Ntrk3 (neurotrophic receptor tyrosine kinase 3) - Rat Genome Database

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Gene: Ntrk3 (neurotrophic receptor tyrosine kinase 3) Rattus norvegicus
Analyze
Symbol: Ntrk3
Name: neurotrophic receptor tyrosine kinase 3
RGD ID: 3214
Description: Enables GPI-linked ephrin receptor activity. Involved in several processes, including negative regulation of astrocyte differentiation; nervous system development; and response to corticosterone. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of borna disease. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3); PARTICIPATES IN neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GP145-TrkC; neural receptor protein-tyrosine kinase; neural receptor protein-tyrosine kinase (trkC); neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; trk-C; trkC; trkC tyrosine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp138
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81141,526,192 - 141,913,575 (-)NCBIGRCr8
mRatBN7.21132,116,472 - 132,503,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,038,778 - 140,410,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,208,513 - 147,579,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,126,320 - 140,497,270 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01139,890,537 - 140,262,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,868,261 - 141,239,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,925,530 - 134,302,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,003,872 - 134,380,482 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium silicate  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP,ISO)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentobarbital  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
terbufos  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension involved in regeneration  (ISO)
cell differentiation  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,ISO)
cellular response to nerve growth factor stimulus  (IBA)
cellular response to retinoic acid  (IEP)
circadian rhythm  (ISO)
cochlea development  (IEP)
ephrin receptor signaling pathway  (IEA)
heart development  (IEA,ISO,ISS)
lens fiber cell differentiation  (ISO)
mechanoreceptor differentiation  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of astrocyte differentiation  (IMP)
negative regulation of protein phosphorylation  (IEA,ISO)
nervous system development  (IEA)
neuron fate specification  (IMP)
neuron migration  (IMP)
neuronal action potential propagation  (ISO)
neurotrophin signaling pathway  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of axon extension involved in regeneration  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neuron projection development  (IBA,IDA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of synapse assembly  (ISO)
postsynaptic density assembly  (EXP,IDA)
regulation of neural precursor cell proliferation  (IMP)
regulation of presynapse assembly  (IDA,IMP)
response to axon injury  (IEP)
response to corticosterone  (IEP)
response to ethanol  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker. Behrouz Sharif S, etal., Oncol Lett. 2016 Dec;12(6):5335-5343. doi: 10.3892/ol.2016.5327. Epub 2016 Oct 31.
2. Long non-coding RNA LINC00978 promotes cell proliferation and tumorigenesis via regulating microRNA-497/NTRK3 axis in gastric cancer. Bu JY, etal., Int J Biol Macromol. 2019 Feb 15;123:1106-1114. doi: 10.1016/j.ijbiomac.2018.11.162. Epub 2018 Nov 17.
3. TrkC overexpression enhances survival and migration of neural stem cell transplants in the rat spinal cord. Castellanos DA, etal., Cell Transplant. 2002;11(3):297-307.
4. Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer. Chen Z, etal., J Transl Med. 2021 Feb 16;19(1):73. doi: 10.1186/s12967-021-02740-6.
5. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
6. Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats. Fernyhough P, etal., Diabetologia. 1998 Mar;41(3):300-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function. Gestwa G, etal., J Comp Neurol. 1999 Nov 8;414(1):33-49.
9. Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland. Ghinelli E, etal., Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3352-7.
10. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Hajebrahimi Z, etal., Neurosci Lett. 2008 Aug 29;441(3):261-6. Epub 2008 Jun 21.
11. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. He Z, etal., J Neurosci. 2012 Jul 4;32(27):9383-95. doi: 10.1523/JNEUROSCI.6363-11.2012.
12. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
13. TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Ivanov SV, etal., Oncogene. 2013 Aug 8;32(32):3698-710. doi: 10.1038/onc.2012.377. Epub 2012 Oct 1.
14. TrkC plays an essential role in breast tumor growth and metastasis. Jin W, etal., Carcinogenesis. 2010 Nov;31(11):1939-47. doi: 10.1093/carcin/bgq180. Epub 2010 Aug 28.
15. Neurotrophin-3 administration alters neurotrophin, neurotrophin receptor and nestin mRNA expression in rat dorsal root ganglia following axotomy. Kuo LT, etal., Neuroscience. 2007 Jun 29;147(2):491-507. Epub 2007 May 29.
16. Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum. Light KE, etal., Brain Res. 2002 Jan 4;924(1):71-81.
17. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. Marler KJ, etal., J Neurosci. 2008 Nov 26;28(48):12700-12. doi: 10.1523/JNEUROSCI.1915-08.2008.
18. Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Merlio JP, etal., Neuroscience 1992 Dec;51(3):513-32.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Miknyoczki SJ, etal., Int J Cancer. 1999 May 5;81(3):417-27.
21. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
22. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
23. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Moqrich A, etal., Nat Neurosci. 2004 Aug;7(8):812-8. Epub 2004 Jul 11.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition. Nilsson E, etal., Reproduction. 2009 Oct;138(4):697-707. doi: 10.1530/REP-09-0179. Epub 2009 Jul 7.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. Gangliosides activate Trk receptors by inducing the release of neurotrophins. Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
31. Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat. Roskoden T, etal., Exp Brain Res. 2004 Jan;154(2):183-91. Epub 2003 Oct 14.
32. Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma. Sakamoto Y, etal., Oncol Rep. 2001 May-Jun;8(3):477-84.
33. Effects of coffee bean aroma on the rat brain stressed by sleep deprivation: a selected transcript- and 2D gel-based proteome analysis. Seo HS, etal., J Agric Food Chem. 2008 Jun 25;56(12):4665-73. Epub 2008 Jun 3.
34. Differential tyrosine kinase C mRNA distribution in extensor digitorum longus and soleus motoneurons in adult rats: effect of axotomy and neurotrophin-3 treatment. Simon M, etal., Neurosci Lett 2002 Mar 1;320(1-2):9-12.
35. Postsynaptic TrkC and presynaptic PTPs function as a bidirectional excitatory synaptic organizing complex. Takahashi H, etal., Neuron. 2011 Jan 27;69(2):287-303. doi: 10.1016/j.neuron.2010.12.024.
36. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. Takahashi J, etal., J Neurobiol. 1999 Jan;38(1):65-81.
37. Alternative forms of rat TrkC with different functional capabilities. Valenzuela DM, etal., Neuron 1993 May;10(5):963-74.
38. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Wood LD, etal., Hum Mutat. 2006 Oct;27(10):1060-1.
39. Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. Zocher M, etal., J Neurovirol. 2000 Dec;6(6):462-77.
Additional References at PubMed
PMID:8494648   PMID:9856458   PMID:10207144   PMID:10486198   PMID:10908605   PMID:11248116   PMID:12471037   PMID:12477932   PMID:12605901   PMID:12858046   PMID:12882335   PMID:12944916  
PMID:14499950   PMID:15304335   PMID:15376326   PMID:16142215   PMID:17072373   PMID:17316612   PMID:17584746   PMID:17686986   PMID:17967490   PMID:18957307   PMID:19141250   PMID:19549834  
PMID:20553714   PMID:21221027   PMID:21441969   PMID:21456016   PMID:21783247   PMID:23136392   PMID:23382219   PMID:23785138   PMID:23954828   PMID:24198040   PMID:24316227   PMID:24484474  
PMID:24613359   PMID:24753016   PMID:25196463   PMID:25398493   PMID:25624497   PMID:27830679   PMID:28614398   PMID:34970951  


Genomics

Comparative Map Data
Ntrk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81141,526,192 - 141,913,575 (-)NCBIGRCr8
mRatBN7.21132,116,472 - 132,503,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,038,778 - 140,410,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,208,513 - 147,579,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,126,320 - 140,497,270 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01139,890,537 - 140,262,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,868,261 - 141,239,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,925,530 - 134,302,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,003,872 - 134,380,482 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBICelera
Cytogenetic Map1q31NCBI
NTRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381587,859,751 - 88,256,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1587,859,751 - 88,256,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371588,402,982 - 88,799,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,220,992 - 86,600,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 341586,220,991 - 86,600,665NCBI
Celera1564,821,267 - 65,200,916 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1564,532,241 - 64,911,404 (-)NCBIHuRef
CHM1_11588,261,800 - 88,641,816 (-)NCBICHM1_1
T2T-CHM13v2.01585,614,323 - 86,011,407 (-)NCBIT2T-CHM13v2.0
Ntrk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39777,825,711 - 78,228,865 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl777,825,707 - 78,387,760 (-)EnsemblGRCm39 Ensembl
GRCm38778,179,986 - 78,581,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,175,959 - 78,738,012 (-)EnsemblGRCm38mm10GRCm38
MGSCv37785,337,000 - 85,722,724 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36778,066,072 - 78,451,488 (-)NCBIMGSCv36mm8
Celera775,610,791 - 75,991,488 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.01NCBI
Ntrk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,652,791 - 17,018,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,652,931 - 17,018,188 (+)NCBIChiLan1.0ChiLan1.0
NTRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21677,421,258 - 77,808,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,101,703 - 81,513,473 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01566,566,219 - 66,953,279 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11585,776,819 - 86,157,209 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1585,776,832 - 86,157,204 (-)Ensemblpanpan1.1panPan2
NTRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,131,470 - 51,491,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,138,751 - 51,513,024 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,770,192 - 54,150,627 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0351,548,386 - 51,933,727 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl351,554,220 - 51,933,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,071,744 - 51,456,495 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,281,270 - 51,665,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0351,620,674 - 52,005,592 (-)NCBIUU_Cfam_GSD_1.0
Ntrk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640132,042,602 - 132,426,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648313,909,109 - 14,291,887 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648313,912,904 - 14,291,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,535,301 - 191,925,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,938,371 - 213,258,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1296,441,824 - 6,831,029 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl296,447,256 - 6,830,526 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605940,018,915 - 40,410,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476815,252,354 - 15,619,601 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476815,239,111 - 15,619,979 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ntrk3
2219 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:613
Count of miRNA genes:207
Interacting mature miRNAs:231
Transcripts:ENSRNOT00000025536, ENSRNOT00000041839, ENSRNOT00000045165, ENSRNOT00000046080, ENSRNOT00000046849, ENSRNOT00000047776
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat

Markers in Region
D1Uia12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,214,399 - 132,214,546 (+)MAPPERmRatBN7.2
Rnor_6.01139,972,085 - 139,972,231NCBIRnor6.0
Rnor_5.01140,949,643 - 140,949,789UniSTSRnor5.0
RGSC_v3.41134,007,903 - 134,008,050RGDRGSC3.4
RGSC_v3.41134,007,904 - 134,008,050UniSTSRGSC3.4
RGSC_v3.11134,086,246 - 134,086,393RGD
Celera1124,287,809 - 124,287,955UniSTS
Cytogenetic Map1q31UniSTS
D1Mco67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,256,726 - 132,256,925 (+)MAPPERmRatBN7.2
Rnor_6.01140,014,403 - 140,014,601NCBIRnor6.0
Rnor_5.01140,992,120 - 140,992,318UniSTSRnor5.0
RGSC_v3.41134,051,455 - 134,051,653UniSTSRGSC3.4
Celera1124,330,125 - 124,330,323UniSTS
Cytogenetic Map1q31UniSTS
BE106688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,132,876 - 132,133,043 (+)MAPPERmRatBN7.2
Rnor_6.01139,890,565 - 139,890,731NCBIRnor6.0
Rnor_5.01140,868,289 - 140,868,455UniSTSRnor5.0
RGSC_v3.41133,925,533 - 133,925,699UniSTSRGSC3.4
Celera1124,206,137 - 124,206,303UniSTS
RH 3.4 Map11053.3UniSTS
Cytogenetic Map1q31UniSTS
Ntrk3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,383,823 - 132,383,927 (+)MAPPERmRatBN7.2
Rnor_6.01140,141,474 - 140,141,577NCBIRnor6.0
Rnor_5.01141,118,729 - 141,118,832UniSTSRnor5.0
RGSC_v3.41134,180,066 - 134,180,169UniSTSRGSC3.4
Celera1124,456,732 - 124,456,835UniSTS
Cytogenetic Map1q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 1 64 10 1
Low 1 36 17 5 17 5 8 8 10 33 31 10 8
Below cutoff 2 7 23 23 1 23 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L03813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S60953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000025536   ⟹   ENSRNOP00000025536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,234,519 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,992,204 - 140,262,452 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000041839   ⟹   ENSRNOP00000046059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000045165   ⟹   ENSRNOP00000049463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,890,715 - 140,262,452 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000046849   ⟹   ENSRNOP00000044402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,890,715 - 140,262,452 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110436   ⟹   ENSRNOP00000094926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,234,193 - 132,503,286 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114826   ⟹   ENSRNOP00000096233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,260,318 - 132,503,286 (-)Ensembl
RefSeq Acc Id: NM_001270655   ⟹   NP_001257584
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,542,569 - 141,913,004 (-)NCBI
mRatBN7.21132,132,849 - 132,503,286 (-)NCBI
Rnor_6.01139,890,537 - 140,262,503 (-)NCBI
Rnor_5.01140,868,261 - 141,239,954 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270656   ⟹   NP_001257585
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,542,569 - 141,913,004 (-)NCBI
mRatBN7.21132,132,849 - 132,503,286 (-)NCBI
Rnor_6.01139,890,537 - 140,262,503 (-)NCBI
Rnor_5.01140,868,261 - 141,239,954 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019248   ⟹   NP_062121
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,542,569 - 141,913,004 (-)NCBI
mRatBN7.21132,132,849 - 132,503,286 (-)NCBI
Rnor_6.01139,890,537 - 140,262,503 (-)NCBI
Rnor_5.01140,868,261 - 141,239,954 (-)NCBI
RGSC_v3.41133,925,530 - 134,302,139 (-)RGD
Celera1124,206,109 - 124,576,015 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759513   ⟹   XP_008757735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,642,292 - 141,913,575 (-)NCBI
mRatBN7.21132,232,568 - 132,503,829 (-)NCBI
Rnor_6.01139,990,256 - 140,262,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109631   ⟹   XP_038965559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,600,598 - 141,913,549 (-)NCBI
mRatBN7.21132,190,886 - 132,503,829 (-)NCBI
RefSeq Acc Id: XM_039109638   ⟹   XP_038965566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,600,132 - 141,913,549 (-)NCBI
mRatBN7.21132,189,358 - 132,503,829 (-)NCBI
RefSeq Acc Id: XM_063287704   ⟹   XP_063143774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,526,192 - 141,913,568 (-)NCBI
RefSeq Acc Id: XM_063287717   ⟹   XP_063143787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,642,292 - 141,913,568 (-)NCBI
RefSeq Acc Id: NP_062121   ⟸   NM_019248
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A8L2ULV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257584   ⟸   NM_001270655
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A8L2ULV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257585   ⟸   NM_001270656
- Peptide Label: isoform 1 precursor
- UniProtKB: Q03351 (UniProtKB/Swiss-Prot),   A0A8L2ULV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757735   ⟸   XM_008759513
- Peptide Label: isoform X3
- UniProtKB: Q68G04 (UniProtKB/TrEMBL),   A0A8I6ALQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000049463   ⟸   ENSRNOT00000045165
RefSeq Acc Id: ENSRNOP00000046059   ⟸   ENSRNOT00000041839
RefSeq Acc Id: ENSRNOP00000044402   ⟸   ENSRNOT00000046849
RefSeq Acc Id: ENSRNOP00000025536   ⟸   ENSRNOT00000025536
RefSeq Acc Id: XP_038965566   ⟸   XM_039109638
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ALQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965559   ⟸   XM_039109631
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094926   ⟸   ENSRNOT00000110436
RefSeq Acc Id: ENSRNOP00000096233   ⟸   ENSRNOT00000114826
RefSeq Acc Id: XP_063143774   ⟸   XM_063287704
- Peptide Label: isoform X1
- UniProtKB: A0A8L2ULV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143787   ⟸   XM_063287717
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ALQ4 (UniProtKB/TrEMBL),   Q68G04 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03351-F1-model_v2 AlphaFold Q03351 1-864 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3214 AgrOrtholog
BioCyc Gene G2FUF-58842 BioCyc
Ensembl Genes ENSRNOG00000018674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055008845 UniProtKB/Swiss-Prot
  ENSRNOG00060003667 UniProtKB/Swiss-Prot
  ENSRNOG00065029604 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025536.6 UniProtKB/Swiss-Prot
  ENSRNOT00000041839 ENTREZGENE
  ENSRNOT00000041839.4 UniProtKB/Swiss-Prot
  ENSRNOT00000045165 ENTREZGENE
  ENSRNOT00000045165.4 UniProtKB/Swiss-Prot
  ENSRNOT00000046849 ENTREZGENE
  ENSRNOT00000046849.6 UniProtKB/TrEMBL
  ENSRNOT00000110436.1 UniProtKB/TrEMBL
  ENSRNOT00000114826.1 UniProtKB/Swiss-Prot
  ENSRNOT00055014935 UniProtKB/Swiss-Prot
  ENSRNOT00060006109 UniProtKB/Swiss-Prot
  ENSRNOT00065051242 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121171 IMAGE-MGC_LOAD
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTRK_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kin_neurotrophic_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29613 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93481 IMAGE-MGC_LOAD
NCBI Gene 29613 ENTREZGENE
PANTHER BASIGIN RELATED UniProtKB/TrEMBL
  DOWN SYNDROME CELL ADHESION MOLECULE 3, ISOFORM E-RELATED UniProtKB/TrEMBL
  NT-3 GROWTH FACTOR RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TPKR_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ntrk3 PhenoGen
PRINTS NTKRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTKRECEPTOR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018674 RatGTEx
  ENSRNOG00055008845 RatGTEx
  ENSRNOG00060003667 RatGTEx
  ENSRNOG00065029604 RatGTEx
SMART LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ALQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2ULV7 ENTREZGENE, UniProtKB/TrEMBL
  NTRK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G04 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ntrk3  neurotrophic receptor tyrosine kinase 3  Ntrk3  neurotrophic tyrosine kinase, receptor, type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ntrk3  neurotrophic tyrosine kinase, receptor, type 3    neural receptor protein-tyrosine kinase  Name updated 1299863 APPROVED
2002-06-10 Ntrk3  neural receptor protein-tyrosine kinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by GM1 gangliosides 727459
gene_transcript multiple alternative splice forms exist and may have different functional capabilities 729049