RGD Reference Report - A transforming growth factor beta type I receptor that signals to activate gene expression. - Rat Genome Database

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A transforming growth factor beta type I receptor that signals to activate gene expression.

Authors: Bassing, CH  Yingling, JM  Howe, DJ  Wang, T  He, WW  Gustafson, ML  Shah, P  Donahoe, PK  Wang, XF 
Citation: Bassing CH, etal., Science 1994 Jan 7;263(5143):87-9.
RGD ID: 737663
Pubmed: (View Article at PubMed) PMID:8272871

Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Tgfbr1  (transforming growth factor, beta receptor 1)

Objects referenced in this article
0 TGFBR1 transforming growth factor beta receptor 1 All species
0 Tgfbr1 transforming growth factor, beta receptor I All species

Additional Information