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Gene: Pea15a (phosphoprotein enriched in astrocytes 15A) Mus musculus
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Symbol: Pea15a
Name: phosphoprotein enriched in astrocytes 15A
Description: This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 15 kDa phosphoprotein enriched in astrocytes; astrocytic phosphoprotein PEA-15; mammary transforming gene 1; Mat1; PEA-15; Pea15; phosphoprotein enriched in astrocytes 15; Pkcs15
Orthologs:
Related Pseudogenes: Gm19599   Pea15b  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381172,196,728 - 172,206,781 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371174,126,860 - 174,136,912 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,033,404 - 174,043,456 (-)NCBImm8
Celera1175,052,693 - 175,062,710 (-)NCBICelera
Cytogenetic Map1 H3NCBI
cM Map179.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pea15a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314453
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.