Myl7 (myosin, light polypeptide 7, regulatory) - Rat Genome Database

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Gene: Myl7 (myosin, light polypeptide 7, regulatory) Mus musculus
Analyze
Symbol: Myl7
Name: myosin, light polypeptide 7, regulatory
RGD ID: 1317935
MGI Page MGI
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in cardiac muscle tissue development and heart contraction. Located in dendritic spine. Is expressed in several structures, including gastrocnemius muscle; heart; liver; uterus; and vascular system. Orthologous to human MYL7 (myosin light chain 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MLC; MLC-2; MLC-2a; MLC-2alpha; MLC2a; MYL2A; Mylc; Mylc2a; myosin light chain 2a; myosin light chain, regulatory A; myosin regulatory light chain 2, atrial isoform; myosin regulatory light chain 7; RL; RLC-A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,846,637 - 5,848,782 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,846,637 - 5,848,782 (-)EnsemblGRCm39 Ensembl
GRCm38115,896,637 - 5,898,782 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,896,637 - 5,898,782 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,796,640 - 5,798,785 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,796,639 - 5,798,782 (-)NCBIMGSCv36mm8
Celera116,388,472 - 6,390,617 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
4. An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Nishigaki R, etal., Biochem Biophys Res Commun. 2002 Jul 5;295(1):112-8.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:4942892   PMID:7628699   PMID:7638202   PMID:8076526   PMID:8207020   PMID:8777429   PMID:8823298   PMID:9097020   PMID:9136932   PMID:9136933   PMID:9171826   PMID:9422794  
PMID:9425147   PMID:9428411   PMID:9500550   PMID:9500551   PMID:9758703   PMID:9811571   PMID:9876177   PMID:9892427   PMID:10079236   PMID:10349636   PMID:10441370   PMID:10446263  
PMID:10679931   PMID:10807864   PMID:10809671   PMID:10892744   PMID:11042159   PMID:11076861   PMID:11090542   PMID:11124527   PMID:11164852   PMID:11208532   PMID:11217851   PMID:11238910  
PMID:11245568   PMID:11390666   PMID:11437454   PMID:11572777   PMID:11668599   PMID:11784028   PMID:11786513   PMID:11830573   PMID:11884616   PMID:11923873   PMID:12122109   PMID:12297046  
PMID:12466851   PMID:12477932   PMID:14573518   PMID:14667410   PMID:15042700   PMID:15073151   PMID:15158141   PMID:15361625   PMID:15459098   PMID:15464586   PMID:15489334   PMID:15601824  
PMID:15601854   PMID:15663482   PMID:15680351   PMID:15767668   PMID:15843407   PMID:15843414   PMID:15861408   PMID:15870258   PMID:15901664   PMID:15902305   PMID:16141072   PMID:16141073  
PMID:16314518   PMID:16352730   PMID:16554359   PMID:16602821   PMID:16649168   PMID:16680724   PMID:16709898   PMID:16873717   PMID:17234970   PMID:17332425   PMID:17372176   PMID:17441204  
PMID:17468400   PMID:17519332   PMID:17556662   PMID:17720695   PMID:17875930   PMID:17947796   PMID:17954558   PMID:18000065   PMID:18265012   PMID:18328475   PMID:18480752   PMID:18554416  
PMID:18784615   PMID:18973680   PMID:19035347   PMID:19097191   PMID:20071345   PMID:20139090   PMID:20159597   PMID:20167925   PMID:20651287   PMID:20658695   PMID:20824138   PMID:20890042  
PMID:20929948   PMID:21177343   PMID:21267068   PMID:21350214   PMID:21382375   PMID:21399557   PMID:21664901   PMID:21822279   PMID:21873635   PMID:21983003   PMID:22012595   PMID:22090424  
PMID:22116936   PMID:22144571   PMID:22155005   PMID:22158708   PMID:22308401   PMID:22403008   PMID:22826212   PMID:22863011   PMID:22955731   PMID:23063798   PMID:23501471   PMID:23725765  
PMID:23747598   PMID:23974038   PMID:24004946   PMID:24307303   PMID:24680892   PMID:24831012   PMID:24835278   PMID:24996922   PMID:25299188   PMID:25300579   PMID:25986147   PMID:25987543  
PMID:26204127   PMID:26295701   PMID:26321200   PMID:26340748   PMID:26390289   PMID:26469858   PMID:26493106   PMID:26545946   PMID:26822476   PMID:27333774   PMID:27580238   PMID:27841876  
PMID:28114272   PMID:28172500   PMID:28287088   PMID:28512107   PMID:28637870   PMID:29367466   PMID:29374072   PMID:29444209   PMID:29700121   PMID:30012423   PMID:30787001   PMID:30796970  
PMID:30920727   PMID:31042497   PMID:31138536   PMID:31318315   PMID:31318321   PMID:32883967   PMID:33225722   PMID:34062094   PMID:34190686   PMID:34618403   PMID:34854218   PMID:34915728  
PMID:35099001   PMID:36108627   PMID:36413948   PMID:37633271  


Genomics

Comparative Map Data
Myl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,846,637 - 5,848,782 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,846,637 - 5,848,782 (-)EnsemblGRCm39 Ensembl
GRCm38115,896,637 - 5,898,782 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,896,637 - 5,898,782 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,796,640 - 5,798,785 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,796,639 - 5,798,782 (-)NCBIMGSCv36mm8
Celera116,388,472 - 6,390,617 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.88NCBI
MYL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,138,864 - 44,141,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,138,864 - 44,141,332 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,178,463 - 44,180,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,144,988 - 44,147,441 (-)NCBINCBI36Build 36hg18NCBI36
Build 34743,951,704 - 43,954,156NCBI
Celera744,276,421 - 44,278,875 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,063,733 - 44,066,187 (-)NCBIHuRef
CHM1_1744,182,316 - 44,184,770 (-)NCBICHM1_1
T2T-CHM13v2.0744,297,418 - 44,302,609 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,217,962 - 44,220,416 (-)NCBI
Myl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,994,644 - 84,997,173 (-)NCBIGRCr8
mRatBN7.21480,780,684 - 80,783,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,779,776 - 80,783,244 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,182,767 - 85,184,747 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,422,863 - 86,424,843 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,872,177 - 82,874,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,144,770 - 86,147,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,143,862 - 86,147,553 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,828,588 - 86,830,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,568,142 - 86,570,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,587,287 - 86,590,077 (-)NCBI
Celera1479,665,056 - 79,667,036 (-)NCBICelera
Cytogenetic Map14q21NCBI
Myl7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,840,078 - 7,842,129 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,840,078 - 7,842,065 (+)NCBIChiLan1.0ChiLan1.0
MYL7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,050,383 - 49,053,687 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,375,123 - 97,378,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,853,215 - 44,855,728 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,920,572 - 44,923,070 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,920,572 - 44,923,070 (-)Ensemblpanpan1.1panPan2
MYL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,077,358 - 2,079,528 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,782,426 - 14,784,596 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,779,448 - 14,784,595 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,413,649 - 14,415,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,394,122 - 14,396,292 (+)NCBIUU_Cfam_GSD_1.0
Myl7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,888,255 - 99,892,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,100,029 - 19,102,199 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,099,991 - 19,101,985 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,526,045 - 14,528,498 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,525,637 - 14,528,513 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,986,634 - 7,992,117 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,887,747 - 7,889,666 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,887,715 - 7,889,666 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myl7
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:114
Interacting mature miRNAs:115
Transcripts:ENSMUST00000102921
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse

Markers in Region
Mylc2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,896,759 - 5,898,189UniSTSGRCm38
MGSCv37115,796,762 - 5,798,192UniSTSGRCm37
Celera116,388,594 - 6,390,024UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.75UniSTS
RH130995  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,897,134 - 5,898,229UniSTSGRCm38
MGSCv37115,797,137 - 5,798,232UniSTSGRCm37
Celera116,388,969 - 6,390,064UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.75UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000102921   ⟹   ENSMUSP00000099985
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,846,637 - 5,848,782 (-)Ensembl
GRCm38.p6 Ensembl115,896,637 - 5,898,782 (-)Ensembl
RefSeq Acc Id: NM_022879   ⟹   NP_075017
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,846,637 - 5,848,782 (-)NCBI
GRCm38115,896,637 - 5,898,782 (-)ENTREZGENE
MGSCv37115,796,640 - 5,798,785 (-)RGD
Celera116,388,472 - 6,390,617 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_075017 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB31016 (Get FASTA)   NCBI Sequence Viewer  
  AAF76860 (Get FASTA)   NCBI Sequence Viewer  
  AAH61100 (Get FASTA)   NCBI Sequence Viewer  
  BAE27380 (Get FASTA)   NCBI Sequence Viewer  
  EDL40566 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000099985
  ENSMUSP00000099985.4
GenBank Protein Q9QVP4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075017   ⟸   NM_022879
- UniProtKB: Q63977 (UniProtKB/Swiss-Prot),   Q9JIE8 (UniProtKB/Swiss-Prot),   Q9QVP4 (UniProtKB/Swiss-Prot),   Q5SVI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000099985   ⟸   ENSMUST00000102921
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QVP4-F1-model_v2 AlphaFold Q9QVP4 1-175 view protein structure

Promoters
RGD ID:6821367
Promoter ID:MM_KWN:6328
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_022879
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36115,798,261 - 5,798,761 (-)MPROMDB
RGD ID:8673870
Promoter ID:EPDNEW_M14965
Type:single initiation site
Name:Myl7_1
Description:Mus musculus myosin, light polypeptide 7, regulatory , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38115,898,778 - 5,898,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107495 AgrOrtholog
Ensembl Genes ENSMUSG00000020469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000102921 ENTREZGENE
  ENSMUST00000102921.4 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17898 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107495 ENTREZGENE
NCBI Gene 17898 ENTREZGENE
PANTHER MYOSIN REGULATORY LIGHT CHAIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOSIN REGULATORY LIGHT CHAIN 2, ATRIAL ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myl7 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MLRA_MOUSE UniProtKB/Swiss-Prot
  Q5SVI8 ENTREZGENE, UniProtKB/TrEMBL
  Q63977 ENTREZGENE
  Q9JIE8 ENTREZGENE
  Q9QVP4 ENTREZGENE
UniProt Secondary Q63977 UniProtKB/Swiss-Prot
  Q9JIE8 UniProtKB/Swiss-Prot