Gja5 (gap junction protein, alpha 5) - Rat Genome Database

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Gene: Gja5 (gap junction protein, alpha 5) Mus musculus
Analyze
Symbol: Gja5
Name: gap junction protein, alpha 5
RGD ID: 736165
MGI Page MGI
Description: Enables gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling. Involved in artery morphogenesis; cell communication by electrical coupling involved in cardiac conduction; and regulation of cardiac muscle cell action potential. Acts upstream of or within several processes, including cardiac conduction; circulatory system development; and regulation of systemic arterial blood pressure. Located in gap junction. Is expressed in several structures, including cardiovascular system; early conceptus; limb mesenchyme; musculature; and skin. Used to study tetralogy of Fallot. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730555N10Rik; Cnx40; connexin 40; connexin i; connexin-40; Cx40; Cxni; gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; Gja-; Gja-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)EnsemblGRCm39 Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBIMGSCv36mm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
artery morphogenesis  (IMP)
atrial cardiac muscle cell to AV node cell communication by electrical coupling  (IBA,IMP,ISO)
atrial septum development  (ISO)
atrial septum morphogenesis  (IMP)
atrial ventricular junction remodeling  (IMP)
AV node cell to bundle of His cell communication  (IMP)
AV node cell to bundle of His cell communication by electrical coupling  (IMP,ISO)
blood vessel development  (IMP)
blood vessel diameter maintenance  (IMP)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IMP,ISO)
cardiac conduction  (IMP)
cardiac conduction system development  (IMP)
cell communication  (IEA)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (ISO)
cell communication by electrical coupling involved in cardiac conduction  (IMP,ISO)
cell communication involved in cardiac conduction  (IMP)
cell-cell signaling  (IBA)
cellular response to platelet-derived growth factor stimulus  (ISO)
embryonic heart tube development  (IMP)
embryonic limb morphogenesis  (IMP)
endothelium development  (ISO)
foramen ovale closure  (IMP)
gap junction assembly  (ISO)
heart development  (IBA,ISO)
mitral valve development  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of glomerular filtration  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of vasoconstriction  (ISO)
potassium ion transport  (ISO)
pulmonary valve formation  (ISO)
regulation of atrial cardiac muscle cell action potential  (ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (IMP,ISO)
regulation of AV node cell action potential  (IMP,ISO)
regulation of bundle of His cell action potential  (IMP,ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart rate by cardiac conduction  (IMP)
regulation of membrane depolarization during cardiac muscle cell action potential  (IMP)
regulation of Purkinje myocyte action potential  (ISO)
regulation of renin secretion into blood stream  (IMP)
regulation of systemic arterial blood pressure  (IMP)
regulation of ventricular cardiac muscle cell membrane depolarization  (IGI,IMP)
regulation of ventricular cardiac muscle cell membrane repolarization  (IGI,IMP)
renal system process involved in regulation of systemic arterial blood pressure  (IMP)
SA node cell action potential  (IMP)
septum primum development  (IMP)
skeletal system development  (IMP)
vasodilation  (ISO)
vasomotion  (ISO)
ventricular cardiac muscle cell action potential  (IMP)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal frontal plane axis  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal heart morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal QRS complex  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal testis morphology  (IAGP)
alveolitis  (IAGP)
bifid atrial appendage  (IAGP)
blood vessel congestion  (IAGP)
bundle branch block  (IAGP)
common atrioventricular valve  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
dilated cardiomyopathy  (IAGP)
double outlet right ventricle  (IAGP)
fragmented QRS complex  (IAGP)
gastrointestinal hemorrhage  (IAGP)
increased circulating renin level  (IAGP)
increased heart rate  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to injury  (IAGP)
increased vasodilation  (IAGP)
irregular heartbeat  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lung hemorrhage  (IAGP)
mitral valve stenosis  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ostium primum atrial septal defect  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
prolonged P wave  (IAGP)
prolonged PQ interval  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged QT interval  (IAGP)
pulmonary artery hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cerebrovascular connexin expression: effects of traumatic brain injury. Avila MA, etal., J Neurotrauma. 2011 Sep;28(9):1803-11. doi: 10.1089/neu.2011.1900. Epub 2011 Sep 6.
2. Connexins: gaps in our knowledge of vascular function. Figueroa XF, etal., Physiology (Bethesda). 2004 Oct;19:277-84.
3. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. Gollob MH, etal., N Engl J Med. 2006 Jun 22;354(25):2677-88.
4. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
5. Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. Haefliger JA, etal., Kidney Int. 2001 Jul;60(1):190-201.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Changes of gap junctional cell-cell communication in overactive detrusor in rats. Li L, etal., Am J Physiol Cell Physiol. 2007 Nov;293(5):C1627-35. Epub 2007 Sep 13.
8. Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization. Ludwig T, etal., J Biol Chem 1992 Jun 15;267(17):12211-9.
9. Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Ma J, etal., Biomed Pharmacother. 2018 Apr;100:156-167. doi: 10.1016/j.biopha.2018.02.013. Epub 2018 Feb 8.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats. Ming J, etal., Shock. 2009 Jan;31(1):80-6. doi: 10.1097/SHK.0b013e31817d3eF2-11.
14. Glomerular expression of connexin 40 and connexin 43 in rat experimental glomerulonephritis. Morioka T, etal., Clin Exp Nephrol. 2012 Sep 4.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. Polontchouk L, etal., J Am Coll Cardiol. 2001 Sep;38(3):883-91.
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium. Rignault S, etal., Crit Care Med. 2005 Jun;33(6):1302-10.
21. Decreased endothelial size and connexin expression in rat caudal arteries during hypertension. Rummery NM, etal., J Hypertens. 2002 Feb;20(2):247-53.
22. Mouse connexin40: gene structure and promoter analysis. Seul KH, etal., Genomics 1997 Nov 15;46(1):120-6.
23. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
24. Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Soemedi R, etal., Hum Mol Genet. 2012 Apr 1;21(7):1513-20. doi: 10.1093/hmg/ddr589. Epub 2011 Dec 22.
25. Study of the mechanism of antihypertensive peptides VPP and IPP in spontaneously hypertensive rats by DNA microarray analysis. Yamaguchi N, etal., Eur J Pharmacol. 2009 Oct 12;620(1-3):71-7. doi: 10.1016/j.ejphar.2009.08.005. Epub 2009 Aug 14.
26. Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat. Young EJ, etal., Diabetologia. 2008 May;51(5):872-81. doi: 10.1007/s00125-008-0934-y. Epub 2008 Mar 7.
27. NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats. Zheng YF, etal., J Pharm Pharmacol. 2010 May;62(5):615-21. doi: 10.1211/jpp/62.05.0009.
Additional References at PubMed
PMID:1318884   PMID:1332196   PMID:1666038   PMID:1964417   PMID:7771689   PMID:7835895   PMID:7889986   PMID:8223273   PMID:8288218   PMID:8404042   PMID:8601030   PMID:8631157  
PMID:8660976   PMID:8834803   PMID:8970160   PMID:9285645   PMID:9486664   PMID:9501069   PMID:9501070   PMID:9508777   PMID:9570965   PMID:9861669   PMID:10079513   PMID:10086977  
PMID:10099690   PMID:10196667   PMID:10349636   PMID:10515563   PMID:10636196   PMID:10747000   PMID:10751663   PMID:10903175   PMID:10926765   PMID:10931824   PMID:10969038   PMID:10996788  
PMID:11007485   PMID:11042159   PMID:11046183   PMID:11073890   PMID:11076861   PMID:11083248   PMID:11397787   PMID:11455436   PMID:11572777   PMID:11922902   PMID:11967204   PMID:12011587  
PMID:12023302   PMID:12064615   PMID:12435353   PMID:12466851   PMID:12477932   PMID:12502569   PMID:12522123   PMID:12619874   PMID:12637364   PMID:12697838   PMID:12700362   PMID:12842919  
PMID:12923887   PMID:12956325   PMID:14595769   PMID:14627725   PMID:14630724   PMID:14681012   PMID:14681045   PMID:14732399   PMID:15037532   PMID:15042700   PMID:15081111   PMID:15085192  
PMID:15158141   PMID:15184386   PMID:15194464   PMID:15255617   PMID:15289437   PMID:15297379   PMID:15459098   PMID:15466892   PMID:15489334   PMID:15576406   PMID:15676282   PMID:15721864  
PMID:15743826   PMID:15843414   PMID:15850572   PMID:15895417   PMID:15901664   PMID:15923624   PMID:15977181   PMID:16037099   PMID:16100040   PMID:16105048   PMID:16107612   PMID:16141072  
PMID:16141073   PMID:16145663   PMID:16203908   PMID:16203917   PMID:16284228   PMID:16314491   PMID:16380715   PMID:16505993   PMID:16530167   PMID:16648291   PMID:16677630   PMID:16709898  
PMID:16870172   PMID:16919680   PMID:16985003   PMID:17050624   PMID:17053190   PMID:17062627   PMID:17122196   PMID:17149706   PMID:17220177   PMID:17234970   PMID:17255527   PMID:17259303  
PMID:17332425   PMID:17372176   PMID:17417650   PMID:17468400   PMID:17473172   PMID:17482496   PMID:17483738   PMID:17546509   PMID:17609378   PMID:17622273   PMID:17640036   PMID:17823370  
PMID:17855490   PMID:17932322   PMID:18178574   PMID:18256189   PMID:18285513   PMID:18345009   PMID:18401004   PMID:18463230   PMID:18467625   PMID:18470945   PMID:18482576   PMID:18521823  
PMID:18550715   PMID:18583714   PMID:18599871   PMID:18662696   PMID:18723448   PMID:18787025   PMID:18790841   PMID:18812700   PMID:18816853   PMID:19073828   PMID:19096026   PMID:19109587  
PMID:19151513   PMID:19166829   PMID:19248787   PMID:19255801   PMID:19429814   PMID:19443640   PMID:19443641   PMID:19474190   PMID:19486903   PMID:19592579   PMID:19672618   PMID:19679680  
PMID:19726871   PMID:19820254   PMID:19855129   PMID:20026782   PMID:20095052   PMID:20110337   PMID:20139090   PMID:20185795   PMID:20360386   PMID:20427707   PMID:20530546   PMID:20541007  
PMID:20651287   PMID:20686449   PMID:20802140   PMID:20818502   PMID:20929948   PMID:21239638   PMID:21266775   PMID:21267068   PMID:21272575   PMID:21304516   PMID:21344610   PMID:21350214  
PMID:21396893   PMID:21447555   PMID:21515254   PMID:21597036   PMID:21640717   PMID:21641379   PMID:21757651   PMID:21793101   PMID:21825130   PMID:21873635   PMID:21983003   PMID:21986401  
PMID:22076636   PMID:22116619   PMID:22130515   PMID:22203979   PMID:22307665   PMID:22411556   PMID:22513384   PMID:22622036   PMID:22647876   PMID:22719074   PMID:22723296   PMID:22739121  
PMID:22783020   PMID:22811484   PMID:22898775   PMID:22992950   PMID:23090768   PMID:23093775   PMID:23255421   PMID:23292716   PMID:23303406   PMID:23314057   PMID:23395391   PMID:23407022  
PMID:23426374   PMID:23440962   PMID:23445620   PMID:23471232   PMID:23526457   PMID:23529931   PMID:23533173   PMID:23542581   PMID:23603510   PMID:23690951   PMID:23743334   PMID:23840823  
PMID:24060583   PMID:24096827   PMID:24131868   PMID:24143284   PMID:24285498   PMID:24310815   PMID:24486905   PMID:24550118   PMID:24563458   PMID:24614215   PMID:24639196   PMID:24764455  
PMID:24937433   PMID:25050930   PMID:25144323   PMID:25229336   PMID:25241776   PMID:25269082   PMID:25336743   PMID:25369777   PMID:25482882   PMID:25488669   PMID:25545736   PMID:25547341  
PMID:25599332   PMID:25613430   PMID:25690864   PMID:25712722   PMID:25802403   PMID:25834185   PMID:26138475   PMID:26193633   PMID:26198171   PMID:26204914   PMID:26253403   PMID:26321050  
PMID:26378152   PMID:26398496   PMID:26550940   PMID:26553930   PMID:26641715   PMID:26654778   PMID:26708418   PMID:26786475   PMID:26821948   PMID:26876178   PMID:26883111   PMID:26897025  
PMID:26897459   PMID:26953188   PMID:27056912   PMID:27166947   PMID:27169737   PMID:27172058   PMID:27180262   PMID:27194161   PMID:27217161   PMID:27250245   PMID:27580238   PMID:27775552  
PMID:27789228   PMID:27880905   PMID:27930960   PMID:27997827   PMID:28122731   PMID:28124622   PMID:28179430   PMID:28195173   PMID:28302382   PMID:28527294   PMID:28538179   PMID:28724790  
PMID:28732025   PMID:28924218   PMID:28931948   PMID:28982669   PMID:29371594   PMID:29427253   PMID:29540665   PMID:29743679   PMID:29773646   PMID:29859889   PMID:29979676   PMID:30042181  
PMID:30234377   PMID:30347193   PMID:30596653   PMID:30718617   PMID:30745457   PMID:30765799   PMID:30787001   PMID:30936179   PMID:30936836   PMID:31202927   PMID:31284824   PMID:31286141  
PMID:31306714   PMID:31320323   PMID:31366290   PMID:31434798   PMID:31688894   PMID:31778152   PMID:31789590   PMID:31836710   PMID:32212902   PMID:32242217   PMID:32251422   PMID:32383994  
PMID:32672536   PMID:32675240   PMID:32687896   PMID:32883967   PMID:33082351   PMID:33299176   PMID:33454003   PMID:33706307   PMID:33898448   PMID:34100064   PMID:34198942   PMID:34506481  
PMID:34618403   PMID:34747371   PMID:35019839   PMID:35079138   PMID:35105870   PMID:35126469   PMID:35297995   PMID:35388219   PMID:35951416   PMID:36142603   PMID:36239312   PMID:36400745  
PMID:36877136   PMID:37002228   PMID:38014633   PMID:38235330   PMID:38349880  


Genomics

Comparative Map Data
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)EnsemblGRCm39 Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBIMGSCv36mm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,756,199 - 147,773,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
T2T-CHM13v2.01147,034,309 - 147,051,468 (+)NCBIT2T-CHM13v2.0
Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,285,495 - 59,302,023 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBIUU_Cfam_GSD_1.0
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,813,011 - 16,814,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gja5
596 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:826
Count of miRNA genes:512
Interacting mature miRNAs:605
Transcripts:ENSMUST00000072600, ENSMUST00000132256
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse

Markers in Region
PMC203028P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38397,050,966 - 97,051,500UniSTSGRCm38
MGSCv37396,854,889 - 96,855,423UniSTSGRCm37
Celera398,458,160 - 98,458,694UniSTS
Cytogenetic Map3F2.1UniSTS
Gja5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38397,050,629 - 97,050,883UniSTSGRCm38
MGSCv37396,854,552 - 96,854,806UniSTSGRCm37
Celera398,457,823 - 98,458,077UniSTS
Cytogenetic Map3F2.1UniSTS
cM Map345.6UniSTS
Gja5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.1UniSTS
cM Map345.6UniSTS
Gja5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000072600   ⟹   ENSMUSP00000088264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,939,732 - 96,960,950 (+)Ensembl
GRCm38.p6 Ensembl397,032,416 - 97,053,634 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132256   ⟹   ENSMUSP00000123582
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,939,732 - 96,958,189 (+)Ensembl
GRCm38.p6 Ensembl397,032,416 - 97,050,873 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199597   ⟹   ENSMUSP00000143542
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,812,009 - 96,984,732 (+)Ensembl
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)Ensembl
RefSeq Acc Id: NM_001271628   ⟹   NP_001258557
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,939,718 - 96,960,950 (+)NCBI
GRCm38397,032,402 - 97,053,634 (+)NCBI
Celera398,439,593 - 98,460,828 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008121   ⟹   NP_032147
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,939,718 - 96,960,950 (+)NCBI
GRCm38397,032,402 - 97,053,634 (+)NCBI
MGSCv37396,836,339 - 96,857,557 (+)RGD
Celera398,439,593 - 98,460,828 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032147   ⟸   NM_008121
- UniProtKB: Q01231 (UniProtKB/Swiss-Prot),   A0A654ICB8 (UniProtKB/TrEMBL),   Q8CAG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258557   ⟸   NM_001271628
- UniProtKB: Q01231 (UniProtKB/Swiss-Prot),   A0A654ICB8 (UniProtKB/TrEMBL),   Q8CAG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000143542   ⟸   ENSMUST00000199597
RefSeq Acc Id: ENSMUSP00000123582   ⟸   ENSMUST00000132256
RefSeq Acc Id: ENSMUSP00000088264   ⟸   ENSMUST00000072600
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01231-F1-model_v2 AlphaFold Q01231 1-358 view protein structure

Promoters
RGD ID:6833829
Promoter ID:MM_KWN:35432
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_008121,   UC008QOO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,836,191 - 96,836,691 (+)MPROMDB
RGD ID:6849133
Promoter ID:MM_XEF:4667
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001017442,   NM_001078022,   NM_181703,   NM_205504
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,854,571 - 96,855,071 (+)MPROMDB
RGD ID:6881732
Promoter ID:EPDNEW_M4317
Type:initiation region
Name:Gja5_1
Description:Mus musculus gap junction protein, alpha 5 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38397,032,402 - 97,032,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95716 AgrOrtholog
Ensembl Genes ENSMUSG00000057123 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072600 ENTREZGENE
  ENSMUST00000072600.7 UniProtKB/Swiss-Prot
  ENSMUST00000132256.8 UniProtKB/TrEMBL
  ENSMUST00000199597.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cx40_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95716 ENTREZGENE
NCBI Gene 14613 ENTREZGENE
PANTHER PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin40_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GJA5 RGD
PhenoGen Gja5 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINA5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF118220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A654ICB8 ENTREZGENE, UniProtKB/TrEMBL
  CXA5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6TPI9_MOUSE UniProtKB/TrEMBL
  Q8CAG8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Gja5  gap junction protein, alpha 5  Gja5  gap junction membrane channel protein alpha 5  Symbol and/or name change 5135510 APPROVED