Lyl1 (lymphoblastomic leukemia 1)

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Gene: Lyl1 (lymphoblastomic leukemia 1) Mus musculus

Analyze

Symbol:

Lyl1

Name:

lymphoblastomic leukemia 1

RGD ID:

1552564

MGI Page

MGI

Description:

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in B cell differentiation and definitive hemopoiesis. Predicted to localize to nucleus. Is expressed in brain; genitourinary system; heart; liver; and thymus primordium. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human LYL1 (LYL1 basic helix-loop-helix family member); INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

bHLHa; bHLHa18; Lyl; Lyl-1; lymphoblastic leukemia-derived sequence 1

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,428,051 - 85,432,876 (+)	NCBI	GRCm39		mm39
GRCm38	8	84,701,423 - 84,704,716 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,701,449 - 84,704,940 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,225,356 - 87,228,615 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	87,591,649 - 87,594,797 (+)	NCBI			mm8
Celera	8	89,001,525 - 89,004,783 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.02	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

lymphoid leukemia (ISO)

Marshall-Smith syndrome (ISO)

myelodysplastic syndrome (ISO)

T-cell acute lymphoblastic leukemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

4,4'-diaminodiphenylmethane (EXP)

acetamide (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

buta-1,3-diene (EXP)

C60 fullerene (ISO)

cadmium dichloride (ISO)

choline (EXP)

cytarabine (ISO)

endosulfan (ISO)

folic acid (EXP)

furan (ISO)

L-methionine (EXP)

lipopolysaccharide (EXP)

nicotine (EXP)

paracetamol (EXP)

phenylephrine (ISO)

Soman (ISO)

sunitinib (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (IMP)

blood vessel maturation (ISO)

definitive hemopoiesis (IMP)

positive regulation of transcription, DNA-templated (ISO)

regulation of transcription by RNA polymerase II (IBA)

regulation of transcription, DNA-templated (ISO)

Cellular Component

nucleus (IEA)

Molecular Function

DNA binding (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal hematopoietic stem cell physiology (IAGP)

abnormal T cell differentiation (IAGP)

arrested B cell differentiation (IAGP)

decreased B cell number (IAGP)

decreased pro-B cell number (IAGP)

thrombocytopenia (IAGP)

References

References - curated


1.	Baer R Semin Cancer Biol 1993 Dec;4(6):341-7.
2.	Fletcher CF, etal., Cell 1996 Nov 15;87(4):607-17.
3.	Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5.	Kuo SS, etal., Oncogene 1991 Jun;6(6):961-8.
6.	Liu M, etal., Genomics 1999 Feb 1;55(3):296-305.
7.	MGD data from the GO Consortium
8.	Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
9.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10.	OMIM Disease Annotation Pipeline
11.	Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
12.	RGD automated import pipeline
13.	RGD automated import pipeline for gene-chemical interactions
14.	Terajima M, etal., J Biochem (Tokyo) 1994 Nov;116(5):1105-10.

Additional References at PubMed

PMID:2000219	PMID:3162254	PMID:9143490	PMID:9479488	PMID:10087299	PMID:10349636	PMID:10825203	PMID:11042159	PMID:11076861	PMID:12477932	PMID:16141072	PMID:16141073
PMID:16514064	PMID:17053063	PMID:17112790	PMID:17486074	PMID:18287559	PMID:18557763	PMID:19200805	PMID:20418284	PMID:20705338	PMID:20887958	PMID:21267068	PMID:21387538
PMID:21420467	PMID:21873635	PMID:22772404	PMID:23926305	PMID:24532287	PMID:24952961	PMID:28065741	PMID:30185409	PMID:30700838	PMID:31300405

Genomics

Comparative Map Data

Lyl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,428,051 - 85,432,876 (+)	NCBI	GRCm39		mm39
GRCm38	8	84,701,423 - 84,704,716 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,701,449 - 84,704,940 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,225,356 - 87,228,615 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	87,591,649 - 87,594,797 (+)	NCBI			mm8
Celera	8	89,001,525 - 89,004,783 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.02	NCBI

LYL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	13,099,033 - 13,103,161 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	13,099,033 - 13,102,858 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	13,208,002 - 13,213,974 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	13,070,847 - 13,074,681 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	13,070,847 - 13,074,681	NCBI
Celera	19	13,100,251 - 13,104,085 (-)	NCBI
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	12,782,481 - 12,786,613 (-)	NCBI		HuRef
CHM1_1	19	13,210,856 - 13,214,988 (-)	NCBI		CHM1_1

Lyl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	19	25,815,207 - 25,818,074 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	25,815,207 - 25,818,074 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	36,790,826 - 36,793,693 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	25,115,234 - 25,118,100 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	25,120,059 - 25,122,926 (-)	NCBI
Celera	19	23,005,834 - 23,008,676 (-)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

Lyl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	32,121,808 - 32,124,730 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	32,121,808 - 32,124,730 (-)	NCBI	ChiLan1.0	ChiLan1.0

LYL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	13,404,544 - 13,415,231 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	13,407,596 - 13,409,309 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	12,660,548 - 12,664,513 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LYL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,109,358 - 49,113,911 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Lyl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936659	2,135,253 - 2,140,849 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LYL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	65,952,519 - 65,955,017 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	65,950,608 - 65,956,423 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,314,840 - 66,320,282 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LYL1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	11,778,634 - 11,785,474 (-)	NCBI
ChlSab1.1 Ensembl	6	11,780,766 - 11,782,618 (-)	Ensembl

Lyl1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624901	645,263 - 648,550 (-)	NCBI

Position Markers

UniSTS:235948

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	84,704,227 - 84,704,461	UniSTS	GRCm38
MGSCv37	8	87,228,126 - 87,228,360	UniSTS	GRCm37
Celera	8	89,004,295 - 89,004,529	UniSTS
Cytogenetic Map	8	C1-C2	UniSTS
Cytogenetic Map	8	C3	UniSTS
cM Map	8	38.5	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301874	Hdlq16_m	HDL QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
1301099	Cbm2_m	cerebellum weight 2 (mouse)			Not determined		8	78518613	112518703	Mouse
1301808	Nhdlq1_m	non-HDL QTL 1 (mouse)			Not determined		8	75685348	109685497	Mouse
10755519	Wbc1_m	white blood cell count 1 (mouse)					8	81619151	115619151	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
12904012	Cfq10_m	conditioned fear QTL 10 (mouse)					8	80066775	89014359	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	71396181	105396393	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	54706614	88706763	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	51882191	85882191	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
1357470	Obq16_m	obesity QTL 16 (mouse)			Not determined		8	75685348	109685497	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4141395	Char2a_m	P. chabaudi malaria resistance QTL 2a (mouse)			Not determined			71136783	90202598	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	55545028	89545028	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71287817	123895615	Mouse
10412234	Nhdlq14_m	non-HDL QTL 14 (mouse)			Not determined		8	75685348	109685497	Mouse
1301581	Char2_m	P. chabaudi malaria resistance QTL 2 (mouse)			Not determined		8	79082178	113082403	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71287817	123895615	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71102903	105103009	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58201479	92201479	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54287817	88287993	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1300920	Pitm3_m	prion incubation time 3 (mouse)			Not determined		8	73202495	107202598	Mouse
1558890	Lith18_m	lithogenic gene 18 (mouse)			Not determined		8	75675517	109675623	Mouse
10755530	Wbc2_m	white blood cell count 2 (mouse)					8	81092664	115092664	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	73400000	126100000	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	187
Count of miRNA genes:	152
Interacting mature miRNAs:	173
Transcripts:	ENSMUST00000037165
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_008535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006530744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006530745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC145556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK076114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC005736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY235816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO044699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT010167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X55055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X57686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X57687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000037165 ⟹ ENSMUSP00000046010

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,701,544 - 84,704,716 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000238338 ⟹ ENSMUSP00000158640

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,701,781 - 84,704,155 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000238364 ⟹ ENSMUSP00000158840

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,701,449 - 84,702,943 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000238562 ⟹ ENSMUSP00000158636

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	84,701,482 - 84,704,940 (+)	Ensembl

RefSeq Acc Id:

NM_008535 ⟹ NP_032561

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	85,428,086 - 85,431,345 (+)	NCBI
GRCm38	8	84,701,457 - 84,704,716 (+)	NCBI
MGSCv37	8	87,225,356 - 87,228,615 (+)	RGD
Celera	8	89,001,525 - 89,004,783 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GGACATCAGAGGCAGCCTTGCCACCTTTCCCCTTTGCACACGTTTGGCGCTGGGCTCCTGAGGG
TTGGGGGGTCTTCCAGTGCTGTGGGAGCAGCAAACCCCGAAGGGTGACTAGCCGGGGTGGATCA
GGAGGTGCGCGCTCCGTGATCCCTGCCCGCTGGTTTCCTCCGGGGTCAGCATTGCTTCTTATCA
GCCGCGGCCAGGCAGCCAGACCCTTATCTGCACAGGCCCAGCATCCTCTGGCCTCTGCGCCAGC
GGGTAAGAGGGAGGAAGCCAGGCTGTCGGGGGCGGGGGAAAGGGCGGGTCGGTCCAGGAGCAGC
TCACTTTCTCTTGGAGGTACCCACCACGACGCCTCCGAAGCTACTCAGGCCCTCCGGAGCCCGG
GAGGTGGCGCAGCCCAGCTCTGAGGCCCAACGGGAGGGATTACCTGGAGCACACCGGCCGAACT
GGACAGTGGAAACTGTCTCCTGACCTGGACTGACAAACCTGACCACACAGCCGGGTTCTCCAAG
CTGTGGAAACTGCTACAGGGTTAGCATTCTATCCGTGGGGTCCATGTGCCCGCCCCAGGCCAGA
GCAGAGGTGGGTTCCGCCATGACTGAGAAAACTGAGATGGTATGTGCCTCCAGCCCAGCACCTG
CCCCTCCCTCTAAGCCGGCCTCACCTGGGCCCCTTTCTACAGAGGAGGTGGACCACCGAAACAC
GTGCACTCCCTGGTTGCCTCCCGGCGTGCCAGTGATAAACCTGGGACACACCAGGCCCATAGGG
GCAGCCATGCCCACCACAGAGCTCAGTGCCTTTCGGCCCTCCTTGCTGCAGCTAACTGCCTTGG
GAAGAGCTCCACCTACCCTGGCTGTACATTACCACCCTCACCCCTTCCTCAACAGTGTCTACAT
TGGGCCAGCAGGACCCTTCAGCATCTTCCCTAACAGCCGGCTGAAGCGCAGACCAAGCCATAGT
GAGCTGGACTTGGCTGACGGGCACCAACCCCAGAAGGTGGCTCGGCGAGTGTTCACCAACAGCC
GTGAGCGCTGGCGGCAGCAGCACGTTAACGGCGCCTTCGCAGAGCTCAGGAAGCTGCTGCCCAC
CCACCCGCCCGACCGGAAGCTGAGCAAGAACGAGGTGCTGCGCCTGGCCATGAAGTATATAGGC
TTCCTGGTGCGGCTGCTGCGAGACCAAACGGCTGTGCTGACCTCCGGCCCCAGCGCTCCCGGGT
CCCGCAAGCCACCTGCGCGCAGGGGCGTGGAGGGCAGCGCACGCTTCGGGGCCGGGCACAGAGT
AGAGGCTGCACGCTCACAGCCCGTGCTTCCTGGGGACTGTGATGGCGACCCCAATGGGTCAGTG
AGACCCATCAAGTTGGAGCAGACGTCCCTGAGTCCTGAGGTGCGGTGACCCAAGGCAGAGGCGC
CTCACCTGCTGTTCAGTGAACTCCCTGTAAAAGGATCTCAGGTCGCCCAGATGAGGAAACGCCC
TGTAGCTCTGGAAGGGTGACCGGCGACGCCAGGGATCCCCAGACTTTTAAGAAAAATCTCCCAC
AGGCTACTTGCAGTGGCTTTGCCAGTGTCCTCTTGCCAGGGCCGAGGCCAGAGAATCGACAAGG
CCAAGTAGCCATGGGATCCCAGAGGTCCTGAGGGAGGTAGGGAAGGGTCTGGAAGCCTCCGCGC
TTCTCATCGGCGCCCCCTGCTGGAGGCGGGAAGACCCTAGACAAGTGTGTGGGAGGACCTACCC
CATGAAGCCCAACTGGTTGCGCTTGATCCATGATCCTGTTAACCGCGACAACGAAGACTCAGGC
ACTCTTGCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006530744 ⟹ XP_006530807

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	85,428,051 - 85,432,876 (+)	NCBI
GRCm38	8	84,701,423 - 84,704,716 (+)	NCBI

Sequence:

show sequence

AGGGGGTGGGGTTCAAAGCTAGACCAACCTCAGAGGACATCAGAGGCAGCCTTGCCACCTTTCC
CCTTTGCACACGTTTGGCGCTGGGCTCCTGAGGGTTGGGGGGTCTTCCAGTGCTGTGGGAGCAG
CAAACCCCGAAGGGTGACTAGCCGGGGTGGATCAGGAGGTGCGCGCTCCGTGATCCCTGCCCGC
TGGTTTCCTCCGGGGTCAGCATTGCTTCTTATCAGCCGCGGCCAGGCAGCCAGACCCTTATCTG
CACAGGCCCAGCATCCTCTGGCCTCTGCGCCAGCGGGTACCCACCACGACGCCTCCGAAGCTAC
TCAGGCCCTCCGGAGCCCGGGAGGTGGCGCAGCCCAGCTCTGAGGCCCAACGGGAGGGATTACC
TGGAGCACACCGGCCGAACTGGACAGTGGAAACTGTCTCCTGACCTGGACTGACAAACCTGACC
ACACAGCCGGGTTCTCCAAGCTGTGGAAACTGCTACAGGGTTAGCATTCTATCCGTGGGGTCCA
TGTGCCCGCCCCAGGCCAGAGCAGAGGTGGGTTCCGCCATGACTGAGAAAACTGAGATGGTATG
TGCCTCCAGCCCAGCACCTGCCCCTCCCTCTAAGCCGGCCTCACCTGGGCCCCTTTCTACAGAG
GAGGTGGACCACCGAAACACGTGCACTCCCTGGTTGCCTCCCGGCGTGCCAGTGATAAACCTGG
GACACACCAGGCCCATAGGGGCAGCCATGCCCACCACAGAGCTCAGTGCCTTTCGGCCCTCCTT
GCTGCAGCTAACTGCCTTGGGAAGAGCTCCACCTACCCTGGCTGTACATTACCACCCTCACCCC
TTCCTCAACAGTGTCTACATTGGGCCAGCAGGACCCTTCAGCATCTTCCCTAACAGCCGGCTGA
AGCGCAGACCAAGCCATAGTGAGCTGGACTTGGCTGACGGGCACCAACCCCAGAAGGTGGCTCG
GCGAGTGTTCACCAACAGCCGTGAGCGCTGGCGGCAGCAGCACGTTAACGGCGCCTTCGCAGAG
CTCAGGAAGCTGCTGCCCACCCACCCGCCCGACCGGAAGCTGAGCAAGAACGAGGTGCTGCGCC
TGGCCATGAAGTATATAGGCTTCCTGGTGCGGCTGCTGCGAGACCAAACGGCTGTGCTGACCTC
CGGCCCCAGCGCTCCCGGGTCCCGCAAGCCACCTGCGCGCAGGGGCGTGGAGGGCAGCGCACGC
TTCGGGGCCGGGCACAGAGTAGAGGCTGCACGCTCACAGCCCGTGCTTCCTGGGGACTGTGATG
GCGACCCCAATGGGTCAGTGAGACCCATCAAGTTGGAGCAGACGTCCCTGAGTCCTGAGGTGCG
GTGACCCAAGGCAGAGGCGCCTCACCTGCTGTTCAGTGAACTCCCTGTAAAAGGATCTCAGGTC
GCCCAGATGAGGAAACGCCCTGTAGCTCTGGAAGGGTGACCGGCGACGCCAGGGATCCCCAGAC
TTTTAAGAAAAATCTCCCACAGGCTACTTGCAGTGGCTTTGCCAGTGTCCTCTTGCCAGGGCCG
AGGCCAGAGAATCGACAAGGCCAAGTAGCCATGGGATCCCAGAGGTCCTGAGGGAGGTAGGGAA
GGGTCTGGAAGCCTCCGCGCTTCTCATCGGCGCCCCCTGCTGGAGGCGGGAAGACCCTAGACAA
GTGTGTGGGAGGACCTACCCCATGAAGCCCAACTGGTTGCGCTTGATCCATGATCCTGTTAACC
GCGACAACGAAGACTCAGGCACTCTTGCA

hide sequence

RefSeq Acc Id:

XM_006530745 ⟹ XP_006530808

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	85,428,052 - 85,432,876 (+)	NCBI
GRCm38	8	84,701,423 - 84,704,714 (+)	NCBI

Sequence:

show sequence

AGGGGGTGGGGTTCAAAGCTAGACCAACCTCAGAGGACATCAGAGGCAGCCTTGCCACCTTTCC
CCTTTGCACACGTTTGGCGCTGGGCTCCTGAGGGTTGGGGGGTCTTCCAGTGCTGTGGGAGCAG
CAAACCCCGAAGGGTGACTAGCCGGGGTGGATCAGGAGGTGCGCGCTCCGTGATCCCTGCCCGC
TGGTTTCCTCCGGGGTCAGCATTGCTTCTTATCAGCCGCGGCCAGGCAGCCAGACCCTTATCTG
CACAGGCCCAGCATCCTCTGGCCTCTGCGCCAGCGGGTAAGAGGGAGGAAGCCAGGCTGTCGGG
GGCGGGGGAAAGGGCGGGTCGGTCCAGGAGCAGCTCACTTTCTCTTGGAGGTACCCACCACGAC
GCCTCCGAAGCTACTCAGGCCCTCCGGAGCCCGGGAGGTGGCGCAGCCCAGCTCTGAGGCCCAA
CGGGAGGGATTACCTGGAGCACACCGGCCGAACTGGACAGTGGAAACTGTCTCCTGACCTGGAC
TGACAAACCTGACCACACAGCCGGGTTCTCCAAGCTGTGGAAACTGCTACAGGGTTAGCATTCT
ATCCGTGGGGTCCATGTGCCCGCCCCAGGCCAGAGCAGAGAGGAGGTGGACCACCGAAACACGT
GCACTCCCTGGTTGCCTCCCGGCGTGCCAGTGATAAACCTGGGACACACCAGGCCCATAGGGGC
AGCCATGCCCACCACAGAGCTCAGTGCCTTTCGGCCCTCCTTGCTGCAGCTAACTGCCTTGGGA
AGAGCTCCACCTACCCTGGCTGTACATTACCACCCTCACCCCTTCCTCAACAGTGTCTACATTG
GGCCAGCAGGACCCTTCAGCATCTTCCCTAACAGCCGGCTGAAGCGCAGACCAAGCCATAGTGA
GCTGGACTTGGCTGACGGGCACCAACCCCAGAAGGTGGCTCGGCGAGTGTTCACCAACAGCCGT
GAGCGCTGGCGGCAGCAGCACGTTAACGGCGCCTTCGCAGAGCTCAGGAAGCTGCTGCCCACCC
ACCCGCCCGACCGGAAGCTGAGCAAGAACGAGGTGCTGCGCCTGGCCATGAAGTATATAGGCTT
CCTGGTGCGGCTGCTGCGAGACCAAACGGCTGTGCTGACCTCCGGCCCCAGCGCTCCCGGGTCC
CGCAAGCCACCTGCGCGCAGGGGCGTGGAGGGCAGCGCACGCTTCGGGGCCGGGCACAGAGTAG
AGGCTGCACGCTCACAGCCCGTGCTTCCTGGGGACTGTGATGGCGACCCCAATGGGTCAGTGAG
ACCCATCAAGTTGGAGCAGACGTCCCTGAGTCCTGAGGTGCGGTGACCCAAGGCAGAGGCGCCT
CACCTGCTGTTCAGTGAACTCCCTGTAAAAGGATCTCAGGTCGCCCAGATGAGGAAACGCCCTG
TAGCTCTGGAAGGGTGACCGGCGACGCCAGGGATCCCCAGACTTTTAAGAAAAATCTCCCACAG
GCTACTTGCAGTGGCTTTGCCAGTGTCCTCTTGCCAGGGCCGAGGCCAGAGAATCGACAAGGCC
AAGTAGCCATGGGATCCCAGAGGTCCTGAGGGAGGTAGGGAAGGGTCTGGAAGCCTCCGCGCTT
CTCATCGGCGCCCCCTGCTGGAGGCGGGAAGACCCTAGACAAGTGTGTGGGAGGACCTACCCCA
TGAAGCCCAACTGGTTGCGCTTGATCCATGATCCTGTTAACCGCGACAACGAAGACTCAGGCAC
TCTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_032561	(Get FASTA)	NCBI Sequence Viewer
	XP_006530807	(Get FASTA)	NCBI Sequence Viewer
	XP_006530808	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH05736	(Get FASTA)	NCBI Sequence Viewer
	BAC36194	(Get FASTA)	NCBI Sequence Viewer
	CAA38896	(Get FASTA)	NCBI Sequence Viewer
	CAA40870	(Get FASTA)	NCBI Sequence Viewer
	CAJ18375	(Get FASTA)	NCBI Sequence Viewer
	EDL10952	(Get FASTA)	NCBI Sequence Viewer
	EDL10953	(Get FASTA)	NCBI Sequence Viewer
	P27792	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_032561 ⟸ NM_008535

- UniProtKB:

P27792 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MCPPQARAEVGSAMTEKTEMVCASSPAPAPPSKPASPGPLSTEEVDHRNTCTPWLPPGVPVINL
GHTRPIGAAMPTTELSAFRPSLLQLTALGRAPPTLAVHYHPHPFLNSVYIGPAGPFSIFPNSRL
KRRPSHSELDLADGHQPQKVARRVFTNSRERWRQQHVNGAFAELRKLLPTHPPDRKLSKNEVLR
LAMKYIGFLVRLLRDQTAVLTSGPSAPGSRKPPARRGVEGSARFGAGHRVEAARSQPVLPGDCD
GDPNGSVRPIKLEQTSLSPEVR

hide sequence

RefSeq Acc Id:

XP_006530808 ⟸ XM_006530745

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPTTELSAFRPSLLQLTALGRAPPTLAVHYHPHPFLNSVYIGPAGPFSIFPNSRLKRRPSHSEL
DLADGHQPQKVARRVFTNSRERWRQQHVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYIGFL
VRLLRDQTAVLTSGPSAPGSRKPPARRGVEGSARFGAGHRVEAARSQPVLPGDCDGDPNGSVRP
IKLEQTSLSPEVR

hide sequence

RefSeq Acc Id:	XP_006530807 ⟸ XM_006530744
- Peptide Label:	isoform X1
- UniProtKB:	P27792 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MCPPQARAEVGSAMTEKTEMVCASSPAPAPPSKPASPGPLSTEEVDHRNTCTPWLPPGVPVINL GHTRPIGAAMPTTELSAFRPSLLQLTALGRAPPTLAVHYHPHPFLNSVYIGPAGPFSIFPNSRL KRRPSHSELDLADGHQPQKVARRVFTNSRERWRQQHVNGAFAELRKLLPTHPPDRKLSKNEVLR LAMKYIGFLVRLLRDQTAVLTSGPSAPGSRKPPARRGVEGSARFGAGHRVEAARSQPVLPGDCD GDPNGSVRPIKLEQTSLSPEVR hide sequence

RefSeq Acc Id:

ENSMUSP00000158640 ⟸ ENSMUST00000238338

RefSeq Acc Id:

ENSMUSP00000158840 ⟸ ENSMUST00000238364

RefSeq Acc Id:

ENSMUSP00000158636 ⟸ ENSMUST00000238562

RefSeq Acc Id:

ENSMUSP00000046010 ⟸ ENSMUST00000037165

Protein Domains

bHLH

Promoters

RGD ID:

8667695

Promoter ID:

EPDNEW_M11871

Type:

initiation region

Name:

Lyl1_1

Description:

Mus musculus lymphoblastomic leukemia 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11872

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	84,701,464 - 84,701,524	EPDNEW

RGD ID:

8667681

Promoter ID:

EPDNEW_M11872

Type:

initiation region

Name:

Lyl1_2

Description:

Mus musculus lymphoblastomic leukemia 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11871

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	84,701,779 - 84,701,839	EPDNEW

RGD ID:

6843424

Promoter ID:

MM_KWN:55087

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, Kidney, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_008535

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	87,224,431 - 87,225,727 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:96891	AgrOrtholog
Ensembl Genes	ENSMUSG00000034041	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000046010	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000158636	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUSP00000158640	UniProtKB/TrEMBL
	ENSMUSP00000158840	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000037165	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000238338	UniProtKB/TrEMBL
	ENSMUST00000238364	UniProtKB/TrEMBL
	ENSMUST00000238562	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TAL-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:17095	UniProtKB/Swiss-Prot
MGD	MGI:96891	ENTREZGENE
NCBI Gene	17095	ENTREZGENE
PANTHER	PTHR13864	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lyl1	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HLH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.4925	ENTREZGENE
UniProt	A0A571BE88_MOUSE	UniProtKB/TrEMBL
	A0A571BFA2_MOUSE	UniProtKB/TrEMBL
	A0A571BG04_MOUSE	UniProtKB/TrEMBL
	LYL1_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q4FK84	UniProtKB/Swiss-Prot
	Q8BPE2	UniProtKB/Swiss-Prot
	Q923F0	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM