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Gene: Trex1 (three prime repair exonuclease 1) Rattus norvegicus
Symbol: Trex1
Name: three prime repair exonuclease 1
RGD ID: 1311998
Description: Predicted to have several functions, including DNA binding activity; WW domain binding activity; and mismatch repair complex binding activity. Predicted to be involved in several processes, including DNA metabolic process; cell cycle checkpoint; and immunoglobulin mediated immune response. Predicted to localize to several cellular components, including nuclear replication fork; oligosaccharyltransferase complex; and protein-DNA complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1); PARTICIPATES IN DNA replication pathway; G2/M DNA damage checkpoint pathway; INTERACTS WITH (+)-pilocarpine; 1-chloro-2,4-dinitrobenzene; 2,4-dinitrotoluene.
Type: protein-coding
Also known as: LOC301014; MGC109019; RGD1309596; three-prime repair exonuclease 1
Homo sapiens (human) : TREX1 (three prime repair exonuclease 1)  HGNC  Alliance
Mus musculus (house mouse) : Trex1 (three prime repair exonuclease 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trex1 (three prime repair exonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TREX1 (three prime repair exonuclease 1)
Canis lupus familiaris (dog) : TREX1 (three prime repair exonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trex1 (three prime repair exonuclease 1)
Sus scrofa (pig) : TREX1 (three prime repair exonuclease 1)
Chlorocebus sabaeus (African green monkey) : TREX1 (three prime repair exonuclease 1)
Heterocephalus glaber (naked mole-rat) : Trex1 (three prime repair exonuclease 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08117,796,127 - 117,797,427 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,796,128 - 117,797,427 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,147,872 - 117,149,172 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,071,508 - 114,072,509 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18114,092,776 - 114,106,801 (-)NCBI
Celera8108,998,058 - 108,999,059 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Trex1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311998
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.