Prkg1 (protein kinase, cGMP-dependent, type I) - Rat Genome Database

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Gene: Prkg1 (protein kinase, cGMP-dependent, type I) Mus musculus
Analyze
Symbol: Prkg1
Name: protein kinase, cGMP-dependent, type I
RGD ID: 1617610
MGI Page MGI
Description: Enables cGMP binding activity and cGMP-dependent protein kinase activity. Involved in collateral sprouting and signal transduction. Acts upstream of or within cGMP-mediated signaling; nervous system development; and relaxation of vascular associated smooth muscle. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including bone; central nervous system; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW125416; cGK 1; cGK1; CGKI; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; Gm19690; MGC132849; predicted gene, 19690; Prkg; Prkg1b; Prkgr1b
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,541,887 - 31,742,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,541,889 - 31,742,433 (-)EnsemblGRCm39 Ensembl
GRCm381930,564,487 - 31,765,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,642,041 - 31,839,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,633,548 - 31,831,030 (-)NCBIMGSCv36mm8
Celera1931,351,778 - 32,553,439 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (EXP)
17alpha-ethynylestradiol  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (ISO)
5-methoxypsoralen  (EXP)
7-NITROINDAZOLE  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
ammonia  (ISO)
apocynin  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calyculin a  (ISO)
captan  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibenziodolium  (ISO)
diethyl malate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
fluoxetine  (ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
glucose  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
KT 5823  (ISO)
lead diacetate  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mevinphos  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitroglycerin  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
sucrose  (ISO)
sulindac sulfone  (ISO)
tadalafil  (EXP)
tamoxifen  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thalidomide  (EXP)
thioacetamide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptorelin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue development  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal brown adipose tissue thermogenesis  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal duodenum morphology  (IEA)
abnormal erythrocyte morphology  (IAGP)
abnormal gastrointestinal motility  (IAGP)
abnormal intestinal peristalsis  (IAGP)
abnormal intestinal transit time  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal long-term depression  (IAGP)
abnormal penile erection  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
anemia  (IAGP)
decreased body surface temperature  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased brown fat cell lipid droplet size  (IAGP)
decreased cardiac output  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fat cell mitochondrial DNA content  (IAGP)
decreased hematocrit  (IAGP)
decreased litter size  (IAGP)
decreased triglyceride level  (IAGP)
decreased vasodilation  (IAGP)
enlarged heart  (IEA)
enlarged spleen  (IAGP)
hypertension  (IAGP)
impaired muscle relaxation  (IAGP)
impaired smooth muscle contractility  (IAGP)
increased erythrocyte clearance  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular volume  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased red blood cell distribution width  (IAGP)
increased startle reflex  (IEA)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality, complete penetrance  (IEA)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
pyloric sphincter hypertrophy  (IAGP)
pyloric stenosis  (IAGP)
reduced female fertility  (IAGP)
reduced long-term potentiation  (IAGP)
reduced male fertility  (IAGP)
reticulocytosis  (IAGP)
salt-resistant hypertension  (IAGP)
stomach fundus hypertrophy  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cells. Andric SA, etal., Biol Reprod. 2010 Sep;83(3):434-42. doi: 10.1095/biolreprod.110.083626. Epub 2010 May 12.
2. Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha. Bivalacqua TJ, etal., BJU Int. 2007 Jun;99(6):1488-94. Epub 2007 Mar 12.
3. Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. Gerzanich V, etal., Circ Res. 2003 Oct 31;93(9):805-12. Epub 2003 Sep 25.
4. Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. Giricz Z, etal., Br J Pharmacol. 2009 Nov;158(6):1495-502. doi: 10.1111/j.1476-5381.2009.00424.x. Epub 2009 Oct 20.
5. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Jaumann M, etal., Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.
6. Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Maas O, etal., Br J Pharmacol. 2008 May;154(1):25-31. doi: 10.1038/bjp.2008.71. Epub 2008 Mar 10.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Insulin increases glomerular filtration barrier permeability through dimerization of protein kinase G type Ialpha subunits. Piwkowska A, etal., Biochim Biophys Acta. 2013 Jun;1832(6):791-804. doi: 10.1016/j.bbadis.2013.02.011. Epub 2013 Feb 21.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Elevated guanylate cyclase and cyclic-guanosine monophosphate-dependent protein kinase levels in nasal mucosae of antigen-challenged rats. Sakai H, etal., Microvasc Res. 2013 Nov;90:150-3. doi: 10.1016/j.mvr.2013.08.009. Epub 2013 Sep 5.
15. Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase. Soro-Paavonen A, etal., J Hypertens. 2010 Apr;28(4):780-8. doi: 10.1097/HJH.0b013e328335043e.
16. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Tegeder I, etal., Neurosci Lett. 2002 Oct 31;332(2):146-50.
17. Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Tegeder I, etal., Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3253-7. Epub 2004 Feb 18.
18. Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat. Zanetti M, etal., Atherosclerosis. 2005 Jul;181(1):69-73. Epub 2005 Feb 12.
Additional References at PubMed
PMID:8514791   PMID:8889548   PMID:8953039   PMID:9606187   PMID:9788971   PMID:9870937   PMID:10085070   PMID:10209042   PMID:10349636   PMID:10454212   PMID:10671526   PMID:10688876  
PMID:10694248   PMID:10922068   PMID:10956273   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11786513   PMID:12371625   PMID:12417579   PMID:12466851   PMID:12477932   PMID:12526795  
PMID:12621153   PMID:12853418   PMID:14568994   PMID:14597716   PMID:14610087   PMID:14610273   PMID:15115753   PMID:15280395   PMID:15388327   PMID:15465019   PMID:15483626   PMID:15505114  
PMID:16034136   PMID:16107711   PMID:16141072   PMID:16141073   PMID:16154207   PMID:16154279   PMID:16167338   PMID:16430226   PMID:16533816   PMID:16920709   PMID:16920816   PMID:16990611  
PMID:17105400   PMID:17420342   PMID:17878170   PMID:17901360   PMID:17954614   PMID:17991884   PMID:18256252   PMID:18420996   PMID:18443297   PMID:18448676   PMID:18535260   PMID:18685080  
PMID:18723505   PMID:18799693   PMID:19008225   PMID:19127022   PMID:19156199   PMID:19168131   PMID:19193882   PMID:19287493   PMID:19424179   PMID:19457107   PMID:19487814   PMID:19628652  
PMID:19737918   PMID:19805191   PMID:19952371   PMID:19955367   PMID:19961855   PMID:20018259   PMID:20023176   PMID:20060325   PMID:20164378   PMID:20171263   PMID:20212138   PMID:20352235  
PMID:20410120   PMID:20453163   PMID:20456015   PMID:20498039   PMID:20691687   PMID:20930715   PMID:20978093   PMID:21267068   PMID:21328456   PMID:21464444   PMID:21677750   PMID:21873635  
PMID:21914444   PMID:22027011   PMID:22160771   PMID:22199120   PMID:22203739   PMID:22245782   PMID:22253479   PMID:22427743   PMID:22503686   PMID:22632818   PMID:22922339   PMID:23006734  
PMID:23066013   PMID:23285278   PMID:23303211   PMID:23407708   PMID:23535651   PMID:23612967   PMID:23657971   PMID:23686857   PMID:23716652   PMID:23755100   PMID:23760283   PMID:23770744  
PMID:23788765   PMID:23814119   PMID:23825069   PMID:23832809   PMID:24095868   PMID:24194600   PMID:24375799   PMID:24401847   PMID:24431432   PMID:24449818   PMID:24550112   PMID:24573388  
PMID:24837433   PMID:24872318   PMID:25128522   PMID:25139994   PMID:25152402   PMID:25301187   PMID:25447536   PMID:25586176   PMID:25900831   PMID:25938783   PMID:25978317   PMID:26124274  
PMID:26178595   PMID:26183401   PMID:26830212   PMID:26930384   PMID:27142162   PMID:27342776   PMID:27729550   PMID:27782102   PMID:28062507   PMID:28280239   PMID:28326941   PMID:28360102  
PMID:28690194   PMID:28705804   PMID:29054855   PMID:29472841   PMID:29962937   PMID:30104414   PMID:30152261   PMID:30249793   PMID:30275816   PMID:30319353   PMID:30327468   PMID:30760924  
PMID:31186362   PMID:31372656   PMID:31387997   PMID:31423931   PMID:32315291   PMID:32325033   PMID:33291075   PMID:34576086   PMID:34863181  


Genomics

Comparative Map Data
Prkg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,541,887 - 31,742,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,541,889 - 31,742,433 (-)EnsemblGRCm39 Ensembl
GRCm381930,564,487 - 31,765,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,642,041 - 31,839,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,633,548 - 31,831,030 (-)NCBIMGSCv36mm8
Celera1931,351,778 - 32,553,439 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.17NCBI
PRKG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1050,990,888 - 52,298,423 (+)EnsemblGRCh38hg38GRCh38
GRCh371052,750,648 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBICelera
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
T2T-CHM13v2.01051,839,480 - 53,144,930 (+)NCBIT2T-CHM13v2.0
Prkg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,818,950 - 239,052,184 (-)NCBIGRCr8
mRatBN7.21228,409,605 - 229,638,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,408,947 - 229,639,080 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,778,127 - 238,005,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,707,829 - 244,934,964 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,538,254 - 237,776,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Celera1225,545,145 - 226,760,176 (-)NCBICelera
Cytogenetic Map1q52NCBI
Prkg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554256,176,432 - 7,331,446 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554256,176,335 - 7,335,867 (+)NCBIChiLan1.0ChiLan1.0
PRKG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2863,299,984 - 64,595,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11063,306,357 - 64,600,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01047,642,312 - 48,935,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11049,778,821 - 51,069,314 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1049,779,211 - 51,064,882 (+)Ensemblpanpan1.1panPan2
PRKG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12635,732,974 - 36,932,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,737,242 - 36,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2635,620,229 - 36,818,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02637,271,288 - 38,465,630 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,275,477 - 38,465,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,169,158 - 36,367,548 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,756,074 - 35,955,695 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,996,645 - 37,196,072 (-)NCBIUU_Cfam_GSD_1.0
Prkg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,309,475 - 76,469,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787332,342 - 1,491,285 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,558,533 - 98,793,010 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,558,531 - 98,793,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,256,149 - 107,028,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.214107,499,623 - 107,663,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,858,269 - 80,188,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604839,812,502 - 40,750,048 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479111,338,510 - 12,654,812 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479111,334,146 - 12,656,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkg1
42021 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:887
Count of miRNA genes:477
Interacting mature miRNAs:532
Transcripts:ENSMUST00000065067, ENSMUST00000073581, ENSMUST00000182401, ENSMUST00000182459, ENSMUST00000182527, ENSMUST00000182685, ENSMUST00000183135
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse

Markers in Region
AW125416  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,568,887 - 30,569,005UniSTSGRCm38
MGSCv371930,643,377 - 30,643,495UniSTSGRCm37
Celera1931,353,114 - 31,353,232UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19305.86UniSTS
39.MMHAP81FRE12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,763,366 - 31,763,564UniSTSGRCm38
MGSCv371931,837,856 - 31,838,054UniSTSGRCm37
Celera1932,551,772 - 32,551,970UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19316.83UniSTS
Cstf2t  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,084,316 - 31,084,915UniSTSGRCm38
MGSCv371931,158,806 - 31,159,405UniSTSGRCm37
Celera1931,868,919 - 31,869,518UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19C1UniSTS
cM Map19 UniSTS
37.MMHAP12FRE10.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,406,242 - 31,406,412UniSTSGRCm38
MGSCv371931,480,732 - 31,480,902UniSTSGRCm37
Celera1932,190,698 - 32,190,868UniSTS
Cytogenetic Map19C2UniSTS
Whitehead_YAC19 UniSTS
42.MMHAP53FRF12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,244,041 - 31,244,200UniSTSGRCm38
MGSCv371931,318,531 - 31,318,690UniSTSGRCm37
Celera1932,028,817 - 32,028,976UniSTS
Cytogenetic Map19C2UniSTS
Whitehead_YAC2 UniSTS
UniSTS:237921  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,397,201 - 31,397,343UniSTSGRCm38
MGSCv371931,471,691 - 31,471,833UniSTSGRCm37
Celera1932,181,929 - 32,182,071UniSTS
Cytogenetic Map19C2UniSTS
RH126283  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,085,644 - 31,085,859UniSTSGRCm38
MGSCv371931,160,134 - 31,160,349UniSTSGRCm37
Celera1931,870,247 - 31,870,462UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19306.86UniSTS
RH126423  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,649,317 - 31,649,534UniSTSGRCm38
MGSCv371931,723,807 - 31,724,024UniSTSGRCm37
Celera1932,437,968 - 32,438,185UniSTS
Cytogenetic Map19C2UniSTS
cM Map19 UniSTS
Whitehead/MRC_RH19315.99UniSTS
AI843588  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,341,300 - 31,341,426UniSTSGRCm38
MGSCv371931,415,790 - 31,415,916UniSTSGRCm37
Celera1932,125,980 - 32,126,106UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19310.59UniSTS
UniSTS:224590  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,509,556 - 31,509,710UniSTSGRCm38
GRCm38724,458,133 - 24,458,271UniSTSGRCm38
MGSCv371931,584,046 - 31,584,200UniSTSGRCm37
MGSCv37725,243,152 - 25,243,290UniSTSGRCm37
Celera1932,298,288 - 32,298,442UniSTS
Cytogenetic Map19C2UniSTS
UniSTS:224999  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,875,116 - 30,875,293UniSTSGRCm38
MGSCv371930,949,606 - 30,949,783UniSTSGRCm37
Celera1931,659,465 - 31,659,642UniSTS
Cytogenetic Map19C2UniSTS
Prkg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381931,764,554 - 31,764,826UniSTSGRCm38
MGSCv371931,839,044 - 31,839,316UniSTSGRCm37
Celera1932,552,960 - 32,553,232UniSTS
Cytogenetic Map19C2UniSTS
cM Map19 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC119158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC157907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ258300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000065067   ⟹   ENSMUSP00000067576
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,541,889 - 31,742,433 (-)Ensembl
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)Ensembl
RefSeq Acc Id: ENSMUST00000073581   ⟹   ENSMUSP00000073268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,545,947 - 31,641,770 (-)Ensembl
GRCm38.p6 Ensembl1930,568,547 - 31,664,370 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182401
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,686,285 - 30,758,852 (-)Ensembl
GRCm38.p6 Ensembl1930,708,885 - 30,781,452 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182459   ⟹   ENSMUSP00000158419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,546,363 - 30,551,555 (-)Ensembl
GRCm38.p6 Ensembl1930,568,963 - 30,574,155 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182527
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,596,771 - 30,602,891 (-)Ensembl
GRCm38.p6 Ensembl1930,619,371 - 30,625,491 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1931,719,514 - 31,742,373 (-)Ensembl
GRCm38.p6 Ensembl1931,742,114 - 31,764,973 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183135
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,546,361 - 30,551,555 (-)Ensembl
GRCm38.p6 Ensembl1930,568,961 - 30,574,155 (-)Ensembl
RefSeq Acc Id: ENSMUST00000239061   ⟹   ENSMUSP00000159122
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,545,427 - 30,707,982 (-)Ensembl
GRCm38.p6 Ensembl1930,568,027 - 30,730,582 (-)Ensembl
RefSeq Acc Id: NM_001013833   ⟹   NP_001013855
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,541,887 - 31,742,433 (-)NCBI
GRCm381930,564,487 - 31,765,033 (-)NCBI
MGSCv371930,642,041 - 31,839,523 (-)RGD
Celera1931,348,899 - 32,553,439 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001411181   ⟹   NP_001398110
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,541,887 - 31,742,675 (-)NCBI
RefSeq Acc Id: NM_011160   ⟹   NP_035290
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,541,887 - 31,641,770 (-)NCBI
GRCm381930,564,487 - 31,664,370 (-)NCBI
MGSCv371930,642,041 - 31,839,523 (-)RGD
Celera1931,348,899 - 32,553,439 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001013855   ⟸   NM_001013833
- Peptide Label: isoform alpha
- UniProtKB: Q14DK6 (UniProtKB/Swiss-Prot),   Q9Z0Z0 (UniProtKB/Swiss-Prot),   P0C605 (UniProtKB/Swiss-Prot),   Q8BND1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_035290   ⟸   NM_011160
- Peptide Label: isoform beta
- UniProtKB: P0C605 (UniProtKB/Swiss-Prot),   Q8BND1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000067576   ⟸   ENSMUST00000065067
RefSeq Acc Id: ENSMUSP00000073268   ⟸   ENSMUST00000073581
RefSeq Acc Id: ENSMUSP00000159122   ⟸   ENSMUST00000239061
RefSeq Acc Id: ENSMUSP00000158419   ⟸   ENSMUST00000182459
RefSeq Acc Id: NP_001398110   ⟸   NM_001411181
- Peptide Label: isoform alpha
- UniProtKB: Q14DK6 (UniProtKB/Swiss-Prot),   P0C605 (UniProtKB/Swiss-Prot),   Q9Z0Z0 (UniProtKB/Swiss-Prot),   Q8BND1 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C605-F1-model_v2 AlphaFold P0C605 1-671 view protein structure

Promoters
RGD ID:6830332
Promoter ID:MM_KWN:26835
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:UC008HEO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361931,738,601 - 31,739,212 (-)MPROMDB
RGD ID:13679252
Promoter ID:EPDNEW_M23776
Type:initiation region
Name:Prkg1_1
Description:Mus musculus protein kinase, cGMP-dependent, type I , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381931,765,007 - 31,765,067EPDNEW
RGD ID:6830331
Promoter ID:MM_KWN:26836
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:NM_001013833
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361931,839,421 - 31,839,921 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108174 AgrOrtholog
Ensembl Genes ENSMUSG00000052920 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065067 ENTREZGENE
  ENSMUST00000065067.14 UniProtKB/Swiss-Prot
  ENSMUST00000073581 ENTREZGENE
  ENSMUST00000073581.6 UniProtKB/Swiss-Prot
  ENSMUST00000182459.2 UniProtKB/TrEMBL
  ENSMUST00000239061.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cGMP_dep_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_cGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108174 ENTREZGENE
NCBI Gene 19091 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN KINASE CGMP-DEPENDENT 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PhenoGen Prkg1 PhenoGen
PIRSF cGMP-dep_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CGMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BB87_MOUSE UniProtKB/TrEMBL
  A0A5F8MPU4_MOUSE UniProtKB/TrEMBL
  KGP1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q14DK6 ENTREZGENE
  Q8BND1 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0Z0 ENTREZGENE
UniProt Secondary Q14DK6 UniProtKB/Swiss-Prot
  Q9Z0Z0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Prkg1  protein kinase, cGMP-dependent, type I  Gm19690  predicted gene, 19690  Data merged from RGD:5140278 737654 PROVISIONAL