Tgfbr1 (transforming growth factor beta receptor 1) - Rat Genome Database

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Gene: Tgfbr1 (transforming growth factor beta receptor 1) Ictidomys tridecemlineatus
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Symbol: Tgfbr1
Name: transforming growth factor beta receptor 1
RGD ID: 12704629
Description: ENCODES a protein that exhibits ATP binding (ortholog); growth factor binding (ortholog); I-SMAD binding (ortholog); INVOLVED IN activation of MAPKK activity (ortholog); aging (ortholog); angiogenesis (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; glypican signaling pathway; ASSOCIATED WITH Animal Disease Models (ortholog); aortic disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: TGF-beta receptor type-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,109,141 - 171,133,324 (+)NCBI
SpeTri2.0NW_0049365247,656,523 - 7,680,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO)
aging  (ISO)
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
animal organ regeneration  (ISO)
anterior/posterior pattern specification  (ISO)
artery morphogenesis  (ISO)
blastocyst development  (ISO)
cell motility  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen fibril organization  (ISO)
coronary artery morphogenesis  (ISO)
digestive tract development  (ISO)
embryo implantation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
endothelial cell migration  (ISO)
epicardium morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO)
germ cell migration  (ISO)
heart development  (ISO)
in utero embryonic development  (ISO)
kidney development  (ISO)
lens development in camera-type eye  (ISO)
lung development  (ISO)
male gonad development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
neuron fate commitment  (ISO)
parathyroid gland development  (ISO)
pathway-restricted SMAD protein phosphorylation  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
pharyngeal system development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular component movement  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of tight junction disassembly  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
post-embryonic development  (ISO)
proepicardium development  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of protein binding  (ISO)
regulation of protein ubiquitination  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cholesterol  (ISO)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to organic cyclic compound  (ISO)
response to prostaglandin E  (ISO)
response to toxic substance  (ISO)
roof of mouth development  (ISO)
signal transduction  (ISO)
skeletal system development  (ISO)
skeletal system morphogenesis  (ISO)
thymus development  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Tgfbr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,109,141 - 171,133,324 (+)NCBI
SpeTri2.0NW_0049365247,656,523 - 7,680,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl999,104,038 - 99,154,192 (+)EnsemblGRCh38hg38GRCh38
GRCh38999,104,038 - 99,154,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379101,867,395 - 101,916,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,907,233 - 100,956,295 (+)NCBINCBI36hg18NCBI36
Build 34998,946,966 - 98,991,862NCBI
Celera972,381,280 - 72,430,335 (+)NCBI
Cytogenetic Map9q22.33NCBI
HuRef971,464,684 - 71,515,132 (+)NCBIHuRef
CHM1_19102,013,810 - 102,062,916 (+)NCBICHM1_1
Tgfbr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39447,353,222 - 47,414,926 (+)NCBIGRCm39mm39
GRCm39 Ensembl447,353,222 - 47,414,931 (+)Ensembl
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBImm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
Tgfbr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2561,653,773 - 61,710,777 (+)NCBI
Rnor_6.0 Ensembl563,050,758 - 63,119,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0563,056,071 - 63,119,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0569,079,391 - 69,097,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0567,575,578 - 67,643,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,976,868 - 64,034,058 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1563,981,949 - 64,034,967 (+)NCBI
Celera565,882,184 - 65,907,477 (-)NCBICelera
Cytogenetic Map5q22NCBI
Tgfbr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541926,490,899 - 26,547,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,490,899 - 26,546,349 (-)NCBIChiLan1.0ChiLan1.0
TGFBR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1998,337,417 - 98,362,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl998,332,739 - 98,362,748 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0970,195,007 - 70,243,514 (+)NCBIMhudiblu_PPA_v0panPan3
TGFBR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,191,383 - 56,223,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,161,772 - 56,218,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1154,594,299 - 54,654,173 (+)NCBI
ROS_Cfam_1.01157,272,690 - 57,331,474 (+)NCBI
UMICH_Zoey_3.11155,775,923 - 55,835,949 (+)NCBI
UNSW_CanFamBas_1.01155,800,862 - 55,860,799 (+)NCBI
UU_Cfam_GSD_1.01156,499,979 - 56,559,879 (+)NCBI
TGFBR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,859,270 - 240,918,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,842,735 - 240,918,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,090,577 - 269,149,183 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11240,272,507 - 40,321,740 (-)NCBI
ChlSab1.1 Ensembl1240,276,916 - 40,297,372 (-)Ensembl
Vero_WHO_p1.0NW_0236660352,236,283 - 2,258,310 (+)NCBI
Tgfbr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248251,773,158 - 1,899,120 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013359089   ⟹   XP_013214543
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947171,109,142 - 171,133,324 (+)NCBI
SpeTri2.0NW_0049365247,656,523 - 7,680,043 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040286092   ⟹   XP_040142026
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947171,109,141 - 171,133,324 (+)NCBI
Protein Sequences
Protein RefSeqs XP_013214543 (Get FASTA)   NCBI Sequence Viewer  
  XP_040142026 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013214543   ⟸   XM_013359089
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040142026   ⟸   XM_040286092
- Peptide Label: isoform X1
Protein Domains
GS   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013570 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000012159 UniProtKB/TrEMBL
  ENSSTOP00000026532 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000028382 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013570 UniProtKB/TrEMBL
  ENSSTOT00000031197 UniProtKB/TrEMBL
  ENSSTOT00000040801 UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/TrEMBL
  GS_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
NCBI Gene Tgfbr1 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS51256 UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
  SM00467 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287CYZ5_ICTTR UniProtKB/TrEMBL
  A0A287D4D4_ICTTR UniProtKB/TrEMBL
  I3ML93_ICTTR UniProtKB/TrEMBL