ophthalmology drug - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ophthalmology drug	go back to main search page
Accession:	CHEBI:66981	browse the term
Definition:	Any compound used for the treatment of eye conditions or eye diseases.
Synonyms:	related_synonym:	ophthalmic; ophthalmic agent; ophthalmic agents; ophthalmics; ophthalmological; ophthalmologicals; ophthalmology agent; ophthalmology agents; ophthalmology drugs

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Rat (437) Mouse (445) Human (439) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (437)

(+)-pilocarpine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Pilocarpine results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

affects expression
increases expression

Pilocarpine affects the expression of ABCB1A mRNA
Pilocarpine results in increased expression of ABCB1A mRNA; Pilocarpine results in increased expression of ABCB1A protein

PMID:14706787 PMID:17437408 PMID:19055492

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects expression
increases expression

Pilocarpine affects the expression of ABCB1B mRNA
Pilocarpine results in increased expression of ABCB1B mRNA; Pilocarpine results in increased expression of ABCB1B protein

PMID:14706787 PMID:19055492 PMID:19570321

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

affects expression

Pilocarpine affects the expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression

Pilocarpine results in increased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 5

affects expression

Pilocarpine affects the expression of ABCC5 mRNA

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

angiotensin I converting enzyme

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

decreases activity
multiple interactions
increases expression
decreases expression

Pilocarpine results in decreased activity of ACHE protein
garcinielliptone FC inhibits the reaction [Pilocarpine results in decreased activity of ACHE protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]; [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
Pilocarpine results in increased expression of ACHE mRNA alternative form; Pilocarpine results in increased expression of ACHE protein alternative form

PMID:16481111 PMID:18242586 PMID:18333967 PMID:19669875 PMID:19932735 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

actin, beta

multiple interactions

Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

adenosine A1 receptor

multiple interactions

[2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

affects response to substance

ADORA2A protein affects the susceptibility to Pilocarpine

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 1B

increases response to substance

ADRA1B protein results in increased susceptibility to Pilocarpine

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

agrin

increases expression

Pilocarpine results in increased expression of AGRN protein

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

angiotensin II receptor, type 1a

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A protein]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

multiple interactions

[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of AGTR2 mRNA

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

allograft inflammatory factor 1

increases expression

Pilocarpine results in increased expression of AIF1 protein

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

A-kinase anchoring protein 5

increases response to substance

AKAP5 protein mutant form results in increased susceptibility to Pilocarpine

NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

Pilocarpine results in decreased phosphorylation of AKT1 protein
1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Pilocarpine results in decreased phosphorylation of AKT1 protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased phosphorylation of AKT1 protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Pilocarpine results in decreased phosphorylation of AKT1 protein]]

PMID:19429016 PMID:30542433 PMID:31018114

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

decreases expression
decreases activity
multiple interactions

Pilocarpine results in decreased expression of ALAD protein
Pilocarpine results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]
Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]; Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]

PMID:19798568 PMID:20026167 PMID:20584200 PMID:25490531

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

ankyrin 3

increases expression

Pilocarpine results in increased expression of ANK3 mRNA; Pilocarpine results in increased expression of ANK3 protein

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression
affects localization
decreases expression

Pilocarpine results in increased expression of APEX1 mRNA
Pilocarpine affects the localization of APEX1 mRNA
Pilocarpine results in decreased expression of APEX1 protein

PMID:17971868 PMID:20206232 PMID:20446108

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

amyloid beta precursor like protein 1

decreases expression

Pilocarpine results in decreased expression of APLP1 mRNA

NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155

G

aquaporin 4

decreases expression

Pilocarpine results in decreased expression of AQP4 protein

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 5

multiple interactions
affects localization

Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein]

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

acid sensing ion channel subunit 1

decreases expression

Pilocarpine results in decreased expression of ASIC1 mRNA

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

G

acid sensing ion channel subunit 2

decreases expression

Pilocarpine results in decreased expression of ASIC2 mRNA alternative form

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

G

activating transcription factor 2

multiple interactions
increases expression

[Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein
Pilocarpine results in increased expression of ATF2 mRNA

PMID:17971868 PMID:19430551

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

Pilocarpine results in increased expression of ATP2A2 protein

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATRX, chromatin remodeler

increases expression

Pilocarpine results in increased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

Pilocarpine results in decreased expression of BAX mRNA
Pilocarpine results in increased expression of BAX mRNA; Pilocarpine results in increased expression of BAX protein

PMID:14754538 PMID:17971868 PMID:19429016

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

[Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL10, immune signaling adaptor

decreases expression
increases expression

Pilocarpine results in decreased expression of BCL10 mRNA
Pilocarpine results in increased expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

decreases expression

Pilocarpine results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

Pilocarpine results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

bradykinin receptor B1

decreases response to substance

BDKRB1 protein mutant form results in decreased susceptibility to Pilocarpine

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

increases response to substance

BDKRB2 protein mutant form results in increased susceptibility to Pilocarpine

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

increases expression
decreases expression
multiple interactions

Pilocarpine results in increased expression of BDNF protein modified form
Pilocarpine results in increased expression of BDNF exon; Pilocarpine results in increased expression of BDNF mRNA; Pilocarpine results in increased expression of BDNF mRNA alternative form; Pilocarpine results in increased expression of BDNF protein
Pilocarpine results in decreased expression of BDNF protein
1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 1 alpha,24-dihydroxyvitamin D3 promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA alternative form]; [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA; Pilocarpine results in increased expression of and results in increased localization of BDNF protein; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]

PMID:8405262 PMID:8635431 PMID:8821376 PMID:9015327 PMID:9073163 More...

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions
increases expression

Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]; Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]
Pilocarpine results in increased expression of BECN1 mRNA; Pilocarpine results in increased expression of BECN1 protein

PMID:17971868 PMID:19138675

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone morphogenetic protein 4

decreases expression
increases expression

Pilocarpine results in decreased expression of BMP4 mRNA
Pilocarpine results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BCL2 interacting protein 1

increases expression

Pilocarpine results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 3

increases expression

Pilocarpine results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

calcium voltage-gated channel subunit alpha1 A

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1A protein
Pilocarpine results in increased expression of CACNA1A protein

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 B

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1B mRNA; Pilocarpine results in decreased expression of CACNA1B protein
Pilocarpine results in increased expression of CACNA1B protein

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel subunit alpha1 C

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1C protein
Pilocarpine results in increased expression of CACNA1C protein

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

G

calcium voltage-gated channel subunit alpha1 D

decreases expression
increases expression

Pilocarpine results in decreased expression of CACNA1D protein
Pilocarpine results in increased expression of CACNA1D protein

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

G

caspase 12

multiple interactions

[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage
increases activity
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
[Pilocarpine co-treated with Lithium] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Pilocarpine results in increased cleavage of and results in increased activity of CASP3 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Pilocarpine results in increased expression of CASP3 protein modified form

PMID:12097334 PMID:18708038 PMID:18815271 PMID:19429016 PMID:19631748 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

multiple interactions

Pilocarpine results in increased cleavage of and results in increased activity of CASP6 protein

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 9

increases expression

Pilocarpine results in increased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
increases expression
multiple interactions

Pilocarpine results in increased activity of CAT protein
Pilocarpine results in increased expression of CAT protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]; Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]

PMID:15245787 PMID:15752349 PMID:16115668 PMID:17205390 PMID:17383094 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression
decreases expression

Pilocarpine results in increased expression of CCL2 mRNA; Pilocarpine results in increased expression of CCL2 protein
Pilocarpine results in decreased expression of CCL2 protein

PMID:15193289 PMID:17971868 PMID:19490431 PMID:20034406

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

decreases expression
increases expression

Pilocarpine results in decreased expression of CCL3 protein
Pilocarpine results in increased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine receptor 10

decreases expression

Pilocarpine results in decreased expression of CCR10 mRNA; Pilocarpine results in decreased expression of CCR10 protein

NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988

G

C-C motif chemokine receptor 2

increases expression
decreases expression

Pilocarpine results in increased expression of CCR2 protein
Pilocarpine results in decreased expression of CCR2 mRNA; Pilocarpine results in decreased expression of CCR2 protein

PMID:19490431 PMID:20034406

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 3

decreases expression

Pilocarpine results in decreased expression of CCR3 mRNA; Pilocarpine results in decreased expression of CCR3 protein

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 7

decreases expression

Pilocarpine results in decreased expression of CCR7 mRNA; Pilocarpine results in decreased expression of CCR7 protein

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor 8

decreases expression

Pilocarpine results in decreased expression of CCR8 mRNA; Pilocarpine results in decreased expression of CCR8 protein

NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629

G

C-C motif chemokine receptor 9

decreases expression

Pilocarpine results in decreased expression of CCR9 mRNA; Pilocarpine results in decreased expression of CCR9 protein

NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969

G

CD40 molecule

increases expression
multiple interactions

Pilocarpine results in increased expression of CD40 protein
rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

increases expression

Pilocarpine results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cadherin 1

decreases expression
increases expression

Pilocarpine results in decreased expression of CDH1 protein
Pilocarpine results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

increases expression

Pilocarpine results in increased expression of CDH2 mRNA; Pilocarpine results in increased expression of CDH2 protein

PMID:12125071 PMID:12387456

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

increases expression

Pilocarpine results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

increases expression

Pilocarpine results in increased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1B

increases expression

Pilocarpine results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

decreases expression
increases expression

Pilocarpine results in decreased expression of CDKN2A mRNA
Pilocarpine results in increased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein alpha

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of CEBPA mRNA]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

choline O-acetyltransferase

decreases activity
multiple interactions
decreases expression

Pilocarpine results in decreased activity of CHAT protein
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein
Pilocarpine results in decreased expression of CHAT protein

PMID:19669875 PMID:19932735 PMID:19941057

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cholinergic receptor, muscarinic 1

multiple interactions
increases expression
affects binding
decreases expression
increases activity
affects response to substance

[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]
Pilocarpine results in increased expression of CHRM1 protein
CHRM1 protein binds to Pilocarpine
Pilocarpine results in decreased expression of CHRM1 protein
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
CHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]
CHRM1 protein affects the susceptibility to Pilocarpine

PMID:9224827 PMID:11527950 PMID:12713643 PMID:14559291 PMID:15967574 More...

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

decreases expression
increases expression
multiple interactions
affects binding

Pilocarpine results in decreased expression of CHRM2 protein
Pilocarpine results in increased expression of CHRM2 protein
eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]
CHRM2 protein binds to Pilocarpine
Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]

PMID:9224827 PMID:14559291 PMID:32234387

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions
increases expression
affects binding

brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
Pilocarpine results in increased expression of CHRM3 protein
CHRM3 protein binds to Pilocarpine

PMID:9224827 PMID:32234387

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions
increases expression
affects binding

Pilocarpine binds to and results in increased activity of CHRM4 protein
Pilocarpine results in increased expression of CHRM4 protein
CHRM4 protein binds to Pilocarpine
brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; eburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]

PMID:9224827 PMID:9920179 PMID:32234387

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

increases expression

Pilocarpine results in increased expression of CHRM5 protein

NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252

G

calcium and integrin binding 1

increases expression

Pilocarpine results in increased expression of CIB1 mRNA

NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423

G

chloride voltage-gated channel 2

affects expression

Pilocarpine affects the expression of CLCN2 protein

NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657

G

calponin 3

increases expression

Pilocarpine results in increased expression of CNN3 protein

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

cannabinoid receptor 1

decreases expression

Pilocarpine results in decreased expression of CNR1 protein

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

ciliary neurotrophic factor

increases expression

Pilocarpine results in increased expression of CNTF mRNA

NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877

G

colony stimulating factor 2

decreases expression
increases expression

Pilocarpine results in decreased expression of CSF2 mRNA
Pilocarpine results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 2 receptor subunit beta

increases expression

Pilocarpine results in increased expression of CSF2RB mRNA

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

G

casein beta

decreases expression
increases expression

Pilocarpine results in decreased expression of CSN2 mRNA
Pilocarpine results in increased expression of CSN2 mRNA

NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817

G

cardiotrophin 1

increases expression

Pilocarpine results in increased expression of CTF1 mRNA

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

catenin beta 1

increases expression

Pilocarpine results in increased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

increases expression

Pilocarpine results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

Pilocarpine results in increased expression of CYP11A1 protein

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

death associated protein 3

increases expression

Pilocarpine results in increased expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

DNA cross-link repair 1A

increases expression

Pilocarpine results in increased expression of DCLRE1A mRNA

NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678

G

DNA-damage inducible transcript 3

increases expression

Pilocarpine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dystrophin

decreases expression

Pilocarpine results in decreased expression of DMD protein

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

dihydropyrimidinase-like 2

increases expression

Pilocarpine results in increased expression of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dopamine receptor D1

increases expression
decreases expression
multiple interactions
increases response to substance

Pilocarpine results in increased expression of DRD1 mRNA
Pilocarpine results in decreased expression of DRD1 protein
Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]
DRD1 protein results in increased susceptibility to Pilocarpine
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine; [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine

PMID:1365435 PMID:7906944 PMID:14656328 PMID:15876489 PMID:16137708

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
decreases expression
decreases response to substance
decreases activity

[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]
Pilocarpine results in decreased expression of DRD2 protein
DRD2 protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased activity of DRD2 protein

PMID:1365435 PMID:11860278 PMID:14559291 PMID:15140183 PMID:15876489 More...

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

ephrin A3

decreases expression

Pilocarpine results in decreased expression of EFNA3 mRNA

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

G

epidermal growth factor receptor

decreases expression

Pilocarpine results in decreased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
multiple interactions

Pilocarpine results in increased expression of EGR1 mRNA
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

multiple interactions
increases expression

Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

multiple interactions
increases expression

Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
Pilocarpine results in increased expression of EGR3 mRNA; Pilocarpine results in increased expression of EGR3 protein

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

EI24, autophagy associated transmembrane protein

decreases expression

Pilocarpine results in decreased expression of EI24 mRNA

NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571

G

eukaryotic translation initiation factor 2-alpha kinase 2

multiple interactions

Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases activity

Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]
Pilocarpine results in increased activity of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]
Pilocarpine results in increased phosphorylation of EIF2S1 protein

PMID:15003282 PMID:16492139

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

EPH receptor A5

decreases expression

Pilocarpine results in decreased expression of EPHA5 mRNA; Pilocarpine results in decreased expression of EPHA5 protein

NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317

G

erythropoietin

increases expression

Pilocarpine results in increased expression of EPO mRNA

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erythropoietin receptor

increases expression

Pilocarpine results in increased expression of EPOR mRNA

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

ERCC excision repair 1, endonuclease non-catalytic subunit

increases expression

Pilocarpine results in increased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 3, TFIIH core complex helicase subunit

increases expression

Pilocarpine results in increased expression of ERCC3 mRNA

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

ezrin

increases expression

Pilocarpine results in increased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II, thrombin

increases activity

Pilocarpine results in increased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibroblast growth factor 2

multiple interactions

FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 5

increases expression

Pilocarpine results in increased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression
increases expression

[Pilocarpine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS protein; [Pilocarpine co-treated with Lithium] results in increased expression of FOS protein; [Pilocarpine co-treated with SCH 23390] results in increased expression of FOS protein; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of FOS mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Pilocarpine results in decreased expression of FOS mRNA
Pilocarpine results in increased expression of FOS mRNA; Pilocarpine results in increased expression of FOS protein

PMID:7713058 PMID:7968354 PMID:7984056 PMID:8281324 PMID:8511714 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Pilocarpine results in increased expression of FOSB protein

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

follicle stimulating hormone subunit beta

decreases expression

Pilocarpine results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions
decreases expression

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression
multiple interactions

Pilocarpine results in increased expression of GABRA4 protein
Pilocarpine results in increased expression of GABRA4 mRNA
Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]

PMID:15456836 PMID:16091474

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha 5

multiple interactions
decreases expression

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]

NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917

G

gamma-aminobutyric acid type A receptor subunit delta

multiple interactions
decreases expression

bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]
Pilocarpine results in decreased expression of GABRD protein

PMID:15456836 PMID:20821261

NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411

G

gamma-aminobutyric acid type A receptor subunit gamma 2

increases expression

Pilocarpine results in increased expression of GABRG2 protein

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glutamate decarboxylase 1

increases expression

Pilocarpine results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

affects expression
increases expression
decreases expression

Pilocarpine affects the expression of GAD2 protein
Pilocarpine results in increased expression of GAD2 mRNA; Pilocarpine results in increased expression of GAD2 protein
Pilocarpine results in decreased expression of GAD2 protein

PMID:12183020 PMID:15857427 PMID:15987249 PMID:16797850

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

growth associated protein 43

decreases expression
increases expression

Pilocarpine results in decreased expression of GAP43 protein
Pilocarpine results in increased expression of GAP43 mRNA

PMID:15191797 PMID:16134595

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

glial cell derived neurotrophic factor

increases expression
multiple interactions

Pilocarpine results in increased expression of GDNF mRNA
[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein

PMID:7854063 PMID:12914250

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

multiple interactions
increases expression
decreases expression

1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP protein; iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Pilocarpine results in increased expression of GFAP protein]]
Pilocarpine results in decreased expression of GFAP protein

PMID:25101675 PMID:30542433 PMID:31018114

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gap junction protein, alpha 1

increases expression
affects localization

Pilocarpine results in increased expression of GJA1 protein
Pilocarpine affects the localization of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamate dehydrogenase 1

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA]

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

glutamate-ammonia ligase

decreases expression

Pilocarpine results in decreased expression of GLUL protein

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutamic--pyruvic transaminase

increases secretion

Pilocarpine results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamate ionotropic receptor AMPA type subunit 1

decreases expression
increases expression

Pilocarpine results in decreased expression of GRIA1 mRNA
Pilocarpine results in increased expression of GRIA1 protein

PMID:7529610 PMID:15857427

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor AMPA type subunit 2

multiple interactions
decreases expression
increases expression

[Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA
Pilocarpine results in decreased expression of GRIA2 mRNA
Pilocarpine results in increased expression of GRIA2 3' UTR alternative form; Pilocarpine results in increased expression of GRIA2 protein

PMID:15857427 PMID:16819974 PMID:19222700

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions
increases expression
decreases expression

[Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA
Pilocarpine results in increased expression of GRIA3 mRNA; Pilocarpine results in increased expression of GRIA3 protein
Pilocarpine results in decreased expression of GRIA3 mRNA

PMID:7529610 PMID:15857427 PMID:16819974

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor kainate type subunit 1

multiple interactions

[Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine

NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645

G

glutamate ionotropic receptor kainate type subunit 2

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA

NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375

G

glutamate ionotropic receptor kainate type subunit 5

multiple interactions

[Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions
decreases expression

Plant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA]

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
increases expression
decreases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]
Pilocarpine results in decreased expression of GRIN2A protein

PMID:15857427 PMID:16600505 PMID:22824136

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression
increases expression
multiple interactions

Pilocarpine results in decreased expression of GRIN2B protein
Pilocarpine results in increased expression of GRIN2B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]

PMID:15857427 PMID:16600505 PMID:22824136

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate metabotropic receptor 1

decreases expression
multiple interactions
increases expression

Pilocarpine results in decreased expression of GRM1 protein
[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of GRM1 mRNA
Pilocarpine results in increased expression of GRM1 protein

PMID:11463519 PMID:32494933

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 2

decreases expression

Pilocarpine results in decreased expression of GRM2 mRNA; Pilocarpine results in decreased expression of GRM2 protein

PMID:16793029 PMID:18585369 PMID:18804094

NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146

G

glutamate metabotropic receptor 3

decreases expression

Pilocarpine results in decreased expression of GRM3 mRNA; Pilocarpine results in decreased expression of GRM3 protein

PMID:16793029 PMID:18585369 PMID:18804094

NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804

G

glutamate metabotropic receptor 5

multiple interactions
decreases expression

[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased expression of GRM5 mRNA; Pilocarpine results in decreased expression of GRM5 protein

PMID:15009663 PMID:17634364

NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274

G

glutamate metabotropic receptor 8

increases expression
decreases expression

Pilocarpine results in increased expression of GRM8 protein
Pilocarpine results in decreased expression of GRM8

PMID:11226630 PMID:12539201

NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

multiple interactions
decreases expression

[Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA
Pilocarpine results in decreased expression of HCN1 protein

PMID:12890777 PMID:21905079

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

hypoxia inducible factor 1 subunit alpha

increases expression

Pilocarpine results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

increases expression

Pilocarpine results in increased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression

Pilocarpine results in increased expression of HMOX1 protein
Pilocarpine results in increased expression of HMOX1 mRNA

PMID:20971094 PMID:25715797 PMID:32234387

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeo box B1

decreases expression

Pilocarpine results in decreased expression of HOXB1 mRNA

NCBI chr10:81,331,507...81,332,928
Ensembl chr10:81,331,507...81,332,836

G

harakiri, BCL2 interacting protein

decreases expression

Pilocarpine results in decreased expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

heat shock factor binding protein 1

decreases expression

Pilocarpine results in decreased expression of HSBP1 mRNA

NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein; Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Pilocarpine results in increased expression of HSPB1 mRNA; Pilocarpine results in increased expression of HSPB1 protein

PMID:17971868 PMID:20971094

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

5-hydroxytryptamine receptor 1A

multiple interactions

[8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine; [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine

PMID:2533336 PMID:15140183

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 1B

multiple interactions

[cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine

NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549

G

5-hydroxytryptamine receptor 2C

multiple interactions
increases expression
decreases expression

Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]
Pilocarpine results in increased expression of HTR2C mRNA; Pilocarpine results in increased expression of HTR2C protein
Pilocarpine results in decreased expression of HTR2C mRNA; Pilocarpine results in decreased expression of HTR2C protein

PMID:19439326 PMID:19700373

NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287

G

interferon gamma

multiple interactions
decreases expression

1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein 3

increases expression

Pilocarpine results in increased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

multiple interactions
decreases expression
increases expression

1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IL10 protein]
Pilocarpine results in increased expression of IL10 protein

PMID:15781040 PMID:17872965

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

increases expression

Pilocarpine results in increased expression of IL12B mRNA

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
Pilocarpine results in increased expression of IL1B mRNA; Pilocarpine results in increased expression of IL1B protein
Pilocarpine results in decreased expression of IL1B mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]

PMID:19010416 PMID:19055492 PMID:19951488 PMID:21087489 PMID:23211629 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression

Pilocarpine results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4 receptor

increases expression

Pilocarpine results in increased expression of IL4R mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

decreases expression
multiple interactions

Pilocarpine results in decreased expression of IL6 mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 protein

PMID:19055492 PMID:31018114

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin-linked kinase

decreases activity

Pilocarpine results in decreased activity of ILK protein

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

inositol monophosphatase 1

increases response to substance
decreases response to substance
affects response to substance

IMPA1 gene mutant form results in increased susceptibility to Pilocarpine
IMPA1 protein results in decreased susceptibility to Pilocarpine
IMPA1 protein affects the susceptibility to Pilocarpine

PMID:17460611 PMID:17602744 PMID:19754464

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313

G

integrin subunit alpha 1

increases expression

Pilocarpine results in increased expression of ITGA1 protein

NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238

G

integrin subunit alpha 2

increases expression

Pilocarpine results in increased expression of ITGA2 protein

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 4

increases expression

Pilocarpine results in increased expression of ITGA4 protein

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha 5

increases expression

Pilocarpine results in increased expression of ITGA5 protein

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit beta 1

decreases expression
increases expression

Pilocarpine results in decreased expression of ITGB1 protein
Pilocarpine results in increased expression of ITGB1 protein

PMID:12851778 PMID:19631748

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 3

increases expression

Pilocarpine results in increased expression of ITGB3 protein

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

integrin subunit beta 4

increases expression

Pilocarpine results in increased expression of ITGB4 protein

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Lithium co-treated with Pilocarpine] results in increased expression of JUN protein; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUN mRNA]

PMID:7984056 PMID:17971868 PMID:19430551

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

PMID:7968354 PMID:7984056

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium voltage-gated channel subfamily C member 4

decreases expression

Pilocarpine results in decreased expression of KCNC4 mRNA; Pilocarpine results in decreased expression of KCNC4 protein

NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233

G

potassium two pore domain channel subfamily K member 5

increases expression
decreases expression

Pilocarpine results in increased expression of KCNK5 protein
Pilocarpine results in decreased expression of KCNK5 protein

NCBI chr15:4,122,442...4,164,718
Ensembl chr15:4,122,442...4,164,718

G

potassium calcium-activated channel subfamily M alpha 1

decreases expression

Pilocarpine results in decreased expression of KCNMA1 mRNA

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

potassium calcium-activated channel subfamily N member 1

decreases expression

Pilocarpine results in decreased expression of KCNN1 protein

NCBI chr16:18,574,858...18,598,585
Ensembl chr16:18,585,992...18,597,482

G

potassium calcium-activated channel subfamily N member 2

decreases expression

Pilocarpine results in decreased expression of KCNN2 mRNA; Pilocarpine results in decreased expression of KCNN2 protein

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

potassium calcium-activated channel subfamily N member 3

decreases expression

Pilocarpine results in decreased expression of KCNN3 mRNA; Pilocarpine results in decreased expression of KCNN3 protein

NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145

G

lysosomal-associated membrane protein 2

multiple interactions
increases expression

Vitamin E inhibits the reaction [Pilocarpine results in increased expression of LAMP2 protein]
Pilocarpine results in increased expression of LAMP2 mRNA; Pilocarpine results in increased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

luteinizing hormone subunit beta

decreases expression

Pilocarpine results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LIF, interleukin 6 family cytokine

increases expression

Pilocarpine results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Pilocarpine results in increased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]

PMID:12091480 PMID:17360923 PMID:18988310 PMID:19402951 PMID:22824136

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Pilocarpine results in increased phosphorylation of MAPK3 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]

PMID:12091480 PMID:17360923 PMID:18988310 PMID:19402951 PMID:22824136

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases activity

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; W 7 inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

myocyte enhancer factor 2C

increases expression

Pilocarpine results in increased expression of MEF2C mRNA

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

O-6-methylguanine-DNA methyltransferase

increases expression

Pilocarpine results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 200c

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] results in increased expression of MIR200C mRNA

NCBI chr 4:157,523,679...157,523,747

G

matrix metallopeptidase 9

increases activity
increases expression

Pilocarpine results in increased activity of MMP9 protein
Pilocarpine results in increased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MRE11 homolog, double strand break repair nuclease

increases expression

Pilocarpine results in increased expression of MRE11A mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

moesin

increases expression

Pilocarpine results in increased expression of MSN mRNA

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

mechanistic target of rapamycin kinase

multiple interactions
increases phosphorylation

dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYD88, innate immune signal transduction adaptor

increases expression

Pilocarpine results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NLR family, apoptosis inhibitory protein 6

decreases expression

Pilocarpine results in decreased expression of NAIP2 mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

nuclear factor of activated T-cells 5

decreases expression

Pilocarpine results in decreased expression of NFAT5 mRNA

NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675

G

NFE2 like bZIP transcription factor 2

increases expression

Pilocarpine results in increased expression of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases expression
multiple interactions
increases phosphorylation

Pilocarpine results in increased expression of NFKBIA mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]

PMID:15193289 PMID:23211629

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions
increases expression

Ketamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]

PMID:8635431 PMID:8821376 PMID:15183516 PMID:17971868

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

increases expression
multiple interactions
increases response to substance

Pilocarpine results in increased expression of NGFR protein
Pilocarpine results in increased expression of NGFR mRNA; Pilocarpine results in increased expression of NGFR protein
PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]
NGFR protein results in increased susceptibility to Pilocarpine

PMID:10436046 PMID:12097334 PMID:18815271 PMID:21084616

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nitric oxide synthase 1

multiple interactions
increases expression

[Pilocarpine co-treated with Lithium] results in increased expression of NOS1 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein]

PMID:18672383 PMID:20149694

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions
increases expression

[Pilocarpine co-treated with Lithium] results in increased expression of NOS2 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]
Pilocarpine results in increased expression of NOS2 mRNA; Pilocarpine results in increased expression of NOS2 protein

PMID:18672383 PMID:20149694 PMID:23211629

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NOVA alternative splicing regulator 1

increases expression
multiple interactions

Pilocarpine results in increased expression of NOVA1 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]

NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289

G

NOVA alternative splicing regulator 2

decreases expression
multiple interactions

Pilocarpine results in decreased expression of NOVA2 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]

NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021

G

neuronal pentraxin 2

increases expression

Pilocarpine results in increased expression of NPTX2 mRNA

NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345

G

neuropeptide Y

decreases response to substance
increases expression

NPY protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in increased expression of NPY protein

PMID:12231234 PMID:12821374 PMID:15451008

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

NAD(P)H quinone dehydrogenase 1

increases expression

Pilocarpine results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neurotrophin 3

decreases expression
multiple interactions

Pilocarpine results in decreased expression of NTF3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 2

multiple interactions
increases expression

Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]

PMID:8635431 PMID:8821376 PMID:15183516 PMID:19686240

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

neurotrophic receptor tyrosine kinase 3

increases expression
multiple interactions

Pilocarpine results in increased expression of NTRK3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

ornithine decarboxylase 1

increases expression

Pilocarpine results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

8-oxoguanine DNA glycosylase

decreases expression

Pilocarpine results in decreased expression of OGG1 mRNA; Pilocarpine results in decreased expression of OGG1 protein

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

opioid receptor, kappa 1

decreases response to substance

OPRK1 protein results in decreased susceptibility to Pilocarpine

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

decreases expression

Pilocarpine results in decreased expression of OPRM1 protein

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

oncostatin M

increases expression

Pilocarpine results in increased expression of OSM mRNA

NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313

G

purinergic receptor P2X 7

increases expression

Pilocarpine results in increased expression of P2RX7 protein

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

poly (ADP-ribose) polymerase 1

affects expression
multiple interactions

Pilocarpine affects the expression of PARP1 protein
3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; [Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]

PMID:25101675 PMID:31396050

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

increases expression

Pilocarpine results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proprotein convertase subtilisin/kexin type 1

increases expression

Pilocarpine results in increased expression of PCSK1 mRNA

NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434

G

pyridoxal kinase like 1

increases expression

Pilocarpine results in increased expression of PDXK protein

NCBI chr20:10,162,934...10,192,572
Ensembl chr20:10,164,099...10,192,739

G

proliferation and apoptosis adaptor protein 15

multiple interactions

[Pilocarpine co-treated with Lithium Chloride co-treated with 3-chloroacetylindole] results in decreased phosphorylation of PEA15 protein; [Pilocarpine co-treated with Lithium Chloride] results in decreased phosphorylation of PEA15 protein

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

phospholipase C, beta 4

increases expression

Pilocarpine results in increased expression of PLCB4 protein

NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392

G

polynucleotide kinase 3'-phosphatase

increases expression

Pilocarpine results in increased expression of PNKP mRNA

NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920

G

pyridoxamine 5'-phosphate oxidase

increases expression

Pilocarpine results in increased expression of PNPO protein

NCBI chr10:81,924,584...81,930,844
Ensembl chr10:81,924,569...81,930,871

G

DNA polymerase gamma, catalytic subunit

increases expression

Pilocarpine results in increased expression of POLG mRNA; Pilocarpine results in increased expression of POLG protein

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Pilocarpine results in increased expression of PPP1R15A protein

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

Pilocarpine results in decreased expression of PPP3R1 mRNA

NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907

G

protein kinase C, beta

increases expression
decreases expression

Pilocarpine results in increased expression of PRKCB protein
Pilocarpine results in decreased expression of PRKCB mRNA

PMID:15058486 PMID:17971868 PMID:18774262

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

increases expression

Pilocarpine results in increased expression of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, gamma

increases expression

Pilocarpine results in increased expression of PRKCG protein

PMID:15058486 PMID:18774262

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

protein kinase C, eta

increases expression

Pilocarpine results in increased expression of PRKCH protein

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

protein kinase C, zeta

increases expression

Pilocarpine results in increased expression of PRKCZ protein

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

phosphatase and tensin homolog

multiple interactions

PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E synthase

increases expression

Pilocarpine results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Pilocarpine results in increased expression of PTGS2 mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]
Pilocarpine results in increased expression of PTGS2 mRNA; Pilocarpine results in increased expression of PTGS2 protein

PMID:15193289 PMID:23211629

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions
increases phosphorylation

[Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein
Pilocarpine results in increased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine kinase 2 beta

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

G

protein tyrosine phosphatase, non-receptor type 5

multiple interactions
decreases response to substance

PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PTPN5 protein mutant form results in decreased susceptibility to Pilocarpine

PMID:17360923 PMID:21204826

NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882

G

protein tyrosine phosphatase, receptor type Z1

affects expression

Pilocarpine affects the expression of PTPRZ1 protein

NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218

G

parvalbumin

decreases expression

Pilocarpine results in decreased expression of PVALB protein

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

quinoid dihydropteridine reductase

increases expression

Pilocarpine results in increased expression of QDPR protein

NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854

G

RAD23 homolog A, nucleotide excision repair protein

increases expression
decreases expression

Pilocarpine results in increased expression of RAD23A mRNA
Pilocarpine results in decreased expression of RAD23A mRNA

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

RAD23 homolog B, nucleotide excision repair protein

increases expression

Pilocarpine results in increased expression of RAD23B mRNA

NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319

G

reversion-inducing-cysteine-rich protein with kazal motifs

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK mRNA; [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK protein

NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; [Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ret proto-oncogene

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased expression of RET protein

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

ribosomal protein L32

multiple interactions

Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]

NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612

G

ribosomal protein S6

multiple interactions
increases phosphorylation

dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

S100 calcium binding protein B

increases expression

Pilocarpine results in increased expression of S100B protein

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

sodium voltage-gated channel beta subunit 2

decreases response to substance

SCN2B protein results in decreased susceptibility to Pilocarpine

NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765

G

sodium voltage-gated channel alpha subunit 8

increases expression

Pilocarpine results in increased expression of SCN8A mRNA; Pilocarpine results in increased expression of SCN8A protein

NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292

G

sirtuin 1

multiple interactions
increases expression

dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Niacinamide inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 12 member 2

increases expression

Pilocarpine results in increased expression of SLC12A2 mRNA; Pilocarpine results in increased expression of SLC12A2 protein

PMID:18550034 PMID:19674083

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 12 member 5

decreases expression
multiple interactions
increases degradation

Pilocarpine results in decreased expression of SLC12A5 mRNA; Pilocarpine results in decreased expression of SLC12A5 protein
Pilocarpine results in increased phosphorylation of and affects the localization of SLC12A5 protein
Pilocarpine results in increased degradation of SLC12A5 protein

PMID:18094240 PMID:18550034 PMID:19674083 PMID:20600929

NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765

G

solute carrier family 17 member 7

increases expression

Pilocarpine results in increased expression of SLC17A7 protein

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 1 member 1

increases expression

Pilocarpine results in increased expression of SLC1A1 mRNA; Pilocarpine results in increased expression of SLC1A1 protein

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 22 member 2

multiple interactions

Pilocarpine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 32 member 1

increases expression

Pilocarpine results in increased expression of SLC32A1 mRNA; Pilocarpine results in increased expression of SLC32A1 protein

NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844

G

solute carrier family 5 member 3

increases response to substance
increases expression
affects response to substance

SLC5A3 gene mutant form results in increased susceptibility to Pilocarpine
Pilocarpine results in increased expression of SLC5A3 mRNA
SLC5A3 protein affects the susceptibility to Pilocarpine

PMID:17602744 PMID:19754464 PMID:21219332

NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883

G

solute carrier family 6 member 1

decreases expression

Pilocarpine results in decreased expression of SLC6A1 protein
Pilocarpine results in decreased expression of SLC6A1 mRNA

PMID:12183020 PMID:21219332

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

solute carrier family 6 member 11

decreases expression

Pilocarpine results in decreased expression of SLC6A11 mRNA

NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443

G

solute carrier family 6 member 12

decreases expression
increases expression

Pilocarpine results in decreased expression of SLC6A12 mRNA
Pilocarpine results in increased expression of SLC6A12 mRNA

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 6 member 6

increases expression

Pilocarpine results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier organic anion transporter family, member 1a4

decreases expression

Pilocarpine results in decreased expression of SLCO1A4 protein

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

slit guidance ligand 2

increases expression
decreases expression

Pilocarpine results in increased expression of SLIT2 protein
Pilocarpine results in decreased expression of SLIT2 protein

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

G

structural maintenance of chromosomes 3

increases expression

Pilocarpine results in increased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

syntrophin, alpha 1

decreases expression

Pilocarpine results in decreased expression of SNTA1 protein

NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709

G

superoxide dismutase 2

increases expression

Pilocarpine results in increased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SPARC like 1

affects localization
decreases expression

Pilocarpine affects the localization of SPARCL1 protein
Pilocarpine results in decreased expression of SPARCL1 protein

PMID:18488994 PMID:18808451

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

[Lithium co-treated with Pilocarpine] results in increased activity of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

somatostatin receptor 1

increases expression

Pilocarpine results in increased expression of SSTR1 protein

NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802

G

somatostatin receptor 2

increases expression

Pilocarpine results in increased expression of SSTR2 protein

NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351

G

somatostatin receptor 3

decreases expression

Pilocarpine results in decreased expression of SSTR3 protein

NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769

G

somatostatin receptor 4

decreases expression
increases expression

Pilocarpine results in decreased expression of SSTR4 protein
Pilocarpine results in increased expression of SSTR4 protein

NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689

G

somatostatin receptor 5

decreases expression
increases expression

Pilocarpine results in decreased expression of SSTR5 protein
Pilocarpine results in increased expression of SSTR5 protein

NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946

G

steroidogenic acute regulatory protein

increases localization

Pilocarpine results in increased localization of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

StAR-related lipid transfer domain containing 6

increases localization
increases expression

Pilocarpine results in increased localization of STARD6 protein
Pilocarpine results in increased expression of STARD6 protein

PMID:19434006 PMID:20609383

NCBI chr18:64,089,618...64,118,528
Ensembl chr18:64,089,471...64,107,099

G

synaptophysin

increases expression

Pilocarpine results in increased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

tachykinin, precursor 1

multiple interactions

[Pilocarpine co-treated with Lithium] results in increased expression of TAC1 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 protein modified form; Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

thymine-DNA glycosylase

increases expression

Pilocarpine results in increased expression of TDG mRNA

NCBI chr 7:21,077,853...21,097,617
Ensembl chr 7:21,077,853...21,097,567

G

transcription factor A, mitochondrial

increases expression

Pilocarpine results in increased expression of TFAM mRNA; Pilocarpine results in increased expression of TFAM protein

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

thyroid hormone receptor beta

increases expression

Pilocarpine results in increased expression of THRB mRNA

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

TIMP metallopeptidase inhibitor 2

increases expression

Pilocarpine results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tight junction protein 1

decreases expression

Pilocarpine results in decreased expression of TJP1 protein

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 2

increases expression

Pilocarpine results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of TLR4 mRNA]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tenascin C

increases expression

Pilocarpine results in increased expression of TNC mRNA

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

increases expression
decreases expression
multiple interactions

Pilocarpine results in increased expression of TNF mRNA
Pilocarpine results in increased expression of TNF protein
Pilocarpine results in decreased expression of TNF mRNA; Pilocarpine results in decreased expression of TNF protein
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF protein; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of TNF protein]

PMID:15193289 PMID:17872965 PMID:18455351 PMID:19055492 PMID:31018114

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

Pilocarpine results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

decreases expression

Pilocarpine results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 13

decreases expression

Pilocarpine results in decreased expression of TNFSF13 mRNA

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

tenascin R

increases expression

Pilocarpine results in increased expression of TNR protein

NCBI chr13:71,751,714...72,172,731
Ensembl chr13:72,091,585...72,167,641

G

three prime repair exonuclease 1

increases expression

Pilocarpine results in increased expression of TREX1 mRNA

NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796

G

thyrotropin releasing hormone

increases expression

Pilocarpine results in increased expression of TRH mRNA

PMID:10443546 PMID:15781040

NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637

G

thyrotropin releasing hormone receptor

decreases activity
decreases expression

Pilocarpine results in decreased activity of TRHR protein
Pilocarpine results in decreased expression of TRHR protein

NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309

G

ubiquitin-conjugating enzyme E2D 3

increases expression

Pilocarpine results in increased expression of UBE2D3 mRNA

NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081

G

ubiquitin-conjugating enzyme E2I

increases expression

Pilocarpine results in increased expression of UBE2I mRNA

NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

vitamin D receptor

increases expression

Pilocarpine results in increased expression of VDR mRNA

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

increases expression

Pilocarpine results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

VGF nerve growth factor inducible

increases expression

Pilocarpine results in increased expression of VGF mRNA

NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341

G

X-ray repair cross complementing 1

increases expression

Pilocarpine results in increased expression of XRCC1 mRNA

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 3

increases expression

Pilocarpine results in increased expression of XRCC3 mRNA

NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444

G

zinc finger protein 110

multiple interactions

ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]

NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086

(S)-timolol (anhydrous)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

Timolol binds to and results in decreased activity of ADRB1 protein; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]

PMID:11436944 PMID:15060759

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions

[Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Timolol binds to and results in decreased activity of ADRB2 protein

PMID:11436944 PMID:17925438

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

amine oxidase, copper containing 1

multiple interactions

Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects response to substance

CYP2D6 gene SNP affects the susceptibility to Timolol

PMID:19284319 PMID:20925579

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

mitogen activated protein kinase 1

multiple interactions

[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]

PMID:11914123 PMID:18977218

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]

PMID:11914123 PMID:18977218

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

regulator of G-protein signaling 3

multiple interactions

RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

regulator of G-protein signaling 4

multiple interactions

RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

brinzolamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho GTPase activating protein 45

affects expression

brinzolamide affects the expression of ARHGAP45 mRNA

NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268

G

carbonic anhydrase 2

multiple interactions

brinzolamide binds to and results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

multiple interactions

brinzolamide binds to and results in decreased activity of CA3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

RT1 class I, locus CE16

affects expression

brinzolamide affects the expression of HLA-A mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

carteolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

Carteolol binds to and results in decreased activity of ADRB1 protein

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions

Carteolol binds to and results in decreased activity of ADRB2 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

arrestin, beta 1

increases expression

Carteolol results in increased expression of ARRB1 protein

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

arrestin, beta 2

increases expression

Carteolol results in increased expression of ARRB2 protein

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

ATM serine/threonine kinase

multiple interactions
increases expression

Carteolol results in increased expression of and results in increased phosphorylation of ATM protein
Carteolol results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

catalase

affects activity

Carteolol affects the activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 27

increases expression

Carteolol results in increased expression of CCL27 mRNA

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

cyclin-dependent kinase inhibitor 1A

affects expression

Carteolol affects the expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases expression

Carteolol results in increased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

fumarylacetoacetate hydrolase domain containing 1

affects expression

Carteolol affects the expression of FAHD1 mRNA

NCBI chr10:13,873,539...13,874,978
Ensembl chr10:13,873,527...13,875,012

G

glutathione peroxidase 1

affects activity

Carteolol affects the activity of GPX1 protein

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

H2A.X variant histone

increases phosphorylation

Carteolol results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hexokinase 2

affects expression

Carteolol affects the expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

interleukin 10

increases expression

Carteolol results in increased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

increases expression

Carteolol results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 6

increases expression

Carteolol results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lamin B1

decreases expression

Carteolol results in decreased expression of LMNB1 protein

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

microtubule-associated protein 1 light chain 3 beta

affects localization

Carteolol affects the localization of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions

Carteolol results in increased expression of and results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Carteolol results in increased expression of and results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

marker of proliferation Ki-67

decreases expression

Carteolol results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mechanistic target of rapamycin kinase

affects expression

Carteolol affects the expression of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

nicotinamide phosphoribosyltransferase

affects expression

Carteolol affects the expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

NFE2 like bZIP transcription factor 2

affects expression

Carteolol affects the expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

increases expression

Carteolol results in increased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NADPH oxidase 4

increases expression

Carteolol results in increased expression of NOX4 protein

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

poly (ADP-ribose) polymerase 1

affects expression

Carteolol affects the expression of PARP1 mRNA

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

sirtuin 1

affects expression

Carteolol affects the expression of SIRT1 mRNA

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

superoxide dismutase 1

affects activity

Carteolol affects the activity of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

affects activity

Carteolol affects the activity of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transforming growth factor, beta 1

increases expression

Carteolol results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression

Carteolol results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

affects expression

Carteolol affects the expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

D-mannitol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA carboxylase beta

decreases expression

Mannitol results in decreased expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

ATP citrate lyase

increases expression

Mannitol results in increased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

ADAM metallopeptidase with thrombospondin type 1 motif, 18

increases expression

Mannitol results in increased expression of ADAMTS18 mRNA

NCBI chr19:41,686,951...41,840,035
Ensembl chr19:41,688,617...41,839,781

G

axin interactor, dorsalization associated

decreases expression

Mannitol results in decreased expression of AIDA mRNA

NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920

G

autoimmune regulator

decreases expression

Mannitol results in decreased expression of AIRE mRNA

NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060

G

aquaporin 9

increases uptake

AQP9 protein results in increased uptake of Mannitol

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

Rho GTPase activating protein 1

increases expression

Mannitol results in increased expression of ARHGAP1 mRNA

NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396

G

arrestin 3

increases expression

Mannitol results in increased expression of ARR3 mRNA

NCBI chr X:65,699,881...65,712,224
Ensembl chr X:65,698,699...65,712,153

G

BCL2-associated agonist of cell death

increases phosphorylation
multiple interactions

Mannitol results in increased phosphorylation of BAD protein
wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

gamma-butyrobetaine hydroxylase 1

decreases expression

Mannitol results in decreased expression of BBOX1 mRNA

NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458

G

BCL2, apoptosis regulator

increases expression

Mannitol results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Cdk5 and Abl enzyme substrate 2

decreases expression

Mannitol results in decreased expression of CABLES2 mRNA

NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279

G

caspase 3

multiple interactions
increases activity

IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]

PMID:10567913 PMID:12011046 PMID:29803612

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Mannitol results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

chromobox 1

increases expression

Mannitol results in increased expression of CBX1 mRNA

NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096

G

coiled-coil domain containing 127

decreases expression

Mannitol results in decreased expression of CCDC127 mRNA

NCBI chr 1:28,928,420...28,935,885
Ensembl chr 1:28,928,325...28,935,893

G

cellular communication network factor 3

decreases expression

Mannitol results in decreased expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cytoskeleton associated protein 5

increases expression

Mannitol results in increased expression of CKAP5 mRNA

NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264

G

chloride voltage-gated channel 3

affects response to substance

CLCN3 protein affects the susceptibility to Mannitol deficiency

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

catenin alpha 2

decreases expression

Mannitol results in decreased expression of CTNNA2 mRNA

NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522

G

dopamine beta-hydroxylase

increases expression

Mannitol results in increased expression of DBH mRNA

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

dynactin subunit 2

increases expression

Mannitol results in increased expression of DCTN2 mRNA

NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543

G

defensin beta 4

decreases expression

Mannitol results in decreased expression of DEFB7 mRNA

NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665

G

diacylglycerol kinase, alpha

increases expression

Mannitol results in increased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

E74 like ETS transcription factor 2

increases expression

Mannitol results in increased expression of ELF2 mRNA

NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947

G

family with sequence similarity 185, member A

increases expression

Mannitol results in increased expression of FAM185A mRNA

NCBI chr 4:13,542,022...13,662,967
Ensembl chr 4:13,608,464...13,662,967

G

family with sequence similarity 222, member A

decreases expression

Mannitol results in decreased expression of FAM222A mRNA

NCBI chr12:41,982,064...42,033,085
Ensembl chr12:41,986,780...42,033,682

G

fibroblast growth factor 23

decreases export
decreases expression
multiple interactions

Mannitol results in decreased export of FGF23 protein
Mannitol results in decreased expression of FGF23 mRNA
Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 mRNA]; Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 protein]

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Mannitol results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

galactose-3-O-sulfotransferase 2

decreases expression

Mannitol results in decreased expression of GAL3ST2 mRNA

NCBI chr 9:94,382,456...94,387,990

G

growth arrest-specific 2 like 2

decreases expression

Mannitol results in decreased expression of GAS2L2 mRNA

NCBI chr10:68,222,475...68,229,877
Ensembl chr10:68,222,475...68,229,881

G

glypican 6

increases expression

Mannitol results in increased expression of GPC6 mRNA

NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006

G

G protein-coupled receptor 19

decreases expression

Mannitol results in decreased expression of GPR19 mRNA

NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036

G

heme oxygenase 1

increases expression

Mannitol results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

increases expression

Mannitol results in increased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

histamine receptor H 2

increases expression

Mannitol results in increased expression of HRH2 mRNA

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

intercellular adhesion molecule 1

multiple interactions

Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor 1

multiple interactions

IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 6

multiple interactions

Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Rotenone inhibits the reaction [Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Mannitol results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KH domain containing 3, subcortical maternal complex member

increases expression

Mannitol results in increased expression of KHDC3 mRNA

NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248

G

keratin associated protein 11-1

increases expression

Mannitol results in increased expression of KRTAP11-1 mRNA

NCBI chr11:28,809,940...28,810,944
Ensembl chr11:28,810,341...28,810,892

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Mannitol results in decreased expression of LSM6 mRNA

NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484

G

mitogen activated protein kinase kinase 1

multiple interactions

Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions

Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 8

multiple interactions

Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

metastasis associated 1 family, member 2

increases expression

Mannitol results in increased expression of MTA2 mRNA

NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946

G

myosin light chain 9

decreases phosphorylation

Mannitol results in decreased phosphorylation of MYL9 protein

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase 3

increases expression

Mannitol results in increased expression of MYLK3 mRNA

NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954

G

N-acetylated alpha-linked acidic dipeptidase 2

increases expression

Mannitol results in increased expression of NAALAD2 mRNA

NCBI chr 8:15,406,119...15,479,714
Ensembl chr 8:15,407,043...15,479,714

G

NADH:ubiquinone oxidoreductase subunit A13

decreases expression

Mannitol results in decreased expression of NDUFA13 mRNA

NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726

G

nuclear factor of activated T-cells 5

increases expression
multiple interactions

Mannitol results in increased expression of NFAT5 mRNA
Mannitol results in increased expression of NFAT5 mRNA; Mannitol results in increased expression of NFAT5 protein
Mannitol inhibits the reaction [Sodium Chloride deficiency results in decreased expression of NFAT5 mRNA]

PMID:23867654 PMID:37992803

NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675

G

natural killer cell granule protein 7

increases expression

Mannitol results in increased expression of NKG7 mRNA

NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983

G

natriuretic peptide A

increases expression

Mannitol results in increased expression of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

neurotensin

increases transport

NTS protein results in increased transport of Mannitol

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

ornithine aminotransferase

multiple interactions

Mannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

Purkinje cell protein 2

increases expression

Mannitol results in increased expression of PCP2 mRNA

NCBI chr12:1,681,659...1,683,899
Ensembl chr12:1,681,659...1,683,899

G

programmed cell death 4

increases expression
decreases expression

Mannitol results in increased expression of PDCD4 mRNA
Mannitol results in decreased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

phosphate regulating endopeptidase X-linked

increases expression

Mannitol results in increased expression of PHEX mRNA

NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469

G

phospholipase C-like 2

decreases expression

Mannitol results in decreased expression of PLCL2 mRNA

NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009

G

pleckstrin homology domain containing O1

increases expression

Mannitol results in increased expression of PLEKHO1 mRNA

NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785

G

POU class 1 homeobox 1

increases expression

Mannitol results in increased expression of POU1F1 mRNA

NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801

G

protein phosphatase 1, regulatory subunit 10

decreases expression

Mannitol results in decreased expression of PPP1R10 mRNA

NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611

G

protein phosphatase 4, catalytic subunit

increases expression

Mannitol results in increased expression of PPP4C mRNA

NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659

G

protein kinase C, beta

multiple interactions

Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein]

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

multiple interactions

Mannitol inhibits the reaction [Glucose results in increased expression of PRKCD protein]

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prostaglandin E receptor 1

increases expression

Mannitol results in increased expression of PTGER1 mRNA

NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559

G

prostaglandin E receptor 4

decreases expression

Mannitol results in decreased expression of PTGER4 mRNA

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

protein tyrosine kinase 2

multiple interactions

benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein]; Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

ral guanine nucleotide dissociation stimulator like 3

increases expression

Mannitol results in increased expression of RGL3 mRNA

NCBI chr 8:20,500,846...20,520,471
Ensembl chr 8:20,500,846...20,520,471

G

RB transcriptional corepressor like 1

decreases expression

Mannitol results in decreased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

retinol binding protein 2

decreases expression

Mannitol results in decreased expression of RBP2 mRNA

NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473

G

sterile alpha motif domain containing 10

decreases expression

Mannitol results in decreased expression of SAMD10 mRNA

NCBI chr 3:168,700,280...168,704,427
Ensembl chr 3:168,700,284...168,705,248

G

suprabasin

decreases expression

Mannitol results in decreased expression of SBSN mRNA

NCBI chr 1:85,978,970...86,006,034
Ensembl chr 1:86,001,567...86,006,034

G

selectin E

multiple interactions

Mannitol inhibits the reaction [Glucose results in increased expression of SELE mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

small G protein signaling modulator 3

decreases expression

Mannitol results in decreased expression of SGSM3 mRNA

NCBI chr 7:112,514,453...112,544,109
Ensembl chr 7:112,514,630...112,544,108

G

solute carrier family 12 member 1

increases activity
multiple interactions

Mannitol results in increased activity of SLC12A1 protein
[Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water

NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899

G

solute carrier family 2 member 8

decreases expression

Mannitol results in decreased expression of SLC2A8 mRNA

NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

syntaxin 8

decreases expression

Mannitol results in decreased expression of STX8 mRNA

NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993

G

T-cell immunoglobulin and mucin domain containing 4

decreases expression

Mannitol results in decreased expression of TIMD4 mRNA

NCBI chr10:31,185,751...31,221,843
Ensembl chr10:31,185,731...31,220,966

G

tumor necrosis factor

multiple interactions

Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

increases expression

Mannitol results in increased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

tumor protein p53

multiple interactions

Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein D52

decreases expression
increases expression

Mannitol results in decreased expression of TPD52 mRNA
Mannitol results in increased expression of TPD52 mRNA

NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622

G

tripartite motif family-like 1

increases expression

Mannitol results in increased expression of TRIML1 mRNA

NCBI chr16:48,994,968...49,005,343
Ensembl chr16:48,997,252...49,005,417

G

UL16 binding protein 1

increases expression

Mannitol results in increased expression of ULBP1 mRNA

NCBI chr 1:1,694,255...1,716,160

G

vascular cell adhesion molecule 1

multiple interactions

Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

WD repeat domain 20

decreases expression

Mannitol results in decreased expression of WDR20 mRNA

NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339

G

zinc finger protein 13

decreases expression

Mannitol results in decreased expression of ZFP13 mRNA

NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615

G

zymogen granule protein 16

decreases expression

Mannitol results in decreased expression of ZG16 mRNA

NCBI chr 1:181,657,722...181,660,079
Ensembl chr 1:181,657,722...181,660,079

diclofenamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 2

multiple interactions

Dichlorphenamide binds to and results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

multiple interactions

Dichlorphenamide binds to and results in decreased activity of CA3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

dorzolamide hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 2

multiple interactions

dorzolamide binds to and results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

multiple interactions

dorzolamide binds to and results in decreased activity of CA3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

ecothiopate iodide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Echothiophate Iodide results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

albumin

affects binding

Echothiophate Iodide binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

butyrylcholinesterase

decreases activity
multiple interactions

Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]

PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

neutral cholesterol ester hydrolase 1

decreases activity

Echothiophate Iodide results in decreased activity of NCEH1 protein

NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588

epinastine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

affects transport

ABCB1A affects the transport of epinastine

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects transport

ABCB1B affects the transport of epinastine

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

histamine receptor H 1

multiple interactions

[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]

PMID:12832840 PMID:19075512

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

interferon gamma

multiple interactions

epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 13

decreases expression

epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 4

multiple interactions

epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]

PMID:16534218 PMID:19075512

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

decreases expression

epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

decreases expression

epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

potassium voltage-gated channel subfamily H member 2

decreases activity

epinastine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

nerve growth factor

decreases expression

epinastine results in decreased expression of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

solute carrier family 22 member 2

multiple interactions

epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

ethoxzolamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 1

multiple interactions

Ethoxzolamide binds to and results in decreased activity of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

multiple interactions

Ethoxzolamide binds to and results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

multiple interactions

Ethoxzolamide binds to and results in decreased activity of CA3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

fluprostenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fatty acid binding protein 4

multiple interactions

fluprostenol inhibits the reaction [Niacin results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fibroblast growth factor receptor 2

decreases expression

fluprostenol results in decreased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

glutamate cysteine ligase, modifier subunit

multiple interactions

AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

heme oxygenase 1

multiple interactions

AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]
fluprostenol results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]
fluprostenol results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

peroxisome proliferator-activated receptor gamma

multiple interactions

fluprostenol inhibits the reaction [Niacin results in increased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin F receptor

multiple interactions

PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]]

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

thioredoxin reductase 1

multiple interactions

fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]]

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

latanoprost

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

latanoprost results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

levobunolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RT1 class II, locus DMb

affects expression

Levobunolol affects the expression of HLA-DMB mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

metipranolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

multiple interactions

Metipranolol inhibits the reaction [Zinc results in increased expression of BCL2 protein]; Metipranolol inhibits the reaction [Zinc Sulfate results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

Metipranolol inhibits the reaction [Zinc results in increased cleavage of CASP3 protein]; Metipranolol inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

G protein-coupled receptor kinase 1

multiple interactions

Metipranolol inhibits the reaction [Zinc results in decreased expression of GRK1 protein]; Metipranolol inhibits the reaction [Zinc Sulfate results in decreased expression of GRK1 protein]

NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792

G

poly (ADP-ribose) polymerase 1

multiple interactions

Metipranolol inhibits the reaction [Zinc results in decreased expression of PARP1 protein]; Metipranolol inhibits the reaction [Zinc Sulfate results in decreased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

natamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

clusterin

increases expression

Natamycin results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

ceruloplasmin

increases expression

Natamycin results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

fibrinogen alpha chain

increases expression

Natamycin results in increased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen gamma chain

increases expression

Natamycin results in increased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

hepatitis A virus cellular receptor 1

increases expression

Natamycin results in increased expression of HAVCR1 mRNA

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

keratin 19

increases expression

Natamycin results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

lipocalin 2

increases expression

Natamycin results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

secreted phosphoprotein 1

increases expression

Natamycin results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

TIMP metallopeptidase inhibitor 1

increases expression

Natamycin results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

pindolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

increases expression
affects binding
increases activity
multiple interactions

Pindolol results in increased expression of ADRB1 protein
Pindolol binds to ADRB1 protein
Pindolol results in increased activity of ADRB1 protein
[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; CGP 20712A affects the reaction [Pindolol results in increased activity of ADRB1 protein]; Pindolol binds to and results in decreased activity of ADRB1 protein; Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Pindolol binds to and results in decreased activity of ADRB1 protein; Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]

PMID:2175014 PMID:2462161 PMID:2888869 PMID:12761341 PMID:14730417 More...

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

decreases expression
affects binding
multiple interactions

Pindolol results in decreased expression of ADRB2 protein
Pindolol binds to ADRB2 protein
Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Pindolol binds to and results in decreased activity of ADRB2 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]

PMID:2175014 PMID:2462161 PMID:14730417 PMID:17925438

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

Pindolol binds to and results in increased activity of ADRB3 protein
[Pindolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Pindolol binds to and results in increased activity of ADRB3 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]

PMID:1682311 PMID:7815362 PMID:14730417

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

angiotensinogen

multiple interactions

Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

5-hydroxytryptamine receptor 1A

multiple interactions

Pindolol binds to and affects the activity of HTR1A protein; Pindolol binds to and results in decreased activity of HTR1A protein

PMID:2207497 PMID:9809859

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 1B

affects binding

Pindolol binds to HTR1B protein

NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549

G

mitogen activated protein kinase 1

multiple interactions

[Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

prolactin

multiple interactions

Pindolol inhibits the reaction [Buspirone results in increased secretion of PRL protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

renin

multiple interactions
decreases expression
decreases activity

Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]
Pindolol results in decreased expression of REN protein
Pindolol results in decreased activity of REN protein

PMID:791319 PMID:973972 PMID:7104148

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19831
role	19807
application	19650
pharmaceutical	19491
drug	19491
ophthalmology drug	437
antiglaucoma drug +	423
apraclonidine +	0
dapiprazole	0
diclofenamide	2
dipivefrin	0
epinastine +	11
lotilaner	0
natamycin	9
perfluorohexyloctane	0
polyhexamethylene biguanide hydrochloride	0
prednisolone sodium phosphate	0
tetrahydrozoline nitrate	0
travoprost	0

paths to the root