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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:xi,xi-pilocarpine
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Accession:CHEBI:39460 term browser browse the term
Definition:A butan-4-olide that has formula C11H16N2O2.
Synonyms:exact_synonym: 3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
 related_synonym: Formula=C11H16N2O2;   InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3;   InChIKey=QCHFTSOMWOSFHM-UHFFFAOYSA-N;   SMILES=CCC1C(COC1=O)Cc1cncn1C
 xref: Beilstein:86186


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(+)-pilocarpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Pilocarpine results in increased expression of A2M mRNA CTD PMID:17971868 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression
increases expression
EXP Pilocarpine affects the expression of ABCB1A mRNA
Pilocarpine results in increased expression of ABCB1A mRNA; Pilocarpine results in increased expression of ABCB1A protein
CTD PMID:14706787 PMID:17437408 PMID:19055492 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects expression
increases expression
EXP Pilocarpine affects the expression of ABCB1B mRNA
Pilocarpine results in increased expression of ABCB1B mRNA; Pilocarpine results in increased expression of ABCB1B protein
CTD PMID:14706787 PMID:19055492 PMID:19570321 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects expression EXP Pilocarpine affects the expression of ABCC1 mRNA CTD PMID:19055492 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Pilocarpine results in increased expression of ABCC2 protein CTD PMID:16504477 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 affects expression EXP Pilocarpine affects the expression of ABCC5 mRNA CTD PMID:19055492 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE protein] CTD PMID:32494933 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
increases expression
decreases expression
EXP
ISO
Pilocarpine results in decreased activity of ACHE protein
garcinielliptone FC inhibits the reaction [Pilocarpine results in decreased activity of ACHE protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]; [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
Pilocarpine results in increased expression of ACHE mRNA alternative form; Pilocarpine results in increased expression of ACHE protein alternative form
CTD PMID:16481111 PMID:18242586 PMID:18333967 PMID:19669875 PMID:19932735 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Actb actin, beta multiple interactions ISO Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein] CTD PMID:16492139 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP [2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine CTD PMID:11311893 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pilocarpine CTD PMID:19488739 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Pilocarpine CTD PMID:19125850 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Agrn agrin increases expression EXP Pilocarpine results in increased expression of AGRN protein CTD PMID:17971868 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A protein] CTD PMID:32494933 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of AGTR2 mRNA CTD PMID:32494933 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP Pilocarpine results in increased expression of AIF1 protein CTD PMID:18226170 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akap5 A-kinase anchoring protein 5 increases response to substance ISO AKAP5 protein mutant form results in increased susceptibility to Pilocarpine CTD PMID:18711127 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Pilocarpine results in decreased phosphorylation of AKT1 protein
1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Pilocarpine results in decreased phosphorylation of AKT1 protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased phosphorylation of AKT1 protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Pilocarpine results in decreased phosphorylation of AKT1 protein]]
CTD PMID:19429016 PMID:30542433 PMID:31018114 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase decreases expression
decreases activity
multiple interactions
EXP
ISO
Pilocarpine results in decreased expression of ALAD protein
Pilocarpine results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]
Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]; Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]
CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:25490531 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Ank3 ankyrin 3 increases expression EXP Pilocarpine results in increased expression of ANK3 mRNA; Pilocarpine results in increased expression of ANK3 protein CTD PMID:19306853 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression
affects localization
decreases expression
EXP Pilocarpine results in increased expression of APEX1 mRNA
Pilocarpine affects the localization of APEX1 mRNA
Pilocarpine results in decreased expression of APEX1 protein
CTD PMID:17971868 PMID:20206232 PMID:20446108 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression EXP Pilocarpine results in decreased expression of APLP1 mRNA CTD PMID:19448684 NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155
JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Pilocarpine results in decreased expression of AQP4 protein CTD PMID:20886625 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Aqp5 aquaporin 5 multiple interactions
affects localization
ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Pilocarpine results in decreased expression of ASIC1 mRNA CTD PMID:11162239 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Pilocarpine results in decreased expression of ASIC2 mRNA alternative form CTD PMID:11162239 NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions
increases expression
EXP [Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein
Pilocarpine results in increased expression of ATF2 mRNA
CTD PMID:17971868 PMID:19430551 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Pilocarpine results in increased expression of ATP2A2 protein CTD PMID:15288437 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression EXP Pilocarpine results in increased expression of ATRX mRNA CTD PMID:17971868 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BAX mRNA
Pilocarpine results in increased expression of BAX mRNA; Pilocarpine results in increased expression of BAX protein
CTD PMID:14754538 PMID:17971868 PMID:19429016 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein CTD PMID:22874420 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl10 BCL10, immune signaling adaptor decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BCL10 mRNA
Pilocarpine results in increased expression of BCL10 mRNA
CTD PMID:17971868 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Pilocarpine results in decreased expression of BCL2 protein CTD PMID:19429016 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression EXP Pilocarpine results in increased expression of BCL2A1 mRNA CTD PMID:17971868 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases response to substance ISO BDKRB1 protein mutant form results in decreased susceptibility to Pilocarpine CTD PMID:15196965 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 protein mutant form results in increased susceptibility to Pilocarpine CTD PMID:15196965 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of BDNF protein modified form
Pilocarpine results in increased expression of BDNF exon; Pilocarpine results in increased expression of BDNF mRNA; Pilocarpine results in increased expression of BDNF mRNA alternative form; Pilocarpine results in increased expression of BDNF protein
Pilocarpine results in decreased expression of BDNF protein
1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 1 alpha,24-dihydroxyvitamin D3 promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA alternative form]; [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA; Pilocarpine results in increased expression of and results in increased localization of BDNF protein; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
CTD PMID:8405262 PMID:8635431 PMID:8821376 PMID:9015327 PMID:9073163 More... NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]; Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]
Pilocarpine results in increased expression of BECN1 mRNA; Pilocarpine results in increased expression of BECN1 protein
CTD PMID:17971868 PMID:19138675 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BMP4 mRNA
Pilocarpine results in increased expression of BMP4 mRNA
CTD PMID:17971868 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression EXP Pilocarpine results in increased expression of BNIP1 mRNA CTD PMID:17971868 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Pilocarpine results in increased expression of BNIP3 mRNA CTD PMID:17971868 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1A protein
Pilocarpine results in increased expression of CACNA1A protein
CTD PMID:17265461 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1B mRNA; Pilocarpine results in decreased expression of CACNA1B protein
Pilocarpine results in increased expression of CACNA1B protein
CTD PMID:19811616 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1C protein
Pilocarpine results in increased expression of CACNA1C protein
CTD PMID:17265461 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1D protein
Pilocarpine results in increased expression of CACNA1D protein
CTD PMID:17265461 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Casp12 caspase 12 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
[Pilocarpine co-treated with Lithium] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Pilocarpine results in increased cleavage of and results in increased activity of CASP3 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Pilocarpine results in increased expression of CASP3 protein modified form
CTD PMID:12097334 PMID:18708038 PMID:18815271 PMID:19429016 PMID:19631748 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions EXP Pilocarpine results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:12097334 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp9 caspase 9 increases expression ISO Pilocarpine results in increased expression of CASP9 protein CTD PMID:18708038 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity
increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased activity of CAT protein
Pilocarpine results in increased expression of CAT protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]; Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
CTD PMID:15245787 PMID:15752349 PMID:16115668 PMID:17205390 PMID:17383094 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
decreases expression
EXP
ISO
Pilocarpine results in increased expression of CCL2 mRNA; Pilocarpine results in increased expression of CCL2 protein
Pilocarpine results in decreased expression of CCL2 protein
CTD PMID:15193289 PMID:17971868 PMID:19490431 PMID:20034406 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CCL3 protein
Pilocarpine results in increased expression of CCL3 mRNA
CTD PMID:19490431 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 decreases expression ISO Pilocarpine results in decreased expression of CCR10 mRNA; Pilocarpine results in decreased expression of CCR10 protein CTD PMID:17181556 NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
decreases expression
EXP
ISO
Pilocarpine results in increased expression of CCR2 protein
Pilocarpine results in decreased expression of CCR2 mRNA; Pilocarpine results in decreased expression of CCR2 protein
CTD PMID:19490431 PMID:20034406 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO Pilocarpine results in decreased expression of CCR3 mRNA; Pilocarpine results in decreased expression of CCR3 protein CTD PMID:19490431 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO Pilocarpine results in decreased expression of CCR7 mRNA; Pilocarpine results in decreased expression of CCR7 protein CTD PMID:17181556 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO Pilocarpine results in decreased expression of CCR8 mRNA; Pilocarpine results in decreased expression of CCR8 protein CTD PMID:17181556 NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 decreases expression ISO Pilocarpine results in decreased expression of CCR9 mRNA; Pilocarpine results in decreased expression of CCR9 protein CTD PMID:17181556 NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
EXP Pilocarpine results in increased expression of CD40 protein
rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]
CTD PMID:18455351 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Pilocarpine results in increased expression of CD44 protein CTD PMID:15191797 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CDH1 protein
Pilocarpine results in increased expression of CDH1 protein
CTD PMID:12387456 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Pilocarpine results in increased expression of CDH2 mRNA; Pilocarpine results in increased expression of CDH2 protein CTD PMID:12125071 PMID:12387456 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Pilocarpine results in increased expression of CDK1 mRNA CTD PMID:14656328 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Pilocarpine results in increased expression of CDK2 mRNA CTD PMID:17971868 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Pilocarpine results in increased expression of CDKN1B mRNA CTD PMID:17971868 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CDKN2A mRNA
Pilocarpine results in increased expression of CDKN2A mRNA
CTD PMID:17971868 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of CEBPA mRNA] CTD PMID:32494933 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions
decreases expression
EXP Pilocarpine results in decreased activity of CHAT protein
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein
Pilocarpine results in decreased expression of CHAT protein
CTD PMID:19669875 PMID:19932735 PMID:19941057 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
increases expression
affects binding
decreases expression
increases activity
affects response to substance
ISO
EXP
[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]
Pilocarpine results in increased expression of CHRM1 protein
CHRM1 protein binds to Pilocarpine
Pilocarpine results in decreased expression of CHRM1 protein
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
CHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]
CHRM1 protein affects the susceptibility to Pilocarpine
CTD PMID:9224827 PMID:11527950 PMID:12713643 PMID:14559291 PMID:15967574 More... NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression
increases expression
multiple interactions
affects binding
EXP
ISO
Pilocarpine results in decreased expression of CHRM2 protein
Pilocarpine results in increased expression of CHRM2 protein
eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]
CHRM2 protein binds to Pilocarpine
Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD PMID:9224827 PMID:14559291 PMID:32234387 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
increases expression
affects binding
ISO brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
Pilocarpine results in increased expression of CHRM3 protein
CHRM3 protein binds to Pilocarpine
CTD PMID:9224827 PMID:32234387 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
increases expression
affects binding
EXP
ISO
Pilocarpine binds to and results in increased activity of CHRM4 protein
Pilocarpine results in increased expression of CHRM4 protein
CHRM4 protein binds to Pilocarpine
brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; eburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]
CTD PMID:9224827 PMID:9920179 PMID:32234387 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 increases expression ISO Pilocarpine results in increased expression of CHRM5 protein CTD PMID:32234387 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
JBrowse link
G Cib1 calcium and integrin binding 1 increases expression EXP Pilocarpine results in increased expression of CIB1 mRNA CTD PMID:17971868 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Clcn2 chloride voltage-gated channel 2 affects expression EXP Pilocarpine affects the expression of CLCN2 protein CTD PMID:16930566 NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657
JBrowse link
G Cnn3 calponin 3 increases expression EXP Pilocarpine results in increased expression of CNN3 protein CTD PMID:14620880 NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Pilocarpine results in decreased expression of CNR1 protein CTD PMID:19368833 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Pilocarpine results in increased expression of CNTF mRNA CTD PMID:10506506 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CSF2 mRNA
Pilocarpine results in increased expression of CSF2 mRNA
CTD PMID:17971868 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression EXP Pilocarpine results in increased expression of CSF2RB mRNA CTD PMID:17166730 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Csn2 casein beta decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CSN2 mRNA
Pilocarpine results in increased expression of CSN2 mRNA
CTD PMID:17971868 NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
JBrowse link
G Ctf1 cardiotrophin 1 increases expression EXP Pilocarpine results in increased expression of CTF1 mRNA CTD PMID:10506506 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Pilocarpine results in increased expression of CTNNB1 protein CTD PMID:12387456 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D increases expression EXP Pilocarpine results in increased expression of CTSD mRNA CTD PMID:17971868 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Pilocarpine results in increased expression of CYP11A1 protein CTD PMID:19125849 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Dap3 death associated protein 3 increases expression EXP Pilocarpine results in increased expression of DAP3 mRNA CTD PMID:17971868 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461
JBrowse link
G Dclre1a DNA cross-link repair 1A increases expression EXP Pilocarpine results in increased expression of DCLRE1A mRNA CTD PMID:17971868 NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Pilocarpine results in increased expression of DDIT3 mRNA CTD PMID:17971868 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dmd dystrophin decreases expression EXP Pilocarpine results in decreased expression of DMD protein CTD PMID:20886625 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Pilocarpine results in increased expression of DPYSL2 protein CTD PMID:17366478 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression
multiple interactions
increases response to substance
EXP
ISO
Pilocarpine results in increased expression of DRD1 mRNA
Pilocarpine results in decreased expression of DRD1 protein
Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]
DRD1 protein results in increased susceptibility to Pilocarpine
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine; [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine
CTD PMID:1365435 PMID:7906944 PMID:14656328 PMID:15876489 PMID:16137708 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases expression
decreases response to substance
decreases activity
EXP
ISO
[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]
Pilocarpine results in decreased expression of DRD2 protein
DRD2 protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased activity of DRD2 protein
CTD PMID:1365435 PMID:11860278 PMID:14559291 PMID:15140183 PMID:15876489 More... NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Efna3 ephrin A3 decreases expression EXP Pilocarpine results in decreased expression of EFNA3 mRNA CTD PMID:18772502 NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP Pilocarpine results in decreased expression of EGFR mRNA CTD PMID:17971868 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of EGR1 mRNA
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]
CTD PMID:7968354 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 multiple interactions
increases expression
EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr3 early growth response 3 multiple interactions
increases expression
EXP Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
Pilocarpine results in increased expression of EGR3 mRNA; Pilocarpine results in increased expression of EGR3 protein
CTD PMID:16091474 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression EXP Pilocarpine results in decreased expression of EI24 mRNA CTD PMID:17971868 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein CTD PMID:16492139 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases activity
ISO Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]
Pilocarpine results in increased activity of EIF2AK3 protein
CTD PMID:16492139 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]
Pilocarpine results in increased phosphorylation of EIF2S1 protein
CTD PMID:15003282 PMID:16492139 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Epha5 EPH receptor A5 decreases expression EXP Pilocarpine results in decreased expression of EPHA5 mRNA; Pilocarpine results in decreased expression of EPHA5 protein CTD PMID:18772502 NCBI chr14:23,653,393...24,020,135
Ensembl chr14:23,653,393...24,017,317
JBrowse link
G Epo erythropoietin increases expression EXP Pilocarpine results in increased expression of EPO mRNA CTD PMID:17166730 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor increases expression EXP Pilocarpine results in increased expression of EPOR mRNA CTD PMID:17166730 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression EXP Pilocarpine results in increased expression of ERCC1 mRNA CTD PMID:17971868 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression EXP Pilocarpine results in increased expression of ERCC3 mRNA CTD PMID:17971868 NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329
JBrowse link
G Ezr ezrin increases expression EXP Pilocarpine results in increased expression of EZR protein CTD PMID:17366478 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F2 coagulation factor II increases activity ISO Pilocarpine results in increased activity of F2 protein CTD PMID:30515700 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein] CTD PMID:21087489 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression EXP Pilocarpine results in increased expression of FGF5 mRNA CTD PMID:8167846 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression
EXP [Pilocarpine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS protein; [Pilocarpine co-treated with Lithium] results in increased expression of FOS protein; [Pilocarpine co-treated with SCH 23390] results in increased expression of FOS protein; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of FOS mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Pilocarpine results in decreased expression of FOS mRNA
Pilocarpine results in increased expression of FOS mRNA; Pilocarpine results in increased expression of FOS protein
CTD PMID:7713058 PMID:7968354 PMID:7984056 PMID:8281324 PMID:8511714 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Pilocarpine results in increased expression of FOSB protein CTD PMID:16391389 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Pilocarpine results in decreased expression of FSHB protein CTD PMID:9761326 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases expression
EXP bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA] CTD PMID:20821261 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of GABRA4 protein
Pilocarpine results in increased expression of GABRA4 mRNA
Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
CTD PMID:15456836 PMID:16091474 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
decreases expression
EXP bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA] CTD PMID:20821261 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta multiple interactions
decreases expression
EXP
ISO
bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]
Pilocarpine results in decreased expression of GABRD protein
CTD PMID:15456836 PMID:20821261 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Pilocarpine results in increased expression of GABRG2 protein CTD PMID:15456836 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Pilocarpine results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 affects expression
increases expression
decreases expression
EXP Pilocarpine affects the expression of GAD2 protein
Pilocarpine results in increased expression of GAD2 mRNA; Pilocarpine results in increased expression of GAD2 protein
Pilocarpine results in decreased expression of GAD2 protein
CTD PMID:12183020 PMID:15857427 PMID:15987249 PMID:16797850 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gap43 growth associated protein 43 decreases expression
increases expression
ISO
EXP
Pilocarpine results in decreased expression of GAP43 protein
Pilocarpine results in increased expression of GAP43 mRNA
CTD PMID:15191797 PMID:16134595 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
multiple interactions
EXP Pilocarpine results in increased expression of GDNF mRNA
[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein
CTD PMID:7854063 PMID:12914250 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression
decreases expression
EXP 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]]
Pilocarpine results in decreased expression of GFAP protein
CTD PMID:25101675 PMID:30542433 PMID:31018114 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
affects localization
EXP Pilocarpine results in increased expression of GJA1 protein
Pilocarpine affects the localization of GJA1 protein
CTD PMID:21177194 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA] CTD PMID:32494933 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Pilocarpine results in decreased expression of GLUL protein CTD PMID:25101675 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO Pilocarpine results in increased secretion of GPT protein CTD PMID:32234387 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of GRIA1 mRNA
Pilocarpine results in increased expression of GRIA1 protein
CTD PMID:7529610 PMID:15857427 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
decreases expression
increases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA
Pilocarpine results in decreased expression of GRIA2 mRNA
Pilocarpine results in increased expression of GRIA2 3' UTR alternative form; Pilocarpine results in increased expression of GRIA2 protein
CTD PMID:15857427 PMID:16819974 PMID:19222700 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions
increases expression
decreases expression
EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA
Pilocarpine results in increased expression of GRIA3 mRNA; Pilocarpine results in increased expression of GRIA3 protein
Pilocarpine results in decreased expression of GRIA3 mRNA
CTD PMID:7529610 PMID:15857427 PMID:16819974 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions EXP [Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine CTD PMID:12080343 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA CTD PMID:16819974 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA CTD PMID:16819974 NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
decreases expression
EXP Plant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA] CTD PMID:18086456 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
increases expression
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]
Pilocarpine results in decreased expression of GRIN2A protein
CTD PMID:15857427 PMID:16600505 PMID:22824136 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression
increases expression
multiple interactions
EXP Pilocarpine results in decreased expression of GRIN2B protein
Pilocarpine results in increased expression of GRIN2B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]
CTD PMID:15857427 PMID:16600505 PMID:22824136 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression
multiple interactions
increases expression
EXP Pilocarpine results in decreased expression of GRM1 protein
[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of GRM1 mRNA
Pilocarpine results in increased expression of GRM1 protein
CTD PMID:11463519 PMID:32494933 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm2 glutamate metabotropic receptor 2 decreases expression EXP Pilocarpine results in decreased expression of GRM2 mRNA; Pilocarpine results in decreased expression of GRM2 protein CTD PMID:16793029 PMID:18585369 PMID:18804094 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Grm3 glutamate metabotropic receptor 3 decreases expression EXP Pilocarpine results in decreased expression of GRM3 mRNA; Pilocarpine results in decreased expression of GRM3 protein CTD PMID:16793029 PMID:18585369 PMID:18804094 NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
decreases expression
EXP [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased expression of GRM5 mRNA; Pilocarpine results in decreased expression of GRM5 protein
CTD PMID:15009663 PMID:17634364 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Grm8 glutamate metabotropic receptor 8 increases expression
decreases expression
EXP Pilocarpine results in increased expression of GRM8 protein
Pilocarpine results in decreased expression of GRM8
CTD PMID:11226630 PMID:12539201 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions
decreases expression
EXP [Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA
Pilocarpine results in decreased expression of HCN1 protein
CTD PMID:12890777 PMID:21905079 NCBI chr 2:49,495,771...49,899,702
Ensembl chr 2:49,495,771...49,899,774
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression EXP Pilocarpine results in increased expression of HIF1A mRNA CTD PMID:17166730 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk2 hexokinase 2 increases expression EXP Pilocarpine results in increased expression of HK2 mRNA CTD PMID:17971868 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
Pilocarpine results in increased expression of HMOX1 protein
Pilocarpine results in increased expression of HMOX1 mRNA
CTD PMID:20971094 PMID:25715797 PMID:32234387 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hoxb1 homeo box B1 decreases expression EXP Pilocarpine results in decreased expression of HOXB1 mRNA CTD PMID:17971868 NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836
JBrowse link
G Hrk harakiri, BCL2 interacting protein decreases expression EXP Pilocarpine results in decreased expression of HRK mRNA CTD PMID:17971868 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsbp1 heat shock factor binding protein 1 decreases expression EXP Pilocarpine results in decreased expression of HSBP1 mRNA CTD PMID:17971868 NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein; Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein] CTD PMID:21429313 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Pilocarpine results in increased expression of HSPB1 mRNA; Pilocarpine results in increased expression of HSPB1 protein CTD PMID:17971868 PMID:20971094 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine; [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine CTD PMID:2533336 PMID:15140183 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP [cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine CTD PMID:2533336 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression
decreases expression
EXP Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]
Pilocarpine results in increased expression of HTR2C mRNA; Pilocarpine results in increased expression of HTR2C protein
Pilocarpine results in decreased expression of HTR2C mRNA; Pilocarpine results in decreased expression of HTR2C protein
CTD PMID:19439326 PMID:19700373 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP 1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IFNG protein] CTD PMID:15781040 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression EXP Pilocarpine results in increased expression of IGFBP3 mRNA CTD PMID:17971868 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
increases expression
EXP 1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IL10 protein]
Pilocarpine results in increased expression of IL10 protein
CTD PMID:15781040 PMID:17872965 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B increases expression ISO Pilocarpine results in increased expression of IL12B mRNA CTD PMID:15193289 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO
EXP
[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
Pilocarpine results in increased expression of IL1B mRNA; Pilocarpine results in increased expression of IL1B protein
Pilocarpine results in decreased expression of IL1B mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]
CTD PMID:19010416 PMID:19055492 PMID:19951488 PMID:21087489 PMID:23211629 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression EXP Pilocarpine results in decreased expression of IL2 mRNA CTD PMID:17971868 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4r interleukin 4 receptor increases expression EXP Pilocarpine results in increased expression of IL4R mRNA CTD PMID:17971868 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of IL6 mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 protein
CTD PMID:19055492 PMID:31018114 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ilk integrin-linked kinase decreases activity ISO Pilocarpine results in decreased activity of ILK protein CTD PMID:19631748 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Impa1 inositol monophosphatase 1 increases response to substance
decreases response to substance
affects response to substance
ISO IMPA1 gene mutant form results in increased susceptibility to Pilocarpine
IMPA1 protein results in decreased susceptibility to Pilocarpine
IMPA1 protein affects the susceptibility to Pilocarpine
CTD PMID:17460611 PMID:17602744 PMID:19754464 NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression EXP Pilocarpine results in increased expression of ITGA1 protein CTD PMID:12851778 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Itga2 integrin subunit alpha 2 increases expression EXP Pilocarpine results in increased expression of ITGA2 protein CTD PMID:12851778 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression EXP Pilocarpine results in increased expression of ITGA4 protein CTD PMID:12851778 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression EXP Pilocarpine results in increased expression of ITGA5 protein CTD PMID:12851778 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression
increases expression
ISO
EXP
Pilocarpine results in decreased expression of ITGB1 protein
Pilocarpine results in increased expression of ITGB1 protein
CTD PMID:12851778 PMID:19631748 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression EXP Pilocarpine results in increased expression of ITGB3 protein CTD PMID:12851778 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itgb4 integrin subunit beta 4 increases expression EXP Pilocarpine results in increased expression of ITGB4 protein CTD PMID:12851778 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of JUN protein; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056 PMID:17971868 PMID:19430551 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 PMID:7984056 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 decreases expression EXP Pilocarpine results in decreased expression of KCNC4 mRNA; Pilocarpine results in decreased expression of KCNC4 protein CTD PMID:20971086 NCBI chr 2:195,063,967...195,099,233
Ensembl chr 2:195,071,769...195,099,233
JBrowse link
G Kcnk5 potassium two pore domain channel subfamily K member 5 increases expression
decreases expression
EXP Pilocarpine results in increased expression of KCNK5 protein
Pilocarpine results in decreased expression of KCNK5 protein
CTD PMID:19220408 NCBI chr15:4,122,442...4,164,718
Ensembl chr15:4,122,442...4,164,718
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 decreases expression EXP Pilocarpine results in decreased expression of KCNMA1 mRNA CTD PMID:18695509 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases expression EXP Pilocarpine results in decreased expression of KCNN1 protein CTD PMID:20553876 NCBI chr16:18,574,858...18,597,780
Ensembl chr16:18,585,992...18,597,482
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression EXP Pilocarpine results in decreased expression of KCNN2 mRNA; Pilocarpine results in decreased expression of KCNN2 protein CTD PMID:20553876 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
JBrowse link
G Kcnn3 potassium calcium-activated channel subfamily N member 3 decreases expression EXP Pilocarpine results in decreased expression of KCNN3 mRNA; Pilocarpine results in decreased expression of KCNN3 protein CTD PMID:20553876 NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Pilocarpine results in increased expression of LAMP2 protein]
Pilocarpine results in increased expression of LAMP2 mRNA; Pilocarpine results in increased expression of LAMP2 protein
CTD PMID:19272430 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Pilocarpine results in decreased expression of LHB protein CTD PMID:9761326 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression EXP Pilocarpine results in increased expression of LIF mRNA CTD PMID:10506506 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Pilocarpine results in increased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12091480 PMID:17360923 PMID:18988310 PMID:19402951 PMID:22824136 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
Pilocarpine results in increased phosphorylation of MAPK3 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
CTD PMID:12091480 PMID:17360923 PMID:18988310 PMID:19402951 PMID:22824136 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; W 7 inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mef2c myocyte enhancer factor 2C increases expression EXP Pilocarpine results in increased expression of MEF2C mRNA CTD PMID:18949272 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Pilocarpine results in increased expression of MGMT mRNA CTD PMID:17971868 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mir200c microRNA 200c multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] results in increased expression of MIR200C mRNA CTD PMID:31018114 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
ISO Pilocarpine results in increased activity of MMP9 protein
Pilocarpine results in increased expression of MMP9 protein
CTD PMID:19631748 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease increases expression EXP Pilocarpine results in increased expression of MRE11A mRNA CTD PMID:17971868 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Msn moesin increases expression EXP Pilocarpine results in increased expression of MSN mRNA CTD PMID:14656328 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
EXP dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein] CTD PMID:23211629 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression EXP Pilocarpine results in increased expression of MYD88 mRNA CTD PMID:17971868 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression EXP Pilocarpine results in decreased expression of NAIP2 mRNA CTD PMID:17971868 NCBI chr 2:31,507,423...31,559,098 JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 decreases expression ISO Pilocarpine results in decreased expression of NFAT5 mRNA CTD PMID:21219332 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Pilocarpine results in increased expression of NFE2L2 protein CTD PMID:32234387 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Pilocarpine results in increased expression of NFKBIA mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]
CTD PMID:15193289 PMID:23211629 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Ketamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA] CTD PMID:8635431 PMID:8821376 PMID:15183516 PMID:17971868 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor increases expression
multiple interactions
increases response to substance
ISO
EXP
Pilocarpine results in increased expression of NGFR protein
Pilocarpine results in increased expression of NGFR mRNA; Pilocarpine results in increased expression of NGFR protein
PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]
NGFR protein results in increased susceptibility to Pilocarpine
CTD PMID:10436046 PMID:12097334 PMID:18815271 PMID:21084616 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS1 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein] CTD PMID:18672383 PMID:20149694 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS2 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]
Pilocarpine results in increased expression of NOS2 mRNA; Pilocarpine results in increased expression of NOS2 protein
CTD PMID:18672383 PMID:20149694 PMID:23211629 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nova1 NOVA alternative splicing regulator 1 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of NOVA1 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]
CTD PMID:20470870 NCBI chr 6:63,780,105...63,905,950
Ensembl chr 6:63,783,489...63,906,289
JBrowse link
G Nova2 NOVA alternative splicing regulator 2 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of NOVA2 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]
CTD PMID:20470870 NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021
JBrowse link
G Nptx2 neuronal pentraxin 2 increases expression EXP Pilocarpine results in increased expression of NPTX2 mRNA CTD PMID:14656328 NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
JBrowse link
G Npy neuropeptide Y decreases response to substance
increases expression
ISO
EXP
NPY protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in increased expression of NPY protein
CTD PMID:12231234 PMID:12821374 PMID:15451008 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Pilocarpine results in increased expression of NQO1 protein CTD PMID:32234387 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 protein] CTD PMID:32494933 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of NTF3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]
CTD PMID:8635431 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases expression
EXP Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] CTD PMID:8635431 PMID:8821376 PMID:15183516 PMID:19686240 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of NTRK3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]
CTD PMID:8635431 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Pilocarpine results in increased expression of ODC1 mRNA CTD PMID:17971868 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression EXP Pilocarpine results in decreased expression of OGG1 mRNA; Pilocarpine results in decreased expression of OGG1 protein CTD PMID:20206232 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 protein results in decreased susceptibility to Pilocarpine CTD PMID:7894264 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 decreases expression EXP Pilocarpine results in decreased expression of OPRM1 protein CTD PMID:17919468 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Osm oncostatin M increases expression EXP Pilocarpine results in increased expression of OSM mRNA CTD PMID:10506506 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression EXP Pilocarpine results in increased expression of P2RX7 protein CTD PMID:19138473 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression
multiple interactions
EXP Pilocarpine affects the expression of PARP1 protein
3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; [Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]
CTD PMID:25101675 PMID:31396050 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Pilocarpine results in increased expression of PCNA mRNA CTD PMID:17971868 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression EXP Pilocarpine results in increased expression of PCSK1 mRNA CTD PMID:9015327 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pdxk pyridoxal kinase increases expression EXP Pilocarpine results in increased expression of PDXK protein CTD PMID:19356691 NCBI chr20:10,210,393...10,231,937
Ensembl chr20:10,210,289...10,232,110
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 multiple interactions EXP [Pilocarpine co-treated with Lithium Chloride co-treated with 3-chloroacetylindole] results in decreased phosphorylation of PEA15 protein; [Pilocarpine co-treated with Lithium Chloride] results in decreased phosphorylation of PEA15 protein CTD PMID:31396050 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression ISO Pilocarpine results in increased expression of PLCB4 protein CTD PMID:18774262 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase increases expression EXP Pilocarpine results in increased expression of PNKP mRNA CTD PMID:17971868 NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920
JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase increases expression EXP Pilocarpine results in increased expression of PNPO protein CTD PMID:19356691 NCBI chr10:81,924,584...81,930,844
Ensembl chr10:81,924,569...81,930,871
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression EXP Pilocarpine results in increased expression of POLG mRNA; Pilocarpine results in increased expression of POLG protein CTD PMID:20446108 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Pilocarpine results in increased expression of PPP1R15A protein CTD PMID:16492139 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Pilocarpine results in decreased expression of PPP3R1 mRNA CTD PMID:14656328 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Prkcb protein kinase C, beta increases expression
decreases expression
ISO
EXP
Pilocarpine results in increased expression of PRKCB protein
Pilocarpine results in decreased expression of PRKCB mRNA
CTD PMID:15058486 PMID:17971868 PMID:18774262 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta increases expression EXP Pilocarpine results in increased expression of PRKCD protein CTD PMID:15058486 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkcg protein kinase C, gamma increases expression ISO
EXP
Pilocarpine results in increased expression of PRKCG protein CTD PMID:15058486 PMID:18774262 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Prkch protein kinase C, eta increases expression EXP Pilocarpine results in increased expression of PRKCH protein CTD PMID:15058486 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Pilocarpine results in increased expression of PRKCZ protein CTD PMID:15058486 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein] CTD PMID:21084616 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Pilocarpine results in increased expression of PTGES mRNA CTD PMID:15193289 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of PTGS2 mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]
Pilocarpine results in increased expression of PTGS2 mRNA; Pilocarpine results in increased expression of PTGS2 protein
CTD PMID:15193289 PMID:23211629 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein
Pilocarpine results in increased phosphorylation of PTK2 protein
CTD PMID:10537051 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions
decreases response to substance
ISO PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PTPN5 protein mutant form results in decreased susceptibility to Pilocarpine
CTD PMID:17360923 PMID:21204826 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 affects expression EXP Pilocarpine affects the expression of PTPRZ1 protein CTD PMID:10582521 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
JBrowse link
G Pvalb parvalbumin decreases expression EXP Pilocarpine results in decreased expression of PVALB protein CTD PMID:12183020 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Qdpr quinoid dihydropteridine reductase increases expression EXP Pilocarpine results in increased expression of QDPR protein CTD PMID:17366478 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression
decreases expression
EXP Pilocarpine results in increased expression of RAD23A mRNA
Pilocarpine results in decreased expression of RAD23A mRNA
CTD PMID:17971868 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein increases expression EXP Pilocarpine results in increased expression of RAD23B mRNA CTD PMID:17971868 NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK mRNA; [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK protein CTD PMID:31018114 NCBI chr 5:58,102,915...58,169,513
Ensembl chr 5:58,102,981...58,169,502
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; [Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein] CTD PMID:31396050 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ret ret proto-oncogene multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of RET protein CTD PMID:12914250 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Rpl32 ribosomal protein L32 multiple interactions ISO Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein] CTD PMID:16492139 NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
EXP dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein] CTD PMID:23211629 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Pilocarpine results in increased expression of S100B protein CTD PMID:18226170 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases response to substance ISO SCN2B protein results in decreased susceptibility to Pilocarpine CTD PMID:12481039 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 increases expression EXP Pilocarpine results in increased expression of SCN8A mRNA; Pilocarpine results in increased expression of SCN8A protein CTD PMID:19306853 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
EXP dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Niacinamide inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein] CTD PMID:23211629 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO
EXP
Pilocarpine results in increased expression of SLC12A2 mRNA; Pilocarpine results in increased expression of SLC12A2 protein CTD PMID:18550034 PMID:19674083 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc12a5 solute carrier family 12 member 5 decreases expression
multiple interactions
increases degradation
ISO
EXP
Pilocarpine results in decreased expression of SLC12A5 mRNA; Pilocarpine results in decreased expression of SLC12A5 protein
Pilocarpine results in increased phosphorylation of and affects the localization of SLC12A5 protein
Pilocarpine results in increased degradation of SLC12A5 protein
CTD PMID:18094240 PMID:18550034 PMID:19674083 PMID:20600929 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression EXP Pilocarpine results in increased expression of SLC17A7 protein CTD PMID:17503488 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP Pilocarpine results in increased expression of SLC1A1 mRNA; Pilocarpine results in increased expression of SLC1A1 protein CTD PMID:11906504 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pilocarpine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc32a1 solute carrier family 32 member 1 increases expression EXP Pilocarpine results in increased expression of SLC32A1 mRNA; Pilocarpine results in increased expression of SLC32A1 protein CTD PMID:17503488 NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844
JBrowse link
G Slc5a3 solute carrier family 5 member 3 increases response to substance
increases expression
affects response to substance
ISO SLC5A3 gene mutant form results in increased susceptibility to Pilocarpine
Pilocarpine results in increased expression of SLC5A3 mRNA
SLC5A3 protein affects the susceptibility to Pilocarpine
CTD PMID:17602744 PMID:19754464 PMID:21219332 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases expression EXP
ISO
Pilocarpine results in decreased expression of SLC6A1 protein
Pilocarpine results in decreased expression of SLC6A1 mRNA
CTD PMID:12183020 PMID:21219332 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293
JBrowse link
G Slc6a11 solute carrier family 6 member 11 decreases expression ISO Pilocarpine results in decreased expression of SLC6A11 mRNA CTD PMID:21219332 NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443
JBrowse link
G Slc6a12 solute carrier family 6 member 12 decreases expression
increases expression
ISO Pilocarpine results in decreased expression of SLC6A12 mRNA
Pilocarpine results in increased expression of SLC6A12 mRNA
CTD PMID:21219332 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression ISO Pilocarpine results in increased expression of SLC6A6 mRNA CTD PMID:21219332 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP Pilocarpine results in decreased expression of SLCO1A4 protein CTD PMID:19570321 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slit2 slit guidance ligand 2 increases expression
decreases expression
EXP Pilocarpine results in increased expression of SLIT2 protein
Pilocarpine results in decreased expression of SLIT2 protein
CTD PMID:20153733 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression EXP Pilocarpine results in increased expression of SMC3 mRNA CTD PMID:17971868 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Snta1 syntrophin, alpha 1 decreases expression EXP Pilocarpine results in decreased expression of SNTA1 protein CTD PMID:20886625 NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Pilocarpine results in increased expression of SOD2 protein CTD PMID:20446108 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sparcl1 SPARC like 1 affects localization
decreases expression
EXP Pilocarpine affects the localization of SPARCL1 protein
Pilocarpine results in decreased expression of SPARCL1 protein
CTD PMID:18488994 PMID:18808451 NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of SRC protein CTD PMID:16600505 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Sstr1 somatostatin receptor 1 increases expression EXP Pilocarpine results in increased expression of SSTR1 protein CTD PMID:18951627 NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression EXP Pilocarpine results in increased expression of SSTR2 protein CTD PMID:18951627 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
JBrowse link
G Sstr3 somatostatin receptor 3 decreases expression EXP Pilocarpine results in decreased expression of SSTR3 protein CTD PMID:18951627 NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
JBrowse link
G Sstr4 somatostatin receptor 4 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of SSTR4 protein
Pilocarpine results in increased expression of SSTR4 protein
CTD PMID:18951627 NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689
JBrowse link
G Sstr5 somatostatin receptor 5 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of SSTR5 protein
Pilocarpine results in increased expression of SSTR5 protein
CTD PMID:18951627 NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946
JBrowse link
G Star steroidogenic acute regulatory protein increases localization EXP Pilocarpine results in increased localization of STAR protein CTD PMID:20609383 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stard6 StAR-related lipid transfer domain containing 6 increases localization
increases expression
EXP Pilocarpine results in increased localization of STARD6 protein
Pilocarpine results in increased expression of STARD6 protein
CTD PMID:19434006 PMID:20609383 NCBI chr18:64,089,618...64,118,528
Ensembl chr18:64,089,471...64,107,099
JBrowse link
G Syp synaptophysin increases expression EXP Pilocarpine results in increased expression of SYP protein CTD PMID:16134595 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 protein modified form; Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] CTD PMID:11074153 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tdg thymine-DNA glycosylase increases expression EXP Pilocarpine results in increased expression of TDG mRNA CTD PMID:17971868 NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Pilocarpine results in increased expression of TFAM mRNA; Pilocarpine results in increased expression of TFAM protein CTD PMID:20446108 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Thrb thyroid hormone receptor beta increases expression EXP Pilocarpine results in increased expression of THRB mRNA CTD PMID:14656328 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Pilocarpine results in increased expression of TIMP2 mRNA CTD PMID:14656328 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Pilocarpine results in decreased expression of TJP1 protein CTD PMID:17533168 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Pilocarpine results in increased expression of TLR2 mRNA CTD PMID:15193289 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of TLR4 mRNA] CTD PMID:32494933 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnc tenascin C increases expression EXP Pilocarpine results in increased expression of TNC mRNA CTD PMID:14656328 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of TNF mRNA
Pilocarpine results in increased expression of TNF protein
Pilocarpine results in decreased expression of TNF mRNA; Pilocarpine results in decreased expression of TNF protein
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF protein; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of TNF protein]
CTD PMID:15193289 PMID:17872965 PMID:18455351 PMID:19055492 PMID:31018114 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Pilocarpine results in increased expression of TNFRSF1A mRNA CTD PMID:17971868 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Pilocarpine results in decreased expression of TNFSF10 mRNA CTD PMID:17971868 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Pilocarpine results in decreased expression of TNFSF13 mRNA CTD PMID:17971868 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
JBrowse link
G Tnr tenascin R increases expression EXP Pilocarpine results in increased expression of TNR protein CTD PMID:15120744 NCBI chr13:71,751,714...72,172,731
Ensembl chr13:72,091,585...72,167,641
JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression EXP Pilocarpine results in increased expression of TREX1 mRNA CTD PMID:17971868 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
JBrowse link
G Trh thyrotropin releasing hormone increases expression EXP Pilocarpine results in increased expression of TRH mRNA CTD PMID:10443546 PMID:15781040 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases activity
decreases expression
EXP Pilocarpine results in decreased activity of TRHR protein
Pilocarpine results in decreased expression of TRHR protein
CTD PMID:10443546 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 increases expression EXP Pilocarpine results in increased expression of UBE2D3 mRNA CTD PMID:17971868 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression EXP Pilocarpine results in increased expression of UBE2I mRNA CTD PMID:17971868 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Vdr vitamin D receptor increases expression EXP Pilocarpine results in increased expression of VDR mRNA CTD PMID:18534255 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Pilocarpine results in increased expression of VEGFA protein CTD PMID:17533168 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP Pilocarpine results in increased expression of VGF mRNA CTD PMID:14656328 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases expression EXP Pilocarpine results in increased expression of XRCC1 mRNA CTD PMID:17971868 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression EXP Pilocarpine results in increased expression of XRCC3 mRNA CTD PMID:17971868 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
JBrowse link
G Zfp110 zinc finger protein 110 multiple interactions ISO ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein] CTD PMID:18815271 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      group 19741
        inorganic group 19271
          oxo group 18675
            organic oxo compound 18675
              carbonyl compound 18675
                carboxylic ester 15884
                  lactone 11242
                    gamma-lactone 6740
                      butan-4-olide 308
                        xi,xi-pilocarpine 303
                          isopilocarpine + 0
                          pilocarpine + 303
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic ester 15884
                                        lactone 11242
                                          gamma-lactone 6740
                                            butan-4-olide 308
                                              xi,xi-pilocarpine 303
                                                isopilocarpine + 0
                                                pilocarpine + 303
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