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Gene: Pla2g6 (phospholipase A2, group VI) Mus musculus
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Symbol: Pla2g6
Name: phospholipase A2, group VI
Description: Exhibits serine hydrolase activity. Predicted to be involved in several processes, including positive regulation of nitrogen compound metabolic process; positive regulation of secretion; and positive regulation of signal transduction. Predicted to localize to several cellular components, including the centriolar satellite; extracellular space; and mitochondrion. Used to study neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Orthologous to human PLA2G6 (phospholipase A2 group VI); PARTICIPATES IN arachidonic acid metabolic pathway; glutamate signaling pathway; glycerophospholipid metabolic pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; BB112799; caI-PLA2; group VI phospholipase A2; GVI PLA2; intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA(2)beta; iPLA2; iPLA2-beta; iPLA2beta; patatin-like phospholipase domain-containing protein 9; PNPLA9
Orthologs:
Homo sapiens (human) : PLA2G6 (phospholipase A2 group VI)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pla2g6 (phospholipase A2 group VI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pla2g6 (phospholipase A2 group VI)
Pan paniscus (bonobo/pygmy chimpanzee) : PLA2G6 (phospholipase A2 group VI)
Canis lupus familiaris (dog) : PLA2G6 (phospholipase A2 group VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pla2g6 (phospholipase A2 group VI)
Sus scrofa (pig) : PLA2G6 (phospholipase A2 group VI)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381579,286,228 - 79,328,385 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371579,116,658 - 79,158,598 (-)NCBIGRCm37mm9NCBIm37
MGSCv361579,113,483 - 79,155,423 (-)NCBImm8
Celera1581,406,243 - 81,448,094 (-)NCBICelera
Cytogenetic Map15 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pla2g6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732455
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.