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Gene: PRKG1 (protein kinase cGMP-dependent 1) Homo sapiens
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Symbol: PRKG1
Name: protein kinase cGMP-dependent 1
Description: Exhibits cGMP-dependent protein kinase activity; calcium channel regulator activity; and identical protein binding activity. Involved in several processes, including negative regulation of platelet aggregation; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular smooth muscle cell proliferation. Localizes to the cytoplasm and plasma membrane. Implicated in thoracic aortic aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1; AAT8; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; DKFZp686K042; FLJ36117; MGC71944; PGK; PKG; PKG1; PRKG1B; PRKGR1B; protein kinase, cGMP-dependent, regulatory, type I, beta
Orthologs:
Mus musculus (house mouse) : Prkg1 (protein kinase, cGMP-dependent, type I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkg1 (protein kinase cGMP-dependent 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkg1 (protein kinase cGMP-dependent 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKG1 (protein kinase cGMP-dependent 1)
Canis lupus familiaris (dog) : PRKG1 (protein kinase cGMP-dependent 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkg1 (protein kinase cGMP-dependent 1)
Sus scrofa (pig) : PRKG1 (protein kinase cGMP-dependent 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371052,750,911 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBINCBI36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBI
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PRKG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322442
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.