Lyl1 (lymphoblastomic leukemia 1) - Rat Genome Database
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Gene: Lyl1 (lymphoblastomic leukemia 1) Mus musculus
Analyze
Symbol: Lyl1
Name: lymphoblastomic leukemia 1
RGD ID: 1552564
MGI Page MGI
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in B cell differentiation and definitive hemopoiesis. Predicted to localize to nucleus. Is expressed in brain; genitourinary system; heart; liver; and thymus primordium. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human LYL1 (LYL1 basic helix-loop-helix family member); INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHa; bHLHa18; Lyl; Lyl-1; lymphoblastic leukemia-derived sequence 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,428,051 - 85,432,876 (+)NCBIGRCm39mm39
GRCm38884,701,423 - 84,704,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,701,449 - 84,704,940 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,225,356 - 87,228,615 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,591,649 - 87,594,797 (+)NCBImm8
Celera889,001,525 - 89,004,783 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:2000219   PMID:3162254   PMID:9143490   PMID:9479488   PMID:10087299   PMID:10349636   PMID:10825203   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073  
PMID:16514064   PMID:17053063   PMID:17112790   PMID:17486074   PMID:18287559   PMID:18557763   PMID:19200805   PMID:20418284   PMID:20705338   PMID:20887958   PMID:21267068   PMID:21387538  
PMID:21420467   PMID:21873635   PMID:22772404   PMID:23926305   PMID:24532287   PMID:24952961   PMID:28065741   PMID:30185409   PMID:30700838   PMID:31300405  


Genomics

Comparative Map Data
Lyl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,428,051 - 85,432,876 (+)NCBIGRCm39mm39
GRCm38884,701,423 - 84,704,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,701,449 - 84,704,940 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,225,356 - 87,228,615 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,591,649 - 87,594,797 (+)NCBImm8
Celera889,001,525 - 89,004,783 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.02NCBI
LYL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,099,033 - 13,103,161 (-)EnsemblGRCh38hg38GRCh38
GRCh381913,099,033 - 13,102,858 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,208,002 - 13,213,974 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,070,847 - 13,074,681 (-)NCBINCBI36hg18NCBI36
Build 341913,070,847 - 13,074,681NCBI
Celera1913,100,251 - 13,104,085 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,782,481 - 12,786,613 (-)NCBIHuRef
CHM1_11913,210,856 - 13,214,988 (-)NCBICHM1_1
Lyl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,815,207 - 25,818,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,815,207 - 25,818,074 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,790,826 - 36,793,693 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,115,234 - 25,118,100 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,120,059 - 25,122,926 (-)NCBI
Celera1923,005,834 - 23,008,676 (-)NCBICelera
Cytogenetic Map19q11NCBI
Lyl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,121,808 - 32,124,730 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,121,808 - 32,124,730 (-)NCBIChiLan1.0ChiLan1.0
LYL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,404,544 - 13,415,231 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,407,596 - 13,409,309 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,660,548 - 12,664,513 (-)NCBIMhudiblu_PPA_v0panPan3
LYL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,109,358 - 49,113,911 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lyl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,135,253 - 2,140,849 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LYL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,952,519 - 65,955,017 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,950,608 - 65,956,423 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,314,840 - 66,320,282 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LYL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,778,634 - 11,785,474 (-)NCBI
ChlSab1.1 Ensembl611,780,766 - 11,782,618 (-)Ensembl
Lyl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901645,263 - 648,550 (-)NCBI

Position Markers
UniSTS:235948  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,704,227 - 84,704,461UniSTSGRCm38
MGSCv37887,228,126 - 87,228,360UniSTSGRCm37
Celera889,004,295 - 89,004,529UniSTS
Cytogenetic Map8C1-C2UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:152
Interacting mature miRNAs:173
Transcripts:ENSMUST00000037165
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037165   ⟹   ENSMUSP00000046010
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,701,544 - 84,704,716 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238338   ⟹   ENSMUSP00000158640
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,701,781 - 84,704,155 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238364   ⟹   ENSMUSP00000158840
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,701,449 - 84,702,943 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238562   ⟹   ENSMUSP00000158636
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,701,482 - 84,704,940 (+)Ensembl
RefSeq Acc Id: NM_008535   ⟹   NP_032561
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,428,086 - 85,431,345 (+)NCBI
GRCm38884,701,457 - 84,704,716 (+)NCBI
MGSCv37887,225,356 - 87,228,615 (+)RGD
Celera889,001,525 - 89,004,783 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530744   ⟹   XP_006530807
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,428,051 - 85,432,876 (+)NCBI
GRCm38884,701,423 - 84,704,716 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530745   ⟹   XP_006530808
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,428,052 - 85,432,876 (+)NCBI
GRCm38884,701,423 - 84,704,714 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032561   ⟸   NM_008535
- UniProtKB: P27792 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530808   ⟸   XM_006530745
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006530807   ⟸   XM_006530744
- Peptide Label: isoform X1
- UniProtKB: P27792 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158640   ⟸   ENSMUST00000238338
RefSeq Acc Id: ENSMUSP00000158840   ⟸   ENSMUST00000238364
RefSeq Acc Id: ENSMUSP00000158636   ⟸   ENSMUST00000238562
RefSeq Acc Id: ENSMUSP00000046010   ⟸   ENSMUST00000037165
Protein Domains
bHLH

Promoters
RGD ID:8667695
Promoter ID:EPDNEW_M11871
Type:initiation region
Name:Lyl1_1
Description:Mus musculus lymphoblastomic leukemia 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11872  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,701,464 - 84,701,524EPDNEW
RGD ID:8667681
Promoter ID:EPDNEW_M11872
Type:initiation region
Name:Lyl1_2
Description:Mus musculus lymphoblastomic leukemia 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11871  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,701,779 - 84,701,839EPDNEW
RGD ID:6843424
Promoter ID:MM_KWN:55087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008535
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,224,431 - 87,225,727 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96891 AgrOrtholog
Ensembl Genes ENSMUSG00000034041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000046010 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158636 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000158640 UniProtKB/TrEMBL
  ENSMUSP00000158840 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037165 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000238338 UniProtKB/TrEMBL
  ENSMUST00000238364 UniProtKB/TrEMBL
  ENSMUST00000238562 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17095 UniProtKB/Swiss-Prot
MGD MGI:96891 ENTREZGENE
NCBI Gene 17095 ENTREZGENE
PANTHER PTHR13864 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lyl1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.4925 ENTREZGENE
UniProt A0A571BE88_MOUSE UniProtKB/TrEMBL
  A0A571BFA2_MOUSE UniProtKB/TrEMBL
  A0A571BG04_MOUSE UniProtKB/TrEMBL
  LYL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4FK84 UniProtKB/Swiss-Prot
  Q8BPE2 UniProtKB/Swiss-Prot
  Q923F0 UniProtKB/Swiss-Prot