Tgfbr1 (transforming growth factor, beta receptor I) - Rat Genome Database

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Gene: Tgfbr1 (transforming growth factor, beta receptor I) Mus musculus
Analyze
Symbol: Tgfbr1
Name: transforming growth factor, beta receptor I
RGD ID: 736083
MGI Page MGI
Description: Enables several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including epicardium morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and collagen fibril organization. Located in endosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Loeys-Dietz syndrome; head and neck squamous cell carcinoma; and osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); colorectal cancer; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AL; Alk; Alk-5; ALK5; AU017191; ESK2; Tbet; Tbeta; TbetaR-I; TbetaRI; TGF-beta receptor type I; TGF-beta receptor type-1; TGFR-1; transforming growth factor-beta receptor type I
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39447,353,258 - 47,414,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm39 Ensembl
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBIMGSCv36mm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Animal Disease Models  (ISO)
aortic aneurysm  (ISO)
aortic disease  (ISO)
Carotid Artery Injuries  (ISO)
Charlevoix-Saguenay spastic ataxia  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital disorder of glycosylation Ii  (ISO)
congenital disorder of glycosylation type II  (ISO)
congenital myasthenic syndrome 14  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
diffuse scleroderma  (ISO)
Disproportionate Tall Stature  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Experimental Liver Cirrhosis  (IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
Familial Thoracic Aortic Aneurysm 6  (ISO)
Ferguson-Smith tumor  (ISO)
Hyperalgesia  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Loeys-Dietz syndrome  (IAGP,ISO)
Loeys-Dietz syndrome 1  (ISO)
Lynch syndrome  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
myocardial infarction  (ISO)
myoepithelioma  (ISO)
Neoplasm Metastasis  (ISO)
nephronophthisis  (ISO)
osteoarthritis  (IAGP)
osteochondrodysplasia  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (ISO)
Skin Neoplasms  (ISO)
Spontaneous Abortions  (ISO)
systemic scleroderma  (IAGP)
thoracic aortic aneurysm  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3'-diindolylmethane  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitrophenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl alcohol  (ISO)
alpha-pinene  (ISO)
AM-251  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
bellidifolin  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (EXP)
Cinobufagin  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocin-1  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP)
diazepam  (ISO)
dichlorine  (ISO)
dimethylarsinic acid  (EXP)
enalapril  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furosemide  (ISO)
galangin  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
hydrogen cyanide  (EXP)
inulin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
Isoangustone A  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
lenalidomide  (ISO)
leupeptin  (ISO)
lignan  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
LY-2157299  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oxalic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
patulin  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
Phyllanthin  (EXP)
piperine  (ISO)
potassium chromate  (ISO)
prostaglandin E2  (EXP)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salvianolic acid B  (ISO)
SB 431542  (EXP,ISO)
silicon dioxide  (EXP,ISO)
Sinomenine  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetramethylpyrazine  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
tolfenamic acid  (ISO)
tranilast  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA)
angiogenesis  (IMP)
angiogenesis involved in coronary vascular morphogenesis  (IMP)
animal organ regeneration  (ISO)
anterior/posterior pattern specification  (IGI)
apoptotic process  (IMP)
artery morphogenesis  (IMP)
blastocyst development  (IDA)
cell differentiation  (IEA)
cell motility  (ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cellular response to growth factor stimulus  (IBA)
cellular response to transforming growth factor beta stimulus  (IDA,ISO)
collagen fibril organization  (IMP)
coronary artery morphogenesis  (IMP)
digestive tract development  (ISO)
embryo implantation  (ISO)
embryonic cranial skeleton morphogenesis  (IMP)
endothelial cell migration  (IMP)
endothelial cell proliferation  (IGI)
epicardium morphogenesis  (IMP)
epithelial to mesenchymal transition  (ISO)
filopodium assembly  (IMP)
germ cell migration  (IMP)
heart development  (IBA,IMP)
in utero embryonic development  (IMP)
kidney development  (IGI)
lens development in camera-type eye  (IMP)
lung development  (ISO)
male gonad development  (IMP)
myofibroblast differentiation  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell migration  (ISO)
negative regulation of chondrocyte differentiation  (IMP)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell proliferation  (IGI)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of miRNA transcription  (ISO)
nervous system development  (IBA)
neuron fate commitment  (IMP)
parathyroid gland development  (IMP)
pharyngeal system development  (IMP)
positive regulation of apoptotic process  (IDA)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (IGI)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of filopodium assembly  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of mesenchymal stem cell proliferation  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of stress fiber assembly  (IGI)
positive regulation of tight junction disassembly  (IGI)
positive regulation of vasculature development  (ISO)
post-embryonic development  (IMP)
proepicardium development  (IMP)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of cardiac muscle cell proliferation  (IMP)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (IMP)
regulation of protein ubiquitination  (ISO)
response to cholesterol  (IDA,ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to organic cyclic compound  (ISO)
response to prostaglandin E  (ISO)
response to toxic substance  (ISO)
roof of mouth development  (IGI,IMP)
signal transduction  (ISO)
skeletal system development  (IGI)
skeletal system morphogenesis  (IGI)
SMAD protein signal transduction  (ISO)
thymus development  (IMP)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IGI,IMP,ISO)
ventricular compact myocardium morphogenesis  (IMP)
ventricular septum morphogenesis  (IMP)
ventricular trabecula myocardium morphogenesis  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anal canal morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal aorta bulb morphology  (IAGP)
abnormal aorta elastic fiber morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal bronchiole epithelium morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal medial nasal prominence morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal palatal shelf morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal skin development  (IAGP)
abnormal synovial joint morphology  (IAGP)
abnormal type IV hypersensitivity reaction  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent vitelline blood vessels  (IAGP)
aortic dissection  (IAGP)
ascending aorta aneurysm  (IAGP)
bilateral cleft upper lip  (IAGP)
cleft upper lip  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased club cell number  (IAGP)
decreased dendritic cell number  (IAGP)
decreased embryo size  (IAGP)
decreased gland tumor incidence  (IAGP)
dilated aorta bulb  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated respiratory conducting tube  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enhanced wound healing  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
hemopericardium  (IAGP)
hemothorax  (IAGP)
increased aorta wall thickness  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cell proliferation  (IAGP)
increased chondrocyte apoptosis  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased hematopoietic stem cell proliferation  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased oral papilloma incidence  (IAGP)
increased organ/body region tumor incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
kinked neural tube  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
maxillary prominence hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoarthritis  (IAGP)
osteophytes  (IAGP)
palatal shelf hypoplasia  (IAGP)
pericardial effusion  (IAGP)
premature coronal suture closure  (IAGP)
premature cranial suture closure  (IAGP)
premature death  (IAGP)
premature lambdoid suture closure  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small lung  (IAGP)
unilateral cleft upper lip  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
2. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. Asano Y, etal., J Clin Invest. 2004 Jan;113(2):253-64.
3. A transforming growth factor beta type I receptor that signals to activate gene expression. Bassing CH, etal., Science 1994 Jan 7;263(5143):87-9.
4. Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34.
5. Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer. Chen T, etal., Clin Cancer Res. 2006 Jan 15;12(2):392-7.
6. An intronic variant of the TGFBR1 gene is associated with carcinomas of the kidney and bladder. Chen T, etal., Int J Cancer. 2004 Nov 10;112(3):420-5.
7. Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. Chen Y, etal., Am J Pathol. 2005 Dec;167(6):1699-711.
8. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. de Gouville AC, etal., Br J Pharmacol. 2005 May;145(2):166-77.
9. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
10. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
11. Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. Hao J, etal., J Mol Cell Cardiol. 1999 Mar;31(3):667-78.
12. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
13. Transforming growth factor beta type I receptor acts as a potent tumor suppressor in rat bladder carcinoma. Hattori K, etal., Carcinogenesis. 1997 Oct;18(10):1867-70.
14. TGFBR1*6A polymorphism in sporadic and familial colorectal Carcinoma: a case-control study and systematic literature review. Ibrahim T, etal., J Gastrointest Cancer. 2014 Dec;45(4):441-7. doi: 10.1007/s12029-014-9625-8.
15. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis. Khalil N, etal., Exp Lung Res. 2002 Apr-May;28(3):233-50.
18. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
19. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Laping NJ, etal., Clin Cancer Res. 2007 May 15;13(10):3087-99.
20. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Loeys BL, etal., Nat Genet. 2005 Mar;37(3):275-81. Epub 2005 Jan 30.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function. Schniewind B, etal., Oncogene. 2007 Jul 19;26(33):4850-62. doi: 10.1038/sj.onc.1210272. Epub 2007 Feb 12.
33. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
34. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Siegel PM, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8430-5. Epub 2003 Jun 13.
35. [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis] Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
36. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
37. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
38. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
39. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
40. Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension. Zaiman AL, etal., Am J Respir Crit Care Med. 2008 Apr 15;177(8):896-905. Epub 2008 Jan 17.
41. Acute Effects of Transforming Growth Factor-β1 on Neuronal Excitability and Involvement in the Pain of Rats with Chronic Pancreatitis. Zhang X, etal., J Neurogastroenterol Motil. 2016 Apr 30;22(2):333-43. doi: 10.5056/jnm15127.
42. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Zhang Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Dec;27(12):1094-8.
Additional References at PubMed
PMID:7641785   PMID:7813789   PMID:8117261   PMID:8117262   PMID:8140412   PMID:8268187   PMID:8605036   PMID:8883836   PMID:9434964   PMID:9449696   PMID:9856985   PMID:9879710  
PMID:9921650   PMID:10030593   PMID:10349636   PMID:10433915   PMID:10521784   PMID:10885742   PMID:10949049   PMID:11042159   PMID:11076861   PMID:11285230   PMID:11544199   PMID:11641223  
PMID:11675471   PMID:11850179   PMID:12047746   PMID:12070302   PMID:12391023   PMID:12477932   PMID:12520002   PMID:12546816   PMID:12588999   PMID:12666204   PMID:12773577   PMID:12838410  
PMID:12842983   PMID:14580334   PMID:14610273   PMID:14681479   PMID:14729481   PMID:14764882   PMID:14996829   PMID:15142957   PMID:15239668   PMID:15247277   PMID:15342483   PMID:15350225  
PMID:15376321   PMID:15459394   PMID:15489334   PMID:15548578   PMID:15657037   PMID:15744664   PMID:15761148   PMID:15761153   PMID:15769904   PMID:15820682   PMID:15850837   PMID:15963767  
PMID:15976303   PMID:15993878   PMID:16075367   PMID:16141072   PMID:16141073   PMID:16344855   PMID:16601693   PMID:16602821   PMID:16806156   PMID:16845371   PMID:17071858   PMID:17078885  
PMID:17126294   PMID:17168649   PMID:17197570   PMID:17274978   PMID:17418116   PMID:17530030   PMID:17530708   PMID:17534148   PMID:17634193   PMID:17657819   PMID:17673906   PMID:17878231  
PMID:17911384   PMID:17977532   PMID:18005957   PMID:18029401   PMID:18095342   PMID:18243111   PMID:18252868   PMID:18257072   PMID:18287559   PMID:18310502   PMID:18316594   PMID:18337748  
PMID:18438410   PMID:18469808   PMID:18474439   PMID:18474728   PMID:18572160   PMID:18586087   PMID:18625725   PMID:18676816   PMID:18718461   PMID:18796535   PMID:18804439   PMID:18821589  
PMID:18832392   PMID:18945958   PMID:18990706   PMID:19096363   PMID:19147584   PMID:19165826   PMID:19398875   PMID:19398960   PMID:19462458   PMID:19494318   PMID:19501582   PMID:19520971  
PMID:19531477   PMID:19538749   PMID:19556242   PMID:19561097   PMID:19580641   PMID:19584284   PMID:19619490   PMID:19653094   PMID:19679673   PMID:19757385   PMID:19951995   PMID:20042635  
PMID:20147383   PMID:20171187   PMID:20207738   PMID:20346356   PMID:20436479   PMID:20471380   PMID:20572855   PMID:20603020   PMID:20607716   PMID:20713882   PMID:20962846   PMID:21062784  
PMID:21127043   PMID:21131965   PMID:21266196   PMID:21267068   PMID:21282335   PMID:21297643   PMID:21402782   PMID:21491542   PMID:21518866   PMID:21530805   PMID:21537080   PMID:21593423  
PMID:21604321   PMID:21731673   PMID:21832243   PMID:21841138   PMID:21852401   PMID:21873635   PMID:21876535   PMID:21947380   PMID:21984393   PMID:21998450   PMID:22028666   PMID:22037217  
PMID:22202673   PMID:22326956   PMID:22388934   PMID:22399812   PMID:22451679   PMID:22485132   PMID:22498737   PMID:22560297   PMID:22584670   PMID:22706160   PMID:22773947   PMID:22859719  
PMID:23065670   PMID:23103542   PMID:23213481   PMID:23248173   PMID:23307286   PMID:23340180   PMID:23342175   PMID:23546880   PMID:23562608   PMID:23565059   PMID:23624079   PMID:23661518  
PMID:23712751   PMID:23770676   PMID:23770987   PMID:23831617   PMID:23868260   PMID:23918385   PMID:23946447   PMID:23950180   PMID:24088962   PMID:24089514   PMID:24124460   PMID:24127404  
PMID:24279395   PMID:24319055   PMID:24324142   PMID:24344132   PMID:24347165   PMID:24355923   PMID:24474796   PMID:24506537   PMID:24515103   PMID:24573206   PMID:24587008   PMID:24590287  
PMID:24760528   PMID:24817606   PMID:24835278   PMID:24859004   PMID:24859199   PMID:24906954   PMID:24912677   PMID:24952961   PMID:25002492   PMID:25065622   PMID:25204661   PMID:25266657  
PMID:25382630   PMID:25398982   PMID:25406396   PMID:25421310   PMID:25429440   PMID:25456500   PMID:25467979   PMID:25505200   PMID:25720380   PMID:25722190   PMID:25723392   PMID:25759071  
PMID:25849774   PMID:25885904   PMID:26053644   PMID:26081042   PMID:26120030   PMID:26138667   PMID:26138704   PMID:26151572   PMID:26202810   PMID:26305969   PMID:26322481   PMID:26418219  
PMID:26496610   PMID:26657345   PMID:26680585   PMID:26692002   PMID:26980767   PMID:26984772   PMID:27020852   PMID:27180663   PMID:27224923   PMID:27235139   PMID:27318131   PMID:27344183  
PMID:27418101   PMID:27453501   PMID:27573189   PMID:27739498   PMID:27798955   PMID:27824055   PMID:27826032   PMID:27866969   PMID:27892604   PMID:27923978   PMID:27997889   PMID:28095798  
PMID:28145440   PMID:28168444   PMID:28368414   PMID:28423340   PMID:28518142   PMID:28622298   PMID:28657664   PMID:28662367   PMID:28716756   PMID:28747781   PMID:28759052   PMID:28811219  
PMID:28845554   PMID:28924218   PMID:28931816   PMID:28945245   PMID:29031500   PMID:29047105   PMID:29190781   PMID:29343501   PMID:29440304   PMID:29456135   PMID:29572483   PMID:29588073  
PMID:29788434   PMID:29846864   PMID:30078186   PMID:30100246   PMID:30111642   PMID:30230540   PMID:30459156   PMID:30655341   PMID:30660362   PMID:30718289   PMID:30929801   PMID:31023188  
PMID:31071011   PMID:31142541   PMID:31144525   PMID:31173246   PMID:31177814   PMID:31273920   PMID:31311317   PMID:31311865   PMID:31400222   PMID:31402170   PMID:31437169   PMID:31506281  
PMID:31526760   PMID:31647983   PMID:31845233   PMID:31845891   PMID:32001436   PMID:32065217   PMID:32274860   PMID:32319652   PMID:32404924   PMID:32531799   PMID:32535034   PMID:32597756  
PMID:32849598   PMID:32901868   PMID:32902612   PMID:32938678   PMID:33227706   PMID:33302058   PMID:33328221   PMID:33367515   PMID:33452687   PMID:33808650   PMID:33914044   PMID:33927274  
PMID:34103493   PMID:34228237   PMID:34273276   PMID:34321999   PMID:34359856   PMID:34385332   PMID:34440873   PMID:34452925   PMID:34456753   PMID:34625532   PMID:35236825   PMID:35323108  
PMID:35385750   PMID:35894043   PMID:35920128   PMID:35931031   PMID:36099022   PMID:36263050   PMID:36463362   PMID:36477656   PMID:36496409   PMID:36517604   PMID:36542062   PMID:36594096  
PMID:36608150   PMID:36751050   PMID:36762637   PMID:36787190   PMID:37419106   PMID:37641479   PMID:37702066   PMID:37931653   PMID:37940068   PMID:38007853   PMID:38217856   PMID:38328944  
PMID:38509075  


Genomics

Comparative Map Data
Tgfbr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39447,353,258 - 47,414,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm39 Ensembl
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBIMGSCv36mm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
TGFBR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,103,647 - 99,154,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,104,038 - 99,154,192 (+)EnsemblGRCh38hg38GRCh38
GRCh379101,867,395 - 101,916,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,907,233 - 100,956,295 (+)NCBINCBI36Build 36hg18NCBI36
Build 34998,946,966 - 98,991,862NCBI
Celera972,381,280 - 72,430,335 (+)NCBICelera
Cytogenetic Map9q22.33NCBI
HuRef971,464,684 - 71,515,132 (+)NCBIHuRef
CHM1_19102,013,851 - 102,062,916 (+)NCBICHM1_1
T2T-CHM13v2.09111,275,348 - 111,325,904 (+)NCBIT2T-CHM13v2.0
Tgfbr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8566,449,348 - 66,506,371 (+)NCBIGRCr8
mRatBN7.2561,653,773 - 61,710,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl561,653,233 - 61,710,777 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx563,625,637 - 63,682,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0565,444,934 - 65,502,017 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0565,414,409 - 65,471,481 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,056,071 - 63,119,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,050,758 - 63,119,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0567,575,578 - 67,643,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0569,079,391 - 69,097,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,976,868 - 64,034,058 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1563,981,949 - 64,034,967 (+)NCBI
Celera565,882,184 - 65,907,477 (-)NCBICelera
Cytogenetic Map5q22NCBI
Tgfbr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541926,490,899 - 26,547,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,490,899 - 26,546,349 (-)NCBIChiLan1.0ChiLan1.0
TGFBR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21140,304,045 - 40,352,561 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1940,306,377 - 40,354,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0970,195,007 - 70,243,514 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1998,337,417 - 98,362,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl998,332,739 - 98,362,748 (+)Ensemblpanpan1.1panPan2
TGFBR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,191,383 - 56,223,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,161,772 - 56,218,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1154,594,299 - 54,654,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01157,272,690 - 57,331,474 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1157,272,651 - 57,331,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11155,775,923 - 55,835,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01155,800,862 - 55,860,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01156,499,979 - 56,559,879 (+)NCBIUU_Cfam_GSD_1.0
Tgfbr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,109,141 - 171,133,324 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365247,655,847 - 7,681,097 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365247,656,523 - 7,680,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,860,156 - 240,918,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,842,735 - 240,918,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,090,577 - 269,149,183 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11240,272,507 - 40,321,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1240,276,916 - 40,297,372 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660352,236,283 - 2,258,310 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,839,178 - 1,899,156 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248251,773,158 - 1,899,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbr1
1124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2244
Count of miRNA genes:716
Interacting mature miRNAs:927
Transcripts:ENSMUST00000007757, ENSMUST00000044234, ENSMUST00000107725, ENSMUST00000123962, ENSMUST00000126171
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1558794Agnm1_mautoimmune glomerulonephritis in MRL 1 (mouse)Not determined44633264655755867Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
13432179Acq1_mactivity chamber QTL 1 (mouse)44708712850187128Mouse

Markers in Region
AU017191  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38447,383,892 - 47,384,019UniSTSGRCm38
MGSCv37447,396,764 - 47,396,891UniSTSGRCm37
Celera447,406,359 - 47,406,486UniSTS
Cytogenetic Map4B1UniSTS
cM Map419.3UniSTS
Whitehead/MRC_RH4743.27UniSTS
D25540  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38447,411,304 - 47,411,433UniSTSGRCm38
MGSCv37447,424,176 - 47,424,305UniSTSGRCm37
Celera447,433,753 - 47,433,882UniSTS
Cytogenetic Map4B1UniSTS
cM Map419.3UniSTS
Whitehead/MRC_RH4744.2UniSTS
Tgfbr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37447,424,507 - 47,424,710UniSTSGRCm37
MGSCv37447,418,406 - 47,418,509UniSTSGRCm37
Celera447,427,983 - 47,428,086UniSTS
Celera447,434,084 - 47,434,287UniSTS
Cytogenetic Map4B1UniSTS
cM Map419.3UniSTS
cM Map419.3UniSTS
38.MMHAP32FLE5.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38447,355,801 - 47,355,969UniSTSGRCm38
MGSCv37447,368,673 - 47,368,841UniSTSGRCm37
Celera447,378,263 - 47,378,431UniSTS
Cytogenetic Map4B1UniSTS
cM Map419.3UniSTS
Whitehead_YAC4 UniSTS
PMC145465P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38447,392,934 - 47,393,084UniSTSGRCm38
MGSCv37447,405,806 - 47,405,956UniSTSGRCm37
Celera447,415,403 - 47,415,553UniSTS
Cytogenetic Map4B1UniSTS
cM Map419.3UniSTS
Tgfbr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38447,411,635 - 47,411,838UniSTSGRCm38
MGSCv37447,424,507 - 47,424,710UniSTSGRCm37
Celera447,434,084 - 47,434,287UniSTS
Cytogenetic Map4B1UniSTS
cM Map419.3UniSTS
Tgfbr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38447,405,534 - 47,405,637UniSTSGRCm38
MGSCv37447,418,406 - 47,418,509UniSTSGRCm37
Celera447,427,983 - 47,428,086UniSTS
Cytogenetic Map4B1UniSTS
Tgfbr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B1UniSTS
Tgfbr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001312868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001312869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK007125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL772232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY200044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK637995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D25540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB746001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000007757   ⟹   ENSMUSP00000007757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl447,353,222 - 47,414,931 (+)Ensembl
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)Ensembl
RefSeq Acc Id: ENSMUST00000044234   ⟹   ENSMUSP00000048501
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl447,353,307 - 47,412,133 (+)Ensembl
GRCm38.p6 Ensembl447,353,307 - 47,412,133 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107725   ⟹   ENSMUSP00000103353
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl447,386,216 - 47,411,035 (+)Ensembl
GRCm38.p6 Ensembl447,386,216 - 47,411,035 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123962
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl447,353,598 - 47,361,313 (+)Ensembl
GRCm38.p6 Ensembl447,353,598 - 47,361,313 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126171   ⟹   ENSMUSP00000123761
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl447,353,610 - 47,410,807 (+)Ensembl
GRCm38.p6 Ensembl447,353,610 - 47,410,807 (+)Ensembl
RefSeq Acc Id: NM_001312868   ⟹   NP_001299797
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,353,258 - 47,414,924 (+)NCBI
GRCm38447,353,222 - 47,414,924 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001312869   ⟹   NP_001299798
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,386,235 - 47,414,924 (+)NCBI
GRCm38447,386,216 - 47,414,924 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001424886   ⟹   NP_001411815
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,353,258 - 47,414,924 (+)NCBI
RefSeq Acc Id: NM_001424887   ⟹   NP_001411816
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,353,258 - 47,414,924 (+)NCBI
RefSeq Acc Id: NM_001424888   ⟹   NP_001411817
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,386,235 - 47,414,924 (+)NCBI
RefSeq Acc Id: NM_001424889   ⟹   NP_001411818
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,353,258 - 47,414,924 (+)NCBI
RefSeq Acc Id: NM_009370   ⟹   NP_033396
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,353,258 - 47,414,924 (+)NCBI
GRCm38447,353,222 - 47,414,924 (+)NCBI
MGSCv37447,366,177 - 47,427,796 (+)RGD
Celera447,375,763 - 47,437,373 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036163955   ⟹   XP_036019848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39447,353,599 - 47,414,926 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033396   ⟸   NM_009370
- Peptide Label: isoform 1 precursor
- UniProtKB: A2AJN0 (UniProtKB/Swiss-Prot),   Q64729 (UniProtKB/Swiss-Prot),   Q4FJL1 (UniProtKB/TrEMBL),   E9Q418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001299797   ⟸   NM_001312868
- Peptide Label: isoform 2 precursor
- UniProtKB: E9Q418 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001299798   ⟸   NM_001312869
- Peptide Label: isoform 3
- UniProtKB: Q9D5H8 (UniProtKB/TrEMBL),   Q3U485 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000007757   ⟸   ENSMUST00000007757
RefSeq Acc Id: ENSMUSP00000103353   ⟸   ENSMUST00000107725
RefSeq Acc Id: ENSMUSP00000123761   ⟸   ENSMUST00000126171
RefSeq Acc Id: ENSMUSP00000048501   ⟸   ENSMUST00000044234
RefSeq Acc Id: XP_036019848   ⟸   XM_036163955
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001411815   ⟸   NM_001424886
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001411816   ⟸   NM_001424887
- Peptide Label: isoform 5 precursor
RefSeq Acc Id: NP_001411818   ⟸   NM_001424889
- Peptide Label: isoform 7 precursor
RefSeq Acc Id: NP_001411817   ⟸   NM_001424888
- Peptide Label: isoform 6
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64729-F1-model_v2 AlphaFold Q64729 1-503 view protein structure

Promoters
RGD ID:6883376
Promoter ID:EPDNEW_M5139
Type:initiation region
Name:Tgfbr1_1
Description:Mus musculus transforming growth factor, beta receptor I , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38447,353,291 - 47,353,351EPDNEW
RGD ID:6836501
Promoter ID:MM_KWN:37549
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000015672,   OTTMUST00000015675,   OTTMUST00000015676,   UC008SUO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36447,365,676 - 47,366,217 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98728 AgrOrtholog
Ensembl Genes ENSMUSG00000007613 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000007757 ENTREZGENE
  ENSMUST00000007757.15 UniProtKB/Swiss-Prot
  ENSMUST00000044234 ENTREZGENE
  ENSMUST00000044234.14 UniProtKB/Swiss-Prot
  ENSMUST00000107725 ENTREZGENE
  ENSMUST00000107725.3 UniProtKB/TrEMBL
  ENSMUST00000126171.9 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21812 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98728 ENTREZGENE
NCBI Gene 21812 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-BETA RECEPTOR TYPE-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfbr1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AJN0 ENTREZGENE
  E9Q418 ENTREZGENE, UniProtKB/TrEMBL
  Q3U485 ENTREZGENE, UniProtKB/TrEMBL
  Q4FJL1 ENTREZGENE, UniProtKB/TrEMBL
  Q64729 ENTREZGENE
  Q9CVP4_MOUSE UniProtKB/TrEMBL
  Q9D5H8 ENTREZGENE, UniProtKB/TrEMBL
  TGFR1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2AJN0 UniProtKB/Swiss-Prot