Fgf5 (fibroblast growth factor 5)

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Gene: Fgf5 (fibroblast growth factor 5) Rattus norvegicus

Analyze

Symbol:

Fgf5

Name:

fibroblast growth factor 5

RGD ID:

620129

Description:

Enables growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within glial cell differentiation and signal transduction involved in regulation of gene expression. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in familial isolated trichomegaly. Orthologous to human FGF5 (fibroblast growth factor 5); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

FGF-5; Fgf3a; fibroblast growth factor 3a; fibroblast growth factor FGF-5; HBGF-5; heparin-binding growth factor 5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FGF5 (fibroblast growth factor 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fgf5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fgf5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FGF5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fgf5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FGF5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FGF5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fgf5 (fibroblast growth factor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LAMC1 (laminin subunit gamma 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Fgf5 (fibroblast growth factor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FGF5 (fibroblast growth factor 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fgf5 (fibroblast growth factor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	bnl	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	let-756	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	fgf5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Allele / Splice:

Fgf5^em1Mcwi Fgf5^em5Mcwi

Genetic Models:

SS-Fgf5^em5Mcwi SS-Fgf5^em1Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	11,323,827 - 11,346,164 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	11,325,334 - 11,345,997 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	11,282,923 - 11,303,718 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	12,582,771 - 12,603,558 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	11,280,357 - 11,301,023 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	12,974,921 - 12,996,046 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	12,974,921 - 12,995,584 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	12,917,742 - 12,938,879 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	12,713,971 - 12,734,634 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	12,713,970 - 12,734,634 (-)	NCBI
Celera	14	11,401,200 - 11,421,848 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

familial isolated trichomegaly (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

1-nitropyrene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetic acid (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

colforsin daropate hydrochloride (EXP)

curcumin (ISO)

cypermethrin (ISO)

decabromodiphenyl ether (EXP)

dioxygen (ISO)

doxorubicin (ISO)

fluoranthene (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

heparin (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

kainic acid (EXP)

kojic acid (ISO)

lipopolysaccharide (ISO)

melphalan (ISO)

methimazole (EXP)

nickel sulfate (ISO)

paclitaxel (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenytoin (ISO)

serotonin (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

suramin (ISO)

tebuconazole (ISO)

tetrachloromethane (EXP)

valproic acid (ISO)

valsartan (ISO)

warfarin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ morphogenesis (IBA)

cell differentiation (IBA)

fibroblast growth factor receptor signaling pathway (IBA,IEA,ISO)

glial cell differentiation (IEA,ISO)

positive regulation of cell division (IEA)

positive regulation of cell population proliferation (IBA,IEA,ISO)

positive regulation of gene expression (IBA)

positive regulation of protein phosphorylation (IBA)

regulation of cell migration (IBA)

signal transduction involved in regulation of gene expression (IEA,ISO)

Cellular Component

cytoplasm (IBA)

extracellular space (IBA)

Molecular Function

fibroblast growth factor receptor binding (IBA,IEA,ISO)

growth factor activity (IBA,IDA,IEA)

nerve growth factor receptor binding (TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

melanoma pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5.	Hattori Y, etal., Biochim Biophys Acta 1996 Apr 10;1306(1):31-3.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation.	Ota Y, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):169-76.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3211147	PMID:8386828	PMID:8663044	PMID:12878680	PMID:18462699

Genomics

Comparative Map Data

Fgf5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	11,323,827 - 11,346,164 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	11,325,334 - 11,345,997 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	11,282,923 - 11,303,718 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	12,582,771 - 12,603,558 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	11,280,357 - 11,301,023 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	12,974,921 - 12,996,046 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	12,974,921 - 12,995,584 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	12,917,742 - 12,938,879 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	12,713,971 - 12,734,634 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	12,713,970 - 12,734,634 (-)	NCBI
Celera	14	11,401,200 - 11,421,848 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

FGF5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	80,266,588 - 80,291,017 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	80,266,639 - 80,336,680 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	81,187,742 - 81,212,171 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	81,406,766 - 81,431,195 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	81,545,010 - 81,569,338	NCBI
Celera	4	78,481,246 - 78,505,675 (+)	NCBI		Celera
Cytogenetic Map	4	q21.21	NCBI
HuRef	4	76,931,809 - 76,956,071 (+)	NCBI		HuRef
CHM1_1	4	81,164,236 - 81,188,666 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	83,596,964 - 83,621,396 (+)	NCBI		T2T-CHM13v2.0

Fgf5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	98,402,108 - 98,424,892 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	98,402,043 - 98,424,889 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	98,254,184 - 98,277,033 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	98,254,184 - 98,277,030 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	98,683,203 - 98,706,049 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	98,494,486 - 98,517,332 (+)	NCBI		MGSCv36	mm8
Celera	5	95,578,008 - 95,600,874 (+)	NCBI		Celera
Cytogenetic Map	5	E3	NCBI
cM Map	5	47.77	NCBI

Fgf5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	4,521,112 - 4,542,061 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	4,521,566 - 4,540,672 (+)	NCBI	ChiLan1.0	ChiLan1.0

FGF5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	4,508,810 - 4,529,449 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	4,508,217 - 4,528,915 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	37,352,539 - 37,372,398 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	4,533,042 - 4,556,071 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	4,532,937 - 4,554,671 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	4,572,084 - 4,591,201 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	4,469,686 - 4,489,573 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	35,474,935 - 35,494,799 (-)	NCBI		UU_Cfam_GSD_1.0

Fgf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	7,816,625 - 7,838,731 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936749	1,741,519 - 1,761,831 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936749	1,741,425 - 1,761,799 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGF5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	137,532,260 - 137,554,458 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	137,531,806 - 137,554,512 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	146,680,375 - 146,702,212 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FGF5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	28,691,320 - 28,714,770 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	28,692,330 - 28,714,887 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	7,142,391 - 7,166,677 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fgf5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	10,713,646 - 10,733,711 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	10,714,970 - 10,734,799 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fgf5
152 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	37
Count of miRNA genes:	36
Interacting mature miRNAs:	37
Transcripts:	ENSRNOT00000035446
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat

Markers in Region

Fgf5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	11,325,420 - 11,325,597 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,975,008 - 12,975,184	NCBI	Rnor6.0
Rnor_5.0	14	12,917,829 - 12,918,005	UniSTS	Rnor5.0
RGSC_v3.4	14	12,714,058 - 12,714,234	UniSTS	RGSC3.4
Celera	14	11,401,287 - 11,401,463	UniSTS
Cytogenetic Map	14	p22	UniSTS

M37823

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	11,345,648 - 11,345,846 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,995,236 - 12,995,433	NCBI	Rnor6.0
Rnor_5.0	14	12,938,057 - 12,938,254	UniSTS	Rnor5.0
RGSC_v3.4	14	12,734,286 - 12,734,483	UniSTS	RGSC3.4
Celera	14	11,421,500 - 11,421,697	UniSTS
Cytogenetic Map	14	p22	UniSTS

Genetic Models

This gene Fgf5 is modified in the following models/strains

SS-Fgf5^em5Mcwi

SS-Fgf5^em1Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium								2
Low	8	9	8		8	1	1	52		19		1
Below cutoff	14	13	8	3	8	5	6	14	10	7	2	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001412336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D64085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D64086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LR130375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000035446 ⟹ ENSRNOP00000029046

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	11,325,334 - 11,345,997 (-)	Ensembl
Rnor_6.0 Ensembl	14	12,974,921 - 12,995,584 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000077861 ⟹ ENSRNOP00000074979

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	12,975,252 - 12,995,584 (-)	Ensembl

RefSeq Acc Id:

NM_001412336 ⟹ NP_001399265

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	11,323,827 - 11,346,164 (-)	NCBI

RefSeq Acc Id:

NM_022211 ⟹ NP_071547

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	11,323,827 - 11,346,164 (-)	NCBI
Rnor_6.0	14	12,974,921 - 12,995,584 (-)	NCBI
Rnor_5.0	14	12,917,742 - 12,938,879 (-)	NCBI
RGSC_v3.4	14	12,713,971 - 12,734,634 (-)	RGD
Celera	14	11,401,200 - 11,421,848 (-)	RGD

Sequence:

show sequence

ATGAGCCTGTCCTTGCTCTTCCTCATCTTCTGCAGCCACCTGATCCTCAGCGCTCCGGCTCAAG
GGGAGAAGCGTCTCACTCCCGAAGGGCAACCCGCGCCTCCTAGGAACCCGGGAGACTCCAGCGG
CAGCCGGGGCAGAAGTAGCGCGACGTTTGCTTCGTCTTCTGCCTCTTCCCCAGTCGCAGCTTCT
CCGGGCAGCCAAGGAAGCGGCTCGGAGCACAGCAGTTTCCAGTGGAGCCCTTCGGGGCGCCGGA
CCGGCAGCCTGTACTGCAGAGTGGGCATCGGTTTCCATCTGCAGATCTACCCGGATGGCAAAGT
CAATGGATCCCACGAAGCCAGTGTGTTAAGTATTTTGGAAATATTTGCTGTGTCTCAGGGGATT
GTAGGAATACGAGGAGTTTTCAGCAACAAATTTTTAGCGATGTCAAAAAAAGGAAAACTCCATG
CAAGTGCCAAATTTACAGATGACTGTAAGTTCAGGGAGAGATTCCAAGAAAACAGCTATAATAC
CTATGCGTCAGCGATTCACAGAACTGAAAAGACAGGCCGGGAGTGGTATGTGGCCCTGAACAAG
AGAGGGAAAGCCAAAAGAGGCTGCAGCCCACGGGTCAAACCCCAGCACGTCTCCACCCACTTCC
TACCCAGGTTCAAGCAGTCCGAGCAACCGGAACTTTCCTTCACCGTCACTGTTCCAGAAAAGAA
AAAGCCACCTAGGCCCTGGAAACCAAAGGTTCCCCTGTCGCCATCTCGTAGAAGCCCCAGTCCA
GTGAAGTACAGACTGAAGTTTCGCTTCGGATGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001399265	(Get FASTA)	NCBI Sequence Viewer
	NP_071547	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA10966	(Get FASTA)	NCBI Sequence Viewer
	BAA10967	(Get FASTA)	NCBI Sequence Viewer
	EDL99619	(Get FASTA)	NCBI Sequence Viewer
	P48807	(Get FASTA)	NCBI Sequence Viewer
	VDK10955	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071547 ⟸ NM_022211
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q63402 (UniProtKB/Swiss-Prot), P48807 (UniProtKB/Swiss-Prot), G3V8W5 (UniProtKB/TrEMBL), A6K649 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLSLLFLIFCSHLILSAPAQGEKRLTPEGQPAPPRNPGDSSGSRGRSSATFASSSASSPVAAS PGSQGSGSEHSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEASVLSILEIFAVSQGI VGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNK RGKAKRGCSPRVKPQHVSTHFLPRFKQSEQPELSFTVTVPEKKKPPRPWKPKVPLSPSRRSPSP VKYRLKFRFG hide sequence

RefSeq Acc Id:

ENSRNOP00000029046 ⟸ ENSRNOT00000035446

RefSeq Acc Id:

ENSRNOP00000074979 ⟸ ENSRNOT00000077861

RefSeq Acc Id:	NP_001399265 ⟸ NM_001412336
- Peptide Label:	isoform 2 precursor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P48807-F1-model_v2	AlphaFold	P48807	1-266	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620129	AgrOrtholog
BioCyc Gene	G2FUF-16360	BioCyc
Ensembl Genes	ENSRNOG00000022631	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000029046	ENTREZGENE
	ENSRNOP00000029046.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000035446	ENTREZGENE
	ENSRNOT00000035446.3	UniProtKB/TrEMBL
Gene3D-CATH	2.80.10.50	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Fibroblast_GF_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IL1/FGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:60662	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	60662	ENTREZGENE
PANTHER	PTHR11486	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11486:SF23	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	FGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fgf5	PhenoGen
PRINTS	HBGFFGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IL1HBGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HBGF_FGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	FGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50353	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6K649	ENTREZGENE, UniProtKB/TrEMBL
	FGF5_RAT	UniProtKB/Swiss-Prot
	G3V8W5	ENTREZGENE, UniProtKB/TrEMBL
	P48807	ENTREZGENE
	Q63402	ENTREZGENE
UniProt Secondary	Q63402	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Fgf5	fibroblast growth factor 5		fibroblast growth factor FGF-5	Name updated	1299863	APPROVED
2002-08-07	Fgf5	fibroblast growth factor FGF-5			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the embryo and adult brain	632714
gene_protein	266 amino acids	632714
gene_transcript	consists of three exons	632714

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)