Cyp26b1 (cytochrome P450, 26, retinoic acid B1) - Rat Genome Database

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Gene: Cyp26b1 (cytochrome P450, 26, retinoic acid B1) Mus musculus
Analyze
Symbol: Cyp26b1
Name: cytochrome P450, 26, retinoic acid B1 (Ensembl:cytochrome P450, family 26, subfamily b, polypeptide 1)
RGD ID: 1332006
MGI Page MGI
Description: Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; and retinoic acid binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of tongue muscle cell differentiation; and tongue morphogenesis. Acts upstream of or within several processes, including cornification; establishment of T cell polarity; and establishment of skin barrier. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart and pericardium; and sensory organ. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: CP2; CP26; cytochrome P450 26B1; cytochrome P450 retinoic acid-inactivating 2; cytochrome P450, family 26, subfamily b, polypeptide 1; cytochrome P450RAI-2; P450R; P450RAI-2; retinoic acid B1; retinoic acid hydroxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39684,548,396 - 84,570,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl684,548,396 - 84,570,890 (-)EnsemblGRCm39 Ensembl
GRCm38684,571,414 - 84,593,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl684,571,414 - 84,593,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37684,521,408 - 84,543,902 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36684,537,602 - 84,559,404 (-)NCBIMGSCv36mm8
Celera686,552,442 - 86,574,953 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map636.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
ammonium chloride  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroprene  (ISO)
choline  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP)
cyproconazole  (EXP)
D-glucose  (EXP)
deguelin  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
fipronil  (ISO)
fluconazole  (EXP)
fluoxetine  (ISO)
flusilazole  (ISO)
folic acid  (EXP)
fructose  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glucose  (EXP)
hexaconazole  (EXP)
hexadecanoic acid  (ISO)
ibuprofen  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
nitrofen  (ISO)
oleic acid  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
picoxystrobin  (ISO)
quercitrin  (ISO)
quinalphos  (EXP)
quinolines  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vinyl carbamate  (EXP)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic valve cusp morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal corneocyte envelope morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal lymphatic vessel endothelial cell morphology  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal male germ cell apoptosis  (IAGP)
abnormal male meiosis  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal vitamin A metabolism  (IAGP)
absent keratohyalin granules  (IAGP)
decreased male germ cell number  (IAGP)
delayed chondrocyte differentiation  (IAGP)
enlarged aortic valve  (IAGP)
eyelids open at birth  (IAGP)
heart valve hyperplasia  (IAGP)
hemorrhage  (IAGP)
impaired skin barrier function  (IAGP)
increased Leydig cell number  (IAGP)
micrognathia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oligodactyly  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
respiratory distress  (IAGP)
short forelimb  (IAGP)
short hindlimb  (IAGP)
skin edema  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
thick aortic valve cusps  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
11. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
12. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
Additional References at PubMed
PMID:8889548   PMID:11744378  


Genomics

Comparative Map Data
Cyp26b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39684,548,396 - 84,570,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl684,548,396 - 84,570,890 (-)EnsemblGRCm39 Ensembl
GRCm38684,571,414 - 84,593,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl684,571,414 - 84,593,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37684,521,408 - 84,543,902 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36684,537,602 - 84,559,404 (-)NCBIMGSCv36mm8
Celera686,552,442 - 86,574,953 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map636.45NCBI
CYP26B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38272,129,238 - 72,147,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl272,129,238 - 72,147,862 (-)EnsemblGRCh38hg38GRCh38
GRCh37272,356,367 - 72,374,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36272,209,875 - 72,228,471 (-)NCBINCBI36Build 36hg18NCBI36
Build 34272,268,021 - 72,286,618NCBI
Celera272,206,377 - 72,224,974 (-)NCBICelera
Cytogenetic Map2p13.2NCBI
HuRef272,092,551 - 72,111,176 (-)NCBIHuRef
CHM1_1272,285,791 - 72,304,416 (-)NCBICHM1_1
T2T-CHM13v2.0272,142,327 - 72,160,951 (-)NCBIT2T-CHM13v2.0
Cyp26b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84118,599,356 - 118,616,176 (-)NCBIGRCr8
mRatBN7.24117,041,808 - 117,058,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,041,808 - 117,058,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4122,523,010 - 122,539,827 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04118,298,178 - 118,314,997 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04116,911,101 - 116,927,919 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04116,261,796 - 116,278,615 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,261,796 - 116,278,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04180,848,037 - 180,865,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44118,734,786 - 118,751,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14118,979,266 - 118,996,087 (-)NCBI
Celera4106,028,365 - 106,045,185 (-)NCBICelera
Cytogenetic Map4q34NCBI
LOC102023166
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542413,336,189 - 13,355,423 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542413,336,189 - 13,355,368 (+)NCBIChiLan1.0ChiLan1.0
CYP26B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21254,241,428 - 54,260,740 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A54,244,188 - 54,263,488 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A72,172,658 - 72,191,410 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A73,667,847 - 73,686,433 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A73,670,830 - 73,686,433 (-)Ensemblpanpan1.1panPan2
CYP26B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11750,633,397 - 50,653,882 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1750,633,413 - 50,653,894 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1750,280,509 - 50,301,422 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01751,501,857 - 51,522,773 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1751,503,195 - 51,522,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11750,510,776 - 50,531,647 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01750,576,538 - 50,597,422 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01751,150,622 - 51,171,524 (+)NCBIUU_Cfam_GSD_1.0
LOC101975674
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629212,541,815 - 12,561,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649116,010,070 - 16,028,895 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649116,010,394 - 16,028,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP26B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl370,572,197 - 70,593,408 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1370,573,551 - 70,593,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2373,914,357 - 73,934,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP26B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11435,030,011 - 35,057,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1435,038,654 - 35,057,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604577,009,329 - 77,029,165 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714280
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247621,456,440 - 1,472,381 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247621,455,828 - 1,474,201 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp26b1
614 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2156
Count of miRNA genes:589
Interacting mature miRNAs:693
Transcripts:ENSMUST00000077705, ENSMUST00000168003
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse

Markers in Region
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37684,522,596 - 84,522,740UniSTSGRCm37
MGSCv37684,534,260 - 84,534,375UniSTSGRCm37
Celera686,553,630 - 86,553,774UniSTS
Celera686,565,295 - 86,565,410UniSTS
Cytogenetic Map6C3UniSTS
cM Map6 UniSTS
cM MapUN UniSTS
BF398420  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38684,572,546 - 84,572,746UniSTSGRCm38
MGSCv37684,522,540 - 84,522,740UniSTSGRCm37
Celera686,553,574 - 86,553,774UniSTS
Cytogenetic Map6C3UniSTS
D4Got92  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38684,586,584 - 84,586,722UniSTSGRCm38
MGSCv37684,536,578 - 84,536,716UniSTSGRCm37
Celera686,567,617 - 86,567,755UniSTS
Cytogenetic Map6C3UniSTS
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38684,584,266 - 84,584,381UniSTSGRCm38
MGSCv37684,534,260 - 84,534,375UniSTSGRCm37
Celera686,565,295 - 86,565,410UniSTS
Cytogenetic Map6C3UniSTS
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38684,572,602 - 84,572,746UniSTSGRCm38
MGSCv37684,522,596 - 84,522,740UniSTSGRCm37
Celera686,553,630 - 86,553,774UniSTS
Cytogenetic Map6C3UniSTS
cM MapUN UniSTS
cM Map6 UniSTS
Cyp26b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000077705   ⟹   ENSMUSP00000076886
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl684,548,926 - 84,570,728 (-)Ensembl
GRCm38.p6 Ensembl684,571,944 - 84,593,746 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168003   ⟹   ENSMUSP00000128391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl684,548,926 - 84,570,890 (-)Ensembl
GRCm38.p6 Ensembl684,571,944 - 84,593,908 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204109   ⟹   ENSMUSP00000144998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl684,551,223 - 84,564,987 (-)Ensembl
GRCm38.p6 Ensembl684,574,241 - 84,588,005 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204146   ⟹   ENSMUSP00000145092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl684,548,926 - 84,565,620 (-)Ensembl
GRCm38.p6 Ensembl684,571,944 - 84,588,638 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205228   ⟹   ENSMUSP00000144836
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl684,548,396 - 84,564,662 (-)Ensembl
GRCm38.p6 Ensembl684,571,414 - 84,587,680 (-)Ensembl
RefSeq Acc Id: NM_001177713   ⟹   NP_001171184
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39684,548,396 - 84,570,890 (-)NCBI
GRCm38684,571,414 - 84,593,908 (-)ENTREZGENE
MGSCv37684,521,408 - 84,543,902 (-)RGD
Celera686,552,442 - 86,574,953 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_175475   ⟹   NP_780684
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39684,548,396 - 84,570,792 (-)NCBI
GRCm38684,571,414 - 84,593,810 (-)NCBI
MGSCv37684,521,408 - 84,543,902 (-)RGD
Celera686,552,442 - 86,574,953 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505972   ⟹   XP_006506035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39684,548,405 - 84,563,890 (-)NCBI
GRCm38684,571,423 - 84,586,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241300   ⟹   XP_011239602
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39684,548,405 - 84,564,693 (-)NCBI
GRCm38684,571,423 - 84,587,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255338   ⟹   XP_030111198
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39684,548,405 - 84,569,807 (-)NCBI
GRCm38684,571,423 - 84,592,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036166047   ⟹   XP_036021940
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39684,548,405 - 84,569,807 (-)NCBI
Sequence:
Protein Sequences
Ensembl Protein ENSMUSP00000076886.4
  ENSMUSP00000128391.3
  ENSMUSP00000144836.2
  ENSMUSP00000144998.2
  ENSMUSP00000145092.2
RefSeq Acc Id: NP_780684   ⟸   NM_175475
- Sequence:
RefSeq Acc Id: NP_001171184   ⟸   NM_001177713
- Sequence:
RefSeq Acc Id: XP_006506035   ⟸   XM_006505972
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011239602   ⟸   XM_011241300
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030111198   ⟸   XM_030255338
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000144998   ⟸   ENSMUST00000204109
Ensembl Acc Id: ENSMUSP00000145092   ⟸   ENSMUST00000204146
Ensembl Acc Id: ENSMUSP00000144836   ⟸   ENSMUST00000205228
Ensembl Acc Id: ENSMUSP00000128391   ⟸   ENSMUST00000168003
Ensembl Acc Id: ENSMUSP00000076886   ⟸   ENSMUST00000077705
RefSeq Acc Id: XP_036021940   ⟸   XM_036166047
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811W2-F1-model_v2 AlphaFold Q811W2 1-512 view protein structure

Promoters
RGD ID:6890202
Promoter ID:EPDNEW_M8552
Type:initiation region
Name:Cyp26b1_1
Description:Mus musculus cytochrome P450, family 26, subfamily b, polypeptide1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8553  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38684,588,638 - 84,588,698EPDNEW
RGD ID:6890204
Promoter ID:EPDNEW_M8553
Type:multiple initiation site
Name:Cyp26b1_2
Description:Mus musculus cytochrome P450, family 26, subfamily b, polypeptide1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8552  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38684,588,972 - 84,589,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2176159 AgrOrtholog
Ensembl Genes ENSMUSG00000063415 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000077705.6 UniProtKB/Swiss-Prot
  ENSMUST00000168003.9 UniProtKB/Swiss-Prot
  ENSMUST00000204109.2 UniProtKB/TrEMBL
  ENSMUST00000204146.3 UniProtKB/Swiss-Prot
  ENSMUST00000205228.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232174 UniProtKB/Swiss-Prot
MGD MGI:2176159 ENTREZGENE
NCBI Gene Cyp26b1 ENTREZGENE
PANTHER CYTOCHROME P450 26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 26B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp26b1 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SUV4_MOUSE UniProtKB/TrEMBL
  A0A0N4SV88_MOUSE UniProtKB/TrEMBL
  CP26B_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TM12 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Cyp26b1  cytochrome P450, 26, retinoic acid B1  Cyp26b1  cytochrome P450, family 26, subfamily b, polypeptide 1  Symbol and/or name change 5135510 APPROVED