Fgf6 (fibroblast growth factor 6) - Rat Genome Database

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Gene: Fgf6 (fibroblast growth factor 6) Rattus norvegicus
Analyze
Symbol: Fgf6
Name: fibroblast growth factor 6
RGD ID: 620130
Description: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to act upstream of or within cartilage condensation and myoblast differentiation. Located in sarcolemma. Orthologous to human FGF6 (fibroblast growth factor 6); PARTICIPATES IN fibroblast growth factor signaling pathway; syndecan signaling pathway; melanoma pathway; INTERACTS WITH ammonium chloride; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fgf7b; fibroblast growth factor 7b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,541,089 - 161,549,624 (+)NCBIGRCr8
mRatBN7.24159,854,913 - 159,863,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,854,913 - 159,863,447 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,084,732 - 166,093,267 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,867,644 - 161,876,179 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,501,682 - 160,510,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,563,798 - 159,572,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,563,798 - 159,572,333 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,040,999 - 232,049,534 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,403,896 - 163,412,431 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,648,831 - 163,657,367 (+)NCBI
Celera4148,570,431 - 148,578,966 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6RatAcute Otitis Media  ISOFgf6 (Mus musculus)127284853mRNA:decreased expression:middle ear (mouse)RGD 
Fgf6Ratprostate carcinoma in situ  ISOFGF6 (Homo sapiens)2301089protein:increased expression:prostate glandRGD 
Fgf6RatProstatic Neoplasms  ISOFGF6 (Homo sapiens)2289066 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratepisodic ataxia type 1  ISOFGF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Episodic ataxia type 1ClinVarPMID:28492532
Fgf6RatHyperphosphatemic Familial Tumoral Calcinosis 1  ISOFGF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Tumoral calcinosis more ...ClinVarPMID:25378588 and PMID:29389098
Fgf6Ratlymphoproliferative syndrome 2  ISOFGF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphoproliferative syndrome 2ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratamyotrophic lateral sclerosis type 1  ISOFGF6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11796754

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Rat(S)-amphetamine increases expressionISOFgf6 (Mus musculus)6480464Dextroamphetamine results in increased expression of FGF6 mRNACTDPMID:12205029
Fgf6Rat(S)-amphetamine multiple interactionsISOFgf6 (Mus musculus)6480464SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FGF6 mRNA]CTDPMID:12205029
Fgf6Rat17alpha-ethynylestradiol multiple interactionsISOFgf6 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGF6 mRNACTDPMID:17942748
Fgf6Rat17alpha-ethynylestradiol increases expressionISOFgf6 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of FGF6 mRNACTDPMID:17942748
Fgf6Rat17beta-estradiol increases expressionISOFGF6 (Homo sapiens)6480464Estradiol results in increased expression of FGF6 mRNACTDPMID:21098263
Fgf6Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOFgf6 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Fgf6Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOFgf6 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Fgf6Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFgf6 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FGF6 mRNACTDPMID:17942748
Fgf6Ratadenosine multiple interactionsISOFGF6 (Homo sapiens)6480464Adenosine results in increased expression of and results in increased secretion of FGF6 proteinCTDPMID:34070360
Fgf6Rataflatoxin B1 decreases methylationISOFGF6 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of FGF6 geneCTDPMID:27153756
Fgf6Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of FGF6 mRNACTDPMID:16483693
Fgf6Ratarsane affects expressionISOFGF6 (Homo sapiens)6480464Arsenic affects the expression of FGF6 proteinCTDPMID:24675094
Fgf6Ratarsenic atom affects expressionISOFGF6 (Homo sapiens)6480464Arsenic affects the expression of FGF6 proteinCTDPMID:24675094
Fgf6Ratarsenous acid increases expressionISOFgf6 (Mus musculus)6480464Arsenic Trioxide results in increased expression of FGF6 mRNACTDPMID:35676786
Fgf6Ratatrazine increases expressionISOFGF6 (Homo sapiens)6480464Atrazine results in increased expression of FGF6 mRNACTDPMID:22378314
Fgf6Ratbenzo[a]pyrene increases methylationISOFGF6 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of FGF6 promoterCTDPMID:27901495
Fgf6Ratbenzo[a]pyrene affects methylationISOFGF6 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of FGF6 exonCTDPMID:27901495
Fgf6Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of FGF6 mRNACTDPMID:25181051
Fgf6Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of FGF6 geneCTDPMID:28505145
Fgf6Ratcadmium atom increases expressionISOFGF6 (Homo sapiens)6480464Cadmium results in increased expression of FGF6 mRNACTDPMID:21694771

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Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratbiological_process  ND 159840701/2008: no relevant rat dataRGD 
Fgf6Ratcartilage condensation acts_upstream_of_or_withinIEAUniProtKB:P21658 and ensembl:ENSMUSP000000001871600115GO_REF:0000107EnsemblGO_REF:0000107
Fgf6Ratcartilage condensation acts_upstream_of_or_withinISOFgf6 (Mus musculus)1624291MGI:98726 PMID:8565825RGDPMID:8565825
Fgf6Ratfibroblast growth factor receptor signaling pathway acts_upstream_of_or_withinISOFGF6 (Homo sapiens)1624291UniProtKB:P11362 more ...RGDPMID:8663044
Fgf6Ratfibroblast growth factor receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P10767 and ensembl:ENSP000002288371600115GO_REF:0000107EnsemblGO_REF:0000107
Fgf6Ratfibroblast growth factor receptor signaling pathway involved_inIBAFB:FBgn0014135 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratmyoblast differentiation acts_upstream_of_or_withinISOFgf6 (Mus musculus)1624291 PMID:8223280RGDPMID:8223280
Fgf6Ratmyoblast differentiation acts_upstream_of_or_withinIEAUniProtKB:P21658 and ensembl:ENSMUSP000000001871600115GO_REF:0000107EnsemblGO_REF:0000107
Fgf6Ratneurogenesis involved_inIBAFB:FBgn0014135 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratpositive regulation of cell population proliferation acts_upstream_of_or_withinISOFGF6 (Homo sapiens)1624291UniProtKB:P11362 more ...RGDPMID:8663044
Fgf6Ratpositive regulation of cell population proliferation acts_upstream_of_or_withinIEAUniProtKB:P10767 and ensembl:ENSP000002288371600115GO_REF:0000107EnsemblGO_REF:0000107
Fgf6Ratpositive regulation of cell population proliferation involved_inIBAFB:FBgn0014135 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratpositive regulation of MAPK cascade involved_inIBAMGI:1099809 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratregulation of cell migration involved_inIBAMGI:1099809 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratcytoplasm is_active_inIBAMGI:109178 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratextracellular space is_active_inIBAMGI:1099809 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratsarcolemma  IDA 2289076in fast-twitch oxidative glycolytic FOG fibers of the tibialis anterior muscleRGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratfibroblast growth factor receptor binding enablesIBAFB:FBgn0014135 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratgrowth factor activity enablesIEAInterPro:IPR0022091600115GO_REF:0000002InterProGO_REF:0000002
Fgf6Ratgrowth factor activity enablesIBAMGI:95516 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fgf6Ratprotein binding enablesISOFGF6 (Homo sapiens)1624291UniProtKB:P61601 and PMID:32296183RGDPMID:32296183

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
Fgf6Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fgf6Ratfibroblast growth factor signaling pathway  ISOFGF6 (Homo sapiens)6484113 PIDPID:200220
Fgf6Ratsyndecan signaling pathway  ISOFGF6 (Homo sapiens)6484113 PIDPID:200134

1 to 14 of 14 rows
#
Reference Title
Reference Citation
1. Solvent use and psychiatric comorbidity. Dinwiddie SH, etal., Br J Addict. 1990 Dec;85(12):1647-56.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene expression patterns of the fibroblast growth factors and their receptors during myogenesis of rat satellite cells. Kastner S, etal., J Histochem Cytochem 2000 Aug;48(8):1079-96.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. Ropiquet F, etal., Cancer Res. 2000 Aug 1;60(15):4245-50.
13. Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat muscles. Sakuma K, etal., Biochim Biophys Acta. 2000 Jun 2;1497(1):77-88.
14. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
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PMID:8223280   PMID:8565825   PMID:8663044   PMID:32105707  



Fgf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,541,089 - 161,549,624 (+)NCBIGRCr8
mRatBN7.24159,854,913 - 159,863,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,854,913 - 159,863,447 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,084,732 - 166,093,267 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,867,644 - 161,876,179 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,501,682 - 160,510,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,563,798 - 159,572,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,563,798 - 159,572,333 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,040,999 - 232,049,534 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,403,896 - 163,412,431 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,648,831 - 163,657,367 (+)NCBI
Celera4148,570,431 - 148,578,966 (+)NCBICelera
Cytogenetic Map4q42NCBI
FGF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,434,142 - 4,445,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,428,155 - 4,445,815 (-)EnsemblGRCh38hg38GRCh38
GRCh37124,543,308 - 4,554,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,413,569 - 4,425,041 (-)NCBINCBI36Build 36hg18NCBI36
Build 34124,413,568 - 4,425,041NCBI
Celera126,165,354 - 6,176,826 (-)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,399,989 - 4,411,463 (-)NCBIHuRef
CHM1_1124,542,938 - 4,554,384 (-)NCBICHM1_1
T2T-CHM13v2.0124,440,927 - 4,452,599 (-)NCBIT2T-CHM13v2.0
Fgf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,992,505 - 127,001,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,992,549 - 127,005,150 (+)EnsemblGRCm39 Ensembl
GRCm386127,015,542 - 127,024,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,015,586 - 127,028,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv376126,965,560 - 126,974,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,981,205 - 126,993,806 (+)NCBIMGSCv36mm8
Celera6128,694,407 - 128,703,583 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
Fgf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,246,965 - 2,257,883 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,246,965 - 2,257,883 (-)NCBIChiLan1.0ChiLan1.0
FGF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,973,565 - 9,986,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,971,511 - 9,983,357 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,543,776 - 4,555,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,466,975 - 4,478,459 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,466,975 - 4,478,459 (-)Ensemblpanpan1.1panPan2
FGF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,440,298 - 40,456,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,440,377 - 40,455,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,224,956 - 6,241,616 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,795,894 - 40,812,531 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,795,777 - 40,808,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,684,960 - 40,701,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,709,936 - 40,726,576 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,635,648 - 5,652,137 (-)NCBIUU_Cfam_GSD_1.0
Fgf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,559,308 - 104,575,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,613,048 - 4,624,587 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,613,052 - 4,624,587 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,975,838 - 65,990,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,975,807 - 65,990,035 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,197,796 - 68,207,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,464,159 - 4,476,592 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,464,171 - 4,473,916 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,768,764 - 3,779,212 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,539,989 - 1,551,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,539,964 - 1,551,363 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fgf6
51 total Variants

1 to 10 of 84 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_006185.4(NUMA1):c.1781C>T (p.Ala594Val) single nucleotide variant not specified [RCV004301373] Chr11:72015722 [GRCh38]
Chr11:71726768 [GRCh37]
Chr11:11q13.4
uncertain significance
NM_006185.4(NUMA1):c.1891C>T (p.Arg631Trp) single nucleotide variant not specified [RCV004282341] Chr11:72015612 [GRCh38]
Chr11:71726658 [GRCh37]
Chr11:11q13.4
uncertain significance
NM_006185.4(NUMA1):c.1328G>A (p.Arg443Gln) single nucleotide variant NUMA1-related disorder [RCV003940472]|not provided [RCV000883336] Chr11:72016175 [GRCh38]
Chr11:71727221 [GRCh37]
Chr11:11q13.4
benign
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5
pathogenic
NM_006185.4(NUMA1):c.3152C>T (p.Ala1051Val) single nucleotide variant not provided [RCV000887998] Chr11:72014351 [GRCh38]
Chr11:71725397 [GRCh37]
Chr11:11q13.4
benign
GRCh38/hg38 11q13.4(chr11:71164008-72309374)x3 copy number gain See cases [RCV000051910] Chr11:71164008..72309374 [GRCh38]
Chr11:71088949..72020418 [GRCh37]
Chr11:70552702..71698066 [NCBI36]
Chr11:11q13.4
uncertain significance
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
NM_006185.4(NUMA1):c.1430A>G (p.Asn477Ser) single nucleotide variant NUMA1-related disorder [RCV003930591]|not provided [RCV000883226] Chr11:72016073 [GRCh38]
Chr11:71727119 [GRCh37]
Chr11:11q13.4
benign|likely benign
NM_006185.4(NUMA1):c.725A>G (p.Lys242Arg) single nucleotide variant not provided [RCV000883337] Chr11:72018840 [GRCh38]
Chr11:71729886 [GRCh37]
Chr11:11q13.4
benign
NM_006185.4(NUMA1):c.2306C>T (p.Ala769Val) single nucleotide variant not specified [RCV004319218] Chr11:72015197 [GRCh38]
Chr11:71726243 [GRCh37]
Chr11:11q13.4
uncertain significance
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Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:111
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000026866
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat

1 to 10 of 35 rows
Fgf6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,854,977 - 159,855,146 (+)MAPPERmRatBN7.2
Rnor_6.04159,563,863 - 159,564,031NCBIRnor6.0
Rnor_5.04232,049,301 - 232,049,469UniSTSRnor5.0
RGSC_v3.44163,403,961 - 163,404,129UniSTSRGSC3.4
Celera4148,570,496 - 148,570,664UniSTS
Cytogenetic Map4q42UniSTS
GDB:214840  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,854,748 - 159,855,016 (+)MAPPERmRatBN7.2
Rnor_6.04159,563,634 - 159,563,901NCBIRnor6.0
Rnor_5.04232,049,431 - 232,049,698UniSTSRnor5.0
RGSC_v3.44163,403,732 - 163,403,999UniSTSRGSC3.4
Celera4148,570,267 - 148,570,534UniSTS
Cytogenetic Map4q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 11 21 9 16 17 9 9 5 57 30 4 9 18 8



Ensembl Acc Id: ENSRNOT00000081426   ⟹   ENSRNOP00000068734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4159,854,913 - 159,863,447 (+)Ensembl
Rnor_6.0 Ensembl4159,563,798 - 159,572,333 (+)Ensembl
RefSeq Acc Id: NM_131908   ⟹   NP_571983
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,541,089 - 161,549,624 (+)NCBI
mRatBN7.24159,854,913 - 159,863,447 (+)NCBI
Rnor_6.04159,563,798 - 159,572,333 (+)NCBI
Rnor_5.04232,040,999 - 232,049,534 (-)NCBI
RGSC_v3.44163,403,896 - 163,412,431 (+)RGD
Celera4148,570,431 - 148,578,966 (+)RGD
Sequence:
Protein RefSeqs NP_571983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB84704 (Get FASTA)   NCBI Sequence Viewer  
  EDM01819 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068734.1
  ENSRNOP00000107179
GenBank Protein VDK10965 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_571983   ⟸   NM_131908
- UniProtKB: Q8R5L5 (UniProtKB/TrEMBL),   A6ILX0 (UniProtKB/TrEMBL),   A0A0G2JTJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068734   ⟸   ENSRNOT00000081426

Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5L5-F1-model_v2 AlphaFold Q8R5L5 1-208 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42953 BioCyc
Ensembl Genes ENSRNOG00000053662 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000084144 ENTREZGENE
Ensembl Transcript ENSRNOT00000081426.2 UniProtKB/TrEMBL
  ENSRNOT00000163648 ENTREZGENE
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  GF_heparin_bd UniProtKB/TrEMBL
KEGG Report rno:170700 UniProtKB/TrEMBL
NCBI Gene 170700 ENTREZGENE
PANTHER IL1_HBGF UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PhenoGen Fgf6 PhenoGen
PRINTS HBGFFGF UniProtKB/TrEMBL
  IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053662 RatGTEx
  ENSRNOG00000084144 RatGTEx
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt A0A0G2JTJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6ILX0 ENTREZGENE
  Q8R5L5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6ILX0 UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fgf6  fibroblast growth factor 6      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgf6  fibroblast growth factor 6      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression enriched in in the myofibers, but not in the connective tissue cells surrounding the myofibers or in satellite cells; expressed in skeletal musle tissue 708329