TGFBR1 (transforming growth factor beta receptor 1) - Rat Genome Database

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Gene: TGFBR1 (transforming growth factor beta receptor 1) Homo sapiens
Symbol: TGFBR1
Name: transforming growth factor beta receptor 1
RGD ID: 733386
Description: Enables several functions, including ATP binding activity; I-SMAD binding activity; and transforming growth factor beta receptor activity, type I. Contributes to transforming growth factor beta binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein phosphorylation. Located in several cellular components, including bicellular tight junction; endosome; and membrane raft. Part of receptor complex. Implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; multiple self-healing squamous epithelioma; mutant transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; TBR-i; TBRI; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); transforming growth factor-beta receptor type I
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100421483  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl999,104,038 - 99,154,192 (+)EnsemblGRCh38hg38GRCh38
GRCh38999,104,038 - 99,154,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379101,867,395 - 101,916,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,907,233 - 100,956,295 (+)NCBINCBI36hg18NCBI36
Build 34998,946,966 - 98,991,862NCBI
Celera972,381,280 - 72,430,335 (+)NCBI
Cytogenetic Map9q22.33NCBI
HuRef971,464,684 - 71,515,132 (+)NCBIHuRef
CHM1_19102,013,851 - 102,062,916 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3'-diindolylmethane  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acrolein  (EXP)
acteoside  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allyl alcohol  (ISO)
alpha-pinene  (EXP)
AM-251  (EXP)
ammonium chloride  (ISO)
anthocyanin  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (ISO)
bleomycin A2  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calciol  (ISO)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (ISO)
cisatracurium  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
crocin-1  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
diazepam  (EXP)
dichlorine  (ISO)
dimethylarsinic acid  (ISO)
enalapril  (ISO)
Enterolactone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
flutamide  (ISO)
formaldehyde  (EXP)
furosemide  (ISO)
galangin  (EXP)
glafenine  (ISO)
glucose  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (EXP)
hexachlorobenzene  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
Isoangustone A  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lenalidomide  (EXP)
leupeptin  (ISO)
lignan  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
Methylazoxymethanol acetate  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
mifepristone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
nitrofen  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
oxalic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
paraquat  (ISO)
Pentoxifylline  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
piperine  (EXP)
potassium chromate  (EXP)
prostaglandin E2  (ISO)
quartz  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salvianolic acid B  (ISO)
SB 431542  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
tolfenamic acid  (EXP)
triadimefon  (ISO)
trichostatin A  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,ISS)
aging  (ISO)
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISS)
animal organ regeneration  (ISO)
anterior/posterior pattern specification  (ISO,ISS)
apoptotic process  (IEA)
artery morphogenesis  (ISO,ISS)
blastocyst development  (IEA,ISO)
cardiac epithelial to mesenchymal transition  (ISS)
cell motility  (IMP)
cellular response to growth factor stimulus  (IBA)
cellular response to transforming growth factor beta stimulus  (IDA)
collagen fibril organization  (ISO,ISS)
coronary artery morphogenesis  (ISS)
digestive tract development  (ISO)
embryo implantation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO,ISS)
endothelial cell activation  (ISS)
endothelial cell migration  (IEA,ISO)
epicardium morphogenesis  (ISS)
epithelial to mesenchymal transition  (IDA)
extracellular structure organization  (TAS)
germ cell migration  (ISO,ISS)
heart development  (IBA,ISO,ISS)
in utero embryonic development  (ISO,ISS)
intracellular signal transduction  (ISS)
kidney development  (ISO,ISS)
lens development in camera-type eye  (IEA,ISO)
lung development  (ISO)
male gonad development  (IEA,ISO)
mesenchymal cell differentiation  (ISS,TAS)
negative regulation of apoptotic process  (ISO)
negative regulation of chondrocyte differentiation  (ISS)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IMP)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
nervous system development  (IBA)
neuron fate commitment  (ISO,ISS)
parathyroid gland development  (ISO,ISS)
pathway-restricted SMAD protein phosphorylation  (IDA)
peptidyl-serine phosphorylation  (IDA)
peptidyl-threonine phosphorylation  (IDA)
pharyngeal system development  (ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IDA)
positive regulation of cell growth  (IDA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IMP)
positive regulation of cellular component movement  (IMP)
positive regulation of endothelial cell proliferation  (ISS)
positive regulation of epithelial to mesenchymal transition  (ISS)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISS)
positive regulation of filopodium assembly  (IEA,ISO)
positive regulation of gene expression  (IMP,ISS)
positive regulation of MAPK cascade  (IDA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IDA)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of SMAD protein signal transduction  (IDA)
positive regulation of stress fiber assembly  (ISS)
positive regulation of tight junction disassembly  (ISS)
positive regulation of transcription, DNA-templated  (IDA,ISS)
post-embryonic development  (IEA,ISO)
proepicardium development  (ISS)
protein autophosphorylation  (ISO)
protein phosphorylation  (IBA,IDA,IEA,ISO)
regulation of cardiac muscle cell proliferation  (ISS)
regulation of cell cycle  (TAS)
regulation of epithelial to mesenchymal transition  (ISS)
regulation of gene expression  (ISO,ISS)
regulation of protein binding  (IEA,ISO)
regulation of protein ubiquitination  (IDA)
regulation of transcription, DNA-templated  (IDA,IMP)
response to cholesterol  (IDA)
response to electrical stimulus  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to organic cyclic compound  (ISO)
response to prostaglandin E  (ISO)
response to toxic substance  (ISO)
roof of mouth development  (ISO,ISS)
signal transduction  (IDA)
skeletal system development  (ISO,ISS)
skeletal system morphogenesis  (ISO,ISS)
thymus development  (ISO,ISS)
transforming growth factor beta receptor signaling pathway  (IBA,IC,IDA,IMP,ISO,ISS)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IEA)
ventricular compact myocardium morphogenesis  (ISS)
ventricular septum morphogenesis  (ISS)
ventricular trabecula myocardium morphogenesis  (ISS)
wound healing  (TAS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal aortic aneurysm  (IAGP)
Abnormal left ventricular function  (IAGP)
Abnormal sternum morphology  (IAGP)
Abnormality iris morphology  (IAGP)
Abnormality of the skin  (IAGP)
Aortic aneurysm  (IAGP)
Aortic dissection  (IAGP)
Aortic regurgitation  (IAGP)
Aortic root aneurysm  (IAGP)
Arachnodactyly  (IAGP)
Arnold-Chiari malformation  (IAGP)
Arterial dissection  (IAGP)
Arterial tortuosity  (IAGP)
Ascending aortic dissection  (IAGP)
Atrial septal defect  (IAGP)
Atypical scarring of skin  (IAGP)
Autosomal dominant inheritance  (IAGP)
Bicuspid aortic valve  (IAGP)
Bifid uvula  (IAGP)
Blue sclerae  (IAGP)
Bruising susceptibility  (IAGP)
Camptodactyly  (IAGP)
Camptodactyly of finger  (IAGP)
Cardiac arrest  (IAGP)
Cardiomegaly  (IAGP)
Carotid artery dilatation  (IAGP)
Cervical spine instability  (IAGP)
Chest pain  (IAGP)
Coronary artery atherosclerosis  (IAGP)
Craniosynostosis  (IAGP)
Cutis marmorata  (IAGP)
Dermal translucency  (IAGP)
Descending aortic dissection  (IAGP)
Descending thoracic aorta aneurysm  (IAGP)
Dilatation of the cerebral artery  (IAGP)
Disproportionate tall stature  (IAGP)
Dural ectasia  (IAGP)
Eosinophilic infiltration of the esophagus  (IAGP)
Exertional dyspnea  (IAGP)
Exotropia  (IAGP)
Global developmental delay  (IAGP)
Hemoptysis  (IAGP)
High palate  (IAGP)
High, narrow palate  (IAGP)
Hydrocephalus  (IAGP)
Hypertelorism  (IAGP)
Hypertension  (IAGP)
Hypovolemia  (IAGP)
Inguinal hernia  (IAGP)
Intellectual disability  (IAGP)
Ischemic stroke  (IAGP)
Joint dislocation  (IAGP)
Joint hyperflexibility  (IAGP)
Joint laxity  (IAGP)
Malar flattening  (IAGP)
Micrognathia  (IAGP)
Mitral valve prolapse  (IAGP)
Mucoid extracellular matrix accumulation  (IAGP)
Neoplasm  (IAGP)
Onset  (IAGP)
Paroxysmal dyspnea  (IAGP)
Patent ductus arteriosus  (IAGP)
Pectus carinatum  (IAGP)
Pectus excavatum  (IAGP)
Peripheral arterial stenosis  (IAGP)
Pes planus  (IAGP)
Pneumothorax  (IAGP)
Postaxial hand polydactyly  (IAGP)
Prenatal maternal abnormality  (IAGP)
Proptosis  (IAGP)
Pulmonary artery aneurysm  (IAGP)
Retrognathia  (IAGP)
Scoliosis  (IAGP)
Soft skin  (IAGP)
Striae distensae  (IAGP)
Subarachnoid hemorrhage  (IAGP)
Talipes equinovarus  (IAGP)
Tall stature  (IAGP)
Thin skin  (IAGP)
Transient ischemic attack  (IAGP)
Uterine rupture  (IAGP)

References - curated
1. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
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3. Bassing CH, etal., Science 1994 Jan 7;263(5143):87-9.
4. Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34.
5. Chen T, etal., Clin Cancer Res. 2006 Jan 15;12(2):392-7.
6. Chen T, etal., Int J Cancer. 2004 Nov 10;112(3):420-5.
7. Chen Y, etal., Am J Pathol. 2005 Dec;167(6):1699-711.
8. de Gouville AC, etal., Br J Pharmacol. 2005 May;145(2):166-77.
9. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
10. GOA_HUMAN data from the GO Consortium
11. Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
12. Hao J, etal., J Mol Cell Cardiol. 1999 Mar;31(3):667-78.
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15. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
16. Khalil N, etal., Exp Lung Res. 2002 Apr-May;28(3):233-50.
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18. Loeys BL, etal., Nat Genet. 2005 Mar;37(3):275-81. Epub 2005 Jan 30.
19. OMIM Disease Annotation Pipeline
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
26. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
27. Siegel PM, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8430-5. Epub 2003 Jun 13.
28. Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
29. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
30. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
31. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
32. Zaiman AL, etal., Am J Respir Crit Care Med. 2008 Apr 15;177(8):896-905. Epub 2008 Jan 17.
33. Zhang X, etal., J Neurogastroenterol Motil. 2016 Apr 30;22(2):333-43. doi: 10.5056/jnm15127.
34. Zhang Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Dec;27(12):1094-8.
Additional References at PubMed
PMID:1319842   PMID:1326540   PMID:1333888   PMID:7518616   PMID:7774578   PMID:7791754   PMID:7852346   PMID:7890683   PMID:8235612   PMID:8242742   PMID:8242743   PMID:8521960  
PMID:8530052   PMID:8530343   PMID:8555189   PMID:8576253   PMID:8622651   PMID:8752209   PMID:8774881   PMID:8980228   PMID:9045666   PMID:9136927   PMID:9215638   PMID:9311995  
PMID:9335505   PMID:9335507   PMID:9346894   PMID:9346908   PMID:9389648   PMID:9417915   PMID:9435577   PMID:9436979   PMID:9439661   PMID:9472030   PMID:9525694   PMID:9545258  
PMID:9661882   PMID:9738003   PMID:9748228   PMID:9759503   PMID:9774674   PMID:9856985   PMID:9865696   PMID:9872992   PMID:9892009   PMID:10025408   PMID:10085121   PMID:10716993  
PMID:10757800   PMID:11100470   PMID:11102446   PMID:11157754   PMID:11163210   PMID:11278251   PMID:11278302   PMID:11279102   PMID:11356828   PMID:11387212   PMID:11420127   PMID:11438668  
PMID:11483955   PMID:11583628   PMID:11746979   PMID:11820800   PMID:11850637   PMID:11867510   PMID:12000714   PMID:12015308   PMID:12017275   PMID:12065756   PMID:12082094   PMID:12145287  
PMID:12151385   PMID:12202987   PMID:12358857   PMID:12429842   PMID:12446693   PMID:12477932   PMID:12543979   PMID:12607775   PMID:12857866   PMID:12873459   PMID:12947057   PMID:14517293  
PMID:14580334   PMID:14597484   PMID:14633705   PMID:14657019   PMID:14702039   PMID:14718519   PMID:15009106   PMID:15146427   PMID:15148321   PMID:15155736   PMID:15177479   PMID:15178549  
PMID:15247277   PMID:15305380   PMID:15317461   PMID:15350225   PMID:15356634   PMID:15359284   PMID:15385056   PMID:15459392   PMID:15465036   PMID:15496141   PMID:15498571   PMID:15505640  
PMID:15546867   PMID:15597342   PMID:15599934   PMID:15611116   PMID:15657037   PMID:15661740   PMID:15702480   PMID:15761148   PMID:15761153   PMID:15833881   PMID:15860866   PMID:15863158  
PMID:15938776   PMID:15946939   PMID:15955593   PMID:15961557   PMID:16027725   PMID:16049346   PMID:16170343   PMID:16289162   PMID:16407286   PMID:16528739   PMID:16596670   PMID:16754747  
PMID:16791849   PMID:16806156   PMID:16835936   PMID:16857807   PMID:16928994   PMID:16947635   PMID:16950395   PMID:16980081   PMID:16998703   PMID:17072348   PMID:17087113   PMID:17099224  
PMID:17203972   PMID:17238135   PMID:17314099   PMID:17319955   PMID:17365852   PMID:17507611   PMID:17575241   PMID:17607123   PMID:17649947   PMID:17652900   PMID:17657819   PMID:17703412  
PMID:17705854   PMID:17845732   PMID:17848193   PMID:17848956   PMID:17878231   PMID:17890272   PMID:17936924   PMID:18095342   PMID:18097622   PMID:18174230   PMID:18174246   PMID:18202754  
PMID:18223258   PMID:18243111   PMID:18252868   PMID:18316594   PMID:18333754   PMID:18421475   PMID:18456797   PMID:18469808   PMID:18474728   PMID:18511908   PMID:18541723   PMID:18546940  
PMID:18550062   PMID:18591668   PMID:18625725   PMID:18676680   PMID:18683732   PMID:18703712   PMID:18711258   PMID:18721526   PMID:18758450   PMID:18778720   PMID:18781618   PMID:18922473  
PMID:18925687   PMID:18974388   PMID:18978678   PMID:19004027   PMID:19012493   PMID:19036501   PMID:19116361   PMID:19139564   PMID:19147499   PMID:19170196   PMID:19214138   PMID:19229971  
PMID:19255252   PMID:19258923   PMID:19293232   PMID:19299112   PMID:19299629   PMID:19322201   PMID:19336370   PMID:19375841   PMID:19390964   PMID:19401691   PMID:19426152   PMID:19453261  
PMID:19494318   PMID:19505916   PMID:19506300   PMID:19509225   PMID:19538729   PMID:19542084   PMID:19556242   PMID:19586667   PMID:19592635   PMID:19595713   PMID:19601999   PMID:19608716  
PMID:19625176   PMID:19626999   PMID:19639490   PMID:19639654   PMID:19672284   PMID:19688145   PMID:19690145   PMID:19692168   PMID:19711426   PMID:19732720   PMID:19736306   PMID:19758997  
PMID:19863607   PMID:19882361   PMID:19883511   PMID:19908237   PMID:19913121   PMID:19916025   PMID:19930569   PMID:19936899   PMID:19995547   PMID:19998449   PMID:20052600   PMID:20086175  
PMID:20101143   PMID:20101206   PMID:20301299   PMID:20301312   PMID:20354825   PMID:20368424   PMID:20379614   PMID:20403997   PMID:20427239   PMID:20428796   PMID:20429896   PMID:20437058  
PMID:20445748   PMID:20453000   PMID:20458730   PMID:20500843   PMID:20503287   PMID:20538960   PMID:20571025   PMID:20587546   PMID:20599261   PMID:20628086   PMID:20634891   PMID:20662850  
PMID:20663871   PMID:20675371   PMID:20705955   PMID:20734064   PMID:20856203   PMID:20924066   PMID:20959473   PMID:21030067   PMID:21068203   PMID:21127043   PMID:21170488   PMID:21172820  
PMID:21186301   PMID:21224855   PMID:21225232   PMID:21295082   PMID:21304536   PMID:21358634   PMID:21423151   PMID:21429769   PMID:21441952   PMID:21465483   PMID:21478266   PMID:21539622  
PMID:21629263   PMID:21677877   PMID:21751154   PMID:21785915   PMID:21791611   PMID:21815248   PMID:21821041   PMID:21858550   PMID:21873635   PMID:21924348   PMID:21962132   PMID:21978186  
PMID:22006998   PMID:22015652   PMID:22078045   PMID:22087763   PMID:22088447   PMID:22096025   PMID:22100658   PMID:22136666   PMID:22278155   PMID:22290546   PMID:22292045   PMID:22314103  
PMID:22344298   PMID:22414221   PMID:22473997   PMID:22496417   PMID:22532183   PMID:22610405   PMID:22617150   PMID:22624557   PMID:22651914   PMID:22706160   PMID:22739178   PMID:22773947  
PMID:22803051   PMID:22848678   PMID:22905183   PMID:22911926   PMID:23027871   PMID:23064961   PMID:23166821   PMID:23349840   PMID:23358096   PMID:23455636   PMID:23548068   PMID:23624079  
PMID:23723426   PMID:23734265   PMID:23788249   PMID:23832740   PMID:23874384   PMID:23899993   PMID:23973329   PMID:24103590   PMID:24243761   PMID:24263861   PMID:24279395   PMID:24333532  
PMID:24344132   PMID:24344637   PMID:24347165   PMID:24367547   PMID:24399296   PMID:24512448   PMID:24551192   PMID:24558198   PMID:24658140   PMID:24747516   PMID:24771066   PMID:24793577  
PMID:24816588   PMID:24850914   PMID:24860093   PMID:24880985   PMID:24939309   PMID:24954139   PMID:24978044   PMID:24981199   PMID:25110237   PMID:25134534   PMID:25149540   PMID:25169976  
PMID:25173755   PMID:25273091   PMID:25502482   PMID:25544563   PMID:25622187   PMID:25715477   PMID:25825445   PMID:25826292   PMID:25872870   PMID:25882708   PMID:25893292   PMID:25998683  
PMID:26037400   PMID:26074400   PMID:26150340   PMID:26152726   PMID:26165686   PMID:26169354   PMID:26187313   PMID:26357964   PMID:26472812   PMID:26496610   PMID:26542979   PMID:26548632  
PMID:26583147   PMID:26583432   PMID:26616150   PMID:26620926   PMID:26652004   PMID:26679521   PMID:26720610   PMID:26766164   PMID:26807171   PMID:26872091   PMID:27048361   PMID:27105506  
PMID:27112580   PMID:27162619   PMID:27171242   PMID:27234654   PMID:27248167   PMID:27292796   PMID:27445263   PMID:27508510   PMID:27527810   PMID:27543359   PMID:27764818   PMID:27835901  
PMID:27879313   PMID:27885255   PMID:28146434   PMID:28277133   PMID:28373289   PMID:28489883   PMID:28518142   PMID:28522256   PMID:28574613   PMID:28625921   PMID:28632033   PMID:28633389  
PMID:28815607   PMID:28847661   PMID:28981109   PMID:29117863   PMID:29183791   PMID:29208458   PMID:29235674   PMID:29274137   PMID:29490279   PMID:29507755   PMID:29531222   PMID:29543232  
PMID:29568061   PMID:29572483   PMID:29662646   PMID:29706644   PMID:29735548   PMID:29742433   PMID:29971498   PMID:30032656   PMID:30115383   PMID:30135214   PMID:30142896   PMID:30212788  
PMID:30219046   PMID:30232004   PMID:30335615   PMID:30387848   PMID:30496724   PMID:30513140   PMID:30655341   PMID:30667085   PMID:30710564   PMID:30745168   PMID:30804470   PMID:30836988  
PMID:30943320   PMID:30948511   PMID:30987013   PMID:31027492   PMID:31098894   PMID:31171625   PMID:31182152   PMID:31196201   PMID:31300967   PMID:31339433   PMID:31390053   PMID:31545407  
PMID:31545479   PMID:31581360   PMID:31582001   PMID:31614978   PMID:31651066   PMID:31676070   PMID:31676288   PMID:31746425   PMID:31831099   PMID:31878829   PMID:31985874   PMID:31996061  
PMID:32062130   PMID:32062451   PMID:32152251   PMID:32281291   PMID:32324847   PMID:32423083   PMID:32535034   PMID:32581266   PMID:32694731   PMID:32751693   PMID:32794622   PMID:32920014  
PMID:33052230   PMID:33062039   PMID:33144569   PMID:33157202   PMID:33342936   PMID:33408307   PMID:33436942   PMID:33508008   PMID:33570811   PMID:33731513   PMID:33845483   PMID:33964734  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl999,104,038 - 99,154,192 (+)EnsemblGRCh38hg38GRCh38
GRCh38999,104,038 - 99,154,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379101,867,395 - 101,916,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,907,233 - 100,956,295 (+)NCBINCBI36hg18NCBI36
Build 34998,946,966 - 98,991,862NCBI
Celera972,381,280 - 72,430,335 (+)NCBI
Cytogenetic Map9q22.33NCBI
HuRef971,464,684 - 71,515,132 (+)NCBIHuRef
CHM1_19102,013,851 - 102,062,916 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39447,353,222 - 47,414,926 (+)NCBIGRCm39mm39
GRCm39 Ensembl447,353,222 - 47,414,931 (+)Ensembl
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBImm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2561,653,773 - 61,710,777 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl561,653,233 - 61,710,777 (+)Ensembl
Rnor_6.0563,056,071 - 63,119,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,050,758 - 63,119,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0567,575,578 - 67,643,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0569,079,391 - 69,097,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,976,868 - 64,034,058 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1563,981,949 - 64,034,967 (+)NCBI
Celera565,882,184 - 65,907,477 (-)NCBICelera
Cytogenetic Map5q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541926,490,899 - 26,547,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,490,899 - 26,546,349 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1998,337,417 - 98,362,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl998,332,739 - 98,362,748 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0970,195,007 - 70,243,514 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11156,191,383 - 56,223,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,161,772 - 56,218,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1154,594,299 - 54,654,173 (+)NCBI
ROS_Cfam_1.01157,272,690 - 57,331,474 (+)NCBI
UMICH_Zoey_3.11155,775,923 - 55,835,949 (+)NCBI
UNSW_CanFamBas_1.01155,800,862 - 55,860,799 (+)NCBI
UU_Cfam_GSD_1.01156,499,979 - 56,559,879 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947171,109,141 - 171,133,324 (+)NCBI
SpeTri2.0NW_0049365247,656,523 - 7,680,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1240,859,270 - 240,918,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,842,735 - 240,918,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,090,577 - 269,149,183 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11240,272,507 - 40,321,740 (-)NCBI
ChlSab1.1 Ensembl1240,276,916 - 40,297,372 (-)Ensembl
Vero_WHO_p1.0NW_0236660352,236,283 - 2,258,310 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248251,773,158 - 1,899,120 (-)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,911,916 - 101,912,218UniSTSGRCh37
GRCh379101,911,607 - 101,911,935UniSTSGRCh37
Build 369100,951,737 - 100,952,039RGDNCBI36
Celera972,425,468 - 72,425,796UniSTS
Celera972,425,777 - 72,426,079RGD
Cytogenetic Map9q22UniSTS
HuRef971,510,265 - 71,510,593UniSTS
HuRef971,510,574 - 71,510,876UniSTS
Stanford-G3 RH Map93439.0UniSTS
GeneMap99-GB4 RH Map9323.03UniSTS
Whitehead-RH Map9364.0UniSTS
NCBI RH Map9838.6UniSTS
GeneMap99-G3 RH Map93337.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,911,902 - 101,912,034UniSTSGRCh37
Build 369100,951,723 - 100,951,855RGDNCBI36
Celera972,425,763 - 72,425,895RGD
Cytogenetic Map9q22UniSTS
HuRef971,510,560 - 71,510,692UniSTS
GeneMap99-GB4 RH Map9323.03UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,915,782 - 101,915,911UniSTSGRCh37
Build 369100,955,603 - 100,955,732RGDNCBI36
Celera972,429,643 - 72,429,772RGD
Cytogenetic Map9q22UniSTS
HuRef971,514,440 - 71,514,569UniSTS
TNG Radiation Hybrid Map938429.0UniSTS
Stanford-G3 RH Map93433.0UniSTS
GeneMap99-GB4 RH Map9322.43UniSTS
Whitehead-RH Map9367.5UniSTS
NCBI RH Map9837.7UniSTS
GeneMap99-G3 RH Map93331.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,906,763 - 101,907,041UniSTSGRCh37
Build 369100,946,584 - 100,946,862RGDNCBI36
Celera972,420,627 - 72,420,905RGD
Cytogenetic Map9q22UniSTS
HuRef971,505,424 - 71,505,702UniSTS
TNG Radiation Hybrid Map938433.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,915,889 - 101,916,074UniSTSGRCh37
Build 369100,955,710 - 100,955,895RGDNCBI36
Celera972,429,750 - 72,429,935RGD
Cytogenetic Map9q22UniSTS
HuRef971,514,547 - 71,514,732UniSTS
TNG Radiation Hybrid Map938425.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,908,256 - 101,908,565UniSTSGRCh37
Build 369100,948,077 - 100,948,386RGDNCBI36
Celera972,422,120 - 72,422,429RGD
Cytogenetic Map9q22UniSTS
HuRef971,506,917 - 71,507,226UniSTS
TNG Radiation Hybrid Map938433.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,911,573 - 101,912,467UniSTSGRCh37
Build 369100,951,394 - 100,952,288RGDNCBI36
Celera972,425,434 - 72,426,328RGD
HuRef971,510,231 - 71,511,125UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,915,769 - 101,915,940UniSTSGRCh37
Build 369100,955,590 - 100,955,761RGDNCBI36
Celera972,429,630 - 72,429,801RGD
Cytogenetic Map9q22UniSTS
HuRef971,514,427 - 71,514,598UniSTS
GeneMap99-GB4 RH Map9323.13UniSTS
NCBI RH Map9850.6UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,908,772 - 101,908,875UniSTSGRCh37
Build 369100,948,593 - 100,948,696RGDNCBI36
Celera972,422,636 - 72,422,739RGD
HuRef971,507,433 - 71,507,536UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,871,377 - 101,871,471UniSTSGRCh37
Build 369100,911,198 - 100,911,292RGDNCBI36
Celera972,385,245 - 72,385,339RGD
Cytogenetic Map9q22UniSTS
HuRef971,470,039 - 71,470,133UniSTS
TNG Radiation Hybrid Map938408.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,890,536 - 101,890,728UniSTSGRCh37
Build 369100,930,357 - 100,930,549RGDNCBI36
Celera972,404,400 - 72,404,592RGD
Cytogenetic Map9q22UniSTS
HuRef971,489,194 - 71,489,386UniSTS
GeneMap99-GB4 RH Map9323.13UniSTS
NCBI RH Map9850.6UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,893,631 - 101,893,761UniSTSGRCh37
Build 369100,933,452 - 100,933,582RGDNCBI36
Celera972,407,495 - 72,407,625RGD
Cytogenetic Map9q22UniSTS
HuRef971,492,285 - 71,492,415UniSTS
GeneMap99-GB4 RH Map9324.95UniSTS
NCBI RH Map9858.6UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,916,135 - 101,916,257UniSTSGRCh37
Build 369100,955,956 - 100,956,078RGDNCBI36
Celera972,429,996 - 72,430,118RGD
Cytogenetic Map9q22UniSTS
HuRef971,514,793 - 71,514,915UniSTS
GeneMap99-GB4 RH Map9323.13UniSTS
NCBI RH Map9850.6UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379101,878,289 - 101,878,433UniSTSGRCh37
Build 369100,918,110 - 100,918,254RGDNCBI36
Celera972,392,155 - 72,392,299RGD
Cytogenetic Map9q22UniSTS
HuRef971,476,949 - 71,477,093UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q22UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q22UniSTS
GeneMap99-GB4 RH Map9323.03UniSTS
Whitehead-RH Map9364.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR128-1hsa-miR-128-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20054641
MIR128-1hsa-miR-128-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIRLET7Chsa-let-7c-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19841744
MIR204hsa-miR-204-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20056717

Predicted Target Of
Summary Value
Count of predictions:5853
Count of miRNA genes:1055
Interacting mature miRNAs:1310
Transcripts:ENST00000374990, ENST00000374994, ENST00000546584, ENST00000547314, ENST00000548365, ENST00000549021, ENST00000549766, ENST00000550253, ENST00000552516, ENST00000552573
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
Medium 1994 1881 979 229 1477 119 2575 965 1595 317 1335 1473 126 1 1059 1530 5 1
Low 445 1110 747 395 474 346 1781 1232 2139 102 124 140 49 145 1258 1 1
Below cutoff 1


Nucleotide Sequences
RefSeq Transcripts NG_007461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001306210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH015633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ420419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ619019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ619020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY497473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF142853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF142854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU143401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB448229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000374990   ⟹   ENSP00000364129
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,105,111 - 99,153,649 (+)Ensembl
RefSeq Acc Id: ENST00000374994   ⟹   ENSP00000364133
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,105,113 - 99,154,192 (+)Ensembl
RefSeq Acc Id: ENST00000546584   ⟹   ENSP00000447707
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,127,934 - 99,132,739 (+)Ensembl
RefSeq Acc Id: ENST00000547314   ⟹   ENSP00000449934
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,104,038 - 99,132,726 (+)Ensembl
RefSeq Acc Id: ENST00000548365   ⟹   ENSP00000448518
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,127,874 - 99,132,703 (+)Ensembl
RefSeq Acc Id: ENST00000549021   ⟹   ENSP00000449028
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl999,127,775 - 99,138,064 (+)Ensembl
RefSeq Acc Id: ENST0000054976