541333,505,446 - 33,508,748 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,505,424 - 33,509,095 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12249,883,129 - 49,886,996 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02230,772,088 - 30,776,618 (-)NCBIMhudiblu_PPA_v0panPan3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945315,033 - 319,093 (+)NCBI
SpeTri2.0NW_004936629315,609 - 320,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11932,997,337 - 33,001,558 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1932,997,304 - 33,001,215 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,341,070 - 92,345,265 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_004624752251,670 - 256,243 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381589,375,019 - 89,375,127UniSTSGRCm38
MGSCv371589,205,450 - 89,205,558UniSTSGRCm37
Celera1591,504,160 - 91,504,268UniSTS
Cytogenetic Map15F1UniSTS
cM Map1551.6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381589,372,063 - 89,372,248UniSTSGRCm38
MGSCv371589,202,494 - 89,202,679UniSTSGRCm37
Celera1591,501,204 - 91,501,389UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E3UniSTS
cM Map1551.6UniSTS
cM Map1549.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381589,376,605 - 89,377,240UniSTSGRCm38
MGSCv371589,207,036 - 89,207,671UniSTSGRCm37
Celera1591,505,746 - 91,506,381UniSTS
Cytogenetic Map15F1UniSTS
cM Map1551.6UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381589,372,585 - 89,372,817UniSTSGRCm38
MGSCv371589,203,016 - 89,203,248UniSTSGRCm37
Celera1591,501,726 - 91,501,958UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E3UniSTS
cM Map1549.9UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
cM Map1544.86UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155724515691245304Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567386497101386646Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156492762598927745Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155370000089700000Mouse
12738413Lfibq10_mliver fibrosis QTL 10 (mouse)158795788490043083Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585988005104043685Mouse
1558845Alprf_malcohol preference (mouse)Not determined158746507090390365Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580415753104043685Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155724515691245304Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156327970297279794Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579265530104043685Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156545237799456827Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78716903102993272Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585988005104043685Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156564117599641298Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined80011059104043685Mouse
14928306Manh79_mmandible shape 79 (mouse)1578949676104043685Mouse
1301472Pain1_mpain 1 (mouse)Not determined157544899790928982Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585988005104043685Mouse
1301764Chab4_mcholesterol absorption 4 (mouse)Not determined1586751919104043685Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82717593104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585993114104043685Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580987052104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578716903102993272Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580987052104043685Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1579000000104043685Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156170000095700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:229
Interacting mature miRNAs:260
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000023285   ⟹   ENSMUSP00000023285
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1589,256,134 - 89,261,242 (-)Ensembl
GRCm38.p6 Ensembl1589,371,931 - 89,377,039 (-)Ensembl
RefSeq Acc Id: NM_138302   ⟹   NP_612175
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391589,255,834 - 89,261,239 (-)NCBI
GRCm381589,371,631 - 89,377,036 (-)NCBI
MGSCv371589,202,362 - 89,207,467 (-)RGD
Celera1591,501,072 - 91,506,177 (-)RGD
Protein Sequences
Protein RefSeqs NP_612175 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB41208 (Get FASTA)   NCBI Sequence Viewer  
  EDL04346 (Get FASTA)   NCBI Sequence Viewer  
  Q99N42 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_612175   ⟸   NM_138302
- UniProtKB: Q99N42 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000023285   ⟸   ENSMUST00000023285

RGD ID:6826593
Promoter ID:MM_KWN:19426
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361589,207,431 - 89,207,931 (-)MPROMDB
RGD ID:8684728
Promoter ID:EPDNEW_M20395
Type:multiple initiation site
Description:Mus musculus thymidine phosphorylase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381589,377,079 - 89,377,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920212 AgrOrtholog
Ensembl Genes ENSMUSG00000022615 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000023285 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023285 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1030.10 UniProtKB/Swiss-Prot
  3.90.1170.30 UniProtKB/Swiss-Prot
InterPro Glycosyl_Trfase_fam3 UniProtKB/Swiss-Prot
  Glycosyl_Trfase_fam3_N_dom UniProtKB/Swiss-Prot
  Glycosyl_Trfase_fam3_N_dom)sf UniProtKB/Swiss-Prot
  Nuc_phospho_transferase UniProtKB/Swiss-Prot
  PYNP-like_C_sf UniProtKB/Swiss-Prot
  PYNP_C UniProtKB/Swiss-Prot
  Pyrmidine_PPas_bac/euk UniProtKB/Swiss-Prot
  Thymidine/pyrmidine_PPase UniProtKB/Swiss-Prot
KEGG Report mmu:72962 UniProtKB/Swiss-Prot
PANTHER PTHR10515 UniProtKB/Swiss-Prot
Pfam Glycos_trans_3N UniProtKB/Swiss-Prot
  Glycos_transf_3 UniProtKB/Swiss-Prot
  PYNP_C UniProtKB/Swiss-Prot
PhenoGen Tymp PhenoGen
PIRSF TP_PyNP UniProtKB/Swiss-Prot
SMART PYNP_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47648 UniProtKB/Swiss-Prot
  SSF52418 UniProtKB/Swiss-Prot
  SSF54680 UniProtKB/Swiss-Prot
TIGRFAMs Y_phosphoryl UniProtKB/Swiss-Prot
UniProt Q99N42 ENTREZGENE, UniProtKB/Swiss-Prot