Chchd6 (coiled-coil-helix-coiled-coil-helix domain containing 6) - Rat Genome Database
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Gene: Chchd6 (coiled-coil-helix-coiled-coil-helix domain containing 6) Mus musculus
Analyze
Symbol: Chchd6
Name: coiled-coil-helix-coiled-coil-helix domain containing 6
RGD ID: 1549972
MGI Page MGI
Description: Orthologous to human CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6); PARTICIPATES IN mitochondrial protein import pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0710001P09Rik; 1700021B03Rik; coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; Mico; MICOS complex subunit Mic25; Micos25
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39689,360,128 - 89,572,634 (-)NCBIGRCm39mm39
GRCm39 Ensembl689,360,128 - 89,572,634 (-)Ensembl
GRCm38689,383,146 - 89,595,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl689,383,146 - 89,595,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv37689,333,140 - 89,545,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv36689,348,800 - 89,561,256 (-)NCBImm8
Celera691,307,487 - 91,519,050 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635  
PMID:28190767   PMID:28378742   PMID:28706196   PMID:30068389   PMID:31040226   PMID:32325033  


Genomics

Comparative Map Data
Chchd6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39689,360,128 - 89,572,634 (-)NCBIGRCm39mm39
GRCm39 Ensembl689,360,128 - 89,572,634 (-)Ensembl
GRCm38689,383,146 - 89,595,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl689,383,146 - 89,595,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv37689,333,140 - 89,545,646 (-)NCBIGRCm37mm9NCBIm37
MGSCv36689,348,800 - 89,561,256 (-)NCBImm8
Celera691,307,487 - 91,519,050 (-)NCBICelera
Cytogenetic Map6D1NCBI
CHCHD6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3126,704,240 - 126,960,420 (+)EnsemblGRCh38hg38GRCh38
GRCh383126,704,240 - 126,960,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373126,423,083 - 126,679,263 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,905,808 - 128,161,934 (+)NCBINCBI36hg18NCBI36
Build 343127,905,815 - 128,161,942NCBI
Celera3124,847,408 - 125,103,434 (+)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3123,803,031 - 124,058,229 (+)NCBIHuRef
CHM1_13126,386,071 - 126,641,958 (+)NCBICHM1_1
Chchd6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24121,803,501 - 122,024,209 (-)NCBI
Rnor_6.0 Ensembl4121,340,952 - 121,565,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04121,340,952 - 121,565,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04183,964,605 - 184,187,039 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44123,458,141 - 123,681,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14123,702,632 - 123,926,088 (-)NCBI
Celera4110,754,437 - 110,975,179 (-)NCBICelera
Cytogenetic Map4q34NCBI
Chchd6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542916,546,352 - 16,786,632 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542916,546,397 - 16,786,139 (-)NCBIChiLan1.0ChiLan1.0
CHCHD6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13131,062,167 - 131,316,916 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v03123,747,049 - 124,003,254 (+)NCBIMhudiblu_PPA_v0panPan3
CHCHD6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.120871,137 - 1,120,433 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CHCHD6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1373,107,228 - 73,254,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11373,102,168 - 73,262,956 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21380,739,004 - 80,827,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHCHD6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12254,019,128 - 54,276,242 (-)NCBI
ChlSab1.1 Ensembl2254,025,361 - 54,276,197 (-)Ensembl
Chchd6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249002,500,357 - 2,752,134 (+)NCBI

Position Markers
AU014819  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38689,547,679 - 89,547,818UniSTSGRCm38
MGSCv37689,497,673 - 89,497,812UniSTSGRCm37
Celera691,471,036 - 91,471,175UniSTS
Cytogenetic Map6D2UniSTS
Whitehead/MRC_RH6914.92UniSTS
PMC313053P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38689,555,529 - 89,555,722UniSTSGRCm38
MGSCv37689,505,523 - 89,505,716UniSTSGRCm37
Celera691,478,886 - 91,479,079UniSTS
Cytogenetic Map6D2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:147
Interacting mature miRNAs:153
Transcripts:ENSMUST00000032172, ENSMUST00000113550
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001167736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_025351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ177996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY278681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF410100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032172   ⟹   ENSMUSP00000032172
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl689,383,151 - 89,595,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113550   ⟹   ENSMUSP00000109179
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl689,383,146 - 89,595,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204654   ⟹   ENSMUSP00000145207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl689,569,341 - 89,595,611 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204970
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl689,418,347 - 89,595,604 (-)Ensembl
RefSeq Acc Id: NM_001167736   ⟹   NP_001161208
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39689,360,128 - 89,572,634 (-)NCBI
GRCm38689,383,146 - 89,595,652 (-)NCBI
MGSCv37689,333,140 - 89,545,646 (-)RGD
Celera691,307,487 - 91,519,050 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_025351   ⟹   NP_079627
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39689,360,128 - 89,572,634 (-)NCBI
GRCm38689,383,146 - 89,595,652 (-)NCBI
MGSCv37689,333,140 - 89,545,646 (-)RGD
Celera691,307,487 - 91,519,050 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_079627   ⟸   NM_025351
- Peptide Label: isoform 1
- UniProtKB: Q91VN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001161208   ⟸   NM_001167736
- Peptide Label: isoform 2
- UniProtKB: Q91VN4 (UniProtKB/Swiss-Prot),   E9Q4M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032172   ⟸   ENSMUST00000032172
RefSeq Acc Id: ENSMUSP00000109179   ⟸   ENSMUST00000113550
RefSeq Acc Id: ENSMUSP00000145207   ⟸   ENSMUST00000204654
Protein Domains
CHCH

Promoters
RGD ID:6839071
Promoter ID:MM_KWN:46851
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:NM_001167736,   NM_025351,   UC009CWI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36689,545,284 - 89,545,784 (-)MPROMDB
RGD ID:6890398
Promoter ID:EPDNEW_M8650
Type:initiation region
Name:Chchd6_1
Description:Mus musculus coiled-coil-helix-coiled-coil-helix domain containing6 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38689,595,637 - 89,595,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913348 AgrOrtholog
Ensembl Genes ENSMUSG00000030086 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032172 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109179 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000145207 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032172 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113550 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000204654 UniProtKB/TrEMBL
InterPro MIC25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66098 UniProtKB/Swiss-Prot
MGD MGI:1913348 ENTREZGENE
NCBI Gene 66098 ENTREZGENE
PANTHER PTHR47609 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Chchd6 PhenoGen
PROSITE CHCH UniProtKB/Swiss-Prot
UniProt A0A0N4SVQ9_MOUSE UniProtKB/TrEMBL
  E9Q4M4 ENTREZGENE, UniProtKB/TrEMBL
  MIC25_MOUSE UniProtKB/Swiss-Prot
  Q3TJS8_MOUSE UniProtKB/TrEMBL
  Q8C2Z6_MOUSE UniProtKB/TrEMBL
  Q91VN4 ENTREZGENE
  Q9DA45_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UNQ1 UniProtKB/Swiss-Prot
  Q9D5I5 UniProtKB/Swiss-Prot
  Q9DAM8 UniProtKB/Swiss-Prot