Bcl10 (BCL10, immune signaling adaptor) - Rat Genome Database

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Gene: Bcl10 (BCL10, immune signaling adaptor) Rattus norvegicus
Analyze
Symbol: Bcl10
Name: BCL10, immune signaling adaptor
RGD ID: 620544
Description: Predicted to enable several functions, including CARD domain binding activity; NF-kappaB binding activity; and enzyme binding activity. Predicted to contribute to kinase activator activity. Involved in positive regulation of apoptotic process. Part of protein-containing complex. Human ortholog(s) of this gene implicated in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor); PARTICIPATES IN nuclear factor kappa B signaling pathway; B cell receptor signaling pathway; T cell receptor signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; bcl-10; R-RCD1; RCD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82237,501,181 - 237,510,821 (+)NCBIGRCr8
mRatBN7.22234,840,880 - 234,850,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2234,840,858 - 234,850,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2242,633,160 - 242,642,800 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,523,460 - 240,533,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,390,779 - 235,400,419 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02251,805,392 - 251,814,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,805,392 - 251,814,957 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,330,540 - 270,340,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,116,880 - 244,126,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,103,619 - 244,113,130 (+)NCBI
Celera2226,822,923 - 226,832,565 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3-methylcholanthrene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Myrtucommulone A  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
nitrates  (EXP)
o-anisidine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP,ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IBA,ISO,ISS)
antifungal innate immune response  (ISO,ISS)
apoptotic process  (IEA)
B cell apoptotic process  (ISO)
cellular defense response  (ISO)
cellular response to lipopolysaccharide  (ISO,ISS)
cellular response to mechanical stimulus  (ISO)
fibroblast apoptotic process  (ISO)
immunoglobulin mediated immune response  (ISO)
innate immune response  (ISO,ISS)
lipopolysaccharide-mediated signaling pathway  (ISO,ISS)
negative regulation of mature B cell apoptotic process  (ISO,ISS)
neural tube closure  (ISO,ISS)
non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of apoptotic process  (IDA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
positive regulation of cytokine production  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway  (IBA,ISO,ISS)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO,ISS)
positive regulation of phosphorylation  (ISO,ISS)
positive regulation of protein ubiquitination  (ISO,ISS)
positive regulation of T cell activation  (ISO)
positive regulation of T cell receptor signaling pathway  (ISO,ISS)
programmed cell death  (ISO,ISS)
protein homooligomerization  (ISO,ISS)
regulation of apoptotic process  (IEA)
regulation of T cell receptor signaling pathway  (ISO)
response to food  (ISO,ISS)
response to fungus  (ISO)
response to lipopolysaccharide  (ISO)
T cell apoptotic process  (ISO)
T cell receptor signaling pathway  (ISO,ISS)
thymocyte apoptotic process  (ISO)
toll-like receptor signaling pathway  (ISO)

Cellular Component
CBM complex  (IBA,ISO,ISS)
cytoplasm  (ISO,ISS)
cytoplasmic microtubule  (ISO,ISS)
cytosol  (IBA,ISO,ISS)
immunological synapse  (ISO)
lysosome  (ISO,ISS)
membrane raft  (ISO)
nucleus  (ISO,ISS)
perinuclear region of cytoplasm  (ISO,ISS)
polkadots  (ISO)
protein-containing complex  (IDA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. Dong W, etal., J Biol Chem. 2006 Sep 8;281(36):26029-40. Epub 2006 Jul 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation. Guiet C and Vito P, J Cell Biol. 2000 Mar 20;148(6):1131-40.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Ruland J, etal., Cell 2001 Jan 12;104(1):33-42.
14. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. Yoneda T, etal., J Biol Chem 2000 Apr 14;275(15):11114-20.
Additional References at PubMed
PMID:10187771   PMID:10400625   PMID:11021819   PMID:11053425   PMID:11238466   PMID:11278692   PMID:11466612   PMID:11821383   PMID:12154360   PMID:12761501   PMID:12867038   PMID:14614861  
PMID:14695475   PMID:14724296   PMID:15082780   PMID:15125833   PMID:15207693   PMID:15489334   PMID:15878976   PMID:16127295   PMID:16280327   PMID:16395405   PMID:16495340   PMID:16862125  
PMID:17052756   PMID:17095757   PMID:18223652   PMID:19593445   PMID:22267217   PMID:23264731   PMID:25365219   PMID:25416956   PMID:28628108  


Genomics

Comparative Map Data
Bcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82237,501,181 - 237,510,821 (+)NCBIGRCr8
mRatBN7.22234,840,880 - 234,850,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2234,840,858 - 234,850,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2242,633,160 - 242,642,800 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,523,460 - 240,533,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,390,779 - 235,400,419 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02251,805,392 - 251,814,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,805,392 - 251,814,957 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,330,540 - 270,340,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,116,880 - 244,126,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,103,619 - 244,113,130 (+)NCBI
Celera2226,822,923 - 226,832,565 (+)NCBICelera
Cytogenetic Map2q44NCBI
BCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38185,265,776 - 85,276,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl185,265,776 - 85,276,632 (-)EnsemblGRCh38hg38GRCh38
GRCh37185,731,459 - 85,742,315 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,504,047 - 85,516,171 (-)NCBINCBI36Build 36hg18NCBI36
Build 34185,443,952 - 85,455,604NCBI
Celera183,975,888 - 83,987,016 (-)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef183,842,452 - 83,853,578 (-)NCBIHuRef
CHM1_1185,847,075 - 85,858,194 (-)NCBICHM1_1
T2T-CHM13v2.0185,106,896 - 85,118,200 (-)NCBIT2T-CHM13v2.0
Bcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393145,630,017 - 145,640,121 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3145,628,559 - 145,640,111 (+)EnsemblGRCm39 Ensembl
GRCm383145,924,262 - 145,934,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3145,922,804 - 145,934,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373145,587,342 - 145,597,247 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363145,861,764 - 145,871,669 (+)NCBIMGSCv36mm8
Celera3152,377,901 - 152,387,817 (+)NCBICelera
Cytogenetic Map3H2NCBI
cM Map371.03NCBI
Bcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554238,709,890 - 8,722,050 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554238,710,231 - 8,720,530 (+)NCBIChiLan1.0ChiLan1.0
BCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21141,656,198 - 141,666,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11140,811,692 - 140,822,264 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,823,388 - 117,834,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1186,679,646 - 86,690,841 (-)NCBIpanpan1.1PanPan1.1panPan2
BCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1662,712,937 - 62,723,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl662,712,971 - 62,722,368 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha665,361,863 - 65,372,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0663,252,846 - 63,263,759 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl663,252,838 - 63,263,752 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1662,780,042 - 62,790,957 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0662,750,582 - 62,761,263 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0663,258,042 - 63,268,727 (+)NCBIUU_Cfam_GSD_1.0
Bcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505895,863,804 - 95,871,302 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936608434,978 - 442,391 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936608434,740 - 442,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4130,645,216 - 130,657,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14130,645,427 - 130,653,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24143,237,003 - 143,244,894 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12048,073,489 - 48,084,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2048,073,800 - 48,085,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603369,724,709 - 69,736,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474212,210,360 - 12,221,759 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474212,210,333 - 12,222,533 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl10
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:516
Count of miRNA genes:248
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000019911
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat

Markers in Region
RH130053  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22234,850,298 - 234,850,457 (+)MAPPERmRatBN7.2
Rnor_6.02251,814,736 - 251,814,894NCBIRnor6.0
Rnor_5.02270,339,884 - 270,340,042UniSTSRnor5.0
RGSC_v3.42244,126,172 - 244,126,330UniSTSRGSC3.4
Celera2226,832,344 - 226,832,502UniSTS
Cytogenetic Map2q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019911   ⟹   ENSRNOP00000019911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2234,840,858 - 234,850,517 (+)Ensembl
Rnor_6.0 Ensembl2251,805,392 - 251,814,957 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096025   ⟹   ENSRNOP00000085446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2234,844,169 - 234,850,523 (+)Ensembl
RefSeq Acc Id: NM_031328   ⟹   NP_112618
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82237,501,181 - 237,510,821 (+)NCBI
mRatBN7.22234,840,880 - 234,850,520 (+)NCBI
Rnor_6.02251,805,392 - 251,814,957 (+)NCBI
Rnor_5.02270,330,540 - 270,340,105 (+)NCBI
RGSC_v3.42244,116,880 - 244,126,393 (+)RGD
Celera2226,822,923 - 226,832,565 (+)RGD
Sequence:
RefSeq Acc Id: NP_112618   ⟸   NM_031328
- UniProtKB: Q9QYN5 (UniProtKB/Swiss-Prot),   A6HWC4 (UniProtKB/TrEMBL),   A0A8I6A3W9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019911   ⟸   ENSRNOT00000019911
Ensembl Acc Id: ENSRNOP00000085446   ⟸   ENSRNOT00000096025
Protein Domains
CARD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYN5-F1-model_v2 AlphaFold Q9QYN5 1-233 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620544 AgrOrtholog
BioCyc Gene G2FUF-50916 BioCyc
Ensembl Genes ENSRNOG00000042389 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024853 UniProtKB/Swiss-Prot
  ENSRNOG00060000837 UniProtKB/Swiss-Prot
  ENSRNOG00065012766 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019911.7 UniProtKB/Swiss-Prot
  ENSRNOT00000096025.1 UniProtKB/TrEMBL
  ENSRNOT00055042844 UniProtKB/Swiss-Prot
  ENSRNOT00060001032 UniProtKB/Swiss-Prot
  ENSRNOT00065020833 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621919 IMAGE-MGC_LOAD
InterPro BCL10/E10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD_BCL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83477 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72408 IMAGE-MGC_LOAD
NCBI Gene 83477 ENTREZGENE
PANTHER B-CELL LYMPHOMA/LEUKEMIA 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR34920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcl10 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042389 RatGTEx
  ENSRNOG00055024853 RatGTEx
  ENSRNOG00060000837 RatGTEx
  ENSRNOG00065012766 RatGTEx
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A3W9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWC4 ENTREZGENE, UniProtKB/TrEMBL
  A6HWC5_RAT UniProtKB/TrEMBL
  BCL10_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Bcl10  BCL10, immune signaling adaptor  Bcl10  B-cell CLL/lymphoma 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bcl10  B-cell CLL/lymphoma 10  Bcl10  B-cell leukemia/lymphoma 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Bcl10  B-cell leukemia/lymphoma 10  Bcl10  B-cell CLL/lymphoma 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Bcl10  B-cell CLL/lymphoma 10      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bcl10  B-cell CLL/lymphoma 10      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease gene mutated in MALT lymphoma 631970
gene_mutations_overexpression overexpression reduces c-Jun N-terminal kinase activation and enhanced nuclear factor kappaB activation downstream of TRAF2 631970