Npy5r (neuropeptide Y receptor Y5) - Rat Genome Database
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Gene: Npy5r (neuropeptide Y receptor Y5) Mus musculus
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Symbol: Npy5r
Name: neuropeptide Y receptor Y5
RGD ID: 11017
MGI Page MGI
Description: Exhibits pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in chemical synaptic transmission. Localizes to membrane and neuron projection. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5); INTERACTS WITH clofibrate; dimethylarsinic acid; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC151353; MGC151355; neuropeptide Y receptor type 5; Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (Y5 receptor); NPY-Y5 receptor; NPY5-R; NPYY5-R; Y5; Y5 receptor; Y5R
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,132,617 - 67,140,746 (-)NCBIGRCm39mm39
GRCm38866,679,965 - 66,688,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,679,965 - 66,688,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv37869,203,864 - 69,211,993 (-)NCBIGRCm37mm9NCBIm37
MGSCv36869,608,956 - 69,617,083 (-)NCBImm8
Celera869,234,119 - 69,242,248 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map833.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8910290   PMID:9315606   PMID:9417917   PMID:9559948   PMID:9623983   PMID:9722158   PMID:9802393   PMID:10349636   PMID:10441733   PMID:10557353   PMID:10698177   PMID:10720571  
PMID:11042159   PMID:11076861   PMID:11166058   PMID:11217851   PMID:11287090   PMID:11579129   PMID:11784771   PMID:11978737   PMID:12439655   PMID:12477932   PMID:14525913   PMID:14755515  
PMID:15979311   PMID:16141072   PMID:16141073   PMID:16190896   PMID:16198492   PMID:16602821   PMID:16636293   PMID:17105869   PMID:17614946   PMID:18287559   PMID:18421274   PMID:19009645  
PMID:19482021   PMID:19877281   PMID:21267068   PMID:21873635   PMID:22342800   PMID:22367168   PMID:22768253   PMID:23218957   PMID:24316073   PMID:24548641   PMID:24952961   PMID:24985894  
PMID:26053317   PMID:27984021   PMID:28057538   PMID:28485050  


Genomics

Comparative Map Data
Npy5r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,132,617 - 67,140,746 (-)NCBIGRCm39mm39
GRCm38866,679,965 - 66,688,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,679,965 - 66,688,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv37869,203,864 - 69,211,993 (-)NCBIGRCm37mm9NCBIm37
MGSCv36869,608,956 - 69,617,083 (-)NCBImm8
Celera869,234,119 - 69,242,248 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map833.15NCBI
NPY5R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4163,343,892 - 163,351,934 (+)EnsemblGRCh38hg38GRCh38
GRCh384163,336,968 - 163,352,277 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374164,265,062 - 164,273,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364164,484,541 - 164,492,536 (+)NCBINCBI36hg18NCBI36
Build 344164,622,695 - 164,630,689NCBI
Celera4161,597,299 - 161,605,294 (+)NCBI
Cytogenetic Map4q32.2NCBI
HuRef4160,019,138 - 160,027,132 (+)NCBIHuRef
CHM1_14164,241,432 - 164,249,529 (+)NCBICHM1_1
Npy5r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01624,796,685 - 24,805,730 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,797,124 - 24,805,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01624,680,437 - 24,688,657 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41624,765,175 - 24,773,132 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11624,765,172 - 24,773,128 (+)NCBI
Celera1623,179,732 - 23,187,687 (+)NCBICelera
Cytogenetic Map16p14NCBI
RH 3.4 Map16280.0RGD
Npy5r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540341,667,632 - 41,675,619 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540341,667,632 - 41,675,619 (-)NCBIChiLan1.0ChiLan1.0
NPY5R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14167,392,174 - 167,400,258 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v04155,603,739 - 155,612,302 (+)NCBIMhudiblu_PPA_v0panPan3
NPY5R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1559,606,902 - 59,608,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11559,600,212 - 59,608,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Npy5r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365552,248,699 - 2,252,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPY5R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl852,174,299 - 52,183,334 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1852,173,906 - 52,183,336 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2855,301,393 - 55,310,791 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPY5R
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17109,790,907 - 109,801,929 (+)NCBI
Npy5r
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475813,518,722 - 13,521,292 (-)NCBI

Position Markers
PMC123072P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38866,680,864 - 66,681,114UniSTSGRCm38
MGSCv37869,204,763 - 69,205,013UniSTSGRCm37
Celera869,235,018 - 69,235,268UniSTS
Cytogenetic Map8B3-C2UniSTS
Npy5r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38866,681,866 - 66,682,103UniSTSGRCm38
Celera869,236,020 - 69,236,257UniSTS
Cytogenetic Map8B3-C2UniSTS
cM Map833.15UniSTS
PMC28100P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38866,681,036 - 66,681,948UniSTSGRCm38
MGSCv37869,204,935 - 69,205,847UniSTSGRCm37
Celera869,235,190 - 69,236,102UniSTS
Cytogenetic Map8B3-C2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:132
Interacting mature miRNAs:133
Transcripts:ENSMUST00000070810
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070810   ⟹   ENSMUSP00000065157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl866,679,965 - 66,688,094 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211920   ⟹   ENSMUSP00000148410
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl866,680,721 - 66,688,128 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212563   ⟹   ENSMUSP00000148589
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl866,680,569 - 66,688,047 (-)Ensembl
RefSeq Acc Id: NM_001358957   ⟹   NP_001345886
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,132,617 - 67,140,746 (-)NCBI
GRCm38866,679,965 - 66,688,094 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001358958   ⟹   NP_001345887
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,132,617 - 67,140,746 (-)NCBI
GRCm38866,679,965 - 66,688,094 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016708   ⟹   NP_057917
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,132,617 - 67,140,746 (-)NCBI
GRCm38866,679,965 - 66,688,094 (-)NCBI
MGSCv37869,203,864 - 69,211,993 (-)RGD
Celera869,234,119 - 69,242,248 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153813   ⟹   XP_036009706
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,132,622 - 67,135,711 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_057917   ⟸   NM_016708
- UniProtKB: O70342 (UniProtKB/Swiss-Prot),   Q543U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001345886   ⟸   NM_001358957
RefSeq Acc Id: NP_001345887   ⟸   NM_001358958
RefSeq Acc Id: ENSMUSP00000065157   ⟸   ENSMUST00000070810
RefSeq Acc Id: ENSMUSP00000148410   ⟸   ENSMUST00000211920
RefSeq Acc Id: ENSMUSP00000148589   ⟸   ENSMUST00000212563
RefSeq Acc Id: XP_036009706   ⟸   XM_036153813
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:8667189
Promoter ID:EPDNEW_M11626
Type:multiple initiation site
Name:Npy5r_1
Description:Mus musculus neuropeptide Y receptor Y5 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38866,688,017 - 66,688,077EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108082 AgrOrtholog
Ensembl Genes ENSMUSG00000044014 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000065157 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148410 UniProtKB/Swiss-Prot
  ENSMUSP00000148589 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070810 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211920 UniProtKB/Swiss-Prot
  ENSMUST00000212563 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY5_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108082 ENTREZGENE
NCBI Gene 18168 ENTREZGENE
PANTHER PTHR24241:SF139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npy5r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEY5R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.10685 ENTREZGENE
UniProt NPY5R_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q543U8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35380 UniProtKB/Swiss-Prot
  Q9JMK1 UniProtKB/Swiss-Prot