CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phenformin
Accession: CHEBI:8064
browse the term
Definition: A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis.
Synonyms: exact_synonym: N-(2-phenylethyl)imidodicarbonimidic diamide
related_synonym: DBI; Formula=C10H15N5; InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15); InChIKey=ICFJFFQQTFMIBG-UHFFFAOYSA-N; SMILES=NC(=N)NC(=N)NCCC1=CC=CC=C1; fenformina; phenformine; phenforminum
xref: CAS:114-86-3; DrugBank:DB00914; Drug_Central:2126; HMDB:HMDB0015050; KEGG:C07673; KEGG:D08351; LINCS:LSM-2233
xref_mesh: MESH:D010629
xref: PDBeChem:8CV; PMID:16567854; PMID:18239244; PMID:20188727; PMID:21084729; PMID:22036620; PMID:22361631; PMID:23322141; PMID:23475884; PMID:23548904; PMID:23612073; PMID:28766937; PMID:7390164; Patent:US2961377; Patent:US3057780; Patent:WO2010114805; Reaxys:1977317; Wikipedia:Phenformin
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A2m
alpha-2-macroglobulin
decreases expression
EXP
Phenformin results in decreased expression of A2M mRNA
CTD
PMID:31324951
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Abcb4
ATP binding cassette subfamily B member 4
increases expression
EXP
Phenformin results in increased expression of ABCB4 mRNA
CTD
PMID:31324951
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Phenformin results in increased expression of ABCC3 mRNA
CTD
PMID:31324951
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcd2
ATP binding cassette subfamily D member 2
increases expression
EXP
Phenformin results in increased expression of ABCD2 mRNA
CTD
PMID:31324951
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
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Abcg2
ATP binding cassette subfamily G member 2
decreases expression
EXP
Phenformin results in decreased expression of ABCG2 mRNA
CTD
PMID:31324951
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abcg5
ATP binding cassette subfamily G member 5
increases expression
EXP
Phenformin results in increased expression of ABCG5 mRNA
CTD
PMID:31324951
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Abcg8
ATP binding cassette subfamily G member 8
increases expression
EXP
Phenformin results in increased expression of ABCG8 mRNA
CTD
PMID:31324951
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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Abra
actin-binding Rho activating protein
decreases expression
EXP
Phenformin results in decreased expression of ABRA mRNA
CTD
PMID:31324951
NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:72,970,186...72,974,255
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Acaca
acetyl-CoA carboxylase alpha
decreases expression
EXP
Phenformin results in decreased expression of ACACA mRNA
CTD
PMID:31324951
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Ackr3
atypical chemokine receptor 3
decreases expression
EXP
Phenformin results in decreased expression of ACKR3 mRNA
CTD
PMID:31324951
NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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Acly
ATP citrate lyase
decreases expression
EXP
Phenformin results in decreased expression of ACLY mRNA
CTD
PMID:31324951
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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Acmsd
aminocarboxymuconate semialdehyde decarboxylase
increases expression
EXP
Phenformin results in increased expression of ACMSD mRNA
CTD
PMID:31324951
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
EXP
Phenformin results in decreased expression of ACSL3 mRNA
CTD
PMID:31324951
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Actg1
actin, gamma 1
decreases expression
EXP
Phenformin results in decreased expression of ACTG1 mRNA
CTD
PMID:31324951
NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232 Ensembl chr 3:105,619,737...105,624,232
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
decreases expression
EXP
Phenformin results in decreased expression of ADAMTS1 mRNA
CTD
PMID:31324951
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
increases expression
EXP
Phenformin results in increased expression of ADH4 mRNA
CTD
PMID:31324951
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Adh6
alcohol dehydrogenase 6 (class V)
increases expression
EXP
Phenformin results in increased expression of ADH6 mRNA
CTD
PMID:31324951
NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534
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Afmid
arylformamidase
decreases expression
EXP
Phenformin results in decreased expression of AFMID mRNA
CTD
PMID:31324951
NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718
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Agxt
alanine--glyoxylate aminotransferase
increases expression
EXP
Phenformin results in increased expression of AGXT mRNA
CTD
PMID:31324951
NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
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Akr1b8-ps2
aldo-keto reductase family 1, member B8, pseudogene 2
decreases expression
EXP
Phenformin results in decreased expression of AKR1B8-PS2 mRNA
CTD
PMID:31324951
NCBI chr 6:77,569,720...77,571,967
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
Phenformin results in increased phosphorylation of AKT1 protein
CTD
PMID:19901985
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alas2
5'-aminolevulinate synthase 2
decreases expression
EXP
Phenformin results in decreased expression of ALAS2 mRNA
CTD
PMID:31324951
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
Phenformin results in increased expression of ALDH1A1 mRNA
CTD
PMID:31324951
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Alox15
arachidonate 15-lipoxygenase
decreases expression
EXP
Phenformin results in decreased expression of ALOX15 mRNA
CTD
PMID:31324951
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Amacr
alpha-methylacyl-CoA racemase
increases expression
EXP
Phenformin results in increased expression of AMACR mRNA
CTD
PMID:31324951
NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
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Amdhd1
amidohydrolase domain containing 1
increases expression
EXP
Phenformin results in increased expression of AMDHD1 mRNA
CTD
PMID:31324951
NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156
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Angptl4
angiopoietin-like 4
affects expression
EXP
Phenformin affects the expression of ANGPTL4 mRNA
CTD
PMID:31324951
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Angptl8
angiopoietin-like 8
decreases expression
EXP
Phenformin results in decreased expression of ANGPTL8 mRNA
CTD
PMID:31324951
NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
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Ankh
ANKH inorganic pyrophosphate transport regulator
decreases expression
EXP
Phenformin results in decreased expression of ANKH mRNA
CTD
PMID:31324951
NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187
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Anlnl1
anillin, actin binding protein-like 1
decreases expression
EXP
Phenformin results in decreased expression of ANLNL1 mRNA
CTD
PMID:31324951
NCBI chr17:57,985,340...57,995,824
Ensembl chr17:57,986,511...57,989,997
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Ano5
anoctamin 5
decreases expression
EXP
Phenformin results in decreased expression of ANO5 mRNA
CTD
PMID:31324951
NCBI chr 1:101,086,490...101,187,547
Ensembl chr 1:101,087,341...101,187,555
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Apcdd1
APC down-regulated 1
increases expression
EXP
Phenformin results in increased expression of APCDD1 mRNA
CTD
PMID:31324951
NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070
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Aph1b
aph-1 homolog B, gamma secretase subunit
decreases expression
EXP
Phenformin results in decreased expression of APH1B mRNA
CTD
PMID:31324951
NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
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Aplnr
apelin receptor
increases expression
EXP
Phenformin results in increased expression of APLNR mRNA
CTD
PMID:31324951
NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
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Apoa4
apolipoprotein A4
decreases expression
EXP
Phenformin results in decreased expression of APOA4 mRNA
CTD
PMID:31324951
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoc4
apolipoprotein C4
increases expression
EXP
Phenformin results in increased expression of APOC4 mRNA
CTD
PMID:31324951
NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981
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Apof
apolipoprotein F
increases expression
EXP
Phenformin results in increased expression of APOF mRNA
CTD
PMID:31324951
NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
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Apold1
apolipoprotein L domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of APOLD1 mRNA
CTD
PMID:31324951
NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706
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Aqp7
aquaporin 7
increases expression
EXP
Phenformin results in increased expression of AQP7 mRNA
CTD
PMID:31324951
NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
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Aqp9
aquaporin 9
increases expression
EXP
Phenformin results in increased expression of AQP9 mRNA
CTD
PMID:31324951
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Ar
androgen receptor
decreases expression
EXP
Phenformin results in decreased expression of AR mRNA
CTD
PMID:31324951
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arhgap11a
Rho GTPase activating protein 11A
decreases expression
EXP
Phenformin results in decreased expression of ARHGAP11A mRNA
CTD
PMID:31324951
NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
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Arrdc4
arrestin domain containing 4
increases expression
EXP
Phenformin results in increased expression of ARRDC4 mRNA
CTD
PMID:31324951
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
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Asl
argininosuccinate lyase
increases expression
EXP
Phenformin results in increased expression of ASL mRNA
CTD
PMID:31324951
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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Aspm
assembly factor for spindle microtubules
decreases expression
EXP
Phenformin results in decreased expression of ASPM mRNA
CTD
PMID:31324951
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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Aspn
asporin
decreases expression
EXP
Phenformin results in decreased expression of ASPN mRNA
CTD
PMID:31324951
NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
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Atf3
activating transcription factor 3
decreases expression
EXP
Phenformin results in decreased expression of ATF3 mRNA
CTD
PMID:31324951
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Aurkb
aurora kinase B
decreases expression
EXP
Phenformin results in decreased expression of AURKB mRNA
CTD
PMID:31324951
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Bex2
brain expressed X-linked 2
increases expression
EXP
Phenformin results in increased expression of BEX1 mRNA
CTD
PMID:31324951
NCBI chr X:99,019,847...99,021,375
Ensembl chr X:99,019,000...99,021,503
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Bhlhe40
basic helix-loop-helix family, member e40
decreases expression
EXP
Phenformin results in decreased expression of BHLHE40 mRNA
CTD
PMID:31324951
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Btg2
BTG anti-proliferation factor 2
decreases expression
EXP
Phenformin results in decreased expression of BTG2 mRNA
CTD
PMID:31324951
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
decreases expression
EXP
Phenformin results in decreased expression of BUB1 mRNA
CTD
PMID:31324951
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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C8h11orf54
similar to human chromosome 11 open reading frame 54
decreases expression
EXP
Phenformin results in decreased expression of C8H11ORF54 mRNA
CTD
PMID:31324951
NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473
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Car5a
carbonic anhydrase 5A
increases expression
EXP
Phenformin results in increased expression of CAR5A mRNA
CTD
PMID:31324951
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
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Car5b
carbonic anhydrase 5B
decreases expression
EXP
Phenformin results in decreased expression of CAR5B mRNA
CTD
PMID:31324951
NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
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Ccdc141
coiled-coil domain containing 141
decreases expression
EXP
Phenformin results in decreased expression of CCDC141 mRNA
CTD
PMID:31324951
NCBI chr 3:61,948,614...62,109,968
Ensembl chr 3:61,948,646...62,110,079
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Ccdc38
coiled-coil domain containing 38
increases expression
EXP
Phenformin results in increased expression of CCDC38 mRNA
CTD
PMID:31324951
NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441
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Ccdc77
coiled-coil domain containing 77
increases expression
EXP
Phenformin results in increased expression of CCDC77 mRNA
CTD
PMID:31324951
NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545
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Ccl2
C-C motif chemokine ligand 2
decreases expression
EXP
Phenformin results in decreased expression of CCL2 mRNA
CTD
PMID:31324951
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccn2
cellular communication network factor 2
decreases expression
EXP
Phenformin results in decreased expression of CCN2 mRNA
CTD
PMID:31324951
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccna2
cyclin A2
decreases expression
EXP
Phenformin results in decreased expression of CCNA2 mRNA
CTD
PMID:31324951
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
EXP
Phenformin results in decreased expression of CCNB1 mRNA
CTD
PMID:31324951
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnb2
cyclin B2
affects expression
EXP
Phenformin affects the expression of CCNB2 mRNA
CTD
PMID:31324951
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccnd1
cyclin D1
increases expression
EXP
Phenformin results in increased expression of CCND1 mRNA
CTD
PMID:31324951
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne2
cyclin E2
decreases expression
EXP
Phenformin results in decreased expression of CCNE2 mRNA
CTD
PMID:31324951
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cd226
CD226 molecule
decreases expression
EXP
Phenformin results in decreased expression of CD226 mRNA
CTD
PMID:31324951
NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051
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Cd274
CD274 molecule
increases expression
EXP
Phenformin results in increased expression of CD274 mRNA
CTD
PMID:31324951
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd5l
Cd5 molecule-like
increases expression
EXP
Phenformin results in increased expression of CD5L mRNA
CTD
PMID:31324951
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
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Cd63
Cd63 molecule
increases expression
EXP
Phenformin results in increased expression of CD63 mRNA
CTD
PMID:31324951
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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Cd74
CD74 molecule
increases expression
EXP
Phenformin results in increased expression of CD74 mRNA
CTD
PMID:31324951
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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Cdc20
cell division cycle 20
decreases expression
EXP
Phenformin results in decreased expression of CDC20 mRNA
CTD
PMID:31324951
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdk1
cyclin-dependent kinase 1
decreases expression
EXP
Phenformin results in decreased expression of CDK1 mRNA
CTD
PMID:31324951
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression decreases expression
ISO EXP
Phenformin results in increased expression of CDKN1A protein Phenformin results in decreased expression of CDKN1A mRNA
CTD
PMID:14623034 PMID:31324951
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
EXP
Phenformin results in decreased expression of CDKN3 mRNA
CTD
PMID:31324951
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cemip2
cell migration inducing hyaluronidase 2
decreases expression
EXP
Phenformin results in decreased expression of CEMIP2 mRNA
CTD
PMID:31324951
NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
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Cenpe
centromere protein E
decreases expression
EXP
Phenformin results in decreased expression of CENPE mRNA
CTD
PMID:31324951
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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Cenpf
centromere protein F
decreases expression
EXP
Phenformin results in decreased expression of CENPF mRNA
CTD
PMID:31324951
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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Ces2c
carboxylesterase 2C
increases expression
EXP
Phenformin results in increased expression of CES2C mRNA
CTD
PMID:31324951
NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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Ces4a
carboxylesterase 4A
decreases expression
EXP
Phenformin results in decreased expression of CES4A mRNA
CTD
PMID:31324951
NCBI chr19:33,011,731...33,030,119
Ensembl chr19:33,011,731...33,029,545
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Chka
choline kinase alpha
decreases expression
EXP
Phenformin results in decreased expression of CHKA mRNA
CTD
PMID:31324951
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
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Cish
cytokine inducible SH2-containing protein
decreases expression
EXP
Phenformin results in decreased expression of CISH mRNA
CTD
PMID:31324951
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
G
Ckap2
cytoskeleton associated protein 2
decreases expression
EXP
Phenformin results in decreased expression of CKAP2 mRNA
CTD
PMID:31324951
NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
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Cks2
CDC28 protein kinase regulatory subunit 2
decreases expression
EXP
Phenformin results in decreased expression of CKS2 mRNA
CTD
PMID:31324951
NCBI chr17:13,570,611...13,575,770
G
Clec1a
C-type lectin domain family 1, member A
decreases expression
EXP
Phenformin results in decreased expression of CLEC1A mRNA
CTD
PMID:31324951
NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247
G
Clec1b
C-type lectin domain family 1, member B
decreases expression
EXP
Phenformin results in decreased expression of CLEC1B mRNA
CTD
PMID:31324951
NCBI chr 4:162,847,978...162,856,291
Ensembl chr 4:162,848,010...162,856,291
G
Cpne8
copine 8
increases expression
EXP
Phenformin results in increased expression of CPNE8 mRNA
CTD
PMID:31324951
NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
G
Cpt1a
carnitine palmitoyltransferase 1A
increases expression
EXP
Phenformin results in increased expression of CPT1A mRNA
CTD
PMID:31324951
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Crat
carnitine O-acetyltransferase
increases expression
EXP
Phenformin results in increased expression of CRAT mRNA
CTD
PMID:31324951
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Crot
carnitine O-octanoyltransferase
increases expression
EXP
Phenformin results in increased expression of CROT mRNA
CTD
PMID:31324951
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
G
Cry1
cryptochrome circadian regulator 1
decreases expression
EXP
Phenformin results in decreased expression of CRY1 mRNA
CTD
PMID:31324951
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
G
Cryl1
crystallin, lambda 1
increases expression
EXP
Phenformin results in increased expression of CRYL1 mRNA
CTD
PMID:31324951
NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
G
Csad
cysteine sulfinic acid decarboxylase
decreases expression
EXP
Phenformin results in decreased expression of CSAD mRNA
CTD
PMID:31324951
NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
G
Csrp1
cysteine and glycine-rich protein 1
decreases expression
EXP
Phenformin results in decreased expression of CSRP1 mRNA
CTD
PMID:31324951
NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
G
Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
EXP
Phenformin results in decreased expression of CXCL1 mRNA
CTD
PMID:31324951
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
G
Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
EXP
Phenformin results in decreased expression of CXCL10 mRNA
CTD
PMID:31324951
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
EXP
Phenformin results in increased expression of CXCR4 mRNA
CTD
PMID:31324951
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
EXP
Phenformin results in decreased expression of CYP17A1 mRNA
CTD
PMID:31324951
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Phenformin results in increased expression of CYP2B1 mRNA
CTD
PMID:31324951
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
decreases expression
EXP
Phenformin results in decreased expression of CYP2C12 mRNA
CTD
PMID:31324951
NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
G
Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
increases expression
EXP
Phenformin results in increased expression of CYP2C24 mRNA
CTD
PMID:31324951
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Phenformin results in increased expression of CYP2E1 mRNA
CTD
PMID:31324951
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
increases expression
EXP
Phenformin results in increased expression of CYP3A18 mRNA
CTD
PMID:31324951
NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
G
Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
increases expression
EXP
Phenformin results in increased expression of CYP4A1 mRNA
CTD
PMID:31324951
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
G
Cyp4a2
cytochrome P450, family 4, subfamily a, polypeptide 2
increases expression
EXP
Phenformin results in increased expression of CYP4A2 mRNA
CTD
PMID:31324951
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
EXP
Phenformin results in decreased expression of CYP7A1 mRNA
CTD
PMID:31324951
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
increases expression
EXP
Phenformin results in increased expression of CYP8B1 mRNA
CTD
PMID:31324951
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
Phenformin results in increased expression of DBP mRNA
CTD
PMID:31324951
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
G
Dcn
decorin
decreases expression
EXP
Phenformin results in decreased expression of DCN mRNA
CTD
PMID:31324951
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
G
Ddhd1
DDHD domain containing 1
increases expression
EXP
Phenformin results in increased expression of DDHD1 mRNA
CTD
PMID:31324951
NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
G
Ddit4
DNA-damage-inducible transcript 4
decreases expression
EXP
Phenformin results in decreased expression of DDIT4 mRNA
CTD
PMID:31324951
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
G
Decr1
2,4-dienoyl-CoA reductase 1
increases expression
EXP
Phenformin results in increased expression of DECR1 mRNA
CTD
PMID:31324951
NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
G
Depdc1
DEP domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of DEPDC1 mRNA
CTD
PMID:31324951
NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951
G
Diaph3
diaphanous-related formin 3
decreases expression
EXP
Phenformin results in decreased expression of DIAPH3 mRNA
CTD
PMID:31324951
NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
G
Dio1
iodothyronine deiodinase 1
decreases expression
EXP
Phenformin results in decreased expression of DIO1 mRNA
CTD
PMID:31324951
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
G
Dmbt1
deleted in malignant brain tumors 1
increases expression
EXP
Phenformin results in increased expression of DMBT1 mRNA
CTD
PMID:31324951
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
G
Dmxl2
Dmx-like 2
decreases expression
EXP
Phenformin results in decreased expression of DMXL2 mRNA
CTD
PMID:31324951
NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161
G
Dusp1
dual specificity phosphatase 1
decreases expression
EXP
Phenformin results in decreased expression of DUSP1 mRNA
CTD
PMID:31324951
NCBI chr10:16,680,478...16,683,275
G
Ech1
enoyl-CoA hydratase 1
increases expression
EXP
Phenformin results in increased expression of ECH1 mRNA
CTD
PMID:31324951
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
G
Eci1
enoyl-CoA delta isomerase 1
increases expression
EXP
Phenformin results in increased expression of ECI1 mRNA
CTD
PMID:31324951
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
G
Ect2
epithelial cell transforming 2
decreases expression
EXP
Phenformin results in decreased expression of ECT2 mRNA
CTD
PMID:31324951
NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
G
Edem1
ER degradation enhancing alpha-mannosidase like protein 1
decreases expression
EXP
Phenformin results in decreased expression of EDEM1 mRNA
CTD
PMID:31324951
NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
G
Edil3
EGF like repeats and discoidin domains 3
decreases expression
EXP
Phenformin results in decreased expression of EDIL3 mRNA
CTD
PMID:31324951
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
G
Egr1
early growth response 1
decreases expression
EXP
Phenformin results in decreased expression of EGR1 mRNA
CTD
PMID:31324951
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Ell2
elongation factor for RNA polymerase II 2
decreases expression
EXP
Phenformin results in decreased expression of ELL2 mRNA
CTD
PMID:31324951
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
G
Elovl2
ELOVL fatty acid elongase 2
increases expression
EXP
Phenformin results in increased expression of ELOVL2 mRNA
CTD
PMID:31324951
NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848
G
Elovl6
ELOVL fatty acid elongase 6
decreases expression
EXP
Phenformin results in decreased expression of ELOVL6 mRNA
CTD
PMID:31324951
NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
G
Erich5
glutamate-rich 5
decreases expression
EXP
Phenformin results in decreased expression of ERICH5 mRNA
CTD
PMID:31324951
NCBI chr 7:65,655,829...65,682,221
Ensembl chr 7:65,657,204...65,680,207
G
Errfi1
ERBB receptor feedback inhibitor 1
decreases expression
EXP
Phenformin results in decreased expression of ERRFI1 mRNA
CTD
PMID:31324951
NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
G
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
decreases expression
EXP
Phenformin results in decreased expression of ESCO2 mRNA
CTD
PMID:31324951
NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
G
Esm1
endothelial cell-specific molecule 1
increases expression
EXP
Phenformin results in increased expression of ESM1 mRNA
CTD
PMID:31324951
NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
G
F2rl2
coagulation factor II (thrombin) receptor-like 2
decreases expression
EXP
Phenformin results in decreased expression of F2RL2 mRNA
CTD
PMID:31324951
NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098
G
F3
coagulation factor III, tissue factor
decreases expression
EXP
Phenformin results in decreased expression of F3 mRNA
CTD
PMID:31324951
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Fabp5
fatty acid binding protein 5
decreases expression
EXP
Phenformin results in decreased expression of FABP5 mRNA
CTD
PMID:31324951
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
G
Fam111a
FAM111 trypsin like peptidase A
decreases expression
EXP
Phenformin results in decreased expression of FAM111A mRNA
CTD
PMID:31324951
NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547
G
Fam117b
family with sequence similarity 117, member B
increases expression
EXP
Phenformin results in increased expression of FAM117B mRNA
CTD
PMID:31324951
NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483
G
Fam149a
family with sequence similarity 149, member A
decreases expression
EXP
Phenformin results in decreased expression of FAM149A mRNA
CTD
PMID:31324951
NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066
G
Fam83d
family with sequence similarity 83, member D
decreases expression
EXP
Phenformin results in decreased expression of FAM83D mRNA
CTD
PMID:31324951
NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
G
Fasn
fatty acid synthase
decreases expression
EXP
Phenformin results in decreased expression of FASN mRNA
CTD
PMID:31324951
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
G
Fgf6
fibroblast growth factor 6
increases expression
EXP
Phenformin results in increased expression of MT1F mRNA
CTD
PMID:31324951
NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
G
Fmo2
flavin containing dimethylaniline monoxygenase 2
decreases expression
EXP
Phenformin results in decreased expression of FMO2 mRNA
CTD
PMID:31324951
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
G
Fmo5
flavin containing dimethylaniline monoxygenase 5
increases expression
EXP
Phenformin results in increased expression of FMO5 mRNA
CTD
PMID:31324951
NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Phenformin results in decreased expression of FOS mRNA
CTD
PMID:31324951
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxa1
forkhead box A1
decreases expression
EXP
Phenformin results in decreased expression of FOXA1 mRNA
CTD
PMID:31324951
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
G
Foxa2
forkhead box A2
decreases expression
EXP
Phenformin results in decreased expression of FOXA2 mRNA
CTD
PMID:31324951
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
G
Foxo3
forkhead box O3
decreases expression
EXP
Phenformin results in decreased expression of FOXO3 mRNA
CTD
PMID:31324951
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Fpr1
formyl peptide receptor 1
decreases expression
EXP
Phenformin results in decreased expression of FPR1 mRNA
CTD
PMID:31324951
NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
G
Fras1
Fraser extracellular matrix complex subunit 1
decreases expression
EXP
Phenformin results in decreased expression of FRAS1 mRNA
CTD
PMID:31324951
NCBI chr14:12,791,407...13,200,862
Ensembl chr14:12,793,599...13,200,726
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
EXP
Phenformin results in decreased expression of G6PC1 mRNA
CTD
PMID:31324951
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
Gadd45g
growth arrest and DNA-damage-inducible, gamma
decreases expression
EXP
Phenformin results in decreased expression of GADD45G mRNA
CTD
PMID:31324951
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
G
Gbe1
1,4-alpha-glucan branching enzyme 1
decreases expression
EXP
Phenformin results in decreased expression of GBE1 mRNA
CTD
PMID:31324951
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
G
Gbp1
guanylate binding protein 1
increases expression
EXP
Phenformin results in increased expression of GBP1 mRNA
CTD
PMID:31324951
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
G
Gbp1-ps1
guanylate binding protein 1, pseudogene 1
increases expression
EXP
Phenformin results in increased expression of GBP1-PS1 mRNA
CTD
PMID:31324951
NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:231,517,398...231,529,600
G
Gck
glucokinase
decreases expression
EXP
Phenformin results in decreased expression of GCK mRNA
CTD
PMID:31324951
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
G
Gimd1
GIMAP family P-loop NTPase domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of GIMD1 mRNA
CTD
PMID:31324951
NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553
G
Gk
glycerol kinase
increases expression
EXP
Phenformin results in increased expression of GK mRNA
CTD
PMID:31324951
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
G
Gnmt
glycine N-methyltransferase
increases expression
EXP
Phenformin results in increased expression of GNMT mRNA
CTD
PMID:31324951
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
G
Got1
glutamic-oxaloacetic transaminase 1
increases expression
EXP
Phenformin results in increased expression of GOT1 mRNA
CTD
PMID:31324951
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
G
Gp5
glycoprotein V (platelet)
decreases expression
EXP
Phenformin results in decreased expression of GP5 mRNA
CTD
PMID:31324951
NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
G
Gpa33
glycoprotein A33
increases expression
EXP
Phenformin results in increased expression of GPA33 mRNA
CTD
PMID:31324951
NCBI chr13:78,381,141...78,414,765
Ensembl chr13:78,381,141...78,414,765
G
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
EXP
Phenformin results in increased expression of GPAM mRNA
CTD
PMID:31324951
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
EXP
Phenformin results in increased expression of GPAT3 mRNA
CTD
PMID:31324951
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
G
Gpd2
glycerol-3-phosphate dehydrogenase 2
increases expression
EXP
Phenformin results in increased expression of GPD2 mRNA
CTD
PMID:31324951
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
G
Gpnmb
glycoprotein nmb
increases expression
EXP
Phenformin results in increased expression of GPNMB mRNA
CTD
PMID:31324951
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
G
Gprin3
GPRIN family member 3
decreases expression
EXP
Phenformin results in decreased expression of GPRIN3 mRNA
CTD
PMID:31324951
NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:88,563,607...88,657,429
G
Gpt
glutamic--pyruvic transaminase
increases expression
EXP
Phenformin results in increased expression of GPT mRNA
CTD
PMID:31324951
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx2-ps2
glutathione peroxidase 2, pseudogene 2
affects expression
EXP
Phenformin affects the expression of GPX2-PS2 mRNA
CTD
PMID:31324951
NCBI chr X:59,444,660...59,445,203
G
Gstm2
glutathione S-transferase mu 2
increases expression
EXP
Phenformin results in increased expression of GSTM2 mRNA
CTD
PMID:31324951
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstm4
glutathione S-transferase mu 4
increases expression
EXP
Phenformin results in increased expression of GSTM4 mRNA
CTD
PMID:31324951
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
G
Gstz1
glutathione S-transferase zeta 1
increases expression
EXP
Phenformin results in increased expression of GSTZ1 mRNA
CTD
PMID:31324951
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
G
Gypa
glycophorin A
decreases expression
EXP
Phenformin results in decreased expression of GYPA mRNA
CTD
PMID:31324951
NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
G
H2ac4
H2A clustered histone 4
decreases expression
EXP
Phenformin results in decreased expression of H2AC4 mRNA
CTD
PMID:31324951
NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381
G
H2ax
H2A.X variant histone
decreases expression
EXP
Phenformin results in decreased expression of H2AX mRNA
CTD
PMID:31324951
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hamp
hepcidin antimicrobial peptide
decreases expression
EXP
Phenformin results in decreased expression of HAMP mRNA
CTD
PMID:31324951
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Hbb
hemoglobin subunit beta
decreases expression
EXP
Phenformin results in decreased expression of HBB-B1 mRNA
CTD
PMID:31324951
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Hhex
hematopoietically expressed homeobox
decreases expression
EXP
Phenformin results in decreased expression of HHEX mRNA
CTD
PMID:31324951
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
G
Hif1a
hypoxia inducible factor 1 subunit alpha
increases expression
ISO
Phenformin results in increased expression of HIF1A protein
CTD
PMID:26768367
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hist1h2af
histone cluster 1 H2A family member F
decreases expression
EXP
Phenformin results in decreased expression of HIST1H2AF mRNA
CTD
PMID:31324951
NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796
G
Hist1h2ail1
histone cluster 1 H2a family member I like 1
decreases expression
EXP
Phenformin results in decreased expression of HIST1H2AIL1 mRNA
CTD
PMID:31324951
NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109
G
Hist2h3c2
histone cluster 2 H3 family member C2
decreases expression
EXP
Phenformin results in decreased expression of HIST2H3C2 mRNA
CTD
PMID:31324951
NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752
G
Hlf
HLF transcription factor, PAR bZIP family member
decreases expression
EXP
Phenformin results in decreased expression of HLF mRNA
CTD
PMID:31324951
NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
EXP
Phenformin results in decreased expression of HMGCR mRNA
CTD
PMID:31324951
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmmr
hyaluronan-mediated motility receptor
decreases expression
EXP
Phenformin results in decreased expression of HMMR mRNA
CTD
PMID:31324951
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
increases expression
EXP
Phenformin results in increased expression of HSD17B2 mRNA
CTD
PMID:31324951
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
decreases expression
EXP
Phenformin results in decreased expression of HSP90AA1 mRNA
CTD
PMID:31324951
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hspa4l
heat shock protein family A (Hsp70) member 4 like
decreases expression
EXP
Phenformin results in decreased expression of HSPA4L mRNA
CTD
PMID:31324951
NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
G
Hykk
hydroxylysine kinase
increases expression
EXP
Phenformin results in increased expression of HYKK mRNA
CTD
PMID:31324951
NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
G
Ier2
immediate early response 2
decreases expression
EXP
Phenformin results in decreased expression of IER2 mRNA
CTD
PMID:31324951
NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211
G
Ifgga4l
interferon-gamma-inducible GTPase 4 like
increases expression
EXP
Phenformin results in increased expression of IFGGA4L mRNA
CTD
PMID:31324951
NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696
G
Ifitm3
interferon induced transmembrane protein 3
increases expression
EXP
Phenformin results in increased expression of IFITM3 mRNA
CTD
PMID:31324951
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
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Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
decreases expression
EXP
Phenformin results in decreased expression of IGF2BP3 mRNA
CTD
PMID:31324951
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
G
Igfals
insulin-like growth factor binding protein, acid labile subunit
decreases expression
EXP
Phenformin results in decreased expression of IGFALS mRNA
CTD
PMID:31324951
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
G
Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
Phenformin results in increased expression of IGFBP2 mRNA
CTD
PMID:31324951
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
G
Igfbp5
insulin-like growth factor binding protein 5
decreases expression
EXP
Phenformin results in decreased expression of IGFBP5 mRNA
CTD
PMID:31324951
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
G
Il1r1
interleukin 1 receptor type 1
increases expression
EXP
Phenformin results in increased expression of IL1R1 mRNA
CTD
PMID:31324951
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
G
Il33
interleukin 33
increases expression
EXP
Phenformin results in increased expression of IL33 mRNA
CTD
PMID:31324951
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Inha
inhibin subunit alpha
decreases expression
EXP
Phenformin results in decreased expression of INHA mRNA
CTD
PMID:31324951
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
G
Inhba
inhibin subunit beta A
decreases expression
EXP
Phenformin results in decreased expression of INHBA mRNA
CTD
PMID:31324951
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
G
Inhbe
inhibin subunit beta E
increases expression
EXP
Phenformin results in increased expression of INHBE mRNA
CTD
PMID:31324951
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Inmt
indolethylamine N-methyltransferase
increases expression
EXP
Phenformin results in increased expression of INMT mRNA
CTD
PMID:31324951
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Insig1
insulin induced gene 1
decreases expression
EXP
Phenformin results in decreased expression of INSIG1 mRNA
CTD
PMID:31324951
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
G
Insig2
insulin induced gene 2
increases expression
EXP
Phenformin results in increased expression of INSIG2 mRNA
CTD
PMID:31324951
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Ip6k2
inositol hexakisphosphate kinase 2
decreases expression
EXP
Phenformin results in decreased expression of IP6K2 mRNA
CTD
PMID:31324951
NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
G
Irf2bp2
interferon regulatory factor 2 binding protein 2
decreases expression
EXP
Phenformin results in decreased expression of IRF2BP2 mRNA
CTD
PMID:31324951
NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642
G
Irf2bpl
interferon regulatory factor 2 binding protein-like
decreases expression
EXP
Phenformin results in decreased expression of IRF2BPL mRNA
CTD
PMID:31324951
NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401
G
Irs2
insulin receptor substrate 2
decreases expression
EXP
Phenformin results in decreased expression of IRS2 mRNA
CTD
PMID:31324951
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Phenformin results in decreased expression of JUN mRNA
CTD
PMID:31324951
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
Phenformin results in decreased expression of JUNB mRNA
CTD
PMID:31324951
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
G
Kcna2
potassium voltage-gated channel subfamily A member 2
increases expression
EXP
Phenformin results in increased expression of KCNA2 mRNA
CTD
PMID:31324951
NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400
G
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
increases expression
EXP
Phenformin results in increased expression of KCNJ5 mRNA
CTD
PMID:31324951
NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
G
Kif11
kinesin family member 11
decreases expression
EXP
Phenformin results in decreased expression of KIF11 mRNA
CTD
PMID:31324951
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
G
Kif20a
kinesin family member 20A
decreases expression
EXP
Phenformin results in decreased expression of KIF20A mRNA
CTD
PMID:31324951
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
G
Kif20b
kinesin family member 20B
decreases expression
EXP
Phenformin results in decreased expression of KIF20B mRNA
CTD
PMID:31324951
NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
G
Kif23
kinesin family member 23
decreases expression
EXP
Phenformin results in decreased expression of KIF23 mRNA
CTD
PMID:31324951
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
G
Knl1
kinetochore scaffold 1
decreases expression
EXP
Phenformin results in decreased expression of KNL1 mRNA
CTD
PMID:31324951
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
G
Krt18
keratin 18
increases expression
EXP
Phenformin results in increased expression of KRT18 mRNA
CTD
PMID:31324951
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
G
Lbp
lipopolysaccharide binding protein
increases expression
EXP
Phenformin results in increased expression of LBP mRNA
CTD
PMID:31324951
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
G
Lepr
leptin receptor
increases response to substance
EXP
LEPR gene mutant form results in increased susceptibility to Phenformin
CTD
PMID:29743445
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Lgals5
galectin 5
decreases expression
EXP
Phenformin results in decreased expression of LGALS5 mRNA
CTD
PMID:31324951
NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
G
Lgsn
lengsin, lens protein with glutamine synthetase domain
decreases expression
EXP
Phenformin results in decreased expression of LGSN mRNA
CTD
PMID:31324951
NCBI chr 9:33,416,362...33,447,919
Ensembl chr 9:33,420,484...33,447,907
G
Lipo1
lipase, member O1
decreases expression
EXP
Phenformin results in decreased expression of LIPO1 mRNA
CTD
PMID:31324951
NCBI chr 1:231,311,828...231,328,805
Ensembl chr 1:231,311,315...231,325,187
G
Loxl4
lysyl oxidase-like 4
increases expression
EXP
Phenformin results in increased expression of LOXL4 mRNA
CTD
PMID:31324951
NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322
G
Lpar6
lysophosphatidic acid receptor 6
increases expression
EXP
Phenformin results in increased expression of LPAR6 mRNA
CTD
PMID:31324951
NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331
G
Lpin1
lipin 1
decreases expression
EXP
Phenformin results in decreased expression of LPIN1 mRNA
CTD
PMID:31324951
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
G
Lum
lumican
decreases expression
EXP
Phenformin results in decreased expression of LUM mRNA
CTD
PMID:31324951
NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793
G
Lurap1l
leucine rich adaptor protein 1-like
decreases expression
EXP
Phenformin results in decreased expression of LURAP1L mRNA
CTD
PMID:31324951
NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
G
Ly6c
Ly6-C antigen
increases expression
EXP
Phenformin results in increased expression of LY6C mRNA
CTD
PMID:31324951
NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:106,959,511...106,963,329
G
Lynx1
Ly6/neurotoxin 1
decreases expression
EXP
Phenformin results in decreased expression of LYNX1 mRNA
CTD
PMID:31324951
NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
G
Mastl
microtubule associated serine/threonine kinase-like
decreases expression
EXP
Phenformin results in decreased expression of MASTL mRNA
CTD
PMID:31324951
NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
G
Mbnl3
muscleblind-like splicing regulator 3
increases expression
EXP
Phenformin results in increased expression of MBNL3 mRNA
CTD
PMID:31324951
NCBI chr X:130,641,942...130,737,179
Ensembl chr X:130,648,538...130,737,056
G
Mest
mesoderm specific transcript
decreases expression
EXP
Phenformin results in decreased expression of MEST mRNA
CTD
PMID:31324951
NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
G
Mfap4
microfibril associated protein 4
decreases expression
EXP
Phenformin results in decreased expression of MFAP4 mRNA
CTD
PMID:31324951
NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155
G
Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
decreases expression
EXP
Phenformin results in decreased expression of MFSD2A mRNA
CTD
PMID:31324951
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
G
Mgat4b
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
decreases expression
EXP
Phenformin results in decreased expression of MGAT4B mRNA
CTD
PMID:31324951
NCBI chr10:34,548,918...34,559,229
Ensembl chr10:34,549,433...34,559,229
G
Mgp
matrix Gla protein
decreases expression
EXP
Phenformin results in decreased expression of MGP mRNA
CTD
PMID:31324951
NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
G
Mir15b
microRNA 15b
increases expression
EXP
Phenformin results in increased expression of MIR15B mRNA
CTD
PMID:31324951
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
G
Mir29b2
microRNA 29b-2
increases expression
EXP
Phenformin results in increased expression of MIR29B2 mRNA
CTD
PMID:31324951
NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456
G
Mirlet7c1
microRNA let-7c-1
increases expression
EXP
Phenformin results in increased expression of MIRLET7C-1 mRNA
CTD
PMID:31324951
NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
G
Mki67
marker of proliferation Ki-67
decreases expression
EXP
Phenformin results in decreased expression of MKI67 mRNA
CTD
PMID:31324951
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mknk2
MAPK interacting serine/threonine kinase 2
decreases expression
EXP
Phenformin results in decreased expression of MKNK2 mRNA
CTD
PMID:31324951
NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827
G
Mlxipl
MLX interacting protein-like
decreases expression
EXP
Phenformin results in decreased expression of MLXIPL mRNA
CTD
PMID:31324951
NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
G
Mst1r
macrophage stimulating 1 receptor
decreases expression
EXP
Phenformin results in decreased expression of MST1R mRNA
CTD
PMID:31324951
NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455
G
Mt1
metallothionein 1
increases expression
EXP
Phenformin results in increased expression of MT1A mRNA
CTD
PMID:31324951
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
G
Mt1-ps3
metallothionein 1, pseudogene 3
increases expression
EXP
Phenformin results in increased expression of MT1M mRNA
CTD
PMID:31324951
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
G
Mt2A
metallothionein 2A
increases expression
EXP
Phenformin results in increased expression of MT2A mRNA
CTD
PMID:31324951
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mtss1
MTSS I-BAR domain containing 1
decreases expression
EXP
Phenformin results in decreased expression of MTSS1 mRNA
CTD
PMID:31324951
NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
G
Mx2
MX dynamin like GTPase 2
increases expression
EXP
Phenformin results in increased expression of MX2 mRNA
CTD
PMID:31324951
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
EXP
Phenformin results in decreased expression of MYC mRNA
CTD
PMID:31324951
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Myh7
myosin heavy chain 7
increases expression
EXP
Phenformin results in increased expression of MYH7 mRNA
CTD
PMID:31324951
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
G
Myoc
myocilin
increases expression
EXP
Phenformin results in increased expression of MYOC mRNA
CTD
PMID:31324951
NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
G
Myom2
myomesin 2
increases expression
EXP
Phenformin results in increased expression of MYOM2 mRNA
CTD
PMID:31324951
NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
G
Ncapg
non-SMC condensin I complex, subunit G
decreases expression
EXP
Phenformin results in decreased expression of NCAPG mRNA
CTD
PMID:31324951
NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902
G
Ncf1
neutrophil cytosolic factor 1
increases expression
EXP
Phenformin results in increased expression of NCF1 mRNA
CTD
PMID:31324951
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
G
Ndc80
NDC80 kinetochore complex component
decreases expression
EXP
Phenformin results in decreased expression of NDC80 mRNA
CTD
PMID:31324951
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
G
Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
Phenformin results in increased activity of NFE2L2 protein
CTD
PMID:30114225
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
decreases expression
EXP
Phenformin results in decreased expression of NFKBIA mRNA
CTD
PMID:31324951
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Ngef
neuronal guanine nucleotide exchange factor
decreases expression
EXP
Phenformin results in decreased expression of NGEF mRNA
CTD
PMID:31324951
NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
G
Noct
nocturnin
decreases expression
EXP
Phenformin results in decreased expression of NOCT mRNA
CTD
PMID:31324951
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
G
Nppa
natriuretic peptide A
increases expression
EXP
Phenformin results in increased expression of NPPA mRNA
CTD
PMID:31324951
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Npr3
natriuretic peptide receptor 3
increases expression
EXP
Phenformin results in increased expression of NPR3 mRNA
CTD
PMID:31324951
NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
G
Npy
neuropeptide Y
affects expression
EXP
Phenformin affects the expression of NPY mRNA
CTD
PMID:31324951
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
Phenformin results in increased expression of NQO1 mRNA
CTD
PMID:31324951
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
EXP
Phenformin results in increased expression of NR1D1 mRNA
CTD
PMID:31324951
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
G
Nr1d2
nuclear receptor subfamily 1, group D, member 2
increases expression
EXP
Phenformin results in increased expression of NR1D2 mRNA
CTD
PMID:31324951
NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
EXP
Phenformin results in decreased expression of NR4A1 mRNA
CTD
PMID:31324951
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
EXP
Phenformin results in decreased expression of NR4A2 mRNA
CTD
PMID:31324951
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
G
Nr4a3
nuclear receptor subfamily 4, group A, member 3
decreases expression
EXP
Phenformin results in decreased expression of NR4A3 mRNA
CTD
PMID:31324951
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
G
Nuf2
NUF2 component of NDC80 kinetochore complex
decreases expression
EXP
Phenformin results in decreased expression of NUF2 mRNA
CTD
PMID:31324951
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
G
Nusap1
nucleolar and spindle associated protein 1
decreases expression
EXP
Phenformin results in decreased expression of NUSAP1 mRNA
CTD
PMID:31324951
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
G
Oaf
out at first homolog
increases expression
EXP
Phenformin results in increased expression of OAF mRNA
CTD
PMID:31324951
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
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Oat
ornithine aminotransferase
increases expression
EXP
Phenformin results in increased expression of OAT mRNA
CTD
PMID:31324951
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Olr906
olfactory receptor 906
increases expression
EXP
Phenformin results in increased expression of OLR906 mRNA
CTD
PMID:31324951
NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202
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Omd
osteomodulin
decreases expression
EXP
Phenformin results in decreased expression of OMD mRNA
CTD
PMID:31324951
NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
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Opcml
opioid binding protein/cell adhesion molecule-like
decreases expression
EXP
Phenformin results in decreased expression of OPCML mRNA
CTD
PMID:31324951
NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620
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Osbpl3
oxysterol binding protein-like 3
decreases expression
EXP
Phenformin results in decreased expression of OSBPL3 mRNA
CTD
PMID:31324951
NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393
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Osgin1
oxidative stress induced growth inhibitor 1
decreases expression
EXP
Phenformin results in decreased expression of OSGIN1 mRNA
CTD
PMID:31324951
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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Otud1
OTU deubiquitinase 1
decreases expression
EXP
Phenformin results in decreased expression of OTUD1 mRNA
CTD
PMID:31324951
NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995
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P2rx7
purinergic receptor P2X 7
increases expression
EXP
Phenformin results in increased expression of P2RX7 mRNA
CTD
PMID:31324951
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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P2ry2
purinergic receptor P2Y2
increases expression
EXP
Phenformin results in increased expression of P2RY2 mRNA
CTD
PMID:31324951
NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
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Paqr9
progestin and adipoQ receptor family member 9
decreases expression
EXP
Phenformin results in decreased expression of PAQR9 mRNA
CTD
PMID:31324951
NCBI chr 8:96,114,249...96,116,546
G
Pbk
PDZ binding kinase
decreases expression
EXP
Phenformin results in decreased expression of PBK mRNA
CTD
PMID:31324951
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
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Pbld1
phenazine biosynthesis-like protein domain containing 1
increases expression
EXP
Phenformin results in increased expression of PBLD1 mRNA
CTD
PMID:31324951
NCBI chr20:25,551,274...25,566,543
Ensembl chr20:25,551,275...25,565,614
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Pclaf
PCNA clamp associated factor
decreases expression
EXP
Phenformin results in decreased expression of PCLAF mRNA
CTD
PMID:31324951
NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
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Pde4b
phosphodiesterase 4B
increases expression
EXP
Phenformin results in increased expression of PDE4B mRNA
CTD
PMID:31324951
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
EXP
Phenformin results in increased expression of PDK4 mRNA
CTD
PMID:31324951
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Pdlim1
PDZ and LIM domain 1
decreases expression
EXP
Phenformin results in decreased expression of PDLIM1 mRNA
CTD
PMID:31324951
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
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Pdlim3
PDZ and LIM domain 3
decreases expression
EXP
Phenformin results in decreased expression of PDLIM3 mRNA
CTD
PMID:31324951
NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
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Pdzrn3
PDZ domain containing RING finger 3
increases expression
EXP
Phenformin results in increased expression of PDZRN3 mRNA
CTD
PMID:31324951
NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
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Penk
proenkephalin
increases expression
EXP
Phenformin results in increased expression of PENK mRNA
CTD
PMID:31324951
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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Per1
period circadian regulator 1
decreases expression
EXP
Phenformin results in decreased expression of PER1 mRNA
CTD
PMID:31324951
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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Per2
period circadian regulator 2
decreases expression
EXP
Phenformin results in decreased expression of PER2 mRNA
CTD
PMID:31324951
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Pex11a
peroxisomal biogenesis factor 11 alpha
increases expression
EXP
Phenformin results in increased expression of PEX11A mRNA
CTD
PMID:31324951
NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
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Pex16
peroxisomal biogenesis factor 16
increases expression
EXP
Phenformin results in increased expression of PEX16 mRNA
CTD
PMID:31324951
NCBI chr 3:78,347,212...78,352,603
Ensembl chr 3:78,343,164...78,353,207
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Pf4
platelet factor 4
decreases expression
EXP
Phenformin results in decreased expression of PF4 mRNA
CTD
PMID:31324951
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
decreases expression
EXP
Phenformin results in decreased expression of PFKFB1 mRNA
CTD
PMID:31324951
NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182
G
Phtf1
putative homeodomain transcription factor 1
decreases expression
EXP
Phenformin results in decreased expression of PHTF1 mRNA
CTD
PMID:31324951
NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078
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Pi15
peptidase inhibitor 15
decreases expression
EXP
Phenformin results in decreased expression of PI15 mRNA
CTD
PMID:31324951
NCBI chr 5:1,395,094...1,423,213
Ensembl chr 5:1,395,094...1,423,213
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
decreases expression
EXP
Phenformin results in decreased expression of PIK3R1 mRNA
CTD
PMID:31324951
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pklr
pyruvate kinase L/R
decreases expression
EXP
Phenformin results in decreased expression of PKLR mRNA
CTD
PMID:31324951
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Pla2g12a
phospholipase A2, group XIIA
increases expression
EXP
Phenformin results in increased expression of PLA2G12A mRNA
CTD
PMID:31324951
NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
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Plcg1
phospholipase C, gamma 1
increases phosphorylation
ISO
Phenformin results in increased phosphorylation of PLCG1 protein
CTD
PMID:19901985
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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Plin2
perilipin 2
decreases expression
EXP
Phenformin results in decreased expression of PLIN2 mRNA
CTD
PMID:31324951
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Plk1
polo-like kinase 1
decreases expression
EXP
Phenformin results in decreased expression of PLK1 mRNA
CTD
PMID:31324951
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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Plppr1
phospholipid phosphatase related 1
decreases expression
EXP
Phenformin results in decreased expression of PLPPR1 mRNA
CTD
PMID:31324951
NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835
G
Pnpla3
patatin-like phospholipase domain containing 3
decreases expression
EXP
Phenformin results in decreased expression of PNPLA3 mRNA
CTD
PMID:31324951
NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
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Por
cytochrome p450 oxidoreductase
decreases expression
EXP
Phenformin results in decreased expression of POR mRNA
CTD
PMID:31324951
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Potef
POTE ankyrin domain family, member F
decreases expression
EXP
Phenformin results in decreased expression of POTEF mRNA
CTD
PMID:31324951
NCBI chr18:23,626,518...23,629,132
Ensembl chr 3:72,977,767...72,979,694
G
Ppard
peroxisome proliferator-activated receptor delta
decreases expression
EXP
Phenformin results in decreased expression of PPARD mRNA
CTD
PMID:31324951
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Ppcs
phosphopantothenoylcysteine synthetase
increases expression
EXP
Phenformin results in increased expression of PPCS mRNA
CTD
PMID:31324951
NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933
G
Ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
increases expression
EXP
Phenformin results in increased expression of PPM1K mRNA
CTD
PMID:31324951
NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
decreases expression
EXP
Phenformin results in decreased expression of PPP1R15A mRNA
CTD
PMID:31324951
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
G
Ppp1r3b
protein phosphatase 1, regulatory subunit 3B
decreases expression
EXP
Phenformin results in decreased expression of PPP1R3B mRNA
CTD
PMID:31324951
NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
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Prc1
protein regulator of cytokinesis 1
decreases expression
EXP
Phenformin results in decreased expression of PRC1 mRNA
CTD
PMID:31324951
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prim1
DNA primase subunit 1
decreases expression
EXP
Phenformin results in decreased expression of PRIM1 mRNA
CTD
PMID:31324951
NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
increases phosphorylation
ISO
Phenformin results in increased phosphorylation of PRKAA1 protein
CTD
PMID:19901985
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
G
Prox1
prospero homeobox 1
increases expression
EXP
Phenformin results in increased expression of PROX1 mRNA
CTD
PMID:31324951
NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
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Prrg4
proline rich and Gla domain 4
decreases expression
EXP
Phenformin results in decreased expression of PRRG4 mRNA
CTD
PMID:31324951
NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273
G
Psmb8
proteasome 20S subunit beta 8
increases expression
EXP
Phenformin results in increased expression of PSMB8 mRNA
CTD
PMID:31324951
NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
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Ptk6
protein tyrosine kinase 6
decreases expression
EXP
Phenformin results in decreased expression of PTK6 mRNA
CTD
PMID:31324951
NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664
G
Ptpn3
protein tyrosine phosphatase, non-receptor type 3
increases expression
EXP
Phenformin results in increased expression of PTPN3 mRNA
CTD
PMID:31324951
NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
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Pum3-ps3
pumilio RNA-binding family member 3, pseudogene 3
increases expression
EXP
Phenformin results in increased expression of PUM3-PS3 mRNA
CTD
PMID:31324951
NCBI chr12:16,357,131...16,359,221
G
Rab30
RAB30, member RAS oncogene family
increases expression
EXP
Phenformin results in increased expression of RAB30 mRNA
CTD
PMID:31324951
NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181
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Rapgef5
Rap guanine nucleotide exchange factor 5
decreases expression
EXP
Phenformin results in decreased expression of RAPGEF5 mRNA
CTD
PMID:31324951
NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
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Rcan1
regulator of calcineurin 1
decreases expression
EXP
Phenformin results in decreased expression of RCAN1 mRNA
CTD
PMID:31324951
NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
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Rdh5
retinol dehydrogenase 5
decreases expression
EXP
Phenformin results in decreased expression of RDH5 mRNA
CTD
PMID:31324951
NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558
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Reg3g
regenerating family member 3 gamma
increases expression
EXP
Phenformin results in increased expression of REG3G mRNA
CTD
PMID:31324951
NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
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RGD1309362
similar to interferon-inducible GTPase
increases expression
EXP
Phenformin results in increased expression of RGD1309362 mRNA
CTD
PMID:31324951
G
Rgs2
regulator of G-protein signaling 2
decreases expression
EXP
Phenformin results in decreased expression of RGS2 mRNA
CTD
PMID:31324951
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
G
Rp1
RP1, axonemal microtubule associated
decreases expression
EXP
Phenformin results in decreased expression of RP1 mRNA
CTD
PMID:31324951
NCBI chr 5:15,121,104...15,582,363
Ensembl chr 5:15,121,133...15,579,363
G
Rrm2
ribonucleotide reductase regulatory subunit M2
decreases expression
EXP
Phenformin results in decreased expression of RRM2 mRNA
CTD
PMID:31324951
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
G
RT1-A
RT1 class I, locus A
decreases expression
EXP
Phenformin results in decreased expression of RT1-A mRNA
CTD
PMID:31324951
G
Sbk1
SH3 domain binding kinase 1
increases expression
EXP
Phenformin results in increased expression of SBK1 mRNA
CTD
PMID:31324951
NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885
G
Scarna15
small Cajal body-specific RNA 15
decreases expression
EXP
Phenformin results in decreased expression of SCARNA15 mRNA
CTD
PMID:31324951
NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:135,484,559...135,484,685 Ensembl chr 1:135,484,559...135,484,685
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Scd
stearoyl-CoA desaturase
decreases expression
EXP
Phenformin results in decreased expression of SCD1 mRNA
CTD
PMID:31324951
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Sdc4
syndecan 4
decreases expression
EXP
Phenformin results in decreased expression of SDC4 mRNA
CTD
PMID:31324951
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
G
Sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
increases expression
EXP
Phenformin results in increased expression of SDR42E1 mRNA
CTD
PMID:31324951
NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901
G
Sds
serine dehydratase
increases expression
EXP
Phenformin results in increased expression of SDS mRNA
CTD
PMID:31324951
NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
G
Serpina7
serpin family A member 7
increases expression
EXP
Phenformin results in increased expression of SERPINA7 mRNA
CTD
PMID:31324951
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
G
Serpinc1
serpin family C member 1
increases activity
ISO
Phenformin results in increased activity of SERPINC1 protein
CTD
PMID:29458015
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1
serpin family E member 1
decreases expression
EXP
Phenformin results in decreased expression of SERPINE1 mRNA
CTD
PMID:31324951
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Sik1
salt-inducible kinase 1
decreases expression
EXP
Phenformin results in decreased expression of SIK1 mRNA
CTD
PMID:31324951
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Sirt1
sirtuin 1
decreases expression
ISO
Phenformin results in decreased expression of SIRT1 protein
CTD
PMID:26768367
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
G
Slc10a2
solute carrier family 10 member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC10A2 mRNA
CTD
PMID:31324951
NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
G
Slc10a5
solute carrier family 10, member 5
decreases expression
EXP
Phenformin results in decreased expression of SLC10A5 mRNA
CTD
PMID:31324951
NCBI chr 2:91,457,540...91,458,844
Ensembl chr 2:91,444,454...91,489,651
G
Slc13a2
solute carrier family 13 member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC13A2 mRNA
CTD
PMID:31324951
NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127
G
Slc13a3
solute carrier family 13 member 3
increases expression
EXP
Phenformin results in increased expression of SLC13A3 mRNA
CTD
PMID:31324951
NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
G
Slc16a10
solute carrier family 16 member 10
increases expression
EXP
Phenformin results in increased expression of SLC16A10 mRNA
CTD
PMID:31324951
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
G
Slc17a9
solute carrier family 17 member 9
decreases expression
EXP
Phenformin results in decreased expression of SLC17A9 mRNA
CTD
PMID:31324951
NCBI chr 3:167,839,246...167,857,462
Ensembl chr 3:167,839,385...167,855,985
G
Slc19a3
solute carrier family 19 member 3
multiple interactions
ISO
Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
CTD
PMID:26528626
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
G
Slc1a2
solute carrier family 1 member 2
increases expression
EXP
Phenformin results in increased expression of SLC1A2 mRNA
CTD
PMID:31324951
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
G
Slc1a4
solute carrier family 1 member 4
increases expression
EXP
Phenformin results in increased expression of SLC1A4 mRNA
CTD
PMID:31324951
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Phenformin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a23
solute carrier family 22, member 23
decreases expression
EXP
Phenformin results in decreased expression of SLC22A23 mRNA
CTD
PMID:31324951
NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790
G
Slc22a4
solute carrier family 22 member 4
increases response to substance affects uptake
ISO
SLC22A4 protein results in increased susceptibility to Phenformin SLC22A4 protein affects the uptake of Phenformin
CTD
PMID:23221006
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
G
Slc22a5
solute carrier family 22 member 5
increases expression
EXP
Phenformin results in increased expression of SLC22A5 mRNA
CTD
PMID:31324951
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
G
Slc25a23
solute carrier family 25 member 23
decreases expression
EXP
Phenformin results in decreased expression of SLC25A23 mRNA
CTD
PMID:31324951
NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561
G
Slc25a47
solute carrier family 25, member 47
increases expression
EXP
Phenformin results in increased expression of SLC25A47 mRNA
CTD
PMID:31324951
NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
G
Slc27a1
solute carrier family 27 member 1
increases expression
EXP
Phenformin results in increased expression of SLC27A1 mRNA
CTD
PMID:31324951
NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
G
Slc2a12
solute carrier family 2 member 12
increases expression
EXP
Phenformin results in increased expression of SLC2A12 mRNA
CTD
PMID:31324951
NCBI chr 1:22,803,068...22,862,204
Ensembl chr 1:22,804,418...22,860,971
G
Slc2a5
solute carrier family 2 member 5
decreases expression
EXP
Phenformin results in decreased expression of SLC2A5 mRNA
CTD
PMID:31324951
NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
G
Slc34a2
solute carrier family 34 member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC34A2 mRNA
CTD
PMID:31324951
NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
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Slc35c2
solute carrier family 35 member C2
decreases expression
EXP
Phenformin results in decreased expression of SLC35C2 mRNA
CTD
PMID:31324951
NCBI chr 3:154,012,262...154,023,549
Ensembl chr 3:154,012,416...154,023,488
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Slc38a2
solute carrier family 38, member 2
decreases expression
EXP
Phenformin results in decreased expression of SLC38A2 mRNA
CTD
PMID:31324951
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Phenformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Phenformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc4a1
solute carrier family 4 member 1 (Diego blood group)
decreases expression
EXP
Phenformin results in decreased expression of SLC4A1 mRNA
CTD
PMID:31324951
NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
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Slc4a4
solute carrier family 4 member 4
increases expression
EXP
Phenformin results in increased expression of SLC4A4 mRNA
CTD
PMID:31324951
NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
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Slc6a6
solute carrier family 6 member 6
increases expression
EXP
Phenformin results in increased expression of SLC6A6 mRNA
CTD
PMID:31324951
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
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Smco1
single-pass membrane protein with coiled-coil domains 1
increases expression
EXP
Phenformin results in increased expression of SMCO1 mRNA
CTD
PMID:31324951
NCBI chr11:68,512,113...68,514,999
Ensembl chr11:68,509,150...68,515,003
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Snai2
snail family transcriptional repressor 2
increases expression
EXP
Phenformin results in increased expression of SNAI2 mRNA
CTD
PMID:31324951
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Sntb1
syntrophin, beta 1
increases expression
EXP
Phenformin results in increased expression of SNTB1 mRNA
CTD
PMID:31324951
NCBI chr 7:87,060,926...87,329,315
Ensembl chr 7:87,060,926...87,329,315
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Socs2
suppressor of cytokine signaling 2
decreases expression
EXP
Phenformin results in decreased expression of SOCS2 mRNA
CTD
PMID:31324951
NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
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Spink1
serine peptidase inhibitor, Kazal type 1
increases expression
EXP
Phenformin results in increased expression of SPINK1 mRNA
CTD
PMID:31324951
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
Phenformin results in decreased expression of SREBF1 mRNA
CTD
PMID:31324951
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Stac3
SH3 and cysteine rich domain 3
decreases expression
EXP
Phenformin results in decreased expression of STAC3 mRNA
CTD
PMID:31324951
NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
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Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Phenformin results in increased expression of STAT3 mRNA
CTD
PMID:31324951
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
Phenformin results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Stmn1
stathmin 1
decreases expression
EXP
Phenformin results in decreased expression of STMN1 mRNA
CTD
PMID:31324951
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Stxbp6
syntaxin binding protein 6
increases expression
EXP
Phenformin results in increased expression of STXBP6 mRNA
CTD
PMID:31324951
NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
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Tbx3
T-box transcription factor 3
increases expression
EXP
Phenformin results in increased expression of TBX3 mRNA
CTD
PMID:31324951
NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
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Tcap
titin-cap
increases expression
EXP
Phenformin results in increased expression of TCAP mRNA
CTD
PMID:31324951
NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887
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Tex36
testis expressed 36
increases expression
EXP
Phenformin results in increased expression of TEX36 mRNA
CTD
PMID:31324951
NCBI chr 1:188,390,062...188,404,448
Ensembl chr 1:188,390,064...188,404,377
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Thbs1
thrombospondin 1
increases expression
EXP
Phenformin results in increased expression of THBS1 mRNA
CTD
PMID:31324951
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Thrsp
thyroid hormone responsive
decreases expression
EXP
Phenformin results in decreased expression of THRSP mRNA
CTD
PMID:31324951
NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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Tk1
thymidine kinase 1
decreases expression
EXP
Phenformin results in decreased expression of TK1 mRNA
CTD
PMID:31324951
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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Tkfc
triokinase and FMN cyclase
decreases expression
EXP
Phenformin results in decreased expression of TKFC mRNA
CTD
PMID:31324951
NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
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Tm7sf2
transmembrane 7 superfamily member 2
increases expression
EXP
Phenformin results in increased expression of TM7SF2 mRNA
CTD
PMID:31324951
NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
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Tmem30b
transmembrane protein 30B
increases expression
EXP
Phenformin results in increased expression of TMEM30B mRNA
CTD
PMID:31324951
NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842
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Tmem37
transmembrane protein 37
decreases expression
EXP
Phenformin results in decreased expression of TMEM37 mRNA
CTD
PMID:31324951
NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077
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Tmod4
tropomodulin 4
increases expression
EXP
Phenformin results in increased expression of TMOD4 mRNA
CTD
PMID:31324951
NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540
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Tnfaip2
TNF alpha induced protein 2
increases expression
EXP
Phenformin results in increased expression of TNFAIP2 mRNA
CTD
PMID:31324951
NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
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Tnfaip3
TNF alpha induced protein 3
decreases expression
EXP
Phenformin results in decreased expression of TNFAIP3 mRNA
CTD
PMID:31324951
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tnfsf13
TNF superfamily member 13
decreases expression
EXP
Phenformin results in decreased expression of TNFSF13 mRNA
CTD
PMID:31324951
NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
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Tob2
transducer of ERBB2, 2
decreases expression
EXP
Phenformin results in decreased expression of TOB2 mRNA
CTD
PMID:31324951
NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688
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Top2a
DNA topoisomerase II alpha
decreases expression
EXP
Phenformin results in decreased expression of TOP2A mRNA
CTD
PMID:31324951
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
decreases expression
EXP
Phenformin results in decreased expression of TP53INP1 mRNA
CTD
PMID:31324951
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Tppp
tubulin polymerization promoting protein
decreases expression
EXP
Phenformin results in decreased expression of TPPP mRNA
CTD
PMID:31324951
NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134
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Tpx2
TPX2, microtubule nucleation factor
decreases expression
EXP
Phenformin results in decreased expression of TPX2 mRNA
CTD
PMID:31324951
NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
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Trim24
tripartite motif-containing 24
increases expression
EXP
Phenformin results in increased expression of TRIM24 mRNA
CTD
PMID:31324951
NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241
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Trim50
tripartite motif-containing 50
increases expression
EXP
Phenformin results in increased expression of TRIM50 mRNA
CTD
PMID:31324951
NCBI chr12:21,300,784...21,317,668
Ensembl chr12:21,300,785...21,317,668
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Tsc22d3
TSC22 domain family, member 3
decreases expression
EXP
Phenformin results in decreased expression of TSC22D3 mRNA
CTD
PMID:31324951
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
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Tsku
tsukushi, small leucine rich proteoglycan
decreases expression
EXP
Phenformin results in decreased expression of TSKU mRNA
CTD
PMID:31324951
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
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Tspan4
tetraspanin 4
decreases expression
EXP
Phenformin results in decreased expression of TSPAN4 mRNA
CTD
PMID:31324951
NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448
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Ttk
Ttk protein kinase
decreases expression
EXP
Phenformin results in decreased expression of TTK mRNA
CTD
PMID:31324951
NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
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Tubb1
tubulin, beta 1 class VI
decreases expression
EXP
Phenformin results in decreased expression of TUBB1 mRNA
CTD
PMID:31324951
NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063
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Tubb2a
tubulin, beta 2A class IIa
decreases expression
EXP
Phenformin results in decreased expression of TUBB2A mRNA
CTD
PMID:31324951
NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
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Txnip
thioredoxin interacting protein
increases expression
EXP
Phenformin results in increased expression of TXNIP mRNA
CTD
PMID:31324951
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Ube2c
ubiquitin-conjugating enzyme E2C
decreases expression
EXP
Phenformin results in decreased expression of UBE2C mRNA
CTD
PMID:31324951
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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Ucp3
uncoupling protein 3
increases expression
EXP
Phenformin results in increased expression of UCP3 mRNA
CTD
PMID:31324951
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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Ugdh
UDP-glucose 6-dehydrogenase
decreases expression
EXP
Phenformin results in decreased expression of UGDH protein
CTD
PMID:4270849
NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
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Ugt2a3
UDP glucuronosyltransferase family 2 member A3
increases expression
EXP
Phenformin results in increased expression of UGT2A3 mRNA
CTD
PMID:31324951
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Phenformin results in increased expression of UGT2B1 mRNA
CTD
PMID:31324951
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
increases expression
EXP
Phenformin results in increased expression of UGT2B34L1 mRNA
CTD
PMID:31324951
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
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Upp2
uridine phosphorylase 2
increases expression
EXP
Phenformin results in increased expression of UPP2 mRNA
CTD
PMID:31324951
NCBI chr 3:43,273,048...43,317,417
Ensembl chr 3:43,273,048...43,317,417
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Usp18
ubiquitin specific peptidase 18
increases expression
EXP
Phenformin results in increased expression of USP18 mRNA
CTD
PMID:31324951
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
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Usp2
ubiquitin specific peptidase 2
decreases expression
EXP
Phenformin results in decreased expression of USP2 mRNA
CTD
PMID:31324951
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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Vgll4
vestigial-like family member 4
decreases expression
EXP
Phenformin results in decreased expression of VGLL4 mRNA
CTD
PMID:31324951
NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471
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Vnn1
vanin 1
increases expression
EXP
Phenformin results in increased expression of VNN1 mRNA
CTD
PMID:31324951
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
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Wee1
WEE1 G2 checkpoint kinase
decreases expression
EXP
Phenformin results in decreased expression of WEE1 mRNA
CTD
PMID:31324951
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
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Xiap
X-linked inhibitor of apoptosis
increases expression
EXP
Phenformin results in increased expression of XIAP mRNA
CTD
PMID:31324951
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Ypel2
yippee-like 2
decreases expression
EXP
Phenformin results in decreased expression of YPEL2 mRNA
CTD
PMID:31324951
NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911
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Zbtb16
zinc finger and BTB domain containing 16
decreases expression
EXP
Phenformin results in decreased expression of ZBTB16 mRNA
CTD
PMID:31324951
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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Zfp354a
zinc finger protein 354A
decreases expression
EXP
Phenformin results in decreased expression of ZFP354A mRNA
CTD
PMID:31324951
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
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Zfp36
zinc finger protein 36
decreases expression
EXP
Phenformin results in decreased expression of ZFP36 mRNA
CTD
PMID:31324951
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Znf750
zinc finger protein 750
increases expression
EXP
Phenformin results in increased expression of ZNF750 mRNA
CTD
PMID:31324951
NCBI chr10:106,772,162...106,781,186
Ensembl chr10:106,772,669...106,781,200
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