Bdkrb2 (bradykinin receptor, beta 2) - Rat Genome Database

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Gene: Bdkrb2 (bradykinin receptor, beta 2) Mus musculus
Analyze
Symbol: Bdkrb2
Name: bradykinin receptor, beta 2
RGD ID: 10232
MGI Page MGI
Description: Predicted to enable several functions, including G protein-coupled receptor binding activity; bradykinin receptor activity; and protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; and vasodilation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Is expressed in metanephros; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B(2); B2; B2 bradykinin receptor; B2R; BK-2; BK-2 receptor; BK2; BK2R; BKR2; BRB2; kinin B2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,529,431 - 105,561,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,529,485 - 105,561,496 (+)EnsemblGRCm39 Ensembl
GRCm3812105,563,172 - 105,595,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,563,226 - 105,595,237 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,801,382 - 106,831,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,964,222 - 105,994,121 (+)NCBIMGSCv36mm8
Celera12106,797,782 - 106,827,683 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (EXP)
1,2-dichloroethane  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxycyclophosphamide  (ISO)
5-fluorouracil  (ISO)
6-oxoprostaglandin F1alpha  (EXP,ISO)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
amlodipine  (EXP)
aristolochic acid A  (ISO)
atenolol  (ISO)
atropine  (EXP)
benazepril  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (ISO)
capsaicin  (ISO)
captopril  (EXP)
carbon nanotube  (EXP)
ceruletide  (EXP)
CGP 52608  (ISO)
chondroitin sulfate  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dioxygen  (EXP)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
fenvalerate  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Hexamethonium  (EXP)
icatibant  (EXP,ISO)
irbesartan  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitric oxide  (ISO)
nitroprusside  (EXP)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
parathion  (ISO)
PD123319  (EXP)
perfluorohexanesulfonic acid  (EXP)
perindopril  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
potassium dichromate  (EXP)
Pranoprofen  (EXP)
propranolol  (EXP)
ramiprilat  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal glomerular capillary morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal juxtaglomerular apparatus morphology  (IAGP)
abnormal juxtaglomerular cell morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney medullary ray morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal kidney vasculature morphology  (IAGP)
abnormal Leydig cell morphology  (IAGP)
abnormal mitochondrial chromosome morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatic cord morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
alopecia  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased bone mineral density  (IAGP)
decreased heart rate  (IAGP)
decreased hematocrit  (IAGP)
decreased kidney weight  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased urine nitrite level  (IAGP)
decreased urine osmolality  (IAGP)
dilated renal tubule  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating creatinine level  (IAGP)
increased glomerular capsule space  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
kidney cortex cyst  (IAGP)
kidney cyst  (IAGP)
kyphosis  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors. Abdouh M, etal., Br J Pharmacol. 2008 May;154(1):136-43. Epub 2008 Mar 3.
2. Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma. Akbary AM, etal., Immunopharmacology. 1996 Jun;33(1-3):238-42.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. Bertram CM, etal., J Leukoc Biol. 2009 Mar;85(3):544-52. Epub 2008 Nov 26.
5. Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. Bujalska M and Makulska-Nowak H, Neuro Endocrinol Lett. 2009 Mar;30(1):144-52.
6. Autoradiographic distribution and alterations of kinin B(2) receptors in the brain and spinal cord of streptozotocin-diabetic rats. Campos MM, etal., Synapse. 2005 Dec 1;58(3):184-92.
7. Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin. Chen CT, etal., Hepatogastroenterology. 2009 Sep-Oct;56(94-95):1261-7.
8. Pharmacologic and autoradiographic evidence for an up-regulation of kinin B(2) receptors in the spinal cord of spontaneously hypertensive rats. Cloutier F, etal., Br J Pharmacol. 2002 Apr;135(7):1641-54.
9. Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist -BK in a F98 glioma rat model: an MRI study. Cote J, etal., Neuropeptides. 2010 Apr;44(2):177-85. Epub 2010 Jan 18.
10. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Dabek J, etal., Scand Cardiovasc J. 2007 Dec;41(6):391-6.
11. Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. Ellis KM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):166-78. Epub 2004 Jan 15.
12. Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation. Feletou M, etal., J Pharmacol Exp Ther. 1995 Jun;273(3):1078-84.
13. Cyclooxygenase inhibitors attenuate bradykinin-induced vasoconstriction in septic isolated rat lungs. Fischer LG, etal., Anesth Analg. 2000 Mar;90(3):625-31.
14. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Gama Landgraf R, etal., Inflamm Res. 2004 Feb;53(2):78-83. Epub 2004 Jan 26.
15. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Grilo A, etal., Pharmacogenet Genomics. 2011 Jan;21(1):10-7.
16. +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease. Hopkinson NS, etal., Am J Clin Nutr. 2006 Apr;83(4):912-7.
17. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Kakoki M, etal., Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.
18. Polymorphisms in the bradykinin B2 receptor gene and childhood asthma. Kusser B, etal., Biol Chem. 2001 May;382(5):885-9.
19. Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. Lee YJ and Tsai JC, Metabolism. 2001 Nov;50(11):1346-50.
20. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Leeb-Lundberg LM, etal., Pharmacol Rev. 2005 Mar;57(1):27-77.
21. Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy. Majima M, etal., Br J Pharmacol. 1997 Jun;121(4):723-30.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
26. Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. Mukae S, etal., Hypertension. 2000 Jul;36(1):127-31.
27. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. Mukae S, etal., J Hum Hypertens. 2002 Dec;16(12):857-63.
28. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
29. Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy. Ongali B, etal., J Comp Neurol 2003 Jul 7;461(4):506-19.
30. Role of kinin B1 and B2 receptors in a rat model of neuropathic pain. Petcu M, etal., Int Immunopharmacol. 2008 Feb;8(2):188-96. Epub 2007 Sep 29.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia. Poole S, etal., Br J Pharmacol. 1999 Feb;126(3):649-56.
33. Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats. Qadri F, etal., Can J Physiol Pharmacol 2002 Apr;80(4):258-63.
34. Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers. Rajakulasingam K, etal., J Physiol. 1991 Jun;437:577-87.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. In vivo bradykinin B2 receptor activation reduces renal fibrosis. Schanstra JP, etal., J Clin Invest 2002 Aug;110(3):371-9.
39. Bradykinin down-regulates LPS-induced eosinophil accumulation in the pleural cavity of mice through type 2-kinin receptor activation: a role for prostaglandins. Silva AR, etal., Br J Pharmacol. 1999 May;127(2):569-75.
40. Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy. Spillmann F, etal., Int Immunopharmacol 2002 Dec;2(13-14):1823-32.
41. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Tan Y, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1026-35. Epub 2007 Jun 27.
42. Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy. Taraseviciene-Stewart L, etal., Peptides. 2005 Aug;26(8):1292-300.
43. Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen. Turner P, etal., J Allergy Clin Immunol. 2001 Jan;107(1):105-13.
44. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Wang DZ, etal., Hypertension. 1997 Jan;29(1 Pt 2):488-93.
45. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. Woo SW, etal., J Clin Pharm Ther. 2009 Oct;34(5):561-7.
46. Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy. Yuhki K, etal., J Pharmacol Exp Ther. 2004 Dec;311(3):1218-24. Epub 2004 Aug 17.
Additional References at PubMed
PMID:7532178   PMID:7665180   PMID:7749364   PMID:7775424   PMID:7959003   PMID:8166739   PMID:8302267   PMID:8394991   PMID:8652530   PMID:8713099   PMID:8846408   PMID:9030205  
PMID:9200178   PMID:9396457   PMID:9488225   PMID:9581559   PMID:9622142   PMID:9887344   PMID:9931125   PMID:10217521   PMID:10349636   PMID:10373229   PMID:10454437   PMID:10587341  
PMID:10601137   PMID:10604518   PMID:10614985   PMID:10642330   PMID:10710553   PMID:10859349   PMID:11015607   PMID:11042159   PMID:11076861   PMID:11179194   PMID:11217851   PMID:11282893  
PMID:11375278   PMID:11408397   PMID:11592936   PMID:11597990   PMID:11747905   PMID:11751717   PMID:11860272   PMID:11956243   PMID:11962729   PMID:12105144   PMID:12193127   PMID:12477932  
PMID:12504926   PMID:12560214   PMID:12604671   PMID:12637363   PMID:12654715   PMID:12759407   PMID:12805091   PMID:12872048   PMID:12953015   PMID:14610273   PMID:14764727   PMID:15123575  
PMID:15196965   PMID:15326315   PMID:15376229   PMID:15383401   PMID:15639479   PMID:15643126   PMID:15767251   PMID:15947253   PMID:16126915   PMID:16135755   PMID:16141072   PMID:16141073  
PMID:16497152   PMID:16514058   PMID:16534002   PMID:16571598   PMID:16602821   PMID:16604193   PMID:16735595   PMID:17056563   PMID:17255557   PMID:17289925   PMID:17328065   PMID:17339539  
PMID:17344422   PMID:17452647   PMID:17460297   PMID:17570564   PMID:17579666   PMID:17933966   PMID:18045900   PMID:18086683   PMID:18182230   PMID:18182239   PMID:18191900   PMID:18212275  
PMID:18347228   PMID:18467203   PMID:18566101   PMID:18753293   PMID:18783336   PMID:18787060   PMID:18824766   PMID:18927465   PMID:18986535   PMID:19017652   PMID:19453270   PMID:19494315  
PMID:19565561   PMID:19687097   PMID:19773800   PMID:19932979   PMID:19969036   PMID:20045188   PMID:20060587   PMID:20067469   PMID:20385709   PMID:20501666   PMID:20970438   PMID:21242838  
PMID:21267068   PMID:21401298   PMID:21470206   PMID:21486761   PMID:21704095   PMID:21719759   PMID:21804193   PMID:21840178   PMID:21873635   PMID:22079285   PMID:22132157   PMID:22220695  
PMID:22237799   PMID:22273860   PMID:22378823   PMID:22573379   PMID:22829877   PMID:22868909   PMID:22889120   PMID:23019230   PMID:23024762   PMID:23028588   PMID:23033373   PMID:23132855  
PMID:23151408   PMID:23275384   PMID:23351078   PMID:23386129   PMID:23390194   PMID:23454198   PMID:23811399   PMID:24020815   PMID:24025224   PMID:24380835   PMID:24478091   PMID:24975837  
PMID:25187655   PMID:26151827   PMID:26153520   PMID:26346752   PMID:26443866   PMID:26966276   PMID:27188843   PMID:28390948   PMID:28503149   PMID:29376892   PMID:29940664   PMID:29987507  
PMID:30281335   PMID:30338498   PMID:30503206   PMID:30575436   PMID:30847343   PMID:31039364   PMID:31234939   PMID:31640792   PMID:32222846   PMID:36641883   PMID:37464053   PMID:38338764  


Genomics

Comparative Map Data
Bdkrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912105,529,431 - 105,561,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12105,529,485 - 105,561,496 (+)EnsemblGRCm39 Ensembl
GRCm3812105,563,172 - 105,595,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12105,563,226 - 105,595,237 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712106,801,382 - 106,831,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,964,222 - 105,994,121 (+)NCBIMGSCv36mm8
Celera12106,797,782 - 106,827,683 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1255.76NCBI
BDKRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381496,204,839 - 96,244,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1496,204,679 - 96,244,166 (+)EnsemblGRCh38hg38GRCh38
GRCh371496,671,176 - 96,710,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361495,740,950 - 95,780,542 (+)NCBINCBI36Build 36hg18NCBI36
Build 341495,740,949 - 95,780,536NCBI
Celera1476,726,862 - 76,766,386 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1476,856,277 - 76,895,774 (+)NCBIHuRef
CHM1_11496,610,085 - 96,649,595 (+)NCBICHM1_1
T2T-CHM13v2.01490,436,088 - 90,475,413 (+)NCBIT2T-CHM13v2.0
Bdkrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86130,237,055 - 130,267,205 (+)NCBIGRCr8
mRatBN7.26124,472,317 - 124,502,497 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6124,472,566 - 124,502,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6124,593,665 - 124,623,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06124,888,932 - 124,918,906 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06124,250,138 - 124,280,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
RH 3.4 Map6815.41RGD
Cytogenetic Map6q32NCBI
Bdkrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543816,511,759 - 16,537,172 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543816,514,300 - 16,537,160 (-)NCBIChiLan1.0ChiLan1.0
BDKRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21597,363,214 - 97,404,173 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11496,579,702 - 96,620,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01476,832,833 - 76,873,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11496,157,122 - 96,196,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1496,156,494 - 96,196,253 (+)Ensemblpanpan1.1panPan2
BDKRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1864,974,588 - 65,005,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl864,974,997 - 65,003,407 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha864,490,876 - 64,519,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0865,246,390 - 65,277,067 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl865,246,390 - 65,274,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1864,919,488 - 64,947,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0864,980,727 - 65,009,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0865,304,383 - 65,332,835 (+)NCBIUU_Cfam_GSD_1.0
Bdkrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086409,528,206 - 9,533,778 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936604548,847 - 549,956 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936604548,844 - 551,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDKRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7117,438,713 - 117,472,005 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17117,438,622 - 117,472,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BDKRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12474,084,907 - 74,125,604 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2474,118,210 - 74,122,909 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605361,236,289 - 61,276,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdkrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,513,814 - 8,539,036 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,513,601 - 8,538,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bdkrb2
1318 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:177
Interacting mature miRNAs:192
Transcripts:ENSMUST00000001652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
25394546Skmw76_mskeletal muscle weight 76, TA (mouse)12102593095106941888Mouse

Markers in Region
X78438  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812105,592,890 - 105,592,979UniSTSGRCm38
MGSCv3712106,831,100 - 106,831,189UniSTSGRCm37
Celera12106,827,502 - 106,827,591UniSTS
Cytogenetic Map12EUniSTS
cM Map1253.0UniSTS
Whitehead/MRC_RH12968.01UniSTS
L27595  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812105,592,790 - 105,592,941UniSTSGRCm38
MGSCv3712106,831,000 - 106,831,151UniSTSGRCm37
Celera12106,827,402 - 106,827,553UniSTS
Cytogenetic Map12EUniSTS
cM Map1253.0UniSTS
Whitehead_YAC12 UniSTS
PMC150945P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812105,591,735 - 105,592,095UniSTSGRCm38
MGSCv3712106,829,945 - 106,830,305UniSTSGRCm37
Celera12106,826,347 - 106,826,707UniSTS
Cytogenetic Map12EUniSTS
cM Map1253.0UniSTS
RH94464  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812105,594,150 - 105,594,321UniSTSGRCm38
MGSCv3712106,832,360 - 106,832,531UniSTSGRCm37
Celera12106,828,762 - 106,828,933UniSTS
Cytogenetic Map12EUniSTS
cM Map1253.0UniSTS
PMC150944P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812105,591,725 - 105,592,296UniSTSGRCm38
MGSCv3712106,829,935 - 106,830,506UniSTSGRCm37
Celera12106,826,337 - 106,826,908UniSTS
Cytogenetic Map12EUniSTS
cM Map1253.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000001652   ⟹   ENSMUSP00000001652
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12105,529,485 - 105,561,496 (+)Ensembl
GRCm38.p6 Ensembl12105,563,226 - 105,595,237 (+)Ensembl
RefSeq Acc Id: NM_009747   ⟹   NP_033877
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912105,529,431 - 105,559,330 (+)NCBI
GRCm3812105,563,172 - 105,593,071 (+)NCBI
MGSCv3712106,801,382 - 106,831,281 (+)RGD
Celera12106,797,782 - 106,827,683 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006515442   ⟹   XP_006515505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912105,548,934 - 105,561,503 (+)NCBI
GRCm3812105,582,673 - 105,595,244 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011243991   ⟹   XP_011242293
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912105,548,934 - 105,561,503 (+)NCBI
GRCm3812105,582,673 - 105,595,244 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157172   ⟹   XP_036013065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912105,551,396 - 105,561,503 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033877   ⟸   NM_009747
- UniProtKB: B9EHE3 (UniProtKB/Swiss-Prot),   P32299 (UniProtKB/Swiss-Prot),   B2RQ47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515505   ⟸   XM_006515442
- Peptide Label: isoform X2
- UniProtKB: B9EHE3 (UniProtKB/Swiss-Prot),   P32299 (UniProtKB/Swiss-Prot),   B2RQ47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242293   ⟸   XM_011243991
- Peptide Label: isoform X1
- UniProtKB: B2RQ47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000001652   ⟸   ENSMUST00000001652
RefSeq Acc Id: XP_036013065   ⟸   XM_036157172
- Peptide Label: isoform X1
- UniProtKB: B2RQ47 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32299-F1-model_v2 AlphaFold P32299 1-392 view protein structure

Promoters
RGD ID:8679168
Promoter ID:EPDNEW_M17614
Type:multiple initiation site
Name:Bdkrb2_2
Description:Mus musculus bradykinin receptor, beta 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17615  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812105,563,130 - 105,563,190EPDNEW
RGD ID:8679170
Promoter ID:EPDNEW_M17615
Type:single initiation site
Name:Bdkrb2_1
Description:Mus musculus bradykinin receptor, beta 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17614  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812105,579,563 - 105,579,623EPDNEW
RGD ID:6822774
Promoter ID:MM_KWN:12638
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:NM_009747
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612106,801,061 - 106,801,561 (+)MPROMDB
RGD ID:6849009
Promoter ID:MM_XEF:1692
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Spleen
Transcripts:NM_001003095,   NM_001031553,   NM_001124498,   NM_001172920,   NM_214146
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612106,830,399 - 106,830,899 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102845 AgrOrtholog
Ensembl Genes ENSMUSG00000021070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001652 ENTREZGENE
  ENSMUST00000001652.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Brdyknn_2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Brdyknn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12062 UniProtKB/Swiss-Prot
MGD MGI:102845 ENTREZGENE
NCBI Gene 12062 ENTREZGENE
PANTHER B2 BRADYKININ RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BDKRB2 RGD
PhenoGen Bdkrb2 PhenoGen
PRINTS BRADYKININR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRADYKINNB2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RQ47 ENTREZGENE, UniProtKB/TrEMBL
  B9EHE3 ENTREZGENE
  BKRB2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B9EHE3 UniProtKB/Swiss-Prot