Clu (clusterin) - Rat Genome Database

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Gene: Clu (clusterin) Mus musculus
Symbol: Clu
Name: clusterin
RGD ID: 68979
Description: Predicted to enable several functions, including amyloid-beta binding activity; low-density lipoprotein particle receptor binding activity; and misfolded protein binding activity. Involved in immune complex clearance; positive regulation of apoptotic process; and regulation of protein metabolic process. Located in cytosol; mitochondrion; and nucleus. Is active in synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; diabetic retinopathy; exfoliation syndrome; and muscular disease (multiple). Orthologous to human CLU (clusterin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A; AI893575; apo-J; ApoJ; Apolipoprotein J; C; Cli; clustrin; complement lysis inhibitor; D14Ucl; D14Ucla3; Sg; Sgp; Sgp-2; Sgp2; SP-; SP-40; Sugp; Sugp-2; sulfated glycoprotein 2; testosterone repressed prostate message; testosterone repressed prostate message-2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391466,205,932 - 66,218,997 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)EnsemblGRCm39 Ensembl
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBIMGSCv36mm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atherosclerosis  (ISO)
Atrophy  (ISO)
autosomal dominant nocturnal frontal lobe epilepsy  (ISO)
benign familial infantile seizures 6  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Allograft Nephropathy  (ISO)
chronic kidney disease  (ISO)
cicatricial pemphigoid  (ISO)
Cognitive Dysfunction  (ISO)
conjunctival disease  (ISO)
coronary artery disease  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
exfoliation syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fuchs' endothelial dystrophy  (IEP,ISO)
gelatinous drop-like corneal dystrophy  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
inclusion body myositis  (ISO)
invasive ductal carcinoma  (ISO)
iron metabolism disease  (IEP)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
lupus nephritis  (IEP)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
muscular disease  (ISO)
mycosis fungoides  (ISO)
myocardial infarction  (ISO)
nasal cavity adenocarcinoma  (ISO)
Neointima  (IMP)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
Pituitary Neoplasms  (IMP)
pre-eclampsia  (ISO)
prostate adenocarcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (IMP)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
skin papilloma  (IEP)
squamous cell carcinoma  (IMP)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
vitiligo  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-Dichlorobenzophenone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
aluminium oxide  (EXP)
ammonia  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
bacitracin  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
carnosic acid  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chloroform  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
cumene  (EXP)
Cuprizon  (ISO)
cyanuric acid  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-penicillamine  (ISO)
dacarbazine  (ISO)
daidzein  (ISO)
deferasirox  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (EXP,ISO)
graphite  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
isocyanuric acid  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
levamisole  (ISO)
Licochalcone B  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP)
m-xylene  (ISO)
maneb  (EXP)
Meclizine  (ISO)
megestrol  (ISO)
melamine  (ISO)
mercury dichloride  (ISO)
metaproterenol  (EXP)
Methazolamide  (ISO)
methimazole  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
mitoxantrone  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
natamycin  (EXP)
nickel atom  (EXP,ISO)
nifedipine  (ISO)
nimodipine  (EXP)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
nystatin  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
omega-conotoxin GVIA  (ISO)
orciprenaline  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
razoxane  (EXP)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
styrene  (ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
theophylline  (ISO)
thiabendazole  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
triazines  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell morphogenesis  (ISO)
cellular response to growth factor stimulus  (ISO)
central nervous system myelin maintenance  (ISO)
chaperone-mediated protein complex assembly  (ISO)
chaperone-mediated protein folding  (ISO)
endocrine pancreas development  (ISO)
estrous cycle  (ISO)
immune complex clearance  (IMP)
intrinsic apoptotic signaling pathway  (ISO)
microglial cell activation  (ISO)
microglial cell proliferation  (ISO)
negative regulation of amyloid fibril formation  (IMP,ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of response to endoplasmic reticulum stress  (ISO)
neuron projection morphogenesis  (ISO)
positive regulation of amyloid-beta formation  (IMP)
positive regulation of apoptotic process  (IDA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
protein import  (ISO)
protein stabilization  (ISO)
protein targeting to lysosome involved in chaperone-mediated autophagy  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of apoptotic process  (IBA)
regulation of cell population proliferation  (ISO)
regulation of neuronal signal transduction  (ISO)
response to light stimulus  (ISO)
response to misfolded protein  (ISO)
response to potassium ion  (ISO)
response to virus  (ISO)


References - curated
# Reference Title Reference Citation
1. Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. Burdon KP, etal., Mol Vis. 2008 Sep 22;14:1727-36.
2. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
3. Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. Chen M, etal., Gynecol Obstet Invest. 2005;60(3):133-8. Epub 2005 May 27.
4. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Chesnokova V, etal., Mol Endocrinol. 2012 Dec;26(12):2092-103. doi: 10.1210/me.2012-1158. Epub 2012 Oct 9.
5. Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis. Ferrer I, etal., Brain Pathol. 2005 Apr;15(2):101-8.
6. Effects of clusterin over-expression on metastatic progression and therapy in breast cancer. Flanagan L, etal., BMC Cancer. 2010 Mar 22;10:107. doi: 10.1186/1471-2407-10-107.
7. Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model. Franquesa M, etal., Stem Cells Dev. 2012 Nov 20;21(17):3125-35. doi: 10.1089/scd.2012.0096. Epub 2012 May 18.
8. Decreased plasma levels of clusterin in patients with psoriasis. Garcia-Rodriguez S, etal., Actas Dermosifiliogr. 2013 Jul-Aug;104(6):497-503. doi: 10.1016/ Epub 2013 Mar 21.
9. Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Giannakopoulos P, etal., Acta Neuropathol. 1998 Apr;95(4):387-94.
10. Expression of clusterin in Muller cells of the rat retina after pressure-induced ischemia. Gwon JS, etal., Glia. 2004 Jul;47(1):35-45.
11. Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis. Hernandez C, etal., Diabetes Metab Res Rev. 2013 Sep;29(6):499-506. doi: 10.1002/dmrr.2419.
12. Clusterin attenuates the development of renal fibrosis. Jung GS, etal., J Am Soc Nephrol. 2012 Jan;23(1):73-85. doi: 10.1681/ASN.2011010048. Epub 2011 Nov 3.
13. Increased clusterin expression in Fuchs' endothelial dystrophy. Jurkunas UV, etal., Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2946-55. doi: 10.1167/iovs.07-1405. Epub 2008 Mar 31.
14. Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors. Kalka K, etal., Cancer Res. 2000 Nov 1;60(21):5984-7.
15. The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats. Kaya-Dagistanli F and Ozturk M, Acta Histochem. 2013 Jul;115(6):577-86. doi: 10.1016/j.acthis.2012.12.007. Epub 2013 Jan 23.
16. Protective role of clusterin/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells. Kim HJ, etal., Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1558-64. doi: 10.1161/ATVBAHA.109.190058. Epub 2009 Aug 20.
17. A signaling network in phenylephrine-induced benign prostatic hyperplasia. Kim J, etal., Endocrinology. 2009 Aug;150(8):3576-83. doi: 10.1210/en.2008-1782. Epub 2009 May 14.
18. Protective effect of clusterin on blood-retinal barrier breakdown in diabetic retinopathy. Kim JH, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1659-65. doi: 10.1167/iovs.09-3615. Epub 2009 Oct 29.
19. Retinal expression of clusterin in the streptozotocin-induced diabetic rat. Kim YS, etal., Brain Res. 2003 Jun 20;976(1):53-9.
20. Prognostic significance of clusterin immunoreactivity in breast cancer. Kruger S, etal., Neoplasma. 2007;54(1):46-50.
21. Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Krumbiegel M, etal., Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801. doi: 10.1167/iovs.08-2339. Epub 2009 Jan 31.
22. Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis. Li J, etal., J Int Med Res. 2012;40(2):545-55.
23. Secretory clusterin is upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells. Liu X, etal., Acta Physiol (Oxf). 2014 Jul 29. doi: 10.1111/apha.12352.
24. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
25. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
26. MGDs mouse GO annotations MGD data from the GO Consortium
28. Tubular up-regulation of clusterin mRNA in murine lupus-like nephritis. Moll S, etal., Am J Pathol. 1998 Apr;152(4):953-62.
29. Changes in conjunctival clusterin expression in severe ocular surface disease. Nakamura T, etal., Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1702-7.
30. [Molecular mechanism of pathological keratinization in severe ocular surface diseases]. Nakamura T, Nippon Ganka Gakkai Zasshi. 2004 Nov;108(11):654-64.
31. An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice. Navab M, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1932-7. Epub 2005 Jun 16.
32. Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein. Newkirk MM, etal., J Rheumatol. 1999 Mar;26(3):597-603.
33. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies. Nishida K, etal., Br J Ophthalmol. 1999 Oct;83(10):1178-82.
34. Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer. Niu Z, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Dec;44(12):991-8. doi: 10.1093/abbs/gms091. Epub 2012 Oct 25.
35. Complement activation following optic nerve crush in the adult rat. Ohlsson M, etal., J Neurotrauma. 2003 Sep;20(9):895-904.
36. Plasma clusterin concentrations may predict resistance to intravenous immunoglobulin in patients with Kawasaki disease. Ou-Yang MC, etal., ScientificWorldJournal. 2013 Jul 15;2013:382523. doi: 10.1155/2013/382523. eCollection 2013.
37. Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Padhy B, etal., Exp Eye Res. 2014 Jul 21;127C:69-76. doi: 10.1016/j.exer.2014.07.005.
38. Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina. Park CH, etal., Curr Eye Res. 2007 Dec;32(12):1055-63.
39. Overexpression of clusterin in human breast carcinoma. Redondo M, etal., Am J Pathol. 2000 Aug;157(2):393-9.
40. Mouse MP Annotation Import Pipeline RGD automated import pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Prognostic impact of polymorphisms in the MYBL2 interacting genes in breast cancer. Shi H, etal., Breast Cancer Res Treat. 2012 Feb;131(3):1039-47. doi: 10.1007/s10549-011-1826-2. Epub 2011 Oct 26.
44. Deficiency of clusterin inhibits neointimal hyperplasia after vascular injury. Shirasawa T, etal., J Atheroscler Thromb. 2009;16(6):772-81. Epub 2009 Dec 22.
45. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Smith SB, etal., Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2193-201.
46. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Suzuki S, etal., Cancer Sci. 2013 Dec;104(12):1711-7. doi: 10.1111/cas.12292. Epub 2013 Oct 28.
47. NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays. Takase O, etal., Clin Exp Nephrol. 2008 Jun;12(3):181-8. doi: 10.1007/s10157-008-0038-5. Epub 2008 Feb 15.
48. Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. Thomas-Tikhonenko A, etal., Cancer Res. 2004 May 1;64(9):3126-36.
49. Prognostic factors in 105 Japanese cases of mycosis fungoides and Sezary syndrome: clusterin expression as a novel prognostic factor. Tobisawa S, etal., J Dermatol Sci. 2013 Sep;71(3):160-6. doi: 10.1016/j.jdermsci.2013.04.020. Epub 2013 May 2.
50. Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats. Togashi Y, etal., Exp Toxicol Pathol. 2013 Nov;65(7-8):1137-43. doi: 10.1016/j.etp.2013.05.005. Epub 2013 Jun 21.
51. Gene expression profiling in sinonasal adenocarcinoma. Tripodi D, etal., BMC Med Genomics. 2009 Nov 10;2:65. doi: 10.1186/1755-8794-2-65.
52. The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. Tuncdemir M and Ozturk M, J Mol Histol. 2008 Dec;39(6):605-16. doi: 10.1007/s10735-008-9201-2. Epub 2008 Oct 24.
53. Intravenous clusterin administration reduces myocardial infarct size in rats. Van Dijk A, etal., Eur J Clin Invest. 2010 Oct;40(10):893-902. doi: 10.1111/j.1365-2362.2010.02345.x.
54. Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats. Vinken P, etal., Toxicol Pathol. 2012 Oct;40(7):1049-62. Epub 2012 May 11.
55. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
56. Delayed, but prolonged increases in astrocytic clusterin (ApoJ) mRNA expression following acute cortical spreading depression in the rat: evidence for a role of clusterin in ischemic tolerance. Wiggins AK, etal., Brain Res Mol Brain Res 2003 May 26;114(1):20-30.
57. A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis. Yanaba K, etal., Arch Dermatol Res. 2012 Aug;304(6):459-63. doi: 10.1007/s00403-012-1219-3. Epub 2012 Feb 17.
58. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Yu HR, etal., Pediatr Cardiol. 2010 Nov;31(8):1151-6. doi: 10.1007/s00246-010-9769-7. Epub 2010 Aug 15.
59. Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2006 May;47(5):1982-90.
60. Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. Zhang Q, etal., Biomark Med. 2014 Jan;8(1):85-94. doi: 10.2217/bmm.13.106.
Additional References at PubMed
PMID:1436033   PMID:1864465   PMID:2045098   PMID:2780565   PMID:7499242   PMID:7605616   PMID:7607697   PMID:7665171   PMID:7743930   PMID:7780178   PMID:7881131   PMID:7894166  
PMID:7949730   PMID:8026071   PMID:8075499   PMID:8169523   PMID:8352774   PMID:8354695   PMID:8431639   PMID:8565829   PMID:8769098   PMID:8786143   PMID:8827514   PMID:8828830  
PMID:8833241   PMID:8879484   PMID:8889548   PMID:8939902   PMID:8957692   PMID:9010342   PMID:9056387   PMID:9203053   PMID:9247197   PMID:9359832   PMID:9367891   PMID:9697832  
PMID:9895271   PMID:10066740   PMID:10349636   PMID:10514484   PMID:10694874   PMID:10922068   PMID:11042159   PMID:11067863   PMID:11076861   PMID:11123208   PMID:11123922   PMID:11217851  
PMID:11231633   PMID:11533682   PMID:11830565   PMID:11865066   PMID:11906924   PMID:11973313   PMID:12145324   PMID:12163409   PMID:12466851   PMID:12477932   PMID:12551933   PMID:12622243  
PMID:12824284   PMID:12882985   PMID:14610273   PMID:14681479   PMID:14741101   PMID:15031101   PMID:15126113   PMID:15146195   PMID:15226823   PMID:15257138   PMID:15358631   PMID:15489334  
PMID:15747579   PMID:15869496   PMID:16141072   PMID:16141073   PMID:16452087   PMID:16452096   PMID:16473512   PMID:16602821   PMID:16865725   PMID:16944957   PMID:17168649   PMID:17274979  
PMID:17330941   PMID:17359935   PMID:17374359   PMID:17451556   PMID:17597618   PMID:17989432   PMID:18075502   PMID:18186922   PMID:18287559   PMID:18554318   PMID:18554319   PMID:18554416  
PMID:18620027   PMID:19288494   PMID:19320717   PMID:19357365   PMID:19401549   PMID:19449303   PMID:19784068   PMID:19878774   PMID:20007348   PMID:20017954   PMID:20376577   PMID:20487000  
PMID:20692254   PMID:21083616   PMID:21099169   PMID:21151910   PMID:21242307   PMID:21267068   PMID:21282577   PMID:21290478   PMID:21385577   PMID:21464964   PMID:21505792   PMID:21549685  
PMID:21873635   PMID:21953454   PMID:22008794   PMID:22130675   PMID:22197644   PMID:22275070   PMID:22440257   PMID:22575505   PMID:22866057   PMID:22967998   PMID:23055941   PMID:23300469  
PMID:23454691   PMID:23457489   PMID:23515283   PMID:23595219   PMID:23673647   PMID:23805218   PMID:23831077   PMID:23863479   PMID:24006456   PMID:24058167   PMID:24154525   PMID:24366862  
PMID:24381170   PMID:24477687   PMID:24478351   PMID:24569077   PMID:24684302   PMID:24825475   PMID:24865838   PMID:24866235   PMID:24952961   PMID:25148511   PMID:25313862   PMID:25503391  
PMID:25775596   PMID:26076167   PMID:26150485   PMID:26282207   PMID:26561650   PMID:26826245   PMID:27148688   PMID:27221710   PMID:27378688   PMID:27507650   PMID:27626380   PMID:27649757  
PMID:27939882   PMID:27965092   PMID:28378742   PMID:28489004   PMID:28558636   PMID:28671696   PMID:28687930   PMID:28701379   PMID:28974563   PMID:29133960   PMID:29180573   PMID:29229391  
PMID:29476977   PMID:29563234   PMID:29768404   PMID:30208054   PMID:30295351   PMID:30585162   PMID:30704515   PMID:30940800   PMID:31019301   PMID:31073041   PMID:31323030   PMID:31739636  
PMID:32325033   PMID:32332780   PMID:32913205   PMID:32942336   PMID:33060605   PMID:33078455   PMID:33250918   PMID:33261653   PMID:33567267   PMID:33707780   PMID:33921872   PMID:34292881  
PMID:34616039   PMID:34705356   PMID:34815802   PMID:35218723   PMID:35253855   PMID:35364055   PMID:35917813   PMID:36417873   PMID:36653890   PMID:36870313   PMID:37143090  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391466,205,932 - 66,218,997 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)EnsemblGRCm39 Ensembl
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBIMGSCv36mm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21540,161,068 - 40,200,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,174,617 - 40,200,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,026,339 - 42,065,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,176,537 - 43,215,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,621,373 - 41,660,612 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Celera1539,832,711 - 39,871,901 (+)NCBICelera
Cytogenetic Map15p12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540350,160,598 - 50,175,876 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,160,598 - 50,175,876 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1821,842,687 - 21,859,551 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,867,973 - 26,884,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,070,053 - 24,086,934 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,070,053 - 24,083,523 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12529,982,811 - 29,999,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,982,811 - 29,999,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,569,577 - 30,586,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,173,217 - 30,190,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,173,100 - 30,195,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,103,442 - 30,120,185 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,984,486 - 30,001,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,150,889 - 30,167,668 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1411,336,595 - 11,349,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,336,585 - 11,352,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,516,644 - 12,527,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1825,704,441 - 25,721,789 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,703,257 - 25,721,789 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,420,009 - 16,437,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Clu
425 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1418
Count of miRNA genes:555
Interacting mature miRNAs:643
Transcripts:ENSMUST00000022616, ENSMUST00000127387, ENSMUST00000128539, ENSMUST00000138191, ENSMUST00000138665, ENSMUST00000144619, ENSMUST00000146990, ENSMUST00000152903, ENSMUST00000153460
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
10043888Cia51_mcollagen induced arthritis QTL 51 (mouse)Not determined146610389368785736Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,981,383 - 65,981,483UniSTSGRCm38
MGSCv371466,600,220 - 66,600,320UniSTSGRCm37
Celera1451,264,605 - 51,264,705UniSTS
Cytogenetic Map14D1UniSTS
cM Map1428.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1451,264,560 - 51,264,733UniSTS
Cytogenetic Map14D1UniSTS
cM Map1428.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371466,598,664 - 66,599,755UniSTSGRCm37
Celera1451,270,456 - 51,271,087UniSTS
Cytogenetic Map14D1UniSTS
cM Map1428.0UniSTS
cM Map1428.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,970,704 - 65,970,858UniSTSGRCm38
MGSCv371466,589,541 - 66,589,695UniSTSGRCm37
Celera1463,723,513 - 63,723,659UniSTS
Cytogenetic Map14D1UniSTS
cM Map1428.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D1UniSTS
cM Map1428.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,979,827 - 65,980,918UniSTSGRCm38
MGSCv371466,598,664 - 66,599,755UniSTSGRCm37
Celera1451,265,170 - 51,266,261UniSTS
Cytogenetic Map14D1UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001422221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF182509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF248057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF248058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP769702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY248781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK623407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L05670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S70244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000022616   ⟹   ENSMUSP00000022616
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)Ensembl
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127387   ⟹   ENSMUSP00000114720
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,208,069 - 66,213,314 (+)Ensembl
GRCm38.p6 Ensembl1465,970,620 - 65,975,865 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128539   ⟹   ENSMUSP00000121485
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,208,507 - 66,213,226 (+)Ensembl
GRCm38.p6 Ensembl1465,971,058 - 65,975,777 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138191   ⟹   ENSMUSP00000117555
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,208,253 - 66,213,291 (+)Ensembl
GRCm38.p6 Ensembl1465,970,804 - 65,975,842 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138665   ⟹   ENSMUSP00000121056
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,206,091 - 66,213,095 (+)Ensembl
GRCm38.p6 Ensembl1465,968,642 - 65,975,646 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144619   ⟹   ENSMUSP00000117953
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,208,752 - 66,212,411 (+)Ensembl
GRCm38.p6 Ensembl1465,971,303 - 65,974,962 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146990
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,206,103 - 66,209,986 (+)Ensembl
GRCm38.p6 Ensembl1465,968,654 - 65,972,537 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152903
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,212,118 - 66,213,423 (+)Ensembl
GRCm38.p6 Ensembl1465,974,669 - 65,975,974 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153460   ⟹   ENSMUSP00000121633
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,207,167 - 66,213,410 (+)Ensembl
GRCm38.p6 Ensembl1465,969,718 - 65,975,961 (+)Ensembl
RefSeq Acc Id: NM_013492   ⟹   NP_038520
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm391466,205,932 - 66,218,997 (+)NCBI
GRCm381465,968,483 - 65,981,548 (+)NCBI
MGSCv371466,587,320 - 66,600,382 (+)RGD
Celera1451,264,543 - 51,272,775 (-)RGD
RefSeq Acc Id: XM_006518503   ⟹   XP_006518566
Mouse AssemblyChrPosition (strand)Source
GRCm391466,208,454 - 66,218,997 (+)NCBI
GRCm381465,971,012 - 65,981,548 (+)NCBI
RefSeq Acc Id: XM_006518504   ⟹   XP_006518567
Mouse AssemblyChrPosition (strand)Source
GRCm391466,207,085 - 66,218,997 (+)NCBI
GRCm381465,969,711 - 65,981,548 (+)NCBI
RefSeq Acc Id: NP_038520   ⟸   NM_013492
- Peptide Label: preproprotein
- UniProtKB: Q06890 (UniProtKB/Swiss-Prot),   Q549A5 (UniProtKB/TrEMBL),   Q9JK98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006518567   ⟸   XM_006518504
- Peptide Label: isoform X2
- UniProtKB: Q06890 (UniProtKB/Swiss-Prot),   Q549A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006518566   ⟸   XM_006518503
- Peptide Label: isoform X1
- UniProtKB: Q9JK98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117953   ⟸   ENSMUST00000144619
RefSeq Acc Id: ENSMUSP00000121056   ⟸   ENSMUST00000138665
RefSeq Acc Id: ENSMUSP00000117555   ⟸   ENSMUST00000138191
RefSeq Acc Id: ENSMUSP00000114720   ⟸   ENSMUST00000127387
RefSeq Acc Id: ENSMUSP00000022616   ⟸   ENSMUST00000022616
RefSeq Acc Id: ENSMUSP00000121633   ⟸   ENSMUST00000153460
RefSeq Acc Id: ENSMUSP00000121485   ⟸   ENSMUST00000128539
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06890-F1-model_v2 AlphaFold Q06890 1-448 view protein structure

RGD ID:6824779
Promoter ID:MM_KWN:17264
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain,   ES_Cell,   Liver
Transcripts:OTTMUST00000081231,   OTTMUST00000081417,   OTTMUST00000081418
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,587,281 - 66,587,781 (+)MPROMDB
RGD ID:6824780
Promoter ID:MM_KWN:17265
SO ACC ID:SO:0000170
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,587,561 - 66,588,557 (+)MPROMDB
RGD ID:6824781
Promoter ID:MM_KWN:17266
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000081399,   OTTMUST00000081400,   OTTMUST00000081401,   OTTMUST00000081406
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,588,546 - 66,589,046 (+)MPROMDB
RGD ID:6849025
Promoter ID:MM_XEF:2297
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Transcripts:NM_173902,   NM_213971
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,591,996 - 66,592,496 (+)MPROMDB
RGD ID:6824782
Promoter ID:MM_KWN:17267
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain,   Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,593,471 - 66,593,971 (+)MPROMDB
RGD ID:6848637
Promoter ID:MM_TRO:3178
SO ACC ID:SO:0000170
Tissues & Cell Lines:Liver
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,594,446 - 66,594,946 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88423 AgrOrtholog
Ensembl Genes ENSMUSG00000022037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000022616 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114720.2 UniProtKB/TrEMBL
  ENSMUSP00000117555.2 UniProtKB/TrEMBL
  ENSMUSP00000117953.2 UniProtKB/TrEMBL
  ENSMUSP00000121056.2 UniProtKB/TrEMBL
  ENSMUSP00000121485.2 UniProtKB/TrEMBL
  ENSMUSP00000121633.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022616 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000127387.8 UniProtKB/TrEMBL
  ENSMUST00000128539.8 UniProtKB/TrEMBL
  ENSMUST00000138191.8 UniProtKB/TrEMBL
  ENSMUST00000138665.2 UniProtKB/TrEMBL
  ENSMUST00000144619.2 UniProtKB/TrEMBL
  ENSMUST00000153460.8 UniProtKB/TrEMBL
InterPro Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clusterin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10970:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clu PhenoGen
PIRSF Clusterin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLUSTERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CLUS_MOUSE UniProtKB/Swiss-Prot