Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase) Mus musculus
Analyze
Symbol: Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Description: Exhibits several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Localizes to several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute myeloid leukemia; and chronic myeloid leukemia. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase); PARTICIPATES IN p53 signaling pathway; platelet-derived growth factor signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroperoxycyclophosphamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Abelson murine leukemia oncogene; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl; AI325092; c-Abl; c-abl oncogene 1, receptor tyrosine kinase; c-abl protein, type I; c-abl protein, type II; c-abl protein, type III; E430008G22Rik; MGC117749; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl231,688,376 - 31,804,227 (+)EnsemblGRCm38mm10GRCm38
GRCm38231,688,244 - 31,807,093 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37231,544,076 - 31,659,747 (+)NCBIGRCm37mm9NCBIm37
MGSCv36231,581,991 - 31,626,236 (+)NCBImm8
Celera231,389,208 - 31,506,940 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Abl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332211
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-05-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.