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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gamma-lactone
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Accession:CHEBI:37581 term browser browse the term
Definition:A lactone having a five-membered lactone ring.
Synonyms:related_synonym: 1,4-Lactone;   1,4-lactones;   Formula=C4H3O2R3;   SMILES=O1C(C(C(C1=O)*)*)*;   a 1,4-lactone;   butyrolactones;   gamma-Laktone;   gamma-lactona;   gamma-lactonas;   gamma-lactones
 alt_id: CHEBI:13194;   CHEBI:18937;   CHEBI:22971;   CHEBI:541
 xref: PMID:18789684


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(+)-pilocarpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Pilocarpine results in increased expression of A2M mRNA CTD PMID:17971868 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression
increases expression
EXP Pilocarpine affects the expression of ABCB1A mRNA
Pilocarpine results in increased expression of ABCB1A mRNA; Pilocarpine results in increased expression of ABCB1A protein
CTD PMID:14706787, PMID:17437408, PMID:19055492 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects expression
increases expression
EXP Pilocarpine affects the expression of ABCB1B mRNA
Pilocarpine results in increased expression of ABCB1B mRNA; Pilocarpine results in increased expression of ABCB1B protein
CTD PMID:14706787, PMID:19055492, PMID:19570321 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects expression EXP Pilocarpine affects the expression of ABCC1 mRNA CTD PMID:19055492 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Pilocarpine results in increased expression of ABCC2 protein CTD PMID:16504477 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 affects expression EXP Pilocarpine affects the expression of ABCC5 mRNA CTD PMID:19055492 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE protein] CTD PMID:32494933 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
increases expression
decreases expression
EXP
ISO
Pilocarpine results in decreased activity of ACHE protein
garcinielliptone FC inhibits the reaction [Pilocarpine results in decreased activity of ACHE protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]; [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
Pilocarpine results in increased expression of ACHE mRNA alternative form; Pilocarpine results in increased expression of ACHE protein alternative form
CTD PMID:16481111, PMID:18242586, PMID:18333967, PMID:19669875, PMID:19932735, PMID:19941057, PMID:20730314, PMID:24911645 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actb actin, beta multiple interactions ISO Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein] CTD PMID:16492139 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP [2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine CTD PMID:11311893 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pilocarpine CTD PMID:19488739 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Pilocarpine CTD PMID:19125850 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Agrn agrin increases expression EXP Pilocarpine results in increased expression of AGRN protein CTD PMID:17971868 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A protein] CTD PMID:32494933 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of AGTR2 mRNA CTD PMID:32494933 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP Pilocarpine results in increased expression of AIF1 protein CTD PMID:18226170 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akap5 A-kinase anchoring protein 5 increases response to substance ISO AKAP5 protein mutant form results in increased susceptibility to Pilocarpine CTD PMID:18711127 NCBI chr 6:99,356,509...99,361,909
Ensembl chr 6:99,356,509...99,361,909
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Pilocarpine results in decreased phosphorylation of AKT1 protein
[Lithium Chloride co-treated with Pilocarpine] results in increased phosphorylation of AKT1 protein
CTD PMID:19429016, PMID:31018114 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase decreases expression
decreases activity
multiple interactions
EXP
ISO
Pilocarpine results in decreased expression of ALAD protein
Pilocarpine results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]
Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]; Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]
CTD PMID:19798568, PMID:20026167, PMID:20584200, PMID:25490531 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ank3 ankyrin 3 increases expression EXP Pilocarpine results in increased expression of ANK3 mRNA; Pilocarpine results in increased expression of ANK3 protein CTD PMID:19306853 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression
affects localization
decreases expression
EXP Pilocarpine results in increased expression of APEX1 mRNA
Pilocarpine affects the localization of APEX1 mRNA
Pilocarpine results in decreased expression of APEX1 protein
CTD PMID:17971868, PMID:20206232, PMID:20446108 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression EXP Pilocarpine results in decreased expression of APLP1 mRNA CTD PMID:19448684 NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750
JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Pilocarpine results in decreased expression of AQP4 protein CTD PMID:20886625 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Aqp5 aquaporin 5 multiple interactions
affects localization
ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Pilocarpine results in decreased expression of ASIC1 mRNA CTD PMID:11162239 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Pilocarpine results in decreased expression of ASIC2 mRNA alternative form CTD PMID:11162239 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions
increases expression
EXP [Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein
Pilocarpine results in increased expression of ATF2 mRNA
CTD PMID:17971868, PMID:19430551 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Pilocarpine results in increased expression of ATP2A2 protein CTD PMID:15288437 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression EXP Pilocarpine results in increased expression of ATRX mRNA CTD PMID:17971868 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BAX mRNA
Pilocarpine results in increased expression of BAX mRNA; Pilocarpine results in increased expression of BAX protein
CTD PMID:14754538, PMID:17971868, PMID:19429016 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein CTD PMID:22874420 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl10 BCL10, immune signaling adaptor decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BCL10 mRNA
Pilocarpine results in increased expression of BCL10 mRNA
CTD PMID:17971868 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Pilocarpine results in decreased expression of BCL2 protein CTD PMID:19429016 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression EXP Pilocarpine results in increased expression of BCL2A1 mRNA CTD PMID:17971868 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases response to substance ISO BDKRB1 protein mutant form results in decreased susceptibility to Pilocarpine CTD PMID:15196965 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 protein mutant form results in increased susceptibility to Pilocarpine CTD PMID:15196965 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of BDNF protein modified form
Pilocarpine results in increased expression of BDNF exon; Pilocarpine results in increased expression of BDNF mRNA; Pilocarpine results in increased expression of BDNF mRNA alternative form; Pilocarpine results in increased expression of BDNF protein
Pilocarpine results in decreased expression of BDNF protein
1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 1 alpha,24-dihydroxyvitamin D3 promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA alternative form]; [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA; Pilocarpine results in increased expression of and results in increased localization of BDNF protein; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
CTD PMID:8405262, PMID:8635431, PMID:8821376, PMID:9015327, PMID:9073163, PMID:11259499, PMID:12231234, PMID:14656328, PMID:15183516, PMID:15282290, PMID:15781040, PMID:19397936, PMID:19686240, PMID:21087489 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]; Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]
Pilocarpine results in increased expression of BECN1 mRNA; Pilocarpine results in increased expression of BECN1 protein
CTD PMID:17971868, PMID:19138675 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BMP4 mRNA
Pilocarpine results in increased expression of BMP4 mRNA
CTD PMID:17971868 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression EXP Pilocarpine results in increased expression of BNIP1 mRNA CTD PMID:17971868 NCBI chr10:16,677,077...16,689,321
Ensembl chr10:16,677,077...16,689,321
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Pilocarpine results in increased expression of BNIP3 mRNA CTD PMID:17971868 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1A protein
Pilocarpine results in increased expression of CACNA1A protein
CTD PMID:17265461 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1B mRNA; Pilocarpine results in decreased expression of CACNA1B protein
Pilocarpine results in increased expression of CACNA1B protein
CTD PMID:19811616 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1C protein
Pilocarpine results in increased expression of CACNA1C protein
CTD PMID:17265461 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1D protein
Pilocarpine results in increased expression of CACNA1D protein
CTD PMID:17265461 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Casp12 caspase 12 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
[Pilocarpine co-treated with Lithium] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Pilocarpine results in increased cleavage of and results in increased activity of CASP3 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Pilocarpine results in increased expression of CASP3 protein modified form
CTD PMID:12097334, PMID:18708038, PMID:18815271, PMID:19429016, PMID:19631748, PMID:19927300, PMID:20149694, PMID:21062633, PMID:22824136 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions EXP Pilocarpine results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:12097334 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp9 caspase 9 increases expression ISO Pilocarpine results in increased expression of CASP9 protein CTD PMID:18708038 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity
increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased activity of CAT protein
Pilocarpine results in increased expression of CAT protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]; Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
CTD PMID:15245787, PMID:15752349, PMID:16115668, PMID:17205390, PMID:17383094, PMID:18242586 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
decreases expression
EXP
ISO
Pilocarpine results in increased expression of CCL2 mRNA; Pilocarpine results in increased expression of CCL2 protein
Pilocarpine results in decreased expression of CCL2 protein
CTD PMID:15193289, PMID:17971868, PMID:19490431, PMID:20034406 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CCL3 protein
Pilocarpine results in increased expression of CCL3 mRNA
CTD PMID:19490431 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 decreases expression ISO Pilocarpine results in decreased expression of CCR10 mRNA; Pilocarpine results in decreased expression of CCR10 protein CTD PMID:17181556 NCBI chr10:89,086,556...89,088,993
Ensembl chr10:89,086,556...89,088,993
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
decreases expression
EXP
ISO
Pilocarpine results in increased expression of CCR2 protein
Pilocarpine results in decreased expression of CCR2 mRNA; Pilocarpine results in decreased expression of CCR2 protein
CTD PMID:19490431, PMID:20034406
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO Pilocarpine results in decreased expression of CCR3 mRNA; Pilocarpine results in decreased expression of CCR3 protein CTD PMID:19490431 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO Pilocarpine results in decreased expression of CCR7 mRNA; Pilocarpine results in decreased expression of CCR7 protein CTD PMID:17181556 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO Pilocarpine results in decreased expression of CCR8 mRNA; Pilocarpine results in decreased expression of CCR8 protein CTD PMID:17181556 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 decreases expression ISO Pilocarpine results in decreased expression of CCR9 mRNA; Pilocarpine results in decreased expression of CCR9 protein CTD PMID:17181556 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
EXP Pilocarpine results in increased expression of CD40 protein
rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]
CTD PMID:18455351 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Pilocarpine results in increased expression of CD44 protein CTD PMID:15191797 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CDH1 protein
Pilocarpine results in increased expression of CDH1 protein
CTD PMID:12387456 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Pilocarpine results in increased expression of CDH2 mRNA; Pilocarpine results in increased expression of CDH2 protein CTD PMID:12125071, PMID:12387456 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Pilocarpine results in increased expression of CDK1 mRNA CTD PMID:14656328 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Pilocarpine results in increased expression of CDK2 mRNA CTD PMID:17971868 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Pilocarpine results in increased expression of CDKN1B mRNA CTD PMID:17971868 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CDKN2A mRNA
Pilocarpine results in increased expression of CDKN2A mRNA
CTD PMID:17971868 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of CEBPA mRNA] CTD PMID:32494933 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions
decreases expression
EXP Pilocarpine results in decreased activity of CHAT protein
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein
Pilocarpine results in decreased expression of CHAT protein
CTD PMID:19669875, PMID:19932735, PMID:19941057 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
increases expression
affects binding
decreases expression
increases activity
affects response to substance
ISO
EXP
[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]
Pilocarpine results in increased expression of CHRM1 protein
CHRM1 protein binds to Pilocarpine
Pilocarpine results in decreased expression of CHRM1 protein
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
CHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]
CHRM1 protein affects the susceptibility to Pilocarpine
CTD PMID:9224827, PMID:11527950, PMID:12713643, PMID:14559291, PMID:15967574, PMID:16137708, PMID:16563474, PMID:32234387 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression
increases expression
multiple interactions
affects binding
EXP
ISO
Pilocarpine results in decreased expression of CHRM2 protein
Pilocarpine results in increased expression of CHRM2 protein
eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]
CHRM2 protein binds to Pilocarpine
Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD PMID:9224827, PMID:14559291, PMID:32234387 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
increases expression
affects binding
ISO brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
Pilocarpine results in increased expression of CHRM3 protein
CHRM3 protein binds to Pilocarpine
CTD PMID:9224827, PMID:32234387 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
increases expression
affects binding
EXP
ISO
Pilocarpine binds to and results in increased activity of CHRM4 protein
Pilocarpine results in increased expression of CHRM4 protein
CHRM4 protein binds to Pilocarpine
brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; eburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]
CTD PMID:9224827, PMID:9920179, PMID:32234387 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 increases expression ISO Pilocarpine results in increased expression of CHRM5 protein CTD PMID:32234387 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Cib1 calcium and integrin binding 1 increases expression EXP Pilocarpine results in increased expression of CIB1 mRNA CTD PMID:17971868 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525
JBrowse link
G Clcn2 chloride voltage-gated channel 2 affects expression EXP Pilocarpine affects the expression of CLCN2 protein CTD PMID:16930566 NCBI chr11:82,862,664...82,876,165
Ensembl chr11:83,883,879...83,897,394
JBrowse link
G Cnn3 calponin 3 increases expression EXP Pilocarpine results in increased expression of CNN3 protein CTD PMID:14620880 NCBI chr 2:225,005,069...225,036,179
Ensembl chr 2:225,005,019...225,036,188
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Pilocarpine results in decreased expression of CNR1 protein CTD PMID:19368833 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Pilocarpine results in increased expression of CNTF mRNA CTD PMID:10506506 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CSF2 mRNA
Pilocarpine results in increased expression of CSF2 mRNA
CTD PMID:17971868 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression EXP Pilocarpine results in increased expression of CSF2RB mRNA CTD PMID:17166730 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Csn2 casein beta decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CSN2 mRNA
Pilocarpine results in increased expression of CSN2 mRNA
CTD PMID:17971868 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Ctf1 cardiotrophin 1 increases expression EXP Pilocarpine results in increased expression of CTF1 mRNA CTD PMID:10506506 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Pilocarpine results in increased expression of CTNNB1 protein CTD PMID:12387456 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsd cathepsin D increases expression EXP Pilocarpine results in increased expression of CTSD mRNA CTD PMID:17971868 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Pilocarpine results in increased expression of CYP11A1 protein CTD PMID:19125849 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Dap3 death associated protein 3 increases expression EXP Pilocarpine results in increased expression of DAP3 mRNA CTD PMID:17971868 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dclre1a DNA cross-link repair 1A increases expression EXP Pilocarpine results in increased expression of DCLRE1A mRNA CTD PMID:17971868 NCBI chr 1:277,335,792...277,355,701
Ensembl chr 1:277,335,790...277,355,075
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Pilocarpine results in increased expression of DDIT3 mRNA CTD PMID:17971868 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dmd dystrophin decreases expression EXP Pilocarpine results in decreased expression of DMD protein CTD PMID:20886625 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Pilocarpine results in increased expression of DPYSL2 protein CTD PMID:17366478 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression
multiple interactions
increases response to substance
EXP
ISO
Pilocarpine results in increased expression of DRD1 mRNA
Pilocarpine results in decreased expression of DRD1 protein
Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]
DRD1 protein results in increased susceptibility to Pilocarpine
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine; [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine
CTD PMID:1365435, PMID:7906944, PMID:14656328, PMID:15876489, PMID:16137708 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases expression
decreases response to substance
decreases activity
EXP
ISO
[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]
Pilocarpine results in decreased expression of DRD2 protein
DRD2 protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased activity of DRD2 protein
CTD PMID:1365435, PMID:11860278, PMID:14559291, PMID:15140183, PMID:15876489, PMID:16137708 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Efna3 ephrin A3 decreases expression EXP Pilocarpine results in decreased expression of EFNA3 mRNA CTD PMID:18772502 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP Pilocarpine results in decreased expression of EGFR mRNA CTD PMID:17971868 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of EGR1 mRNA
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]
CTD PMID:7968354 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 multiple interactions
increases expression
EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 multiple interactions
increases expression
EXP Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
Pilocarpine results in increased expression of EGR3 mRNA; Pilocarpine results in increased expression of EGR3 protein
CTD PMID:16091474 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression EXP Pilocarpine results in decreased expression of EI24 mRNA CTD PMID:17971868 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein CTD PMID:16492139 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases activity
ISO Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]
Pilocarpine results in increased activity of EIF2AK3 protein
CTD PMID:16492139 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]
Pilocarpine results in increased phosphorylation of EIF2S1 protein
CTD PMID:15003282, PMID:16492139 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Epha5 EPH receptor A5 decreases expression EXP Pilocarpine results in decreased expression of EPHA5 mRNA; Pilocarpine results in decreased expression of EPHA5 protein CTD PMID:18772502 NCBI chr14:25,589,312...25,958,258
Ensembl chr14:25,589,762...25,958,227
JBrowse link
G Epo erythropoietin increases expression EXP Pilocarpine results in increased expression of EPO mRNA CTD PMID:17166730 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor increases expression EXP Pilocarpine results in increased expression of EPOR mRNA CTD PMID:17166730 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression EXP Pilocarpine results in increased expression of ERCC1 mRNA CTD PMID:17971868 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression EXP Pilocarpine results in increased expression of ERCC3 mRNA CTD PMID:17971868 NCBI chr18:25,037,668...25,068,380
Ensembl chr18:25,037,625...25,068,389
JBrowse link
G Ezr ezrin increases expression EXP Pilocarpine results in increased expression of EZR protein CTD PMID:17366478 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein] CTD PMID:21087489 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression EXP Pilocarpine results in increased expression of FGF5 mRNA CTD PMID:8167846 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression
EXP [Pilocarpine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS protein; [Pilocarpine co-treated with Lithium] results in increased expression of FOS protein; [Pilocarpine co-treated with SCH 23390] results in increased expression of FOS protein; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of FOS mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Pilocarpine results in decreased expression of FOS mRNA
Pilocarpine results in increased expression of FOS mRNA; Pilocarpine results in increased expression of FOS protein
CTD PMID:7713058, PMID:7968354, PMID:7984056, PMID:8281324, PMID:8511714, PMID:9630518, PMID:17971868 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Pilocarpine results in increased expression of FOSB protein CTD PMID:16391389 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Pilocarpine results in decreased expression of FSHB protein CTD PMID:9761326 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases expression
EXP bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA] CTD PMID:20821261 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of GABRA4 protein
Pilocarpine results in increased expression of GABRA4 mRNA
Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
CTD PMID:15456836, PMID:16091474 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
decreases expression
EXP bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA] CTD PMID:20821261 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta multiple interactions
decreases expression
EXP
ISO
bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]
Pilocarpine results in decreased expression of GABRD protein
CTD PMID:15456836, PMID:20821261 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Pilocarpine results in increased expression of GABRG2 protein CTD PMID:15456836 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Pilocarpine results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 affects expression
increases expression
decreases expression
EXP Pilocarpine affects the expression of GAD2 protein
Pilocarpine results in increased expression of GAD2 mRNA; Pilocarpine results in increased expression of GAD2 protein
Pilocarpine results in decreased expression of GAD2 protein
CTD PMID:12183020, PMID:15857427, PMID:15987249, PMID:16797850 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gap43 growth associated protein 43 decreases expression
increases expression
ISO
EXP
Pilocarpine results in decreased expression of GAP43 protein
Pilocarpine results in increased expression of GAP43 mRNA
CTD PMID:15191797, PMID:16134595 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
multiple interactions
EXP Pilocarpine results in increased expression of GDNF mRNA
[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein
CTD PMID:7854063, PMID:12914250 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression
EXP [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP protein
Pilocarpine results in decreased expression of GFAP protein
CTD PMID:25101675, PMID:31018114 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
affects localization
EXP Pilocarpine results in increased expression of GJA1 protein
Pilocarpine affects the localization of GJA1 protein
CTD PMID:21177194 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA] CTD PMID:32494933 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Pilocarpine results in decreased expression of GLUL protein CTD PMID:25101675 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO Pilocarpine results in increased secretion of GPT protein CTD PMID:32234387 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of GRIA1 mRNA
Pilocarpine results in increased expression of GRIA1 protein
CTD PMID:7529610, PMID:15857427 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
decreases expression
increases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA
Pilocarpine results in decreased expression of GRIA2 mRNA
Pilocarpine results in increased expression of GRIA2 3' UTR alternative form; Pilocarpine results in increased expression of GRIA2 protein
CTD PMID:15857427, PMID:16819974, PMID:19222700 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions
increases expression
decreases expression
EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA
Pilocarpine results in increased expression of GRIA3 mRNA; Pilocarpine results in increased expression of GRIA3 protein
Pilocarpine results in decreased expression of GRIA3 mRNA
CTD PMID:7529610, PMID:15857427, PMID:16819974 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions EXP [Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine CTD PMID:12080343 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA CTD PMID:16819974 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA CTD PMID:16819974 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
decreases expression
EXP Plant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA] CTD PMID:18086456 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
increases expression
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]
Pilocarpine results in decreased expression of GRIN2A protein
CTD PMID:15857427, PMID:16600505, PMID:22824136 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression
increases expression
multiple interactions
EXP Pilocarpine results in decreased expression of GRIN2B protein
Pilocarpine results in increased expression of GRIN2B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]
CTD PMID:15857427, PMID:16600505, PMID:22824136 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression
multiple interactions
increases expression
EXP Pilocarpine results in decreased expression of GRM1 protein
[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of GRM1 mRNA
Pilocarpine results in increased expression of GRM1 protein
CTD PMID:11463519, PMID:32494933 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm2 glutamate metabotropic receptor 2 decreases expression EXP Pilocarpine results in decreased expression of GRM2 mRNA; Pilocarpine results in decreased expression of GRM2 protein CTD PMID:16793029, PMID:18585369, PMID:18804094 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link
G Grm3 glutamate metabotropic receptor 3 decreases expression EXP Pilocarpine results in decreased expression of GRM3 mRNA; Pilocarpine results in decreased expression of GRM3 protein CTD PMID:16793029, PMID:18585369, PMID:18804094 NCBI chr 4:21,316,761...21,567,561
Ensembl chr 4:21,317,695...21,560,490
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
decreases expression
EXP [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased expression of GRM5 mRNA; Pilocarpine results in decreased expression of GRM5 protein
CTD PMID:15009663, PMID:17634364 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Grm8 glutamate metabotropic receptor 8 increases expression
decreases expression
EXP Pilocarpine results in increased expression of GRM8 protein
Pilocarpine results in decreased expression of GRM8
CTD PMID:11226630, PMID:12539201 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions
decreases expression
EXP [Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA
Pilocarpine results in decreased expression of HCN1 protein
CTD PMID:12890777, PMID:21905079 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression EXP Pilocarpine results in increased expression of HIF1A mRNA CTD PMID:17166730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hk2 hexokinase 2 increases expression EXP Pilocarpine results in increased expression of HK2 mRNA CTD PMID:17971868 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
Pilocarpine results in increased expression of HMOX1 protein
Pilocarpine results in increased expression of HMOX1 mRNA
CTD PMID:20971094, PMID:25715797, PMID:32234387 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxb1 homeo box B1 decreases expression EXP Pilocarpine results in decreased expression of HOXB1 mRNA CTD PMID:17971868 NCBI chr10:84,214,358...84,215,812
Ensembl chr10:84,214,358...84,215,687
JBrowse link
G Hrk harakiri, BCL2 interacting protein decreases expression EXP Pilocarpine results in decreased expression of HRK mRNA CTD PMID:17971868 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsbp1 heat shock factor binding protein 1 decreases expression EXP Pilocarpine results in decreased expression of HSBP1 mRNA CTD PMID:17971868 NCBI chr19:51,985,196...51,989,528
Ensembl chr19:51,985,170...51,989,544
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein; Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein] CTD PMID:21429313 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Pilocarpine results in increased expression of HSPB1 mRNA; Pilocarpine results in increased expression of HSPB1 protein CTD PMID:17971868, PMID:20971094 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine; [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine CTD PMID:2533336, PMID:15140183 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP [cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine CTD PMID:2533336 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression
decreases expression
EXP Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]
Pilocarpine results in increased expression of HTR2C mRNA; Pilocarpine results in increased expression of HTR2C protein
Pilocarpine results in decreased expression of HTR2C mRNA; Pilocarpine results in decreased expression of HTR2C protein
CTD PMID:19439326, PMID:19700373 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP 1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IFNG protein] CTD PMID:15781040 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression EXP Pilocarpine results in increased expression of IGFBP3 mRNA CTD PMID:17971868 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
increases expression
EXP 1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IL10 protein]
Pilocarpine results in increased expression of IL10 protein
CTD PMID:15781040, PMID:17872965 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases expression ISO Pilocarpine results in increased expression of IL12B mRNA CTD PMID:15193289 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO
EXP
[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
Pilocarpine results in increased expression of IL1B mRNA; Pilocarpine results in increased expression of IL1B protein
Pilocarpine results in decreased expression of IL1B mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]
CTD PMID:19010416, PMID:19055492, PMID:19951488, PMID:21087489, PMID:23211629, PMID:31018114 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression EXP Pilocarpine results in decreased expression of IL2 mRNA CTD PMID:17971868 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4r interleukin 4 receptor increases expression EXP Pilocarpine results in increased expression of IL4R mRNA CTD PMID:17971868 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of IL6 mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 protein
CTD PMID:19055492, PMID:31018114 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilk integrin-linked kinase decreases activity ISO Pilocarpine results in decreased activity of ILK protein CTD PMID:19631748 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Impa1 inositol monophosphatase 1 increases response to substance
decreases response to substance
affects response to substance
ISO IMPA1 gene mutant form results in increased susceptibility to Pilocarpine
IMPA1 protein results in decreased susceptibility to Pilocarpine
IMPA1 protein affects the susceptibility to Pilocarpine
CTD PMID:17460611, PMID:17602744, PMID:19754464 NCBI chr 2:93,675,203...93,696,355
Ensembl chr 2:93,675,203...93,696,232
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression EXP Pilocarpine results in increased expression of ITGA1 protein CTD PMID:12851778 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga2 integrin subunit alpha 2 increases expression EXP Pilocarpine results in increased expression of ITGA2 protein CTD PMID:12851778 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression EXP Pilocarpine results in increased expression of ITGA4 protein CTD PMID:12851778 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression EXP Pilocarpine results in increased expression of ITGA5 protein CTD PMID:12851778 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression
increases expression
ISO
EXP
Pilocarpine results in decreased expression of ITGB1 protein
Pilocarpine results in increased expression of ITGB1 protein
CTD PMID:12851778, PMID:19631748 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression EXP Pilocarpine results in increased expression of ITGB3 protein CTD PMID:12851778 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb4 integrin subunit beta 4 increases expression EXP Pilocarpine results in increased expression of ITGB4 protein CTD PMID:12851778 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of JUN protein; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056, PMID:17971868, PMID:19430551 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354, PMID:7984056 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 decreases expression EXP Pilocarpine results in decreased expression of KCNC4 mRNA; Pilocarpine results in decreased expression of KCNC4 protein CTD PMID:20971086 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455
JBrowse link
G Kcnk5 potassium two pore domain channel subfamily K member 5 increases expression
decreases expression
EXP Pilocarpine results in increased expression of KCNK5 protein
Pilocarpine results in decreased expression of KCNK5 protein
CTD PMID:19220408 NCBI chr15:4,554,603...4,597,000
Ensembl chr15:4,554,603...4,597,000
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 decreases expression EXP Pilocarpine results in decreased expression of KCNMA1 mRNA CTD PMID:18695509 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases expression EXP Pilocarpine results in decreased expression of KCNN1 protein CTD PMID:20553876 NCBI chr16:20,325,270...20,349,163
Ensembl chr16:20,336,638...20,348,804
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression EXP Pilocarpine results in decreased expression of KCNN2 mRNA; Pilocarpine results in decreased expression of KCNN2 protein CTD PMID:20553876 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Kcnn3 potassium calcium-activated channel subfamily N member 3 decreases expression EXP Pilocarpine results in decreased expression of KCNN3 mRNA; Pilocarpine results in decreased expression of KCNN3 protein CTD PMID:20553876 NCBI chr 2:188,837,280...188,991,794
Ensembl chr 2:188,844,073...188,988,774
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Pilocarpine results in increased expression of LAMP2 protein]
Pilocarpine results in increased expression of LAMP2 mRNA; Pilocarpine results in increased expression of LAMP2 protein
CTD PMID:19272430 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Pilocarpine results in decreased expression of LHB protein CTD PMID:9761326 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression EXP Pilocarpine results in increased expression of LIF mRNA CTD PMID:10506506 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Pilocarpine results in increased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12091480, PMID:17360923, PMID:18988310, PMID:19402951, PMID:22824136 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
Pilocarpine results in increased phosphorylation of MAPK3 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
CTD PMID:12091480, PMID:17360923, PMID:18988310, PMID:19402951, PMID:22824136 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; W 7 inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mef2c myocyte enhancer factor 2C increases expression EXP Pilocarpine results in increased expression of MEF2C mRNA CTD PMID:18949272 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Pilocarpine results in increased expression of MGMT mRNA CTD PMID:17971868 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir200c microRNA 200c multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] results in increased expression of MIR200C mRNA CTD PMID:31018114 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
ISO Pilocarpine results in increased activity of MMP9 protein
Pilocarpine results in increased expression of MMP9 protein
CTD PMID:19631748 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease increases expression EXP Pilocarpine results in increased expression of MRE11A mRNA CTD PMID:17971868 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Msn moesin increases expression EXP Pilocarpine results in increased expression of MSN mRNA CTD PMID:14656328 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
EXP dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein] CTD PMID:23211629 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression EXP Pilocarpine results in increased expression of MYD88 mRNA CTD PMID:17971868 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression EXP Pilocarpine results in decreased expression of NAIP2 mRNA CTD PMID:17971868 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 decreases expression ISO Pilocarpine results in decreased expression of NFAT5 mRNA CTD PMID:21219332 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Pilocarpine results in increased expression of NFE2L2 protein CTD PMID:32234387 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Pilocarpine results in increased expression of NFKBIA mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]
CTD PMID:15193289, PMID:23211629 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Ketamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA] CTD PMID:8635431, PMID:8821376, PMID:15183516, PMID:17971868 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor increases expression
multiple interactions
increases response to substance
ISO
EXP
Pilocarpine results in increased expression of NGFR protein
Pilocarpine results in increased expression of NGFR mRNA; Pilocarpine results in increased expression of NGFR protein
PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]
NGFR protein results in increased susceptibility to Pilocarpine
CTD PMID:10436046, PMID:12097334, PMID:18815271, PMID:21084616 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS1 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein] CTD PMID:18672383, PMID:20149694 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS2 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]
Pilocarpine results in increased expression of NOS2 mRNA; Pilocarpine results in increased expression of NOS2 protein
CTD PMID:18672383, PMID:20149694, PMID:23211629 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nova1 NOVA alternative splicing regulator 1 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of NOVA1 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]
CTD PMID:20470870 NCBI chr 6:66,960,126...67,085,836
Ensembl chr 6:66,963,510...67,085,390
JBrowse link
G Nova2 NOVA alternative splicing regulator 2 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of NOVA2 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]
CTD PMID:20470870 NCBI chr 1:79,831,737...79,866,147
Ensembl chr 1:79,831,534...79,865,807
JBrowse link
G Nptx2 neuronal pentraxin 2 increases expression EXP Pilocarpine results in increased expression of NPTX2 mRNA CTD PMID:14656328 NCBI chr12:12,014,638...12,025,547
Ensembl chr12:12,013,911...12,025,549
JBrowse link
G Npy neuropeptide Y decreases response to substance
increases expression
ISO
EXP
NPY protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in increased expression of NPY protein
CTD PMID:12231234, PMID:12821374, PMID:15451008 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Pilocarpine results in increased expression of NQO1 protein CTD PMID:32234387 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 protein] CTD PMID:32494933 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of NTF3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]
CTD PMID:8635431 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases expression
EXP Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] CTD PMID:8635431, PMID:8821376, PMID:15183516, PMID:19686240 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of NTRK3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]
CTD PMID:8635431 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Pilocarpine results in increased expression of ODC1 mRNA CTD PMID:17971868 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression EXP Pilocarpine results in decreased expression of OGG1 mRNA; Pilocarpine results in decreased expression of OGG1 protein CTD PMID:20206232 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 protein results in decreased susceptibility to Pilocarpine CTD PMID:7894264 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 decreases expression EXP Pilocarpine results in decreased expression of OPRM1 protein CTD PMID:17919468 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Osm oncostatin M increases expression EXP Pilocarpine results in increased expression of OSM mRNA CTD PMID:10506506 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression EXP Pilocarpine results in increased expression of P2RX7 protein CTD PMID:19138473 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression
multiple interactions
EXP Pilocarpine affects the expression of PARP1 protein
3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; [Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]
CTD PMID:25101675, PMID:31396050 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Pilocarpine results in increased expression of PCNA mRNA CTD PMID:17971868 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression EXP Pilocarpine results in increased expression of PCSK1 mRNA CTD PMID:9015327 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pdxk pyridoxal kinase increases expression EXP Pilocarpine results in increased expression of PDXK protein CTD PMID:19356691 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 multiple interactions EXP [Pilocarpine co-treated with Lithium Chloride co-treated with 3-chloroacetylindole] results in decreased phosphorylation of PEA15 protein; [Pilocarpine co-treated with Lithium Chloride] results in decreased phosphorylation of PEA15 protein CTD PMID:31396050 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466
JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression ISO Pilocarpine results in increased expression of PLCB4 protein CTD PMID:18774262 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase increases expression EXP Pilocarpine results in increased expression of PNKP mRNA CTD PMID:17971868 NCBI chr 1:100,853,475...100,859,202
Ensembl chr 1:100,853,902...100,859,084
JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase increases expression EXP Pilocarpine results in increased expression of PNPO protein CTD PMID:19356691 NCBI chr10:84,874,926...84,881,190
Ensembl chr10:84,874,927...84,881,190
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression EXP Pilocarpine results in increased expression of POLG mRNA; Pilocarpine results in increased expression of POLG protein CTD PMID:20446108 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Pilocarpine results in increased expression of PPP1R15A protein CTD PMID:16492139 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Pilocarpine results in decreased expression of PPP3R1 mRNA CTD PMID:14656328 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Prkcb protein kinase C, beta increases expression
decreases expression
ISO
EXP
Pilocarpine results in increased expression of PRKCB protein
Pilocarpine results in decreased expression of PRKCB mRNA
CTD PMID:15058486, PMID:17971868, PMID:18774262 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases expression EXP Pilocarpine results in increased expression of PRKCD protein CTD PMID:15058486 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcg protein kinase C, gamma increases expression ISO
EXP
Pilocarpine results in increased expression of PRKCG protein CTD PMID:15058486, PMID:18774262 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Prkch protein kinase C, eta increases expression EXP Pilocarpine results in increased expression of PRKCH protein CTD PMID:15058486 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Pilocarpine results in increased expression of PRKCZ protein CTD PMID:15058486 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein] CTD PMID:21084616 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Pilocarpine results in increased expression of PTGES mRNA CTD PMID:15193289 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of PTGS2 mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]
Pilocarpine results in increased expression of PTGS2 mRNA; Pilocarpine results in increased expression of PTGS2 protein
CTD PMID:15193289, PMID:23211629 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein
Pilocarpine results in increased phosphorylation of PTK2 protein
CTD PMID:10537051 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions
decreases response to substance
ISO PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PTPN5 protein mutant form results in decreased susceptibility to Pilocarpine
CTD PMID:17360923, PMID:21204826 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 affects expression EXP Pilocarpine affects the expression of PTPRZ1 protein CTD PMID:10582521 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Pvalb parvalbumin decreases expression EXP Pilocarpine results in decreased expression of PVALB protein CTD PMID:12183020 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Qdpr quinoid dihydropteridine reductase increases expression EXP Pilocarpine results in increased expression of QDPR protein CTD PMID:17366478 NCBI chr14:70,164,682...70,178,284
Ensembl chr14:70,164,650...70,178,284
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression
decreases expression
EXP Pilocarpine results in increased expression of RAD23A mRNA
Pilocarpine results in decreased expression of RAD23A mRNA
CTD PMID:17971868 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein increases expression EXP Pilocarpine results in increased expression of RAD23B mRNA CTD PMID:17971868 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK mRNA; [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK protein CTD PMID:31018114 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; [Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein] CTD PMID:31396050 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ret ret proto-oncogene multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of RET protein CTD PMID:12914250 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Rpl32 ribosomal protein L32 multiple interactions ISO Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein] CTD PMID:16492139 NCBI chr 4:147,715,480...147,719,044
Ensembl chr 6:145,777,318...145,777,767
Ensembl chr 4:145,777,318...145,777,767
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
EXP dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein] CTD PMID:23211629 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Pilocarpine results in increased expression of S100B protein CTD PMID:18226170 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases response to substance ISO SCN2B protein results in decreased susceptibility to Pilocarpine CTD PMID:12481039 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 increases expression EXP Pilocarpine results in increased expression of SCN8A mRNA; Pilocarpine results in increased expression of SCN8A protein CTD PMID:19306853 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
EXP dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Niacinamide inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein] CTD PMID:23211629 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO
EXP
Pilocarpine results in increased expression of SLC12A2 mRNA; Pilocarpine results in increased expression of SLC12A2 protein CTD PMID:18550034, PMID:19674083 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc12a5 solute carrier family 12 member 5 decreases expression
multiple interactions
increases degradation
ISO
EXP
Pilocarpine results in decreased expression of SLC12A5 mRNA; Pilocarpine results in decreased expression of SLC12A5 protein
Pilocarpine results in increased phosphorylation of and affects the localization of SLC12A5 protein
Pilocarpine results in increased degradation of SLC12A5 protein
CTD PMID:18094240, PMID:18550034, PMID:19674083, PMID:20600929 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression EXP Pilocarpine results in increased expression of SLC17A7 protein CTD PMID:17503488 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP Pilocarpine results in increased expression of SLC1A1 mRNA; Pilocarpine results in increased expression of SLC1A1 protein CTD PMID:11906504 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pilocarpine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc32a1 solute carrier family 32 member 1 increases expression EXP Pilocarpine results in increased expression of SLC32A1 mRNA; Pilocarpine results in increased expression of SLC32A1 protein CTD PMID:17503488 NCBI chr 3:155,102,980...155,107,815
Ensembl chr 3:155,103,150...155,107,817
JBrowse link
G Slc5a3 solute carrier family 5 member 3 increases response to substance
increases expression
affects response to substance
ISO SLC5A3 gene mutant form results in increased susceptibility to Pilocarpine
Pilocarpine results in increased expression of SLC5A3 mRNA
SLC5A3 protein affects the susceptibility to Pilocarpine
CTD PMID:17602744, PMID:19754464, PMID:21219332 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases expression EXP
ISO
Pilocarpine results in decreased expression of SLC6A1 protein
Pilocarpine results in decreased expression of SLC6A1 mRNA
CTD PMID:12183020, PMID:21219332 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
G Slc6a11 solute carrier family 6 member 11 decreases expression ISO Pilocarpine results in decreased expression of SLC6A11 mRNA CTD PMID:21219332 NCBI chr 4:146,106,386...146,223,228
Ensembl chr 4:146,106,386...146,223,228
JBrowse link
G Slc6a12 solute carrier family 6 member 12 decreases expression
increases expression
ISO Pilocarpine results in decreased expression of SLC6A12 mRNA
Pilocarpine results in increased expression of SLC6A12 mRNA
CTD PMID:21219332 NCBI chr 4:153,921,199...153,941,333
Ensembl chr 4:153,921,115...153,941,391
JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression ISO Pilocarpine results in increased expression of SLC6A6 mRNA CTD PMID:21219332 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP Pilocarpine results in decreased expression of SLCO1A4 protein CTD PMID:19570321 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slit2 slit guidance ligand 2 increases expression
decreases expression
EXP Pilocarpine results in increased expression of SLIT2 protein
Pilocarpine results in decreased expression of SLIT2 protein
CTD PMID:20153733 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression EXP Pilocarpine results in increased expression of SMC3 mRNA CTD PMID:17971868 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Snta1 syntrophin, alpha 1 decreases expression EXP Pilocarpine results in decreased expression of SNTA1 protein CTD PMID:20886625 NCBI chr 3:149,874,023...149,905,980
Ensembl chr 3:149,874,030...149,905,944
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Pilocarpine results in increased expression of SOD2 protein CTD PMID:20446108 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sparcl1 SPARC like 1 affects localization
decreases expression
EXP Pilocarpine affects the localization of SPARCL1 protein
Pilocarpine results in decreased expression of SPARCL1 protein
CTD PMID:18488994, PMID:18808451 NCBI chr14:6,994,261...7,025,309
Ensembl chr14:6,994,190...7,025,308
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of SRC protein CTD PMID:16600505 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sstr1 somatostatin receptor 1 increases expression EXP Pilocarpine results in increased expression of SSTR1 protein CTD PMID:18951627 NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression EXP Pilocarpine results in increased expression of SSTR2 protein CTD PMID:18951627 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
JBrowse link
G Sstr3 somatostatin receptor 3 decreases expression EXP Pilocarpine results in decreased expression of SSTR3 protein CTD PMID:18951627 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Sstr4 somatostatin receptor 4 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of SSTR4 protein
Pilocarpine results in increased expression of SSTR4 protein
CTD PMID:18951627 NCBI chr 3:142,739,781...142,741,644
Ensembl chr 3:142,739,781...142,741,644
JBrowse link
G Sstr5 somatostatin receptor 5 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of SSTR5 protein
Pilocarpine results in increased expression of SSTR5 protein
CTD PMID:18951627 NCBI chr10:14,847,749...14,853,827
Ensembl chr10:14,847,749...14,853,827
JBrowse link
G Star steroidogenic acute regulatory protein increases localization EXP Pilocarpine results in increased localization of STAR protein CTD PMID:20609383 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stard6 StAR-related lipid transfer domain containing 6 increases localization
increases expression
EXP Pilocarpine results in increased localization of STARD6 protein
Pilocarpine results in increased expression of STARD6 protein
CTD PMID:19434006, PMID:20609383 NCBI chr18:68,983,491...69,004,868
Ensembl chr18:68,983,545...69,000,993
JBrowse link
G Syp synaptophysin increases expression EXP Pilocarpine results in increased expression of SYP protein CTD PMID:16134595 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 protein modified form; Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] CTD PMID:11074153 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tdg thymine-DNA glycosylase increases expression EXP Pilocarpine results in increased expression of TDG mRNA CTD PMID:17971868 NCBI chr 7:27,194,000...27,213,676
Ensembl chr 7:27,193,998...27,214,236
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Pilocarpine results in increased expression of TFAM mRNA; Pilocarpine results in increased expression of TFAM protein CTD PMID:20446108 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Thrb thyroid hormone receptor beta increases expression EXP Pilocarpine results in increased expression of THRB mRNA CTD PMID:14656328 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Pilocarpine results in increased expression of TIMP2 mRNA CTD PMID:14656328 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Pilocarpine results in decreased expression of TJP1 protein CTD PMID:17533168 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Pilocarpine results in increased expression of TLR2 mRNA CTD PMID:15193289 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of TLR4 mRNA] CTD PMID:32494933 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnc tenascin C increases expression EXP Pilocarpine results in increased expression of TNC mRNA CTD PMID:14656328 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of TNF mRNA
Pilocarpine results in increased expression of TNF protein
Pilocarpine results in decreased expression of TNF mRNA; Pilocarpine results in decreased expression of TNF protein
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF protein; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of TNF protein]
CTD PMID:15193289, PMID:17872965, PMID:18455351, PMID:19055492, PMID:31018114 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Pilocarpine results in increased expression of TNFRSF1A mRNA CTD PMID:17971868 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Pilocarpine results in decreased expression of TNFSF10 mRNA CTD PMID:17971868 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Pilocarpine results in decreased expression of TNFSF13 mRNA CTD PMID:17971868 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnr tenascin R increases expression EXP Pilocarpine results in increased expression of TNR protein CTD PMID:15120744 NCBI chr13:77,602,249...77,678,385
Ensembl chr13:77,485,113...77,678,437
JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression EXP Pilocarpine results in increased expression of TREX1 mRNA CTD PMID:17971868 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Trh thyrotropin releasing hormone increases expression EXP Pilocarpine results in increased expression of TRH mRNA CTD PMID:10443546, PMID:15781040 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases activity
decreases expression
EXP Pilocarpine results in decreased activity of TRHR protein
Pilocarpine results in decreased expression of TRHR protein
CTD PMID:10443546 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 increases expression EXP Pilocarpine results in increased expression of UBE2D3 mRNA CTD PMID:17971868 NCBI chr 2:240,626,198...240,655,874
Ensembl chr 2:240,627,436...240,655,246
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression EXP Pilocarpine results in increased expression of UBE2I mRNA CTD PMID:17971868 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Vdr vitamin D receptor increases expression EXP Pilocarpine results in increased expression of VDR mRNA CTD PMID:18534255 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Pilocarpine results in increased expression of VEGFA protein CTD PMID:17533168 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP Pilocarpine results in increased expression of VGF mRNA CTD PMID:14656328 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases expression EXP Pilocarpine results in increased expression of XRCC1 mRNA CTD PMID:17971868 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression EXP Pilocarpine results in increased expression of XRCC3 mRNA CTD PMID:17971868 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
G Zfp110 zinc finger protein 110 multiple interactions ISO ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein] CTD PMID:18815271 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528
JBrowse link
(Z)-3-butylidenephthalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP
ISO
butylidenephthalide results in increased expression of AIFM1 protein CTD PMID:16987298, PMID:23770345 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Anxa5 annexin A5 decreases expression ISO butylidenephthalide results in decreased expression of ANXA5 protein CTD PMID:23770345 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO butylidenephthalide results in increased expression of ARHGAP1 protein CTD PMID:23770345 NCBI chr 3:80,555,196...80,576,881
Ensembl chr 3:80,555,196...80,576,856
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO butylidenephthalide results in increased expression of ARHGDIA protein CTD PMID:23770345 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO butylidenephthalide results in increased expression of ATP5F1A protein CTD PMID:23770345 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO butylidenephthalide results in decreased expression of ATP5F1B protein CTD PMID:23770345 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP
ISO
butylidenephthalide results in increased expression of BAX protein CTD PMID:16987298 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bik BCL2-interacting killer increases expression ISO butylidenephthalide results in increased expression of BIK protein CTD PMID:23770345 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO butylidenephthalide results in increased expression of C1QBP protein CTD PMID:23770345 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calr calreticulin decreases expression ISO butylidenephthalide results in decreased expression of CALR protein CTD PMID:23770345 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Casp3 caspase 3 increases cleavage ISO
EXP
butylidenephthalide results in increased cleavage of CASP3 protein CTD PMID:16987298 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO
EXP
butylidenephthalide results in increased cleavage of CASP8 protein CTD PMID:16987298 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage EXP
ISO
butylidenephthalide results in increased cleavage of CASP9 protein CTD PMID:16987298 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CCND1 protein CTD PMID:16987298, PMID:23770345 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO
EXP
butylidenephthalide results in decreased expression of CCNE1 protein CTD PMID:16987298 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CDK2 protein CTD PMID:16987298, PMID:23770345 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CDK4 protein CTD PMID:16987298 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression EXP
ISO
butylidenephthalide results in decreased expression of CDK6 protein CTD PMID:16987298 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
EXP
ISO
butylidenephthalide results in decreased expression of CDKN1A protein
butylidenephthalide results in increased expression of CDKN1A protein
CTD PMID:16987298, PMID:23770345 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP butylidenephthalide results in increased expression of CDKN1B protein CTD PMID:16987298 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO butylidenephthalide results in increased expression of CDKN2A protein CTD PMID:16987298, PMID:23770345 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO butylidenephthalide results in increased expression of CYCS protein CTD PMID:23770345 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO butylidenephthalide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
butylidenephthalide results in increased expression of CYP1A1 mRNA
CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO butylidenephthalide results in increased expression of DDIT3 protein CTD PMID:23770345 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO butylidenephthalide results in decreased expression of EEF1A1 protein CTD PMID:23770345 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO butylidenephthalide results in decreased expression of EEF1A2 protein CTD PMID:23770345 NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO butylidenephthalide results in increased expression of EEF2 protein CTD PMID:23770345 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 decreases expression ISO butylidenephthalide results in decreased expression of EIF4A1 protein CTD PMID:23770345 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 decreases expression ISO butylidenephthalide results in decreased expression of ELAVL1 protein CTD PMID:23770345 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Eno1 enolase 1 decreases expression ISO butylidenephthalide results in decreased expression of ENO1 protein CTD PMID:23770345 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO butylidenephthalide results in increased expression of ERN1 protein CTD PMID:23770345 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO butylidenephthalide results in increased expression of FAS protein CTD PMID:16987298, PMID:23770345 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fus FUS RNA binding protein increases expression ISO butylidenephthalide results in increased expression of FUS protein CTD PMID:23770345 NCBI chr 1:199,412,805...199,426,705
Ensembl chr 1:199,412,834...199,426,702
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO butylidenephthalide results in increased expression of GOT1 protein CTD PMID:23770345 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO butylidenephthalide results in decreased expression of HNRNPA3 protein CTD PMID:23770345 NCBI chr 3:62,481,222...62,491,356
Ensembl chr 3:62,481,323...62,487,227
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D increases expression ISO butylidenephthalide results in increased expression of HNRNPD protein CTD PMID:23770345 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO butylidenephthalide results in decreased expression of HNRNPF protein CTD PMID:23770345 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO butylidenephthalide results in decreased expression of HSP90AB1 protein CTD PMID:23770345 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO butylidenephthalide results in increased expression of HSPA5 protein CTD PMID:23770345 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO butylidenephthalide results in decreased expression of LDHA protein CTD PMID:23770345 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO butylidenephthalide results in increased expression of MIF protein CTD PMID:23770345 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO
EXP
butylidenephthalide results in decreased expression of MKI67 protein CTD PMID:16987298 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Ncl nucleolin decreases expression ISO butylidenephthalide results in decreased expression of NCL protein CTD PMID:23770345 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO butylidenephthalide results in increased expression of NME1 protein CTD PMID:23770345 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO butylidenephthalide results in decreased expression of PCNA protein CTD PMID:23770345 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression ISO butylidenephthalide results in decreased expression of PGK1 protein CTD PMID:23770345 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Phb prohibitin decreases expression ISO butylidenephthalide results in decreased expression of PHB protein CTD PMID:23770345 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO butylidenephthalide results in increased expression of PPP2R1A protein CTD PMID:23770345 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 decreases expression ISO butylidenephthalide results in decreased expression of PRPS1 protein CTD PMID:23770345 NCBI chr  X:111,798,233...111,820,270
Ensembl chr  X:111,798,233...111,820,266
JBrowse link
G Psma1 proteasome 20S subunit alpha 1 increases expression ISO butylidenephthalide results in increased expression of PSMA1 protein CTD PMID:23770345 NCBI chr 1:183,733,567...183,744,586
Ensembl chr 1:183,733,567...183,744,586
JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 decreases expression ISO butylidenephthalide results in decreased expression of PSMD11 protein CTD PMID:23770345 NCBI chr10:67,810,655...67,857,562
Ensembl chr10:67,810,655...67,857,223
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO
EXP
butylidenephthalide results in decreased phosphorylation of RB1 protein CTD PMID:16987298 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rpsa ribosomal protein SA decreases expression ISO butylidenephthalide results in decreased expression of RPSA protein CTD PMID:23770345 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 increases expression ISO butylidenephthalide results in increased expression of SF3B3 protein CTD PMID:23770345 NCBI chr19:43,392,071...43,429,582
Ensembl chr19:43,392,085...43,429,580
JBrowse link
G Sfn stratifin increases expression ISO butylidenephthalide results in increased expression of SFN protein CTD PMID:23770345 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
ISO butylidenephthalide results in increased expression of TP53 protein
butylidenephthalide results in increased phosphorylation of TP53 protein
CTD PMID:16987298 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO butylidenephthalide results in decreased expression of TPT1 protein CTD PMID:23770345 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial increases expression ISO butylidenephthalide results in increased expression of TUFM protein CTD PMID:23770345 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Was WASP actin nucleation promoting factor decreases expression ISO butylidenephthalide results in decreased expression of WAS protein CTD PMID:23770345 NCBI chr  X:15,155,246...15,164,099
Ensembl chr  X:15,155,230...15,164,105
JBrowse link
G Ybx1 Y box binding protein 1 decreases expression ISO butylidenephthalide results in decreased expression of YBX1 protein CTD PMID:23770345 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link
(Z)-ligustilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO ligustilide results in increased activity of AHR protein
[butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; ligustilide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of AKT1 protein CTD PMID:23973442 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO ligustilide results in decreased expression of APP protein CTD PMID:23973442 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ligustilide results in increased expression of BAX mRNA; ligustilide results in increased expression of BAX protein CTD PMID:31765699 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ligustilide results in decreased expression of BCL2 mRNA; ligustilide results in decreased expression of BCL2 protein CTD PMID:31765699 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO ligustilide results in increased activity of CASP3 protein
ligustilide results in increased cleavage of CASP3 protein
CTD PMID:30243965, PMID:31765699 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO ligustilide results in increased cleavage of CASP9 protein CTD PMID:31765699 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO ligustilide results in increased expression of and results in increased activity of CAT protein CTD PMID:23973442 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ligustilide results in increased expression of CCNB1 protein CTD PMID:31765699 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO ligustilide results in increased expression of CCND1 protein CTD PMID:31765699 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ligustilide results in increased expression of CDKN1A protein CTD PMID:31765699 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO ligustilide results in increased expression of CYCS protein CTD PMID:31765699 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO ligustilide results in increased expression of CYP1A1 mRNA
ligustilide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of FOXO1 protein CTD PMID:23973442 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ligustilide results in increased expression of HMOX1 mRNA; ligustilide results in increased expression of HMOX1 protein CTD PMID:23441843, PMID:30243965 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization EXP ligustilide affects the localization of HSF1 protein CTD PMID:26212861 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases phosphorylation ISO ligustilide results in decreased phosphorylation of IGF1R protein CTD PMID:23973442 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of IRS1 protein CTD PMID:23973442 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kl Klotho increases expression ISO ligustilide results in increased expression of KL mRNA; ligustilide results in increased expression of KL protein CTD PMID:23973442 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP ligustilide results in increased phosphorylation of MAPK1 protein CTD PMID:26212861 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP ligustilide results in increased phosphorylation of MAPK3 protein CTD PMID:26212861 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau decreases phosphorylation ISO ligustilide results in decreased phosphorylation of MAPT protein CTD PMID:23973442 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases methylation
affects response to substance
increases methylation
multiple interactions
ISO ligustilide results in decreased methylation of NFE2L2 promoter
NFE2L2 protein affects the susceptibility to ligustilide
ligustilide results in increased methylation of NFE2L2 promoter
ligustilide results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:23441843, PMID:30243965 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ligustilide results in increased expression of NQO1 mRNA; ligustilide results in increased expression of NQO1 protein CTD PMID:23441843, PMID:30243965 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO ligustilide results in increased activity of NR1I2 protein
[ligustilide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO ligustilide results in increased expression of and results in increased activity of SOD2 protein CTD PMID:23973442 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ligustilide results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31765699 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ligustilide results in increased expression of UGT1A1 protein
ligustilide results in increased expression of UGT1A1 mRNA
CTD PMID:23441843, PMID:30243965 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases export
multiple interactions
ISO ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]
CTD PMID:16156793 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh13 cadherin 13 affects response to substance ISO CDH13 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdyl2 chromodomain Y-like 2 affects response to substance ISO CDYL2 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr19:49,087,131...49,222,528
Ensembl chr19:49,093,355...49,198,073
JBrowse link
G Dner delta/notch-like EGF repeat containing affects response to substance ISO DNER gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Gna14 G protein subunit alpha 14 affects response to substance ISO GNA14 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr 1:235,165,775...235,347,986
Ensembl chr 1:235,166,718...235,347,937
JBrowse link
G Grip1 glutamate receptor interacting protein 1 affects response to substance ISO GRIP1 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr 7:64,672,723...64,854,939
Ensembl chr 7:64,672,722...64,864,404
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone results in increased mutagenesis of HPRT1 gene CTD PMID:17993254 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Mrtfb myocardin related transcription factor B affects response to substance ISO MRTFB gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr10:1,151,163...1,273,269 JBrowse link
G Plxna2 plexin A2 affects response to substance ISO PLXNA2 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone CTD PMID:25622337 NCBI chr13:113,373,569...113,570,774
Ensembl chr13:113,373,578...113,571,648
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis EXP 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone results in increased mutagenesis of TP53 gene CTD PMID:11152562 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
4-(ethoxymethylene)-2-phenyloxazol-5-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca6 ATP binding cassette subfamily A member 6 decreases expression ISO Oxazolone results in decreased expression of ABCA6 mRNA CTD PMID:17374397 NCBI chr10:98,477,716...98,546,699
Ensembl chr10:98,478,067...98,544,447
JBrowse link
G Abhd10 abhydrolase domain containing 10, depalmitoylase decreases expression ISO Oxazolone results in decreased expression of ABHD10 mRNA CTD PMID:17374397 NCBI chr11:60,053,719...60,068,142
Ensembl chr11:60,054,408...60,066,739
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 increases expression ISO Oxazolone results in increased expression of ADAMTS15 mRNA CTD PMID:19647056 NCBI chr 8:31,977,001...32,000,378
Ensembl chr 8:31,977,001...32,000,378
JBrowse link
G Adcy6 adenylate cyclase 6 decreases expression ISO Oxazolone results in decreased expression of ADCY6 mRNA CTD PMID:11379042 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adm adrenomedullin increases expression ISO Oxazolone results in increased expression of ADM mRNA CTD PMID:23999411 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akirin2 akirin 2 increases expression ISO Oxazolone results in increased expression of AKIRIN2 mRNA CTD PMID:23999411 NCBI chr 5:50,001,945...50,016,544
Ensembl chr 5:50,002,184...50,016,539
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity ISO Oxazolone results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression ISO Oxazolone results in increased expression of ANKRD2 mRNA CTD PMID:19647056 NCBI chr 1:261,281,859...261,291,307
Ensembl chr 1:261,281,543...261,291,394
JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases expression EXP Oxazolone results in increased expression of AOC1 mRNA CTD PMID:21893156 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Arg2 arginase 2 increases expression ISO Oxazolone results in increased expression of ARG2 mRNA CTD PMID:23999411 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arhgap17 Rho GTPase activating protein 17 decreases expression ISO Oxazolone results in decreased expression of ARHGAP17 mRNA CTD PMID:17374397 NCBI chr 1:193,239,036...193,328,425
Ensembl chr 1:193,239,040...193,328,371
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Oxazolone results in increased expression of ASNS mRNA CTD PMID:18242016 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf2 activating transcription factor 2 increases expression ISO Oxazolone results in increased expression of ATF2 mRNA CTD PMID:23999411 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Oxazolone results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Oxazolone results in increased expression of AXL mRNA CTD PMID:11379042 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Azin1 antizyme inhibitor 1 decreases expression ISO Oxazolone results in decreased expression of AZIN1 mRNA CTD PMID:17374397 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 increases expression ISO Oxazolone results in increased expression of BABAM2 mRNA CTD PMID:23999411 NCBI chr 6:25,666,654...26,135,888
Ensembl chr 6:25,666,655...26,051,229
JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO Oxazolone results in decreased expression of BCLAF1 mRNA CTD PMID:17374397 NCBI chr 1:15,799,753...15,828,838
Ensembl chr 1:15,782,477...15,860,624
JBrowse link
G Bmp1 bone morphogenetic protein 1 increases expression ISO Oxazolone results in increased expression of BMP1 mRNA CTD PMID:11379042 NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
JBrowse link
G Bmp7 bone morphogenetic protein 7 decreases expression ISO Oxazolone results in decreased expression of BMP7 mRNA CTD PMID:21404309 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Bpifa2 BPI fold containing family A, member 2 decreases expression ISO Oxazolone results in decreased expression of BPIFA2 mRNA CTD PMID:11379042 NCBI chr 3:149,492,612...149,501,614
Ensembl chr 3:149,493,655...149,501,613
JBrowse link
G Bspry B-box and SPRY domain containing increases expression ISO Oxazolone results in increased expression of BSPRY mRNA CTD PMID:18242016 NCBI chr 5:78,334,284...78,356,462
Ensembl chr 5:78,334,284...78,356,460
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression ISO Oxazolone results in increased expression of BST2 mRNA CTD PMID:19647056 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Oxazolone results in increased expression of BTG1 mRNA CTD PMID:17374397 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression
increases expression
ISO Oxazolone results in decreased expression of BUB1 mRNA
Oxazolone results in increased expression of BUB1 mRNA
CTD PMID:17374397, PMID:21404309 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression ISO Oxazolone results in increased expression of BUB1B mRNA CTD PMID:21404309 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 decreases expression ISO Oxazolone results in decreased expression of CACNB3 mRNA CTD PMID:11379042 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Car2 carbonic anhydrase 2 decreases expression ISO Oxazolone results in decreased expression of CA2 mRNA CTD PMID:17374397 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases activity EXP Oxazolone results in increased activity of CASP3 protein CTD PMID:24055189 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases expression ISO Oxazolone results in increased expression of CCL12 mRNA CTD PMID:19647056 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
increases expression
ISO Oxazolone results in decreased expression of CCL2 mRNA
Oxazolone results in increased expression of CCL2 mRNA
CTD PMID:15585374, PMID:17374397, PMID:19647056, PMID:21404309 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Oxazolone results in increased expression of CCL3 mRNA CTD PMID:15585374, PMID:19647056 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Oxazolone results in increased expression of CCL4 mRNA CTD PMID:15585374, PMID:19647056, PMID:21404309 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Oxazolone results in decreased expression of CCL5 mRNA CTD PMID:21404309 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression ISO Oxazolone results in increased expression of CCL6 mRNA CTD PMID:19647056, PMID:21404309 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP
ISO
Oxazolone results in increased expression of CCL7 mRNA CTD PMID:19647056, PMID:21404309, PMID:21893156 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Oxazolone results in increased expression of CCN1 mRNA CTD PMID:23999411 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Oxazolone results in increased expression of CCNA2 mRNA CTD PMID:21404309 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb2 cyclin B2 increases expression ISO Oxazolone results in increased expression of CCNB2 mRNA CTD PMID:21404309 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccne1 cyclin E1 increases expression ISO Oxazolone results in increased expression of CCNE1 mRNA CTD PMID:21404309 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccnf cyclin F increases expression ISO Oxazolone results in increased expression of CCNF mRNA CTD PMID:18242016 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Oxazolone results in increased expression of CCR1 mRNA CTD PMID:19647056 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression
increases expression
ISO Oxazolone results in decreased expression of CCR2 mRNA
Oxazolone results in increased expression of CCR2 mRNA
CTD PMID:17374397, PMID:19647056
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Oxazolone results in decreased expression of CCR6 mRNA CTD PMID:21404309 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO Oxazolone results in increased expression of CCR7 mRNA CTD PMID:17374397 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cd24 CD24 molecule decreases expression ISO Oxazolone results in decreased expression of CD24A mRNA CTD PMID:21404309 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd33 CD33 molecule decreases expression ISO Oxazolone results in decreased expression of CD33 mRNA CTD PMID:21404309 NCBI chr 1:98,388,811...98,403,539
Ensembl chr 1:98,398,660...98,402,968
JBrowse link
G Cd34 CD34 molecule decreases expression ISO Oxazolone results in decreased expression of CD34 mRNA CTD PMID:21404309 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd36 CD36 molecule decreases expression ISO Oxazolone results in decreased expression of CD36 mRNA CTD PMID:17374397, PMID:21404309 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40 CD40 molecule increases expression EXP Oxazolone results in increased expression of CD40 mRNA CTD PMID:21893156 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression ISO Oxazolone results in decreased expression of CD55 mRNA CTD PMID:21404309 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd86 CD86 molecule increases expression ISO Oxazolone results in increased expression of CD86 mRNA; Oxazolone results in increased expression of CD86 protein CTD PMID:17374397, PMID:24136171 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc20 cell division cycle 20 increases expression ISO Oxazolone results in increased expression of CDC20 mRNA CTD PMID:21404309 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Oxazolone results in increased expression of CDC25A mRNA CTD PMID:21404309 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25b cell division cycle 25B increases expression ISO Oxazolone results in increased expression of CDC25B mRNA CTD PMID:21404309 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Oxazolone results in increased expression of CDC25C mRNA CTD PMID:21404309 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc45 cell division cycle 45 increases expression ISO Oxazolone results in increased expression of CDC45 mRNA CTD PMID:21404309 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 increases expression ISO Oxazolone results in increased expression of CDC6 mRNA CTD PMID:21404309 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 increases expression ISO Oxazolone results in increased expression of CDC7 mRNA CTD PMID:21404309 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO Oxazolone results in increased expression of CDCA2 mRNA CTD PMID:18242016 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdh8 cadherin 8 decreases expression ISO Oxazolone results in decreased expression of CDH8 mRNA CTD PMID:17374397 NCBI chr19:6,031,654...6,431,502
Ensembl chr19:6,046,665...6,426,216
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Oxazolone results in increased expression of CDK1 mRNA CTD PMID:21404309 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Oxazolone results in increased expression of CDK2 mRNA CTD PMID:21404309 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkl4 cyclin-dependent kinase-like 4 increases expression ISO Oxazolone results in increased expression of CDKL4 mRNA CTD PMID:11379042 NCBI chr 6:3,232,278...3,272,454
Ensembl chr 6:3,234,090...3,254,779
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Oxazolone results in decreased expression of CDKN1C mRNA CTD PMID:21404309 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cerkl ceramide kinase-like decreases expression ISO Oxazolone results in decreased expression of CERKL mRNA CTD PMID:17374397 NCBI chr 3:66,268,835...66,395,615
Ensembl chr 3:66,268,947...66,394,764
JBrowse link
G Cidec cell death-inducing DFFA-like effector c increases expression ISO Oxazolone results in increased expression of CIDEC mRNA CTD PMID:17374397 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 decreases expression ISO Oxazolone results in decreased expression of CISD1 mRNA CTD PMID:17374397 NCBI chr20:18,493,538...18,506,923
Ensembl chr20:18,493,538...18,506,912
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 decreases expression ISO Oxazolone results in decreased expression of CMPK2 mRNA CTD PMID:17374397 NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
JBrowse link
G Cntf ciliary neurotrophic factor increases expression ISO Oxazolone results in increased expression of CNTF mRNA CTD PMID:21404309 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO Oxazolone results in increased expression of COMMD3 mRNA CTD PMID:21404309 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
JBrowse link
G Cpne3 copine 3 decreases expression ISO Oxazolone results in decreased expression of CPNE3 mRNA CTD PMID:17374397 NCBI chr 5:33,525,307...33,574,610
Ensembl chr 5:33,528,154...33,574,596
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Oxazolone results in increased expression of CREM mRNA CTD PMID:17374397 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Oxazolone results in increased expression of CSF2 mRNA CTD PMID:18652873 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Oxazolone results in increased expression of CSF2RB mRNA; Oxazolone results in increased expression of CSF2RB2 mRNA CTD PMID:19647056 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Csf3r colony stimulating factor 3 receptor increases expression ISO Oxazolone results in increased expression of CSF3R mRNA CTD PMID:19647056 NCBI chr 5:144,031,353...144,051,966
Ensembl chr 5:144,031,402...144,051,600
JBrowse link
G Ctsc cathepsin C decreases expression ISO Oxazolone results in decreased expression of CTSC mRNA CTD PMID:17374397 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 decreases expression ISO Oxazolone results in decreased expression of CX3CL1 mRNA CTD PMID:21404309 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
decreases expression
EXP
ISO
Oxazolone results in increased expression of CXCL10 mRNA
Oxazolone results in decreased expression of CXCL10 mRNA
CTD PMID:19647056, PMID:21404309, PMID:21893156, PMID:23445166 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression EXP Oxazolone results in increased expression of CXCL11 mRNA CTD PMID:21893156 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Oxazolone results in decreased expression of CXCL12 mRNA CTD PMID:21404309 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Oxazolone results in increased expression of CXCL14 mRNA CTD PMID:19647056 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 decreases expression ISO Oxazolone results in decreased expression of CXCL16 mRNA CTD PMID:21404309 NCBI chr10:57,060,005...57,064,600
Ensembl chr10:57,060,007...57,064,600
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Oxazolone results in increased expression of CXCL2 mRNA CTD PMID:19647056, PMID:24205293, PMID:28826779 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Oxazolone results in increased expression of CXCL1 mRNA CTD PMID:19647056, PMID:21404309, PMID:24205293, PMID:28826779 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression
increases expression
ISO
EXP
Oxazolone results in decreased expression of CXCL9 mRNA
Oxazolone results in increased expression of CXCL9 mRNA
CTD PMID:11379042, PMID:19647056, PMID:21404309, PMID:21893156, PMID:28826779 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Oxazolone results in increased expression of CXCR3 mRNA CTD PMID:21404309 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
increases expression
ISO Oxazolone results in decreased expression of CXCR4 mRNA
Oxazolone results in increased expression of CXCR4 mRNA
CTD PMID:11379042, PMID:17374397 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Oxazolone results in decreased expression of CYP2F2 mRNA CTD PMID:11379042 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cytip cytohesin 1 interacting protein increases expression ISO Oxazolone results in increased expression of CYTIP mRNA CTD PMID:17374397 NCBI chr 3:44,150,494...44,225,723
Ensembl chr 3:44,150,992...44,177,689
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 decreases expression ISO Oxazolone results in decreased expression of DACT1 mRNA CTD PMID:18242016 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dbf4 DBF4 zinc finger increases expression ISO Oxazolone results in increased expression of DBF4 mRNA CTD PMID:21404309 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dck deoxycytidine kinase increases expression ISO Oxazolone results in increased expression of DCK mRNA CTD PMID:21404309 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Dctpp1 dCTP pyrophosphatase 1 decreases expression ISO Oxazolone results in decreased expression of DCTPP1 mRNA CTD PMID:17374397 NCBI chr 1:198,703,459...198,706,852
Ensembl chr 1:198,703,461...198,706,852
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO Oxazolone results in increased expression of DHRS2 mRNA CTD PMID:23999411 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 decreases expression ISO Oxazolone results in decreased expression of DKC1 mRNA CTD PMID:17374397 NCBI chr  X:155,844,914...155,862,363
Ensembl chr  X:155,844,857...155,862,475
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO Oxazolone results in decreased expression of DLGAP5 mRNA CTD PMID:17374397 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Oxazolone results in increased expression of DNAJB4 mRNA CTD PMID:23999411 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 increases expression ISO Oxazolone results in increased expression of DNAJB6 mRNA CTD PMID:11379042, PMID:17374397 NCBI chr 4:2,711,329...2,774,969
Ensembl chr 4:2,711,385...2,774,890
JBrowse link
G Dntt DNA nucleotidylexotransferase decreases expression ISO Oxazolone results in decreased expression of DNTT mRNA CTD PMID:21404309 NCBI chr 1:260,289,626...260,321,174
Ensembl chr 1:260,289,589...260,321,320
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO Oxazolone results in decreased expression of DPYD mRNA CTD PMID:17374397, PMID:21404309 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dse dermatan sulfate epimerase decreases expression ISO Oxazolone results in decreased expression of DSE mRNA CTD PMID:17374397 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
G Dtymk deoxythymidylate kinase increases expression ISO Oxazolone results in increased expression of DTYMK mRNA CTD PMID:21404309 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO Oxazolone results in increased expression of DUSP4 mRNA CTD PMID:18242016 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Dut deoxyuridine triphosphatase increases expression ISO Oxazolone results in increased expression of DUT mRNA CTD PMID:18242016, PMID:21404309 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Oxazolone results in increased expression of E2F2 mRNA CTD PMID:21404309 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G Egr2 early growth response 2 decreases expression ISO Oxazolone results in decreased expression of EGR2 mRNA CTD PMID:17374397 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO Oxazolone results in increased expression of EHHADH mRNA CTD PMID:17374397 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Emb embigin decreases expression ISO Oxazolone results in decreased expression of EMB mRNA CTD PMID:17374397 NCBI chr 2:49,682,763...49,733,475
Ensembl chr 2:49,682,754...49,732,253
JBrowse link
G Eno3 enolase 3 increases expression ISO Oxazolone results in increased expression of ENO3 mRNA CTD PMID:11379042 NCBI chr10:57,278,271...57,283,661
Ensembl chr10:57,278,307...57,283,653
JBrowse link
G Epor erythropoietin receptor decreases expression ISO Oxazolone results in decreased expression of EPOR mRNA CTD PMID:21404309 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression ISO Oxazolone results in increased expression of ERCC6L mRNA CTD PMID:18242016 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099
JBrowse link
G F13a1 coagulation factor XIII A1 chain decreases expression ISO Oxazolone results in decreased expression of F13A1 mRNA CTD PMID:17374397 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression ISO Oxazolone results in increased expression of F2RL1 mRNA CTD PMID:23999411 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Oxazolone results in decreased expression of FABP1 mRNA CTD PMID:18242016 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fbxo9 f-box protein 9 decreases expression ISO Oxazolone results in decreased expression of FBXO9 mRNA CTD PMID:17374397 NCBI chr 8:85,388,331...85,413,896
Ensembl chr 8:85,388,333...85,413,484
JBrowse link
G Fcer2 Fc fragment of IgE receptor II decreases expression ISO Oxazolone results in decreased expression of FCER2A mRNA CTD PMID:21404309 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia increases expression ISO Oxazolone results in increased expression of FCGR1 mRNA CTD PMID:21404309 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression ISO Oxazolone results in increased expression of FCGR2B mRNA CTD PMID:17374397 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression ISO Oxazolone results in increased expression of FFAR2 mRNA CTD PMID:18242016 NCBI chr 1:89,268,197...89,271,942
Ensembl chr 1:89,268,938...89,269,930
JBrowse link
G Fgl2 fibrinogen-like 2 decreases expression ISO Oxazolone results in decreased expression of FGL2 mRNA CTD PMID:17374397 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 decreases expression EXP Oxazolone results in decreased expression of FMO2 mRNA CTD PMID:21893156 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Oxazolone results in increased expression of FOSB mRNA CTD PMID:23999411 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Oxazolone results in increased expression of GADD45B mRNA CTD PMID:11379042 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Oxazolone results in increased expression of GBP2 mRNA CTD PMID:21893156 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Oxazolone results in increased expression of GCLM mRNA CTD PMID:23999411 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO Oxazolone results in increased expression of GGT1 mRNA CTD PMID:21404309 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 decreases expression ISO Oxazolone results in decreased expression of GGT5 mRNA CTD PMID:21404309 NCBI chr20:13,988,444...14,001,296 JBrowse link
G Grap2 GRB2-related adaptor protein 2 increases expression ISO Oxazolone results in increased expression of GRAP2 mRNA CTD PMID:21404309 NCBI chr 7:121,791,330...121,864,835
Ensembl chr 7:121,841,855...121,864,679
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Oxazolone results in decreased expression of GSTM1 mRNA CTD PMID:21404309 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Oxazolone results in decreased expression of GSTM3 mRNA CTD PMID:21404309 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gtf2b general transcription factor IIB increases expression ISO Oxazolone results in increased expression of GTF2B mRNA CTD PMID:17374397 NCBI chr 2:248,709,433...248,727,741
Ensembl chr 2:248,715,281...248,727,741
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression EXP Oxazolone results in decreased expression of GULP1 mRNA CTD PMID:21893156 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G Gzma granzyme A increases expression ISO Oxazolone results in increased expression of GZMA mRNA CTD PMID:18242016 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
G Gzmb granzyme B decreases expression
increases expression
ISO
EXP
Oxazolone results in decreased expression of GZMB mRNA
Oxazolone results in increased expression of GZMB mRNA
CTD PMID:11379042, PMID:18652873, PMID:21893156 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Gzmm granzyme M increases expression EXP Oxazolone results in increased expression of GZMM mRNA CTD PMID:21893156 NCBI chr 7:12,893,431...12,899,004
Ensembl chr 7:12,893,432...12,899,004
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions
increases secretion
ISO cupressuflavone inhibits the reaction [Oxazolone results in increased secretion of HEXB protein] CTD PMID:29258854 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Oxazolone results in increased expression of HMOX1 mRNA CTD PMID:26244607 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO Oxazolone results in decreased expression of HNRNPA3 mRNA CTD PMID:17374397 NCBI chr 3:62,481,222...62,491,356
Ensembl chr 3:62,481,323...62,487,227
JBrowse link
G Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 increases expression ISO Oxazolone results in increased expression of HNRNPH3 mRNA CTD PMID:11379042 NCBI chr20:27,167,926...27,178,172
Ensembl chr20:27,169,267...27,216,941
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Oxazolone results in increased expression of HNRNPLL mRNA CTD PMID:21404309, PMID:23999411 NCBI chr 6:2,698,983...2,729,715
Ensembl chr 6:2,699,961...2,729,394
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Oxazolone results in increased expression of HSPA4 mRNA CTD PMID:11379042 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Oxazolone results in decreased expression of IDI1 mRNA CTD PMID:17374397 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Oxazolone results in increased expression of IER3 mRNA CTD PMID:17374397 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO Oxazolone results in increased expression of IFI27 mRNA CTD PMID:18242016 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Oxazolone results in increased expression of IFI44L mRNA CTD PMID:18242016 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 decreases expression ISO Oxazolone results in decreased expression of IFIT2 mRNA CTD PMID:17374397 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression EXP Oxazolone results in increased expression of IFIT3 mRNA CTD PMID:21893156 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO Oxazolone results in increased expression of IFNG mRNA; Oxazolone results in increased expression of IFNG protein
12-acetoxyhawtriwaic acid lactone inhibits the reaction [Oxazolone results in increased expression of IFNG protein]; centipedic acid inhibits the reaction [Oxazolone results in increased expression of IFNG protein]; Dexamethasone inhibits the reaction [Oxazolone results in increased expression of IFNG protein]
CTD PMID:18242016, PMID:18652873, PMID:18670081, PMID:19422874, PMID:21404309, PMID:24205293, PMID:28826779 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr2 interferon gamma receptor 2 decreases expression ISO Oxazolone results in decreased expression of IFNGR2 mRNA CTD PMID:21404309 NCBI chr11:31,694,339...31,712,611
Ensembl chr11:31,694,339...31,712,611
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Oxazolone results in increased expression of IFRD1 mRNA CTD PMID:17374397 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression ISO Oxazolone results in increased expression of IGFBP6 mRNA CTD PMID:17374397 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054
JBrowse link
G Il10 interleukin 10 increases expression ISO Oxazolone results in increased expression of IL10 protein CTD PMID:19422874 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO Oxazolone results in increased expression of IL10RA mRNA CTD PMID:19647056 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il11 interleukin 11 increases expression ISO Oxazolone results in increased expression of IL11 mRNA CTD PMID:19647056 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 decreases expression ISO Oxazolone results in decreased expression of IL11RA1 mRNA CTD PMID:21404309 NCBI chr 5:58,149,150...58,159,072
Ensembl chr 5:58,151,985...58,159,072
JBrowse link
G Il12b interleukin 12B increases expression ISO Oxazolone results in increased expression of IL12B mRNA; Oxazolone results in increased expression of IL12B protein CTD PMID:11379042, PMID:11708898, PMID:18652873 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression ISO Oxazolone results in increased expression of IL12RB1 mRNA CTD PMID:18242016, PMID:21404309 NCBI chr16:20,370,722...20,383,576
Ensembl chr16:20,371,338...20,383,337
JBrowse link
G Il15 interleukin 15 increases expression ISO Oxazolone results in increased expression of IL15 mRNA CTD PMID:11379042 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il18 interleukin 18 increases expression ISO Oxazolone results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il19 interleukin 19 increases expression ISO Oxazolone results in increased expression of IL19 mRNA CTD PMID:19647056 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
affects secretion
ISO Clofibrate inhibits the reaction [Oxazolone results in increased expression of IL1A protein]
Oxazolone results in increased expression of IL1A mRNA
Oxazolone affects the secretion of IL1A protein
CTD PMID:11851881, PMID:12781210, PMID:18652873 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
increases expression
ISO Oxazolone results in decreased expression of IL1B mRNA
ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; SSTR4 gene mutant form promotes the reaction [Oxazolone results in increased expression of IL1B protein]
Oxazolone results in increased expression of IL1B mRNA; Oxazolone results in increased expression of IL1B protein
CTD PMID:11379042, PMID:16557482, PMID:18652873, PMID:18710581, PMID:19622729, PMID:19647056, PMID:21404309, PMID:24205293 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression ISO Oxazolone results in increased expression of IL2 mRNA; Oxazolone results in increased expression of IL2 protein CTD PMID:11379042, PMID:18652873 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il24 interleukin 24 increases expression ISO Oxazolone results in increased expression of IL24 mRNA CTD PMID:19647056 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression ISO Oxazolone results in increased expression of IL2RA mRNA CTD PMID:21404309 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO Oxazolone results in increased expression of IL2RB mRNA CTD PMID:21404309 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Il3 interleukin 3 decreases expression
increases expression
ISO Oxazolone results in decreased expression of IL3 mRNA
Oxazolone results in increased expression of IL3 mRNA
CTD PMID:11379042, PMID:18652873 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
increases secretion
ISO Oxazolone results in increased expression of IL4 mRNA; Oxazolone results in increased expression of IL4 protein
cupressuflavone inhibits the reaction [Oxazolone results in increased secretion of IL4 protein]
CTD PMID:11708898, PMID:18652873, PMID:19422874, PMID:28826779, PMID:29258854 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO Oxazolone results in increased expression of IL4RA mRNA CTD PMID:19647056 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
ISO Oxazolone results in increased secretion of IL6 protein
Oxazolone results in increased expression of IL6 mRNA; Oxazolone results in increased expression of IL6 protein
CTD PMID:17763283, PMID:18652873, PMID:19647056, PMID:24205293 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il7 interleukin 7 decreases expression
increases expression
ISO Oxazolone results in decreased expression of IL7 mRNA
Oxazolone results in increased expression of IL7 mRNA
CTD PMID:11379042, PMID:18242016, PMID:21404309 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Il7r interleukin 7 receptor decreases expression ISO Oxazolone results in decreased expression of IL7R mRNA CTD PMID:21404309
G Inhba inhibin subunit beta A increases expression ISO Oxazolone results in increased expression of INHBA mRNA CTD PMID:19647056 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression EXP Oxazolone results in increased expression of IRF1 mRNA CTD PMID:21893156 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 increases expression ISO Oxazolone results in increased expression of IRF2BP2 mRNA CTD PMID:23999411 NCBI chr19:59,497,021...59,502,298
Ensembl chr19:59,499,876...59,502,161
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Oxazolone results in increased expression of IRF7 mRNA CTD PMID:21893156 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irgm immunity-related GTPase M increases expression EXP Oxazolone results in increased expression of IRGM mRNA CTD PMID:21893156 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression
increases expression
ISO
EXP
Oxazolone results in decreased expression of ISG15 mRNA
Oxazolone results in increased expression of ISG15 mRNA
CTD PMID:11379042, PMID:21893156 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 decreases expression ISO Oxazolone results in decreased expression of KCNJ2 mRNA CTD PMID:17374397 NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114
JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO Oxazolone results in decreased expression of KIF23 mRNA CTD PMID:17374397 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kitlg KIT ligand decreases expression ISO Oxazolone results in decreased expression of KITL mRNA CTD PMID:21404309 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klf10 Kruppel-like factor 10 increases expression ISO Oxazolone results in increased expression of KLF10 mRNA CTD PMID:23999411 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression ISO Oxazolone results in increased expression of KLF6 mRNA CTD PMID:17374397, PMID:23999411 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Lig1 DNA ligase 1 increases expression ISO Oxazolone results in increased expression of LIG1 mRNA CTD PMID:21404309 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758
JBrowse link
G LOC103694381 lymphotoxin-beta increases expression ISO Oxazolone results in increased expression of LTB mRNA CTD PMID:19647056 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Oxazolone results in increased expression of MAFF mRNA CTD PMID:23999411 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Oxazolone results in increased expression of MAFK mRNA CTD PMID:17374397 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression ISO Oxazolone results in increased expression of MCM2 mRNA CTD PMID:21404309 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Oxazolone results in increased expression of MCM3 mRNA CTD PMID:21404309 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO Oxazolone results in increased expression of MCM4 mRNA CTD PMID:21404309 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression ISO Oxazolone results in increased expression of MCM5 mRNA CTD PMID:21404309 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression ISO Oxazolone results in increased expression of MCM6 mRNA CTD PMID:21404309 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 increases expression ISO Oxazolone results in increased expression of MCM7 mRNA CTD PMID:21404309 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mcts1 MCTS1, re-initiation and release factor decreases expression ISO Oxazolone results in decreased expression of MCTS1 mRNA CTD PMID:17374397 NCBI chr  X:124,894,269...124,906,129
Ensembl chr  X:124,894,466...124,906,162
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Oxazolone results in decreased expression of MGST2 mRNA CTD PMID:21404309 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mpo myeloperoxidase decreases expression
multiple interactions
increases activity
increases expression
ISO
EXP
Oxazolone results in decreased expression of MPO mRNA
resveratrol inhibits the reaction [Oxazolone results in increased activity of MPO protein]
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of MPO protein]
CTD PMID:17374397, PMID:22200888, PMID:24055189 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrpl35 mitochondrial ribosomal protein L35 decreases expression ISO Oxazolone results in decreased expression of MRPL35 mRNA CTD PMID:17374397 NCBI chr 4:99,738,792...99,749,665
Ensembl chr 4:99,738,792...99,746,560
JBrowse link
G Mrps6 mitochondrial ribosomal protein S6 decreases expression ISO Oxazolone results in decreased expression of MRPS6 mRNA CTD PMID:17374397 NCBI chr11:32,208,246...32,263,999
Ensembl chr11:32,211,115...32,263,899
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Oxazolone results in decreased expression of MYB mRNA CTD PMID:17374397 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Oxazolone results in decreased expression of MYC mRNA CTD PMID:17374397 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Oxazolone results in increased expression of NAMPT mRNA CTD PMID:17374397 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO Oxazolone results in decreased expression of NFKB1 mRNA CTD PMID:11379042 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Oxazolone results in increased expression of NINJ1 mRNA CTD PMID:17374397 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327
JBrowse link
G Nkg7 natural killer cell granule protein 7 increases expression EXP Oxazolone results in increased expression of NKG7 mRNA CTD PMID:21893156 NCBI chr 1:98,492,873...98,493,940
Ensembl chr 1:98,492,828...98,493,978
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Oxazolone results in increased expression of NOS2 mRNA
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of NOS2 mRNA]
CTD PMID:22200888 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Oxazolone results in increased expression of NR3C1 mRNA CTD PMID:17374397 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO Oxazolone results in decreased expression of NREP mRNA CTD PMID:17374397 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Nudt19 nudix hydrolase 19 increases expression ISO Oxazolone results in increased expression of NUDT19 mRNA CTD PMID:11379042 NCBI chr 1:91,820,317...91,845,215
Ensembl chr 1:91,820,342...91,832,058
JBrowse link
G Nup155 nucleoporin 155 increases expression EXP Oxazolone results in increased expression of NUP155 mRNA CTD PMID:21893156 NCBI chr 2:57,206,665...57,258,242
Ensembl chr 2:57,206,613...57,258,295
JBrowse link
G Nup88 nucleoporin 88 increases expression ISO Oxazolone results in increased expression of NUP88 mRNA CTD PMID:17374397 NCBI chr10:57,581,828...57,606,171
Ensembl chr10:57,581,828...57,606,171
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP Oxazolone results in increased expression of OASL mRNA CTD PMID:21893156 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Oxazolone results in increased expression of ODC1 mRNA CTD PMID:21404309 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO Oxazolone results in increased expression of ORC1 mRNA CTD PMID:21404309 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Orc6 origin recognition complex, subunit 6 increases expression ISO Oxazolone results in increased expression of ORC6 mRNA CTD PMID:21404309 NCBI chr19:27,457,541...27,464,804
Ensembl chr19:27,457,474...27,464,805
JBrowse link
G Osm oncostatin M increases expression ISO Oxazolone results in increased expression of OSM mRNA CTD PMID:19647056 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Otud1 OTU deubiquitinase 1 increases expression ISO Oxazolone results in increased expression of OTUD1 mRNA CTD PMID:17374397 NCBI chr17:86,406,643...86,410,670
Ensembl chr17:86,408,151...86,409,518
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase decreases expression ISO Oxazolone results in decreased expression of PAICS mRNA CTD PMID:17374397 NCBI chr14:33,563,884...33,580,944
Ensembl chr14:33,563,886...33,580,566
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases expression ISO Oxazolone results in increased expression of PAK2 mRNA CTD PMID:23999411 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 increases expression EXP Oxazolone results in increased expression of PARP14 mRNA CTD PMID:21893156 NCBI chr11:68,105,442...68,137,509
Ensembl chr11:68,105,369...68,137,535
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Oxazolone results in increased expression of PCNA mRNA CTD PMID:21404309 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pde4d phosphodiesterase 4D increases expression ISO Oxazolone results in increased expression of PDE4D mRNA CTD PMID:17374397 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO Oxazolone results in increased expression of PEG10 mRNA CTD PMID:23999411 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pf4 platelet factor 4 increases expression ISO Oxazolone results in increased expression of PF4 mRNA CTD PMID:19647056 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Phf11 PHD finger protein 11 increases expression ISO Oxazolone results in increased expression of PHF11 mRNA CTD PMID:19647056 NCBI chr15:38,692,817...39,683,417
Ensembl chr15:38,647,779...38,709,984
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO Oxazolone results in increased expression of PHLDA1 mRNA CTD PMID:17374397 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 increases expression ISO Oxazolone results in increased expression of PKMYT1 mRNA CTD PMID:21404309 NCBI chr10:13,061,077...13,072,277
Ensembl chr10:13,061,170...13,073,283
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Oxazolone results in increased expression of PLAT mRNA CTD PMID:17374397 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plk1 polo-like kinase 1 increases expression ISO Oxazolone results in increased expression of PLK1 mRNA CTD PMID:21404309 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Oxazolone results in increased expression of PMAIP1 mRNA CTD PMID:23999411 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO Oxazolone results in increased expression of POLA1 mRNA CTD PMID:21404309 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit increases expression ISO Oxazolone results in increased expression of POLA2 mRNA CTD PMID:21404309 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit increases expression ISO Oxazolone results in increased expression of POLD3 mRNA CTD PMID:21404309 NCBI chr 1:165,085,142...165,122,385
Ensembl chr 1:165,083,622...165,123,455
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO Oxazolone results in increased expression of POLE mRNA CTD PMID:21404309 NCBI chr12:52,403,533...52,452,075
Ensembl chr12:52,403,529...52,452,040
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit increases expression ISO Oxazolone results in increased expression of POLE2 mRNA CTD PMID:21404309 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996
JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit increases expression ISO Oxazolone results in increased expression of POLE3 mRNA CTD PMID:21404309 NCBI chr 5:78,380,813...78,384,047
Ensembl chr 5:78,380,816...78,384,047
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases expression ISO Oxazolone results in increased expression of PPA1 mRNA CTD PMID:18242016 NCBI chr20:31,265,519...31,292,451
Ensembl chr20:31,265,483...31,310,674
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Oxazolone results in increased expression of PPARG protein
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PPARG protein]
CTD PMID:22200888 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppbp pro-platelet basic protein increases expression ISO Oxazolone results in increased expression of PPBP mRNA CTD PMID:19647056 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha decreases expression ISO Oxazolone results in decreased expression of PPP2R3A mRNA CTD PMID:11379042 NCBI chr 8:109,481,352...109,621,462
Ensembl chr 8:109,482,614...109,621,408
JBrowse link
G Prim1 DNA primase subunit 1 increases expression ISO Oxazolone results in increased expression of PRIM1 mRNA CTD PMID:21404309 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 decreases expression ISO Oxazolone results in decreased expression of PSMA5 mRNA CTD PMID:17374397 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression EXP Oxazolone results in increased expression of PSMB10 mRNA CTD PMID:21893156 NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 increases expression EXP Oxazolone results in increased expression of PSMB8 mRNA CTD PMID:21893156 NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP Oxazolone results in increased expression of PSMB9 mRNA CTD PMID:21893156 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO Oxazolone results in increased expression of PSME4 mRNA CTD PMID:21404309 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO Oxazolone results in decreased expression of PTGER3 mRNA CTD PMID:17374397 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA] CTD PMID:16557482, PMID:22200888 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO Oxazolone results in increased expression of PTP4A1 mRNA CTD PMID:23999411 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Oxazolone results in increased expression of PTTG1 mRNA CTD PMID:21404309 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rab20 RAB20, member RAS oncogene family increases expression EXP Oxazolone results in increased expression of RAB20 mRNA CTD PMID:21893156 NCBI chr16:83,358,116...83,382,326
Ensembl chr16:83,358,116...83,382,326
JBrowse link
G Rab32 RAB32, member RAS oncogene family decreases expression ISO Oxazolone results in decreased expression of RAB32 mRNA CTD PMID:17374397 NCBI chr 1:4,638,663...4,653,220
Ensembl chr 1:4,637,491...4,653,210
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO Oxazolone results in increased expression of RBL1 mRNA CTD PMID:11379042 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases expression ISO Oxazolone results in decreased expression of RBM17 mRNA CTD PMID:17374397 NCBI chr17:70,586,345...70,603,289
Ensembl chr17:70,586,394...70,603,267
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region decreases expression ISO Oxazolone results in decreased expression of RBPJ mRNA CTD PMID:17374397 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Rcc1 regulator of chromosome condensation 1 increases expression ISO Oxazolone results in increased expression of RCC1 mRNA CTD PMID:18242016 NCBI chr 5:150,508,840...150,531,062
Ensembl chr 5:150,509,040...150,525,254
JBrowse link
G Rcn1 reticulocalbin 1 increases expression ISO Oxazolone results in increased expression of RCN1 mRNA CTD PMID:11379042 NCBI chr 3:95,404,863...95,419,110
Ensembl chr 3:95,406,284...95,418,679
JBrowse link
G Recql4 RecQ like helicase 4 increases expression ISO Oxazolone results in increased expression of RECQL4 mRNA CTD PMID:18242016 NCBI chr 7:117,765,892...117,773,128
Ensembl chr 7:117,763,783...117,773,134
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
ISO Oxazolone results in increased expression of RELA mRNA
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of RELA mRNA]
CTD PMID:22200888 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rfc3 replication factor C subunit 3 increases expression ISO Oxazolone results in increased expression of RFC3 mRNA CTD PMID:21404309 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO Oxazolone results in increased expression of RFC4 mRNA CTD PMID:21404309 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043
JBrowse link
G Rfc5 replication factor C subunit 5 increases expression ISO Oxazolone results in increased expression of RFC5 mRNA CTD PMID:21404309 NCBI chr12:44,931,494...44,941,051
Ensembl chr12:44,931,494...44,941,324
JBrowse link
G RGD1309362 similar to interferon-inducible GTPase increases expression EXP Oxazolone results in increased expression of RGD1309362 mRNA CTD PMID:21893156 NCBI chr18:55,483,059...55,508,714
Ensembl chr18:55,505,993...55,508,704
JBrowse link
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed decreases expression ISO Oxazolone results in decreased expression of C12ORF4 mRNA CTD PMID:17374397 NCBI chr 4:159,483,089...159,518,387
Ensembl chr 4:159,483,131...159,515,447
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Oxazolone results in increased expression of RGS1 mRNA CTD PMID:17374397 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
JBrowse link
G Rlim ring finger protein, LIM domain interacting increases expression ISO Oxazolone results in increased expression of RLIM mRNA CTD PMID:23999411 NCBI chr  X:73,757,664...73,778,763
Ensembl chr  X:73,762,691...73,778,674
Ensembl chr  X:73,762,691...73,778,674
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Oxazolone results in decreased expression of RNASE2A mRNA CTD PMID:18242016 NCBI chr15:28,154,482...28,155,291
Ensembl chr15:28,154,482...28,155,291
JBrowse link
G Rnaseh2b ribonuclease H2, subunit B increases expression ISO Oxazolone results in increased expression of RNASEH2B mRNA CTD PMID:21404309 NCBI chr15:45,422,010...45,472,792
Ensembl chr15:45,422,010...45,464,892
JBrowse link
G Rpl27a ribosomal protein L27a increases expression ISO Oxazolone results in increased expression of RPL27A mRNA CTD PMID:17374397 NCBI chr 1:174,132,798...174,135,816
Ensembl chr 1:174,132,798...174,135,816
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression ISO Oxazolone results in increased expression of RRM1 mRNA CTD PMID:21404309 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO Oxazolone results in increased expression of RRM2 mRNA CTD PMID:21404309 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 increases expression EXP
ISO
Oxazolone results in increased expression of RTP4 mRNA CTD PMID:18242016, PMID:19647056, PMID:21893156 NCBI chr11:80,638,945...80,650,802
Ensembl chr11:80,638,945...80,650,802
JBrowse link
G Runx3 RUNX family transcription factor 3 increases expression EXP Oxazolone results in increased expression of RUNX3 mRNA CTD PMID:21893156 NCBI chr 5:153,507,093...153,531,137