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Gene: Dio2 (deiodinase, iodothyronine, type II) Mus musculus
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Symbol: Dio2
Name: deiodinase, iodothyronine, type II
Description: Exhibits thyroxine 5'-deiodinase activity. Involved in brown fat cell differentiation; positive regulation of cold-induced thermogenesis; and thyroid hormone catabolic process. Predicted to localize to integral component of membrane. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; AI324267; DIOII; iodothyronine type II deiodinase; type 2 DI; type II iodothyronine deiodinase; type-II 5' deiodinase; type-II 5'-deiodinase
Orthologs:
Homo sapiens (human) : DIO2 (iodothyronine deiodinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dio2 (iodothyronine deiodinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio2 (iodothyronine deiodinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO2 (iodothyronine deiodinase 2)
Canis lupus familiaris (dog) : DIO2 (iodothyronine deiodinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio2 (iodothyronine deiodinase 2)
Sus scrofa (pig) : DIO2 (iodothyronine deiodinase 2)
Chlorocebus sabaeus (African green monkey) : DIO2 (iodothyronine deiodinase 2)
Heterocephalus glaber (naked mole-rat) : Dio2 (iodothyronine deiodinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)EnsemblGRCm38mm10GRCm38
GRCm381290,724,552 - 90,739,038 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371291,962,992 - 91,976,878 (-)NCBIGRCm37mm9NCBIm37
MGSCv361291,129,943 - 91,143,828 (-)NCBImm8
Celera1292,060,514 - 92,074,181 (-)NCBICelera
Cytogenetic Map12D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dio2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68620
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.