Dio2 (deiodinase, iodothyronine, type II) - Rat Genome Database

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Gene: Dio2 (deiodinase, iodothyronine, type II) Mus musculus
Analyze
Symbol: Dio2
Name: deiodinase, iodothyronine, type II
RGD ID: 68620
MGI Page MGI
Description: Enables thyroxine 5'-deiodinase activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation; cellular lipid metabolic process; and thyroid hormone catabolic process. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brown fat; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human DIO2 (iodothyronine deiodinase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5DII; AI324267; DIOII; iodothyronine type II deiodinase; type 2 DI; type II iodothyronine deiodinase; type-II 5' deiodinase; type-II 5'-deiodinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391290,691,326 - 90,705,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1290,691,326 - 90,705,812 (-)EnsemblGRCm39 Ensembl
GRCm381290,724,552 - 90,739,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371291,962,992 - 91,976,878 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361291,129,943 - 91,143,828 (-)NCBIMGSCv36mm8
Celera1292,060,514 - 92,074,181 (-)NCBICelera
Cytogenetic Map12D3NCBI
cM Map1244.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(E,E)-hydramethylnon  (ISO)
(S)-amphetamine  (EXP)
1,2,4-trimethylbenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrophenol  (EXP)
2-Ethylhexyl acrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
Aurothioglucose  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boron nitride  (ISO)
bucladesine  (ISO)
butein  (ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
captafol  (ISO)
carbon nanotube  (EXP,ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dibenziodolium  (ISO)
Didecyldimethylammonium  (ISO)
diethyl hydrogen phosphate  (ISO)
diethylstilbestrol  (ISO)
Dimethyl succinate  (ISO)
dinocap  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
ethanol  (EXP)
Ethylenethiourea  (EXP)
fipronil  (ISO)
fisetin  (ISO)
fluazinam  (ISO)
formaldehyde  (ISO)
Geniposide  (EXP)
genistein  (ISO)
glyphosate  (EXP,ISO)
GW 7647  (ISO)
harmine  (EXP)
hexachlorobenzene  (ISO)
hydramethylnon  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iodomethane  (ISO)
Iopanoic acid  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
Licarin A  (EXP)
Licochalcone B  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
masoprocol  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (EXP)
mercaptopurine  (ISO)
methamphetamine  (ISO)
methyltrioctylammonium chloride  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
nickel sulfate  (ISO)
octhilinone  (ISO)
p-tert-Amylphenol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thyroxine  (EXP,ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
tricetin  (ISO)
triflumizole  (ISO)
troglitazone  (EXP,ISO)
undecane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
xanthohumol  (ISO)
zoledronic acid  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome. Fiorito M, etal., Obesity (Silver Spring). 2007 Dec;15(12):2889-95.
2. Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects. Grarup N, etal., J Clin Endocrinol Metab. 2007 Jan;92(1):363-6. Epub 2006 Oct 31.
3. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Gumieniak O, etal., Hypertension. 2007 Mar;49(3):461-6. Epub 2007 Jan 15.
4. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Mentuccia D, etal., Diabetes. 2002 Mar;51(3):880-3.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9927339   PMID:10349636   PMID:10403186   PMID:10655523   PMID:10715551   PMID:10940497   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11696583   PMID:11731615  
PMID:12477932   PMID:12582014   PMID:12586753   PMID:14681479   PMID:14988240   PMID:14993610   PMID:15226823   PMID:15471965   PMID:15831471   PMID:16141072   PMID:16141073   PMID:17110533  
PMID:17138654   PMID:17189204   PMID:17332058   PMID:18682303   PMID:19095741   PMID:19196796   PMID:19656972   PMID:20211971   PMID:20368437   PMID:20453157   PMID:20660060   PMID:20881246  
PMID:20926587   PMID:20978344   PMID:21237159   PMID:21285310   PMID:21335378   PMID:21628384   PMID:21652727   PMID:21677750   PMID:21685153   PMID:21698184   PMID:21771965   PMID:21873635  
PMID:21878515   PMID:22065740   PMID:22479358   PMID:22523155   PMID:23499423   PMID:23524969   PMID:24098341   PMID:24154525   PMID:24265449   PMID:24386638   PMID:24487027   PMID:24601886  
PMID:24635350   PMID:24635351   PMID:24703692   PMID:24731098   PMID:24797630   PMID:24949664   PMID:25083788   PMID:25456070   PMID:25505333   PMID:25543145   PMID:25549200   PMID:25550340  
PMID:25555216   PMID:26214036   PMID:26508642   PMID:26727108   PMID:27163789   PMID:27185876   PMID:27302464   PMID:27501182   PMID:27777310   PMID:27777311   PMID:27967605   PMID:28088877  
PMID:28324012   PMID:28324063   PMID:28364022   PMID:28407057   PMID:28570265   PMID:28630021   PMID:28637283   PMID:28743746   PMID:28763438   PMID:29045837   PMID:29320745   PMID:29648626  
PMID:29688375   PMID:29728617   PMID:29874126   PMID:29905787   PMID:30352046   PMID:30352954   PMID:30908637   PMID:30951174   PMID:31215118   PMID:31359845   PMID:31433978   PMID:31693883  
PMID:31776338   PMID:32439985   PMID:32776612   PMID:32787533   PMID:33307956   PMID:33473114   PMID:33732701   PMID:33888560   PMID:34248495   PMID:34436572   PMID:35238380   PMID:35733999  
PMID:35760530   PMID:35863637   PMID:36680751   PMID:36841836   PMID:37353518   PMID:38038617   PMID:38836615   PMID:38879014   PMID:38901782   PMID:39107332  


Genomics

Comparative Map Data
Dio2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391290,691,326 - 90,705,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1290,691,326 - 90,705,812 (-)EnsemblGRCm39 Ensembl
GRCm381290,724,552 - 90,739,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371291,962,992 - 91,976,878 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361291,129,943 - 91,143,828 (-)NCBIMGSCv36mm8
Celera1292,060,514 - 92,074,181 (-)NCBICelera
Cytogenetic Map12D3NCBI
cM Map1244.05NCBI
DIO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381480,197,526 - 80,231,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1480,197,526 - 80,387,757 (-)EnsemblGRCh38hg38GRCh38
GRCh371480,663,869 - 80,697,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361479,733,622 - 79,748,278 (-)NCBINCBI36Build 36hg18NCBI36
Build 341479,733,622 - 79,748,276NCBI
Celera1460,701,940 - 60,716,595 (-)NCBICelera
Cytogenetic Map14q31.1NCBI
HuRef1460,829,594 - 60,863,130 (-)NCBIHuRef
CHM1_11480,604,355 - 80,637,840 (-)NCBICHM1_1
T2T-CHM13v2.01474,407,785 - 74,441,322 (-)NCBIT2T-CHM13v2.0
Dio2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86115,396,308 - 115,410,594 (-)NCBIGRCr8
mRatBN7.26109,665,523 - 109,679,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6109,665,523 - 109,679,809 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6109,817,319 - 109,831,629 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06110,116,102 - 110,130,412 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06109,485,837 - 109,500,136 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06114,475,156 - 114,489,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6114,476,142 - 114,476,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06123,743,030 - 123,752,835 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46114,307,758 - 114,317,563 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6107,438,850 - 107,453,155 (-)NCBICelera
RH 3.4 Map6755.1RGD
Cytogenetic Map6q31NCBI
Dio2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554383,950,983 - 3,960,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554383,946,830 - 3,961,049 (-)NCBIChiLan1.0ChiLan1.0
DIO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21581,289,683 - 81,308,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11480,506,186 - 80,527,254 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01460,756,781 - 60,775,255 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11479,956,305 - 79,970,938 (-)NCBIpanpan1.1PanPan1.1panPan2
DIO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1852,686,211 - 52,695,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl852,686,211 - 52,695,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha852,244,364 - 52,253,381 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0852,915,654 - 52,924,683 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl852,910,578 - 53,101,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1852,604,180 - 52,613,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0852,606,880 - 52,615,892 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0852,999,420 - 53,008,436 (-)NCBIUU_Cfam_GSD_1.0
Dio2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864023,285,838 - 23,299,412 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364888,769,555 - 8,783,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7103,096,433 - 103,323,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17103,096,414 - 103,110,749 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27109,299,323 - 109,308,576 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12457,521,806 - 57,536,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605345,260,845 - 45,447,678 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dio2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473421,787,705 - 21,802,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dio2
413 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1474
Count of miRNA genes:713
Interacting mature miRNAs:896
Transcripts:ENSMUST00000082432
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
AI324267  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381290,724,740 - 90,724,843UniSTSGRCm38
MGSCv371291,963,180 - 91,963,283UniSTSGRCm37
Celera1292,060,702 - 92,060,805UniSTS
Cytogenetic Map12D3UniSTS
Whitehead/MRC_RH12838.19UniSTS
Dio2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381290,724,890 - 90,725,629UniSTSGRCm38
MGSCv371291,963,330 - 91,964,069UniSTSGRCm37
Celera1292,060,852 - 92,061,593UniSTS
Cytogenetic Map12D3UniSTS
cM Map12 UniSTS
RH138032  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381290,729,438 - 90,729,578UniSTSGRCm38
MGSCv371291,967,878 - 91,968,018UniSTSGRCm37
Celera1292,065,402 - 92,065,542UniSTS
Cytogenetic Map12D3UniSTS
D6Wox25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381290,738,505 - 90,738,658UniSTSGRCm38
MGSCv371291,976,945 - 91,977,098UniSTSGRCm37
Cytogenetic Map12D3UniSTS
Dio2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12D3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF093137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF096875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE655410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ033571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY328738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01118771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB522312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ055557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO042302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO425270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO427407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT573100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV555526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX223140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000082432   ⟹   ENSMUSP00000081013
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1290,691,326 - 90,705,812 (-)Ensembl
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)Ensembl
RefSeq Acc Id: NM_010050   ⟹   NP_034180
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391290,691,326 - 90,705,812 (-)NCBI
GRCm381290,724,552 - 90,739,038 (-)NCBI
MGSCv371291,962,992 - 91,976,878 (-)RGD
Celera1292,060,514 - 92,074,181 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034180   ⟸   NM_010050
- UniProtKB: A0A8Z1S5Q0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000081013   ⟸   ENSMUST00000082432
Protein Domains
Thioredoxin

Promoters
RGD ID:8678926
Promoter ID:EPDNEW_M17493
Type:single initiation site
Name:Dio2_1
Description:Mus musculus deiodinase, iodothyronine, type II , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381290,739,038 - 90,739,098EPDNEW
RGD ID:6822846
Promoter ID:MM_KWN:12340
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_010050
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361291,977,081 - 91,977,581 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338833 AgrOrtholog
Ensembl Genes ENSMUSG00000007682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000082432 ENTREZGENE
  ENSMUST00000082432.7 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Iodothyronine_deiodinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iodothyronine_deiodinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/TrEMBL
KEGG Report mmu:13371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1338833 ENTREZGENE
NCBI Gene 13371 ENTREZGENE
PANTHER PTHR11781 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYPE II IODOTHYRONINE DEIODINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T4_deiodinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dio2 PhenoGen
PIRSF IOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE T4_DEIODINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8Z1S5Q0 ENTREZGENE, UniProtKB/TrEMBL
  IOD2_MOUSE UniProtKB/Swiss-Prot
  Q9QXV5_MOUSE UniProtKB/TrEMBL
  Q9Z1Y9 ENTREZGENE
UniProt Secondary Q05A70 UniProtKB/Swiss-Prot
  Q9JHH1 UniProtKB/Swiss-Prot