(+)-pilocarpine - Ontology Report - Rat Genome Database

(+)-pilocarpine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	(+)-pilocarpine	go back to main search page
Accession:	CHEBI:8207	browse the term
Definition:	The (+)-enantiomer of pilocarpine.
Synonyms:	exact_synonym:	(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
	related_synonym:	(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone; Formula=C11H16N2O2; InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1; InChIKey=QCHFTSOMWOSFHM-WPRPVWTQSA-N; SMILES=CC[C@H]1[C@H](COC1=O)Cc1cncn1C
	xref:	CAS:92-13-7; Drug_Central:2166; HMDB:HMDB0015217; KEGG:C07474; KEGG:D00525; KNApSAcK:C00002355; LINCS:LSM-5909
	xref_mesh:	MESH:D010862
	xref:	PMID:24595384; Reaxys:86187; Wikipedia:Pilocarpine
	cyclic_relationship:	is_enantiomer_of CHEBI:39464

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Genes (302)

(+)-pilocarpine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Pilocarpine results in increased expression of A2M mRNA

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

affects expression
increases expression

Pilocarpine affects the expression of ABCB1A mRNA
Pilocarpine results in increased expression of ABCB1A mRNA; Pilocarpine results in increased expression of ABCB1A protein

PMID:14706787 PMID:17437408 PMID:19055492

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects expression
increases expression

Pilocarpine affects the expression of ABCB1B mRNA
Pilocarpine results in increased expression of ABCB1B mRNA; Pilocarpine results in increased expression of ABCB1B protein

PMID:14706787 PMID:19055492 PMID:19570321

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

affects expression

Pilocarpine affects the expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression

Pilocarpine results in increased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 5

affects expression

Pilocarpine affects the expression of ABCC5 mRNA

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:80,473,872...80,567,253

G

angiotensin I converting enzyme

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE protein]

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

decreases activity
decreases expression
increases expression
multiple interactions

Pilocarpine results in decreased activity of ACHE protein
Pilocarpine results in decreased expression of ACHE protein
Pilocarpine results in increased expression of ACHE mRNA alternative form; Pilocarpine results in increased expression of ACHE protein alternative form
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]; [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
garcinielliptone FC inhibits the reaction [Pilocarpine results in decreased activity of ACHE protein]

PMID:16481111 PMID:18242586 PMID:18333967 PMID:19669875 PMID:19932735 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651

G

actin, beta

multiple interactions

Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877

G

adenosine A1 receptor

multiple interactions

[2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

affects response to substance

ADORA2A protein affects the susceptibility to Pilocarpine

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 1B

increases response to substance

ADRA1B protein results in increased susceptibility to Pilocarpine

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919

G

agrin

increases expression

Pilocarpine results in increased expression of AGRN protein

NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:166,749,310...166,786,003

G

angiotensin II receptor, type 1a

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A protein]

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

multiple interactions

[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of AGTR2 mRNA

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057

G

allograft inflammatory factor 1

increases expression

Pilocarpine results in increased expression of AIF1 protein

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668

G

A-kinase anchoring protein 5

increases response to substance

AKAP5 protein mutant form results in increased susceptibility to Pilocarpine

NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:95,051,537...95,061,578

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

Pilocarpine results in decreased phosphorylation of AKT1 protein
1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Pilocarpine results in decreased phosphorylation of AKT1 protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased phosphorylation of AKT1 protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Pilocarpine results in decreased phosphorylation of AKT1 protein]]

PMID:19429016 PMID:30542433 PMID:31018114

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

decreases expression
multiple interactions
decreases activity

Pilocarpine results in decreased expression of ALAD protein
Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]; Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]
carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]

PMID:19798568 PMID:20026167 PMID:20584200 PMID:25490531

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474

G

ankyrin 3

increases expression

Pilocarpine results in increased expression of ANK3 mRNA; Pilocarpine results in increased expression of ANK3 protein

NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,602,786...19,086,300

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression
decreases expression
affects localization

Pilocarpine results in increased expression of APEX1 mRNA
Pilocarpine results in decreased expression of APEX1 protein
Pilocarpine affects the localization of APEX1 mRNA

PMID:17971868 PMID:20206232 PMID:20446108

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

amyloid beta precursor like protein 1

decreases expression

Pilocarpine results in decreased expression of APLP1 mRNA

NCBI chr 1:94,824,330...94,834,705
Ensembl chr 1:85,696,882...85,707,155

G

aquaporin 4

decreases expression

Pilocarpine results in decreased expression of AQP4 protein

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 5

multiple interactions
affects localization

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:130,721,748...130,726,209

G

acid sensing ion channel subunit 1

decreases expression

Pilocarpine results in decreased expression of ASIC1 mRNA

NCBI chr 7:132,677,158...132,707,379
Ensembl chr 7:130,799,917...130,828,541

G

acid sensing ion channel subunit 2

decreases expression

Pilocarpine results in decreased expression of ASIC2 mRNA alternative form

NCBI chr10:66,368,308...67,438,237
Ensembl chr10:65,870,594...66,940,424

G

activating transcription factor 2

multiple interactions
increases expression

[Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein
Pilocarpine results in increased expression of ATF2 mRNA

PMID:17971868 PMID:19430551

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

Pilocarpine results in increased expression of ATP2A2 protein

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101

G

ATRX, chromatin remodeler

increases expression

Pilocarpine results in increased expression of ATRX mRNA

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:70,850,981...70,997,330

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

Pilocarpine results in decreased expression of BAX mRNA
Pilocarpine results in increased expression of BAX mRNA; Pilocarpine results in increased expression of BAX protein

PMID:14754538 PMID:17971868 PMID:19429016

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

[Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148

G

BCL10, immune signaling adaptor

decreases expression
increases expression

Pilocarpine results in decreased expression of BCL10 mRNA
Pilocarpine results in increased expression of BCL10 mRNA

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

decreases expression

Pilocarpine results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

Pilocarpine results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998

G

bradykinin receptor B1

decreases response to substance

BDKRB1 protein mutant form results in decreased susceptibility to Pilocarpine

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

increases response to substance

BDKRB2 protein mutant form results in increased susceptibility to Pilocarpine

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

increases expression
multiple interactions
decreases expression

Pilocarpine results in increased expression of BDNF protein modified form
1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 1 alpha,24-dihydroxyvitamin D3 promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA alternative form]; [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA; Pilocarpine results in increased expression of and results in increased localization of BDNF protein; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Pilocarpine results in decreased expression of BDNF protein
Pilocarpine results in increased expression of BDNF exon; Pilocarpine results in increased expression of BDNF mRNA; Pilocarpine results in increased expression of BDNF mRNA alternative form; Pilocarpine results in increased expression of BDNF protein

PMID:8405262 PMID:8635431 PMID:8821376 PMID:9015327 PMID:9073163 More...

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions
increases expression

Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]; Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]
Pilocarpine results in increased expression of BECN1 mRNA; Pilocarpine results in increased expression of BECN1 protein

PMID:17971868 PMID:19138675

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

bone morphogenetic protein 4

decreases expression
increases expression

Pilocarpine results in decreased expression of BMP4 mRNA
Pilocarpine results in increased expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306

G

BCL2 interacting protein 1

increases expression

Pilocarpine results in increased expression of BNIP1 mRNA

NCBI chr10:16,891,317...16,903,561
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 3

increases expression

Pilocarpine results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359

G

calcium voltage-gated channel subunit alpha1 A

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1A protein
Pilocarpine results in increased expression of CACNA1A protein

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 B

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1B mRNA; Pilocarpine results in decreased expression of CACNA1B protein
Pilocarpine results in increased expression of CACNA1B protein

NCBI chr 3:27,779,133...27,944,292
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel subunit alpha1 C

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1C protein
Pilocarpine results in increased expression of CACNA1C protein

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648

G

calcium voltage-gated channel subunit alpha1 D

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1D protein
Pilocarpine results in increased expression of CACNA1D protein

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215

G

caspase 12

multiple interactions

[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein]

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
Pilocarpine results in increased cleavage of CASP3 protein
Pilocarpine results in increased expression of CASP3 protein modified form
ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
[Pilocarpine co-treated with Lithium] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Pilocarpine results in increased cleavage of and results in increased activity of CASP3 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]

PMID:12097334 PMID:18708038 PMID:18815271 PMID:19429016 PMID:19631748 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

multiple interactions

Pilocarpine results in increased cleavage of and results in increased activity of CASP6 protein

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502

G

caspase 9

increases expression

Pilocarpine results in increased expression of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
multiple interactions
increases expression

Pilocarpine results in increased activity of CAT protein
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]; Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]

PMID:15245787 PMID:15752349 PMID:16115668 PMID:17205390 PMID:17383094 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression
decreases expression

Pilocarpine results in increased expression of CCL2 mRNA; Pilocarpine results in increased expression of CCL2 protein
Pilocarpine results in decreased expression of CCL2 protein

PMID:15193289 PMID:17971868 PMID:19490431 PMID:20034406

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

decreases expression
increases expression

Pilocarpine results in decreased expression of CCL3 protein
Pilocarpine results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine receptor 10

decreases expression

Pilocarpine results in decreased expression of CCR10 mRNA; Pilocarpine results in decreased expression of CCR10 protein

NCBI chr10:86,608,836...86,611,273
Ensembl chr10:86,108,551...86,110,988

G

C-C motif chemokine receptor 2

increases expression
decreases expression

Pilocarpine results in increased expression of CCR2 protein
Pilocarpine results in decreased expression of CCR2 mRNA; Pilocarpine results in decreased expression of CCR2 protein

PMID:19490431 PMID:20034406

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 3

decreases expression

Pilocarpine results in decreased expression of CCR3 mRNA; Pilocarpine results in decreased expression of CCR3 protein

NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 7

decreases expression

Pilocarpine results in decreased expression of CCR7 mRNA; Pilocarpine results in decreased expression of CCR7 protein

NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor 8

decreases expression

Pilocarpine results in decreased expression of CCR8 mRNA; Pilocarpine results in decreased expression of CCR8 protein

NCBI chr 8:128,703,966...128,705,926
Ensembl chr 8:119,826,568...119,827,629

G

C-C motif chemokine receptor 9

decreases expression

Pilocarpine results in decreased expression of CCR9 mRNA; Pilocarpine results in decreased expression of CCR9 protein

NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:123,395,813...123,413,969

G

CD40 molecule

increases expression
multiple interactions

Pilocarpine results in increased expression of CD40 protein
rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

increases expression

Pilocarpine results in increased expression of CD44 protein

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

cadherin 1

decreases expression
increases expression

Pilocarpine results in decreased expression of CDH1 protein
Pilocarpine results in increased expression of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

increases expression

Pilocarpine results in increased expression of CDH2 mRNA; Pilocarpine results in increased expression of CDH2 protein

PMID:12125071 PMID:12387456

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

increases expression

Pilocarpine results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

increases expression

Pilocarpine results in increased expression of CDK2 mRNA

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1B

increases expression

Pilocarpine results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

decreases expression
increases expression

Pilocarpine results in decreased expression of CDKN2A mRNA
Pilocarpine results in increased expression of CDKN2A mRNA

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein alpha

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of CEBPA mRNA]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

choline O-acetyltransferase

decreases activity
decreases expression
multiple interactions

Pilocarpine results in decreased activity of CHAT protein
Pilocarpine results in decreased expression of CHAT protein
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein

PMID:19669875 PMID:19932735 PMID:19941057

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093

G

cholinergic receptor, muscarinic 1

multiple interactions
increases activity
affects response to substance
decreases expression
affects binding
increases expression

[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]
CHRM1 protein affects the susceptibility to Pilocarpine
CHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]
Pilocarpine results in decreased expression of CHRM1 protein
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
CHRM1 protein binds to Pilocarpine
Pilocarpine results in increased expression of CHRM1 protein

PMID:9224827 PMID:11527950 PMID:12713643 PMID:14559291 PMID:15967574 More...

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

decreases expression
multiple interactions
affects binding
increases expression

Pilocarpine results in decreased expression of CHRM2 protein
Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CHRM2 protein binds to Pilocarpine
eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]
Pilocarpine results in increased expression of CHRM2 protein

PMID:9224827 PMID:14559291 PMID:32234387

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions
affects binding
increases expression

brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
CHRM3 protein binds to Pilocarpine
Pilocarpine results in increased expression of CHRM3 protein

PMID:9224827 PMID:32234387

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions
affects binding
increases expression

Pilocarpine binds to and results in increased activity of CHRM4 protein
brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; eburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]
CHRM4 protein binds to Pilocarpine
Pilocarpine results in increased expression of CHRM4 protein

PMID:9224827 PMID:9920179 PMID:32234387

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

increases expression

Pilocarpine results in increased expression of CHRM5 protein

NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:99,284,846...99,337,252

G

calcium and integrin binding 1

increases expression

Pilocarpine results in increased expression of CIB1 mRNA

NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:134,178,331...134,213,423

G

chloride voltage-gated channel 2

affects expression

Pilocarpine affects the expression of CLCN2 protein

NCBI chr11:93,702,382...93,716,059
Ensembl chr11:80,198,153...80,211,657

G

calponin 3

increases expression

Pilocarpine results in increased expression of CNN3 protein

NCBI chr 2:212,203,661...212,234,772
Ensembl chr 2:209,518,948...209,550,104

G

cannabinoid receptor 1

decreases expression

Pilocarpine results in decreased expression of CNR1 protein

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099

G

ciliary neurotrophic factor

increases expression

Pilocarpine results in increased expression of CNTF mRNA

NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:209,887,854...209,889,877

G

colony stimulating factor 2

decreases expression
increases expression

Pilocarpine results in decreased expression of CSF2 mRNA
Pilocarpine results in increased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 2 receptor subunit beta

increases expression

Pilocarpine results in increased expression of CSF2RB mRNA

NCBI chr 7:111,756,950...111,782,089
Ensembl chr 7:109,886,425...109,904,157

G

casein beta

decreases expression
increases expression

Pilocarpine results in decreased expression of CSN2 mRNA
Pilocarpine results in increased expression of CSN2 mRNA

NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,322,581...20,329,817

G

cardiotrophin 1

increases expression

Pilocarpine results in increased expression of CTF1 mRNA

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:182,328,090...182,333,335

G

catenin beta 1

increases expression

Pilocarpine results in increased expression of CTNNB1 protein

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

increases expression

Pilocarpine results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

Pilocarpine results in increased expression of CYP11A1 protein

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338

G

death associated protein 3

increases expression

Pilocarpine results in increased expression of DAP3 mRNA

NCBI chr 2:176,617,151...176,645,293
Ensembl chr 2:174,318,983...174,346,461

G

DNA cross-link repair 1A

increases expression

Pilocarpine results in increased expression of DCLRE1A mRNA

NCBI chr 1:265,575,087...265,594,987
Ensembl chr 1:255,569,919...255,589,678

G

DNA-damage inducible transcript 3

increases expression

Pilocarpine results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

dystrophin

decreases expression

Pilocarpine results in decreased expression of DMD protein

NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207

G

dihydropyrimidinase-like 2

increases expression

Pilocarpine results in increased expression of DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:41,005,551...41,111,829

G

dopamine receptor D1

increases expression
multiple interactions
increases response to substance
decreases expression

Pilocarpine results in increased expression of DRD1 mRNA
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine; [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine
DRD1 protein results in increased susceptibility to Pilocarpine
Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]
Pilocarpine results in decreased expression of DRD1 protein

PMID:1365435 PMID:7906944 PMID:14656328 PMID:15876489 PMID:16137708

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
decreases response to substance
decreases activity
decreases expression

[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]
DRD2 protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased activity of DRD2 protein
Pilocarpine results in decreased expression of DRD2 protein

PMID:1365435 PMID:11860278 PMID:14559291 PMID:15140183 PMID:15876489 More...

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

ephrin A3

decreases expression

Pilocarpine results in decreased expression of EFNA3 mRNA

NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:174,729,764...174,738,736

G

epidermal growth factor receptor

decreases expression

Pilocarpine results in decreased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
multiple interactions

Pilocarpine results in increased expression of EGR1 mRNA
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

multiple interactions
increases expression

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

multiple interactions
increases expression

Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
Pilocarpine results in increased expression of EGR3 mRNA; Pilocarpine results in increased expression of EGR3 protein

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627

G

EI24, autophagy associated transmembrane protein

decreases expression

Pilocarpine results in decreased expression of EI24 mRNA

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:36,494,289...36,510,571

G

eukaryotic translation initiation factor 2-alpha kinase 2

multiple interactions

Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein

NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases activity

Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]
Pilocarpine results in increased activity of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]
Pilocarpine results in increased phosphorylation of EIF2S1 protein

PMID:15003282 PMID:16492139

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

EPH receptor A5

decreases expression

Pilocarpine results in decreased expression of EPHA5 mRNA; Pilocarpine results in decreased expression of EPHA5 protein

NCBI chr14:24,007,400...24,374,854
Ensembl chr14:23,653,393...24,017,317

G

erythropoietin

increases expression

Pilocarpine results in increased expression of EPO mRNA

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946

G

erythropoietin receptor

increases expression

Pilocarpine results in increased expression of EPOR mRNA

NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:20,489,678...20,494,257

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

Pilocarpine results in increased expression of ERCC1 mRNA

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 3, TFIIH core complex helicase subunit

increases expression

Pilocarpine results in increased expression of ERCC3 mRNA

NCBI chr18:24,157,831...24,188,543
Ensembl chr18:23,883,580...23,914,329

G

ezrin

increases expression

Pilocarpine results in increased expression of EZR protein

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II, thrombin

increases activity

Pilocarpine results in increased activity of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486

G

fibroblast growth factor 2

multiple interactions

FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 5

increases expression

Pilocarpine results in increased expression of FGF5 mRNA

NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,325,334...11,345,997

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

[Pilocarpine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS protein; [Pilocarpine co-treated with Lithium] results in increased expression of FOS protein; [Pilocarpine co-treated with SCH 23390] results in increased expression of FOS protein; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of FOS mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Pilocarpine results in increased expression of FOS mRNA; Pilocarpine results in increased expression of FOS protein
Pilocarpine results in decreased expression of FOS mRNA

PMID:7713058 PMID:7968354 PMID:7984056 PMID:8281324 PMID:8511714 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Pilocarpine results in increased expression of FOSB protein

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:78,954,115...78,961,465

G

follicle stimulating hormone subunit beta

decreases expression

Pilocarpine results in decreased expression of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions
decreases expression

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression
multiple interactions

Pilocarpine results in increased expression of GABRA4 protein
Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
Pilocarpine results in increased expression of GABRA4 mRNA

PMID:15456836 PMID:16091474

NCBI chr14:36,944,747...37,021,652
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha 5

multiple interactions
decreases expression

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]

NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:108,268,776...108,380,917

G

gamma-aminobutyric acid type A receptor subunit delta

multiple interactions
decreases expression

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]
Pilocarpine results in decreased expression of GABRD protein

PMID:15456836 PMID:20821261

NCBI chr 5:171,240,813...171,252,709
Ensembl chr 5:165,958,484...165,970,411

G

gamma-aminobutyric acid type A receptor subunit gamma 2

increases expression

Pilocarpine results in increased expression of GABRG2 protein

NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346

G

glutamate decarboxylase 1

increases expression

Pilocarpine results in increased expression of GAD1 mRNA

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

affects expression
decreases expression
increases expression

Pilocarpine affects the expression of GAD2 protein
Pilocarpine results in decreased expression of GAD2 protein
Pilocarpine results in increased expression of GAD2 mRNA; Pilocarpine results in increased expression of GAD2 protein

PMID:12183020 PMID:15857427 PMID:15987249 PMID:16797850

NCBI chr17:89,671,718...89,734,246
Ensembl chr17:84,763,628...84,826,155

G

growth associated protein 43

decreases expression
increases expression

Pilocarpine results in decreased expression of GAP43 protein
Pilocarpine results in increased expression of GAP43 mRNA

PMID:15191797 PMID:16134595

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:58,376,371...58,470,045

G

glial cell derived neurotrophic factor

increases expression
multiple interactions

Pilocarpine results in increased expression of GDNF mRNA
[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein

PMID:7854063 PMID:12914250

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

multiple interactions
decreases expression
increases expression

1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]]
Pilocarpine results in decreased expression of GFAP protein

PMID:25101675 PMID:30542433 PMID:31018114

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589

G

gap junction protein, alpha 1

increases expression
affects localization

Pilocarpine results in increased expression of GJA1 protein
Pilocarpine affects the localization of GJA1 protein

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

glutamate dehydrogenase 1

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA]

NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,640,312...9,673,957

G

glutamate-ammonia ligase

decreases expression

Pilocarpine results in decreased expression of GLUL protein

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108

G

glutamic--pyruvic transaminase

increases secretion

Pilocarpine results in increased secretion of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glutamate ionotropic receptor AMPA type subunit 1

decreases expression
increases expression

Pilocarpine results in decreased expression of GRIA1 mRNA
Pilocarpine results in increased expression of GRIA1 protein

PMID:7529610 PMID:15857427

NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor AMPA type subunit 2

multiple interactions
increases expression
decreases expression

[Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA
Pilocarpine results in increased expression of GRIA2 3' UTR alternative form; Pilocarpine results in increased expression of GRIA2 protein
Pilocarpine results in decreased expression of GRIA2 mRNA

PMID:15857427 PMID:16819974 PMID:19222700

NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions
decreases expression
increases expression

[Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA
Pilocarpine results in decreased expression of GRIA3 mRNA
Pilocarpine results in increased expression of GRIA3 mRNA; Pilocarpine results in increased expression of GRIA3 protein

PMID:7529610 PMID:15857427 PMID:16819974

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor kainate type subunit 1

multiple interactions

[Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine

NCBI chr11:40,655,974...41,056,966
Ensembl chr11:27,169,740...27,570,645

G

glutamate ionotropic receptor kainate type subunit 2

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA

NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor kainate type subunit 5

multiple interactions

[Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA

NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions
decreases expression

Plant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA]

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
decreases expression
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]
Pilocarpine results in decreased expression of GRIN2A protein

PMID:15857427 PMID:16600505 PMID:22824136

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression
multiple interactions
increases expression

Pilocarpine results in decreased expression of GRIN2B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]

PMID:15857427 PMID:16600505 PMID:22824136

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279

G

glutamate metabotropic receptor 1

decreases expression
increases expression
multiple interactions

Pilocarpine results in decreased expression of GRM1 protein
Pilocarpine results in increased expression of GRM1 protein
[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of GRM1 mRNA

PMID:11463519 PMID:32494933

NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 2

decreases expression

Pilocarpine results in decreased expression of GRM2 mRNA; Pilocarpine results in decreased expression of GRM2 protein

PMID:16793029 PMID:18585369 PMID:18804094

NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146

G

glutamate metabotropic receptor 3

decreases expression

Pilocarpine results in decreased expression of GRM3 mRNA; Pilocarpine results in decreased expression of GRM3 protein

PMID:16793029 PMID:18585369 PMID:18804094

NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:24,365,115...24,609,804

G

glutamate metabotropic receptor 5

multiple interactions
decreases expression

[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased expression of GRM5 mRNA; Pilocarpine results in decreased expression of GRM5 protein

PMID:15009663 PMID:17634364

NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:141,312,368...141,882,274

G

glutamate metabotropic receptor 8

increases expression
decreases expression

Pilocarpine results in increased expression of GRM8 protein
Pilocarpine results in decreased expression of GRM8

PMID:11226630 PMID:12539201

NCBI chr 4:56,771,247...57,696,951
Ensembl chr 4:55,805,955...56,730,831

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

multiple interactions
decreases expression

[Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA
Pilocarpine results in decreased expression of HCN1 protein

PMID:12890777 PMID:21905079

NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:49,495,771...49,899,774

G

hypoxia inducible factor 1 subunit alpha

increases expression

Pilocarpine results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

increases expression

Pilocarpine results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein]

NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression

Pilocarpine results in increased expression of HMOX1 protein
Pilocarpine results in increased expression of HMOX1 mRNA

PMID:20971094 PMID:25715797 PMID:32234387

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

homeo box B1

decreases expression

Pilocarpine results in decreased expression of HOXB1 mRNA

NCBI chr10:81,827,915...81,830,404
Ensembl chr10:81,331,507...81,332,836

G

harakiri, BCL2 interacting protein

decreases expression

Pilocarpine results in decreased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561

G

heat shock factor binding protein 1

decreases expression

Pilocarpine results in decreased expression of HSBP1 mRNA

NCBI chr19:64,309,703...64,314,035
Ensembl chr19:47,400,966...47,435,821

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein; Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Pilocarpine results in increased expression of HSPB1 mRNA; Pilocarpine results in increased expression of HSPB1 protein

PMID:17971868 PMID:20971094

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

5-hydroxytryptamine receptor 1A

multiple interactions

[8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine; [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine

PMID:2533336 PMID:15140183

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 1B

multiple interactions

[cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine

NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:82,517,360...82,534,549

G

5-hydroxytryptamine receptor 2C

multiple interactions
decreases expression
increases expression

Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]
Pilocarpine results in decreased expression of HTR2C mRNA; Pilocarpine results in decreased expression of HTR2C protein
Pilocarpine results in increased expression of HTR2C mRNA; Pilocarpine results in increased expression of HTR2C protein

PMID:19439326 PMID:19700373

NCBI chr X:115,453,190...115,682,325
Ensembl chr X:110,641,153...110,870,287

G

interferon gamma

multiple interactions
decreases expression

1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein 3

increases expression

Pilocarpine results in increased expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

multiple interactions
increases expression
decreases expression

1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IL10 protein]
Pilocarpine results in increased expression of IL10 protein

PMID:15781040 PMID:17872965

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

increases expression

Pilocarpine results in increased expression of IL12B mRNA

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 beta

multiple interactions
decreases expression
increases expression

[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]
Pilocarpine results in decreased expression of IL1B mRNA
Pilocarpine results in increased expression of IL1B mRNA; Pilocarpine results in increased expression of IL1B protein

PMID:19010416 PMID:19055492 PMID:19951488 PMID:21087489 PMID:23211629 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression

Pilocarpine results in decreased expression of IL2 mRNA

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4 receptor

increases expression

Pilocarpine results in increased expression of IL4R mRNA

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

decreases expression
multiple interactions

Pilocarpine results in decreased expression of IL6 mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 protein

PMID:19055492 PMID:31018114

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

integrin-linked kinase

decreases activity

Pilocarpine results in decreased activity of ILK protein

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:160,088,897...160,095,140

G

inositol monophosphatase 1

increases response to substance
affects response to substance
decreases response to substance

IMPA1 gene mutant form results in increased susceptibility to Pilocarpine
IMPA1 protein affects the susceptibility to Pilocarpine
IMPA1 protein results in decreased susceptibility to Pilocarpine

PMID:17460611 PMID:17602744 PMID:19754464

NCBI chr 2:93,370,200...93,391,474
Ensembl chr 2:91,462,799...91,484,313

G

integrin subunit alpha 1

increases expression

Pilocarpine results in increased expression of ITGA1 protein

NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:46,653,193...46,812,238

G

integrin subunit alpha 2

increases expression

Pilocarpine results in increased expression of ITGA2 protein

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 4

increases expression

Pilocarpine results in increased expression of ITGA4 protein

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha 5

increases expression

Pilocarpine results in increased expression of ITGA5 protein

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit beta 1

decreases expression
increases expression

Pilocarpine results in decreased expression of ITGB1 protein
Pilocarpine results in increased expression of ITGB1 protein

PMID:12851778 PMID:19631748

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 3

increases expression

Pilocarpine results in increased expression of ITGB3 protein

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679

G

integrin subunit beta 4

increases expression

Pilocarpine results in increased expression of ITGB4 protein

NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,206,665...101,243,012

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Lithium co-treated with Pilocarpine] results in increased expression of JUN protein; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUN mRNA]

PMID:7984056 PMID:17971868 PMID:19430551

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

PMID:7968354 PMID:7984056

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

potassium voltage-gated channel subfamily C member 4

decreases expression

Pilocarpine results in decreased expression of KCNC4 mRNA; Pilocarpine results in decreased expression of KCNC4 protein

NCBI chr 2:197,747,095...197,788,467
Ensembl chr 2:195,071,769...195,099,233

G

potassium two pore domain channel subfamily K member 5

increases expression
decreases expression

Pilocarpine results in increased expression of KCNK5 protein
Pilocarpine results in decreased expression of KCNK5 protein

NCBI chr15:4,171,625...4,213,896
Ensembl chr15:4,122,442...4,164,718

G

potassium calcium-activated channel subfamily M alpha 1

decreases expression

Pilocarpine results in decreased expression of KCNMA1 mRNA

NCBI chr15:351,065...1,057,117
Ensembl chr15:302,214...1,001,198

G

potassium calcium-activated channel subfamily N member 1

decreases expression

Pilocarpine results in decreased expression of KCNN1 protein

NCBI chr16:18,608,782...18,632,571
Ensembl chr16:18,585,992...18,597,482

G

potassium calcium-activated channel subfamily N member 2

decreases expression

Pilocarpine results in decreased expression of KCNN2 mRNA; Pilocarpine results in decreased expression of KCNN2 protein

NCBI chr18:40,004,693...40,445,043
Ensembl chr18:37,817,957...38,258,347

G

potassium calcium-activated channel subfamily N member 3

decreases expression

Pilocarpine results in decreased expression of KCNN3 mRNA; Pilocarpine results in decreased expression of KCNN3 protein

NCBI chr 2:177,227,276...177,378,849
Ensembl chr 2:174,936,629...175,081,145

G

lysosomal-associated membrane protein 2

multiple interactions
increases expression

Vitamin E inhibits the reaction [Pilocarpine results in increased expression of LAMP2 protein]
Pilocarpine results in increased expression of LAMP2 mRNA; Pilocarpine results in increased expression of LAMP2 protein

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522

G

luteinizing hormone subunit beta

decreases expression

Pilocarpine results in decreased expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LIF, interleukin 6 family cytokine

increases expression

Pilocarpine results in increased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Pilocarpine results in increased phosphorylation of MAPK1 protein
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]

PMID:12091480 PMID:17360923 PMID:18988310 PMID:19402951 PMID:22824136

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Pilocarpine results in increased phosphorylation of MAPK3 protein
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]

PMID:12091480 PMID:17360923 PMID:18988310 PMID:19402951 PMID:22824136

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases activity

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; W 7 inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

myocyte enhancer factor 2C

increases expression

Pilocarpine results in increased expression of MEF2C mRNA

NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880

G

O-6-methylguanine-DNA methyltransferase

increases expression

Pilocarpine results in increased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 200c

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] results in increased expression of MIR200C mRNA

NCBI chr 4:159,209,965...159,210,033

G

matrix metallopeptidase 9

increases activity
increases expression

Pilocarpine results in increased activity of MMP9 protein
Pilocarpine results in increased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

MRE11 homolog, double strand break repair nuclease

increases expression

Pilocarpine results in increased expression of MRE11A mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279

G

moesin

increases expression

Pilocarpine results in increased expression of MSN mRNA

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:60,995,951...61,065,628

G

mechanistic target of rapamycin kinase

multiple interactions
increases phosphorylation

dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

increases expression

Pilocarpine results in increased expression of MYD88 mRNA

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

NLR family, apoptosis inhibitory protein 6

decreases expression

Pilocarpine results in decreased expression of NAIP2 mRNA

NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:31,507,424...31,570,542

G

nuclear factor of activated T-cells 5

decreases expression

Pilocarpine results in decreased expression of NFAT5 mRNA

NCBI chr19:52,108,982...52,196,418
Ensembl chr19:35,199,016...35,286,675

G

NFE2 like bZIP transcription factor 2

increases expression

Pilocarpine results in increased expression of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases expression
increases phosphorylation
multiple interactions

Pilocarpine results in increased expression of NFKBIA mRNA
Pilocarpine results in increased phosphorylation of NFKBIA protein
resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]

PMID:15193289 PMID:23211629

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions
increases expression

Ketamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]

PMID:8635431 PMID:8821376 PMID:15183516 PMID:17971868

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

increases expression
increases response to substance
multiple interactions

Pilocarpine results in increased expression of NGFR protein
NGFR protein results in increased susceptibility to Pilocarpine
PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]
Pilocarpine results in increased expression of NGFR mRNA; Pilocarpine results in increased expression of NGFR protein

PMID:10436046 PMID:12097334 PMID:18815271 PMID:21084616

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518

G

nitric oxide synthase 1

multiple interactions
increases expression

[Pilocarpine co-treated with Lithium] results in increased expression of NOS1 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein]

PMID:18672383 PMID:20149694

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions
increases expression

[Pilocarpine co-treated with Lithium] results in increased expression of NOS2 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]
Pilocarpine results in increased expression of NOS2 mRNA; Pilocarpine results in increased expression of NOS2 protein

PMID:18672383 PMID:20149694 PMID:23211629

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

NOVA alternative splicing regulator 1

increases expression
multiple interactions

Pilocarpine results in increased expression of NOVA1 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]

NCBI chr 6:69,506,983...69,632,437
Ensembl chr 6:63,783,489...63,906,289

G

NOVA alternative splicing regulator 2

decreases expression
multiple interactions

Pilocarpine results in decreased expression of NOVA2 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]

NCBI chr 1:87,700,328...87,741,755
Ensembl chr 1:78,572,279...78,608,021

G

neuronal pentraxin 2

increases expression

Pilocarpine results in increased expression of NPTX2 mRNA

NCBI chr12:15,151,136...15,162,045
Ensembl chr12:10,037,435...10,048,345

G

neuropeptide Y

decreases response to substance
increases expression

NPY protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in increased expression of NPY protein

PMID:12231234 PMID:12821374 PMID:15451008

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495

G

NAD(P)H quinone dehydrogenase 1

increases expression

Pilocarpine results in increased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 protein]

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

neurotrophin 3

decreases expression
multiple interactions

Pilocarpine results in decreased expression of NTF3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
increases expression

Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]

PMID:8635431 PMID:8821376 PMID:15183516 PMID:19686240

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136

G

neurotrophic receptor tyrosine kinase 3

increases expression
multiple interactions

Pilocarpine results in increased expression of NTRK3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]

NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:132,132,849...132,503,286

G

ornithine decarboxylase 1

increases expression

Pilocarpine results in increased expression of ODC1 mRNA

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440

G

8-oxoguanine DNA glycosylase

decreases expression

Pilocarpine results in decreased expression of OGG1 mRNA; Pilocarpine results in decreased expression of OGG1 protein

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766

G

opioid receptor, kappa 1

decreases response to substance

OPRK1 protein results in decreased susceptibility to Pilocarpine

NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

decreases expression

Pilocarpine results in decreased expression of OPRM1 protein

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409

G

oncostatin M

increases expression

Pilocarpine results in increased expression of OSM mRNA

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313

G

purinergic receptor P2X 7

increases expression

Pilocarpine results in increased expression of P2RX7 protein

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619

G

poly (ADP-ribose) polymerase 1

affects expression
multiple interactions

Pilocarpine affects the expression of PARP1 protein
3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; [Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]

PMID:25101675 PMID:31396050

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

increases expression

Pilocarpine results in increased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

proprotein convertase subtilisin/kexin type 1

increases expression

Pilocarpine results in increased expression of PCSK1 mRNA

NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:4,395,543...4,442,434

G

pyridoxal kinase like 1

increases expression

Pilocarpine results in increased expression of PDXK protein

NCBI chr20:10,162,634...10,192,271
Ensembl chr20:10,164,099...10,192,739

G

proliferation and apoptosis adaptor protein 15

multiple interactions

[Pilocarpine co-treated with Lithium Chloride co-treated with 3-chloroacetylindole] results in decreased phosphorylation of PEA15 protein; [Pilocarpine co-treated with Lithium Chloride] results in decreased phosphorylation of PEA15 protein

NCBI chr13:87,190,189...87,199,811
Ensembl chr13:84,654,870...84,667,499

G

phospholipase C, beta 4

increases expression

Pilocarpine results in increased expression of PLCB4 protein

NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:122,953,196...123,322,392

G

polynucleotide kinase 3'-phosphatase

increases expression

Pilocarpine results in increased expression of PNKP mRNA

NCBI chr 1:104,476,801...104,483,409
Ensembl chr 1:95,341,620...95,346,920

G

pyridoxamine 5'-phosphate oxidase

increases expression

Pilocarpine results in increased expression of PNPO protein

NCBI chr10:82,421,027...82,427,288
Ensembl chr10:81,924,569...81,930,871

G

DNA polymerase gamma, catalytic subunit

increases expression

Pilocarpine results in increased expression of POLG mRNA; Pilocarpine results in increased expression of POLG protein

NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:133,382,766...133,398,567

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Pilocarpine results in increased expression of PPP1R15A protein

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

Pilocarpine results in decreased expression of PPP3R1 mRNA

NCBI chr14:95,758,333...95,808,015
Ensembl chr14:91,604,121...91,606,907

G

protein kinase C, beta

increases expression
decreases expression

Pilocarpine results in increased expression of PRKCB protein
Pilocarpine results in decreased expression of PRKCB mRNA

PMID:15058486 PMID:17971868 PMID:18774262

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

increases expression

Pilocarpine results in increased expression of PRKCD protein

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, gamma

increases expression

Pilocarpine results in increased expression of PRKCG protein

PMID:15058486 PMID:18774262

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384

G

protein kinase C, eta

increases expression

Pilocarpine results in increased expression of PRKCH protein

NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:92,292,000...92,490,654

G

protein kinase C, zeta

increases expression

Pilocarpine results in increased expression of PRKCZ protein

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367

G

phosphatase and tensin homolog

multiple interactions

PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E synthase

increases expression

Pilocarpine results in increased expression of PTGES mRNA

NCBI chr 3:34,575,643...34,586,987

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Pilocarpine results in increased expression of PTGS2 mRNA
Pilocarpine results in increased expression of PTGS2 mRNA; Pilocarpine results in increased expression of PTGS2 protein
resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]

PMID:15193289 PMID:23211629

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions
increases phosphorylation

[Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein
Pilocarpine results in increased phosphorylation of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine kinase 2 beta

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282

G

protein tyrosine phosphatase, non-receptor type 5

multiple interactions
decreases response to substance

PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PTPN5 protein mutant form results in decreased susceptibility to Pilocarpine

PMID:17360923 PMID:21204826

NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882

G

protein tyrosine phosphatase, receptor type Z1

affects expression

Pilocarpine affects the expression of PTPRZ1 protein

NCBI chr 4:52,363,006...52,560,905
Ensembl chr 4:51,397,601...51,595,218

G

parvalbumin

decreases expression

Pilocarpine results in decreased expression of PVALB protein

NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:109,772,593...109,784,561

G

quinoid dihydropteridine reductase

increases expression

Pilocarpine results in increased expression of QDPR protein

NCBI chr14:69,882,776...69,896,378
Ensembl chr14:65,670,131...65,683,854

G

RAD23 homolog A, nucleotide excision repair protein

increases expression
decreases expression

Pilocarpine results in increased expression of RAD23A mRNA
Pilocarpine results in decreased expression of RAD23A mRNA

NCBI chr19:40,219,235...40,225,543
Ensembl chr19:23,314,797...23,320,695

G

RAD23 homolog B, nucleotide excision repair protein

increases expression

Pilocarpine results in increased expression of RAD23B mRNA

NCBI chr 5:74,885,518...74,923,621
Ensembl chr 5:70,090,232...70,128,319

G

reversion-inducing-cysteine-rich protein with kazal motifs

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK mRNA; [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK protein

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:58,102,981...58,169,502

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; [Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ret proto-oncogene

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased expression of RET protein

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176

G

ribosomal protein L32

multiple interactions

Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]

NCBI chr 4:150,536,650...150,540,214
Ensembl chr 4:148,864,044...148,867,612
Ensembl chr 3:148,864,044...148,867,612

G

ribosomal protein S6

multiple interactions
increases phosphorylation

dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

S100 calcium binding protein B

increases expression

Pilocarpine results in increased expression of S100B protein

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,881...12,394,743

G

sodium voltage-gated channel beta subunit 2

decreases response to substance

SCN2B protein results in decreased susceptibility to Pilocarpine

NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:45,425,629...45,437,765

G

sodium voltage-gated channel alpha subunit 8

increases expression

Pilocarpine results in increased expression of SCN8A mRNA; Pilocarpine results in increased expression of SCN8A protein

NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292

G

sirtuin 1

multiple interactions
increases expression

dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Niacinamide inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 12 member 2

increases expression

Pilocarpine results in increased expression of SLC12A2 mRNA; Pilocarpine results in increased expression of SLC12A2 protein

PMID:18550034 PMID:19674083

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 12 member 5

decreases expression
increases degradation
multiple interactions

Pilocarpine results in decreased expression of SLC12A5 mRNA; Pilocarpine results in decreased expression of SLC12A5 protein
Pilocarpine results in increased degradation of SLC12A5 protein
Pilocarpine results in increased phosphorylation of and affects the localization of SLC12A5 protein

PMID:18094240 PMID:18550034 PMID:19674083 PMID:20600929

NCBI chr 3:174,115,833...174,155,112
Ensembl chr 3:153,696,517...153,735,765

G

solute carrier family 17 member 7

increases expression

Pilocarpine results in increased expression of SLC17A7 protein

NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 1 member 1

increases expression

Pilocarpine results in increased expression of SLC1A1 mRNA; Pilocarpine results in increased expression of SLC1A1 protein

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 22 member 2

multiple interactions

Pilocarpine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 32 member 1

increases expression

Pilocarpine results in increased expression of SLC32A1 mRNA; Pilocarpine results in increased expression of SLC32A1 protein

NCBI chr 3:167,687,245...167,691,714
Ensembl chr 3:147,267,373...147,271,844

G

solute carrier family 5 member 3

increases response to substance
affects response to substance
increases expression

SLC5A3 gene mutant form results in increased susceptibility to Pilocarpine
SLC5A3 protein affects the susceptibility to Pilocarpine
Pilocarpine results in increased expression of SLC5A3 mRNA

PMID:17602744 PMID:19754464 PMID:21219332

NCBI chr11:44,799,787...44,802,233
Ensembl chr11:31,295,476...31,318,883

G

solute carrier family 6 member 1

decreases expression

Pilocarpine results in decreased expression of SLC6A1 protein
Pilocarpine results in decreased expression of SLC6A1 mRNA

PMID:12183020 PMID:21219332

NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:147,466,965...147,482,293

G

solute carrier family 6 member 11

decreases expression

Pilocarpine results in decreased expression of SLC6A11 mRNA

NCBI chr 4:148,853,557...148,968,895
Ensembl chr 4:147,297,969...147,413,443

G

solute carrier family 6 member 12

decreases expression
increases expression

Pilocarpine results in decreased expression of SLC6A12 mRNA
Pilocarpine results in increased expression of SLC6A12 mRNA

NCBI chr 4:156,257,518...156,275,870
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 6 member 6

increases expression

Pilocarpine results in increased expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier organic anion transporter family, member 1a4

decreases expression

Pilocarpine results in decreased expression of SLCO1A4 protein

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573

G

slit guidance ligand 2

increases expression
decreases expression

Pilocarpine results in increased expression of SLIT2 protein
Pilocarpine results in decreased expression of SLIT2 protein

NCBI chr14:66,829,661...67,168,517
Ensembl chr14:62,617,067...62,955,948

G

structural maintenance of chromosomes 3

increases expression

Pilocarpine results in increased expression of SMC3 mRNA

NCBI chr 1:262,606,731...262,649,832
Ensembl chr 1:252,601,753...252,644,522

G

syntrophin, alpha 1

decreases expression

Pilocarpine results in decreased expression of SNTA1 protein

NCBI chr 3:163,336,509...163,366,954
Ensembl chr 3:142,876,296...142,906,709

G

superoxide dismutase 2

increases expression

Pilocarpine results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

SPARC like 1

affects localization
decreases expression

Pilocarpine affects the localization of SPARCL1 protein
Pilocarpine results in decreased expression of SPARCL1 protein

PMID:18488994 PMID:18808451

NCBI chr14:5,937,484...5,968,532
Ensembl chr14:5,632,569...5,663,865

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased activity of SRC protein

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

somatostatin receptor 1

increases expression

Pilocarpine results in increased expression of SSTR1 protein

NCBI chr 6:81,567,237...81,571,759
Ensembl chr 6:75,832,530...75,836,802

G

somatostatin receptor 2

increases expression

Pilocarpine results in increased expression of SSTR2 protein

NCBI chr10:99,163,353...99,170,519
Ensembl chr10:98,664,216...98,674,351

G

somatostatin receptor 3

decreases expression

Pilocarpine results in decreased expression of SSTR3 protein

NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:110,092,575...110,099,769

G

somatostatin receptor 4

decreases expression
increases expression

Pilocarpine results in decreased expression of SSTR4 protein
Pilocarpine results in increased expression of SSTR4 protein

NCBI chr 3:156,307,992...156,309,855
Ensembl chr 3:135,854,826...135,856,689

G

somatostatin receptor 5

decreases expression
increases expression

Pilocarpine results in decreased expression of SSTR5 protein
Pilocarpine results in increased expression of SSTR5 protein

NCBI chr10:15,010,209...15,017,469
Ensembl chr10:14,506,868...14,512,946

G

steroidogenic acute regulatory protein

increases localization

Pilocarpine results in increased localization of STAR protein

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672

G

StAR-related lipid transfer domain containing 6

increases localization
increases expression

Pilocarpine results in increased localization of STARD6 protein
Pilocarpine results in increased expression of STARD6 protein

PMID:19434006 PMID:20609383

NCBI chr18:66,365,526...66,393,439
Ensembl chr18:64,089,471...64,107,099

G

synaptophysin

increases expression

Pilocarpine results in increased expression of SYP protein

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

tachykinin, precursor 1

multiple interactions

[Pilocarpine co-treated with Lithium] results in increased expression of TAC1 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 protein modified form; Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form]

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

thymine-DNA glycosylase

increases expression

Pilocarpine results in increased expression of TDG mRNA

NCBI chr 7:22,965,388...22,990,311
Ensembl chr 7:21,077,853...21,097,567

G

transcription factor A, mitochondrial

increases expression

Pilocarpine results in increased expression of TFAM mRNA; Pilocarpine results in increased expression of TFAM protein

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292

G

thyroid hormone receptor beta

increases expression

Pilocarpine results in increased expression of THRB mRNA

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916

G

TIMP metallopeptidase inhibitor 2

increases expression

Pilocarpine results in increased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

G

tight junction protein 1

decreases expression

Pilocarpine results in decreased expression of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 2

increases expression

Pilocarpine results in increased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of TLR4 mRNA]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tenascin C

increases expression

Pilocarpine results in increased expression of TNC mRNA

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

increases expression
multiple interactions
decreases expression

Pilocarpine results in increased expression of TNF mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF protein; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of TNF protein]
Pilocarpine results in decreased expression of TNF mRNA; Pilocarpine results in decreased expression of TNF protein

PMID:15193289 PMID:17872965 PMID:18455351 PMID:19055492 PMID:31018114

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

Pilocarpine results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

decreases expression

Pilocarpine results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 13

decreases expression

Pilocarpine results in decreased expression of TNFSF13 mRNA

NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,400,065...54,403,042

G

tenascin R

increases expression

Pilocarpine results in increased expression of TNR protein

NCBI chr13:74,285,141...74,706,174
Ensembl chr13:72,091,585...72,167,641

G

three prime repair exonuclease 1

increases expression

Pilocarpine results in increased expression of TREX1 mRNA

NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796

G

thyrotropin releasing hormone

increases expression

Pilocarpine results in increased expression of TRH mRNA

PMID:10443546 PMID:15781040

NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:124,742,111...124,744,637

G

thyrotropin releasing hormone receptor

decreases activity
decreases expression

Pilocarpine results in decreased activity of TRHR protein
Pilocarpine results in decreased expression of TRHR protein

NCBI chr 7:77,233,175...77,277,988
Ensembl chr 7:75,348,672...75,393,309

G

ubiquitin-conjugating enzyme E2D 3

increases expression

Pilocarpine results in increased expression of UBE2D3 mRNA

NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:223,868,730...223,898,081

G

ubiquitin-conjugating enzyme E2I

increases expression

Pilocarpine results in increased expression of UBE2I mRNA

NCBI chr10:14,782,245...14,802,911
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

vitamin D receptor

increases expression

Pilocarpine results in increased expression of VDR mRNA

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

increases expression

Pilocarpine results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

VGF nerve growth factor inducible

increases expression

Pilocarpine results in increased expression of VGF mRNA

NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341

G

X-ray repair cross complementing 1

increases expression

Pilocarpine results in increased expression of XRCC1 mRNA

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 3

increases expression

Pilocarpine results in increased expression of XRCC3 mRNA

NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:130,863,959...130,872,444

G

zinc finger protein 110

multiple interactions

ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]

NCBI chr 1:82,509,563...82,533,294
Ensembl chr 1:73,445,336...73,461,086

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19887
role	19858
application	19697
pharmaceutical	19534
drug	19534
ophthalmology drug	435
antiglaucoma drug	421
(+)-pilocarpine	302
pilocarpine hydrochloride	0
Path 2
Term	Annotations
CHEBI ontology	19887
subatomic particle	19885
composite particle	19885
hadron	19885
baryon	19885
nucleon	19885
atomic nucleus	19885
atom	19885
main group element atom	19824
p-block element atom	19824
carbon group element atom	19763
carbon atom	19760
organic molecular entity	19760
heteroorganic entity	19521
organochalcogen compound	19282
organooxygen compound	19197
ester	17562
carboxylic ester	16963
lactone	13299
gamma-lactone	6859
butan-4-olide	308
xi,xi-pilocarpine	302
pilocarpine	302
(+)-pilocarpine	302
pilocarpine hydrochloride	0

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