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Gene: Slc12a2 (solute carrier family 12, member 2) Mus musculus
Symbol: Slc12a2
Name: solute carrier family 12, member 2
Description: Exhibits potassium ion transmembrane transporter activity. Involved in several processes, including cellular ion homeostasis; inorganic ion import across plasma membrane; and mammary gland duct morphogenesis. Localizes to several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in middle cerebral artery infarction. Orthologous to human SLC12A2 (solute carrier family 12 member 2); INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9330166H04Rik; basolateral Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; mBSC2; Nkcc1; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; solute carrier family 12 member 2; sy-ns
Homo sapiens (human) : SLC12A2 (solute carrier family 12 member 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Slc12a2 (solute carrier family 12 member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a2 (solute carrier family 12 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A2 (solute carrier family 12 member 2)
Canis lupus familiaris (dog) : SLC12A2 (solute carrier family 12 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a2 (solute carrier family 12 member 2)
Sus scrofa (pig) : SLC12A2 (solute carrier family 12 member 2)
Chlorocebus sabaeus (African green monkey) : SLC12A2 (solute carrier family 12 member 2)
Heterocephalus glaber (naked mole-rat) : Slc12a2 (solute carrier family 12 member 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1857,878,678 - 57,946,821 (+)EnsemblGRCm38mm10GRCm38
GRCm381857,878,512 - 57,946,821 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371858,038,332 - 58,106,475 (+)NCBIGRCm37mm9NCBIm37
MGSCv361858,004,047 - 58,072,174 (+)NCBImm8
Celera1859,157,060 - 59,258,313 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1832.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Slc12a2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732817
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.