PRKG1 (protein kinase cGMP-dependent 1) - Rat Genome Database
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Gene: PRKG1 (protein kinase cGMP-dependent 1) Sus scrofa
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Symbol: PRKG1
Name: protein kinase cGMP-dependent 1
RGD ID: 13934691
Description: ENCODES a protein that exhibits identical protein binding (ortholog); mitogen-activated protein kinase p38 binding (ortholog); protein kinase activity (ortholog); INVOLVED IN brain development (ortholog); cell growth involved in cardiac muscle cell development (ortholog); cerebellum development (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ASSOCIATED WITH allergic rhinitis (ortholog); amphetamine abuse (ortholog); connective tissue disease (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 3',5'-cyclic GMP; nitroglycerin; superoxide
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cGMP-dependent protein kinase 1; cGMP-dependent protein kinase type I beta; Prkg1beta; protein kinase, cGMP-dependent, type I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,560,785 - 98,793,318 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,558,531 - 98,793,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,256,149 - 107,028,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.214107,499,623 - 107,663,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16326756  


Genomics

Comparative Map Data
PRKG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,560,785 - 98,793,318 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11497,558,531 - 98,793,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,256,149 - 107,028,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.214107,499,623 - 107,663,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1050,990,888 - 52,298,423 (+)EnsemblGRCh38hg38GRCh38
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371052,750,911 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBINCBI36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBI
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
Prkg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,541,887 - 31,742,667 (-)NCBIGRCm39mm39
GRCm381930,564,487 - 31,765,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,642,041 - 31,839,523 (-)NCBIGRCm37mm9NCBIm37
MGSCv361930,633,548 - 31,831,030 (-)NCBImm8
Celera1931,351,778 - 32,553,439 (-)NCBICelera
Cytogenetic Map19C1NCBI
Prkg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Celera1225,545,145 - 226,760,176 (-)NCBICelera
Cytogenetic Map1q52NCBI
Prkg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554256,176,432 - 7,331,446 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554256,176,335 - 7,335,867 (+)NCBIChiLan1.0ChiLan1.0
PRKG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11049,778,821 - 51,069,314 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1049,779,211 - 51,064,882 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01047,642,312 - 48,935,188 (+)NCBIMhudiblu_PPA_v0panPan3
PRKG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2635,737,242 - 36,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12635,732,974 - 36,932,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prkg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,858,269 - 80,188,163 (-)NCBI
Prkg1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479111,334,146 - 12,656,480 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 1
Low 8 4 3 5 2 22 2 2 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011414   ⟹   ENSSSCP00000011118
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1497,560,785 - 98,793,318 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053831   ⟹   ENSSSCP00000041950
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1497,560,785 - 98,711,610 (-)Ensembl
RefSeq Acc Id: NM_001044574   ⟹   NP_001038039
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11497,562,710 - 98,793,080 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021072187   ⟹   XP_020927846
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11497,558,531 - 98,711,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021072188   ⟹   XP_020927847
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11497,558,631 - 98,711,158 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001038039 (Get FASTA)   NCBI Sequence Viewer  
  XP_020927846 (Get FASTA)   NCBI Sequence Viewer  
  XP_020927847 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAZ75707 (Get FASTA)   NCBI Sequence Viewer  
  ABJ74168 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020927846   ⟸   XM_021072187
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020927847   ⟸   XM_021072188
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001038039   ⟸   NM_001044574
- UniProtKB: Q3YJM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011118   ⟸   ENSSSCT00000011414
RefSeq Acc Id: ENSSSCP00000041950   ⟸   ENSSSCT00000053831

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010429 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022246 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011118 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000041950 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070037296 UniProtKB/TrEMBL
  ENSSSCP00070037302 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011414 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053831 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070044266 UniProtKB/TrEMBL
  ENSSSCT00070044272 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  cGMP_dep_kinase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_cGK UniProtKB/TrEMBL
KEGG Report ssc:733640 UniProtKB/TrEMBL
NCBI Gene PRKG1 ENTREZGENE
Pfam cNMP_binding UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PIRSF cGMP-dep_kinase UniProtKB/TrEMBL
PRINTS CGMPKINASE UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniGene Ssc.87636 ENTREZGENE
UniProt A0A4X1V6L9_PIG UniProtKB/TrEMBL
  A0A4X1V908_PIG UniProtKB/TrEMBL
  A0MLS8_PIG UniProtKB/TrEMBL
  Q3YJM5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1SD02 UniProtKB/TrEMBL
VGNC ID VGNC:91816 ENTREZGENE