Trpc6 (transient receptor potential cation channel, subfamily C, member 6) - Rat Genome Database

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Gene: Trpc6 (transient receptor potential cation channel, subfamily C, member 6) Mus musculus
Analyze
Symbol: Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
RGD ID: 732721
MGI Page MGI
Description: Enables store-operated calcium channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including genitourinary system; gut; limb; liver; and nervous system. Used to study focal segmental glomerulosclerosis 2. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6); PARTICIPATES IN endothelin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (+)-conocarpan; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV025995; calcium entry channel; LLHWJM002; LLHWJM003; LLHWJM004; mtr; mtrp6; short transient receptor potential channel 6; Tr; transient receptor protein 6; TRP-6; Trrp6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,543,868 - 8,680,753 (+)NCBIGRCm39mm39
GRCm39 Ensembl98,544,143 - 8,680,742 (+)Ensembl
GRCm3898,543,867 - 8,680,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,544,142 - 8,680,741 (+)EnsemblGRCm38mm10GRCm38
MGSCv3798,544,142 - 8,680,741 (+)NCBIGRCm37mm9NCBIm37
MGSCv3698,544,711 - 8,642,583 (+)NCBImm8
Celera95,924,518 - 6,060,945 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-conocarpan  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetylcholine  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP,ISO)
amiloride  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
barium(0)  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
caesium atom  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbachol  (EXP)
cefaloridine  (ISO)
chlordecone  (EXP)
chloroprene  (EXP)
Cuprizon  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
fasudil  (EXP,ISO)
flavonoids  (ISO)
flufenamic acid  (ISO)
furan  (ISO)
gadolinium atom  (EXP)
GDP-beta-S  (EXP)
geldanamycin  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
hydrogen peroxide  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
KT 5823  (ISO)
lanthanum atom  (EXP)
lead diacetate  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
ML-7  (EXP)
nickel atom  (ISO)
nitrofen  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
panobinostat  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
progesterone  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rubidium atom  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
salvianolic acid B  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
SKF-96365 hydrochloride  (EXP,ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
strontium atom  (EXP)
sulforaphane  (EXP)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
U-73122  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
Y-27632  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alessandri-Haber N, etal., J Neurosci. 2009 May 13;29(19):6217-28. doi: 10.1523/JNEUROSCI.0893-09.2009.
2. Du W, etal., J Clin Invest. 2010 Oct;120(10):3480-92. doi: 10.1172/JCI43165. Epub 2010 Sep 1.
3. Li H, etal., J Neurochem. 2012 Dec;123(6):1010-8. doi: 10.1111/jnc.12045. Epub 2012 Nov 1.
4. Lin Y, etal., J Mol Neurosci. 2013 Jul;50(3):504-13. doi: 10.1007/s12031-013-9977-8. Epub 2013 Feb 23.
5. Liu X, etal., J Thorac Cardiovasc Surg. 2013 Mar 24. pii: S0022-5223(13)00274-2. doi: 10.1016/j.jtcvs.2013.02.076.
6. Liu Y, etal., Am J Nephrol. 2010;31(1):36-44. doi: 10.1159/000254060. Epub 2009 Oct 30.
7. Luan J, etal., J Pharmacol Sci. 2012;119(2):167-76. Epub 2012 May 22.
8. Marshall-Gradisnik S, etal., J Int Med Res. 2016 Dec;44(6):1381-1394. doi: 10.1177/0300060516671622. Epub 2016 Nov 11.
9. MGD data from the GO Consortium
10. Mir S, etal., Nephrol Dial Transplant. 2012 Jan;27(1):205-9. doi: 10.1093/ndt/gfr202. Epub 2011 Apr 21.
11. Mita M, etal., Clin Exp Pharmacol Physiol. 2010 Jul;37(7):670-8. doi: 10.1111/j.1440-1681.2010.05373.x. Epub 2010 Mar 12.
12. Nijenhuis T, etal., Am J Pathol. 2011 Oct;179(4):1719-32. doi: 10.1016/j.ajpath.2011.06.033. Epub 2011 Aug 11.
13. Obeidova L, etal., Folia Biol (Praha). 2012;58(4):173-6.
14. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Reiser J, etal., Nat Genet. 2005 Jul;37(7):739-44. Epub 2005 May 27.
18. RGD automated import pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Sonneveld R, etal., Am J Pathol. 2013 Apr;182(4):1196-204. doi: 10.1016/j.ajpath.2012.12.011. Epub 2013 Feb 4.
22. Spires D, etal., Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1091-F1097. doi: 10.1152/ajprenal.00155.2018. Epub 2018 Jun 20.
23. Wang X, etal., Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5751-8. Epub 2010 Jun 16.
24. Winn MP, etal., Science. 2005 Jun 17;308(5729):1801-4. Epub 2005 May 5.
25. Xie J, etal., Nat Commun. 2012;3:1238. doi: 10.1038/ncomms2240.
26. Yu Y, etal., Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13861-6. Epub 2004 Sep 9.
27. Zhu X, etal., Cell 1996 May 31;85(5):661-71.
Additional References at PubMed
PMID:9368034   PMID:9722956   PMID:10050885   PMID:10349636   PMID:10998353   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11390792   PMID:12477932   PMID:14699131   PMID:14761972  
PMID:15194687   PMID:15336983   PMID:15926917   PMID:16055711   PMID:16141072   PMID:16141073   PMID:16460286   PMID:16602821   PMID:16857711   PMID:17142322   PMID:17217054   PMID:17360584  
PMID:17480026   PMID:17603544   PMID:18209485   PMID:18495872   PMID:18516035   PMID:18559891   PMID:18631347   PMID:18635261   PMID:18701065   PMID:18725458   PMID:18983454   PMID:18989690  
PMID:19094061   PMID:19322198   PMID:19546355   PMID:19549525   PMID:19662354   PMID:19674119   PMID:19834762   PMID:19932145   PMID:19961855   PMID:20177073   PMID:20351294   PMID:20448219  
PMID:20466028   PMID:20588188   PMID:20877463   PMID:20978238   PMID:21048399   PMID:21059368   PMID:21258036   PMID:21261756   PMID:21267068   PMID:21294865   PMID:21421818   PMID:21448286  
PMID:21491433   PMID:21546445   PMID:21768109   PMID:21799177   PMID:21873635   PMID:22027011   PMID:22031853   PMID:22051675   PMID:22155451   PMID:22157757   PMID:22176814   PMID:22206677  
PMID:22337127   PMID:22493444   PMID:22684555   PMID:22701654   PMID:22724068   PMID:23022034   PMID:23045603   PMID:23193081   PMID:23233529   PMID:23529130   PMID:23636057   PMID:23657570  
PMID:23800468   PMID:23814119   PMID:23832809   PMID:23856489   PMID:23948707   PMID:24074949   PMID:24144647   PMID:24161570   PMID:24194522   PMID:24194600   PMID:24449818   PMID:24453217  
PMID:24462772   PMID:24520961   PMID:24550112   PMID:24553432   PMID:24731445   PMID:24740790   PMID:24838176   PMID:24928352   PMID:24952961   PMID:25097230   PMID:25143325   PMID:25213992  
PMID:25347706   PMID:25393730   PMID:25471572   PMID:25521631   PMID:25673771   PMID:25801675   PMID:25844902   PMID:25896763   PMID:26193076   PMID:26239116   PMID:26363733   PMID:26392222  
PMID:26520460   PMID:26581893   PMID:26604306   PMID:26858457   PMID:26968768   PMID:27109610   PMID:27177420   PMID:27626380   PMID:27861908   PMID:27879271   PMID:27881772   PMID:27932059  
PMID:27960162   PMID:27979597   PMID:28105583   PMID:28526717   PMID:28636132   PMID:28646178   PMID:28790356   PMID:28835433   PMID:28849300   PMID:29187535   PMID:29373286   PMID:29752403  
PMID:29793963   PMID:29958896   PMID:30017393   PMID:30270038   PMID:30452936   PMID:30665571   PMID:30779919   PMID:30785766   PMID:30786075   PMID:30873821   PMID:31099508   PMID:31162976  
PMID:31266820   PMID:31818953   PMID:31887787   PMID:31950205   PMID:32140760   PMID:32321939   PMID:32325033   PMID:32350291   PMID:32412783   PMID:32414784   PMID:32779844   PMID:32931478  
PMID:33015191   PMID:33301562   PMID:33606151   PMID:33884443  


Genomics

Comparative Map Data
Trpc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,543,868 - 8,680,753 (+)NCBIGRCm39mm39
GRCm39 Ensembl98,544,143 - 8,680,742 (+)Ensembl
GRCm3898,543,867 - 8,680,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl98,544,142 - 8,680,741 (+)EnsemblGRCm38mm10GRCm38
MGSCv3798,544,142 - 8,680,741 (+)NCBIGRCm37mm9NCBIm37
MGSCv3698,544,711 - 8,642,583 (+)NCBImm8
Celera95,924,518 - 6,060,945 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
TRPC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11101,451,564 - 101,872,562 (-)EnsemblGRCh38hg38GRCh38
GRCh3811101,451,470 - 101,584,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711101,322,295 - 101,454,738 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611100,827,584 - 100,959,869 (-)NCBINCBI36hg18NCBI36
Build 3411100,827,582 - 100,959,869NCBI
Celera1198,491,501 - 98,623,915 (-)NCBI
Cytogenetic Map11q22.1NCBI
HuRef1197,256,362 - 97,388,472 (-)NCBIHuRef
CHM1_111101,205,451 - 101,337,498 (-)NCBICHM1_1
Trpc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.285,759,387 - 5,864,000 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl85,758,935 - 5,828,092 (+)Ensembl
Rnor_6.086,811,543 - 6,917,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,811,543 - 6,917,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,799,564 - 6,904,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.485,472,515 - 5,577,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.185,472,514 - 5,577,536 (+)NCBI
Celera87,300,179 - 7,404,007 (+)NCBICelera
Cytogenetic Map8q11NCBI
Trpc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554124,906,650 - 4,950,525 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554124,905,039 - 5,019,678 (-)NCBIChiLan1.0ChiLan1.0
TRPC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11199,918,382 - 100,051,110 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1199,919,410 - 100,050,685 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01196,414,498 - 96,551,670 (-)NCBIMhudiblu_PPA_v0panPan3
TRPC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,897,378 - 30,007,885 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,897,210 - 30,007,723 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,849,049 - 29,959,895 (+)NCBI
ROS_Cfam_1.0529,962,647 - 30,073,659 (+)NCBI
UMICH_Zoey_3.1530,016,217 - 30,126,413 (+)NCBI
UNSW_CanFamBas_1.0529,864,510 - 29,975,743 (+)NCBI
UU_Cfam_GSD_1.0530,042,168 - 30,153,079 (+)NCBI
Trpc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,253,510 - 85,362,868 (-)NCBI
SpeTri2.0NW_0049365516,173,588 - 6,282,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl932,332,769 - 32,439,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1932,332,768 - 32,439,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,257,623 - 36,364,097 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,828,546 - 92,970,224 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl192,829,253 - 92,885,086 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,920,602 - 33,049,610 (+)NCBIVero_WHO_p1.0
Trpc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248781,321,022 - 1,469,964 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
U49069  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3898,680,560 - 8,680,708UniSTSGRCm38
MGSCv3798,680,560 - 8,680,708UniSTSGRCm37
Celera96,060,764 - 6,060,912UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Whitehead/MRC_RH966.87UniSTS
px-50g7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map7B5UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map3B-DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map4C1UniSTS
Cytogenetic Map18CUniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map9A1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map74.0UniSTS
cM Map1718.88UniSTS
cM Map241.25UniSTS
cM Map727.0UniSTS
cM Map342.1UniSTS
cM Map275.0UniSTS
cM Map153.6UniSTS
cM Map91.0UniSTS
Trpc6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3898,655,275 - 8,656,580UniSTSGRCm38
MGSCv3798,655,275 - 8,656,580UniSTSGRCm37
Celera96,035,749 - 6,037,054UniSTS
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Trrp6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS
cM Map91.0UniSTS
Trpc6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902908Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130430544Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000022300000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:73
Interacting mature miRNAs:81
Transcripts:ENSMUST00000050433
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001282086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF057748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000050433   ⟹   ENSMUSP00000057965
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl98,544,143 - 8,680,742 (+)Ensembl
GRCm38.p6 Ensembl98,544,142 - 8,680,741 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214596   ⟹   ENSMUSP00000149686
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl98,544,244 - 8,680,731 (+)Ensembl
GRCm38.p6 Ensembl98,544,243 - 8,680,730 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217462   ⟹   ENSMUSP00000150193
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl98,544,197 - 8,628,583 (+)Ensembl
GRCm38.p6 Ensembl98,544,196 - 8,628,582 (+)Ensembl
RefSeq Acc Id: NM_001282086   ⟹   NP_001269015
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,544,143 - 8,680,742 (+)NCBI
GRCm3898,544,142 - 8,680,741 (+)NCBI
Celera95,924,518 - 6,060,945 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001282087   ⟹   NP_001269016
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,544,143 - 8,628,583 (+)NCBI
GRCm3898,544,142 - 8,628,582 (+)NCBI
Celera95,924,518 - 6,060,945 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013838   ⟹   NP_038866
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,544,143 - 8,680,742 (+)NCBI
GRCm3898,544,142 - 8,680,741 (+)NCBI
MGSCv3798,544,142 - 8,680,741 (+)RGD
Celera95,924,518 - 6,060,945 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509849   ⟹   XP_006509912
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,544,073 - 8,680,733 (+)NCBI
GRCm3898,544,070 - 8,680,732 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006509850   ⟹   XP_006509913
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,543,933 - 8,680,753 (+)NCBI
GRCm3898,543,931 - 8,680,752 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011242359   ⟹   XP_011240661
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,543,933 - 8,680,753 (+)NCBI
GRCm3898,543,931 - 8,680,752 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011242360   ⟹   XP_011240662
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3998,543,868 - 8,680,753 (+)NCBI
GRCm3898,543,867 - 8,680,675 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038866   ⟸   NM_013838
- Peptide Label: isoform 1
- UniProtKB: Q61143 (UniProtKB/Swiss-Prot),   Q3UZG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269015   ⟸   NM_001282086
- Peptide Label: isoform 2
- UniProtKB: Q3UZG1 (UniProtKB/TrEMBL),   Q6NV56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269016   ⟸   NM_001282087
- Peptide Label: isoform 3
- UniProtKB: Q6NV56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509913   ⟸   XM_006509850
- Peptide Label: isoform X1
- UniProtKB: Q61143 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509912   ⟸   XM_006509849
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011240661   ⟸   XM_011242359
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011240662   ⟸   XM_011242360
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000150193   ⟸   ENSMUST00000217462
RefSeq Acc Id: ENSMUSP00000057965   ⟸   ENSMUST00000050433
RefSeq Acc Id: ENSMUSP00000149686   ⟸   ENSMUST00000214596
Protein Domains
ANK_REP_REGION

Promoters
RGD ID:8668778
Promoter ID:EPDNEW_M12420
Type:initiation region
Name:Trpc6_1
Description:Mus musculus transient receptor potential cation channel, subfamilyC, member 6 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3898,544,212 - 8,544,272EPDNEW
RGD ID:6845282
Promoter ID:MM_KWN:56346
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000098989,   NM_013838,   UC009ODK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3698,544,321 - 8,544,821 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109523 AgrOrtholog
Ensembl Genes ENSMUSG00000031997 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000057965 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000149686 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000150193 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050433 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000214596 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000217462 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC6_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22068 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109523 ENTREZGENE
NCBI Gene 22068 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpc6 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3UZG1 ENTREZGENE, UniProtKB/TrEMBL
  Q61143 ENTREZGENE
  Q6NV56 ENTREZGENE, UniProtKB/TrEMBL
  TRPC6_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B9EIW2 UniProtKB/Swiss-Prot
  Q9Z2J1 UniProtKB/Swiss-Prot