Npr1 (natriuretic peptide receptor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Npr1 (natriuretic peptide receptor 1) Mus musculus
Analyze
Symbol: Npr1
Name: natriuretic peptide receptor 1
RGD ID: 11007
MGI Page MGI
Description: Enables guanylate cyclase activity. Involved in regulation of blood pressure. Acts upstream of or within cGMP biosynthetic process. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and respiratory system. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI893888; ANP-A; ANPR-A; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor type A; GC-; GC-A; guanylate cyclase A; guanylyl cyclase-A; MGC117511; N; Nppa receptor; NPR-A; NPRA; Pndr
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,357,898 - 90,373,235 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,357,898 - 90,373,173 (-)EnsemblGRCm39 Ensembl
GRCm38390,450,591 - 90,465,928 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,450,591 - 90,465,866 (-)EnsemblGRCm38mm10GRCm38
MGSCv37390,254,514 - 90,269,788 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,536,519 - 90,552,265 (-)NCBIMGSCv36mm8
Celera390,488,131 - 90,503,567 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations. Bryan PM, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1636-44. Epub 2007 Jan 30.
2. Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy. Christoffersen TE, etal., Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1635-41. Epub 2005 Nov 4.
3. Novel NPR1 polymorphic variants and its exclusion as a candidate gene for medullary cystic kidney disease (ADMCKD) type 1. Koptides M, etal., Mol Cell Probes. 2001 Dec;15(6):357-61.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Missense mutation of exon 3 in the type A human natriuretic peptide receptor gene is associated with myocardial infarction. Nakayama T, etal., Med Sci Monit. 2003 Dec;9(12):CR505-10.
8. Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Nishikimi T, etal., Regul Pept. 2009 Apr 10;154(1-3):44-53. doi: 10.1016/j.regpep.2009.02.006. Epub 2009 Feb 15.
9. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Oliver PM, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype. Pitzalis MV, etal., J Hypertens. 2003 Aug;21(8):1491-6.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides. Sorci G, etal., Brain Res. 1995 Jun 12;683(1):51-8.
15. TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus. Tremblay J, etal., Hypertension 2003 Jan;41(1):16-24.
Additional References at PubMed
PMID:1973687   PMID:7477288   PMID:7558020   PMID:7838126   PMID:7902087   PMID:7949740   PMID:9287305   PMID:9482923   PMID:9560157   PMID:9950655   PMID:10092664   PMID:10349636  
PMID:10405217   PMID:10520994   PMID:10537139   PMID:10556287   PMID:10760303   PMID:10964718   PMID:11014237   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11226303   PMID:11306601  
PMID:11416031   PMID:11457873   PMID:11513736   PMID:11553513   PMID:11748047   PMID:11821394   PMID:11997476   PMID:12095686   PMID:12124219   PMID:12270869   PMID:12466851   PMID:12477932  
PMID:12637561   PMID:12702516   PMID:12727932   PMID:12824076   PMID:14500707   PMID:14592959   PMID:14610273   PMID:14681479   PMID:14978280   PMID:15093694   PMID:15135664   PMID:15191892  
PMID:15196958   PMID:15287002   PMID:15337836   PMID:15629436   PMID:15710627   PMID:15769452   PMID:15778276   PMID:15793309   PMID:15911610   PMID:15931395   PMID:15939815   PMID:15998711  
PMID:16141072   PMID:16141073   PMID:16216978   PMID:16430226   PMID:16517010   PMID:16602821   PMID:16930545   PMID:17267074   PMID:17293444   PMID:17389676   PMID:17510245   PMID:17566078  
PMID:17848634   PMID:17954614   PMID:18172317   PMID:18223163   PMID:18367637   PMID:18443239   PMID:18450968   PMID:18601931   PMID:18651838   PMID:18713751   PMID:18766159   PMID:18799693  
PMID:19346456   PMID:19372206   PMID:19436108   PMID:19487584   PMID:19487812   PMID:19628785   PMID:19690065   PMID:19782130   PMID:19805191   PMID:19828462   PMID:19855088   PMID:19906950  
PMID:19906978   PMID:19948658   PMID:20039448   PMID:20098992   PMID:20150880   PMID:20448219   PMID:20540624   PMID:20543084   PMID:20555029   PMID:20649600   PMID:20864529   PMID:20881240  
PMID:21267068   PMID:21366551   PMID:21390061   PMID:21677750   PMID:21809340   PMID:21873635   PMID:22001395   PMID:22025581   PMID:22027011   PMID:22318993   PMID:22610792   PMID:22652704  
PMID:23020941   PMID:23071870   PMID:23188418   PMID:23195629   PMID:23233529   PMID:23324181   PMID:23382219   PMID:23464624   PMID:23533187   PMID:23814119   PMID:24424043   PMID:24451378  
PMID:24615855   PMID:24717731   PMID:24837433   PMID:26059418   PMID:26253614   PMID:26377794   PMID:26517044   PMID:26934489   PMID:27142162   PMID:27153922   PMID:27199456   PMID:27346147  
PMID:27592451   PMID:27634171   PMID:28378742   PMID:28429785   PMID:28566502   PMID:28864549   PMID:29326144   PMID:29409758   PMID:29472841   PMID:30016962   PMID:30169131   PMID:30943067  
PMID:30965084   PMID:31619060   PMID:31665900   PMID:32032577   PMID:32325033   PMID:32327991   PMID:33039402   PMID:33200806   PMID:33245046   PMID:34260913   PMID:34859913   PMID:34919054  
PMID:34992532   PMID:35013221   PMID:35534926   PMID:35794311   PMID:36232788   PMID:36293483   PMID:36412146   PMID:36618828   PMID:37356621   PMID:38235330  


Genomics

Comparative Map Data
Npr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,357,898 - 90,373,235 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,357,898 - 90,373,173 (-)EnsemblGRCm39 Ensembl
GRCm38390,450,591 - 90,465,928 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,450,591 - 90,465,866 (-)EnsemblGRCm38mm10GRCm38
MGSCv37390,254,514 - 90,269,788 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,536,519 - 90,552,265 (-)NCBIMGSCv36mm8
Celera390,488,131 - 90,503,567 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.23NCBI
NPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,678,688 - 153,693,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,678,688 - 153,693,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371153,651,164 - 153,666,468 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,917,737 - 151,933,088 (+)NCBINCBI36Build 36hg18NCBI36
Build 341150,464,185 - 150,479,536NCBI
Celera1126,722,358 - 126,737,655 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1125,014,421 - 125,029,723 (+)NCBIHuRef
CHM1_11155,047,152 - 155,062,430 (+)NCBICHM1_1
T2T-CHM13v2.01152,815,953 - 152,831,256 (+)NCBIT2T-CHM13v2.0
Npr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,231,766 - 178,247,591 (-)NCBIGRCr8
mRatBN7.22175,934,181 - 175,950,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,934,181 - 175,949,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,074,109 - 183,089,476 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,096,360 - 181,111,730 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,696,310 - 175,711,670 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,840,403 - 189,857,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,840,403 - 189,856,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,271,276 - 209,287,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,724,916 - 182,740,242 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12182,675,021 - 182,690,348 (-)NCBI
Celera2169,869,831 - 169,885,101 (-)NCBICelera
Cytogenetic Map2q34NCBI
Npr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545323,956 - 338,097 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955545323,386 - 338,654 (+)NCBIChiLan1.0ChiLan1.0
NPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,138,643 - 96,160,742 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,873,841 - 95,889,322 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,034,972 - 129,050,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,663,941 - 132,679,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,664,948 - 132,679,327 (+)Ensemblpanpan1.1panPan2
NPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,382,246 - 43,396,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,283,418 - 43,396,027 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,875,275 - 42,888,999 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,331,940 - 43,345,662 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,153,680 - 43,345,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,034,052 - 43,047,778 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,087,306 - 43,101,030 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,370,926 - 43,384,656 (-)NCBIUU_Cfam_GSD_1.0
Npr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,449,225 - 24,465,782 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,480,267 - 3,495,643 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,479,858 - 3,496,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl495,957,228 - 95,973,430 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1495,957,220 - 95,974,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,855,577 - 104,870,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,115,319 - 10,131,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2010,115,105 - 10,131,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660389,492,241 - 9,508,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248853,460,438 - 3,475,720 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248853,462,334 - 3,475,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npr1
350 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1020
Count of miRNA genes:547
Interacting mature miRNAs:656
Transcripts:ENSMUST00000029540, ENSMUST00000124760, ENSMUST00000142243, ENSMUST00000146991, ENSMUST00000152510
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse

Markers in Region
AI893888  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38390,450,668 - 90,450,794UniSTSGRCm38
MGSCv37390,254,590 - 90,254,716UniSTSGRCm37
Celera390,488,207 - 90,488,333UniSTS
Cytogenetic Map3F1UniSTS
cM Map347.6UniSTS
Whitehead/MRC_RH31012.09UniSTS
Npr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38390,457,370 - 90,458,704UniSTSGRCm38
MGSCv37390,261,292 - 90,262,626UniSTSGRCm37
Celera390,495,070 - 90,496,404UniSTS
Cytogenetic Map3F1UniSTS
cM Map347.6UniSTS
cM Map347.6UniSTS
PMC199554P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38390,465,724 - 90,466,012UniSTSGRCm38
MGSCv37390,269,646 - 90,269,934UniSTSGRCm37
Celera390,503,425 - 90,503,707UniSTS
Cytogenetic Map3F1UniSTS
cM Map347.6UniSTS
Npr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
cM Map347.6UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029540   ⟹   ENSMUSP00000029540
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl390,357,898 - 90,373,173 (-)Ensembl
GRCm38.p6 Ensembl390,450,591 - 90,465,866 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124760   ⟹   ENSMUSP00000118023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl390,364,725 - 90,368,728 (-)Ensembl
GRCm38.p6 Ensembl390,457,418 - 90,461,421 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142243
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl390,362,410 - 90,364,783 (-)Ensembl
GRCm38.p6 Ensembl390,455,103 - 90,457,476 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl390,364,706 - 90,366,246 (-)Ensembl
GRCm38.p6 Ensembl390,457,399 - 90,458,939 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl390,358,017 - 90,359,088 (-)Ensembl
GRCm38.p6 Ensembl390,450,710 - 90,451,781 (-)Ensembl
RefSeq Acc Id: NM_008727   ⟹   NP_032753
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39390,357,899 - 90,373,173 (-)NCBI
GRCm38390,450,592 - 90,465,866 (-)NCBI
MGSCv37390,254,514 - 90,269,788 (-)RGD
Celera390,488,131 - 90,503,567 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501114   ⟹   XP_006501177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39390,366,711 - 90,373,235 (-)NCBI
GRCm38390,459,404 - 90,465,928 (-)NCBI
Sequence:
RefSeq Acc Id: XR_375494
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39390,357,898 - 90,373,235 (-)NCBI
GRCm38390,450,591 - 90,465,928 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032753   ⟸   NM_008727
- Peptide Label: precursor
- UniProtKB: P18293 (UniProtKB/Swiss-Prot),   Q2TAY4 (UniProtKB/TrEMBL),   Q91X04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501177   ⟸   XM_006501114
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000118023   ⟸   ENSMUST00000124760
RefSeq Acc Id: ENSMUSP00000029540   ⟸   ENSMUST00000029540
Protein Domains
Guanylate cyclase   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18293-F1-model_v2 AlphaFold P18293 1-1057 view protein structure

Promoters
RGD ID:6834166
Promoter ID:MM_KWN:35030
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Lung,   Spleen
Transcripts:OTTMUST00000073134
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36390,255,276 - 90,256,202 (-)MPROMDB
RGD ID:6834165
Promoter ID:MM_KWN:35032
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000073133
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36390,262,066 - 90,262,566 (-)MPROMDB
RGD ID:6834163
Promoter ID:MM_KWN:35035
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000073130,   OTTMUST00000073135
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36390,269,516 - 90,270,102 (-)MPROMDB
RGD ID:6881340
Promoter ID:EPDNEW_M4121
Type:initiation region
Name:Npr1_1
Description:Mus musculus natriuretic peptide receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38390,465,866 - 90,465,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97371 AgrOrtholog
Ensembl Genes ENSMUSG00000027931 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029540 ENTREZGENE
  ENSMUST00000029540.13 UniProtKB/Swiss-Prot
  ENSMUST00000124760.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANPR/GUC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97371 ENTREZGENE
NCBI Gene 18160 ENTREZGENE
PANTHER ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLYL CYCLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npr1 PhenoGen
PRINTS NATPEPTIDER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANF_RECEPTORS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ANPRA_MOUSE UniProtKB/Swiss-Prot
  F6W125_MOUSE UniProtKB/TrEMBL
  P18293 ENTREZGENE
  Q2TAY4 ENTREZGENE, UniProtKB/TrEMBL
  Q3UY30_MOUSE UniProtKB/TrEMBL
  Q91X04 ENTREZGENE, UniProtKB/TrEMBL