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Gene: Dio2 (deiodinase, iodothyronine, type II) Mus musculus
Symbol: Dio2
Name: deiodinase, iodothyronine, type II
Description: Exhibits thyroxine 5'-deiodinase activity. Involved in brown fat cell differentiation; positive regulation of cold-induced thermogenesis; and thyroid hormone catabolic process. Predicted to localize to integral component of membrane. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; AI324267; DIOII; iodothyronine type II deiodinase; type 2 DI; type II iodothyronine deiodinase; type-II 5' deiodinase; type-II 5'-deiodinase
Homo sapiens (human) : DIO2 (iodothyronine deiodinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dio2 (iodothyronine deiodinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio2 (iodothyronine deiodinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO2 (iodothyronine deiodinase 2)
Canis lupus familiaris (dog) : DIO2 (iodothyronine deiodinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio2 (iodothyronine deiodinase 2)
Sus scrofa (pig) : DIO2 (iodothyronine deiodinase 2)
Chlorocebus sabaeus (African green monkey) : DIO2 (iodothyronine deiodinase 2)
Heterocephalus glaber (naked mole-rat) : Dio2 (iodothyronine deiodinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)EnsemblGRCm38mm10GRCm38
GRCm381290,724,552 - 90,739,038 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371291,962,992 - 91,976,878 (-)NCBIGRCm37mm9NCBIm37
MGSCv361291,129,943 - 91,143,828 (-)NCBImm8
Celera1292,060,514 - 92,074,181 (-)NCBICelera
Cytogenetic Map12D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dio2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68620
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.