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Gene: Ikbkb (inhibitor of kappaB kinase beta) Mus musculus
Symbol: Ikbkb
Name: inhibitor of kappaB kinase beta
Description: Exhibits IkappaB kinase activity and protein phosphatase binding activity. Involved in several processes, including B cell homeostasis; positive regulation of ion transport; and tumor necrosis factor-mediated signaling pathway. Localizes to CD40 receptor complex and cytoplasmic side of plasma membrane. Is expressed in several structures, including genitourinary system and musculature. Human ortholog(s) of this gene implicated in breast cancer; dermatitis; primary immunodeficiency disease; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (S)-colchicine; 1,2-Naphthoquinone; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI132552; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; IKK-B; IKK-beta; IKK2; IKK2/beta; IKK[b]; IKKbeta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl822,659,212 - 22,706,589 (-)EnsemblGRCm38mm10GRCm38
GRCm38822,659,205 - 22,706,589 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37823,769,677 - 23,817,055 (-)NCBIGRCm37mm9NCBIm37
MGSCv36824,125,308 - 24,172,108 (-)NCBImm8
Celera824,149,472 - 24,196,863 (-)NCBICelera
Cytogenetic Map8A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ikbkb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733969
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.