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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butan-4-olide
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Accession:CHEBI:22950 term browser browse the term
Definition:Any gamma-lactone having the lactone moiety derived from 4-hydroxybutanoic acid.
Synonyms:related_synonym: butan-4-olides;   butanolide


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(+)-pilocarpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Pilocarpine results in increased expression of A2M mRNA CTD PMID:17971868 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression
increases expression
EXP Pilocarpine affects the expression of ABCB1A mRNA
Pilocarpine results in increased expression of ABCB1A mRNA; Pilocarpine results in increased expression of ABCB1A protein
CTD PMID:14706787, PMID:17437408, PMID:19055492 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects expression
increases expression
EXP Pilocarpine affects the expression of ABCB1B mRNA
Pilocarpine results in increased expression of ABCB1B mRNA; Pilocarpine results in increased expression of ABCB1B protein
CTD PMID:14706787, PMID:19055492, PMID:19570321 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects expression EXP Pilocarpine affects the expression of ABCC1 mRNA CTD PMID:19055492 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Pilocarpine results in increased expression of ABCC2 protein CTD PMID:16504477 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 affects expression EXP Pilocarpine affects the expression of ABCC5 mRNA CTD PMID:19055492 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE protein] CTD PMID:32494933 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
increases expression
decreases expression
EXP
ISO
Pilocarpine results in decreased activity of ACHE protein
garcinielliptone FC inhibits the reaction [Pilocarpine results in decreased activity of ACHE protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]; [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
Pilocarpine results in increased expression of ACHE mRNA alternative form; Pilocarpine results in increased expression of ACHE protein alternative form
CTD PMID:16481111, PMID:18242586, PMID:18333967, PMID:19669875, PMID:19932735, PMID:19941057, PMID:20730314, PMID:24911645 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actb actin, beta multiple interactions ISO Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein] CTD PMID:16492139 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP [2-chloro-N(6)cyclopentyladenosine binds to and results in increased activity of ADORA1 protein] which results in decreased susceptibility to Pilocarpine CTD PMID:11311893 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pilocarpine CTD PMID:19488739 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Pilocarpine CTD PMID:19125850 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Agrn agrin increases expression EXP Pilocarpine results in increased expression of AGRN protein CTD PMID:17971868 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of AGTR1A protein] CTD PMID:32494933 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of AGTR2 mRNA CTD PMID:32494933 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP Pilocarpine results in increased expression of AIF1 protein CTD PMID:18226170 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akap5 A-kinase anchoring protein 5 increases response to substance ISO AKAP5 protein mutant form results in increased susceptibility to Pilocarpine CTD PMID:18711127 NCBI chr 6:99,356,509...99,361,909
Ensembl chr 6:99,356,509...99,361,909
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Pilocarpine results in decreased phosphorylation of AKT1 protein
[Lithium Chloride co-treated with Pilocarpine] results in increased phosphorylation of AKT1 protein
CTD PMID:19429016, PMID:31018114 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase decreases expression
decreases activity
multiple interactions
EXP
ISO
Pilocarpine results in decreased expression of ALAD protein
Pilocarpine results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]
Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]; Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]
CTD PMID:19798568, PMID:20026167, PMID:20584200, PMID:25490531 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ank3 ankyrin 3 increases expression EXP Pilocarpine results in increased expression of ANK3 mRNA; Pilocarpine results in increased expression of ANK3 protein CTD PMID:19306853 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression
affects localization
decreases expression
EXP Pilocarpine results in increased expression of APEX1 mRNA
Pilocarpine affects the localization of APEX1 mRNA
Pilocarpine results in decreased expression of APEX1 protein
CTD PMID:17971868, PMID:20206232, PMID:20446108 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression EXP Pilocarpine results in decreased expression of APLP1 mRNA CTD PMID:19448684 NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750
JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Pilocarpine results in decreased expression of AQP4 protein CTD PMID:20886625 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Aqp5 aquaporin 5 multiple interactions
affects localization
ISO Atropine inhibits the reaction [Pilocarpine affects the localization of AQP5 protein] CTD PMID:26208470 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Pilocarpine results in decreased expression of ASIC1 mRNA CTD PMID:11162239 NCBI chr 7:141,324,714...141,354,937
Ensembl chr 7:141,326,321...141,354,937
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Pilocarpine results in decreased expression of ASIC2 mRNA alternative form CTD PMID:11162239 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions
increases expression
EXP [Lithium co-treated with Pilocarpine] results in decreased expression of ATF2 protein
Pilocarpine results in increased expression of ATF2 mRNA
CTD PMID:17971868, PMID:19430551 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Pilocarpine results in increased expression of ATP2A2 protein CTD PMID:15288437 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression EXP Pilocarpine results in increased expression of ATRX mRNA CTD PMID:17971868 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BAX mRNA
Pilocarpine results in increased expression of BAX mRNA; Pilocarpine results in increased expression of BAX protein
CTD PMID:14754538, PMID:17971868, PMID:19429016 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Chlorpyrifos co-treated with Pilocarpine] results in decreased activity of BCHE protein CTD PMID:22874420 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl10 BCL10, immune signaling adaptor decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BCL10 mRNA
Pilocarpine results in increased expression of BCL10 mRNA
CTD PMID:17971868 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Pilocarpine results in decreased expression of BCL2 protein CTD PMID:19429016 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression EXP Pilocarpine results in increased expression of BCL2A1 mRNA CTD PMID:17971868 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases response to substance ISO BDKRB1 protein mutant form results in decreased susceptibility to Pilocarpine CTD PMID:15196965 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 protein mutant form results in increased susceptibility to Pilocarpine CTD PMID:15196965 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of BDNF protein modified form
Pilocarpine results in increased expression of BDNF exon; Pilocarpine results in increased expression of BDNF mRNA; Pilocarpine results in increased expression of BDNF mRNA alternative form; Pilocarpine results in increased expression of BDNF protein
Pilocarpine results in decreased expression of BDNF protein
1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 1 alpha,24-dihydroxyvitamin D3 promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA alternative form]; [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA; Pilocarpine results in increased expression of and results in increased localization of BDNF protein; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
CTD PMID:8405262, PMID:8635431, PMID:8821376, PMID:9015327, PMID:9073163, PMID:11259499, PMID:12231234, PMID:14656328, PMID:15183516, PMID:15282290, PMID:15781040, PMID:19397936, PMID:19686240, PMID:21087489 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 mRNA]; Vitamin E inhibits the reaction [Pilocarpine results in increased expression of BECN1 protein]
Pilocarpine results in increased expression of BECN1 mRNA; Pilocarpine results in increased expression of BECN1 protein
CTD PMID:17971868, PMID:19138675 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of BMP4 mRNA
Pilocarpine results in increased expression of BMP4 mRNA
CTD PMID:17971868 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression EXP Pilocarpine results in increased expression of BNIP1 mRNA CTD PMID:17971868 NCBI chr10:16,677,077...16,689,321
Ensembl chr10:16,677,077...16,689,321
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Pilocarpine results in increased expression of BNIP3 mRNA CTD PMID:17971868 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1A protein
Pilocarpine results in increased expression of CACNA1A protein
CTD PMID:17265461 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1B mRNA; Pilocarpine results in decreased expression of CACNA1B protein
Pilocarpine results in increased expression of CACNA1B protein
CTD PMID:19811616 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1C protein
Pilocarpine results in increased expression of CACNA1C protein
CTD PMID:17265461 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CACNA1D protein
Pilocarpine results in increased expression of CACNA1D protein
CTD PMID:17265461 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Casp12 caspase 12 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
[Pilocarpine co-treated with Lithium] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Pilocarpine results in increased cleavage of and results in increased activity of CASP3 protein; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Pilocarpine results in increased expression of CASP3 protein modified form
CTD PMID:12097334, PMID:18708038, PMID:18815271, PMID:19429016, PMID:19631748, PMID:19927300, PMID:20149694, PMID:21062633, PMID:22824136 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions EXP Pilocarpine results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:12097334 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp9 caspase 9 increases expression ISO Pilocarpine results in increased expression of CASP9 protein CTD PMID:18708038 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity
increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased activity of CAT protein
Pilocarpine results in increased expression of CAT protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]; Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]
Levetiracetam inhibits the reaction [Pilocarpine results in increased activity of CAT protein]
CTD PMID:15245787, PMID:15752349, PMID:16115668, PMID:17205390, PMID:17383094, PMID:18242586 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
decreases expression
EXP
ISO
Pilocarpine results in increased expression of CCL2 mRNA; Pilocarpine results in increased expression of CCL2 protein
Pilocarpine results in decreased expression of CCL2 protein
CTD PMID:15193289, PMID:17971868, PMID:19490431, PMID:20034406 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
increases expression
ISO Pilocarpine results in decreased expression of CCL3 protein
Pilocarpine results in increased expression of CCL3 mRNA
CTD PMID:19490431 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 decreases expression ISO Pilocarpine results in decreased expression of CCR10 mRNA; Pilocarpine results in decreased expression of CCR10 protein CTD PMID:17181556 NCBI chr10:89,086,556...89,088,993
Ensembl chr10:89,086,556...89,088,993
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
decreases expression
EXP
ISO
Pilocarpine results in increased expression of CCR2 protein
Pilocarpine results in decreased expression of CCR2 mRNA; Pilocarpine results in decreased expression of CCR2 protein
CTD PMID:19490431, PMID:20034406
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO Pilocarpine results in decreased expression of CCR3 mRNA; Pilocarpine results in decreased expression of CCR3 protein CTD PMID:19490431 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO Pilocarpine results in decreased expression of CCR7 mRNA; Pilocarpine results in decreased expression of CCR7 protein CTD PMID:17181556 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO Pilocarpine results in decreased expression of CCR8 mRNA; Pilocarpine results in decreased expression of CCR8 protein CTD PMID:17181556 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 decreases expression ISO Pilocarpine results in decreased expression of CCR9 mRNA; Pilocarpine results in decreased expression of CCR9 protein CTD PMID:17181556 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
EXP Pilocarpine results in increased expression of CD40 protein
rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of CD40 protein]
CTD PMID:18455351 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Pilocarpine results in increased expression of CD44 protein CTD PMID:15191797 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CDH1 protein
Pilocarpine results in increased expression of CDH1 protein
CTD PMID:12387456 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 increases expression EXP Pilocarpine results in increased expression of CDH2 mRNA; Pilocarpine results in increased expression of CDH2 protein CTD PMID:12125071, PMID:12387456 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Pilocarpine results in increased expression of CDK1 mRNA CTD PMID:14656328 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Pilocarpine results in increased expression of CDK2 mRNA CTD PMID:17971868 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Pilocarpine results in increased expression of CDKN1B mRNA CTD PMID:17971868 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CDKN2A mRNA
Pilocarpine results in increased expression of CDKN2A mRNA
CTD PMID:17971868 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of CEBPA mRNA] CTD PMID:32494933 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chat choline O-acetyltransferase decreases activity
multiple interactions
decreases expression
EXP Pilocarpine results in decreased activity of CHAT protein
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein
Pilocarpine results in decreased expression of CHAT protein
CTD PMID:19669875, PMID:19932735, PMID:19941057 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
increases expression
affects binding
decreases expression
increases activity
affects response to substance
ISO
EXP
[Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; brucine promotes the reaction [Pilocarpine binds to CHRM1 protein]
Pilocarpine results in increased expression of CHRM1 protein
CHRM1 protein binds to Pilocarpine
Pilocarpine results in decreased expression of CHRM1 protein
Pilocarpine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
CHRM1 protein mutant form inhibits the reaction [Pilocarpine results in increased hydrolysis of Phosphatidylinositols]
CHRM1 protein affects the susceptibility to Pilocarpine
CTD PMID:9224827, PMID:11527950, PMID:12713643, PMID:14559291, PMID:15967574, PMID:16137708, PMID:16563474, PMID:32234387 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression
increases expression
multiple interactions
affects binding
EXP
ISO
Pilocarpine results in decreased expression of CHRM2 protein
Pilocarpine results in increased expression of CHRM2 protein
eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein]
CHRM2 protein binds to Pilocarpine
Pilocarpine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]
CTD PMID:9224827, PMID:14559291, PMID:32234387 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
increases expression
affects binding
ISO brucine promotes the reaction [Pilocarpine binds to CHRM3 protein]
Pilocarpine results in increased expression of CHRM3 protein
CHRM3 protein binds to Pilocarpine
CTD PMID:9224827, PMID:32234387 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
increases expression
affects binding
EXP
ISO
Pilocarpine binds to and results in increased activity of CHRM4 protein
Pilocarpine results in increased expression of CHRM4 protein
CHRM4 protein binds to Pilocarpine
brucine promotes the reaction [Pilocarpine binds to CHRM4 protein]; eburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein]
CTD PMID:9224827, PMID:9920179, PMID:32234387 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 increases expression ISO Pilocarpine results in increased expression of CHRM5 protein CTD PMID:32234387 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Cib1 calcium and integrin binding 1 increases expression EXP Pilocarpine results in increased expression of CIB1 mRNA CTD PMID:17971868 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525
JBrowse link
G Clcn2 chloride voltage-gated channel 2 affects expression EXP Pilocarpine affects the expression of CLCN2 protein CTD PMID:16930566 NCBI chr11:82,862,664...82,876,165
Ensembl chr11:83,883,879...83,897,394
JBrowse link
G Cnn3 calponin 3 increases expression EXP Pilocarpine results in increased expression of CNN3 protein CTD PMID:14620880 NCBI chr 2:225,005,069...225,036,179
Ensembl chr 2:225,005,019...225,036,188
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases expression EXP Pilocarpine results in decreased expression of CNR1 protein CTD PMID:19368833 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Pilocarpine results in increased expression of CNTF mRNA CTD PMID:10506506 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CSF2 mRNA
Pilocarpine results in increased expression of CSF2 mRNA
CTD PMID:17971868 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression EXP Pilocarpine results in increased expression of CSF2RB mRNA CTD PMID:17166730 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Csn2 casein beta decreases expression
increases expression
EXP Pilocarpine results in decreased expression of CSN2 mRNA
Pilocarpine results in increased expression of CSN2 mRNA
CTD PMID:17971868 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Ctf1 cardiotrophin 1 increases expression EXP Pilocarpine results in increased expression of CTF1 mRNA CTD PMID:10506506 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Pilocarpine results in increased expression of CTNNB1 protein CTD PMID:12387456 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsd cathepsin D increases expression EXP Pilocarpine results in increased expression of CTSD mRNA CTD PMID:17971868 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Pilocarpine results in increased expression of CYP11A1 protein CTD PMID:19125849 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Dap3 death associated protein 3 increases expression EXP Pilocarpine results in increased expression of DAP3 mRNA CTD PMID:17971868 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dclre1a DNA cross-link repair 1A increases expression EXP Pilocarpine results in increased expression of DCLRE1A mRNA CTD PMID:17971868 NCBI chr 1:277,335,792...277,355,701
Ensembl chr 1:277,335,790...277,355,075
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Pilocarpine results in increased expression of DDIT3 mRNA CTD PMID:17971868 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dmd dystrophin decreases expression EXP Pilocarpine results in decreased expression of DMD protein CTD PMID:20886625 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Pilocarpine results in increased expression of DPYSL2 protein CTD PMID:17366478 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression
multiple interactions
increases response to substance
EXP
ISO
Pilocarpine results in increased expression of DRD1 mRNA
Pilocarpine results in decreased expression of DRD1 protein
Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]
DRD1 protein results in increased susceptibility to Pilocarpine
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine; [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine
CTD PMID:1365435, PMID:7906944, PMID:14656328, PMID:15876489, PMID:16137708 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases expression
decreases response to substance
decreases activity
EXP
ISO
[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]
Pilocarpine results in decreased expression of DRD2 protein
DRD2 protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased activity of DRD2 protein
CTD PMID:1365435, PMID:11860278, PMID:14559291, PMID:15140183, PMID:15876489, PMID:16137708 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Efna3 ephrin A3 decreases expression EXP Pilocarpine results in decreased expression of EFNA3 mRNA CTD PMID:18772502 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP Pilocarpine results in decreased expression of EGFR mRNA CTD PMID:17971868 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of EGR1 mRNA
Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]
CTD PMID:7968354 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 multiple interactions
increases expression
EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 multiple interactions
increases expression
EXP Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
Pilocarpine results in increased expression of EGR3 mRNA; Pilocarpine results in increased expression of EGR3 protein
CTD PMID:16091474 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression EXP Pilocarpine results in decreased expression of EI24 mRNA CTD PMID:17971868 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions ISO Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine results in increased phosphorylation of and results in increased activity of EIF2AK2 protein CTD PMID:16492139 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases activity
ISO Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]
Pilocarpine results in increased activity of EIF2AK3 protein
CTD PMID:16492139 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO Pilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]; Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]
Pilocarpine results in increased phosphorylation of EIF2S1 protein
CTD PMID:15003282, PMID:16492139 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Epha5 EPH receptor A5 decreases expression EXP Pilocarpine results in decreased expression of EPHA5 mRNA; Pilocarpine results in decreased expression of EPHA5 protein CTD PMID:18772502 NCBI chr14:25,589,312...25,958,258
Ensembl chr14:25,589,762...25,958,227
JBrowse link
G Epo erythropoietin increases expression EXP Pilocarpine results in increased expression of EPO mRNA CTD PMID:17166730 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor increases expression EXP Pilocarpine results in increased expression of EPOR mRNA CTD PMID:17166730 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression EXP Pilocarpine results in increased expression of ERCC1 mRNA CTD PMID:17971868 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression EXP Pilocarpine results in increased expression of ERCC3 mRNA CTD PMID:17971868 NCBI chr18:25,037,668...25,068,380
Ensembl chr18:25,037,625...25,068,389
JBrowse link
G Ezr ezrin increases expression EXP Pilocarpine results in increased expression of EZR protein CTD PMID:17366478 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F2 coagulation factor II increases activity ISO Pilocarpine results in increased activity of F2 protein CTD PMID:30515700 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein] CTD PMID:21087489 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression EXP Pilocarpine results in increased expression of FGF5 mRNA CTD PMID:8167846 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
increases expression
EXP [Pilocarpine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS protein; [Pilocarpine co-treated with Lithium] results in increased expression of FOS protein; [Pilocarpine co-treated with SCH 23390] results in increased expression of FOS protein; Atropine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of FOS mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Pilocarpine results in decreased expression of FOS mRNA
Pilocarpine results in increased expression of FOS mRNA; Pilocarpine results in increased expression of FOS protein
CTD PMID:7713058, PMID:7968354, PMID:7984056, PMID:8281324, PMID:8511714, PMID:9630518, PMID:17971868 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Pilocarpine results in increased expression of FOSB protein CTD PMID:16391389 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Pilocarpine results in decreased expression of FSHB protein CTD PMID:9761326 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
decreases expression
EXP bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA] CTD PMID:20821261 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of GABRA4 protein
Pilocarpine results in increased expression of GABRA4 mRNA
Pilocarpine promotes the reaction [EGR3 protein binds to GABRA4 promoter]
CTD PMID:15456836, PMID:16091474 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
decreases expression
EXP bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA5 mRNA] CTD PMID:20821261 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta multiple interactions
decreases expression
EXP
ISO
bacoside A inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRD mRNA]
Pilocarpine results in decreased expression of GABRD protein
CTD PMID:15456836, PMID:20821261 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Pilocarpine results in increased expression of GABRG2 protein CTD PMID:15456836 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Pilocarpine results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 affects expression
increases expression
decreases expression
EXP Pilocarpine affects the expression of GAD2 protein
Pilocarpine results in increased expression of GAD2 mRNA; Pilocarpine results in increased expression of GAD2 protein
Pilocarpine results in decreased expression of GAD2 protein
CTD PMID:12183020, PMID:15857427, PMID:15987249, PMID:16797850 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gap43 growth associated protein 43 decreases expression
increases expression
ISO
EXP
Pilocarpine results in decreased expression of GAP43 protein
Pilocarpine results in increased expression of GAP43 mRNA
CTD PMID:15191797, PMID:16134595 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
multiple interactions
EXP Pilocarpine results in increased expression of GDNF mRNA
[Lithium co-treated with Pilocarpine] results in increased expression of GDNF protein
CTD PMID:7854063, PMID:12914250 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression
EXP [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of GFAP protein
Pilocarpine results in decreased expression of GFAP protein
CTD PMID:25101675, PMID:31018114 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
affects localization
EXP Pilocarpine results in increased expression of GJA1 protein
Pilocarpine affects the localization of GJA1 protein
CTD PMID:21177194 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA] CTD PMID:32494933 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Pilocarpine results in decreased expression of GLUL protein CTD PMID:25101675 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO Pilocarpine results in increased secretion of GPT protein CTD PMID:32234387 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of GRIA1 mRNA
Pilocarpine results in increased expression of GRIA1 protein
CTD PMID:7529610, PMID:15857427 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
decreases expression
increases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIA2 mRNA
Pilocarpine results in decreased expression of GRIA2 mRNA
Pilocarpine results in increased expression of GRIA2 3' UTR alternative form; Pilocarpine results in increased expression of GRIA2 protein
CTD PMID:15857427, PMID:16819974, PMID:19222700 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 multiple interactions
increases expression
decreases expression
EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIA3 mRNA
Pilocarpine results in increased expression of GRIA3 mRNA; Pilocarpine results in increased expression of GRIA3 protein
Pilocarpine results in decreased expression of GRIA3 mRNA
CTD PMID:7529610, PMID:15857427, PMID:16819974 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions EXP [Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine CTD PMID:12080343 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of GRIK2 mRNA CTD PMID:16819974 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions EXP [Lithium co-treated with Pilocarpine] results in decreased expression of GRIK5 mRNA CTD PMID:16819974 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
decreases expression
EXP Plant Preparations inhibits the reaction [Pilocarpine results in decreased expression of GRIN1 mRNA] CTD PMID:18086456 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
increases expression
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2A protein; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein]
Pilocarpine results in decreased expression of GRIN2A protein
CTD PMID:15857427, PMID:16600505, PMID:22824136 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression
increases expression
multiple interactions
EXP Pilocarpine results in decreased expression of GRIN2B protein
Pilocarpine results in increased expression of GRIN2B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; [Lithium co-treated with Pilocarpine] results in increased phosphorylation of GRIN2B protein; Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]
CTD PMID:15857427, PMID:16600505, PMID:22824136 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression
multiple interactions
increases expression
EXP Pilocarpine results in decreased expression of GRM1 protein
[Dexamethasone co-treated with Lithium Chloride co-treated with Pilocarpine] affects the expression of GRM1 mRNA
Pilocarpine results in increased expression of GRM1 protein
CTD PMID:11463519, PMID:32494933 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm2 glutamate metabotropic receptor 2 decreases expression EXP Pilocarpine results in decreased expression of GRM2 mRNA; Pilocarpine results in decreased expression of GRM2 protein CTD PMID:16793029, PMID:18585369, PMID:18804094 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link
G Grm3 glutamate metabotropic receptor 3 decreases expression EXP Pilocarpine results in decreased expression of GRM3 mRNA; Pilocarpine results in decreased expression of GRM3 protein CTD PMID:16793029, PMID:18585369, PMID:18804094 NCBI chr 4:21,316,761...21,567,561
Ensembl chr 4:21,317,695...21,560,490
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
decreases expression
EXP [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine
Pilocarpine results in decreased expression of GRM5 mRNA; Pilocarpine results in decreased expression of GRM5 protein
CTD PMID:15009663, PMID:17634364 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Grm8 glutamate metabotropic receptor 8 increases expression
decreases expression
EXP Pilocarpine results in increased expression of GRM8 protein
Pilocarpine results in decreased expression of GRM8
CTD PMID:11226630, PMID:12539201 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions
decreases expression
EXP [Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA
Pilocarpine results in decreased expression of HCN1 protein
CTD PMID:12890777, PMID:21905079 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression EXP Pilocarpine results in increased expression of HIF1A mRNA CTD PMID:17166730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hk2 hexokinase 2 increases expression EXP Pilocarpine results in increased expression of HK2 mRNA CTD PMID:17971868 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
Pilocarpine results in increased expression of HMOX1 protein
Pilocarpine results in increased expression of HMOX1 mRNA
CTD PMID:20971094, PMID:25715797, PMID:32234387 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxb1 homeo box B1 decreases expression EXP Pilocarpine results in decreased expression of HOXB1 mRNA CTD PMID:17971868 NCBI chr10:84,214,358...84,215,812
Ensembl chr10:84,214,358...84,215,687
JBrowse link
G Hrk harakiri, BCL2 interacting protein decreases expression EXP Pilocarpine results in decreased expression of HRK mRNA CTD PMID:17971868 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsbp1 heat shock factor binding protein 1 decreases expression EXP Pilocarpine results in decreased expression of HSBP1 mRNA CTD PMID:17971868 NCBI chr19:51,985,196...51,989,528
Ensembl chr19:51,985,170...51,989,544
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein; Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein] CTD PMID:21429313 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Pilocarpine results in increased expression of HSPB1 mRNA; Pilocarpine results in increased expression of HSPB1 protein CTD PMID:17971868, PMID:20971094 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine; [[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine CTD PMID:2533336, PMID:15140183 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP [cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine CTD PMID:2533336 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression
decreases expression
EXP Carbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Carbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]; Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]; Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]; Plant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]; Plant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]
Pilocarpine results in increased expression of HTR2C mRNA; Pilocarpine results in increased expression of HTR2C protein
Pilocarpine results in decreased expression of HTR2C mRNA; Pilocarpine results in decreased expression of HTR2C protein
CTD PMID:19439326, PMID:19700373 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP 1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IFNG protein] CTD PMID:15781040 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression EXP Pilocarpine results in increased expression of IGFBP3 mRNA CTD PMID:17971868 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
increases expression
EXP 1 alpha,24-dihydroxyvitamin D3 inhibits the reaction [Pilocarpine results in decreased expression of IL10 protein]
Pilocarpine results in increased expression of IL10 protein
CTD PMID:15781040, PMID:17872965 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases expression ISO Pilocarpine results in increased expression of IL12B mRNA CTD PMID:15193289 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO
EXP
[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]
Pilocarpine results in increased expression of IL1B mRNA; Pilocarpine results in increased expression of IL1B protein
Pilocarpine results in decreased expression of IL1B mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL1B protein; BDNF inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; FGF2 inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]
CTD PMID:19010416, PMID:19055492, PMID:19951488, PMID:21087489, PMID:23211629, PMID:31018114 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression EXP Pilocarpine results in decreased expression of IL2 mRNA CTD PMID:17971868 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4r interleukin 4 receptor increases expression EXP Pilocarpine results in increased expression of IL4R mRNA CTD PMID:17971868 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of IL6 mRNA
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of IL6 protein
CTD PMID:19055492, PMID:31018114 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilk integrin-linked kinase decreases activity ISO Pilocarpine results in decreased activity of ILK protein CTD PMID:19631748 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Impa1 inositol monophosphatase 1 increases response to substance
decreases response to substance
affects response to substance
ISO IMPA1 gene mutant form results in increased susceptibility to Pilocarpine
IMPA1 protein results in decreased susceptibility to Pilocarpine
IMPA1 protein affects the susceptibility to Pilocarpine
CTD PMID:17460611, PMID:17602744, PMID:19754464 NCBI chr 2:93,675,203...93,696,355
Ensembl chr 2:93,675,203...93,696,232
JBrowse link
G Itga1 integrin subunit alpha 1 increases expression EXP Pilocarpine results in increased expression of ITGA1 protein CTD PMID:12851778 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga2 integrin subunit alpha 2 increases expression EXP Pilocarpine results in increased expression of ITGA2 protein CTD PMID:12851778 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression EXP Pilocarpine results in increased expression of ITGA4 protein CTD PMID:12851778 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression EXP Pilocarpine results in increased expression of ITGA5 protein CTD PMID:12851778 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression
increases expression
ISO
EXP
Pilocarpine results in decreased expression of ITGB1 protein
Pilocarpine results in increased expression of ITGB1 protein
CTD PMID:12851778, PMID:19631748 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb3 integrin subunit beta 3 increases expression EXP Pilocarpine results in increased expression of ITGB3 protein CTD PMID:12851778 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb4 integrin subunit beta 4 increases expression EXP Pilocarpine results in increased expression of ITGB4 protein CTD PMID:12851778 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Lithium co-treated with Pilocarpine] results in increased expression of JUN protein; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056, PMID:17971868, PMID:19430551 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Atropine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Lithium promotes the reaction [Pilocarpine results in increased expression of JUNB mRNA]; Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354, PMID:7984056 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 decreases expression EXP Pilocarpine results in decreased expression of KCNC4 mRNA; Pilocarpine results in decreased expression of KCNC4 protein CTD PMID:20971086 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455
JBrowse link
G Kcnk5 potassium two pore domain channel subfamily K member 5 increases expression
decreases expression
EXP Pilocarpine results in increased expression of KCNK5 protein
Pilocarpine results in decreased expression of KCNK5 protein
CTD PMID:19220408 NCBI chr15:4,554,603...4,597,000
Ensembl chr15:4,554,603...4,597,000
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 decreases expression EXP Pilocarpine results in decreased expression of KCNMA1 mRNA CTD PMID:18695509 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Kcnn1 potassium calcium-activated channel subfamily N member 1 decreases expression EXP Pilocarpine results in decreased expression of KCNN1 protein CTD PMID:20553876 NCBI chr16:20,325,270...20,349,163
Ensembl chr16:20,336,638...20,348,804
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases expression EXP Pilocarpine results in decreased expression of KCNN2 mRNA; Pilocarpine results in decreased expression of KCNN2 protein CTD PMID:20553876 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Kcnn3 potassium calcium-activated channel subfamily N member 3 decreases expression EXP Pilocarpine results in decreased expression of KCNN3 mRNA; Pilocarpine results in decreased expression of KCNN3 protein CTD PMID:20553876 NCBI chr 2:188,837,280...188,991,794
Ensembl chr 2:188,844,073...188,988,774
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Pilocarpine results in increased expression of LAMP2 protein]
Pilocarpine results in increased expression of LAMP2 mRNA; Pilocarpine results in increased expression of LAMP2 protein
CTD PMID:19272430 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Pilocarpine results in decreased expression of LHB protein CTD PMID:9761326 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression EXP Pilocarpine results in increased expression of LIF mRNA CTD PMID:10506506 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Pilocarpine results in increased phosphorylation of MAPK1 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12091480, PMID:17360923, PMID:18988310, PMID:19402951, PMID:22824136 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
Pilocarpine results in increased phosphorylation of MAPK3 protein
Celecoxib inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
CTD PMID:12091480, PMID:17360923, PMID:18988310, PMID:19402951, PMID:22824136 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein]; W 7 inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mef2c myocyte enhancer factor 2C increases expression EXP Pilocarpine results in increased expression of MEF2C mRNA CTD PMID:18949272 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Pilocarpine results in increased expression of MGMT mRNA CTD PMID:17971868 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir200c microRNA 200c multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] results in increased expression of MIR200C mRNA CTD PMID:31018114 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
ISO Pilocarpine results in increased activity of MMP9 protein
Pilocarpine results in increased expression of MMP9 protein
CTD PMID:19631748 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease increases expression EXP Pilocarpine results in increased expression of MRE11A mRNA CTD PMID:17971868 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Msn moesin increases expression EXP Pilocarpine results in increased expression of MSN mRNA CTD PMID:14656328 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
EXP dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of MTOR protein] CTD PMID:23211629 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression EXP Pilocarpine results in increased expression of MYD88 mRNA CTD PMID:17971868 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression EXP Pilocarpine results in decreased expression of NAIP2 mRNA CTD PMID:17971868 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 decreases expression ISO Pilocarpine results in decreased expression of NFAT5 mRNA CTD PMID:21219332 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Pilocarpine results in increased expression of NFE2L2 protein CTD PMID:32234387 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Pilocarpine results in increased expression of NFKBIA mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]
CTD PMID:15193289, PMID:23211629 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Ketamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA] CTD PMID:8635431, PMID:8821376, PMID:15183516, PMID:17971868 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor increases expression
multiple interactions
increases response to substance
ISO
EXP
Pilocarpine results in increased expression of NGFR protein
Pilocarpine results in increased expression of NGFR mRNA; Pilocarpine results in increased expression of NGFR protein
PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein]
NGFR protein results in increased susceptibility to Pilocarpine
CTD PMID:10436046, PMID:12097334, PMID:18815271, PMID:21084616 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS1 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein] CTD PMID:18672383, PMID:20149694 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP [Pilocarpine co-treated with Lithium] results in increased expression of NOS2 protein; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]
Pilocarpine results in increased expression of NOS2 mRNA; Pilocarpine results in increased expression of NOS2 protein
CTD PMID:18672383, PMID:20149694, PMID:23211629 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nova1 NOVA alternative splicing regulator 1 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of NOVA1 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NOVA1 mRNA]
CTD PMID:20470870 NCBI chr 6:66,960,126...67,085,836
Ensembl chr 6:66,963,510...67,085,390
JBrowse link
G Nova2 NOVA alternative splicing regulator 2 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of NOVA2 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NOVA2 mRNA]
CTD PMID:20470870 NCBI chr 1:79,831,737...79,866,147
Ensembl chr 1:79,831,534...79,865,807
JBrowse link
G Nptx2 neuronal pentraxin 2 increases expression EXP Pilocarpine results in increased expression of NPTX2 mRNA CTD PMID:14656328 NCBI chr12:12,014,638...12,025,547
Ensembl chr12:12,013,911...12,025,549
JBrowse link
G Npy neuropeptide Y decreases response to substance
increases expression
ISO
EXP
NPY protein results in decreased susceptibility to Pilocarpine
Pilocarpine results in increased expression of NPY protein
CTD PMID:12231234, PMID:12821374, PMID:15451008 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Pilocarpine results in increased expression of NQO1 protein CTD PMID:32234387 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of NR3C1 protein] CTD PMID:32494933 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Pilocarpine results in decreased expression of NTF3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in decreased expression of NTF3 mRNA]
CTD PMID:8635431 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
increases expression
EXP Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA]; Pilocarpine promotes the reaction [BDNF protein results in decreased expression of NTRK2 protein]; Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] CTD PMID:8635431, PMID:8821376, PMID:15183516, PMID:19686240 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 increases expression
multiple interactions
EXP Pilocarpine results in increased expression of NTRK3 mRNA
Scopolamine inhibits the reaction [Pilocarpine results in increased expression of NTRK3 mRNA]
CTD PMID:8635431 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Pilocarpine results in increased expression of ODC1 mRNA CTD PMID:17971868 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression EXP Pilocarpine results in decreased expression of OGG1 mRNA; Pilocarpine results in decreased expression of OGG1 protein CTD PMID:20206232 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 protein results in decreased susceptibility to Pilocarpine CTD PMID:7894264 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 decreases expression EXP Pilocarpine results in decreased expression of OPRM1 protein CTD PMID:17919468 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Osm oncostatin M increases expression EXP Pilocarpine results in increased expression of OSM mRNA CTD PMID:10506506 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression EXP Pilocarpine results in increased expression of P2RX7 protein CTD PMID:19138473 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression
multiple interactions
EXP Pilocarpine affects the expression of PARP1 protein
3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; [Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] affects the expression of PARP1 protein]
CTD PMID:25101675, PMID:31396050 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Pilocarpine results in increased expression of PCNA mRNA CTD PMID:17971868 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression EXP Pilocarpine results in increased expression of PCSK1 mRNA CTD PMID:9015327 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 multiple interactions EXP [Pilocarpine co-treated with Lithium Chloride co-treated with 3-chloroacetylindole] results in decreased phosphorylation of PEA15 protein; [Pilocarpine co-treated with Lithium Chloride] results in decreased phosphorylation of PEA15 protein CTD PMID:31396050 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466
JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression ISO Pilocarpine results in increased expression of PLCB4 protein CTD PMID:18774262 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase increases expression EXP Pilocarpine results in increased expression of PNKP mRNA CTD PMID:17971868 NCBI chr 1:100,853,475...100,859,202
Ensembl chr 1:100,853,902...100,859,084
JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase increases expression EXP Pilocarpine results in increased expression of PNPO protein CTD PMID:19356691 NCBI chr10:84,874,926...84,881,190
Ensembl chr10:84,874,927...84,881,190
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression EXP Pilocarpine results in increased expression of POLG mRNA; Pilocarpine results in increased expression of POLG protein CTD PMID:20446108 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Pilocarpine results in increased expression of PPP1R15A protein CTD PMID:16492139 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Pilocarpine results in decreased expression of PPP3R1 mRNA CTD PMID:14656328 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Prkcb protein kinase C, beta increases expression
decreases expression
ISO
EXP
Pilocarpine results in increased expression of PRKCB protein
Pilocarpine results in decreased expression of PRKCB mRNA
CTD PMID:15058486, PMID:17971868, PMID:18774262 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta increases expression EXP Pilocarpine results in increased expression of PRKCD protein CTD PMID:15058486 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcg protein kinase C, gamma increases expression ISO
EXP
Pilocarpine results in increased expression of PRKCG protein CTD PMID:15058486, PMID:18774262 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Prkch protein kinase C, eta increases expression EXP Pilocarpine results in increased expression of PRKCH protein CTD PMID:15058486 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Pilocarpine results in increased expression of PRKCZ protein CTD PMID:15058486 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein] CTD PMID:21084616 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Pilocarpine results in increased expression of PTGES mRNA CTD PMID:15193289 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of PTGS2 mRNA
resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]
Pilocarpine results in increased expression of PTGS2 mRNA; Pilocarpine results in increased expression of PTGS2 protein
CTD PMID:15193289, PMID:23211629 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions
increases phosphorylation
ISO [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein
Pilocarpine results in increased phosphorylation of PTK2 protein
CTD PMID:10537051 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of PTK2B protein CTD PMID:16600505 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions
decreases response to substance
ISO PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTPN5 protein inhibits the reaction [Pilocarpine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PTPN5 protein mutant form results in decreased susceptibility to Pilocarpine
CTD PMID:17360923, PMID:21204826 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 affects expression EXP Pilocarpine affects the expression of PTPRZ1 protein CTD PMID:10582521 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Pvalb parvalbumin decreases expression EXP Pilocarpine results in decreased expression of PVALB protein CTD PMID:12183020 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Qdpr quinoid dihydropteridine reductase increases expression EXP Pilocarpine results in increased expression of QDPR protein CTD PMID:17366478 NCBI chr14:70,164,682...70,178,284
Ensembl chr14:70,164,650...70,178,284
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression
decreases expression
EXP Pilocarpine results in increased expression of RAD23A mRNA
Pilocarpine results in decreased expression of RAD23A mRNA
CTD PMID:17971868 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein increases expression EXP Pilocarpine results in increased expression of RAD23B mRNA CTD PMID:17971868 NCBI chr 5:72,103,704...72,141,701
Ensembl chr 5:72,103,704...72,141,700
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK mRNA; [Lithium Chloride co-treated with Pilocarpine] results in decreased expression of RECK protein CTD PMID:31018114 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 3-chloroacetylindole affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; [Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein; bisindolylmaleimide affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein]; U 0126 affects the reaction [[Pilocarpine co-treated with Lithium Chloride] results in increased phosphorylation of RELA protein] CTD PMID:31396050 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ret ret proto-oncogene multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased expression of RET protein CTD PMID:12914250 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G RGD1566085 similar to pyridoxal (pyridoxine, vitamin B6) kinase increases expression EXP Pilocarpine results in increased expression of PDXK protein CTD PMID:19356691 NCBI chr20:10,883,952...10,912,870
Ensembl chr20:10,889,573...10,912,769
JBrowse link
G Rpl32 ribosomal protein L32 multiple interactions ISO Pilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein] CTD PMID:16492139 NCBI chr 4:147,715,480...147,719,044
Ensembl chr 6:145,777,318...145,777,767
Ensembl chr 4:145,777,318...145,777,767
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
EXP dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]; Resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein] CTD PMID:23211629 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Pilocarpine results in increased expression of S100B protein CTD PMID:18226170 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases response to substance ISO SCN2B protein results in decreased susceptibility to Pilocarpine CTD PMID:12481039 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 increases expression EXP Pilocarpine results in increased expression of SCN8A mRNA; Pilocarpine results in increased expression of SCN8A protein CTD PMID:19306853 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
EXP dorsomorphin inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Niacinamide inhibits the reaction [Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]; Resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein] CTD PMID:23211629 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases expression ISO
EXP
Pilocarpine results in increased expression of SLC12A2 mRNA; Pilocarpine results in increased expression of SLC12A2 protein CTD PMID:18550034, PMID:19674083 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc12a5 solute carrier family 12 member 5 decreases expression
multiple interactions
increases degradation
ISO
EXP
Pilocarpine results in decreased expression of SLC12A5 mRNA; Pilocarpine results in decreased expression of SLC12A5 protein
Pilocarpine results in increased phosphorylation of and affects the localization of SLC12A5 protein
Pilocarpine results in increased degradation of SLC12A5 protein
CTD PMID:18094240, PMID:18550034, PMID:19674083, PMID:20600929 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression EXP Pilocarpine results in increased expression of SLC17A7 protein CTD PMID:17503488 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP Pilocarpine results in increased expression of SLC1A1 mRNA; Pilocarpine results in increased expression of SLC1A1 protein CTD PMID:11906504 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pilocarpine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc32a1 solute carrier family 32 member 1 increases expression EXP Pilocarpine results in increased expression of SLC32A1 mRNA; Pilocarpine results in increased expression of SLC32A1 protein CTD PMID:17503488 NCBI chr 3:155,102,980...155,107,815
Ensembl chr 3:155,103,150...155,107,817
JBrowse link
G Slc5a3 solute carrier family 5 member 3 increases response to substance
increases expression
affects response to substance
ISO SLC5A3 gene mutant form results in increased susceptibility to Pilocarpine
Pilocarpine results in increased expression of SLC5A3 mRNA
SLC5A3 protein affects the susceptibility to Pilocarpine
CTD PMID:17602744, PMID:19754464, PMID:21219332 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases expression EXP
ISO
Pilocarpine results in decreased expression of SLC6A1 protein
Pilocarpine results in decreased expression of SLC6A1 mRNA
CTD PMID:12183020, PMID:21219332 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
G Slc6a11 solute carrier family 6 member 11 decreases expression ISO Pilocarpine results in decreased expression of SLC6A11 mRNA CTD PMID:21219332 NCBI chr 4:146,106,386...146,223,228
Ensembl chr 4:146,106,386...146,223,228
JBrowse link
G Slc6a12 solute carrier family 6 member 12 decreases expression
increases expression
ISO Pilocarpine results in decreased expression of SLC6A12 mRNA
Pilocarpine results in increased expression of SLC6A12 mRNA
CTD PMID:21219332 NCBI chr 4:153,921,199...153,941,333
Ensembl chr 4:153,921,115...153,941,391
JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression ISO Pilocarpine results in increased expression of SLC6A6 mRNA CTD PMID:21219332 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP Pilocarpine results in decreased expression of SLCO1A4 protein CTD PMID:19570321 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slit2 slit guidance ligand 2 increases expression
decreases expression
EXP Pilocarpine results in increased expression of SLIT2 protein
Pilocarpine results in decreased expression of SLIT2 protein
CTD PMID:20153733 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Smc3 structural maintenance of chromosomes 3 increases expression EXP Pilocarpine results in increased expression of SMC3 mRNA CTD PMID:17971868 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Snta1 syntrophin, alpha 1 decreases expression EXP Pilocarpine results in decreased expression of SNTA1 protein CTD PMID:20886625 NCBI chr 3:149,874,023...149,905,980
Ensembl chr 3:149,874,030...149,905,944
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Pilocarpine results in increased expression of SOD2 protein CTD PMID:20446108 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sparcl1 SPARC like 1 affects localization
decreases expression
EXP Pilocarpine affects the localization of SPARCL1 protein
Pilocarpine results in decreased expression of SPARCL1 protein
CTD PMID:18488994, PMID:18808451 NCBI chr14:6,994,261...7,025,309
Ensembl chr14:6,994,190...7,025,308
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP [Lithium co-treated with Pilocarpine] results in increased activity of SRC protein CTD PMID:16600505 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Sstr1 somatostatin receptor 1 increases expression EXP Pilocarpine results in increased expression of SSTR1 protein CTD PMID:18951627 NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression EXP Pilocarpine results in increased expression of SSTR2 protein CTD PMID:18951627 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
JBrowse link
G Sstr3 somatostatin receptor 3 decreases expression EXP Pilocarpine results in decreased expression of SSTR3 protein CTD PMID:18951627 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Sstr4 somatostatin receptor 4 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of SSTR4 protein
Pilocarpine results in increased expression of SSTR4 protein
CTD PMID:18951627 NCBI chr 3:142,739,781...142,741,644
Ensembl chr 3:142,739,781...142,741,644
JBrowse link
G Sstr5 somatostatin receptor 5 decreases expression
increases expression
EXP Pilocarpine results in decreased expression of SSTR5 protein
Pilocarpine results in increased expression of SSTR5 protein
CTD PMID:18951627 NCBI chr10:14,847,749...14,853,827
Ensembl chr10:14,847,749...14,853,827
JBrowse link
G Star steroidogenic acute regulatory protein increases localization EXP Pilocarpine results in increased localization of STAR protein CTD PMID:20609383 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stard6 StAR-related lipid transfer domain containing 6 increases localization
increases expression
EXP Pilocarpine results in increased localization of STARD6 protein
Pilocarpine results in increased expression of STARD6 protein
CTD PMID:19434006, PMID:20609383 NCBI chr18:68,983,491...69,004,868
Ensembl chr18:68,983,545...69,000,993
JBrowse link
G Syp synaptophysin increases expression EXP Pilocarpine results in increased expression of SYP protein CTD PMID:16134595 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 mRNA; [Pilocarpine co-treated with Lithium] results in increased expression of TAC1 protein modified form; Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] CTD PMID:11074153 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tdg thymine-DNA glycosylase increases expression EXP Pilocarpine results in increased expression of TDG mRNA CTD PMID:17971868 NCBI chr 7:27,194,000...27,213,676
Ensembl chr 7:27,193,998...27,214,236
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Pilocarpine results in increased expression of TFAM mRNA; Pilocarpine results in increased expression of TFAM protein CTD PMID:20446108 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Thrb thyroid hormone receptor beta increases expression EXP Pilocarpine results in increased expression of THRB mRNA CTD PMID:14656328 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Pilocarpine results in increased expression of TIMP2 mRNA CTD PMID:14656328 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Pilocarpine results in decreased expression of TJP1 protein CTD PMID:17533168 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Pilocarpine results in increased expression of TLR2 mRNA CTD PMID:15193289 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of TLR4 mRNA] CTD PMID:32494933 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnc tenascin C increases expression EXP Pilocarpine results in increased expression of TNC mRNA CTD PMID:14656328 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
multiple interactions
ISO
EXP
Pilocarpine results in increased expression of TNF mRNA
Pilocarpine results in increased expression of TNF protein
Pilocarpine results in decreased expression of TNF mRNA; Pilocarpine results in decreased expression of TNF protein
[Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF mRNA; [Lithium Chloride co-treated with Pilocarpine] results in increased expression of TNF protein; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Pilocarpine results in increased expression of TNF protein]
CTD PMID:15193289, PMID:17872965, PMID:18455351, PMID:19055492, PMID:31018114 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Pilocarpine results in increased expression of TNFRSF1A mRNA CTD PMID:17971868 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Pilocarpine results in decreased expression of TNFSF10 mRNA CTD PMID:17971868 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression EXP Pilocarpine results in decreased expression of TNFSF13 mRNA CTD PMID:17971868 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tnr tenascin R increases expression EXP Pilocarpine results in increased expression of TNR protein CTD PMID:15120744 NCBI chr13:77,602,249...77,678,385
Ensembl chr13:77,485,113...77,678,437
JBrowse link
G Trex1 three prime repair exonuclease 1 increases expression EXP Pilocarpine results in increased expression of TREX1 mRNA CTD PMID:17971868 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Trh thyrotropin releasing hormone increases expression EXP Pilocarpine results in increased expression of TRH mRNA CTD PMID:10443546, PMID:15781040 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases activity
decreases expression
EXP Pilocarpine results in decreased activity of TRHR protein
Pilocarpine results in decreased expression of TRHR protein
CTD PMID:10443546 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 increases expression EXP Pilocarpine results in increased expression of UBE2D3 mRNA CTD PMID:17971868 NCBI chr 2:240,626,198...240,655,874
Ensembl chr 2:240,627,436...240,655,246
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression EXP Pilocarpine results in increased expression of UBE2I mRNA CTD PMID:17971868 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Vdr vitamin D receptor increases expression EXP Pilocarpine results in increased expression of VDR mRNA CTD PMID:18534255 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Pilocarpine results in increased expression of VEGFA protein CTD PMID:17533168 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible increases expression EXP Pilocarpine results in increased expression of VGF mRNA CTD PMID:14656328 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 increases expression EXP Pilocarpine results in increased expression of XRCC1 mRNA CTD PMID:17971868 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression EXP Pilocarpine results in increased expression of XRCC3 mRNA CTD PMID:17971868 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
G Zfp110 zinc finger protein 110 multiple interactions ISO ZFP110 protein mutant form inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein] CTD PMID:18815271 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528
JBrowse link
gamma-valerolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO gamma-valerolactone results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:70,421,599...70,447,109
Ensembl chr  X:70,426,951...70,428,364
JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19791
    chemical entity 19791
      group 19702
        inorganic group 19155
          oxo group 18410
            organic oxo compound 18410
              carbonyl compound 18410
                carboxylic ester 14348
                  lactone 5980
                    gamma-lactone 1216
                      butan-4-olide 307
                        (+)-garcinia acid 0
                        (+)-microdiplodiasone 0
                        (-)-5'-desmethylyatein 0
                        (-)-bursehernin + 0
                        (-)-pluviatolide + 0
                        (3R,4R)-3-[(1R)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one 0
                        (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one 0
                        (3R,4R)-3-acyl-4-(hydroxymethyl)oxolan-2-one + 0
                        (3R,4R)-4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one 0
                        (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)dihydrofuran-2-one 0
                        (R)-pantolactone 0
                        (S)-alpha-hydroxyglutaric acid-gamma-lactone 0
                        2-chloro-N-(2,6-dimethylphenyl)-N-(2-oxotetrahydrofuran-3-yl)acetamide + 0
                        20,21,22,23-tetrahydro-23-oxoazadirone 0
                        3-(2-bromoethyl)-5,5-dimethyldihydro-2(3H)-furanone 0
                        3-(2-chloroethyl)-5,5-dimethyldihydro-2(3H)-furanone 0
                        3-(3-bromopropyl)-5,5-dimethyldihydro-2-furanone 0
                        3-O-methyl-isosecotanapartholide 0
                        3-[(4-chlorophenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                        3-[(4-methoxyphenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                        3-[(4-nitrophenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                        3-[(phenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                        3-[2-(phenylsulfonyloxy)ethyl]-5,5-dimethyldihydro-2(3H)-furanone 0
                        3-[[(methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone 0
                        3-\{[1-(4-chlorophenylsulfonyl)oxy]ethyl\}-5,5-dimethyldihydro-2(3H)-furanone 0
                        3-\{[2-(4-methoxyphenylsulfonyl)oxy]ethyl\}-5,5-dimethyldihydro-2(3H)-furanone 0
                        3-acetyl-7-tigloylvilasinin lactone 0
                        3-bromomethyl-5,5-dimethylbutyrolactone 0
                        3-chloromethyl-5,5-dimethylbutyrolactone 0
                        3-hydroxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone 0
                        3-mesyloxymethyl-5,5-dimethylbutyrolactone 0
                        3-oxo-N-[(3S)-2-oxotetrahydrofuran-3-yl]octanamide 0
                        3-thiocyanatomethyl-5,5-dimethylbutyrolactone 0
                        3-tosyloxymethyl-5,5-dimethylbutyrolactone 0
                        4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one 0
                        4-(1-hydroxyethyl)-gamma-butanolactone 0
                        4-butyl-gamma-butyrolactone 0
                        5,5-dimethyl-3-(1-thiocyanatoethyl)dihydro-2(3H)-furanone 0
                        5,5-dimethyl-3-[2-(tosyloxy)ethyl]dihydro-2(3H)-furanone 0
                        5,5-dimethyl-3-\{[1-(4-nitrophenylsulfonyl)oxy]ethyl\}-dihydro-2(3H)-furanone 0
                        5,5-dimethyl-3-methylenedihydrofuran-2-one 0
                        5-(3',4',5'-trihydroxyphenyl)-gamma-valerolactone 0
                        5-(3',4'-dihydroxyphenyl)-gamma-valerolactone 3'-O-sulfate 0
                        5-(3'-hydroxyphenyl)-gamma-valerolactone-3'-O-beta-D-glucuronide 0
                        5-ethoxydihydro-2(3H)-furanone 0
                        D-ribono-1,4-lactone 0
                        D-threonolactone 0
                        L-threonolactone 0
                        N-[(3S)-2-oxotetrahydrofuran-3-yl]octanamide 0
                        N-acyl homoserine lactone + 5
                        [(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate 0
                        alpha'-angelica lactone 0
                        alpha-methylene gamma-butyrolactone + 0
                        anthecotulide 0
                        bihapten 1 0
                        bihapten 1 dimethyl ether 0
                        citrafungin A 0
                        citrafungin B 0
                        dihydroanhydropodorhizol 0
                        erythrono-1,4-lactone 0
                        gamma-butyrolactone + 0
                        gamma-caprolactone 0
                        gamma-nonanolactone 0
                        gamma-undecanolactone 0
                        gamma-valerolactone + 1
                        homoserine lactone + 5
                        isosecotanapartholide 0
                        lyratol D 0
                        seco-plakortolide K 0
                        seco-plakortolide L 0
                        seco-plakortolide O 0
                        seco-plakortolide P 0
                        tulipalin B 0
                        xi,xi-pilocarpine + 302
Path 2
Term Annotations click to browse term
  CHEBI ontology 19791
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19676
                    p-block element atom 19676
                      carbon group element atom 19579
                        carbon atom 19568
                          organic molecular entity 19568
                            organic group 18510
                              organic divalent group 18503
                                organodiyl group 18503
                                  carbonyl group 18410
                                    carbonyl compound 18410
                                      carboxylic ester 14348
                                        lactone 5980
                                          gamma-lactone 1216
                                            butan-4-olide 307
                                              (+)-garcinia acid 0
                                              (+)-microdiplodiasone 0
                                              (-)-5'-desmethylyatein 0
                                              (-)-bursehernin + 0
                                              (-)-pluviatolide + 0
                                              (3R,4R)-3-[(1R)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one 0
                                              (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one 0
                                              (3R,4R)-3-acyl-4-(hydroxymethyl)oxolan-2-one + 0
                                              (3R,4R)-4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one 0
                                              (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)dihydrofuran-2-one 0
                                              (R)-pantolactone 0
                                              (S)-alpha-hydroxyglutaric acid-gamma-lactone 0
                                              2-chloro-N-(2,6-dimethylphenyl)-N-(2-oxotetrahydrofuran-3-yl)acetamide + 0
                                              20,21,22,23-tetrahydro-23-oxoazadirone 0
                                              3-(2-bromoethyl)-5,5-dimethyldihydro-2(3H)-furanone 0
                                              3-(2-chloroethyl)-5,5-dimethyldihydro-2(3H)-furanone 0
                                              3-(3-bromopropyl)-5,5-dimethyldihydro-2-furanone 0
                                              3-O-methyl-isosecotanapartholide 0
                                              3-[(4-chlorophenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                                              3-[(4-methoxyphenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                                              3-[(4-nitrophenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                                              3-[(phenylsulfonyloxy)methyl]-5,5-dimethylbutyrolactone 0
                                              3-[2-(phenylsulfonyloxy)ethyl]-5,5-dimethyldihydro-2(3H)-furanone 0
                                              3-[[(methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone 0
                                              3-\{[1-(4-chlorophenylsulfonyl)oxy]ethyl\}-5,5-dimethyldihydro-2(3H)-furanone 0
                                              3-\{[2-(4-methoxyphenylsulfonyl)oxy]ethyl\}-5,5-dimethyldihydro-2(3H)-furanone 0
                                              3-acetyl-7-tigloylvilasinin lactone 0
                                              3-bromomethyl-5,5-dimethylbutyrolactone 0
                                              3-chloromethyl-5,5-dimethylbutyrolactone 0
                                              3-hydroxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone 0
                                              3-mesyloxymethyl-5,5-dimethylbutyrolactone 0
                                              3-oxo-N-[(3S)-2-oxotetrahydrofuran-3-yl]octanamide 0
                                              3-thiocyanatomethyl-5,5-dimethylbutyrolactone 0
                                              3-tosyloxymethyl-5,5-dimethylbutyrolactone 0
                                              4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one 0
                                              4-(1-hydroxyethyl)-gamma-butanolactone 0
                                              4-butyl-gamma-butyrolactone 0
                                              5,5-dimethyl-3-(1-thiocyanatoethyl)dihydro-2(3H)-furanone 0
                                              5,5-dimethyl-3-[2-(tosyloxy)ethyl]dihydro-2(3H)-furanone 0
                                              5,5-dimethyl-3-\{[1-(4-nitrophenylsulfonyl)oxy]ethyl\}-dihydro-2(3H)-furanone 0
                                              5,5-dimethyl-3-methylenedihydrofuran-2-one 0
                                              5-(3',4',5'-trihydroxyphenyl)-gamma-valerolactone 0
                                              5-(3',4'-dihydroxyphenyl)-gamma-valerolactone 3'-O-sulfate 0
                                              5-(3'-hydroxyphenyl)-gamma-valerolactone-3'-O-beta-D-glucuronide 0
                                              5-ethoxydihydro-2(3H)-furanone 0
                                              D-ribono-1,4-lactone 0
                                              D-threonolactone 0
                                              L-threonolactone 0
                                              N-[(3S)-2-oxotetrahydrofuran-3-yl]octanamide 0
                                              N-acyl homoserine lactone + 5
                                              [(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate 0
                                              alpha'-angelica lactone 0
                                              alpha-methylene gamma-butyrolactone + 0
                                              anthecotulide 0
                                              bihapten 1 0
                                              bihapten 1 dimethyl ether 0
                                              citrafungin A 0
                                              citrafungin B 0
                                              dihydroanhydropodorhizol 0
                                              erythrono-1,4-lactone 0
                                              gamma-butyrolactone + 0
                                              gamma-caprolactone 0
                                              gamma-nonanolactone 0
                                              gamma-undecanolactone 0
                                              gamma-valerolactone + 1
                                              homoserine lactone + 5
                                              isosecotanapartholide 0
                                              lyratol D 0
                                              seco-plakortolide K 0
                                              seco-plakortolide L 0
                                              seco-plakortolide O 0
                                              seco-plakortolide P 0
                                              tulipalin B 0
                                              xi,xi-pilocarpine + 302
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.