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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethanolamines
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Accession:CHEBI:23981 term browser browse the term
Synonyms:related_synonym: ethanolamine



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(-)-ephedrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 multiple interactions ISO [Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein CTD PMID:16324916 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions ISO [Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein CTD PMID:16324916 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein CTD PMID:16324916 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc1 apolipoprotein C1 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein CTD PMID:16324916 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G Apoc2 apolipoprotein C2 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein CTD PMID:16324916 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein CTD PMID:15537744 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cfd complement factor D multiple interactions ISO [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ephedrine results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G H2ax H2A.X variant histone multiple interactions EXP [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein CTD PMID:15537744 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
(R)-octopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein] CTD PMID:10344530 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein] CTD PMID:10344530 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 increases activity
multiple interactions
EXP
ISO
Octopamine results in increased activity of ADRB3 protein
Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]
CTD PMID:10344530 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity
ISO [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
9-[2-(phosphonomethoxy)ethyl]guanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases response to substance
ISO 9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]; Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog]
SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine; SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog
CTD PMID:23856525 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
acebutolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
increases activity
ISO [Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein] CTD PMID:12761341 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Acebutolol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ren renin decreases activity ISO
EXP
Acebutolol results in decreased activity of REN protein CTD PMID:6110712 PMID:6118215 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
acetophenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO acetophenazine binds to and results in decreased activity of AR protein CTD PMID:17606915 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
albuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
Albuterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] CTD PMID:8096834 PMID:14730417 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases response to substance
increases activity
multiple interactions
increases phosphorylation
decreases expression
ISO
EXP
ADRB2 gene polymorphism results in decreased susceptibility to Albuterol
Albuterol results in increased activity of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Albuterol binds to and results in increased activity of ADRB2 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]
Albuterol results in increased phosphorylation of ADRB2 protein
Albuterol results in decreased expression of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid; Albuterol binds to and results in increased activity of ADRB2 protein
CTD PMID:2463453 PMID:8102213 PMID:8937731 PMID:10516654 PMID:10952688 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Albuterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Albuterol binds to and results in increased activity of ADRB3 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Albuterol results in increased expression of BAX CTD PMID:11802967 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Albuterol results in decreased expression of BCL2 CTD PMID:11802967 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol] CTD PMID:19462961 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:12818968 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein CTD PMID:15679717 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Albuterol results in increased expression of CDK2 protein CTD PMID:18362475 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Albuterol results in increased expression of CDK4 protein CTD PMID:18362475 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Ckm creatine kinase, M-type increases secretion ISO Albuterol results in increased secretion of CKM protein CTD PMID:8970440 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein CTD PMID:15679717 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Albuterol results in increased expression of CYP17A1 CTD PMID:17822730 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Cyproterone co-treated with Albuterol] results in decreased expression of CYP19A1 CTD PMID:17822730 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Albuterol results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Il10 interleukin 10 decreases expression EXP Albuterol results in decreased expression of IL10 mRNA CTD PMID:16908771 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Albuterol results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Albuterol results in decreased expression of IL1B mRNA
CTD PMID:11112151 PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO Albuterol results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Albuterol results in increased expression of IL6 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:18362475 PMID:20388727 PMID:20519841 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 increases expression ISO Albuterol results in increased expression of INS; Albuterol results in increased expression of INS protein CTD PMID:8098220 PMID:9088585 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ldlr low density lipoprotein receptor affects response to substance ISO LDLR gene SNP affects the susceptibility to Albuterol CTD PMID:15453913 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:16980553 PMID:20519841 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:16980553 PMID:20519841 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol] CTD PMID:19462961 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Albuterol results in increased expression of NFKBIA protein CTD PMID:18362475 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:20519841 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein CTD PMID:15679717 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pde4a phosphodiesterase 4A multiple interactions ISO [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA CTD PMID:10763856 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO [Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA CTD PMID:10763856 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Albuterol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Albuterol results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Albuterol results in increased expression of PPARGC1A mRNA CTD PMID:17446185 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptafr platelet-activating factor receptor increases expression ISO Albuterol results in increased expression of PTAFR protein CTD PMID:18362475 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Albuterol results in decreased expression of PTGS2 mRNA
CTD PMID:11112151 PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions
increases expression
ISO Albuterol results in decreased expression of RB1 protein
ICI 118551 inhibits the reaction [Albuterol results in decreased expression of RB1 protein]
Albuterol results in increased expression of RB1 protein
CTD PMID:16446544 PMID:18362475 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Ren renin increases expression ISO Albuterol results in increased expression of REN protein CTD PMID:2829953 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Albuterol results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Albuterol results in decreased secretion of TNF protein
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
CTD PMID:8937731 PMID:10229875 PMID:20388727 PMID:20519841 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Albuterol results in increased expression of TP53 CTD PMID:11802967 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Albuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA CTD PMID:12824081 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
anandamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of anandamide CTD PMID:30102254 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression
ISO 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in decreased expression of ABCG2 mRNA]; anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]; iodopravadoline inhibits the reaction [anandamide results in decreased expression of ABCG2 mRNA]
anandamide results in decreased expression of ABCG2 mRNA; anandamide results in decreased expression of ABCG2 protein
CTD PMID:30610963 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G App amyloid beta precursor protein decreases response to substance
decreases metabolic processing
decreases abundance
EXP
ISO
anandamide results in decreased susceptibility to APP protein
APP protein results in decreased metabolism of anandamide
APP protein results in decreased abundance of anandamide
CTD PMID:22233683 PMID:26976670 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO anandamide promotes the reaction [CNR1 protein affects the localization of ARRB2 protein] CTD PMID:31024316 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions
decreases activity
ISO AM 251 inhibits the reaction [anandamide results in decreased activity of BDKRB1 protein] CTD PMID:19022239 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO anandamide results in increased cleavage of CASP3 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [anandamide results in increased cleavage of CASP3 protein]
CTD PMID:26513129 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd36 CD36 molecule increases expression ISO anandamide results in increased expression of CD36 mRNA; anandamide results in increased expression of CD36 protein CTD PMID:17360047 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide decreases expression ISO anandamide results in decreased expression of CGA mRNA CTD PMID:30610963 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Cnr1 cannabinoid receptor 1 affects activity
increases response to substance
decreases expression
affects binding
increases activity
multiple interactions
ISO
EXP
anandamide affects the activity of CNR1 protein
CNR1 protein results in increased susceptibility to anandamide
anandamide results in decreased expression of CNR1 protein
anandamide binds to CNR1 protein
anandamide results in increased activity of CNR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]; anandamide promotes the reaction [CNR1 protein affects the localization of ARRB2 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Pertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]; Rimonabant inhibits the reaction [anandamide results in increased activity of CNR1]
[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]
CTD PMID:10871313 PMID:11408034 PMID:11891798 PMID:12657697 PMID:14504685 More... NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 affects activity
multiple interactions
affects binding
ISO
EXP
anandamide affects the activity of CNR2 protein
anandamide binds to and results in increased activity of CNR2 protein; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]
anandamide binds to CNR2 protein
CTD PMID:10617657 PMID:10688601 PMID:15453094 PMID:19147270 PMID:30102254 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO anandamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]
anandamide results in decreased phosphorylation of CREB1 protein
CTD PMID:30610963 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone decreases abundance ISO CRH protein results in decreased abundance of anandamide CTD PMID:26821211 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions
increases metabolic processing
ISO cannabichromene inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; Cannabidiol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; cannabigerol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; Cannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; delta-8-tetrahydrocannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]; Dronabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide] CTD PMID:29689453 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO anandamide results in increased expression of DDIT3 mRNA; anandamide results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [anandamide results in increased expression of DDIT3 protein]
CTD PMID:21949157 PMID:26513129 PMID:29441458 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO anandamide results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [anandamide results in increased phosphorylation of EIF2S1 protein]
CTD PMID:26513129 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope decreases expression ISO anandamide results in decreased expression of ERVFRD-1 mRNA CTD PMID:30610963 NCBI chr12:22,151,211...22,158,264
Ensembl chr12:22,151,211...22,158,264
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
ISO anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
anandamide results in increased expression of F3 protein
CTD PMID:27556861 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Faah fatty acid amide hydrolase increases degradation
increases response to substance
decreases metabolic processing
multiple interactions
affects expression
ISO
EXP
FAAH results in increased degradation of anandamide
FAAH gene mutant form results in increased susceptibility to anandamide
FAAH gene mutant form results in decreased metabolism of anandamide
FAAH protein results in increased degradation of anandamide
[Chlorpyrifos results in decreased activity of FAAH protein] which results in increased abundance of anandamide; [cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of FAAH protein] which results in increased abundance of anandamide; [Lipopolysaccharides results in decreased expression of FAAH protein] which results in increased abundance of anandamide; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
anandamide affects the expression of FAAH protein
[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of FAAH protein] which results in decreased metabolism of anandamide; [nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]; [PF 3845 results in decreased activity of FAAH protein] which results in decreased metabolism of anandamide; Rimonabant inhibits the reaction [FAAH gene mutant form results in increased susceptibility to anandamide]
CTD PMID:11556820 PMID:16131814 PMID:16886060 PMID:19515121 PMID:20702753 More... NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
affects abundance
affects binding
EXP
ISO
11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [anandamide analog binds to FABP1 protein]; Dronabinol inhibits the reaction [anandamide analog binds to FABP1 protein]
FABP1 protein affects the abundance of anandamide
FABP1 protein affects the reaction [Dronabinol results in increased abundance of anandamide]; FABP1 protein affects the reaction [glyceryl 2-arachidonate results in increased abundance of anandamide]
CTD PMID:29414765 PMID:30232874 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; capsazepine inhibits the reaction [anandamide results in increased expression of FOS protein]; resiniferatoxin inhibits the reaction [anandamide results in increased expression of FOS protein]
anandamide results in increased expression of FOS; anandamide results in increased expression of FOS protein
CTD PMID:9748483 PMID:15601931 PMID:19515121 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Ifng interferon gamma multiple interactions ISO anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]; anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B] CTD PMID:12813001 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO anandamide results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il12b interleukin 12B multiple interactions ISO [OMDM-1 cpd co-treated with anandamide] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15748152 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO anandamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL1B protein]]
anandamide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of IL1B]; anandamide promotes the reaction [IL1B protein results in increased expression of F3 protein]
CTD PMID:12813001 PMID:15748152 PMID:27556861 PMID:30611738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]] CTD PMID:30611738 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lep leptin decreases abundance
multiple interactions
decreases activity
decreases transport
ISO LEP protein results in decreased abundance of anandamide
Dietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide]
LEP protein results in decreased activity of anandamide
LEP protein results in decreased transport of anandamide
CTD PMID:16154199 PMID:29967158 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:12657697 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein; U 0126 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K2 protein] CTD PMID:12657697 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
anandamide results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK1 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein; Rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:12657697 PMID:19477951 PMID:21179406 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; CNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
anandamide results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [anandamide results in increased phosphorylation of MAPK3 protein]; JTE 907 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pertussis Toxin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; rimonabant inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:12657697 PMID:19477951 PMID:21179406 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO anandamide results in increased expression of MMP1 mRNA CTD PMID:16330497 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO anandamide results in increased expression of MMP3 mRNA CTD PMID:16330497 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of MMP9 mRNA] CTD PMID:16330497 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; anandamide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:11891798 PMID:15748152 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO anandamide results in increased cleavage of PARP1 protein CTD PMID:29441458 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO anandamide binds to and results in increased activity of PPARA protein CTD PMID:17906680 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases metabolic processing
EXP
ISO
[nimesulide results in decreased expression of PTGS2] which results in increased activity of anandamide
anandamide results in increased expression of PTGS2 mRNA; anandamide results in increased expression of PTGS2 protein
PTGS2 results in increased metabolism of anandamide
[nimesulide results in decreased expression of PTGS2] promotes the reaction [FAAH affects the metabolism of anandamide]
CTD PMID:16330497 PMID:17245358 PMID:20702753 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Selp selectin P multiple interactions
increases expression
ISO anandamide inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased expression of SELP protein]
anandamide results in increased expression of SELP protein
CTD PMID:27151562 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO anandamide results in increased expression of TIMP1 mRNA
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [anandamide results in increased expression of TIMP1 mRNA]
CTD PMID:16330497 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
EXP
ISO
anandamide inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]
anandamide inhibits the reaction [[Serotonin co-treated with Dextran Sulfate] results in increased expression of TNF protein]
TNF protein results in increased abundance of anandamide
anandamide affects the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased secretion of TNF]
CTD PMID:12509806 PMID:12813001 PMID:20626112 PMID:30611738 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases response to substance
increases activity
affects response to substance
affects binding
ISO
EXP
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; capsazepine inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; CNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]; CNR2 affects the reaction [TRPV1 affects the susceptibility to anandamide]; Egtazic Acid inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; methyl arachidonylfluorophosphonate promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; N-(2-methyl-3-hydroxyphenyl)-5,8,11,14-eicosatetraenamide inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Nitroprusside promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; Phenylmethylsulfonyl Fluoride promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; rimonabant inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]
TRPV1 protein results in increased susceptibility to anandamide
anandamide results in increased activity of TRPV1 protein
anandamide binds to TRPV1 protein
3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [anandamide promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; anandamide binds to and results in increased activity of TRPV1 protein; bisindolylmaleimide inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Eicosapentaenoic Acid inhibits the reaction [anandamide results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [anandamide results in increased activity of TRPV1 protein]
CTD PMID:11140687 PMID:11278420 PMID:14504685 PMID:15453094 PMID:15601931 More... NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO anandamide results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:15313899 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Atenolol inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atenolol results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Adra2a adrenoceptor alpha 2A affects response to substance ISO ADRA2A gene SNP affects the susceptibility to Atenolol CTD PMID:15614026 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adrb1 adrenoceptor beta 1 decreases activity
multiple interactions
affects binding
affects response to substance
decreases expression
ISO
EXP
Atenolol results in decreased activity of ADRB1 protein
Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
Atenolol binds to ADRB1 protein
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine; [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Atenolol
Atenolol results in decreased expression of ADRB1 mRNA
CTD PMID:1389726 PMID:2462161 PMID:2897299 PMID:8102213 PMID:8386603 More... NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression
affects binding
multiple interactions
ISO
EXP
Atenolol results in increased expression of ADRB2 protein
Atenolol binds to ADRB2 protein
Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]
CTD PMID:2462161 PMID:6093157 PMID:9593075 PMID:11425575 PMID:11483288 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Atenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Agt angiotensinogen affects response to substance
decreases expression
ISO AGT gene SNP affects the susceptibility to Atenolol
Atenolol results in decreased expression of AGT protein
CTD PMID:14639093 PMID:14700505 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Amy1 amylase alpha 1 multiple interactions EXP Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Cisplatin results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Atenolol results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Atenolol results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Apob apolipoprotein B increases expression ISO Atenolol results in increased expression of APOB; Atenolol results in increased expression of APOB protein CTD PMID:1928808 PMID:2193493 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein] CTD PMID:16671086 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO Atenolol results in decreased expression of B2M protein CTD PMID:2656332 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 exon polymorphism affects the susceptibility to Atenolol CTD PMID:12640257 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases response to substance ISO CACNA1C gene polymorphism results in increased susceptibility to Atenolol CTD PMID:20031608 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] CTD PMID:10728402 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]] CTD PMID:2575990 PMID:22391854 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] CTD PMID:9593584 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein] CTD PMID:16671086 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Edn1 endothelin 1 affects response to substance ISO EDN1 gene polymorphism affects the susceptibility to Atenolol CTD PMID:15188945 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein] CTD PMID:16671086 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO Atenolol results in decreased expression of FKBP5 mRNA CTD PMID:19915711 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Atenolol results in increased expression of GJA1 protein CTD PMID:16448880 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Atenolol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 decreases expression ISO Atenolol results in decreased expression of GRK2 mRNA; Atenolol results in decreased expression of GRK2 protein CTD PMID:9788834 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects response to substance ISO KCNJ2 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 affects response to substance ISO KCNQ1 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO LIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G LOC120096121 small nucleolar RNA SNORA49 increases expression ISO Atenolol results in increased expression of SNORA49 mRNA CTD PMID:19915711 NCBI chr12:45,970,884...45,971,016
Ensembl chr12:45,970,884...45,971,016
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein] CTD PMID:16671086 PMID:17003101 PMID:17925438 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein] CTD PMID:16671086 PMID:17003101 PMID:17925438 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:19439816 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Atenolol results in decreased expression of NPPA protein CTD PMID:12866806 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
increases expression
EXP
ISO
[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
Atenolol results in decreased expression of NPPB mRNA
Atenolol results in increased expression of NPPB protein
CTD PMID:15969258 PMID:18192850 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Pla2g4c phospholipase A2 group IVC multiple interactions ISO PLA2G4C gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr 1:74,249,688...74,272,133
Ensembl chr 1:74,236,211...74,274,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] CTD PMID:17003101 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
JBrowse link
G Ren renin multiple interactions
decreases expression
decreases activity
ISO
EXP
[aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein
Atenolol results in decreased expression of REN protein
Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
Atenolol results in decreased activity of REN protein
CTD PMID:3142437 PMID:3333524 PMID:9300315 PMID:14639093 PMID:18957387 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Ryr2 ryanodine receptor 2 increases activity
multiple interactions
ISO Atenolol results in increased activity of RYR2 protein
Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Atenolol results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc6a8 solute carrier family 6 member 8 decreases expression ISO Atenolol results in decreased expression of SLC6A8 mRNA CTD PMID:19915711 NCBI chr  X:151,384,675...151,393,979
Ensembl chr  X:151,384,675...151,393,979
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases expression ISO Atenolol results in increased expression of SLCO4C1 mRNA CTD PMID:19915711 NCBI chr 9:97,180,162...97,229,135
Ensembl chr 9:97,178,861...97,229,715
JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N increases expression ISO Atenolol results in increased expression of SNRPN mRNA CTD PMID:19915711 NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]
CTD PMID:2575990 PMID:11163531 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]
CTD PMID:2575990 PMID:11163531 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atenolol CTD PMID:29627347 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Atenolol results in increased expression of TXN mRNA CTD PMID:19915711 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380 PMID:18582854 PMID:18977317 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
clenbuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Clenbuterol results in increased expression of ACADM mRNA CTD PMID:17446185 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO
EXP
[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose; ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose] CTD PMID:16007677 PMID:18552870 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP Clenbuterol binds to and results in increased activity of ADRB3 protein CTD PMID:7815362 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein] CTD PMID:16339297 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]] CTD PMID:15710352 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]] CTD PMID:15710352 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Clenbuterol results in increased expression of ESRRA mRNA CTD PMID:17446185 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]; Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]] CTD PMID:8774452 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression
ISO
EXP
Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Clenbuterol affects the expression of IL10 protein
CTD PMID:15021963 PMID:15502056 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 increases expression ISO Clenbuterol results in increased expression of IL18 mRNA; Clenbuterol results in increased expression of IL18 protein CTD PMID:15178407 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:15021963 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:15021963 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:15502056 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases stability
increases activity
ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]
Clenbuterol results in increased stability of ODC1 protein
CTD PMID:10353628 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clenbuterol results in increased expression of PDK4 mRNA CTD PMID:17446185 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Clenbuterol results in increased expression of PPARGC1A mRNA
Propranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]
CTD PMID:17446185 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clenbuterol affects the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15710352 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Clenbuterol results in increased expression of TFAM mRNA CTD PMID:17446185 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15021963 PMID:15710352 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Clenbuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
clorprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clorprenaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
diethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death decreases expression ISO
EXP
diethanolamine results in decreased expression of BAD mRNA CTD PMID:16014740 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP
ISO
diethanolamine results in decreased expression of BAX mRNA CTD PMID:16014740 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 decreases expression
increases activity
ISO
EXP
diethanolamine results in decreased expression of CASP3 mRNA
diethanolamine results in increased activity of CASP3 protein
CTD PMID:16014740 PMID:18948303 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO
EXP
diethanolamine results in increased expression of CCND2 mRNA CTD PMID:16014740 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 increases expression ISO
EXP
diethanolamine results in increased expression of CCNE1 mRNA CTD PMID:16014740 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO
EXP
diethanolamine results in decreased expression of CDKN1A mRNA CTD PMID:16014740 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO
EXP
diethanolamine results in decreased expression of CDKN1B mRNA CTD PMID:16014740 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO
EXP
diethanolamine results in increased expression of E2F1 mRNA CTD PMID:16014740 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [diethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO diethanolamine results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO
EXP
diethanolamine results in decreased expression of TRP53 mRNA
diethanolamine results in decreased expression of TP53 mRNA
CTD PMID:16014740 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
esmolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO esmolol results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO esmolol results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin increases expression ISO esmolol results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP esmolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein] CTD PMID:16627864 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO esmolol results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO esmolol results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO esmolol results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO esmolol results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO esmolol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO esmolol results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ren renin multiple interactions ISO esmolol inhibits the reaction [Nitroprusside results in increased activity of REN protein] CTD PMID:2569849 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO esmolol results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO esmolol results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
etanidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Etanidazole CTD PMID:2943713 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
ethambutol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Ethambutol results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Ethambutol results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Cat catalase multiple interactions EXP [isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in decreased activity of CAT protein CTD PMID:34118364 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression EXP Ethambutol affects the expression of CCL2 mRNA CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Ethambutol affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Ethambutol results in increased expression of and affects the localization of CTSD protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein] CTD PMID:19063910 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Ethambutol results in decreased activity of CYP1A2 protein CTD PMID:24910189 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Ethambutol results in decreased activity of CYP2C19 protein CTD PMID:24910189 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Ethambutol results in decreased activity of CYP2D6 protein CTD PMID:24910189 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
Ethambutol results in decreased activity of CYP2E1 protein
[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]
CTD PMID:24910189 PMID:27919644 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gzmb granzyme B increases secretion ISO Ethambutol results in increased secretion of GZMB protein CTD PMID:27933861 NCBI chr15:30,343,361...30,346,792
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G Ifng interferon gamma increases secretion ISO Ethambutol results in increased secretion of IFNG protein CTD PMID:27933861 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 decreases expression EXP Ethambutol results in decreased expression of IL10 protein CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 increases secretion ISO Ethambutol results in increased secretion of IL13 protein CTD PMID:27933861 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Ethambutol results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Ethambutol results in decreased expression of IL1B mRNA CTD PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression EXP Ethambutol results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression
multiple interactions
EXP Ethambutol results in increased expression of LAMP2 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of LAMP2 protein]
CTD PMID:19063910 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lep leptin decreases expression EXP Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Ethambutol results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein CTD PMID:34118364 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Ethambutol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ethambutol results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Ethambutol results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Ethambutol results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
ethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B multiple interactions EXP [3-deazaadenosine co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form; [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form; [Clofibric Acid co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form CTD PMID:8944747 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E multiple interactions EXP [3-deazaadenosine co-treated with Ethanolamine] results in decreased secretion of APOE protein; [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOE protein; [Clofibric Acid co-treated with Ethanolamine] results in decreased secretion of APOE protein CTD PMID:8944747 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Egf epidermal growth factor increases activity ISO Ethanolamine results in increased activity of EGF protein CTD PMID:15802876 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fgf1 fibroblast growth factor 1 increases activity ISO Ethanolamine results in increased activity of FGF1 protein CTD PMID:15802876 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 increases metabolic processing EXP PNLIPRP2 protein results in increased metabolism of Ethanolamine CTD PMID:9822688 NCBI chr 1:257,897,766...257,916,434
Ensembl chr 1:257,897,766...257,916,434
JBrowse link
indinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Indinavir results in decreased activity of ABCB11 protein
Indinavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Indinavir inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Indinavir inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:18343489 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
ISO Indinavir results in decreased expression of ADIPOQ protein
diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of ADIPOQ protein]; Indinavir inhibits the reaction [ADIPOQ protein modified form results in increased uptake of Deoxyglucose]
Indinavir results in decreased expression of ADIPOQ mRNA; Indinavir results in decreased expression of ADIPOQ protein
CTD PMID:15865214 PMID:17668557 PMID:29991592 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Aebp1 AE binding protein 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA CTD PMID:16931933 NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA CTD PMID:16931933 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO AGN 193109 inhibits the reaction [Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein]]; Indinavir promotes the reaction [Tretinoin results in increased expression of ALPL protein] CTD PMID:10704935 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Apob apolipoprotein B decreases secretion ISO Indinavir results in decreased secretion of APOB protein CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc3 apolipoprotein C3 decreases secretion
decreases expression
ISO Indinavir results in decreased secretion of APOC3 protein
Indinavir results in decreased expression of APOC3 mRNA
CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA CTD PMID:16931933 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Asic2 acid sensing ion channel subunit 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA CTD PMID:16931933 NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA CTD PMID:11706060 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G C1r complement C1r multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA CTD PMID:16931933 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C3ar1 complement C3a receptor 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA CTD PMID:16931933 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Indinavir results in increased expression of CCL2 protein
diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of CCL2 protein]
CTD PMID:17668557 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Indinavir results in increased expression of CCL3 protein CTD PMID:17668557 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA CTD PMID:16931933 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA CTD PMID:16931933 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
JBrowse link
G Clcn3 chloride voltage-gated channel 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA CTD PMID:16931933 NCBI chr16:29,127,419...29,200,133
Ensembl chr16:29,127,419...29,200,119
JBrowse link
G Crp C-reactive protein decreases expression ISO Indinavir results in decreased expression of CRP protein CTD PMID:15622323 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Dcn decorin multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA CTD PMID:16931933 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Indinavir results in increased expression of DDIT3 mRNA CTD PMID:32535746 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dusp3 dual specificity phosphatase 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA CTD PMID:16931933 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Indinavir results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA CTD PMID:16931933 NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA CTD PMID:16931933 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Etv6 ETS variant transcription factor 6 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA CTD PMID:16931933 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA CTD PMID:16931933 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Faim Fas apoptotic inhibitory molecule multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA CTD PMID:16931933 NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
ISO Indinavir results in increased expression of FASN mRNA
[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA
CTD PMID:11741158 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G G0s2 G0/G1switch 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA CTD PMID:16931933 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G Ganc glucosidase, alpha; neutral C multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA CTD PMID:16931933 NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA CTD PMID:16931933 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA CTD PMID:16931933 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA CTD PMID:16931933 NCBI chr 2:49,495,771...49,899,702
Ensembl chr 2:49,495,771...49,899,774
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Indinavir results in increased expression of HSPA5 mRNA CTD PMID:32535746 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ikzf4 IKAROS family zinc finger 4 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA CTD PMID:16931933 NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of IL6 protein] CTD PMID:17668557 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klhl28 kelch-like family member 28 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA CTD PMID:16931933 NCBI chr 6:82,987,360...83,018,971
Ensembl chr 6:82,990,945...83,016,164
JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA CTD PMID:16931933 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Lep leptin multiple interactions
decreases expression
ISO diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA
CTD PMID:16931933 PMID:17668557 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lpl lipoprotein lipase decreases activity
multiple interactions
increases expression
ISO Indinavir results in decreased activity of LPL protein
[Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA
Indinavir results in increased expression of LPL mRNA
CTD PMID:11741158 PMID:11786383 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Me1 malic enzyme 1 multiple interactions ISO [Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA CTD PMID:11741158 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mgat4c MGAT4 family, member C multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA CTD PMID:16931933 NCBI chr 7:36,709,564...37,485,810
Ensembl chr 7:37,260,321...37,474,571
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein] CTD PMID:14662518 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Indinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein] CTD PMID:14662518 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrap melanocortin 2 receptor accessory protein multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA CTD PMID:16931933 NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Indinavir results in decreased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Myod1 myogenic differentiation 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA CTD PMID:16931933 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Nap1l5 nucleosome assembly protein 1-like 5 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA CTD PMID:16931933 NCBI chr 4:88,022,670...88,024,988
Ensembl chr 4:88,022,569...88,024,654
JBrowse link
G Noct nocturnin multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA CTD PMID:16931933 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA CTD PMID:11706060 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Indinavir results in increased expression of NRF1 mRNA CTD PMID:17926646 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Nup210 nucleoporin 210 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA CTD PMID:16931933 NCBI chr 4:123,511,559...123,609,874
Ensembl chr 4:123,511,559...123,609,874
JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA CTD PMID:16931933 NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression ISO Indinavir results in increased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Pcdh15 protocadherin related 15 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA CTD PMID:16931933 NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA CTD PMID:16931933 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
JBrowse link
G Phf6 PHD finger protein 6 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA CTD PMID:16931933 NCBI chr  X:132,656,658...132,699,720
Ensembl chr  X:132,656,672...132,699,127
JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA CTD PMID:16931933 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Piwil2 piwi-like RNA-mediated gene silencing 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA CTD PMID:16931933 NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702
JBrowse link
G Porcn porcupine O-acyltransferase multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA CTD PMID:16931933 NCBI chr  X:14,285,864...14,298,481
Ensembl chr  X:14,285,871...14,298,481
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA CTD PMID:16931933 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Indinavir results in decreased expression of PPARG mRNA CTD PMID:17926646 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA CTD PMID:16931933 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Reep6 receptor accessory protein 6 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA CTD PMID:16931933 NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
JBrowse link
G RGD1562378 histone H4 variant H4-v.1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA CTD PMID:16931933
G Rnf151 ring finger protein 151 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA CTD PMID:16931933 NCBI chr10:13,742,682...13,747,192
Ensembl chr10:13,742,682...13,745,000
JBrowse link
G Rpain RPA interacting protein multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA CTD PMID:16931933 NCBI chr10:55,692,410...55,699,910
Ensembl chr10:55,692,417...55,699,933
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA CTD PMID:16931933 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G Slc25a19 solute carrier family 25 member 19 multiple interactions ISO SLC25A19 protein affects the susceptibility to [Stavudine co-treated with Lamivudine co-treated with Indinavir]; SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir] CTD PMID:15951836 NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP [Indinavir results in decreased activity of SLC2A4 protein] inhibits the reaction [resveratrol results in increased uptake of Deoxyglucose] CTD PMID:18601907 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Spink5 serine peptidase inhibitor, Kazal type 5 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA CTD PMID:16931933 NCBI chr18:36,264,452...36,333,143
Ensembl chr18:36,264,452...36,332,185
JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO Indinavir results in decreased expression of TFAP2A mRNA CTD PMID:17926646 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA CTD PMID:16931933 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Indinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:15388451 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trim42 tripartite motif-containing 42 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA CTD PMID:16931933 NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268
JBrowse link
G Ucp1 uncoupling protein 1 decreases expression ISO Indinavir results in decreased expression of UCP1 mRNA CTD PMID:17926646 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Wnt10a Wnt family member 10A multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA CTD PMID:16931933 NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
JBrowse link
lysophosphatidylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of BIRC3 protein] CTD PMID:25125499 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in increased cleavage of CASP3 protein]
CTD PMID:25125499 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
increases expression
ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of CFLAR mRNA]
lysophosphatidylethanolamine analog results in increased expression of CFLAR protein
Glycochenodeoxycholic Acid promotes the reaction [lysophosphatidylethanolamine analog results in increased expression of CFLAR protein]; lysophosphatidylethanolamine analog promotes the reaction [Glycochenodeoxycholic Acid results in increased expression of CFLAR protein]
lysophosphatidylethanolamine analog results in increased expression of CFLAR mRNA; lysophosphatidylethanolamine analog results in increased expression of CFLAR protein
CTD PMID:25125499 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [lysophosphatidylethanolamine analog co-treated with cobaltous chloride] results in increased phosphorylation of GSK3B protein CTD PMID:25125499 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of and results in increased degradation of MCL1 protein]
lysophosphatidylethanolamine analog results in increased expression of MCL1 protein
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of and results in increased degradation of MCL1 protein]
CTD PMID:25125499 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine; [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine analog CTD PMID:29515023 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of PARP1 protein] CTD PMID:25125499 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine CTD PMID:30258081 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
metaproterenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 decreases expression
affects expression
increases phosphorylation
multiple interactions
ISO Metaproterenol results in decreased expression of ADRB2 protein
Metaproterenol affects the expression of ADRB2 mRNA
Metaproterenol results in increased phosphorylation of ADRB2 protein
[Metaproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Metaproterenol binds to and results in increased activity of ADRB2 protein
CTD PMID:16980553 PMID:24705868 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Metaproterenol results in increased expression of BAX protein CTD PMID:15052282 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Metaproterenol results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Metaproterenol results in decreased expression of BCL2 protein CTD PMID:15052282 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Metaproterenol results in increased expression of BNIP1 protein CTD PMID:15052282 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
JBrowse link
G Clu clusterin increases expression ISO Metaproterenol results in increased expression of CLU protein CTD PMID:15052282 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Metaproterenol results in increased expression of FABP3 protein CTD PMID:22878004 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Metaproterenol results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Metaproterenol results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Metaproterenol results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Metaproterenol results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Metaproterenol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Metaproterenol results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Metaproterenol results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Metaproterenol results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Metaproterenol results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Metaproterenol results in increased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Metaproterenol results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Metaproterenol results in increased expression of TIMP1 mRNA CTD PMID:23558518 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression EXP Metaproterenol results in increased expression of TNNI3 protein CTD PMID:22878004 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression EXP Metaproterenol results in increased expression of TNNT2 protein CTD PMID:22878004 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
N,N-dimethylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Deanol inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
N-methylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh3 histamine receptor H3 multiple interactions ISO
EXP
N-methylaminoethanol binds to and results in decreased activity of HRH3 protein CTD PMID:17169555 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
octopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein] CTD PMID:10344530 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein] CTD PMID:10344530 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 increases activity
multiple interactions
EXP
ISO
Octopamine results in increased activity of ADRB3 protein
Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]
CTD PMID:10344530 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity
ISO [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
oleoyl ethanolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of N-oleoylethanolamine CTD PMID:30102254 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases response to substance
multiple interactions
ISO PPARA results in increased susceptibility to N-oleoylethanolamine
N-oleoylethanolamine binds to and results in increased activity of PPARA protein
CTD PMID:17906680 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO N-oleoylethanolamine results in decreased expression of PTGS2 protein CTD PMID:17906680 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
olomoucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
ISO
EXP
olomoucine results in decreased activity of CDK2 protein
olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein]
CTD PMID:12387751 PMID:15026556 PMID:20149834 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO olomoucine results in increased expression of RB1 mRNA; olomoucine results in increased expression of RB1 protein CTD PMID:14653808 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO olomoucine results in increased expression of SP1 mRNA; olomoucine results in increased expression of SP1 protein CTD PMID:14653808 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 multiple interactions ISO olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein] CTD PMID:20149834 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
oxybuprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO benoxinate results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
palmitoyl ethanolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of palmidrol CTD PMID:30102254 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Apob apolipoprotein B affects folding ISO palmidrol affects the folding of APOB protein CTD PMID:16115474 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO [palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA] CTD PMID:31054246 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 affects expression ISO palmidrol affects the expression of AQP4 mRNA CTD PMID:31054246 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Cldn3 claudin 3 multiple interactions
decreases expression
ISO [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA
palmidrol results in decreased expression of CLDN3 mRNA
CTD PMID:31054246 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cldn5 claudin 5 decreases expression ISO palmidrol results in decreased expression of CLDN5 mRNA CTD PMID:31054246 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP [rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog CTD PMID:17558434 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 affects binding
multiple interactions
ISO
EXP
palmidrol binds to CNR2 protein
[SR 144528 binds to and results in decreased activity of CNR2 protein] which results in decreased susceptibility to palmidrol analog
CTD PMID:10617657 PMID:10688601 PMID:17558434 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein] CTD PMID:26474837 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Ifng interferon gamma multiple interactions ISO [palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA] CTD PMID:31054246 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [hempseed oil co-treated with palmidrol] results in decreased expression of IL10 mRNA CTD PMID:33722712 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [hempseed oil co-treated with palmidrol] results in decreased expression of IL6 mRNA CTD PMID:33722712 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein] CTD PMID:26474837 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects localization
EXP [MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to palmidrol analog; [palmidrol co-treated with glyceryl 2-arachidonate] affects the localization of PPARA protein; [palmidrol co-treated with glyceryl 2-arachidonate] affects the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of PPARA protein]
palmidrol affects the localization of PPARA protein
CTD PMID:17558434 PMID:31787870 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA] CTD PMID:31054246 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA] CTD PMID:31054246 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
penbutolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Penbutolol results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Penbutolol results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ereg epiregulin increases expression ISO Penbutolol results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Penbutolol results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Penbutolol results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO Penbutolol results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Penbutolol results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Penbutolol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Penbutolol results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Penbutolol results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Penbutolol results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
perphenazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D multiple interactions ISO Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Perphenazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Perphenazine results in decreased expression of FSHB protein CTD PMID:6770916 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Perphenazine results in decreased activity of KCNH2 protein
CTD PMID:21158687 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Perphenazine results in decreased expression of LHB protein CTD PMID:6770916 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,898,267...95,901,963
Ensembl chr 1:95,898,267...95,901,963
JBrowse link
G Prl prolactin increases expression ISO
EXP
Perphenazine results in increased expression of PRL protein CTD PMID:6770916 PMID:7262630 PMID:17335319 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Perphenazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression ISO Perphenazine results in increased expression of TNNI3 protein CTD PMID:14742781 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP Phenylephrine results in decreased expression of ABCC9 mRNA CTD PMID:18158353 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Phenylephrine results in increased expression of ABHD2 mRNA CTD PMID:18158353 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
affects response to substance
increases phosphorylation
EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
ABL1 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased phosphorylation of ABL1 protein
CTD PMID:17615370 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
decreases expression
EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA] CTD PMID:19699196 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ACAT2 mRNA CTD PMID:18158353 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Ace angiotensin I converting enzyme affects response to substance ISO ACE protein affects the susceptibility to Phenylephrine CTD PMID:18431347 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Phenylephrine results in increased expression of ACOT2 mRNA CTD PMID:18158353 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions
increases expression
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]
CTD PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More... NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
EXP MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA] CTD PMID:16556869 PMID:18158353 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actr3 actin related protein 3 increases expression EXP Phenylephrine results in increased expression of ACTR3 mRNA CTD PMID:18158353 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein] CTD PMID:16760267 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Phenylephrine CTD PMID:12869393 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression EXP Phenylephrine results in decreased expression of ADHFE1 mRNA CTD PMID:18158353 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
JBrowse link
G Adm adrenomedullin multiple interactions
increases expression
decreases secretion
decreases expression
decreases response to substance
EXP
ISO
[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in decreased expression of ADM mRNA
ADM protein results in decreased susceptibility to Phenylephrine
CTD PMID:11470465 PMID:15370692 PMID:17250927 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
increases expression
EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein
CTD PMID:19966059 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
increases expression
EXP 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein
CTD PMID:19966059 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions
increases expression
EXP 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein
CTD PMID:19966059 Ensembl chr 2:193,388,713...193,392,357 JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 increases expression EXP Phenylephrine results in increased expression of ADPRHL1 mRNA CTD PMID:18158353 NCBI chr16:76,283,199...76,298,614
Ensembl chr16:76,283,103...76,354,440
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects activity
increases response to substance
affects binding
affects response to substance
ISO
EXP
5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein affects the susceptibility to Phenylephrine
CTD PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More... NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B affects response to substance
multiple interactions
increases activity
decreases expression
increases response to substance
ISO
EXP
ADRA1B protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
ADRA1B protein results in increased susceptibility to Phenylephrine
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
CTD PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More... NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance
ISO
EXP
ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine
CTD PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More... NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] CTD PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2b adrenoceptor alpha 2B affects response to substance
multiple interactions
ISO ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]
CTD PMID:16815979 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine] CTD PMID:16474418 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases response to substance
ISO amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine] CTD PMID:16022967 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Agt angiotensinogen affects response to substance
increases response to substance
multiple interactions
increases expression
EXP
ISO
AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]
CTD PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
affects response to substance
EXP
ISO
[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine
CTD PMID:11714657 PMID:19151255 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Phenylephrine results in increased expression of AIFM1 protein CTD PMID:31605733 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ak4 adenylate kinase 4 increases expression EXP Phenylephrine results in increased expression of AK4 mRNA CTD PMID:18158353 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation
ISO
EXP
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein
CTD PMID:10679475 PMID:18084315 PMID:28759639 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression EXP Phenylephrine results in increased expression of ALDH18A1 mRNA CTD PMID:18158353 NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
JBrowse link
G Angpt1 angiopoietin 1 multiple interactions
increases expression
ISO ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein
CTD PMID:18502941 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Phenylephrine results in decreased expression of ANGPTL4 mRNA CTD PMID:18158353 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Apoe apolipoprotein E affects response to substance ISO APOE protein affects the susceptibility to Phenylephrine CTD PMID:17899169 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Areg amphiregulin increases expression EXP Phenylephrine results in increased expression of AREG mRNA CTD PMID:18158353 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression EXP Phenylephrine results in decreased expression of ARHGEF12 mRNA CTD PMID:18158353 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP Phenylephrine results in decreased expression of ARRDC3 mRNA CTD PMID:18158353 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asb18 ankyrin repeat and SOCS box-containing 18 decreases expression EXP Phenylephrine results in decreased expression of ASB18 mRNA CTD PMID:18158353 NCBI chr 9:90,531,350...90,595,953
Ensembl chr 9:90,531,596...90,595,848
JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 increases expression EXP Phenylephrine results in increased expression of ASB4 mRNA CTD PMID:18158353 NCBI chr 4:33,506,992...33,544,630
Ensembl chr 4:33,506,992...33,544,630
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Phenylephrine results in increased expression of ASNS mRNA CTD PMID:18158353 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP Phenylephrine results in increased expression of ATF5 mRNA CTD PMID:18158353 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Phenylephrine results in increased expression of ATP1B1 mRNA CTD PMID:11204457 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
decreases expression
affects response to substance
increases expression
decreases activity
ISO
EXP
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
ATP2A2 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of ATP2A2 mRNA
Phenylephrine results in decreased activity of ATP2A2 protein
CTD PMID:11499749 PMID:11577024 PMID:15795322 PMID:16236312 PMID:17287366 More... NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 increases response to substance ISO ATP2B4 protein results in increased susceptibility to Phenylephrine CTD PMID:12933703 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) increases expression EXP Phenylephrine results in increased expression of ATP9A mRNA CTD PMID:18158353 NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818
JBrowse link
G Atxn1 ataxin 1 multiple interactions EXP Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]] CTD PMID:32278511 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 decreases expression EXP Phenylephrine results in decreased expression of AUTS2 mRNA CTD PMID:18158353
G Avp arginine vasopressin multiple interactions
increases secretion
EXP Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:2271928 PMID:11102496 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpi1 arginine vasopressin-induced 1 increases expression EXP Phenylephrine results in increased expression of AVPI1 mRNA CTD PMID:18158353 NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Phenylephrine results in increased expression of BAD protein CTD PMID:31605733 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression EXP Phenylephrine results in increased expression of BAMBI mRNA CTD PMID:18158353 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Phenylephrine results in decreased expression of BAX protein
Phenylephrine results in increased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]
CTD PMID:19910689 PMID:31605733 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions
increases phosphorylation
EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha decreases expression EXP Phenylephrine results in decreased expression of BCKDHA mRNA CTD PMID:18158353 NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
EXP
ISO
BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in decreased expression of BCL2 protein
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein
CTD PMID:11042672 PMID:19910689 PMID:31605733 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
EXP
ISO
Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein
CTD PMID:11042672 PMID:31605733 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 increases expression EXP Phenylephrine results in increased expression of BDH1 mRNA CTD PMID:18158353 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 decreases expression EXP Phenylephrine results in decreased expression of BDH2 mRNA CTD PMID:18158353 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance
increases expression
ISO
EXP
BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA
CTD PMID:10614985 PMID:18158353 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Phenylephrine results in increased expression of BDNF mRNA CTD PMID:18158353 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bmp7 bone morphogenetic protein 7 decreases expression EXP Phenylephrine results in decreased expression of BMP7 mRNA CTD PMID:18158353 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Phenylephrine results in increased expression of BNIP3L mRNA CTD PMID:16291751 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Boll boule homolog, RNA binding protein decreases expression EXP Phenylephrine results in decreased expression of BOLL mRNA CTD PMID:18158353 NCBI chr 9:56,734,890...56,859,917
Ensembl chr 9:56,733,584...56,859,916
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions
increases expression
EXP Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein
CTD PMID:23939492 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Btbd11 BTB domain containing 11 decreases expression EXP Phenylephrine results in decreased expression of BTBD11 mRNA CTD PMID:18158353 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression EXP Phenylephrine results in increased expression of BTG3 mRNA CTD PMID:18158353 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
JBrowse link
G Ca4 carbonic anhydrase 4 increases expression EXP Phenylephrine results in increased expression of CA4 protein CTD PMID:17124262 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
JBrowse link
G Cabin1 calcineurin binding protein 1 multiple interactions EXP CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein] CTD PMID:10655507 PMID:17060317 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357
JBrowse link
G Cadps calcium dependent secretion activator decreases expression EXP Phenylephrine results in decreased expression of CADPS mRNA CTD PMID:18158353 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance ISO
EXP
CALCA protein affects the susceptibility to Phenylephrine CTD PMID:11728430 PMID:18055875 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA CTD PMID:17250927 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression EXP Phenylephrine results in decreased expression of CAMK2A mRNA CTD PMID:18158353 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions EXP CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Phenylephrine results in decreased activity of CA1 protein CTD PMID:28800181 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
EXP
ISO
Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein
CTD PMID:17124262 PMID:28800181 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp2 caspase 2 affects activity ISO Phenylephrine affects the activity of CASP2 protein CTD PMID:31605733 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein
CTD PMID:11042672 PMID:31605733 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 affects activity ISO Phenylephrine affects the activity of CASP8 protein CTD PMID:31605733 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Phenylephrine results in increased activity of CASP9 protein CTD PMID:31605733 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] CTD PMID:11071898 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cat catalase multiple interactions
decreases expression
EXP CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein
CTD PMID:16513848 PMID:18171680 PMID:20886221 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine] CTD PMID:18178722 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cav3 caveolin 3 multiple interactions
decreases response to substance
affects localization
ISO
EXP
CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CAV3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of CAV3 protein
CTD PMID:12847114 PMID:19299911 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein
CTD PMID:15721863 PMID:15728586 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression EXP Phenylephrine results in increased expression of CCL27 mRNA CTD PMID:18158353 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein
CTD PMID:15117851 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein CTD PMID:15276029 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein] CTD PMID:12163013 PMID:15603588 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP Phenylephrine results in increased expression of CCND2 protein CTD PMID:12163013 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein] CTD PMID:12163013 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccnt1 cyclin T1 multiple interactions EXP Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein] CTD PMID:17459355 NCBI chr 7:129,687,146...129,718,082
Ensembl chr 7:129,691,209...129,717,871
JBrowse link
G Cd200 Cd200 molecule decreases expression EXP Phenylephrine results in decreased expression of CD200 mRNA CTD PMID:18158353 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Phenylephrine results in increased expression of CDH2 protein CTD PMID:17526999 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Phenylephrine results in increased expression of CDK2 protein CTD PMID:15603588 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Phenylephrine results in increased expression of CDK4 protein CTD PMID:15603588 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
increases stability
ISO
EXP
Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA
CTD PMID:10766810 PMID:15603588 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Phenylephrine results in increased expression of CDKN1B CTD PMID:15603588 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP Phenylephrine results in decreased expression of CEBPA mRNA CTD PMID:19443575 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP [Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein] CTD PMID:17596272 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Phenylephrine results in increased expression of CHCHD6 mRNA CTD PMID:18158353 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
JBrowse link
G Clic2 chloride intracellular channel 2 decreases expression EXP Phenylephrine results in decreased expression of CLIC2 mRNA CTD PMID:18158353 NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression EXP Phenylephrine results in increased expression of CLIC4 mRNA CTD PMID:18158353 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Clu clusterin increases expression EXP Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein CTD PMID:19443575 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cnn1 calponin 1 increases expression EXP Phenylephrine results in increased expression of CNN1 mRNA CTD PMID:18158353 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression EXP Phenylephrine results in decreased expression of COL18A1 mRNA CTD PMID:18158353 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Colec12 collectin sub-family member 12 decreases expression EXP Phenylephrine results in decreased expression of COLEC12 mRNA CTD PMID:18158353 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
JBrowse link
G Corin corin, serine peptidase increases expression EXP Phenylephrine results in increased expression of CORIN mRNA CTD PMID:15191894 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of COX11 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]
CTD PMID:23818984 PMID:25107896 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions
decreases expression
EXP Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein] CTD PMID:23818984 PMID:25107896 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression
multiple interactions
EXP Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]
CTD PMID:23818984 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
decreases expression
increases expression
EXP 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein
Phenylephrine results in increased expression of CPT1B mRNA
CTD PMID:11879187 PMID:15721863 PMID:19699196 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:14741741 PMID:15522277 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions
increases response to substance
EXP [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine
CTD PMID:11705990 PMID:12477714 PMID:15006641 PMID:15522277 PMID:19966502 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Phenylephrine results in increased expression of CREM mRNA CTD PMID:12791704 PMID:18158353 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crk CRK proto-oncogene, adaptor protein multiple interactions EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein] CTD PMID:17615370 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Phenylephrine results in decreased expression of CSNK2A1 mRNA CTD PMID:18158353 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 increases expression EXP Phenylephrine results in increased expression of CSPG4 mRNA CTD PMID:18158353 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Phenylephrine results in increased expression of CSRP2 mRNA CTD PMID:18158353 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases localization EXP Phenylephrine results in increased localization of CSRP3 protein CTD PMID:19376126 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
JBrowse link
G Cth cystathionine gamma-lyase increases activity EXP Phenylephrine results in increased activity of CTH protein CTD PMID:18184479 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter] CTD PMID:19799869 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsc cathepsin C decreases expression EXP Phenylephrine results in decreased expression of CTSC mRNA CTD PMID:18158353 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Phenylephrine results in decreased expression of CXCL1 mRNA CTD PMID:18158353 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Phenylephrine results in decreased expression of CXCL10 mRNA CTD PMID:18158353 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression EXP Phenylephrine results in decreased expression of CXCL11 mRNA CTD PMID:18158353 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression EXP Phenylephrine results in decreased expression of CXCL5 mRNA CTD PMID:18158353 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxxc4 CXXC finger protein 4 decreases expression EXP Phenylephrine results in decreased expression of CXXC4 mRNA CTD PMID:18158353 NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Phenylephrine results in increased expression of CYP11B2 mRNA CTD PMID:19966502 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 increases expression EXP Phenylephrine results in increased expression of CYP26B1 mRNA CTD PMID:18158353 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases response to substance
affects response to substance
EXP 20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine] CTD PMID:11124159 PMID:12388396 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Phenylephrine results in increased expression of CYP51 mRNA CTD PMID:18158353 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression EXP Phenylephrine results in decreased expression of DAPK1 mRNA CTD PMID:18158353 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dgke diacylglycerol kinase epsilon multiple interactions ISO DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein] CTD PMID:18487437 NCBI chr10:73,852,679...73,877,334
Ensembl chr10:73,855,583...73,877,100
JBrowse link
G Dgkz diacylglycerol kinase zeta multiple interactions ISO DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:16380548 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP Phenylephrine results in increased expression of DHCR7 mRNA CTD PMID:18158353 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases activity
increases expression
EXP Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA
CTD PMID:15345674 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dnah12 dynein, axonemal, heavy chain 12 decreases expression EXP Phenylephrine results in decreased expression of DNAH12 mRNA CTD PMID:18158353 NCBI chr16:1,936,354...2,092,663
Ensembl chr16:1,937,817...2,092,664
JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression EXP Phenylephrine results in increased expression of DNAJB5 mRNA CTD PMID:18158353 NCBI chr 5:57,176,840...57,185,492
Ensembl chr 5:57,176,845...57,185,490
JBrowse link
G Dnm1l dynamin 1-like increases expression
multiple interactions
EXP Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]
CTD PMID:20886221 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dpt dermatopontin decreases expression EXP Phenylephrine results in decreased expression of DPT mRNA CTD PMID:18158353 NCBI chr13:77,122,926...77,151,646
Ensembl chr13:77,123,115...77,151,639
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Phenylephrine results in increased expression of DUSP1 mRNA CTD PMID:18158353 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:15757502 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G E2f3 E2F transcription factor 3 increases expression EXP Phenylephrine results in increased expression of E2F3 protein CTD PMID:12682052 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G E2f4 E2F transcription factor 4 increases expression EXP Phenylephrine results in increased expression of E2F4 protein CTD PMID:12682052 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
JBrowse link
G E2f5 E2F transcription factor 5 increases expression EXP Phenylephrine results in increased expression of E2F5 protein CTD PMID:12682052 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Phenylephrine results in increased expression of ECE1 mRNA CTD PMID:15007106 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression EXP Phenylephrine results in increased expression of ECM1 mRNA CTD PMID:18158353 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
increases expression
affects response to substance
EXP MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
Phenylephrine results in increased expression of MBF1
MBF1 protein affects the susceptibility to Phenylephrine
CTD PMID:12729799 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases response to substance
increases expression
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein
CTD PMID:10788492 PMID:11739382 PMID:12724418 PMID:15007106 PMID:15220332 More... NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Phenylephrine results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein CTD PMID:16760267 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO
EXP
Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
Phenylephrine results in increased phosphorylation of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:14676212 PMID:16760267 PMID:18360054 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Phenylephrine results in increased expression of EGLN3 mRNA CTD PMID:18158353 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO
EXP
EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]
CTD PMID:7905536 PMID:10710348 PMID:10779383 PMID:15621046 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases phosphorylation
EXP CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein] CTD PMID:15757502 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases phosphorylation
EXP 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases expression
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein
CTD PMID:10900171 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 increases expression EXP Phenylephrine results in increased expression of ELOVL5 mRNA CTD PMID:18158353 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Eno2 enolase 2 increases expression EXP Phenylephrine results in increased expression of ENO2 mRNA CTD PMID:18158353 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Eno3 enolase 3 increases expression EXP Phenylephrine results in increased expression of ENO3 mRNA CTD PMID:18158353 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
increases expression
increases response to substance
ISO
EXP
EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
EP300 protein results in increased susceptibility to Phenylephrine
CTD PMID:11705990 PMID:12477714 PMID:12724418 PMID:15006641 PMID:15220332 More... NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,178,529
Ensembl chr 7:113,106,247...113,178,529
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Phenylephrine results in decreased expression of EPAS1 mRNA CTD PMID:18158353 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epb41l4b erythrocyte membrane protein band 4.1 like 4B increases expression EXP Phenylephrine results in increased expression of EPB41L4B mRNA CTD PMID:18158353 NCBI chr 5:71,691,706...71,852,039
Ensembl chr 5:71,694,331...71,851,990
JBrowse link
G Epha4 Eph receptor A4 decreases expression EXP Phenylephrine results in decreased expression of EPHA4 mRNA CTD PMID:18158353 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Phenylephrine results in decreased expression of EPHX2 mRNA CTD PMID:18158353 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine] CTD PMID:17158209 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 multiple interactions EXP EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:17327491 NCBI chr 3:154,335,558...154,519,006
Ensembl chr 3:154,335,400...154,518,793
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression EXP Phenylephrine results in decreased expression of FABP4 mRNA CTD PMID:18158353 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fads3 fatty acid desaturase 3 increases expression EXP Phenylephrine results in increased expression of FADS3 mRNA CTD PMID:18158353 NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
JBrowse link
G Fam110b family with sequence similarity 110, member B decreases expression EXP Phenylephrine results in decreased expression of FAM110B mRNA CTD PMID:18158353 NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828
JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine] CTD PMID:17641673 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fdx1 ferredoxin 1 increases expression EXP Phenylephrine results in increased expression of FDX1 mRNA CTD PMID:18158353 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
JBrowse link
G Fgf12 fibroblast growth factor 12 increases expression EXP Phenylephrine results in increased expression of FGF12 mRNA CTD PMID:18158353 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Fgf18 fibroblast growth factor 18 increases expression EXP Phenylephrine results in increased expression of FGF18 mRNA CTD PMID:18158353 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter] CTD PMID:10779383 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Phenylephrine results in increased expression of FHL1 mRNA CTD PMID:18158353 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases response to substance EXP FHL2 gene mutant form results in decreased susceptibility to Phenylephrine CTD PMID:25358972 NCBI chr 9:45,388,979...45,462,530
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions
EXP Phenylephrine results in increased expression of FIS1 protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]
CTD PMID:20886221 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression
EXP FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein
CTD PMID:19542178 PMID:2490