Ccr8 (C-C motif chemokine receptor 8) - Rat Genome Database

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Gene: Ccr8 (C-C motif chemokine receptor 8) Rattus norvegicus
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Symbol: Ccr8
Name: C-C motif chemokine receptor 8
RGD ID: 1304893
Description: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis. Predicted to be active in external side of plasma membrane. Biomarker of asthma and pulmonary fibrosis. Orthologous to human CCR8 (C-C motif chemokine receptor 8); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C chemokine receptor type 8; chemokine (C-C motif) receptor 8; LOC301066
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,703,966 - 128,705,926 (+)NCBIGRCr8
mRatBN7.28119,826,332 - 119,828,292 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,826,568 - 119,827,629 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08128,779,552 - 128,782,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,781,395 - 128,782,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,980,462 - 127,983,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,075,457 - 125,076,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,095,193 - 125,096,255 (+)NCBI
Celera8118,970,968 - 118,973,947 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
Additional References at PubMed
PMID:9670926   PMID:31314754  


Genomics

Comparative Map Data
Ccr8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,703,966 - 128,705,926 (+)NCBIGRCr8
mRatBN7.28119,826,332 - 119,828,292 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,826,568 - 119,827,629 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08128,779,552 - 128,782,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,781,395 - 128,782,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,980,462 - 127,983,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,075,457 - 125,076,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18125,095,193 - 125,096,255 (+)NCBI
Celera8118,970,968 - 118,973,947 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38339,329,709 - 39,333,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl339,329,709 - 39,333,680 (+)EnsemblGRCh38hg38GRCh38
GRCh37339,371,200 - 39,375,171 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36339,346,219 - 39,351,077 (+)NCBINCBI36Build 36hg18NCBI36
Build 34339,346,218 - 39,351,077NCBI
Celera339,312,784 - 39,316,758 (+)NCBICelera
Cytogenetic Map3p22.1NCBI
HuRef339,414,545 - 39,418,520 (+)NCBIHuRef
CHM1_1339,322,282 - 39,326,257 (+)NCBICHM1_1
T2T-CHM13v2.0339,342,606 - 39,346,577 (+)NCBIT2T-CHM13v2.0
Ccr8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,921,199 - 119,923,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,921,180 - 119,923,972 (+)EnsemblGRCm39 Ensembl
GRCm389120,092,133 - 120,094,906 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,092,114 - 120,094,906 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,001,251 - 120,004,024 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,940,831 - 119,943,604 (+)NCBIMGSCv36mm8
Celera9120,561,813 - 120,564,500 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map971.39NCBI
Ccr8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,644,479 - 24,691,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,646,358 - 24,690,580 (-)NCBIChiLan1.0ChiLan1.0
CCR8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2239,287,566 - 39,291,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1339,292,328 - 39,296,297 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0339,232,185 - 39,236,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,513,153 - 39,517,077 (+)NCBIpanpan1.1PanPan1.1panPan2
CCR8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1239,013,242 - 9,019,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl239,018,060 - 9,018,589 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,049,245 - 9,054,989 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0239,298,398 - 9,304,140 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl239,302,701 - 9,303,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,111,800 - 9,117,552 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,254,429 - 9,260,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0239,248,048 - 9,253,796 (+)NCBIUU_Cfam_GSD_1.0
Ccr8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,451,898 - 195,452,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,590,471 - 28,591,538 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,590,471 - 28,591,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1324,012,708 - 24,013,775 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,994,097 - 24,014,849 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,225,651 - 26,275,438 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,215 - 87,282 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1583,495 - 84,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660638,808,510 - 8,809,787 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccr8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247311,634,562 - 1,635,629 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247311,634,460 - 1,635,629 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccr8
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000029766
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 17 9 24 37 9 23 9 6 72 44 2 8 17 28

Sequence


Ensembl Acc Id: ENSRNOT00000029766   ⟹   ENSRNOP00000029724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8119,826,568 - 119,827,629 (+)Ensembl
Rnor_6.0 Ensembl8128,781,395 - 128,782,456 (+)Ensembl
RefSeq Acc Id: NM_001427325   ⟹   NP_001414254
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,703,966 - 128,705,926 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414254 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029724.1
Ensembl Acc Id: ENSRNOP00000029724   ⟸   ENSRNOT00000029766
RefSeq Acc Id: NP_001414254   ⟸   NM_001427325
- UniProtKB: D4ADE0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADE0-F1-model_v2 AlphaFold D4ADE0 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304893 AgrOrtholog
BioCyc Gene G2FUF-28761 BioCyc
Ensembl Genes ENSRNOG00000026759 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029766.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  CC_8_rcpt UniProtKB/TrEMBL
  Chmkine_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
NCBI Gene 301066 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 8 UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Ccr8 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER8 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026759 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D4ADE0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr8  C-C motif chemokine receptor 8  Ccr8  chemokine (C-C motif) receptor 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ccr8  chemokine (C-C motif) receptor 8   Ccr8_predicted  chemokine (C-C motif) receptor 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ccr8_predicted  chemokine (C-C motif) receptor 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED