RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: liver cirrhosis
Accession: DOID:5082
browse the term
Definition: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Synonyms: exact_synonym: Hepatic Cirrhosis; Hepatic Fibrosis; cirrhosis; cirrhosis of liver; hepatic cirrhoses; liver cirrhoses; liver fibroses; liver fibrosis
primary_id: MESH:D008103
xref: EFO:0001422 ; ICD10CM:K74.60 ; NCI:C2951
For additional species annotation, visit the
Alliance of Genome Resources .
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A2M
alpha-2-macroglobulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,440,810...62,483,678
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ABCB11
ATP binding cassette subfamily B member 11
severity
ISO
associated with Hepatitis C, Chronic;DNA:SNP:cds:1331T>C, p.V444A,(rs2287622)(human)
RGD
PMID:29755014
RGD:14402415
NCBI chr15:75,402,296...75,487,092
Ensembl chr15:75,402,396...75,486,403
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ABCB4
ATP binding cassette subfamily B member 4
severity susceptibility
ISO
associated with cholestasis;DNA:mutations: : associated with cystic fibrosis;DNA:SNP:exon:c.504T>C(human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8698195 PMID:18221819 PMID:18482588 PMID:19467940
RGD:14694975 RGD:4889446
NCBI chr 9:93,171,371...93,262,124
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ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
treatment severity no_association
ISO
associated with Chronic Hepatitis B;protein:increased expression:blood serum (human) associated with hepatitis C;DNA:insertion/deletion: associated with liver disease;DNA:insertion/deletion:
RGD
PMID:19456900 PMID:26681055 PMID:28822808 PMID:29085215 PMID:29335866
RGD:11537135 RGD:25671453 RGD:25671454 RGD:39939123 RGD:40400898
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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ACTA2
actin alpha 2, smooth muscle
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24239723 PMID:24321339 PMID:30097701 PMID:32659284
NCBI chr14:100,868,145...100,886,732
Ensembl chr14:100,867,733...100,886,713
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ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
severity
ISO
protein:increased expression, increased activity:liver (rat)
RGD
PMID:16689760
RGD:1598737
NCBI chr 1:273,022,014...273,066,916
Ensembl chr 1:273,024,009...273,056,039
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ADAR
adenosine deaminase RNA specific
ameliorates
ISO
associated with human immunodeficiency virus infectious disease, hepatitis C;DNA:SNPs:exon 2, 3' utr:multiple (human)
RGD
PMID:29018269
RGD:125097516
NCBI chr 4:95,154,230...95,197,308
Ensembl chr 4:95,154,357...95,197,304
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ADIPOQ
adiponectin, C1Q and collagen domain containing
severity
ISO
protein:increased expression:plasma
RGD
PMID:16115302
RGD:5686674
NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
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ADIPOR2
adiponectin receptor 2
ISO
mRNA:decreased expression:liver (mouse)
RGD
PMID:17006986
RGD:1599139
NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
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ADRA1A
adrenoceptor alpha 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16782692
NCBI chr14:10,623,391...10,733,378
Ensembl chr14:10,626,293...10,733,068
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AGER
advanced glycosylation end-product specific receptor
ISO
mRNA:decreased expression:lung (liver)
RGD
PMID:22669512
RGD:7245533
NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162
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AGT
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15613622 PMID:21873937
RGD:8549465
NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
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AHR
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29416063
NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
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AKAP12
A-kinase anchoring protein 12
ISO
mRNA,protein:increased expression:liver
RGD
PMID:23925424
RGD:14348971
NCBI chr 1:14,904,109...15,017,016
Ensembl chr 1:14,904,116...15,016,997
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ALAD
aminolevulinate dehydratase
ISO
protein:decreased activity:liver (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:6848403 PMID:25226513
RGD:15042852
NCBI chr 1:254,015,426...254,027,584
Ensembl chr 1:254,011,833...254,027,537
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ALB
albumin
disease_progression
ISO
associated with Head and Neck Neoplasms; CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17977396 PMID:21851314 PMID:23285146
RGD:11035282
NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
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ANKS6
ankyrin repeat and sterile alpha motif domain containing 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23793029
NCBI chr 1:240,522,835...240,584,354
Ensembl chr 1:240,522,837...240,584,496
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APOA1
apolipoprotein A1
ISO
protein:decreased expression:serum (human)
RGD
PMID:27106140
RGD:25671439
NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
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ARNT
aryl hydrocarbon receptor nuclear translocator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22271822
NCBI chr 4:98,333,431...98,390,012
Ensembl chr 4:98,333,459...98,389,457
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ARRB1
arrestin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,516,947...9,597,976
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ARRB2
arrestin beta 2
ISO
protein:increased expression:hepatic artery
RGD
PMID:17256744
RGD:1625784
NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342
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ATG5
autophagy related 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33549628
NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396
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ATM
ATM serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36526012
NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552
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ATP7B
ATPase copper transporting beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25134866
NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064
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AXIN1
axin 1
ISO
protein:decreased expression:liver (human)
RGD
PMID:31514071
RGD:150530482
NCBI chr 3:41,344,908...41,393,999
Ensembl chr 3:41,337,071...41,393,997
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AZGP1
alpha-2-glycoprotein 1, zinc-binding
ISO
associated with hepatocellular carcinoma;protein:decreased expression:liver: associated with hepatitis B;mRNA:decreased expression:liver
RGD
PMID:22625427 PMID:26902423
RGD:153350130 RGD:153350133
NCBI chr 3:7,867,521...7,874,857
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AZIN1
antizyme inhibitor 1
ISO
associated with hepatocellular carcinoma;RNA:increased editing:liver associated with hepatitis B;DNA SNP: :rs2679757 (human)
RGD
PMID:21586232 PMID:23291631
RGD:14700702 RGD:14700705
NCBI chr 4:34,221,368...34,257,261
Ensembl chr 4:34,234,679...34,257,134
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BAMBI
BMP and activin membrane bound inhibitor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30097701
NCBI chr10:40,053,368...40,058,590
Ensembl chr10:40,053,355...40,060,319
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BECN1
beclin 1
ISO
protein:increased expression:skeletal muscle
RGD
PMID:22895779
RGD:11561934
NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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C1QB
complement C1q B chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 6:80,601,680...80,606,076
Ensembl chr 6:80,601,665...80,607,471
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C5
complement C5
disease_progression
ISO
associated with Hepatitis C, Chronic;DNA:SNPs: :rs17611, rs2300929 (human)
RGD
PMID:15995705
RGD:1600592
NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483
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CASP3
caspase 3
ISO
associated with cholestasis
RGD
PMID:29105510
RGD:13782297
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CASP8
caspase 8
ISO
associated with cholestasis
RGD
PMID:29105510
RGD:13782297
NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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CASP9
caspase 9
ISO
associated with cholestasis
RGD
PMID:29105510
RGD:13782297
NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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CCL2
chemokine (C-C motif) ligand 2
ISO
CTD Direct Evidence: marker/mechanism associated with chronic intermittent hypoxia; mRNA, protein:increased expression:liver (rat)
CTD RGD
PMID:20697377 PMID:32626927
RGD:401959337
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
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CCL5
C-C motif chemokine ligand 5
severity treatment
ISO
DNA:SNAP, haplotype: :rs11652536(human)
RGD
PMID:20978355 PMID:28011329
RGD:14995306 RGD:14995328
NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
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CCN2
cellular communication network factor 2
ameliorates
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16652398 PMID:17657819 PMID:26396155 PMID:26946098 PMID:36469291
RGD:243048439 RGD:40925947
NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691
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CCND2
cyclin D2
ISO
associated with hepatitis B;mRNA:decreased expression:Peripheral Blood Mononuclear Cell
RGD
PMID:33320844
RGD:151664743
NCBI chr 5:66,092,483...66,114,575
Ensembl chr 5:66,087,379...66,114,571
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CCR1
C-C motif chemokine receptor 1
ISO
associated with Fatty Liver
RGD
PMID:19280268
RGD:5688143
NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960
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CD14
CD14 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20353583
NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581
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CD163
CD163 molecule
exacerbates
ISO
associated with Chronic Hepatitis B, Chronic Hepatitis C;protein:increased expression:blood plasma (human) protein:increased expression:blood serum (human)
RGD
PMID:24623375 PMID:26339412
RGD:11251207 RGD:127285681
NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498
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CD36
CD36 molecule
ISO
associated with Hypertension, Portal
RGD
PMID:22648712
RGD:6893541
NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105
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CD9
CD9 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 5:64,420,177...64,459,783
Ensembl chr 5:64,420,182...64,460,304
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CDH1
cadherin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32659284
NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986
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CENPC
centromere protein C
ISO
associated with Anticentromere antibody positivity
RGD
PMID:25220385
RGD:27372886
NCBI chr 8:65,237,825...65,315,788
Ensembl chr 8:65,238,090...65,315,713
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CHRM3
cholinergic receptor muscarinic 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20197374
NCBI chr14:51,818,625...52,363,662
Ensembl chr14:51,828,231...51,830,003
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CLDN1
claudin 1
severity
ISO
associated with hepatitis C, Chronic;mRNA,protein:increased expression:liver (human)
RGD
PMID:21620107
RGD:26884347
NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
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CNR1
cannabinoid receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11433348 PMID:21863215
NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602
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CNR2
cannabinoid receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15765409
NCBI chr 6:81,659,162...81,692,550
Ensembl chr 6:81,659,169...81,692,550
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COL1A1
collagen type I alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21863215 PMID:24239723 PMID:24321339 PMID:26396155 PMID:32659284
NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,004
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COL1A2
collagen type I alpha 2 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 9:74,174,484...74,210,407
Ensembl chr 9:74,173,931...74,210,397
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COL3A1
collagen type III alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1880254 PMID:2566230 PMID:11167689 PMID:15787813 PMID:16679477
NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,526,603...93,596,363
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COL5A2
collagen type V alpha 2 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr15:93,611,856...93,981,131
Ensembl chr15:93,611,856...93,800,191
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COMMD1
copper metabolism domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17919502
NCBI chr 3:79,770,315...79,913,969
Ensembl chr 3:79,770,463...79,913,975
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CP
ceruloplasmin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513 PMID:26396155
NCBI chr13:89,396,713...89,463,540
Ensembl chr13:89,396,708...89,463,476
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CPEB1
cytoplasmic polyadenylation element binding protein 1
ISO
associated with Hepatitis C, Chronic; protein:increased expression:liver
RGD
PMID:26627607
RGD:11528851
NCBI chr 7:52,329,054...52,382,408
Ensembl chr 7:52,304,472...52,383,732
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CPEB4
cytoplasmic polyadenylation element binding protein 4
ISO
associated with Hepatitis C, Chronic; protein:increased expression:liver
RGD
PMID:26627607
RGD:11528851
NCBI chr16:50,430,345...50,499,086
Ensembl chr16:50,430,348...50,498,938
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CRP
C-reactive protein, pentraxin-related
ISO
associated with Hepatitis C, Chronic;protein:decreased expression:serum
RGD
PMID:21806828
RGD:9491781
NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218
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CSF1R
colony stimulating factor 1 receptor
exacerbates
ISO
associated with hepatitis C, liver cirrhosis;protein:increased expression:serum (human)
RGD
PMID:26437001
RGD:11079330
NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633
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CTNNB1
catenin beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21047994
NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311
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CXCL10
C-X-C motif chemokine ligand 10
disease_progression severity
ISO
mRNA:increased expression:liver associated with Chronic Hepatitis B;
RGD
PMID:11418676 PMID:28067328 PMID:29105936
RGD:27095892 RGD:27095953 RGD:27095955
NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
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CXCL14
C-X-C motif chemokine ligand 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33069761
NCBI chr 2:137,803,988...137,813,118
Ensembl chr 2:137,803,992...137,813,118
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CXCL8
C-X-C motif chemokine ligand 8
disease_progression
ISO
CTD Direct Evidence: therapeutic mRNA, protein:increased expression:liver, serum (human)
CTD RGD
PMID:15763341 PMID:21731723
RGD:26884357
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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CYBA
cytochrome b-245 alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420
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CYGB
cytoglobin
ISO
RGD
PMID:11320098 PMID:16581302
RGD:68672 RGD:9685176
NCBI chr12:4,977,245...4,988,283
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CYP1A2
cytochrome P450 family 1 subfamily A member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27565560
NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
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CYP27A1
cytochrome P450 family 27 subfamily A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24381012
NCBI chr15:120,809,886...120,852,196
Ensembl chr15:120,809,959...120,852,192
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CYP2R1
cytochrome P450 family 2 subfamily R member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24381012
NCBI chr 2:44,375,432...44,394,122
Ensembl chr 2:44,375,520...44,396,334
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CYP3A22
cytochrome P450 family 3 subfamily A member 22
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:17973928
RGD:405820211
NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817
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DGAT1
diacylglycerol O-acyltransferase 1
treatment
ISO
associated with Non-alcoholic Fatty Liver Disease;
RGD
PMID:18000880
RGD:10400849
NCBI chr 4:452,890...463,665
Ensembl chr 4:452,662...466,684
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DHCR7
7-dehydrocholesterol reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24381012
NCBI chr 2:2,377,352...2,391,846
Ensembl chr 2:2,377,416...2,391,447
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DNMT1
DNA methyltransferase 1
ISO
mRNA,protein:increased expression:liver:
RGD
PMID:24211420
RGD:9588224
NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
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DRD4
dopamine receptor D4
disease_progression
ISO
DNA:repeats:exon:
RGD
PMID:23298155
RGD:401959737
NCBI chr 2:398,766...401,539
Ensembl chr 2:398,766...402,433
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EDN1
endothelin 1
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:20628429
RGD:4144843
NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
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EGFR
epidermal growth factor receptor
severity
ISO
associated with non-alcoholic fatty liver disease;protein:increased expression:plasma
RGD
PMID:28650518
RGD:14401722
NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589
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EGR1
early growth response 1
ISO
protein:increased expression:liver, nucleus
RGD
PMID:22292946
RGD:10395298
NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
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ELN
elastin
severity
ISO
protein:increased expression:liver:
RGD
PMID:22223197
RGD:9585666
NCBI chr 3:11,214,194...11,245,891
Ensembl chr 3:11,214,205...11,244,897
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ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
ISO
associated with hepatitis C
RGD
PMID:15651265
RGD:9685530
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EPHB2
EPH receptor B2
ameliorates
ISO
associated with malaria;
RGD
PMID:25784101
RGD:127285023
NCBI chr 6:80,649,098...80,849,979
Ensembl chr 6:80,650,740...80,843,567
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F2
coagulation factor II, thrombin
severity
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:plasma (human) protein:decreased activity:plasma (human) protein:decreased expression:plasma (human)
CTD RGD
PMID:9863491 PMID:10216089 PMID:15726661 PMID:29768734
RGD:14401592 RGD:14985235 RGD:14985236
NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,455...15,819,137
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F2R
coagulation factor II thrombin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21037076
NCBI chr 2:85,642,794...85,659,133
Ensembl chr 2:85,641,474...85,656,636
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F3
coagulation factor III, tissue factor
severity treatment
ISO
mRNA, protein:increased expression, increased activity:monocyte (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9863491 PMID:10216089 PMID:15946135 PMID:21037076 PMID:28883694
RGD:11341737 RGD:14401577 RGD:14401592 RGD:14401724
NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666
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F5
coagulation factor V
susceptibility disease_progression
ISO
associated with liver fibrosis, Factor V Leiden;DNA:missense mutation:cds:rs6025 (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10520855 PMID:18485088 PMID:26226452
RGD:14700659 RGD:14700663
NCBI chr 4:81,403,273...81,484,908
Ensembl chr 4:81,403,274...81,485,066
G
FAH
fumarylacetoacetate hydrolase
ISO
RGD
PMID:27510266
RGD:14398823
NCBI chr 7:49,047,833...49,087,790
Ensembl chr 7:49,047,902...49,087,783
G
FARSB
phenylalanyl-tRNA synthetase subunit beta
ISO
ClinVar Annotator: match by term: Liver cirrhosis
ClinVar
PMID:29979980
NCBI chr15:124,472,236...124,555,042
G
FBN1
fibrillin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14661032 PMID:26396155
RGD:12910489
NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649
G
FGF19
fibroblast growth factor 19
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28673684
NCBI chr 2:3,583,027...3,586,985
Ensembl chr 2:3,582,828...3,587,752
G
FGF2
fibroblast growth factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17093919
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
G
FGF7
fibroblast growth factor 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17692400
NCBI chr 1:122,215,878...122,278,705
Ensembl chr 1:122,215,882...122,277,750
G
FGFR2
fibroblast growth factor receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17692400
NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425
G
FGFR4
fibroblast growth factor receptor 4
ISO
associated with hepatocellular carcinoma; DNA:SNP:cds: p.G388R (rs351855) (human)
RGD
PMID:25860955
RGD:11057080
NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796
G
FLT1
fms related receptor tyrosine kinase 1
ISO
mRNA:increased expressin:liver: CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11981751
RGD:634296
NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264
G
FOCAD
focadhesin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:35864190
NCBI chr 1:201,938,993...202,258,924
Ensembl chr 1:201,942,463...202,258,794
G
FOXO3
forkhead box O3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33372984
NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,218...74,760,325
G
FUBP1
far upstream element binding protein 1
ISO
associated with Chronic Hepatitis C;mRNA:increased expression:liver (human)
RGD
PMID:25995247
RGD:151361196
NCBI chr 6:135,281,474...135,319,055
Ensembl chr 6:135,281,521...135,318,714
G
GC
GC vitamin D binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24381012
NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262
G
GCH1
GTP cyclohydrolase 1
ISO
mRNA, protein:decreased expression:liver
RGD
PMID:16799985
RGD:329970289
NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,199,679...184,257,315
G
GCLC
glutamate-cysteine ligase catalytic subunit
ISO
RGD
PMID:22942279
RGD:11049542
NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
G
GDF1
growth differentiation factor 1
disease_progression
ISO
associated with Stable Angina; protein:decreased expression:blood plasma (human)
RGD
PMID:36268984
RGD:243065147
NCBI chr 2:58,972,918...58,976,294
Ensembl chr 2:58,951,726...58,974,672
G
GLI3
GLI family zinc finger 3
ISO
mRNA:increased expression:serum:
RGD
PMID:32319630
RGD:155791681
NCBI chr18:52,403,463...52,697,906
Ensembl chr18:52,404,072...52,697,900
G
GLUL
glutamate-ammonia ligase
severity
ISO
associated with congestive heart failure
RGD
PMID:30950843
RGD:401793761
NCBI chr 9:123,751,551...123,762,575
Ensembl chr 9:123,748,380...123,762,545
G
GOLM1
golgi membrane protein 1
ISO
protein:increased expression:serum
RGD
PMID:21140449
RGD:401827118
NCBI chr10:29,117,578...29,219,024
Ensembl chr10:29,118,314...29,219,018
G
GP1BA
glycoprotein Ib platelet subunit alpha
treatment
ISO
RGD
PMID:31851564
RGD:42722628
NCBI chr12:51,975,810...51,979,428
Ensembl chr12:51,975,874...51,977,757
G
GPC3
glypican 3
ISO
protein:increased expression:blood serum (human)
RGD
PMID:28801286
RGD:243065135
NCBI chr X:109,536,495...109,973,605
Ensembl chr X:109,536,504...109,973,607
G
GRK2
G protein-coupled receptor kinase 2
ISO
associated with hepatitis B;protein:increased expression:mesenteric artery (human) protein:increased expression:hepatic artery
RGD
PMID:17256744 PMID:23742775
RGD:13792718 RGD:1625784
NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758
G
HDAC2
histone deacetylase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27396813
NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585
G
HFE
homeostatic iron regulator
ISO
DNA:missense mutations: :p.H63D, p.C282Y (human)
RGD
PMID:27816425
RGD:14701047
NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000
G
HGF
hepatocyte growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17097021
NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564
G
HHIP
hedgehog interacting protein
ISO
mRNA:decreased expression:liver:
RGD
PMID:19815628
RGD:11552602
NCBI chr 8:83,583,735...83,678,368
Ensembl chr 8:83,583,739...83,679,136
G
HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36126797
NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
G
HNF4A
hepatocyte nuclear factor 4 alpha
ISO
protein:decreased expression:liver:
RGD
PMID:20876809
RGD:12904747
NCBI chr17:46,783,772...46,847,505
Ensembl chr17:46,783,777...46,847,500
G
HP
haptoglobin
ISO
associated with Hepatitis C, Chronic;protein:decreased expression:serum
RGD
PMID:21806828
RGD:9491781
NCBI chr 6:14,980,382...14,985,245
G
HRAS
HRas proto-oncogene, GTPase
ISO
mRNA:increased expression:liver (human)
RGD
PMID:7535324
RGD:14694815
NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501
G
HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15199296
NCBI chr 6:28,084,087...28,089,256
Ensembl chr 6:28,083,955...28,089,671
G
ICAM1
intercellular adhesion molecule 1
susceptibility
ISO
associated with Hepatitis B, Chronic;DNA:missense mutations, haplotype:cds:p.G241R, p.K469E (human) associated with chronic intermittent hypoxia; mRNA, protein:increased expression:liver (rat)
RGD
PMID:18233990 PMID:32626927
RGD:14402042 RGD:401959337
NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
G
IDO2
indoleamine 2,3-dioxygenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32289347
NCBI chr17:9,277,039...9,344,405
Ensembl chr17:9,277,069...9,343,749
G
IFNA1
interferon, alpha 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18665156
NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488
G
IFNG
interferon gamma
ISO
RGD
PMID:12389079 PMID:21664391
RGD:10755749 RGD:6893452
NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
G
IGF1R
insulin like growth factor 1 receptor
susceptibility
ISO
associated with Hepatis B virus;DNA:SNP:3'UTR:rs3743251(human)
RGD
PMID:24758241
RGD:14985227
NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058
G
IGF2
insulin like growth factor 2
severity
ISO
associated with non-alcoholic fatty liver disease;protein:decreased expression:plasma
RGD
PMID:28650518
RGD:14401722
NCBI chr 2:1,469,183...1,496,417
G
IGFBP1
insulin like growth factor binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr18:50,018,487...50,022,799
Ensembl chr18:50,018,487...50,022,799
G
IGFBP2
insulin like growth factor binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
G
IL10
interleukin 10
no_association severity
ISO
associated with Hepatitis C, Chronic;DNA:SNP:promoter:-1082 G>A (human) DNA:SNP:promoter:-1082G>A (rs1800896) (human) associated with Hepatitis C, Chronic;DNA:SNP:promoter:-592C>A (human) DNA:SNP:promoter:-592C>A (rs1800872) (human)
RGD
PMID:26909998 PMID:27660094
RGD:14975134 RGD:14975152
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
G
IL18
interleukin 18
severity
ISO
associated with Hepatitis C, Chronic;mRNA:increased expression:PBMC: protein:increased expression:plasma:
RGD
PMID:12462332 PMID:19740312
RGD:14695542 RGD:14696656
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
G
IL18BP
interleukin 18 binding protein
disease_progression
ISO
protein:increased expression:plasma:
RGD
PMID:12462332
RGD:14695542
NCBI chr 9:6,586,602...6,596,423
Ensembl chr 9:6,488,808...6,591,333
G
IL1RL1
interleukin 1 receptor like 1
severity
ISO
associated with Schistosomiasis Japonica
RGD
PMID:31200771
RGD:39938956
NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,846,792...51,951,383
G
IL2
interleukin 2
treatment
ISO
associated with sclerosing cholangitis
RGD
PMID:29698570
RGD:14928214
NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
G
IL21
interleukin 21
exacerbates
ISO
associated with Chronic Hepatitis B;mRNA:increased expression: liver (human)
RGD
PMID:24611989
RGD:127285546
NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713
G
IL27
interleukin 27
ISO
associated with hepatitis B;protein:increased expression:blood serum (human)
RGD
PMID:22230324
RGD:126790507
NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915
G
IL28B
interleukin 28B (interferon, lambda 3)
treatment
ISO
associated with Hepatitis C;DNA:SNP: :rs8099917 (human)
RGD
PMID:23145809
RGD:11528558
NCBI chr 6:47,951,925...47,953,282
Ensembl chr 6:47,951,595...47,953,467
G
IL33
interleukin 33
severity
ISO
associated with Schistosomiasis Japonica
RGD
PMID:31053540 PMID:31200771
RGD:39938956 RGD:40400690
NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840
G
IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12830005
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
IRF5
interferon regulatory factor 5
severity
ISO
RGD
PMID:27942586
RGD:40924562
NCBI chr18:19,678,377...19,691,154
Ensembl chr18:19,678,687...19,691,243
G
ITGB6
integrin subunit beta 6
disease_progression
ISO
associated with Hepatitis C, Chronic;mRNA:increased expression:liver
RGD
PMID:18221819
RGD:2302245
NCBI chr15:67,041,516...67,175,409
Ensembl chr15:67,041,522...67,175,234
G
ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
associated with hepatitis B;protein:increased expression:serum
RGD
PMID:24836184
RGD:40903002
NCBI chr13:34,928,455...34,948,250
Ensembl chr13:34,928,439...34,948,229
G
JAK1
Janus kinase 1
treatment
ISO
associated with Schistosomiasis Japonica
RGD
PMID:27439782
RGD:19165137
NCBI chr 6:147,320,288...147,567,188
Ensembl chr 6:147,429,056...147,567,182
G
JAK2
Janus kinase 2
severity
ISO
mRNA:increased expression:liver (human)
RGD
PMID:26385087
RGD:18337263
NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148
G
JUND
JunD proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17133482
NCBI chr 2:59,530,991...59,532,846
G
KDR
kinase insert domain receptor
disease_progression
ISO
associated with Chronic Hepatitis
RGD
PMID:27323788
RGD:126908000
NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336
G
KLF5
KLF transcription factor 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33549628
NCBI chr11:45,370,009...45,386,673
Ensembl chr11:45,369,810...45,388,314
G
KLKB1
kallikrein B1
ISO
RGD
PMID:14986822
RGD:7297050
NCBI chr15:47,071,581...47,100,272
Ensembl chr15:47,071,556...47,103,622
G
KRT18
keratin 18
severity
ISO
protein:H127L CTD Direct Evidence: therapeutic protein:increased expression: serum (human)
RGD CTD
PMID:9011570 PMID:20538000 PMID:29023872
RGD:1624318 RGD:18337484
NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429
G
KRT8
keratin 8
ISO
CTD Direct Evidence: therapeutic protein:increased phosphorylation:liver (human)
CTD RGD
PMID:11372009 PMID:15368451 PMID:20538000
RGD:14401583 RGD:1600062
NCBI chr 5:18,172,423...18,180,277
Ensembl chr 5:18,167,553...18,180,404
G
LAMC2
laminin subunit gamma 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 9:124,427,545...124,499,672
Ensembl chr 9:124,435,807...124,495,351
G
LBP
lipopolysaccharide binding protein
ISO
protein:increased expression:liver
RGD
PMID:17918268
RGD:2292126
NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,398,791...41,429,551
G
LDLR
low density lipoprotein receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36108984
NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827
G
LGALS1
galectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 5:10,149,069...10,152,514
Ensembl chr 5:10,149,068...10,156,023
G
LGALS3
galectin 3
ISO
RGD
PMID:16549783
RGD:9685224
NCBI chr 1:184,478,639...184,496,155
Ensembl chr 1:184,478,710...184,497,951
G
LGALS3BP
galectin 3 binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr12:3,212,435...3,222,651
Ensembl chr12:3,212,432...3,222,711
G
LOC102161030
interferon lambda-4
disease_progression treatment
ISO
DNA:SNPs:5'utr: (rs12979860,rs8099917)(human) associated with Hepatitis C, Chronic; DNA:SNP:5'utr: (rs12979860) (human)
RGD
PMID:25740255 PMID:29534310
RGD:40400752 RGD:40400910
NCBI chr 6:47,946,679...47,948,710
G
LOC110258578
interleukin-1 beta-like
ISO
associated with chronic intermittent hypoxia; mRNA, protein:increased expression:liver (rat)
RGD
PMID:32626927
RGD:401959337
G
LOX
lysyl oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 2:125,595,115...125,607,026
Ensembl chr 2:125,591,789...125,607,594
G
LOXL1
lysyl oxidase like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30097701
NCBI chr 7:59,481,410...59,505,161
Ensembl chr 7:59,481,412...59,505,149
G
LUM
lumican
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 5:91,748,871...91,756,381
Ensembl chr 5:91,748,885...91,757,598
G
MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
ISO
protein:increased expression:skeletal muscle
RGD
PMID:22895779
RGD:11561934
NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
G
MAPK14
mitogen-activated protein kinase 14
exacerbates
ISO
RGD
PMID:23271722
RGD:151665348
NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031
G
MBL2
mannose binding lectin 2
susceptibility severity
ISO
associated with hepatitis B;DNA:SNP:exon: associated with hepatitis C; DNA:haplotype:promoter, exon:
RGD
PMID:20570631 PMID:26857650
RGD:14696832 RGD:14696836
NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083
G
MGLL
monoglyceride lipase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:30301768
NCBI chr13:72,480,395...72,568,964
Ensembl chr13:72,480,174...72,568,961
G
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32659284
NCBI chr 2:47,042,475...47,302,087
Ensembl chr 2:47,131,832...47,302,117
G
MIR122
microRNA mir-122
ISO
mRNA:decreased expression:blood (human)
RGD
PMID:27528885
RGD:151361113
NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
G
MIR126
microRNA mir-126
ISO
RNA:increased expression:duodenum
RGD
PMID:22574900
RGD:401850781
G
MIR145
microRNA mir-145
ISO
miRNA:decreased expression:liver (human)
RGD
PMID:27289031
RGD:15039397
NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211
G
MIR152
microRNA mir-152
ISO
miRNA:decreased expression:serum
RGD
PMID:31258681
RGD:19165153
NCBI chr12:24,292,249...24,292,328
Ensembl chr12:24,292,251...24,292,336
G
MIR155
microRNA mir-155
ISO
RGD
PMID:29420849
RGD:21409750
NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902
G
MIR193A
microRNA mir-193a
ISO
associated with hepatocellular carcinoma; RNA:decreased expression:liver (human)
RGD
PMID:24330766
RGD:153344567
NCBI chr12:43,336,969...43,337,048
Ensembl chr12:43,336,969...43,337,048
G
MIR21
microRNA mir-21
onset treatment disease_progression ameliorates
ISO
associated with nonalcoholic fatty liver disease;miRNA:increased expression:liver, plasma associated with chronic hepatitis B
RGD
PMID:20625373 PMID:26946098 PMID:27320964 PMID:30147020 PMID:30419452
RGD:14695024 RGD:40925947 RGD:41404667 RGD:41404701 RGD:41404717
NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
G
MIR221
microRNA mir-221
ISO
RNA:increased expression:liver
RGD
PMID:22267590
RGD:151709001
NCBI chr X:40,571,068...40,571,137
Ensembl chr X:40,571,068...40,571,137
G
MIR222
microRNA mir-222
ISO
RNA:increased expression:liver
RGD
PMID:22267590
RGD:151709001
NCBI chr X:40,571,808...40,571,887
Ensembl chr X:40,571,808...40,571,887
G
MIR29C
microRNA mir-29c
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 9:135,019,638...135,019,725
Ensembl chr 9:135,019,638...135,019,725
G
MIR30A
microRNA mir-30a
ISO
RNA:decreased expression:liver
RGD
PMID:29587268
RGD:35673290
NCBI chr 1:51,412,827...51,412,933
Ensembl chr 1:51,412,827...51,412,933
G
MIR30B
microRNA mir-30b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 4:6,952,794...6,952,869
Ensembl chr 4:6,952,794...6,952,869
G
MIR30C-1
microRNA mir-30c-1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 6:170,426,781...170,426,860
Ensembl chr 6:170,426,781...170,426,860
G
MIR30C-2
microRNA mir-30c-2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22363424
NCBI chr 1:51,383,782...51,383,861
Ensembl chr 1:51,383,782...51,383,861
G
MIR345-1
microRNA mir-345-1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36126797
NCBI chr 7:121,193,720...121,193,799
Ensembl chr 7:121,193,716...121,193,799
G
MIR885
microRNA mir-885
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27738331
NCBI chr13:66,597,531...66,597,610
Ensembl chr13:66,597,531...66,597,610
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MMP1
matrix metallopeptidase 1
severity
ISO
protein:decreased expression:serum (rat)
RGD
PMID:14606082 PMID:16124044
RGD:7207132 RGD:7207396
NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,420,076
G
MMP13
matrix metallopeptidase 13
ISO
RGD
PMID:21382168
RGD:7207361
NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162
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MMP2
matrix metallopeptidase 2
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15763341 PMID:23411180 PMID:26396155
RGD:8657103
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
G
MPO
myeloperoxidase
disease_progression
ISO
DNA:SNP:promoter:-463G>A( rs2333227)(human)
RGD
PMID:19731237
RGD:26923907
NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904
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MRTFA
myocardin related transcription factor A
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:33779332
NCBI chr 5:7,751,350...7,975,927
Ensembl chr 5:7,959,312...7,972,574
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MTHFR
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNP: :677C>T(human)
RGD
PMID:25987440
RGD:14696749
NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
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MUC2
mucin 2, oligomeric mucus/gel-forming
ISO
mRNA:increased expression:ileum
RGD
PMID:22172882
RGD:7349362
NCBI chr 2:689,363...719,542
Ensembl chr 2:689,364...710,330
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MYC
MYC proto-oncogene, bHLH transcription factor
ISO
mRNA,protein:increased expression:liver
RGD
PMID:23770341
RGD:14695015
NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
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NFE2L2
NFE2 like bZIP transcription factor 2
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:22732220 PMID:23793039
RGD:10412731
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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NOS3
nitric oxide synthase 3
treatment
ISO
protein:decreased activity:liver (rat)
RGD
PMID:10535886 PMID:12759254
RGD:7775034 RGD:7794774
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
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NPC1
NPC intracellular cholesterol transporter 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22216111
NCBI chr 6:108,403,126...108,450,486
Ensembl chr 6:108,402,879...108,450,990
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NPPA
natriuretic peptide A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15613622
NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,918,845...71,921,405
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NPPB
natriuretic peptide B
severity
ISO
protein:increased expression:plasma protein:increased expression:plasma:
RGD
PMID:9350073 PMID:23940514
RGD:7246914 RGD:7248670
NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,930,382...71,932,254
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NQO1
NAD(P)H quinone dehydrogenase 1
treatment
ISO
RGD
PMID:29078262
RGD:13442479
NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
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NR1H4
nuclear receptor subfamily 1 group H member 4
severity treatment
ISO
mRNA:altered expression:liver (mouse) mRNA:altered expression:liver, kidney (rat)
RGD
PMID:19418582 PMID:30308196
RGD:15042865 RGD:15042868
NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604
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P2RX7
purinergic receptor P2X 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32721574
NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472
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PARP1
poly(ADP-ribose) polymerase 1
ISO
associated with Hepatitis B;mRNA:decreased expression:blood, mononuclear cell
RGD
PMID:25755481
RGD:11073733
NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
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PCOLCE
procollagen C-endopeptidase enhancer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 3:8,523,455...8,528,749
Ensembl chr 3:8,523,449...8,528,739
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PDCD10
programmed cell death 10
ISO
protein:increased expression:liver (human)
RGD
PMID:32186778
RGD:401827111
NCBI chr13:106,517,408...106,558,959
Ensembl chr13:106,517,432...106,558,895
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PDGFA
platelet derived growth factor subunit A
ISO
ClinVar Annotator: match by term: Hepatic fibrosis
ClinVar
PMID:25741868
NCBI chr 3:296,399...322,967
Ensembl chr 3:301,584...321,712
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PDGFB
platelet derived growth factor subunit B
ISO
mRNA: increased expression
RGD
PMID:22407906 PMID:22539040
RGD:6482830 RGD:6482858
Ensembl chr 5:8,986,462...9,007,435
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PDGFD
platelet derived growth factor D
ISO
mRNA,protein:increased expression:liver:
RGD
PMID:17397961
RGD:9854631
NCBI chr 9:34,388,636...34,621,227
Ensembl chr 9:34,388,643...34,621,244
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PDIA3
protein disulfide isomerase family A member 3
severity
ISO
protein:decreased expression:liver:
RGD
PMID:24562544
RGD:9999176
NCBI chr 1:127,786,174...127,814,096
Ensembl chr 1:127,785,772...127,814,196
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PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
protein:increased expression:blood microparticle (human)
RGD
PMID:22465620
RGD:6771231
NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293
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PEMT
phosphatidylethanolamine N-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29416063
NCBI chr12:60,880,367...60,919,279
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PGF
placental growth factor
ISO
mRNA, protein:increased expression:liver, serum
RGD
PMID:21520176
RGD:6483607
NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741
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PHKG2
phosphorylase kinase catalytic subunit gamma 2
ISO
DNA:missense mutation, nonsense mutation (human)
RGD
PMID:9384616
RGD:737725
NCBI chr 3:17,640,790...17,656,765
Ensembl chr 3:17,639,996...17,656,618
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PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
treatment
ISO
associated with Schistosomiasis Japonica
RGD
PMID:29323718
RGD:38599216
NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
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PKHD1
PKHD1 ciliary IPT domain containing fibrocystin/polyductin
ISO
DNA:deletion:exon:
RGD
PMID:17519956
RGD:14700917
NCBI chr 7:45,447,354...45,925,141
Ensembl chr 7:45,450,950...45,925,149
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:18481824 PMID:26396155
NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
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PLAUR
plasminogen activator, urokinase receptor
disease_progression
ISO
protein:increased expression:serum
RGD
PMID:22098627
RGD:6484116
NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
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PLOD2
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr13:86,402,673...86,513,167
Ensembl chr13:86,401,244...86,513,105
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PNPLA3
patatin like phospholipase domain containing 3
severity disease_progression
ISO
associated with type 2 diabetes mellitus;DNA:SNP: :rs738409 (p.I148M) (human) associated with non-alcoholic fatty liver disease:DNA:SNP: :rs738409 (p.I148M) (human) associated with Hepatitis C, Chronic;DNA:SNP: :rs738409 (p.I148M) (human)
RGD
PMID:20648474 PMID:29674183 PMID:31377187
RGD:14981584 RGD:14981591 RGD:14981594
NCBI chr 5:5,075,608...5,092,599
Ensembl chr 5:5,075,622...5,092,515
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POSTN
periostin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32344006
NCBI chr11:13,225,183...13,258,973
Ensembl chr11:13,224,959...13,258,978
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PPP1R16A
protein phosphatase 1 regulatory subunit 16A
severity
ISO
associated with Hepatitis B, Chronic;
RGD
PMID:30665287
RGD:14975252
NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056
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PTEN
phosphatase and tensin homolog
ISO
CTD Direct Evidence: marker/mechanism associated with schistosomiasis;protein, mRNA:decreased expression:liver (mouse)
CTD RGD
PMID:26023714 PMID:31907686
RGD:127285596
NCBI chr14:99,929,590...100,021,619
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PTGS2
prostaglandin-endoperoxide synthase 2
severity
ISO
human gene in mouse model
RGD
PMID:29109031
RGD:14695008
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
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PTN
pleiotrophin
ISO
protein:increased expression:liver (rat)
RGD
PMID:18381592
RGD:9834946
NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,787...12,309,044
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RAD50
RAD50 double strand break repair protein
treatment
ISO
RGD
PMID:21893185
RGD:9831391
NCBI chr 2:134,844,460...134,939,188
Ensembl chr 2:134,700,817...134,939,189
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RBP4
retinol binding protein 4
severity
ISO
associated with lived disease; protein:decreased expression:blood serum (human)
RGD
PMID:17337499
RGD:329845879
NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765
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RELA
RELA proto-oncogene, NF-kB subunit
ISO
associated with chronic intermittent hypoxia; mRNA, protein:increased expression:liver (rat)
RGD
PMID:32626927
RGD:401959337
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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RELN
reelin
ISO
protein:altered expression:plasma (human)
RGD
PMID:18449964
RGD:2317777
NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,863...103,963,883
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REN
renin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15613622
NCBI chr 9:64,809,143...64,822,605
Ensembl chr 9:64,809,146...64,822,658
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RGN
regucalcin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr X:41,725,660...41,749,736
Ensembl chr X:41,726,526...41,749,381
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RGS2
regulator of G protein signaling 2
ISO
RGD
PMID:19003918
RGD:10449440
NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
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SERPINA1
serpin family A member 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:3485248 PMID:20511674 PMID:20522742 PMID:25579632
RGD:14695525
NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,583,043...115,614,645
G
SERPINA6
serpin family A member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 7:115,535,552...115,554,536
Ensembl chr 7:115,535,697...115,554,570
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SERPINE1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:
RGD
PMID:25987440
RGD:14696749
NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
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SERPING1
serpin family G member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr 2:13,324,160...13,338,826
Ensembl chr 2:13,324,158...13,338,663
G
SERPINH1
serpin family H member 1
disease_progression treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Schistosomiasis Japonica associated with Schistosomiasis Japonica;mRNA:increased expression:liver (human) associated with schistosomiasis;mRNA:increased expression:liver (human)
CTD RGD
PMID:24295791 PMID:24321339 PMID:25111595 PMID:31612672 PMID:32410640
RGD:41410780 RGD:41410784 RGD:41410785 RGD:41412161
NCBI chr 9:9,782,939...9,794,485
Ensembl chr 9:9,783,042...9,794,483
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SHC1
SHC adaptor protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:32659284
NCBI chr 4:94,818,226...94,831,766
Ensembl chr 4:94,810,875...94,831,765
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SLC13A4
solute carrier family 13 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr18:13,593,735...13,641,649
Ensembl chr18:13,593,756...13,636,180
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SLC17A2
solute carrier family 17 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 7:20,596,547...20,663,498
Ensembl chr 7:20,644,244...20,663,423
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SLC22A8
solute carrier family 22 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:8,782,030...8,800,998
Ensembl chr 2:8,782,060...8,800,997
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SLC30A10
solute carrier family 30 member 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22926781
NCBI chr10:9,527,523...9,545,493
G
SLC6A4
solute carrier family 6 member 4
susceptibility
ISO
associated with alcohol use disorder;DNA:deletion:promoter:-1212_-1255 (human)
RGD
PMID:11236836
RGD:36947396
NCBI chr12:46,285,995...46,328,377
Ensembl chr12:46,285,997...46,314,378
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SMAD3
SMAD family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21605584
NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449
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SMAD7
SMAD family member 7
ISO
associated with hepatocellular carcinoma; mRNA:increased expression:liver (human)
RGD
PMID:25602745
RGD:14401589
NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382
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SMO
smoothened, frizzled class receptor
treatment
ISO
RGD
PMID:22994359
RGD:150521663
NCBI chr18:19,450,730...19,478,796
Ensembl chr18:19,450,743...19,478,898
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SOCS1
suppressor of cytokine signaling 1
exacerbates
ISO
associated with Chemical and Drug Induced Liver Injury;
RGD
PMID:30097285
RGD:150573810
NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967
G
SOD2
superoxide dismutase 2
disease_progression
ISO
DNA:SNP:cds:p.Ala16Val(rs1799725)(human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19731237 PMID:32659284
RGD:26923907
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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SPAG9
sperm associated antigen 9
ISO
associated with Human Viral Hepatitis
RGD
PMID:29344208
RGD:30296654
NCBI chr12:27,225,377...27,370,337
Ensembl chr12:27,202,088...27,370,405
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SPARC
secreted protein acidic and cysteine rich
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23408952
NCBI chr16:71,368,164...71,380,972
Ensembl chr16:71,357,586...71,381,161
G
SPINT1
serine peptidase inhibitor, Kunitz type 1
ISO
mRNA:increased expression:spleen:
RGD
PMID:15086199
RGD:10043112
NCBI chr 1:130,458,909...130,473,791
Ensembl chr 1:130,458,909...130,473,783
G
SPP1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16221502
NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
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STAT1
signal transducer and activator of transcription 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17133483
NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
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STAT3
signal transducer and activator of transcription 3
ISO
RGD
PMID:22687286
RGD:6892914
NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992
G
TAGLN2
transgelin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 4:90,566,272...90,574,762
G
TFPI
tissue factor pathway inhibitor
ISO
RGD
PMID:23841464
RGD:11060135
NCBI chr15:92,345,083...92,409,962
Ensembl chr15:92,345,075...92,409,905
G
TGFB1
transforming growth factor beta 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21037076 PMID:30686515 PMID:35101388 PMID:36368619
RGD:14985228
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
G
TGFB2
transforming growth factor beta 2
ISO
RGD
PMID:30686515
RGD:14985228
NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341
G
TGFBR1
transforming growth factor beta receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28560358
NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,860,156...240,918,528
G
TGM2
transglutaminase 2
severity treatment
ISO
associated with Schistosomiasis Japonica
RGD
PMID:31200771
RGD:39938956
NCBI chr17:41,186,765...41,221,686
Ensembl chr17:41,186,770...41,221,637
G
THBS1
thrombospondin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18407596
NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115
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THPO
thrombopoietin
ISO
mRNA:decreased expression:liver
RGD
PMID:9794189
RGD:1580082
NCBI chr13:122,259,654...122,267,860
Ensembl chr13:122,260,215...122,267,860
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TLR2
toll like receptor 2
ISO
RGD
PMID:24815695
RGD:15090811
NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330
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TLR3
toll like receptor 3
susceptibility
ISO
DNA:snp: :rs3775290(human)
RGD
PMID:26024592
RGD:21079416
NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291
G
TLR4
toll like receptor 4
treatment
ISO
protein:increased expression:intestine: associated with chronic intermittent hypoxia
RGD
PMID:20006396 PMID:26809353 PMID:27061671 PMID:32626927
RGD:14697732 RGD:14700654 RGD:18182934 RGD:401959337
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
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TMEM67
transmembrane protein 67
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19508969
NCBI chr 4:42,878,249...42,931,106
Ensembl chr 4:42,879,140...42,931,121
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TNF
tumor necrosis factor
severity
ISO
protein:increased expression:serum (human) associated with chronic intermittent hypoxia; mRNA, protein:increased expression:liver (rat)
RGD
PMID:19695831 PMID:32626927
RGD:14995448 RGD:401959337
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
G
TNFRSF1B
TNF receptor superfamily member 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20353583
NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147
G
TRPM7
transient receptor potential cation channel subfamily M member 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25150141
NCBI chr 1:121,146,093...121,250,227
Ensembl chr 1:121,146,117...121,250,224
G
UNC93B1
unc-93 homolog B1, TLR signaling regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513
NCBI chr 2:4,898,414...4,909,833
Ensembl chr 2:4,898,409...4,909,856
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VASH1
vasohibin 1
treatment
ISO
associated with Hepatitis C, Chronic; protein:increased expression:liver
RGD
PMID:24390792
RGD:15003198
NCBI chr 7:99,910,644...99,933,633
Ensembl chr 7:99,910,497...99,929,770
G
VCAM1
vascular cell adhesion molecule 1
ISO
associated with chronic intermittent hypoxia; mRNA, protein:increased expression:liver (rat)
RGD
PMID:32626927
RGD:401959337
NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
G
VDR
vitamin D receptor
severity
ISO
associated with nonalcoholic fatty liver disease; DNA:SNP: :rs1544410(human)
RGD
PMID:23622244 PMID:30218108 PMID:30683615
RGD:14401752 RGD:14402027 RGD:14402031
NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475
G
VEGFA
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:platelet: associated with Hepatitis C, Chronic; protein:increased expression:liver
CTD RGD
PMID:11981751 PMID:18544126 PMID:26627607
RGD:11528851 RGD:15003200
NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
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VEGFC
vascular endothelial growth factor C
ISO
protein:increased expression:liver:
RGD
PMID:18544126
RGD:15003200
NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,039,311...39,132,936
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VIM
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25226513 PMID:26396155 PMID:32659284
NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,170
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VTN
vitronectin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26396155
NCBI chr12:44,650,532...44,653,916
Ensembl chr12:44,650,534...44,655,355
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WDR35
WD repeat domain 35
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:18472094
RGD:11553927
NCBI chr 3:118,209,112...118,279,050
Ensembl chr 3:118,209,139...118,269,452
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XRCC1
X-ray repair cross complementing 1
susceptibility
ISO
associated with Human Viral Hepatitis;DNA:missense mutation:cds:p.R399Q (rs25487) (human) associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R194W (human) associated with hepatitis B;DNA:missense mutation, haplotype:cds:p.R399Q (human)
RGD
PMID:23454624 PMID:24018491 PMID:29935355
RGD:14985244 RGD:15036794 RGD:15036797
NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729
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ALDH2
aldehyde dehydrogenase 2 family member
susceptibility
ISO
DNA:missense mutation:cds:p.E504K (human) DNA:missense mutation:cds: (rs671) (human) associated with alcohol dependence;DNA:missense mutation:exon 12:p.E487K (human)
RGD
PMID:11051375 PMID:23550892 PMID:29779728
RGD:14696777 RGD:15042858 RGD:15042864
NCBI chr14:39,902,317...39,933,113
Ensembl chr14:39,896,565...39,933,124
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BCL2
BCL2 apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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C3
complement C3
ISO
RGD
PMID:9176087
RGD:408418722
NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228
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CAT
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
ISO
protein:decreased expression:brain
RGD
PMID:16205370
RGD:6483345
NCBI chr12:20,758,081...20,765,655
Ensembl chr12:20,758,083...20,765,553
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COL3A1
collagen type III alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,526,603...93,596,363
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CRP
C-reactive protein, pentraxin-related
severity
ISO
RGD
PMID:22441510
RGD:6482305
NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20843640 PMID:29404441
RGD:14700873
NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
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DDR1
discoidin domain receptor tyrosine kinase 1
severity
ISO
mRNA:increased expression:liver (human)
RGD
PMID:33173221
RGD:151347691
NCBI chr 7:23,371,358...23,391,585
Ensembl chr 7:23,373,777...23,391,585
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DDR2
discoidin domain receptor tyrosine kinase 2
disease_progression ameliorates
ISO
RGD
PMID:21199726 PMID:23409069
RGD:150429766 RGD:150517731
NCBI chr 4:87,749,738...87,911,818
Ensembl chr 4:87,756,168...87,911,296
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FABP2
fatty acid binding protein 2
onset
ISO
DNA:polymorphism:CDS:amino acid A54T, homozygosity of the T allele associated with later onset
RGD
PMID:16289894
RGD:1578455
NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480
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GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
susceptibility
ISO
DNA:SNP:intron 8:84435G>A (human)
RGD
PMID:19428381
RGD:402463950
NCBI chr16:61,441,622...61,543,375
Ensembl chr16:61,441,632...61,543,361
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HAPLN4
hyaluronan and proteoglycan link protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26482880
NCBI chr 2:58,617,210...58,627,785
Ensembl chr 2:58,617,205...58,626,805
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IL18BP
interleukin 18 binding protein
ISO
protein:increased expression:plasma:
RGD
PMID:15566508
RGD:14696666
NCBI chr 9:6,586,602...6,596,423
Ensembl chr 9:6,488,808...6,591,333
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IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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JAK2
Janus kinase 2
ISO
mRNA, protein:increased expression, increased tyrosine phosphorylation:liver
RGD
PMID:24619965
RGD:10403061
NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148
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LEP
leptin
ISO
DNA:hypomethylation:promoter (human)
RGD
PMID:29912265
RGD:21201248
NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323
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MBOAT7
membrane bound O-acyltransferase domain containing 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26482880
NCBI chr 6:55,939,456...55,955,746
Ensembl chr 6:55,939,451...55,955,736
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MIR122
microRNA mir-122
ISO
miRNA:decreased expression:liver
RGD
PMID:28987423
RGD:14401600
NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
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MIR17
microRNA mir-17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr11:60,734,656...60,734,732
Ensembl chr11:60,734,656...60,734,732
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MIR421
microRNA mir-421
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:59,550,992...59,551,069
Ensembl chr X:59,550,987...59,551,071
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MIR423
microRNA mir-423
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr12:46,211,525...46,211,604
Ensembl chr12:46,211,525...46,211,611
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MIR532
microRNA mir-532
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr X:43,705,258...43,705,337
Ensembl chr X:43,705,258...43,705,337
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MIR885
microRNA mir-885
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28545106
NCBI chr13:66,597,531...66,597,610
Ensembl chr13:66,597,531...66,597,610
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MMP13
matrix metallopeptidase 13
ISO
RGD
PMID:16286264
RGD:10043176
NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162
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MMP2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
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MPO
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19731237 PMID:23274713
NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904
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MTHFR
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNP: :677C>T(human)
RGD
PMID:25987440
RGD:14696749
NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
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NR1D1
nuclear receptor subfamily 1 group D member 1
ISO
RGD
PMID:24497272
RGD:10448995
NCBI chr12:22,263,549...22,274,131
Ensembl chr12:22,263,657...22,271,643
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PLAU
plasminogen activator, urokinase
ISO
RGD
PMID:19615318
RGD:7241800
NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
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PNPLA3
patatin like phospholipase domain containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19946271 PMID:26482880
NCBI chr 5:5,075,608...5,092,599
Ensembl chr 5:5,075,622...5,092,515
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RELA
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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SERPINE1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:
RGD
PMID:25987440
RGD:14696749
NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
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SERPINF1
serpin family F member 1
ISO
protein:increased expression:serum (human)
RGD
PMID:27748324
RGD:27226704
NCBI chr12:47,949,004...47,959,471
Ensembl chr12:47,948,510...47,959,470
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SMAD3
SMAD family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449
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SOD2
superoxide dismutase 2
susceptibility
ISO
DNA:SNP: : 47T>C(human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19731237 PMID:26873981
RGD:11060603
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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TG
thyroglobulin
ISO
RGD
PMID:6883738
RGD:401976502
NCBI chr 4:8,158,395...8,382,435
Ensembl chr 4:8,158,396...8,382,435
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TGFB1
transforming growth factor beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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TIMP1
TIMP metallopeptidase inhibitor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr X:42,103,251...42,106,289
Ensembl chr X:42,102,172...42,106,296
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TLR9
toll like receptor 9
ISO
protein:increased expression:blood, neutrophil (human)
RGD
PMID:18433921
RGD:5130706
NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23274713
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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AQP4
aquaporin 4
ISO
RGD
PMID:20680636
RGD:5148026
NCBI chr 6:111,407,632...111,422,169
Ensembl chr 6:111,407,639...111,422,109
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EDAR
ectodysplasin A receptor
ISO
ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy
ClinVar
PMID:10431241 PMID:18231121 PMID:20236127 PMID:20979233 PMID:25741868 PMID:28492532 More...
NCBI chr 3:47,396,303...47,466,234
Ensembl chr 3:47,396,330...47,465,784
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FANCI
FA complementation group I
ISO
ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy
ClinVar
PMID:15477547 PMID:15689359 PMID:16177225 PMID:16621917 PMID:17088268 PMID:17426723 PMID:17438011 PMID:17452773 PMID:17460694 PMID:17950645 PMID:17980715 PMID:18414213 PMID:18546365 PMID:18991199 PMID:19010300 PMID:19538466 PMID:20691285 PMID:21038416 PMID:21228398 PMID:21880868 PMID:22189570 PMID:23430898 PMID:23524600 PMID:23783014 PMID:24033266 PMID:24086434 PMID:25462018 PMID:25741868 PMID:26104464 PMID:26467025 PMID:27987238 PMID:28492532 PMID:30423451 PMID:30634555 PMID:31655921 PMID:33486010 PMID:35478072 More...
NCBI chr 7:54,811,024...54,889,992
Ensembl chr 7:54,811,027...54,889,998
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LOC100511376
E3 SUMO-protein ligase RanBP2
ISO
ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy
ClinVar
PMID:10431241 PMID:18231121 PMID:20236127 PMID:20979233 PMID:25741868 PMID:28492532 More...
NCBI chr 3:47,531,362...47,601,328
Ensembl chr 3:47,531,359...47,601,495
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POLG
DNA polymerase gamma, catalytic subunit
susceptibility
ISO
ClinVar Annotator: match by term: Alpers Syndrome | ClinVar Annotator: match by term: Alpers-Huttenlocher Syndrome | ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 4a | ClinVar Annotator: match by term: Neuronal degeneration of childhood with liver disease, progressive | ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy ClinVar Annotator: match by term: Alpers disease | ClinVar Annotator: match by term: Alpers-Huttenlocher Syndrome | ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 4a | ClinVar Annotator: match by term: Neuronal degeneration of childhood with liver disease, progressive | ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy ClinVar Annotator: match by term: Alpers progressive infantile poliodystrophy | ClinVar Annotator: match by term: Alpers-Huttenlocher Syndrome | ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 4a | ClinVar Annotator: match by term: Neuronal degeneration of childhood with liver disease, progressive | ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy ClinVar Annotator: match by term: Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis | ClinVar Annotator: match by term: Alpers-Huttenlocher Syndrome | ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 4A (Alpers type) | ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 4a | ClinVar Annotator: match by term: Neuronal degeneration of childhood with liver disease, progressive | ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy ClinVar Annotator: match by term: Alpers diffuse degeneration of cerebral gray matter with hepatic cirrhosis | ClinVar Annotator: match by term: Alpers-Huttenlocher Syndrome | ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 4a | ClinVar Annotator: match by term: Neuronal degeneration of childhood with liver disease, progressive | ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy DNA:missense mutation:cds:p.P1073L (3218C>T) (human)
OMIM ClinVar RGD
PMID:632821 PMID:1539879 PMID:1582434 PMID:1858914 PMID:2067633 PMID:2392416 PMID:2504279 PMID:2725645 PMID:7847370 PMID:9500334 PMID:9536098 PMID:11301032 PMID:11431686 PMID:11555352 PMID:11571332 PMID:11897778 PMID:12073019 PMID:12210792 PMID:12297582 PMID:12565911 PMID:12707443 PMID:12825077 PMID:12872260 PMID:12975295 PMID:14467368 PMID:14557557 PMID:14635118 PMID:14694057 PMID:14745080 PMID:15122711 PMID:15181170 PMID:15258572 PMID:15349879 PMID:15351195 PMID:15477547 PMID:15534189 PMID:15689359 PMID:15800909 PMID:15824347 PMID:15913923 PMID:15917273 PMID:15929042 PMID:16024923 PMID:16080118 PMID:16130100 PMID:16177225 PMID:16199547 PMID:16368709 PMID:16401742 PMID:16545482 PMID:16595552 PMID:16621917 PMID:16634032 PMID:16638794 PMID:16639411 PMID:16682683 PMID:16715201 PMID:16857757 PMID:16896309 PMID:16919951 PMID:16929381 PMID:16940310 PMID:16943369 PMID:16957900 PMID:17067213 PMID:17088268 PMID:17280874 PMID:17310215 PMID:17418573 PMID:17426723 PMID:17436221 PMID:17438011 PMID:17452231 PMID:17452773 PMID:17460694 PMID:17502560 PMID:17538929 PMID:17576681 PMID:17725985 PMID:17846414 PMID:17894835 PMID:17923349 PMID:17950645 PMID:17980715 PMID:18156159 PMID:18195149 PMID:18195151 PMID:18294203 PMID:18321754 PMID:18414213 PMID:18446447 PMID:18487244 PMID:18500570 PMID:18546343 PMID:18546365 PMID:18585914 PMID:18716558 PMID:18783964 PMID:18828154 PMID:18991199 PMID:19010300 PMID:19103152 PMID:19125351 PMID:19189930 PMID:19195941 PMID:19251978 PMID:19275594 PMID:19307547 PMID:19344718 PMID:19364868 PMID:19478085 PMID:19500334 PMID:19501198 PMID:19538466 PMID:19566497 PMID:19578034 PMID:19629138 PMID:19752458 PMID:19762913 PMID:19766516 PMID:19813183 PMID:19815814 PMID:19837034 PMID:19862739 PMID:19887119 PMID:20138553 PMID:20142534 PMID:20153822 PMID:20176107 PMID:20185557 PMID:20220442 PMID:20227526 PMID:20301791 PMID:20385918 PMID:20400524 PMID:20434700 PMID:20438629 PMID:20513108 PMID:20513922 PMID:20576279 PMID:20601675 PMID:20691285 PMID:20701905 PMID:20803511 PMID:20818383 PMID:20837861 PMID:20837862 PMID:20843780 PMID:20883824 PMID:20981092 PMID:21038416 PMID:21138766 PMID:21228000 PMID:21228398 PMID:21235791 PMID:21236670 PMID:21259344 PMID:21276947 PMID:21282586 PMID:21301859 PMID:21305355 PMID:21357833 PMID:21447491 PMID:21455106 PMID:21484424 PMID:21515089 PMID:21550804 PMID:21647632 PMID:21654874 PMID:21670405 PMID:21686371 PMID:21696159 PMID:21704543 PMID:21824913 PMID:21856450 PMID:21880868 PMID:21953457 PMID:21956653 PMID:21993618 PMID:22000311 PMID:22006280 PMID:22084276 PMID:22114710 PMID:22166854 PMID:22189570 PMID:22215559 PMID:22237560 PMID:22277967 PMID:22334187 PMID:22342071 PMID:22357363 PMID:22377773 PMID:22470557 PMID:22494076 PMID:22537151 PMID:22552686 PMID:22616202 PMID:22647225 PMID:22711370 PMID:22727047 PMID:22778364 PMID:22805437 PMID:22863191 PMID:22931735 PMID:22933815 PMID:22980518 PMID:22987704 PMID:22995991 PMID:23066759 PMID:23077218 PMID:23084792 PMID:23208208 PMID:23212759 PMID:23248042 PMID:23250882 PMID:23251356 PMID:23299917 PMID:23324391 PMID:23419467 PMID:23426270 PMID:23430834 PMID:23430898 PMID:23446635 PMID:23446645 PMID:23448099 PMID:23524600 PMID:23545419 PMID:23596069 PMID:23665194 PMID:23719791 PMID:23783014 PMID:23804100 PMID:23808377 PMID:23811324 PMID:23830586 PMID:23836942 PMID:23873972 PMID:23921535 PMID:24033266 PMID:24086434 PMID:24091540 PMID:24099403 PMID:24122062 PMID:24194468 PMID:24259288 PMID:24265579 PMID:24266892 PMID:24272679 PMID:24288107 PMID:24331360 PMID:24398692 PMID:24508722 PMID:24642831 PMID:24725338 PMID:24841123 PMID:25025039 PMID:25065347 PMID:25118206 PMID:25129007 PMID:25193669 PMID:25203713 PMID:25281868 PMID:25286830 PMID:25340760 PMID:25356970 PMID:25412673 PMID:25429852 PMID:25462018 PMID:25466440 PMID:25488682 PMID:25497598 PMID:25525159 PMID:25585994 PMID:25638290 PMID:25660390 PMID:25713120 PMID:25724872 PMID:25741868 PMID:25741916 PMID:25742477 PMID:25771874 PMID:25850945 PMID:25852747 PMID:25914719 PMID:25940035 PMID:26050231 PMID:26077851 PMID:26095671 PMID:26104464 PMID:26132555 PMID:26169155 PMID:26224072 PMID:26337858 PMID:26357557 PMID:26467025 PMID:26468652 PMID:26554610 PMID:26557169 PMID:26607151 PMID:26640698 PMID:26735972 PMID:26742794 PMID:26755490 PMID:26942291 PMID:26942292 PMID:26968897 PMID:27016405 PMID:27101133 PMID:27111573 PMID:27119776 PMID:27185166 PMID:27271921 PMID:27290639 PMID:27345795 PMID:27349602 PMID:27381400 PMID:27422324 PMID:27450679 PMID:27475922 PMID:27527004 PMID:27538604 PMID:27538665 PMID:27822509 PMID:27826120 PMID:27838477 PMID:27843123 PMID:27917773 PMID:27987238 PMID:28074849 PMID:28128857 PMID:28130605 PMID:28154168 PMID:28206745 PMID:28337550 PMID:28430993 PMID:28444220 PMID:28471437 PMID:28480171 PMID:28492532 PMID:28634151 PMID:28756246 PMID:28771251 PMID:28776642 PMID:28812649 PMID:28815208 PMID:28837072 PMID:28865037 PMID:28901595 PMID:28958595 PMID:29029963 PMID:29190809 PMID:29214156 PMID:29272804 PMID:29278894 PMID:29302508 PMID:29341116 PMID:29358615 PMID:29423831 PMID:29431110 PMID:29474836 PMID:29482223 PMID:29574624 PMID:29588995 PMID:29644085 PMID:29655203 PMID:29712893 PMID:29913018 PMID:29915382 PMID:29920680 PMID:29950568 PMID:29992832 PMID:29997391 PMID:30009132 PMID:30021052 PMID:30167885 PMID:30255931 PMID:30290626 PMID:30306720 PMID:30369941 PMID:30373890 PMID:30385167 PMID:30393377 PMID:30404819 PMID:30423451 PMID:30451971 PMID:30487145 PMID:30552426 PMID:30609409 PMID:30634555 PMID:30637288 PMID:30678510 PMID:30755392 PMID:30818899 PMID:30831263 PMID:30838265 PMID:30843307 PMID:30860128 PMID:30936349 PMID:30941926 PMID:30951992 PMID:31075681 PMID:31085725 PMID:31130284 PMID:31147703 PMID:31164858 PMID:31209396 PMID:31359948 PMID:31425757 PMID:31475037 PMID:31521625 PMID:31571979 PMID:31589614 PMID:31613174 PMID:31645654 PMID:31655921 PMID:31658717 PMID:31665838 PMID:31669236 PMID:31694722 PMID:31731261 PMID:31762033 PMID:31980526 PMID:31996268 PMID:32005694 PMID:32019516 PMID:32042919 PMID:32161153 PMID:32165824 PMID:32234506 PMID:32305867 PMID:32347949 PMID:32348839 PMID:32364361 PMID:32382377 PMID:32391929 PMID:32445240 PMID:32502631 PMID:32504279 PMID:32531456 PMID:32567010 PMID:32600829 PMID:32613234 PMID:32668698 PMID:32703289 PMID:32964447 PMID:33046616 PMID:33233646 PMID:33258288 PMID:33278787 PMID:33396418 PMID:33434755 PMID:33469851 PMID:33473333 PMID:33486010 PMID:33513296 PMID:33579567 PMID:33600046 PMID:33671400 PMID:33683010 PMID:33726816 PMID:33791913 PMID:33956154 PMID:34008892 PMID:34052969 PMID:34062649 PMID:34189666 PMID:34194468 PMID:34426522 PMID:34670123 PMID:34690748 PMID:34777884 PMID:34782754 PMID:34927673 PMID:35101151 PMID:35114397 PMID:35186329 PMID:35289132 PMID:35307828 PMID:35350396 PMID:35478072 PMID:35488641 PMID:35598585 PMID:35641312 PMID:35699875 PMID:35760101 PMID:35799515 PMID:35811324 PMID:35861376 PMID:36065636 PMID:36325100 PMID:36332611 PMID:36403551 PMID:36689859 PMID:36703223 PMID:36987741 PMID:37091313 PMID:37184518 PMID:37189790 PMID:38294884 More...
RGD:15039298
NCBI chr 7:54,889,150...54,907,167
Ensembl chr 7:54,889,157...54,906,844
G
POLRMT
RNA polymerase mitochondrial
ISO
ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy
ClinVar
PMID:25741868
NCBI chr 2:77,694,271...77,708,099
Ensembl chr 2:77,694,266...77,708,096
G
RLBP1
retinaldehyde binding protein 1
ISO
ClinVar Annotator: match by term: Progressive sclerosing poliodystrophy
ClinVar
PMID:2392416 PMID:11301032 PMID:21447491 PMID:25429852 PMID:28492532
NCBI chr 7:54,783,965...54,800,008
Ensembl chr 7:54,776,113...54,889,014
G
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
ISO
protein:increased expression:serum (human)
RGD
PMID:21290180
RGD:25671452
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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ITGB3
integrin subunit beta 3
ISO
DNA:missense mutation: :p.L33P (human)
RGD
PMID:18685811
RGD:10755472
NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292
G
MTHFR
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)
RGD
PMID:18685811
RGD:10755472
NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
G
SERPINE1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:
RGD
PMID:18685811
RGD:10755472
NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
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ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
ISO
associated with Polycystic Kidney, Autosomal Recessive;mRNA:increased expression:liver
RGD
PMID:20400910
RGD:2325215
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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IL28B
interleukin 28B (interferon, lambda 3)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28394349
NCBI chr 6:47,951,925...47,953,282
Ensembl chr 6:47,951,595...47,953,467
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PKHD1
PKHD1 ciliary IPT domain containing fibrocystin/polyductin
ISO
DNA:mutations:cds:c.7994T>C, p.(Leu2665Pro),c.8518C>T, p.(Arg2840Cys)(human)
RGD
PMID:30507656 PMID:30600684
RGD:14700919 RGD:14700992
NCBI chr 7:45,447,354...45,925,141
Ensembl chr 7:45,450,950...45,925,149
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CTLA4
cytotoxic T-lymphocyte associated protein 4
susceptibility
ISO
DNA:SNP: :-318C>T(human)
RGD
PMID:18049163
RGD:14398738
NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103
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KRT18
keratin 18
ISO
ClinVar Annotator: match by term: Cirrhosis, cryptogenic
ClinVar
PMID:9011570 PMID:12724528
NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429
G
KRT8
keratin 8
ISO
ClinVar Annotator: match by term: Cirrhosis, cryptogenic
ClinVar
PMID:9011570 PMID:11372009 PMID:12724528 PMID:15235035 PMID:25741868 PMID:28492532 PMID:33116287 More...
NCBI chr 5:18,172,423...18,180,277
Ensembl chr 5:18,167,553...18,180,404
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A2M
alpha-2-macroglobulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,440,810...62,483,678
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AADAT
aminoadipate aminotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:19,768,816...19,792,254
Ensembl chr14:19,768,776...19,792,256
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ABAT
4-aminobutyrate aminotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:33,913,068...33,960,804
Ensembl chr 3:33,908,970...34,015,474
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ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16182555 PMID:17072980
NCBI chr 9:93,049,955...93,146,469
G
ABCC2
ATP binding cassette subfamily C member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898
G
ABCC5
ATP binding cassette subfamily C member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:121,868,614...121,957,901
Ensembl chr13:121,869,600...121,926,071
G
ABCG1
ATP binding cassette subfamily G member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:205,561,897...205,628,428
Ensembl chr13:205,561,951...205,628,425
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ABCG5
ATP binding cassette subfamily G member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:96,616,304...96,656,893
Ensembl chr 3:96,616,246...96,656,889
G
ABCG8
ATP binding cassette subfamily G member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:96,596,975...96,616,224
Ensembl chr 3:96,596,531...96,616,229
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ABLIM3
actin binding LIM protein family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:150,260,185...150,423,214
Ensembl chr 2:150,260,196...150,423,212
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ACAT1
acetyl-CoA acetyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:36,525,266...36,545,634
Ensembl chr 9:36,525,261...36,545,633
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ACBD4
acyl-CoA binding domain containing 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:18,271,835...18,281,639
Ensembl chr12:18,272,797...18,281,595
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ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
severity
ISO
protein:increased activity:plasma (human) mRNA: increased expression:liver (rat) mRNA:increased expression:liver (rat)
RGD
PMID:8445218 PMID:19424597 PMID:23663763 PMID:24035938
RGD:21408579 RGD:25671449 RGD:25671457 RGD:25671458
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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ACE2
angiotensin converting enzyme 2
ISO
protein:increased expression:liver mRNA, protein:increased expression, increased activity:liver (rat)
RGD
PMID:16166274 PMID:19793108
RGD:2316776 RGD:40818265
NCBI chr X:12,099,849...12,152,204
Ensembl chr X:12,093,242...12,151,286
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ACHE
acetylcholinesterase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16496349
NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605
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ACKR3
atypical chemokine receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:136,370,457...136,382,559
Ensembl chr15:136,370,530...136,382,553
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ACOT9
acyl-CoA thioesterase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:19,835,674...19,864,570
Ensembl chr X:19,834,614...19,864,660
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ACOX2
acyl-CoA oxidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:40,220,952...40,255,967
Ensembl chr13:40,223,010...40,255,967
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ACP5
acid phosphatase 5, tartrate resistant
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:70,206,159...70,209,855
Ensembl chr 2:70,206,162...70,208,229
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ACSL1
acyl-CoA synthetase long chain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:45,866,858...45,936,327
Ensembl chr15:45,866,857...45,963,729
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ACTA2
actin alpha 2, smooth muscle
ISO
CTD Direct Evidence: marker/mechanism associated with Schistosomiasis Japonica; mRNA:increased expression:liver (rat)
CTD RGD
PMID:26435214 PMID:26739621 PMID:29323718
RGD:38599216
NCBI chr14:100,868,145...100,886,732
Ensembl chr14:100,867,733...100,886,713
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ACTN1
actinin alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:92,550,132...92,644,842
Ensembl chr 7:92,550,007...92,644,842
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ACVR2A
activin A receptor type 2A
ISO
mRNA:decreased expression:liver
RGD
PMID:12706302
RGD:2325237
NCBI chr15:4,177,333...4,259,056
Ensembl chr15:4,173,805...4,259,706
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ADA
adenosine deaminase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245
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ADAM17
ADAM metallopeptidase domain 17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:126,795,513...126,853,995
Ensembl chr 3:126,795,426...126,853,995
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ADD3
adducin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:120,451,421...120,583,725
Ensembl chr14:120,451,575...120,583,722
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ADGRE1
adhesion G protein-coupled receptor E1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:72,217,036...72,305,925
G
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 8:121,225,485...121,259,262 NCBI chr X:98,582,002...98,583,002
Ensembl chr 8:121,225,656...121,261,746
G
ADHFE1
alcohol dehydrogenase iron containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:68,251,970...68,285,436
Ensembl chr 4:68,250,646...68,285,405
G
ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:14724832
NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
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ADIPOR2
adiponectin receptor 2
severity
ISO
RGD
PMID:29237572
RGD:24922203
NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
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ADM
adrenomedullin
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:plasma
CTD RGD
PMID:15370692 PMID:16610064 PMID:16713642
RGD:1625319
NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
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ADORA2A
adenosine A2a receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16783407
NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850
G
ADORA3
adenosine A3 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:108,854,300...108,857,769
Ensembl chr 4:108,854,357...108,873,925
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ADRA1B
adrenoceptor alpha 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:63,550,123...64,010,838
Ensembl chr16:63,550,130...63,603,034
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ADRB1
adrenoceptor beta 1
ISO
mRNA, protein:increased expression:liver
RGD
PMID:19785950
RGD:5129118
NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,330...124,401,739
G
ADRB2
adrenoceptor beta 2
ISO
mRNA, protein:increased expression:liver
RGD
PMID:19785950
RGD:5129118
NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,033,579...150,040,731
G
ADRB3
adrenoceptor beta 3
ISO
mRNA, protein:increased expression:liver
RGD
PMID:19785950
RGD:5129118
NCBI chr15:48,468,803...48,478,370
Ensembl chr15:48,475,144...48,479,562
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AEN
apoptosis enhancing nuclease
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:191,200,625...191,211,884
Ensembl chr 1:191,200,632...191,219,961
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AFM
afamin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:69,706,823...69,728,269
Ensembl chr 8:69,706,896...69,728,255
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AFP
alpha fetoprotein
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17072980 PMID:30346985
RGD:151665755
NCBI chr 8:69,677,690...69,698,864
Ensembl chr 8:69,677,690...69,698,864
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AGFG1
ArfGAP with FG repeats 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:128,898,806...128,980,782
Ensembl chr15:128,898,705...128,975,510
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AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:118,186,031...118,269,106
Ensembl chr 4:118,177,377...118,269,101
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AGT
angiotensinogen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12667390
NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
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AGTR1
angiotensin II receptor type 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12890498 PMID:24619965 PMID:25380136
RGD:10403061
NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105
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AHNAK
AHNAK nucleoprotein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:9,186,984...9,216,450
Ensembl chr 2:9,183,862...9,287,455
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AIDA
axin interactor, dorsalization associated
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:11,430,758...11,466,849
Ensembl chr10:11,428,399...11,466,643
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AIF1
allograft inflammatory factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,728,726...23,731,675
G
AKR1B1
aldo-keto reductase family 1 member B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:14,593,516...14,752,316
Ensembl chr18:14,684,036...14,752,310
G
AKR1C1
aldo-keto reductase family 1, member C1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248
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AKT1
AKT serine/threonine kinase 1
ISO
protein:increased phosphorylation:liver
RGD
PMID:31671832
RGD:407987423
G
AKTIP
AKT interacting protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:31,706,253...31,757,878
Ensembl chr 6:31,747,606...31,758,279
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ALB
albumin
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16642209 PMID:17963606 PMID:21163135 PMID:30346985
RGD:151665755
NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
G
ALDH1A1
aldehyde dehydrogenase 1 family member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 1:226,163,347...226,217,342
Ensembl chr 1:226,161,299...226,217,308
G
ALDH1B1
aldehyde dehydrogenase 1 family member B1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15650968 PMID:25380136
NCBI chr 1:239,109,814...239,114,736
Ensembl chr 1:239,109,809...239,114,730
G
ALDH1L1
aldehyde dehydrogenase 1 family member L1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15650968
NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,653...53,794,706
G
ALDH1L2
aldehyde dehydrogenase 1 family member L2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:79,492,672...79,558,702
Ensembl chr 5:79,492,732...79,558,701
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ALDH2
aldehyde dehydrogenase 2 family member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15650968
NCBI chr14:39,902,317...39,933,113
Ensembl chr14:39,896,565...39,933,124
G
AMACR
alpha-methylacyl-CoA racemase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr16:20,005,741...20,023,339
Ensembl chr16:19,956,366...20,023,289
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ANGPT1
angiopoietin 1
disease_progression
ISO
protein:increased expression:liver
RGD
PMID:17935226
RGD:1643338
NCBI chr 4:29,925,203...30,233,434
Ensembl chr 4:29,933,135...30,233,960
G
ANGPT2
angiopoietin 2
ISO
mRNA, protein:increased expression:multiple organs (rat)
RGD
PMID:18978178
RGD:2314174
NCBI chr15:37,544,177...37,600,925
Ensembl chr15:37,544,707...37,599,041
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ANGPTL3
angiopoietin like 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:149,836,417...149,845,854
Ensembl chr 6:149,832,542...149,845,831
G
ANO6
anoctamin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:76,112,428...76,337,073
Ensembl chr 5:76,113,212...76,356,544
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ANP32A
acidic nuclear phosphoprotein 32 family member A
treatment
ISO
RGD
PMID:19054144
RGD:10401133
NCBI chr 1:166,664,251...166,703,814
G
ANXA1
annexin A1
ISO
mRNA:increased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8755646 PMID:25380136
RGD:2306954
NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279
G
ANXA2
annexin A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059
G
ANXA3
annexin A3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:73,970,314...73,993,039
G
ANXA4
annexin A4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:72,623,311...72,654,591
Ensembl chr 3:72,622,358...72,694,212
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ANXA5
annexin A5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
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AP1S2
adaptor related protein complex 1 subunit sigma 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:12,367,785...12,397,672
Ensembl chr X:12,367,795...12,397,677
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AP3S1
adaptor related protein complex 3 subunit sigma 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:119,965,539...120,039,948
Ensembl chr 2:119,965,539...120,039,947
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APAF1
apoptotic peptidase activating factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364
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APBB1IP
amyloid beta precursor protein binding family B member 1 interacting protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:49,125,074...49,242,864
Ensembl chr10:49,124,543...49,189,308
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APMAP
adipocyte plasma membrane associated protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:30,768,485...30,795,002
Ensembl chr17:30,768,488...30,795,755
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APOA1
apolipoprotein A1
ISO
RGD
PMID:2123716
RGD:1599161
NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
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APOA4
apolipoprotein A4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:44,201,587...44,204,072
Ensembl chr 9:44,201,508...44,204,206
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APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:62,811,819...62,820,532
Ensembl chr 5:62,810,879...62,820,173
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APP
amyloid beta precursor protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056
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APPL1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:39,089,157...39,124,969
Ensembl chr13:39,089,077...39,129,781
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AQP7
aquaporin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr10:33,098,746...33,130,245
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ARG1
arginase 1
ISO
mRNA, protein:decreased expression:liver (rat)
RGD
PMID:11931836
RGD:1626298
NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,046...32,028,988
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ARG2
arginase 2
ISO
mRNA, protein:increased expression:liver
RGD
PMID:11931836
RGD:1626298
NCBI chr 7:91,343,987...91,385,911
Ensembl chr 7:91,343,988...91,385,909
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ARHGAP30
Rho GTPase activating protein 30
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:89,375,486...89,394,190
Ensembl chr 4:89,375,526...89,394,244
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ARHGAP9
Rho GTPase activating protein 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:22,747,346...22,762,179
Ensembl chr 5:22,747,339...22,762,049
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ARHGDIB
Rho GDP dissociation inhibitor beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:57,576,754...57,598,395
Ensembl chr 5:57,576,776...57,598,869
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ARL11
ARF like GTPase 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:18,097,723...18,100,425
Ensembl chr11:18,095,974...18,099,819
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ARL8A
ADP ribosylation factor like GTPase 8A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:24,314,929...24,324,225
Ensembl chr10:24,314,932...24,324,228
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ARMCX1
armadillo repeat containing X-linked 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:83,132,775...83,136,924
Ensembl chr X:83,132,792...83,136,917
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ARPC1B
actin related protein 2/3 complex subunit 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:6,329,737...6,342,641
Ensembl chr 3:6,220,939...6,342,637
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ARRB2
arrestin beta 2
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:aorta
CTD RGD
PMID:17256744 PMID:25380136
RGD:1625784
NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342
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ASAH1
N-acylsphingosine amidohydrolase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:5,712,048...5,749,811
Ensembl chr17:5,712,058...5,758,821
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ASNS
asparagine synthetase (glutamine-hydrolyzing)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:77,318,341...77,336,290
Ensembl chr 9:77,318,213...77,343,035
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ASPN
asporin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:42,165,553...42,192,902
Ensembl chr 3:42,165,561...42,192,813
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ASS1
argininosuccinate synthase 1
ISO
mRNA:decreased expression:liver (rat)
RGD
PMID:19914391
RGD:4140452
NCBI chr 1:270,531,434...270,586,364
Ensembl chr 1:270,531,589...270,586,364
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ATF3
activating transcription factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506
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ATP10D
ATPase phospholipid transporting 10D (putative)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:37,407,677...37,531,707
Ensembl chr 8:37,407,711...37,530,373
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ATP6V1D
ATPase H+ transporting V1 subunit D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:91,065,998...91,084,908
Ensembl chr 7:91,064,396...91,084,913
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ATRN
attractin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:32,054,240...32,239,576
Ensembl chr17:32,054,249...32,239,519
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AXL
AXL receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:49,245,802...49,277,917
Ensembl chr 6:49,245,673...49,277,914
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B2M
beta-2-microglobulin
ISO
protein:increased expression:urine
RGD
PMID:18777138
RGD:6482712
NCBI chr 1:126,837,721...126,844,043
Ensembl chr 1:126,835,143...126,981,582
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B4GALT5
beta-1,4-galactosyltransferase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:51,257,273...51,334,566
Ensembl chr17:51,259,813...51,334,020
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B9D1
B9 domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:60,162,656...60,171,586
Ensembl chr12:60,162,713...60,171,961
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BAK1
BCL2 antagonist/killer 1
ISO
mRNA:increased expression:liver
RGD
PMID:11232245
RGD:2315709
NCBI chr 7:29,808,849...29,815,345
Ensembl chr 7:29,808,849...29,815,318
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BBOX1
gamma-butyrobetaine hydroxylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:33,227,965...33,296,013
Ensembl chr 2:33,227,974...33,296,559
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BCL2
BCL2 apoptosis regulator
treatment
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:17938867 PMID:24218972
RGD:10054116 RGD:2293129
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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BCR
BCR activator of RhoGEF and GTPase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:49,208,662...49,322,109
Ensembl chr14:49,208,762...49,322,103
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BDH1
3-hydroxybutyrate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr13:132,602,372...132,647,271
Ensembl chr13:132,605,489...132,645,937
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BGN
biglycan
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:124,282,048...124,295,450
Ensembl chr X:124,275,305...124,295,445
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BICD2
BICD cargo adaptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:42,393,270...42,456,821
Ensembl chr 3:42,393,277...42,456,782
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BIRC3
baculoviral IAP repeat containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,002,734...33,020,242
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BIRC5
baculoviral IAP repeat containing 5
ISO
RGD
PMID:17938867
RGD:2293129
NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215
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BLOC1S2
biogenesis of lysosomal organelles complex 1 subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:111,391,083...111,397,609
Ensembl chr14:111,391,089...111,397,639
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BLVRA
biliverdin reductase A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:51,131,576...51,185,493
Ensembl chr18:51,131,584...51,185,435
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BMF
Bcl2 modifying factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:131,178,021...131,199,668
Ensembl chr 1:131,178,315...131,200,393
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BMP4
bone morphogenetic protein 4
ISO
mRNA, protein:increased expression:liver
RGD
PMID:16447265
RGD:1643229
NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637
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BMP7
bone morphogenetic protein 7
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17127702
NCBI chr17:57,567,770...57,676,516
Ensembl chr17:57,584,956...57,675,986
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C13H3orf70
chromosome 13 C3orf70 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:122,958,339...123,058,988
Ensembl chr13:122,958,347...123,058,655
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C1QA
complement C1q A chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:80,586,259...80,589,213
Ensembl chr 6:80,586,280...80,589,204
G
C1QB
complement C1q B chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:80,601,680...80,606,076
Ensembl chr 6:80,601,665...80,607,471
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C1QC
complement C1q C chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,473...80,597,452
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C5AR1
complement C5a receptor 1
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15995705 PMID:25380136
RGD:1600592
NCBI chr 6:53,097,162...53,111,563
Ensembl chr 6:53,097,142...53,111,565
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C6H1orf210
chromosome 6 C1orf210 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:167,959,845...167,963,610
Ensembl chr 6:167,960,095...167,963,583
G
C7
complement C7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980
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C8G
complement C8 gamma chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
C9H11orf54
chromosome 9 C11orf54 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:26,167,341...26,187,627
Ensembl chr 9:26,170,413...26,187,619
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C9H1orf21
chromosome 9 C1orf21 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:125,613,082...125,846,002
Ensembl chr 9:125,613,193...125,844,228
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CA3
carbonic anhydrase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 4:51,227,485...51,237,861
Ensembl chr 4:51,227,485...51,237,844
G
CA5A
carbonic anhydrase 5A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:1,495,615...1,539,390
Ensembl chr 6:1,506,042...1,538,777
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CAMK2D
calcium/calmodulin dependent protein kinase II delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:108,916,019...109,221,317
Ensembl chr 8:108,915,572...109,222,905
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CAPG
capping actin protein, gelsolin like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:59,335,483...59,366,855
Ensembl chr 3:59,339,966...59,366,846
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CASP1
caspase 1, apoptosis-related cysteine peptidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
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CASP7
caspase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:124,017,776...124,050,369
Ensembl chr14:124,019,164...124,050,365
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CAV1
caveolin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
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CCDC126
coiled-coil domain containing 126
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:92,372,070...92,419,241
Ensembl chr 9:92,372,072...92,419,236
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CCL2
chemokine (C-C motif) ligand 2
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15492853 PMID:19144177 PMID:28437891
RGD:14995945 RGD:2307001 RGD:8549576
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
G
CCL5
C-C motif chemokine ligand 5
treatment disease_progression severity
ISO
mRNA,protein:increased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20978355 PMID:22574195 PMID:25380136 PMID:25617348
RGD:14995328 RGD:14995329 RGD:14995337
NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
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CCN2
cellular communication network factor 2
ISO
mRNA:increased expression:liver (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19856102 PMID:25380136
RGD:2314367
NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691
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CCN4
cellular communication network factor 4
ISO
RGD
PMID:24600972
RGD:10003105
NCBI chr 4:8,078,163...8,110,906
Ensembl chr 4:8,079,755...8,110,700
G
CCNA2
cyclin A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:102,260,346...102,266,274
Ensembl chr 8:102,260,215...102,266,309
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CCNB2
cyclin B2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:112,907,047...112,942,218
Ensembl chr 1:112,907,047...112,942,235
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CCNG1
cyclin G1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:60,349,255...60,356,737
Ensembl chr16:60,349,258...60,356,738
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CCR5
C-C motif chemokine receptor 5
treatment
ISO
mRNA,protein:increased expression:liver
RGD
PMID:19603542
RGD:14401743
NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895
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CD163
CD163 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498
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CD200R1
CD200 receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:146,953,135...146,994,325
Ensembl chr13:146,953,149...146,995,323
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CD276
CD276 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:59,703,283...59,733,910
Ensembl chr 7:59,703,289...59,733,777
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CD36
CD36 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105
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CD38
CD38 molecule
ISO
mRNA, protein:increased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16343077 PMID:25380136
RGD:2307239
NCBI chr 8:11,083,682...11,130,783
Ensembl chr 8:11,083,682...11,130,756
G
CD48
CD48 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:89,828,923...89,844,471
Ensembl chr 4:89,828,923...89,844,484
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CD53
CD53 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:109,306,552...109,335,876
Ensembl chr 4:109,306,555...109,335,802
G
CD5L
CD5 molecule like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:92,394,535...92,412,146
G
CD63
CD63 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:21,172,275...21,176,225
Ensembl chr 5:21,172,283...21,176,232
G
CD68
CD68 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:52,874,754...52,877,256
Ensembl chr12:52,874,785...52,877,695
G
CD7
CD7 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:740,345...744,876
G
CD74
CD74 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:151,402,210...151,409,924
Ensembl chr 2:151,402,211...151,409,833
G
CD83
CD83 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:10,346,122...10,385,968
Ensembl chr 7:10,359,211...10,385,961
G
CD86
CD86 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310
G
CDC42SE1
CDC42 small effector 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:98,171,937...98,180,577
Ensembl chr 4:98,164,024...98,180,576
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CDH1
cadherin 1
ISO
associated with Schistosomiasis Japonica; mRNA:decreased expression:liver (rat)
RGD
PMID:29323718
RGD:38599216
NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986
G
CDH5
cadherin 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177
G
CDK1
cyclin dependent kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197
G
CDK2
cyclin dependent kinase 2
ISO
RGD
PMID:16534847
RGD:2289284
NCBI chr 5:21,365,723...21,372,170
Ensembl chr 5:21,365,764...21,372,168
G
CDK4
cyclin dependent kinase 4
ISO
RGD
PMID:16534847
RGD:2289284
NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061
G
CDKN1A
cyclin dependent kinase inhibitor 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761
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CDKN2AIPNL
CDKN2A interacting protein N-terminal like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:136,678,015...136,685,901
Ensembl chr 2:136,677,034...136,685,955
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CDKN3
cyclin dependent kinase inhibitor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:183,792,606...183,809,178
Ensembl chr 1:183,792,688...183,809,174
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CDO1
cysteine dioxygenase type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 2:119,927,768...119,940,690
Ensembl chr 2:119,927,772...119,940,665
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CEBPD
CCAAT enhancer binding protein delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:79,872,863...79,874,481
Ensembl chr 4:79,872,939...79,874,477
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CELA1
chymotrypsin like elastase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
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CELF2
CUGBP Elav-like family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:60,504,925...60,867,631
Ensembl chr10:60,506,504...61,084,960
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CEMIP2
cell migration inducing hyaluronidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:224,960,875...225,042,378
Ensembl chr 1:224,960,875...225,042,308
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CERK
ceramide kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:2,818,738...2,870,200
Ensembl chr 5:2,818,784...2,870,195
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CES3
carboxylesterase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 6:27,627,712...27,637,827
Ensembl chr 6:27,627,742...27,638,760
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CFD
complement factor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:77,509,792...77,511,988
Ensembl chr 2:77,509,795...77,511,974
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CFP
complement factor properdin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:42,145,754...42,152,879
Ensembl chr X:42,143,697...42,152,868
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CHSY1
chondroitin sulfate synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:139,730,703...139,804,458
Ensembl chr 1:139,730,721...139,804,657
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CIDEA
cell death inducing DFFA like effector a
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:97,253,074...97,268,355
Ensembl chr 6:97,253,074...97,267,405
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CKLF
chemokine like factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:27,258,392...27,267,701
Ensembl chr 6:27,258,551...27,267,753
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CLEC4F
C-type lectin domain family 4 member F
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:71,683,898...71,696,357
Ensembl chr 3:71,677,918...71,696,346
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CLIC1
chloride intracellular channel 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:23,842,829...23,851,162
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CLIC2
chloride intracellular channel 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:125,546,451...125,560,059
Ensembl chr X:125,546,467...125,570,523
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CLP1
cleavage factor polyribonucleotide kinase subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:13,282,157...13,285,208
Ensembl chr 2:13,282,164...13,285,162
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CMTM3
CKLF like MARVEL transmembrane domain containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:27,308,146...27,320,449
Ensembl chr 6:27,308,141...27,317,308
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CNDP1
carnosine dipeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:149,523,983...149,564,728
Ensembl chr 1:149,521,510...149,562,623
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CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:20,758,081...20,765,655
Ensembl chr12:20,758,083...20,765,553
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CNPY4
canopy FGF signaling regulator 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:8,026,997...8,031,685
Ensembl chr 3:8,027,054...8,031,927
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CNR1
cannabinoid receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17043671
NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602
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COL12A1
collagen type XII alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:90,744,409...90,875,127
Ensembl chr 1:90,744,612...90,875,118
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COL1A1
collagen type I alpha 1 chain
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:liver mRNA, protein:increased expression:liver (rat)
CTD RGD
PMID:16009107 PMID:20818932 PMID:22706148 PMID:23958495 PMID:25380136 PMID:26435214 PMID:26739621 PMID:30346985 More...
RGD:151665755 RGD:1601595 RGD:5688339 RGD:8552710 RGD:8552768
NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,004
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COL1A2
collagen type I alpha 2 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:7512265 PMID:25380136
RGD:7257544
NCBI chr 9:74,174,484...74,210,407
Ensembl chr 9:74,173,931...74,210,397
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COL3A1
collagen type III alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11788567 PMID:25380136
NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,526,603...93,596,363
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COL4A1
collagen type IV alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:76,858,332...76,997,409
Ensembl chr11:76,858,356...76,997,322
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COL4A2
collagen type IV alpha 2 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,614
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COL5A1
collagen type V alpha 1 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:273,934,219...274,083,264
Ensembl chr 1:273,971,971...274,085,111
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COL5A2
collagen type V alpha 2 chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:93,611,856...93,981,131
Ensembl chr15:93,611,856...93,800,191
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COL6A2
collagen type VI alpha 2 chain
ISO
CTD Direct Evidence: marker/mechanism Protein:increased expression:liver
CTD RGD
PMID:7791542 PMID:25380136
RGD:1600938
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COLEC12
collectin subfamily member 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:105,808,157...106,000,197
Ensembl chr 6:105,808,221...106,007,730
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COQ10A
coenzyme Q10A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:21,665,252...21,670,323
Ensembl chr 5:21,665,252...21,669,045
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COTL1
coactosin like F-actin binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:4,099,341...4,146,281
Ensembl chr 6:4,099,414...4,147,469
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CPQ
carboxypeptidase Q
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:39,492,663...39,855,959
Ensembl chr 4:39,480,676...39,967,629
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CPS1
carbamoyl-phosphate synthase 1
ISO
CTD Direct Evidence: marker/mechanism mRNA:decreased expression:liver
CTD RGD
PMID:15650968 PMID:17539997
RGD:2303515
NCBI chr15:113,210,038...113,339,086
Ensembl chr15:113,150,157...113,339,078
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CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:89,257,603...89,480,414
Ensembl chr 5:89,267,944...89,479,712
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CREB1
cAMP responsive element binding protein 1
ISO
associated with Chemical and Drug Induced Liver Injury
RGD
PMID:27279449
RGD:401960093
NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
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CROT
carnitine O-octanoyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:93,263,606...93,308,150
Ensembl chr 9:93,258,619...93,308,151
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CRP
C-reactive protein, pentraxin-related
ISO
protein:decreased expression:serum:
RGD
PMID:21806828
RGD:9491781
NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218
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CRTAP
cartilage associated protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:18,994,371...19,040,297
Ensembl chr13:18,995,234...19,035,720
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CRY1
cryptochrome circadian regulator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:13,275,265...13,429,566
Ensembl chr 5:13,275,545...13,364,593
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CRYAB
crystallin alpha B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,506...39,643,530
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CSAD
cysteine sulfinic acid decarboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 5:18,379,340...18,410,446
Ensembl chr 5:18,379,288...18,410,646
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CSF1R
colony stimulating factor 1 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633
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CSF3
colony stimulating factor 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15661404
NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753
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CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:12,145,141...12,498,777
Ensembl chr17:12,428,893...12,498,585
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CTSS
cathepsin S
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:98,415,273...98,442,952
Ensembl chr 4:98,417,883...98,442,950
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CTSZ
cathepsin Z
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:59,141,497...59,149,377
Ensembl chr17:59,138,621...59,149,377
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CTTNBP2NL
CTTNBP2 N-terminal like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:107,957,420...108,012,764
Ensembl chr 4:107,959,571...108,011,611
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CXADR
CXADR Ig-like cell adhesion molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:182,134,416...182,185,977
Ensembl chr13:182,134,566...182,185,950
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CXCL10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
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CXCL12
C-X-C motif chemokine ligand 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:91,516,383...91,543,857
Ensembl chr14:91,516,431...91,552,752
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CXCL13
C-X-C motif chemokine ligand 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:73,071,261...73,077,342
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CXCL16
C-X-C motif chemokine ligand 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:52,145,100...52,150,267
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CXCL9
C-X-C motif chemokine ligand 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271
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CYBA
cytochrome b-245 alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420
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CYGB
cytoglobin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16581302
NCBI chr12:4,977,245...4,988,283
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CYP17A1
cytochrome P450 family 17 subfamily A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
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CYP1A2
cytochrome P450 family 1 subfamily A member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
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CYP26A1
cytochrome P450 family 26 subfamily A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:104,561,394...104,567,099
Ensembl chr14:104,563,195...104,567,095
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642
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CYP3A22
cytochrome P450 family 3 subfamily A member 22
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817
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CYP3A29
cytochrome P450 family 3 subfamily A member 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944
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CYP7A1
cytochrome P450 family 7 subfamily A member 1
treatment
ISO
RGD
PMID:15521018
RGD:15045602
NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,343,123...74,372,621
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CYRIA
CYFIP related Rac1 interactor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:120,968,016...121,069,372
Ensembl chr 3:120,968,060...121,069,240
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CYRIB
CYFIP related Rac1 interactor B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:10,476,137...10,643,395
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CYSTM1
cysteine rich transmembrane module containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:141,945,032...142,010,239
Ensembl chr 2:141,954,092...141,992,368
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DAG1
dystroglycan 1
ISO
mRNA:increased expression:liver
RGD
PMID:12177244
RGD:2314895
NCBI chr13:32,028,019...32,092,450
Ensembl chr13:32,029,522...32,092,450
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DAO
D-amino acid oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633
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DBH
dopamine beta-hydroxylase
ISO
mRNA:decreased expression:superior mesenteric artery (rat)
RGD
PMID:18457899
RGD:5129683
NCBI chr 1:273,204,407...273,225,562
Ensembl chr 1:273,204,175...273,225,552
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DBNDD2
dysbindin domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:47,686,220...47,729,663
Ensembl chr17:47,725,132...47,729,668
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DCXR
dicarbonyl and L-xylulose reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:978,131...980,042
Ensembl chr12:978,139...982,259
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DDC
dopa decarboxylase
ISO
mRNA:decreased expression:superior mesenteric artery (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18457899 PMID:25380136
RGD:5129683
NCBI chr 9:136,496,364...136,571,220
Ensembl chr 9:136,496,365...136,571,212
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DEPDC7
DEP domain containing 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:27,909,282...27,928,859
Ensembl chr 2:27,909,285...27,928,820
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DHRS3
dehydrogenase/reductase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:72,556,234...72,599,233
Ensembl chr 6:72,556,236...72,598,815
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DHRS7
dehydrogenase/reductase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:189,153,579...189,170,745
Ensembl chr 1:189,151,131...189,170,534
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DHTKD1
dehydrogenase E1 and transketolase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:59,820,418...59,875,322
Ensembl chr10:59,820,423...59,875,290
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DIO1
iodothyronine deiodinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 6:158,376,744...158,392,745
Ensembl chr 6:158,375,602...158,392,754
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DIPK2A
divergent protein kinase domain 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:84,634,716...84,656,112
Ensembl chr13:84,634,777...84,657,371
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DOCK10
dedicator of cytokinesis 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:126,435,577...126,711,755
Ensembl chr15:126,435,579...126,711,531
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DOCK7
dedicator of cytokinesis 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:149,745,375...149,971,853
Ensembl chr 6:149,748,036...149,972,168
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DPP7
dipeptidyl peptidase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
DPYS
dihydropyrimidinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:32,791,152...32,879,489
Ensembl chr 4:32,789,460...32,879,489
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DRAM1
DNA damage regulated autophagy modulator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:82,292,578...82,325,580
Ensembl chr 5:82,290,385...82,325,562
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DUS1L
dihydrouridine synthase 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:945,459...951,720
Ensembl chr12:946,048...951,776
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DUSP16
dual specificity phosphatase 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:59,869,902...59,961,839
Ensembl chr 5:59,915,197...59,961,829
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DUSP6
dual specificity phosphatase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:93,303,058...93,307,510
Ensembl chr 5:93,302,975...93,307,504
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DYSF
dysferlin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:71,020,143...71,237,658
Ensembl chr 3:71,020,144...71,246,967
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ECE1
endothelin converting enzyme 1
ISO
protein:increased expression:liver
RGD
PMID:16170464
RGD:7243952
NCBI chr 6:79,408,322...79,465,827
Ensembl chr 6:79,408,326...79,466,152
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ECT2
epithelial cell transforming 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:111,248,215...111,310,746
Ensembl chr13:111,248,131...111,314,828
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EDN1
endothelin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12609069
NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
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EEIG2
EEIG family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:111,391,672...111,467,230
Ensembl chr 4:111,392,338...111,467,300
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EGF
epidermal growth factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046
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EIF4E3
eukaryotic translation initiation factor 4E family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:53,080,200...53,152,335
Ensembl chr13:53,083,645...53,124,240
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ELOVL5
ELOVL fatty acid elongase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:46,860,768...46,932,945
Ensembl chr 7:46,860,770...46,932,926
G
EMB
embigin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:30,121,072...30,170,495
Ensembl chr16:30,120,493...30,287,793
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EMP1
epithelial membrane protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:59,245,317...59,267,466
Ensembl chr 5:59,244,691...59,268,025
G
ENC1
ectodermal-neural cortex 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:83,678,518...83,691,812
Ensembl chr 2:83,678,521...83,691,400
G
ENPEP
glutamyl aminopeptidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
G
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased activity:serum:
CTD RGD
PMID:17072980 PMID:17850827 PMID:20957682
RGD:9685426 RGD:9685427
NCBI chr 4:19,319,815...19,433,492
Ensembl chr 4:19,319,810...19,433,488
G
ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
ISO
RGD
PMID:15651265
RGD:9685530
G
EPB41L2
erythrocyte membrane protein band 4.1 like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:32,418,210...32,630,643
Ensembl chr 1:32,418,217...32,630,638
G
EPCAM
epithelial cell adhesion molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:93,169,800...93,185,221
Ensembl chr 3:93,168,852...93,185,653
G
ERAP1
endoplasmic reticulum aminopeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:103,378,428...103,415,066
Ensembl chr 2:103,378,429...103,408,759
G
ERN1
endoplasmic reticulum to nucleus signaling 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30538632
NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
G
EXTL1
exostosin like glycosyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:83,461,421...83,476,601
Ensembl chr 6:83,462,323...83,476,596
G
EZR
ezrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:8,403,362...8,452,750
Ensembl chr 1:8,403,453...8,452,742
G
F2R
coagulation factor II thrombin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:85,642,794...85,659,133
Ensembl chr 2:85,641,474...85,656,636
G
F5
coagulation factor V
treatment
ISO
RGD
PMID:17431769
RGD:7394781
NCBI chr 4:81,403,273...81,484,908
Ensembl chr 4:81,403,274...81,485,066
G
FABP2
fatty acid binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480
G
FABP7
fatty acid binding protein 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 1:39,872,198...39,876,272
Ensembl chr 1:39,871,537...39,876,397
G
FAHD1
fumarylacetoacetate hydrolase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:121,538,308...121,539,037
Ensembl chr 3:40,141,132...40,141,806
G
FAM167B
family with sequence similarity 167 member B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:88,715,710...88,717,272
Ensembl chr 6:88,715,794...88,717,269
G
FAM43A
family with sequence similarity 43 member A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:131,662,474...131,665,653
Ensembl chr13:131,663,310...131,665,439
G
FAM89A
family with sequence similarity 89 member A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:59,367,745...59,388,793
Ensembl chr14:59,367,739...59,388,749
G
FAS
Fas cell surface death receptor
ISO
mRNA, protein:increased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17105443 PMID:30737368
RGD:2290284
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
G
FAT1
FAT atypical cadherin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:8,466,099...8,580,715
Ensembl chr17:8,457,187...8,580,715
G
FBN1
fibrillin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649
G
FBXO9
F-box protein 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:46,723,579...46,748,132
Ensembl chr 7:46,723,680...46,748,121
G
FCER1G
Fc epsilon receptor Ig
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:89,242,467...89,246,344
Ensembl chr 4:89,242,472...89,246,450
G
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:99,233,632...99,242,531
Ensembl chr 4:99,233,611...99,242,586
G
FCGR3A
Fc fragment of IgG receptor IIIa
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:88,948,357...88,956,513
G
FCN2
ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:274,106,276...274,111,970
Ensembl chr 1:274,103,877...274,111,970
G
FGF2
fibroblast growth factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16116963
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
G
FGFR1
fibroblast growth factor receptor 1
treatment
ISO
RGD
PMID:21543745
RGD:25440477
NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724
G
FGG
fibrinogen gamma chain
ISO
mRNA:increased expression
RGD
PMID:17054587
RGD:1599810
NCBI chr 8:74,553,040...74,562,151
Ensembl chr 8:74,553,105...74,563,688
G
FGL2
fibrinogen like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:102,869,044...102,875,564
Ensembl chr 9:102,868,802...102,875,576
G
FGR
FGR proto-oncogene, Src family tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:84,809,534...84,830,401
Ensembl chr 6:84,809,542...84,830,361
G
FHL1
four and a half LIM domains 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:111,309,989...111,367,900
Ensembl chr X:111,356,011...111,367,903
G
FHL2
four and a half LIM domains 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:49,389,900...49,448,459
Ensembl chr 3:49,363,555...49,467,527
G
FKBP1A
FKBP prolyl isomerase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:33,910,047...33,935,212
G
FLI1
Fli-1 proto-oncogene, ETS transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:55,612,905...55,749,784
Ensembl chr 9:55,612,901...55,749,778
G
FLNA
filamin A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:124,889,934...124,915,000
Ensembl chr X:124,890,162...124,914,992
G
FMNL1
formin like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:18,198,764...18,225,621
Ensembl chr12:18,198,769...18,225,365
G
FMNL2
formin like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:60,054,300...60,384,666
Ensembl chr15:60,053,877...60,384,655
G
FMO1
flavin containing dimethylaniline monoxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
G
FN1
fibronectin 1
treatment
ISO
mRNA:altered expression:liver (rat) mRNA:increased expression:liver:
RGD
PMID:15980055 PMID:19914391
RGD:1625201 RGD:4140452
NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043
G
FOLR2
folate receptor 2 (fetal)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:6,785,308...6,790,466
Ensembl chr 9:6,785,303...6,790,465
G
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
G
FOXA2
forkhead box A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:29,997,397...30,001,704
Ensembl chr17:29,997,401...30,001,707
G
FOXO1
forkhead box O1
ISO
associated with Schistosomiasis Japonica; mRNA:decreased expression:liver (rat)
RGD
PMID:29323718
RGD:38599216
NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473
G
FRY
FRY microtubule binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:8,518,514...8,765,089
Ensembl chr11:8,518,715...8,763,899
G
FSTL1
follistatin like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:139,847,246...139,901,972
Ensembl chr13:139,847,438...139,901,965
G
FTCD
formimidoyltransferase cyclodeaminase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
FXYD2
FXYD domain containing ion transport regulator 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:45,165,314...45,172,440
G
FXYD5
FXYD domain containing ion transport regulator 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:44,682,245...44,696,088
G
FXYD6
FXYD domain containing ion transport regulator 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:45,182,396...45,218,249
G
FYN
FYN proto-oncogene, Src family tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581
G
FZD8
frizzled class receptor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:58,093,980...58,096,790
Ensembl chr10:58,094,689...58,096,769
G
G0S2
G0/G1 switch 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:133,287,065...133,288,066
Ensembl chr 9:133,287,325...133,287,742
G
G6PC1
glucose-6-phosphatase catalytic subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:19,965,885...19,975,783
Ensembl chr12:19,965,330...19,975,857
G
GAB1
GRB2 associated binding protein 1
ISO
protein:increased tyrosine phosphorylation: :
RGD
PMID:25617348
RGD:14995329
NCBI chr 8:84,257,958...84,391,511
Ensembl chr 8:84,257,965...84,391,914
G
GALC
galactosylceramidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:109,894,576...109,961,407
Ensembl chr 7:109,894,578...109,961,413
G
GASK1B
golgi associated kinase 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:47,036,905...47,133,914
Ensembl chr 8:47,036,899...47,098,718
G
GBP2
guanylate binding protein 2, interferon-inducible
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:127,387,222...127,408,729
Ensembl chr 4:127,379,740...127,408,699
G
GC
GC vitamin D binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262
G
GCAT
glycine C-acetyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:10,027,133...10,038,494
Ensembl chr 5:10,027,044...10,038,433
G
GCHFR
GTP cyclohydrolase I feedback regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:130,559,223...130,563,598
Ensembl chr 1:130,554,978...130,559,597
G
GCNT1
glucosaminyl (N-acetyl) transferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:229,429,020...229,602,834
Ensembl chr 1:229,429,066...229,468,268
G
GET1
guided entry of tail-anchored proteins factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:202,962,652...202,978,390
Ensembl chr13:202,962,664...202,979,902
G
GFAP
glial fibrillary acidic protein
ISO
associated with Schistosomiasis Japonica; mRNA:decreased expression:liver (rat)
RGD
PMID:29323718
RGD:38599216
NCBI chr12:18,456,268...18,466,594
Ensembl chr12:18,456,263...18,466,592
G
GFRA1
GDNF family receptor alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:126,273,558...126,499,957
Ensembl chr14:126,277,875...126,499,465
G
GGH
gamma-glutamyl hydrolase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:70,996,730...71,020,513
Ensembl chr 4:70,996,755...71,021,838
G
GGTA1
glycoprotein alpha-galactosyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:261,511,304...261,587,968
G
GHR
growth hormone receptor
ISO
mRNA, protein:decreased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12679928 PMID:17072980 PMID:25380136
RGD:2307378
NCBI chr16:27,126,300...27,422,618
Ensembl chr16:27,126,734...27,421,449
G
GJA1
gap junction protein alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156
G
GJA4
gap junction protein alpha 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:91,045,430...91,048,161
Ensembl chr 6:91,045,394...91,048,162
G
GK
glycerol kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:26,470,422...26,558,892
G
GLIPR1
GLI pathogenesis related 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:38,758,594...38,811,857
Ensembl chr 5:38,766,998...38,815,597
G
GLS
glutaminase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:95,513,414...95,606,029
Ensembl chr15:95,513,446...95,598,311
G
GLS2
glutaminase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:21,806,405...21,820,001
Ensembl chr 5:21,806,406...21,820,001
G
GLT8D1
glycosyltransferase 8 domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:34,828,601...34,839,854
Ensembl chr13:34,828,604...34,839,794
G
GMFG
glia maturation factor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:47,990,241...47,997,332
Ensembl chr 6:47,990,237...47,997,260
G
GNA14
G protein subunit alpha 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:230,341,947...230,545,123
Ensembl chr 1:230,341,942...230,546,120
G
GNAI2
G protein subunit alpha i2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,794
G
GNPDA1
glucosamine-6-phosphate deaminase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:143,604,362...143,616,037
Ensembl chr 2:143,604,362...143,615,990
G
GOT1
glutamic-oxaloacetic transaminase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874
G
GP91-PHOX
NADPH oxidase heavy chain subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:33,654,656...33,678,346
Ensembl chr X:33,643,648...33,680,580
G
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:122,538,600...122,582,390
Ensembl chr14:122,538,491...122,579,436
G
GPNMB
glycoprotein nmb
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:92,037,428...92,071,501
Ensembl chr 9:92,037,509...92,071,499
G
GPR68
G protein-coupled receptor 68
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:112,885,160...112,904,214
Ensembl chr 7:112,885,163...112,904,246
G
GPT
glutamic--pyruvic transaminase
treatment
ISO
RGD
PMID:22706148
RGD:8552768
NCBI chr 4:297,747...302,498
Ensembl chr 4:297,748...320,056
G
GPX8
glutathione peroxidase 8 (putative)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:34,336,154...34,341,861
Ensembl chr16:34,336,073...34,342,403
G
GRK2
G protein-coupled receptor kinase 2
ISO
protein:increased expression:aorta
RGD
PMID:17256744
RGD:1625784
NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758
G
GRN
granulin precursor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:18,893,772...18,900,444
Ensembl chr12:18,893,770...18,900,446
G
GSN
gelsolin
ISO
mRNA, protein:increased expression CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:14574581 PMID:25380136
RGD:1599866
NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848
G
GSTA1
glutathione S-transferase alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,548,670
G
GSTA4
glutathione S-transferase alpha 4
treatment
ISO
RGD
PMID:23075396
RGD:9685568
NCBI chr 7:46,635,903...46,656,491
Ensembl chr 7:46,635,902...46,656,450
G
GULP1
GULP PTB domain containing engulfment adaptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:92,988,094...93,252,188
Ensembl chr15:92,911,054...93,252,180
G
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:34,282,160...34,290,422
Ensembl chr16:34,282,120...34,290,477
G
HAGH
hydroxyacylglutathione hydrolase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:40,139,099...40,162,921
G
HAL
histidine ammonia-lyase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:87,522,483...87,547,489
Ensembl chr 5:87,522,542...87,547,455
G
HAO1
hydroxyacid oxidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:16,746,153...16,802,460
Ensembl chr17:16,744,442...16,802,442
G
HAO2
hydroxyacid oxidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 4:101,588,510...101,787,818
Ensembl chr 4:101,588,861...101,732,304
G
HCK
HCK proto-oncogene, Src family tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:35,708,549...35,751,590
Ensembl chr17:35,709,349...35,751,582
G
HELLS
helicase, lymphoid specific
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:105,923,727...105,967,003
Ensembl chr14:105,924,536...105,955,430
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HEXIM1
HEXIM P-TEFb complex subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:18,267,023...18,270,089
Ensembl chr12:18,267,027...18,269,165
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HGF
hepatocyte growth factor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10677585 PMID:12918455 PMID:15793283 PMID:16465399 PMID:16627068 PMID:17714472 PMID:18637143 More...
NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564
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HIP1
huntingtin interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:10,416,418...10,578,374
Ensembl chr 3:10,416,475...10,578,366
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HJV
hemojuvelin BMP co-receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:99,327,989...99,332,647
Ensembl chr 4:99,328,053...99,332,645
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HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957
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HMOX1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:16025519 PMID:16610050 PMID:19554654 PMID:21163135 PMID:25380136
RGD:4145305
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HOPX
HOP homeobox
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:55,862,191...55,901,628
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HOXA3
homeobox A3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:45,421,542...45,467,803
Ensembl chr18:45,454,213...45,466,537
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HP
haptoglobin
ISO
protein:decreased expression:serum protein:increased expression:serum
RGD
PMID:16968543 PMID:21806828
RGD:1626367 RGD:9491781
NCBI chr 6:14,980,382...14,985,245
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HPCAL1
hippocalcin like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:126,107,407...126,220,381
Ensembl chr 3:126,107,412...126,220,309
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HPGDS
hematopoietic prostaglandin D synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:125,375,906...125,406,066
Ensembl chr 8:125,375,867...125,405,955
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HPSE
heparanase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15095483 PMID:18458672
NCBI chr 8:135,082,199...135,120,887
Ensembl chr 8:135,097,725...135,120,887
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HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 6:6,296,429...6,360,434
Ensembl chr 6:6,292,707...6,360,633
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HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 5:22,089,496...22,114,319
Ensembl chr 5:22,092,578...22,273,382
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HTR2B
5-hydroxytryptamine receptor 2B
ISO
protein:increased expression:liver (rat)
RGD
PMID:16936262
RGD:9743846
NCBI chr15:131,844,578...131,860,417
Ensembl chr15:131,844,992...131,859,277
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HYKK
hydroxylysine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:47,451,822...47,474,778
Ensembl chr 7:47,449,036...47,474,648
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ICAM2
intercellular adhesion molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:14,986,636...14,991,639
Ensembl chr12:14,972,852...14,997,428
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ID2
inhibitor of DNA binding 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17127702
NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,763...127,503,257
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ID4
inhibitor of DNA binding 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:15,281,535...15,284,895
Ensembl chr 7:15,281,757...15,282,839
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IDO1
indoleamine 2,3-dioxygenase 1
severity
ISO
protein:increased expression:serum (mouse)
RGD
PMID:28465467
RGD:39939037
NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,473
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IDUA
alpha-L-iduronidase
ISO
protein:increased expression:liver
RGD
PMID:6875476
RGD:12910840
NCBI chr 8:334,604...351,970
Ensembl chr 8:334,617...351,969
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IFI35
interferon induced protein 35
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:19,879,386...19,890,330
Ensembl chr12:19,879,387...19,890,314
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IFNA1
interferon, alpha 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12898905 PMID:14512876 PMID:16027843
NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488
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IFNG
interferon gamma
ISO
CTD Direct Evidence: therapeutic protein:increased expression:serum (mouse)
CTD RGD
PMID:12389079 PMID:15996030 PMID:16953842 PMID:17347453 PMID:28465467
RGD:39939037
NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
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IFNGR1
interferon gamma receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:27,037,151...27,061,095
Ensembl chr 1:27,037,165...27,061,093
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IFRD1
interferon related developmental regulator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:33,198,002...33,248,912
Ensembl chr18:33,193,426...33,248,297
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IGF1
insulin like growth factor 1
treatment
ISO
CTD Direct Evidence: therapeutic protein:increased expression:liver:
RGD CTD
PMID:12800242 PMID:15591519 PMID:15745444 PMID:16434425 PMID:20198635
RGD:10045984 RGD:12904923 RGD:2317647
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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IGF1R
insulin like growth factor 1 receptor
ISO
protein:increased expression:liver:
RGD
PMID:12800242
RGD:10045984
NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058
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IGF2BP3
insulin like growth factor 2 mRNA binding protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:92,104,786...92,272,264
Ensembl chr 9:92,104,848...92,272,211
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IGF2R
insulin like growth factor 2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:7,369,485...7,472,480
Ensembl chr 1:7,368,103...7,472,548
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IGFALS
insulin like growth factor binding protein acid labile subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:40,173,595...40,177,789
Ensembl chr 3:40,174,764...40,177,784
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IGFBP1
insulin like growth factor binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr18:50,018,487...50,022,799
Ensembl chr18:50,018,487...50,022,799
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IGFBP2
insulin like growth factor binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
G
IGFBP3
insulin like growth factor binding protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:50,002,921...50,009,425
Ensembl chr18:50,003,022...50,010,690
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IGFBP7
insulin like growth factor binding protein 7
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25380136 PMID:25691930
RGD:401976485
NCBI chr 8:56,283,089...56,357,822
Ensembl chr 8:56,279,895...56,357,822
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IGSF6
immunoglobulin superfamily member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:23,673,162...23,683,256
Ensembl chr 3:23,673,148...23,683,864
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IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30737368
NCBI chr X:125,035,575...125,056,445
Ensembl chr X:125,036,508...125,056,453
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IL10
interleukin 10
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12632514 PMID:15362042 PMID:16097045 PMID:16126171 PMID:16539848 PMID:16552806 PMID:16609999 PMID:16688825 PMID:18251166 PMID:23980370 PMID:24993843 More...
RGD:11049490 RGD:7364982
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
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IL17A
interleukin 17A
treatment
ISO
protein:increased expression:liver, serum (mouse)
RGD
PMID:28465467 PMID:30346985
RGD:151665755 RGD:39939037
NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
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IL17RA
interleukin 17 receptor A
treatment
ISO
RGD
PMID:30346985
RGD:151665755
NCBI chr 5:69,461,280...69,480,343
Ensembl chr 5:69,461,290...69,480,112
G
IL17RC
interleukin 17 receptor C
treatment
ISO
RGD
PMID:30346985
RGD:151665755
NCBI chr13:66,179,298...66,194,750
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IL18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
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IL18BP
interleukin 18 binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:6,586,602...6,596,423
Ensembl chr 9:6,488,808...6,591,333
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IL2
interleukin 2
treatment
ISO
RGD
PMID:30346985
RGD:151665755
NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
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IL2RB
interleukin 2 receptor subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:10,610,094...10,650,315
Ensembl chr 5:10,628,962...10,650,314
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IL2RG
interleukin 2 receptor subunit gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:57,143,568...57,151,242
Ensembl chr X:57,143,570...57,147,256
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IL33
interleukin 33
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840
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IL4
interleukin 4
ISO
protein:decreased expression:serum (mouse)
RGD
PMID:28465467
RGD:39939037
NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
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IL6
interleukin 6
treatment
ISO
mRNA:increased expression:liver (mouse)
RGD
PMID:24383550 PMID:28465467 PMID:30346985
RGD:10450610 RGD:151665755 RGD:39939037
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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IL7R
interleukin 7 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:21,300,141...21,330,156
Ensembl chr16:21,300,111...21,329,585
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ILK
integrin linked kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16941698
NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858
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INHBC
inhibin subunit beta C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:22,718,416...22,728,766
Ensembl chr 5:22,718,491...22,730,087
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INHBE
inhibin subunit beta E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 5:22,732,774...22,734,716
Ensembl chr 5:22,732,516...22,734,083
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INMT
indolethylamine N-methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:42,213,335...42,218,175
Ensembl chr18:42,209,352...42,218,174
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INPP5D
inositol polyphosphate-5-phosphatase D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644
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INPPL1
inositol polyphosphate phosphatase like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:6,793,971...6,807,286
Ensembl chr 9:6,793,069...6,808,028
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INS
insulin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26806094
NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
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INSIG2
insulin induced gene 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:23,676,684...23,699,591
Ensembl chr15:23,676,683...23,699,582
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IRF8
interferon regulatory factor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:3,041,617...3,060,685
Ensembl chr 6:3,041,645...3,097,406
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ISG20
interferon stimulated exonuclease gene 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:191,155,853...191,195,601
Ensembl chr 1:191,183,599...191,195,475
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ISYNA1
inositol-3-phosphate synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:59,363,672...59,367,003
Ensembl chr 2:59,363,716...59,367,002
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ITGA2B
integrin subunit alpha 2b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:18,860,739...18,877,381
Ensembl chr12:18,860,739...18,877,381
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ITGAL
integrin subunit alpha L
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:17,817,785...17,858,057
Ensembl chr 3:17,817,011...17,858,012
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ITGB1
integrin subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326
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ITGB2
integrin subunit beta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107
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ITGB3
integrin subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292
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ITGB6
integrin subunit beta 6
ISO
mRNA, protein:increased expression:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18221819 PMID:18538673
RGD:2302244
NCBI chr15:67,041,516...67,175,409
Ensembl chr15:67,041,522...67,175,234
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IVD
isovaleryl-CoA dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:130,896,488...130,910,582
Ensembl chr 1:130,893,984...130,910,586
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IYD
iodotyrosine deiodinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:15,756,536...15,779,380
Ensembl chr 1:15,756,550...15,779,164
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JAK2
Janus kinase 2
ISO
protein:increased expression, increased tyrosine phosphorylation:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:24619965 PMID:25380136
RGD:10403061
NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148
G
JDP2
Jun dimerization protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:98,574,386...98,616,480
Ensembl chr 7:98,575,667...98,616,474
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KANK1
KN motif and ankyrin repeat domains 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:221,015,042...221,218,875
Ensembl chr 1:221,015,046...221,078,245
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KCNJ8
potassium inwardly rectifying channel subfamily J member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:51,695,927...51,704,402
Ensembl chr 5:51,696,188...51,703,813
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KCNN4
potassium calcium-activated channel subfamily N member 4
exacerbates
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:27354175
RGD:329955558
NCBI chr 6:50,580,016...50,593,518
Ensembl chr 6:50,580,022...50,593,544
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KLF6
KLF transcription factor 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:66,488,445...66,497,830
Ensembl chr10:66,488,391...66,497,844
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KMO
kynurenine 3-monooxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:12,442,877...12,489,417
Ensembl chr10:12,442,645...12,490,409
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KNG1
kininogen 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18054572
NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
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KRT18
keratin 18
ISO
protein:increased expression:liver, plasma membrane (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15999547 PMID:17072980 PMID:18395095 PMID:21138630 PMID:25380136
RGD:27226809
NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429
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KRT19
keratin 19
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:21,115,453...21,119,115
Ensembl chr12:21,115,448...21,119,107
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KRT8
keratin 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 5:18,172,423...18,180,277
Ensembl chr 5:18,167,553...18,180,404
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KTN1
kinectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:184,881,555...184,990,936
Ensembl chr 1:184,881,550...185,152,975
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KYNU
kynureninase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:8,847,335...8,982,951
Ensembl chr15:8,850,544...8,982,891
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L3HYPDH
trans-L-3-hydroxyproline dehydratase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:188,584,363...188,616,688
Ensembl chr 1:188,584,377...188,610,002
G
LAPTM5
lysosomal protein transmembrane 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:87,363,911...87,390,371
Ensembl chr 6:87,363,911...87,390,347
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LBH
LBH regulator of WNT signaling pathway
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:109,078,285...109,113,536
Ensembl chr 3:109,078,286...109,105,529
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LBP
lipopolysaccharide binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,398,791...41,429,551
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LCN2
lipocalin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644
G
LCP1
lymphocyte cytosolic protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:21,126,504...21,223,543
Ensembl chr11:21,126,539...21,223,550
G
LCP2
lymphocyte cytosolic protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:53,696,974...53,741,736
Ensembl chr16:53,697,026...53,741,725
G
LDHB
lactate dehydrogenase B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:51,810,932...51,831,218
G
LEFTY2
left-right determination factor 2
ameliorates
ISO
RGD
PMID:34887753
RGD:401794438
NCBI chr10:13,849,052...13,853,438
Ensembl chr10:13,848,174...13,853,438
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LEP
leptin
disease_progression
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12586293 PMID:16097051 PMID:19065677 PMID:20509998 PMID:29248466
RGD:5128589 RGD:5128713
NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323
G
LEPR
leptin receptor
ISO
protein:increased expression:serum
RGD
PMID:23886859
RGD:10412036
NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995
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LGALS1
galectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:10,149,069...10,152,514
Ensembl chr 5:10,149,068...10,156,023
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LGALS2
galectin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:10,237,772...10,244,555
Ensembl chr 5:10,237,745...10,250,162
G
LGALS3
galectin 3
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12646584 PMID:16549783 PMID:25380136
RGD:9685223 RGD:9685224
NCBI chr 1:184,478,639...184,496,155
Ensembl chr 1:184,478,710...184,497,951
G
LGALSL
galectin like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:77,472,153...77,479,415
Ensembl chr 3:77,472,166...77,479,361
G
LGMN
legumain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:114,176,217...114,210,096
Ensembl chr 7:114,173,693...114,217,102
G
LHFPL6
LHFPL tetraspan subfamily member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:14,319,420...14,576,130
Ensembl chr11:14,319,428...14,560,181
G
LIMK2
LIM domain kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:47,983,984...48,039,631
Ensembl chr14:47,983,975...48,040,821
G
LIN7A
lin-7 homolog A, crumbs cell polarity complex component
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:100,533,630...100,686,709
Ensembl chr 5:100,538,065...100,674,551
G
LMO2
LIM domain only 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:27,033,924...27,055,457
Ensembl chr 2:27,044,763...27,055,453
G
LOC100157117
kallistatin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:115,781,772...115,792,469
Ensembl chr 7:115,783,931...115,792,466
G
LOC100512795
alcohol dehydrogenase class 4 mu/sigma chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:121,020,683...121,041,735
Ensembl chr 8:121,020,969...121,041,506
G
LOC100519934
uncharacterized LOC100519934
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:73,119,758...73,124,368
G
LOC100522887
caspase-13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:35,167,567...35,185,791
G
LOC100623616
arylacetamide deacetylase-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:92,017,495...92,042,944
Ensembl chr13:92,017,548...92,042,938
G
LOC100623720
collagen alpha-1(VI) chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,451...208,313,127
G
LOC100625684
olfactory receptor 51E2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:5,431,098...5,434,483
Ensembl chr 9:5,432,611...5,433,573
G
LOC102161418
interferon-induced transmembrane protein 1-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:156,364...157,650
G
LOC110255211
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:25,334,619...25,340,775
G
LOC110256626
proline dehydrogenase 1, mitochondrial
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:51,624,919...51,644,467
G
LOC110258578
interleukin-1 beta-like
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16085334 PMID:24383550
RGD:10450610
G
LOC110258709
C-type lectin domain family 4 member A-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
LOX
lysyl oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:125,595,115...125,607,026
Ensembl chr 2:125,591,789...125,607,594
G
LOXL2
lysyl oxidase like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:7,435,861...7,540,699
Ensembl chr14:7,435,867...7,540,704
G
LPL
lipoprotein lipase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:4,104,761...4,134,964
Ensembl chr14:4,104,772...4,135,814
G
LPXN
leupaxin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:12,534,780...12,582,756
Ensembl chr 2:12,540,098...12,582,752
G
LRAT
lecithin retinol acyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:74,412,226...74,428,713
Ensembl chr 8:74,409,461...74,419,681
G
LRP6
LDL receptor related protein 6
ISO
RGD
PMID:18006602
RGD:4110127
NCBI chr 5:60,149,041...60,318,719
Ensembl chr 5:60,149,028...60,314,662
G
LRRC28
leucine rich repeat containing 28
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:137,998,540...138,194,848
Ensembl chr 1:137,998,554...138,203,466
G
LRRFIP1
LRR binding FLII interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:137,283,262...137,439,383
Ensembl chr15:137,283,276...137,439,385
G
LTA4H
leukotriene A4 hydrolase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
G
LTB
lymphotoxin beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:23,704,842...23,707,036
Ensembl chr 7:23,704,841...23,706,745
G
LTBP1
latent transforming growth factor beta binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:106,300,748...106,724,538
Ensembl chr 3:106,300,750...106,724,737
G
LUM
lumican
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:91,748,871...91,756,381
Ensembl chr 5:91,748,885...91,757,598
G
LURAP1L
leucine rich adaptor protein 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:209,621,712...209,668,924
Ensembl chr 1:209,620,907...209,668,913
G
LY86
lymphocyte antigen 86
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:4,108,124...4,156,629
Ensembl chr 7:4,108,118...4,156,625
G
LY96
lymphocyte antigen 96
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:61,919,806...61,950,712
Ensembl chr 4:61,926,064...61,950,697
G
MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
G
MAP3K8
mitogen-activated protein kinase kinase kinase 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:40,714,004...40,746,390
Ensembl chr10:40,713,847...40,742,462
G
MAPK1
mitogen-activated protein kinase 1
treatment
ISO
RGD
PMID:27396351
RGD:13800880
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
G
MAPK3
mitogen-activated protein kinase 3
treatment
ISO
RGD
PMID:27396351
RGD:13800880
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
G
MAS1
MAS1 proto-oncogene, G protein-coupled receptor
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:19793108
RGD:2316776
NCBI chr 1:7,527,566...7,542,110
Ensembl chr 1:7,527,861...7,528,838
G
MDH1
malate dehydrogenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:78,247,229...78,263,085
Ensembl chr 3:78,244,999...78,268,600
G
MEOX2
mesenchyme homeobox 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:84,945,178...85,009,939
Ensembl chr 9:84,943,199...85,010,157
G
MET
MET proto-oncogene, receptor tyrosine kinase
ISO
protein:decreased expression:liver (rat)
RGD
PMID:16958060
RGD:2317516
NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512
G
METRNL
meteorin like, glial cell differentiation regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:228,228...241,491
Ensembl chr12:228,503...241,496
G
MFAP4
microfibril associated protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:60,141,488...60,144,214
Ensembl chr12:60,137,566...60,144,207
G
MFN2
mitofusin 2
treatment
ISO
mRNA, protein:decreased expression:liver (rat)
RGD
PMID:25369251 PMID:26882442
RGD:12910839 RGD:13204798
NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438
G
MGAT5
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23798564
NCBI chr15:17,544,806...17,919,273
Ensembl chr15:17,544,806...17,918,555
G
MGMT
O-6-methylguanine-DNA methyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540
G
MGP
matrix Gla protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:57,665,272...57,669,360
Ensembl chr 5:57,665,248...57,669,764
G
MID1IP1
MID1 interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:34,763,360...34,766,160
Ensembl chr X:34,763,355...34,766,076
G
MIF
macrophage migration inhibitory factor
ISO
protein:increased expression:hepatocyte
RGD
PMID:14706927
RGD:1642000
NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068
G
MINDY3
MINDY lysine 48 deubiquitinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:45,980,088...46,062,700
Ensembl chr10:45,980,111...46,062,700
G
MIR122
microRNA mir-122
treatment
ISO
RGD
PMID:28987423
RGD:14401600
NCBI chr 1:162,329,776...162,329,860
Ensembl chr 1:162,329,767...162,329,860
G
MIR152
microRNA mir-152
treatment
ISO
miRNA:decreased expression:liver
RGD
PMID:26257392 PMID:31258681
RGD:19165150 RGD:19165153
NCBI chr12:24,292,249...24,292,328
Ensembl chr12:24,292,251...24,292,336
G
MIR17
microRNA mir-17
treatment
ISO
RGD
PMID:28177765
RGD:329403059
NCBI chr11:60,734,656...60,734,732
Ensembl chr11:60,734,656...60,734,732
G
MIR30A
microRNA mir-30a
treatment
ISO
RGD
PMID:29587268
RGD:35673290
NCBI chr 1:51,412,827...51,412,933
Ensembl chr 1:51,412,827...51,412,933
G
MIS12
MIS12 kinetochore complex component
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:51,505,376...51,508,337
Ensembl chr12:51,505,381...51,507,943
G
MKI67
marker of proliferation Ki-67
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:137,266,622...137,296,312
G
MME
membrane metalloendopeptidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16085334
NCBI chr13:95,018,395...95,122,977
Ensembl chr13:95,019,081...95,126,045
G
MMP1
matrix metallopeptidase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12557150
NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,420,076
G
MMP13
matrix metallopeptidase 13
treatment
ISO
CTD Direct Evidence: therapeutic
RGD CTD
PMID:10623612 PMID:17404313
RGD:10043161
NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162
G
MMP15
matrix metallopeptidase 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:19,890,867...19,912,941
Ensembl chr 6:19,891,107...19,912,913
G
MMP2
matrix metallopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15095483 PMID:25380136
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
G
MMP8
matrix metallopeptidase 8
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15057751
NCBI chr 9:33,384,034...33,397,637
Ensembl chr 9:33,384,033...33,396,947
G
MMP9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15095483
NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
G
MOB3A
MOB kinase activator 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:76,475,397...76,495,015
Ensembl chr 2:76,475,530...76,496,060
G
MRO
maestro
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:100,342,040...100,368,355
Ensembl chr 1:100,343,462...100,368,354
G
MSN
moesin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:51,844,197...51,967,674
Ensembl chr X:51,844,156...51,970,107
G
MT-2B
metallothionein-2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:18,645,125...18,646,034
Ensembl chr 6:18,645,153...18,646,033
G
MT-CYB
mitochondrially encoded cytochrome b
ISO
protein:increased expression:mitochondrion, liver
RGD
PMID:2836123
RGD:2298972
NCBI chr MT:15,342...16,481
Ensembl chr MT:15,342...16,481
G
MT1A
metallothionein 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672
G
MTMR7
myotubularin related protein 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:5,007,560...5,122,367
Ensembl chr17:5,006,623...5,122,201
G
MTOR
mechanistic target of rapamycin kinase
treatment
ISO
RGD
PMID:25454463
RGD:10040998
NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
G
MVP
major vault protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:18,056,548...18,081,169
Ensembl chr 3:18,057,177...18,081,155
G
MYADM
myeloid associated differentiation marker
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:56,236,306...56,278,577
Ensembl chr 6:56,236,311...56,244,185
G
MYC
MYC proto-oncogene, bHLH transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
G
MYL9
myosin light chain 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
G
MYO1C
myosin IC
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:47,691,252...47,715,670
Ensembl chr12:47,691,256...47,718,337
G
MYO1F
myosin IF
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:70,753,143...70,792,938
Ensembl chr 2:70,753,138...70,792,936
G
MYO5A
myosin VA
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:119,165,751...119,398,591
Ensembl chr 1:119,165,942...119,394,725
G
MYOC
myocilin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,378...114,098,745
G
NAGK
N-acetylglucosamine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:71,496,191...71,513,020
Ensembl chr 3:71,500,337...71,512,955
G
NAP1L5
nucleosome assembly protein 1 like 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:130,364,566...130,365,464
Ensembl chr 8:130,364,566...130,365,464
G
NAT8
N-acetyltransferase 8 (putative)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:69,250,326...69,254,079
G
NBEA
neurobeachin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:11,085,081...11,722,859
Ensembl chr11:11,084,992...11,722,847
G
NCKAP1L
NCK associated protein 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:19,677,613...19,720,550
Ensembl chr 5:19,677,875...19,723,132
G
NCOR2
nuclear receptor corepressor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:28,642,774...28,819,404
Ensembl chr14:28,624,702...28,819,404
G
NDRG1
N-myc downstream regulated 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:8,014,445...8,069,335
Ensembl chr 4:8,014,446...8,069,335
G
NDRG2
NDRG family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:78,111,736...78,121,216
Ensembl chr 7:78,112,536...78,121,215
G
NECTIN2
nectin cell adhesion molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:51,317,386...51,358,665
G
NEK6
NIMA related kinase 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:265,078,407...265,170,960
Ensembl chr 1:265,078,435...265,176,903
G
NFE2L2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23341968
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
G
NFKBIA
NFKB inhibitor alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26806094
NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277
G
NFKBIE
NFKB inhibitor epsilon
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:39,255,078...39,266,085
Ensembl chr 7:39,255,075...39,263,339
G
NFKBIZ
NFKB inhibitor zeta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:157,261,419...157,273,119
Ensembl chr13:157,261,419...157,272,688
G
NHSL3
NHS like 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:89,058,857...89,087,840
Ensembl chr 6:89,058,808...89,087,839
G
NID1
nidogen 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:55,239,327...55,346,948
Ensembl chr14:55,239,577...55,390,782
G
NID2
nidogen 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:181,699,098...181,773,084
Ensembl chr 1:181,699,106...181,815,167
G
NIPAL2
NIPA like domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:38,491,029...38,576,606
Ensembl chr 4:38,491,285...38,574,255
G
NLRC5
NLR family CARD domain containing 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26806094
NCBI chr 6:18,933,179...19,036,288
Ensembl chr 6:18,937,677...19,036,820
G
NMI
N-myc and STAT interactor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:941,379...966,519
Ensembl chr15:941,475...967,321
G
NOCT
nocturnin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:87,885,411...87,909,231
Ensembl chr 8:87,885,420...87,909,241
G
NOS2
nitric oxide synthase 2
ISO
mRNA:increased expression:aorta mRNA:increased expression:heart CTD Direct Evidence: therapeutic
RGD CTD
PMID:10353629 PMID:10784593 PMID:18380797
RGD:2325265 RGD:2325278
NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
G
NOS3
nitric oxide synthase 3
ISO
protein:decreased expression:liver protein:decreased expression:spleen CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17481668 PMID:17918268 PMID:18555214
RGD:2292126 RGD:2292140
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
G
NOX4
NADPH oxidase 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,212...22,776,534
G
NPAS2
neuronal PAS domain protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:53,298,805...53,490,375
Ensembl chr 3:53,298,811...53,490,574
G
NPDC1
neural proliferation, differentiation and control 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
NQO2
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:1,792,745...1,805,916
Ensembl chr 7:1,792,876...1,806,301
G
NR0B2
nuclear receptor subfamily 0 group B member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 6:84,225,670...84,228,156
Ensembl chr 6:84,225,694...84,228,481
G
NR1H4
nuclear receptor subfamily 1 group H member 4
treatment
ISO
mRNA:altered expression:liver (rat) associated with portal hypertension;mRNA;decreased expression;liver (rat)
RGD
PMID:15980055 PMID:24259407 PMID:27993716
RGD:14701034 RGD:15045598 RGD:1625201
NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604
G
NREP
neuronal regeneration related protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:117,505,851...117,867,805
Ensembl chr 2:117,838,660...117,867,801
G
NRG1
neuregulin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505
G
NRROS
negative regulator of reactive oxygen species
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:133,470,641...133,496,218
Ensembl chr13:133,470,645...133,496,223
G
NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
NT5E
5'-nucleotidase ecto
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18263696
NCBI chr 1:54,400,786...54,450,743
Ensembl chr 1:54,400,810...54,448,742
G
NUDT16
nudix hydrolase 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:1,125,180...1,128,036
Ensembl chr13:1,125,183...1,128,041
G
NUPR1
nuclear protein 1, transcriptional regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:18,402,781...18,404,411
Ensembl chr 3:18,402,935...18,511,087
G
OAT
ornithine aminotransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:133,808,193...133,830,517
Ensembl chr14:133,808,193...133,830,761
G
OGG1
8-oxoguanine DNA glycosylase
treatment
ISO
RGD
PMID:23053977
RGD:8657403
NCBI chr13:66,038,669...66,045,478
G
OLFML2B
olfactomedin like 2B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:88,522,171...88,560,305
Ensembl chr 4:88,522,240...88,560,306
G
OLFML3
olfactomedin like 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:106,566,978...106,571,086
Ensembl chr 4:106,563,450...106,569,771
G
OSGIN1
oxidative stress induced growth inhibitor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:4,642,762...4,656,113
Ensembl chr 6:4,642,764...4,653,487
G
OSM
oncostatin M
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17640959
NCBI chr14:47,242,767...47,246,836
Ensembl chr14:47,242,774...47,246,838
G
OTC
ornithine transcarbamylase
ISO
CTD Direct Evidence: marker/mechanism protein:decreased activity:liver (rat)
CTD RGD
PMID:7865721 PMID:25380136
RGD:4144080
NCBI chr X:34,322,398...34,391,711
Ensembl chr X:34,322,298...34,391,821
G
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:115,304,809...115,326,055
Ensembl chr 7:115,304,871...115,327,054
G
OTULINL
OTU deubiquitinase with linear linkage specificity like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:3,964,300...4,000,673
Ensembl chr16:3,969,932...3,999,778
G
PALMD
palmdelphin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:118,377,246...118,427,800
Ensembl chr 4:118,377,248...118,428,086
G
PAMR1
peptidase domain containing associated with muscle regeneration 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:25,422,390...25,591,615
Ensembl chr 2:25,514,193...25,591,617
G
PAQR9
progestin and adipoQ receptor family member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:83,660,387...83,669,522
Ensembl chr13:83,667,736...83,668,869
G
PC
pyruvate carboxylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 2:5,566,608...5,587,797
Ensembl chr 2:5,518,517...5,587,797
G
PCK1
phosphoenolpyruvate carboxykinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,936,522
G
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:75,187,195...75,197,613
Ensembl chr 7:75,187,197...75,197,733
G
PDGFA
platelet derived growth factor subunit A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:296,399...322,967
Ensembl chr 3:301,584...321,712
G
PDGFRA
platelet derived growth factor receptor alpha
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17382907 PMID:25380136
RGD:11080969
NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,441
G
PDGFRB
platelet derived growth factor receptor beta
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15077122 PMID:15623374 PMID:18466260
RGD:10449503 RGD:2292206
NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,756...151,192,647
G
PDZRN3
PDZ domain containing ring finger 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:54,659,657...54,904,742
Ensembl chr13:54,659,589...54,904,809
G
PEA15
proliferation and apoptosis adaptor protein 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:90,263,600...90,276,142
Ensembl chr 4:90,263,604...90,276,147
G
PFKP
phosphofructokinase, platelet
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:67,022,652...67,082,336
Ensembl chr10:67,022,655...67,082,449
G
PFN1
profilin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464
G
PGF
placental growth factor
disease_progression
ISO
RGD
PMID:17935226 PMID:21520176
RGD:1643338 RGD:6483607
NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741
G
PKD2
polycystin 2, transient receptor potential cation channel
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:131,002,973...131,058,932
Ensembl chr 8:131,005,407...131,058,932
G
PKLR
pyruvate kinase L/R
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:94,536,978...94,546,561
Ensembl chr 4:94,537,019...94,546,555
G
PLA2G12A
phospholipase A2 group XIIA
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:112,483,322...112,512,520
Ensembl chr 8:112,483,392...112,512,419
G
PLA2G4A
phospholipase A2 group IVA
ISO
protein:increased activity:liver CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17459512 PMID:25380136
RGD:1642445
NCBI chr 9:127,853,581...128,164,825
Ensembl chr 9:127,859,051...128,162,638
G
PLAC8
placenta associated 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:135,250,761...135,279,091
G
PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20035854 PMID:25380136
RGD:6484134
NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032
G
PLAU
plasminogen activator, urokinase
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16958060 PMID:20035854 PMID:23018346 PMID:25380136
RGD:2317516 RGD:6484134 RGD:7241553
NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
G
PLD4
phospholipase D family member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
PLEK
pleckstrin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:73,877,741...73,910,163
Ensembl chr 3:73,877,743...73,906,667
G
PLEKHB1
pleckstrin homology domain containing B1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:8,103,497...8,117,819
Ensembl chr 9:8,102,056...8,117,815
G
PLG
plasminogen
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:14716496
NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,192...7,110,555
G
PLIN2
perilipin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273
G
PLIN3
perilipin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:73,970,149...73,995,314
Ensembl chr 2:73,969,862...73,995,529
G
PLOD2
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:86,402,673...86,513,167
Ensembl chr13:86,401,244...86,513,105
G
PLPP2
phospholipid phosphatase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:77,945,760...77,957,318
Ensembl chr 2:77,945,841...77,957,313
G
PLSCR1
phospholipid scramblase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:86,836,288...86,869,569
Ensembl chr13:86,834,587...86,869,297
G
PLTP
phospholipid transfer protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:48,089,789...48,101,604
Ensembl chr17:48,089,786...48,101,515
G
PMEPA1
prostate transmembrane protein, androgen induced 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:57,999,287...58,054,329
Ensembl chr17:57,999,287...58,054,118
G
POMC
proopiomelanocortin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16508911 PMID:16511523
NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418
G
PPARG
peroxisome proliferator activated receptor gamma
treatment
ISO
RGD
PMID:18594976 PMID:22529699
RGD:2301874 RGD:8553190
NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
G
PPP1R16A
protein phosphatase 1 regulatory subunit 16A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056
G
PPP1R18
protein phosphatase 1 regulatory subunit 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:23,211,806...23,222,295
Ensembl chr 7:23,211,805...23,222,186
G
PPP1R3B
protein phosphatase 1 regulatory subunit 3B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:56,002,383...56,013,477
Ensembl chr15:56,002,378...56,013,478
G
PPP1R3C
protein phosphatase 1 regulatory subunit 3C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:103,273,401...103,278,757
Ensembl chr14:103,273,405...103,278,762
G
PRAF2
PRA1 domain family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:43,147,473...43,150,350
G
PRKCB
protein kinase C beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264
G
PRKCD
protein kinase C delta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356
G
PRKN
parkin RBR E3 ubiquitin protein ligase
treatment
ISO
RGD
PMID:26882442
RGD:12910839
NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872
G
PRLR
prolactin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:20,637,568...20,655,881
Ensembl chr16:20,618,875...20,810,140
G
PRNP
prion protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:13,694,195...13,705,126
Ensembl chr17:13,694,190...13,705,124
G
PROCR
protein C receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:38,532,530...38,537,397
Ensembl chr17:38,532,763...38,537,394
G
PRODH2
proline dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:45,213,712...45,240,437
G
PROS1
protein S
ISO
mRNA, protein:decreased expression:liver, plasma
RGD
PMID:16995903
RGD:2300011
NCBI chr13:165,915,298...165,999,118
Ensembl chr13:165,911,366...165,999,811
G
PRR13
proline rich 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:18,660,814...18,665,926
Ensembl chr 5:18,660,814...18,665,925
G
PRTFDC1
phosphoribosyl transferase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:50,365,654...50,458,487
Ensembl chr10:50,365,587...50,461,324
G
PRTG
protogenin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:116,132,269...116,275,678
Ensembl chr 1:116,132,165...116,268,631
G
PRUNE2
prune homolog 2 with BCH domain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:229,578,444...229,849,222
G
PSMB10
proteasome 20S subunit beta 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:28,544,910...28,547,609
Ensembl chr 6:28,543,972...28,548,152
G
PSMB8
proteasome 20S subunit beta 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:25,058,456...25,061,666
Ensembl chr 7:25,058,461...25,062,245
G
PSMB9
proteasome 20S subunit beta 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:25,072,133...25,077,508
Ensembl chr 7:25,072,323...25,078,322
G
PSME2
proteasome activator subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:75,154,570...75,157,871
Ensembl chr 7:75,153,965...75,157,870
G
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:57,100,212...57,145,278
Ensembl chr 7:57,102,757...57,146,751
G
PTAFR
platelet activating factor receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:85,235,390...85,272,360
Ensembl chr 6:85,235,394...85,261,760
G
PTER
phosphotriesterase related
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:45,368,515...45,440,294
Ensembl chr10:45,362,928...45,440,215
G
PTGER2
prostaglandin E receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:181,993,961...182,009,959
Ensembl chr 1:181,994,560...182,009,953
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17565644 PMID:18555214
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
G
PTK2
protein tyrosine kinase 2
ISO
mRNA, protein:increased expression:liver
RGD
PMID:15378782
RGD:2292604
NCBI chr 4:2,656,606...2,896,060
Ensembl chr 4:2,656,614...2,896,054
G
PTN
pleiotrophin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,787...12,309,044
G
PTPN1
protein tyrosine phosphatase non-receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26739621
NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736
G
PTPN18
protein tyrosine phosphatase non-receptor type 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:31,945,901...31,966,571
Ensembl chr15:31,945,897...31,965,753
G
PTPRC
protein tyrosine phosphatase receptor type C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308
G
PTPRD
protein tyrosine phosphatase receptor type D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:211,832,409...214,013,013
Ensembl chr 1:213,483,348...214,009,893
G
PTPRO
protein tyrosine phosphatase receptor type O
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:57,021,819...57,263,395
Ensembl chr 5:57,019,745...57,263,346
G
PTRH1
peptidyl-tRNA hydrolase 1 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:268,213,685...268,215,498
Ensembl chr 1:268,213,687...268,215,523
G
PTRHD1
peptidyl-tRNA hydrolase domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:113,979,174...113,982,943
G
PXDN
peroxidasin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:132,306,288...132,362,853
Ensembl chr 3:132,306,447...132,362,841
G
PYCARD
PYD and CARD domain containing
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786
G
PYCR1
pyrroline-5-carboxylate reductase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:1,060,028...1,064,808
Ensembl chr12:1,060,570...1,064,805
G
R3HDM2
R3H domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:22,558,645...22,714,250
Ensembl chr 5:22,549,010...22,719,054
G
RAB30
RAB30, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:17,124,181...17,222,741
Ensembl chr 9:17,128,797...17,222,775
G
RAB31
RAB31, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:98,278,644...98,385,857
Ensembl chr 6:98,278,647...98,385,795
G
RAB32
RAB32, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:19,076,301...19,097,647
Ensembl chr 1:19,075,271...19,097,870
G
RAB40B
RAB40B, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:492,298...516,965
Ensembl chr12:493,315...516,962
G
RAB8B
RAB8B, member RAS oncogene family
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:108,772,851...108,840,222
Ensembl chr 1:108,772,851...108,840,227
G
RABGAP1L
RAB GTPase activating protein 1 like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:116,402,395...117,060,057
Ensembl chr 9:116,463,779...117,060,053
G
RAC2
Rac family small GTPase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:10,553,986...10,571,082
Ensembl chr 5:10,553,433...10,573,014
G
RAMP1
receptor activity modifying protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:137,490,440...137,535,555
Ensembl chr15:137,490,356...137,535,553
G
RAMP2
receptor activity modifying protein 2
ISO
RGD
PMID:16713642
RGD:1625319
NCBI chr12:20,092,204...20,094,426
Ensembl chr12:20,092,196...20,094,469
G
RARRES1
retinoic acid receptor responder 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:98,461,307...98,506,552
Ensembl chr13:98,461,320...98,506,173
G
RASSF4
Ras association domain family member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:91,103,518...91,138,501
Ensembl chr14:91,103,526...91,125,360
G
RBL2
RB transcriptional corepressor like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:31,757,718...31,802,047
Ensembl chr 6:31,748,739...31,802,022
G
RBM3
RNA binding motif protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:42,704,019...42,707,587
Ensembl chr X:42,704,028...42,707,577
G
RBP4
retinol binding protein 4
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:17337499
RGD:329845879
NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765
G
RCN1
reticulocalbin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:28,696,528...28,714,083
Ensembl chr 2:28,696,661...28,709,672
G
RCN2
reticulocalbin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:57,040,872...57,058,277
Ensembl chr 7:57,041,003...57,059,330
G
RCSD1
RCSD domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:83,322,175...83,404,102
Ensembl chr 4:83,324,187...83,404,102
G
RDH10
retinol dehydrogenase 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:62,569,877...62,600,981
Ensembl chr 4:62,569,885...62,601,439
G
RDH13
retinol dehydrogenase 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27865848
NCBI chr 6:59,274,383...59,293,139
Ensembl chr 6:59,274,387...59,292,765
G
RECK
reversion inducing cysteine rich protein with kazal motifs
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:236,821,243...236,898,280
Ensembl chr 1:236,821,414...236,898,276
G
REEP5
receptor accessory protein 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:116,845,681...116,886,361
Ensembl chr 2:116,845,571...116,886,358
G
RELA
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26806094
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
G
RELL1
RELT like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:29,118,511...29,190,591
Ensembl chr 8:29,118,514...29,190,565
G
RELN
reelin
ISO
mRNA, protein:increased expression:liver, plasma (rat)
RGD
PMID:18449964
RGD:2317777
NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,863...103,963,883
G
RGN
regucalcin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr X:41,725,660...41,749,736
Ensembl chr X:41,726,526...41,749,381
G
RGS10
regulator of G protein signaling 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:129,386,717...129,424,150
Ensembl chr14:129,381,208...129,423,702
G
RGS2
regulator of G protein signaling 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
G
RGS3
regulator of G protein signaling 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:254,078,618...254,211,805
Ensembl chr 1:254,067,492...254,211,805
G
RGS5
regulator of G protein signaling 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:87,286,953...87,340,816
Ensembl chr 4:87,286,953...87,342,088
G
RHOA
ras homolog family member A
ISO
mRNA, protein:increased expression:liver
RGD
PMID:16492715 PMID:17596891
RGD:1642803 RGD:2298879
NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607
G
RHOQ
ras homolog family member Q
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:93,970,545...94,012,660
Ensembl chr 3:93,973,653...94,012,580
G
RIDA
reactive intermediate imine deaminase A homolog
treatment
ISO
RGD
PMID:23075396
RGD:9685568
NCBI chr 4:38,656,270...38,665,863
Ensembl chr 4:38,656,319...38,670,987
G
RIT1
Ras like without CAAX 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:94,117,721...94,127,882
Ensembl chr 4:94,117,882...94,127,384
G
RMDN2
regulator of microtubule dynamics 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:102,210,367...102,307,355
Ensembl chr 3:102,215,140...102,424,775
G
RMND5B
required for meiotic nuclear division 5 homolog B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:80,226,047...80,247,358
Ensembl chr 2:80,225,496...80,246,945
G
RNASE4
ribonuclease A family member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 7:78,244,284...78,244,931
Ensembl chr 7:78,243,691...78,244,930
G
RNASEL
ribonuclease L
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:123,895,045...123,910,386
Ensembl chr 9:123,893,294...123,910,398
G
RNF39
ring finger protein 39
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:22,637,732...22,642,427
Ensembl chr 7:22,636,904...22,642,612
G
ROBO2
roundabout guidance receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:177,365,712...179,040,027
Ensembl chr13:177,365,772...179,013,542
G
RPH3AL
rabphilin 3A like (without C2 domains)
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr12:47,322,505...47,497,904
Ensembl chr12:47,388,582...47,497,902
G
RSRP1
arginine and serine rich protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:82,850,947...82,861,578
Ensembl chr 6:82,850,949...82,854,270
G
RTN4
reticulon 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:86,180,022...86,252,126
Ensembl chr 3:86,180,022...86,252,126
G
RTP3
receptor transporter protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:29,471,568...29,476,277
G
RXRA
retinoid X receptor alpha
ISO
RGD
PMID:15566521
RGD:1643114
NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620
G
S100A10
S100 calcium binding protein A10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:97,261,752...97,272,517
Ensembl chr 4:97,261,815...97,272,513
G
S100A11
S100 calcium binding protein A11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:97,233,833...97,239,081
Ensembl chr 4:97,233,811...97,243,423
G
S100A6
S100 calcium binding protein A6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:96,098,264...96,099,686
Ensembl chr 4:96,098,525...96,099,684
G
S100A9
S100 calcium binding protein A9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:96,236,114...96,238,989
G
S1PR1
sphingosine-1-phosphate receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:117,064,632...117,069,724
Ensembl chr 4:117,064,755...117,069,650
G
SAMD11
sterile alpha motif domain containing 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:63,287,449...63,308,231
Ensembl chr 6:63,287,713...63,308,482
G
SASH3
SAM and SH3 domain containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:106,373,871...106,389,454
Ensembl chr X:106,373,954...106,389,444
G
SCD
stearoyl-CoA desaturase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020
G
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:6,387,280...6,400,371
Ensembl chr 6:6,387,363...6,399,629
G
SDS
serine dehydratase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:38,503,922...38,513,908
Ensembl chr14:38,503,933...38,513,878
G
SELENOM
selenoprotein M
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:47,902,862...47,905,350
Ensembl chr14:47,902,864...47,905,440
G
SELENOP
selenoprotein P
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:27,537,885...27,547,863
Ensembl chr16:27,537,885...27,631,130
G
SELENOW
selenoprotein W
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:53,470,563...53,474,662
Ensembl chr 6:53,470,787...53,474,652
G
SELP
selectin P
ISO
protein:increased expression:bone marrow
RGD
PMID:19333758
RGD:2312308
NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955
G
SEMA6D
semaphorin 6D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:123,987,528...124,586,062
Ensembl chr 1:123,987,528...124,043,986
G
SENP2
SUMO specific peptidase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29535048
NCBI chr13:123,429,915...123,469,913
Ensembl chr13:123,429,995...123,471,926
G
SERPINA6
serpin family A member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:115,535,552...115,554,536
Ensembl chr 7:115,535,697...115,554,570
G
SERPINA7
serpin family A member 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:86,708,624...86,714,324
Ensembl chr X:86,708,632...86,714,329
G
SERPINB9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:1,723,302...1,732,562
Ensembl chr 7:1,721,383...1,735,074
G
SERPINC1
serpin family C member 1
treatment
ISO
associated with Inflammatory Bowel Diseases
RGD
PMID:16124052
RGD:1599330
NCBI chr 9:116,181,988...116,193,100
Ensembl chr 9:116,181,670...116,193,201
G
SERPINH1
serpin family H member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18376398 PMID:25380136
NCBI chr 9:9,782,939...9,794,485
Ensembl chr 9:9,783,042...9,794,483
G
SEZ6
seizure related 6 homolog
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:45,178,292...45,223,829
Ensembl chr12:45,178,313...45,203,216
G
SGCB
sarcoglycan beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:39,130,371...39,148,756
Ensembl chr 8:39,127,545...39,148,814
G
SGK2
serum/glucocorticoid regulated kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:46,188,160...46,208,807
Ensembl chr17:46,188,265...46,208,804
G
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:83,687,473...83,689,076
Ensembl chr 6:83,687,604...83,689,565
G
SHCBP1
SHC binding and spindle associated 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:38,029,869...38,063,773
Ensembl chr 6:38,029,864...38,063,859
G
SHISA3
shisa family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:33,373,633...33,379,039
Ensembl chr 8:33,374,265...33,378,951
G
SIGLEC5
sialic acid binding Ig like lectin 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:58,365,066...58,387,138
G
SIRT1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:26435214
NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297
G
SKAP2
src kinase associated phosphoprotein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:45,636,929...45,813,748
Ensembl chr18:45,637,360...45,790,259
G
SKIL
SKI like proto-oncogene
ISO
RGD
PMID:19189315
RGD:2308901
NCBI chr13:109,029,831...109,059,176
Ensembl chr13:109,029,952...109,059,173
G
SLA
Src like adaptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:8,166,829...8,247,396
Ensembl chr 4:8,189,232...8,247,388
G
SLA-7
MHC class I antigen 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:23,634,731...23,638,722
G
SLA-8
MHC class I antigen 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:23,622,352...23,625,818
G
SLA-DMA
SLA-DM alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:25,133,494...25,137,928
Ensembl chr 7:25,133,497...25,137,966
G
SLA-DMB
MHC class II, DM beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:25,119,278...25,125,089
Ensembl chr 7:25,119,282...25,128,236
G
SLA-DRA
MHC class II DR-alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:24,825,037...24,830,650
Ensembl chr 7:24,825,052...24,835,158
G
SLAMF9
SLAM family member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:90,535,348...90,538,495
Ensembl chr 4:90,535,582...90,538,456
G
SLC10A1
solute carrier family 10 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 7:93,400,037...93,421,989
Ensembl chr 7:93,397,608...93,421,985
G
SLC12A3
solute carrier family 12 member 3
ISO
protein:altered expression:kidney (rat)
RGD
PMID:15956070
RGD:1580587
NCBI chr 6:18,844,752...18,885,497
Ensembl chr 6:18,844,600...18,885,476
G
SLC15A3
solute carrier family 15 member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:10,799,927...10,814,363
Ensembl chr 2:10,800,503...10,814,389
G
SLC17A1
solute carrier family 17 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980 PMID:25380136
NCBI chr 7:20,522,650...20,589,037
Ensembl chr 7:20,523,022...20,574,460
G
SLC17A2
solute carrier family 17 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:20,596,547...20,663,498
Ensembl chr 7:20,644,244...20,663,423
G
SLC19A2
solute carrier family 19 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:81,510,221...81,535,099
Ensembl chr 4:81,510,098...81,536,464
G
SLC20A1
solute carrier family 20 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:43,844,716...43,860,547
Ensembl chr 3:43,844,722...43,860,547
G
SLC22A23
solute carrier family 22 member 23
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:1,988,690...2,131,778
Ensembl chr 7:1,988,696...2,131,908
G
SLC22A8
solute carrier family 22 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:8,782,030...8,800,998
Ensembl chr 2:8,782,060...8,800,997
G
SLC23A1
solute carrier family 23 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:141,258,318...141,277,555
Ensembl chr 2:141,258,323...141,276,442
G
SLC25A13
solute carrier family 25 member 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:75,781,421...75,980,606
Ensembl chr 9:75,781,361...75,980,518
G
SLC25A24
solute carrier family 25 member 24
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:111,580,186...111,632,390
Ensembl chr 4:111,579,663...111,634,266
G
SLC25A30
solute carrier family 25 member 30
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:21,848,242...21,872,781
Ensembl chr11:21,848,941...21,865,590
G
SLC25A4
solute carrier family 25 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:46,193,498...46,197,989
Ensembl chr15:46,193,746...46,200,987
G
SLC37A4
solute carrier family 37 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 9:46,247,278...46,254,068
Ensembl chr 9:46,247,282...46,254,031
G
SLC39A6
solute carrier family 39 member 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:119,861,853...119,885,836
Ensembl chr 6:119,861,846...119,885,378
G
SLC39A8
solute carrier family 39 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:118,604,852...118,678,115
Ensembl chr 8:118,605,402...118,678,107
G
SLC43A2
solute carrier family 43 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:47,791,911...47,839,127
Ensembl chr12:47,791,913...47,839,012
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SLC44A2
solute carrier family 44 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:69,364,946...69,399,081
Ensembl chr 2:69,365,012...69,399,081
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SLC46A1
solute carrier family 46 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:44,677,499...44,686,277
Ensembl chr12:44,677,502...44,686,250
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SLC4A4
solute carrier family 4 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:67,768,955...68,177,213
Ensembl chr 8:67,706,874...68,177,212
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SLC66A3
solute carrier family 66 member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:125,494,793...125,507,235
Ensembl chr 3:125,494,793...125,507,239
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SLC7A1
solute carrier family 7 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:6,538,053...6,604,654
Ensembl chr11:6,538,045...6,604,658
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SMAD1
SMAD family member 1
ISO
RGD
PMID:16447265
RGD:1643229
NCBI chr 8:82,907,557...82,987,909
Ensembl chr 8:82,908,527...82,968,994
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SMAD2
SMAD family member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16570350
NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357
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SMAD3
SMAD family member 3
treatment
ISO
RGD
PMID:30346985
RGD:151665755
NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449
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SMAD4
SMAD family member 4
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16570350 PMID:19824107
RGD:12903949
NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029
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SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:30,409,979...30,576,270
Ensembl chr13:30,409,983...30,576,327
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SMC2
structural maintenance of chromosomes 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:245,409,559...245,459,032
Ensembl chr 1:245,410,147...245,475,929
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SMC5
structural maintenance of chromosomes 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:223,560,271...223,653,370
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SMOC1
SPARC related modular calcium binding 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:93,480,064...93,628,332
Ensembl chr 7:93,480,159...93,628,328
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SMOC2
SPARC related modular calcium binding 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:1,193,163...1,332,739
Ensembl chr 1:1,193,167...1,332,694
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SNAP23
synaptosome associated protein 23
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:128,849,465...128,888,972
Ensembl chr 1:128,847,931...128,888,947
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SNAP29
synaptosome associated protein 29
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:50,492,187...50,511,475
Ensembl chr14:50,492,187...50,511,456
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SNX7
sorting nexin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:119,040,986...119,258,507
Ensembl chr 4:119,035,133...119,255,877
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SOAT1
sterol O-acyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:121,045,211...121,112,393
Ensembl chr 9:121,045,234...121,113,692
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SOCS1
suppressor of cytokine signaling 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15197228
NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967
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SOX4
SRY-box transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:16,886,834...16,895,488
Ensembl chr 7:16,891,319...16,892,752
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SP140
SP140 nuclear body protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:131,225,305...131,292,172
Ensembl chr15:131,226,626...131,292,170
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SPARC
secreted protein acidic and cysteine rich
ISO
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:increased expression:liver, fat cell
RGD CTD
PMID:8786698 PMID:18615449 PMID:25380136
RGD:2300030 RGD:2300071
NCBI chr16:71,368,164...71,380,972
Ensembl chr16:71,357,586...71,381,161
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SPP1
secreted phosphoprotein 1
ISO
RGD
PMID:16221502
RGD:1581332
NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
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SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:81,849,908...81,926,764
Ensembl chr13:81,867,740...81,926,762
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SPTAN1
spectrin alpha, non-erythrocytic 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:268,936,120...269,002,261
Ensembl chr 1:268,936,025...269,002,256
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SRD5A1
steroid 5 alpha-reductase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:75,309,830...75,335,438
Ensembl chr16:75,310,211...75,335,391
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SREBF1
sterol regulatory element binding transcription factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267
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SRGN
serglycin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:72,183,368...72,199,262
Ensembl chr14:72,183,363...72,199,250
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SRI
sorcin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:68,492,235...68,515,247
Ensembl chr 9:68,490,890...68,515,322
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ST14
ST14 transmembrane serine protease matriptase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:56,888,246...56,929,771
Ensembl chr 9:56,888,246...56,929,767
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STAC3
SH3 and cysteine rich domain 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:22,549,008...22,556,330
Ensembl chr 5:22,549,010...22,719,054
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STARD13
StAR related lipid transfer domain containing 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:9,518,135...9,738,370
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STAT3
signal transducer and activator of transcription 3
treatment
ISO
RGD
PMID:30346985
RGD:151665755
NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992
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STAT5A
signal transducer and activator of transcription 5A
treatment
ISO
RGD
PMID:30346985
RGD:151665755
NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138
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STAU2
staufen double-stranded RNA binding protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:62,139,456...62,455,509
Ensembl chr 4:62,139,464...62,455,499
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STEAP4
STEAP4 metalloreductase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:68,549,142...68,570,350
Ensembl chr 9:68,546,465...68,570,424
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STK10
serine/threonine kinase 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr16:52,003,768...52,140,378
Ensembl chr16:52,003,887...52,140,367
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SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 8:66,811,536...66,838,181
Ensembl chr 8:66,811,550...66,834,473
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SULT2A1
sulfotransferase family 2A member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17072980
NCBI chr 6:53,525,496...53,536,723
Ensembl chr 6:53,524,787...53,536,718
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SYNRG
synergin gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:38,974,567...39,069,868
Ensembl chr12:38,975,916...39,069,798
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TAGLN2
transgelin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:90,566,272...90,574,762
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TAP2
transporter 2, ATP binding cassette subfamily B member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:25,045,085...25,056,915
Ensembl chr 7:25,043,840...25,056,922
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TAX1BP3
Tax1 binding protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:49,754,162...49,759,026
Ensembl chr12:49,754,166...49,759,412
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TBC1D9
TBC1 domain family member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:86,402,745...86,518,182
Ensembl chr 8:86,402,839...86,517,764
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TCF20
transcription factor 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:6,430,217...6,534,948
Ensembl chr 5:6,484,365...6,528,172
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TCF4
transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:104,718,809...105,079,919
Ensembl chr 1:104,719,151...105,079,919
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TERT
telomerase reverse transcriptase
ISO
protein:increased expression, increased localization:nucleus
RGD
PMID:20353272
RGD:11038673
NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421
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TES
testin LIM domain protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:29,895,878...29,936,248
Ensembl chr18:29,895,882...29,936,233
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TF
transferrin
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15650968 PMID:22464783
RGD:7244387
NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,972,763
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TFEC
transcription factor EC
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:29,980,394...30,260,226
Ensembl chr18:30,122,494...30,175,484
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TFPI2
tissue factor pathway inhibitor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:73,684,236...73,694,663
Ensembl chr 9:73,673,535...73,689,095
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TGFB1
transforming growth factor beta 1
treatment onset
ISO
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:increased expression:liver (mouse) associated with Chemical and Drug Induced Liver Injury protein:increased expression:liver associated with extrahepatic cholestasis
CTD RGD
PMID:12586293 PMID:15772939 PMID:16009107 PMID:16579972 PMID:26806094 PMID:27528511 PMID:27605418 PMID:28390311 PMID:28465467 PMID:30092114 PMID:30243650 More...
RGD:14985231 RGD:14985232 RGD:14985234 RGD:14995475 RGD:1601595 RGD:39939037
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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TGFB3
transforming growth factor beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:99,133,873...99,162,239
Ensembl chr 7:99,133,879...99,162,232
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TGFBR1
transforming growth factor beta receptor 1
ISO
protein:increased expression:liver
RGD
PMID:15723089 PMID:16009107
RGD:1601595 RGD:2302027
NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,860,156...240,918,528
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TGFBR2
transforming growth factor beta receptor 2
treatment
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:15942678 PMID:16627068 PMID:30346985
RGD:151665755 RGD:1579923
NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160
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TH
tyrosine hydroxylase
ISO
mRNA:decreased expression:superior mesenteric artery (rat)
RGD
PMID:18457899
RGD:5129683
NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,620...1,506,170
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THBD
thrombomodulin
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:liver
CTD RGD
PMID:21112949 PMID:25380136
RGD:5685038
NCBI chr17:30,219,870...30,223,499
Ensembl chr17:30,217,303...30,224,099
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THPO
thrombopoietin
ISO
mRNA:decreased expression:liver
RGD
PMID:9794189
RGD:1580082
NCBI chr13:122,259,654...122,267,860
Ensembl chr13:122,260,215...122,267,860
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THYN1
thymocyte nuclear protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:60,802,925...60,807,404
Ensembl chr 9:60,802,928...60,807,409
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TIAL1
TIA1 cytotoxic granule associated RNA binding protein like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:129,441,209...129,467,150
Ensembl chr14:129,441,211...129,467,112
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TIMP1
TIMP metallopeptidase inhibitor 1
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver
CTD RGD
PMID:8707259 PMID:16507762 PMID:16718785 PMID:16762003 PMID:21163135 PMID:25380136 More...
RGD:2290364
NCBI chr X:42,103,251...42,106,289
Ensembl chr X:42,102,172...42,106,296
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TIMP2
TIMP metallopeptidase inhibitor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,834
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TKFC
triokinase and FMN cyclase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:10,158,183...10,171,452
Ensembl chr 2:10,158,188...10,171,449
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TLR2
toll like receptor 2
treatment
ISO
RGD
PMID:22683883 PMID:27601294
RGD:18182936 RGD:7241092
NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330
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TLR3
toll like receptor 3
ISO
RGD
PMID:27178735
RGD:21079415
NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291
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TLR4
toll like receptor 4
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:22683883 PMID:25380136 PMID:27601294
RGD:18182936 RGD:7241092
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
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TM6SF1
transmembrane 6 superfamily member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:51,815,109...51,844,938
Ensembl chr 7:51,815,530...51,845,163
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TMBIM1
transmembrane BAX inhibitor motif containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:120,348,740...120,365,055
Ensembl chr15:120,348,735...120,365,007
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TMEM106A
transmembrane protein 106A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:19,747,346...19,755,586
Ensembl chr12:19,745,782...19,755,521
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TMEM165
transmembrane protein 165
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 8:54,751,570...54,796,352
Ensembl chr 8:54,751,572...54,787,886
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TMEM178A
transmembrane protein 178A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:100,613,878...100,887,023
Ensembl chr 3:100,613,881...100,669,651
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TMEM184B
transmembrane protein 184B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:9,633,554...9,682,116
Ensembl chr 5:9,633,554...9,682,115
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TMEM43
transmembrane protein 43
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:70,397,069...70,417,213
Ensembl chr13:70,393,227...70,417,168
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TMEM65
transmembrane protein 65
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:15,263,400...15,317,350
Ensembl chr 4:15,263,745...15,352,225
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TMSB10
thymosin beta 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:59,776,236...59,777,252
Ensembl chr 3:59,776,236...59,777,252
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TNF
tumor necrosis factor
treatment
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver (mouse)
CTD RGD
PMID:16085334 PMID:24383550 PMID:28465467
RGD:10450610 RGD:39939037
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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TNFAIP8
TNF alpha induced protein 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:123,152,349...123,285,154
Ensembl chr 2:123,152,371...123,287,941
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TNFRSF12A
TNF receptor superfamily member 12A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:39,166,288...39,168,294
Ensembl chr 3:39,166,298...39,168,302
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TOR4A
torsin family 4 member A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
G
TPM1
tropomyosin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:108,986,981...109,016,090
Ensembl chr 1:108,986,986...109,020,035
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TPM3
tropomyosin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:95,542,329...95,572,946
Ensembl chr 4:95,542,473...95,572,938
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TPM4
tropomyosin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:61,453,721...61,476,781
Ensembl chr 2:61,453,725...61,476,781
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TRAFD1
TRAF-type zinc finger domain containing 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:39,549,849...39,579,781
Ensembl chr14:39,549,851...39,579,781
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TRAK2
trafficking kinesin protein 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:104,991,261...105,056,054
Ensembl chr15:104,991,726...105,055,025
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TRIB3
tribbles pseudokinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:34,808,273...34,819,592
Ensembl chr17:34,807,582...34,816,451
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TRIM24
tripartite motif containing 24
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:11,055,211...11,151,755
Ensembl chr18:11,055,213...11,151,404
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TRIM59
tripartite motif containing 59
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:100,118,824...100,133,117
Ensembl chr13:100,118,826...100,132,967
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TRPV1
transient receptor potential cation channel subfamily V member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17043671
NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977
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TSC22D1
TSC22 domain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr11:22,518,792...22,634,411
Ensembl chr11:22,518,795...22,634,407
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TSPAN8
tetraspanin 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:35,210,744...35,482,788
Ensembl chr 5:35,240,715...35,321,845
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TSPO
translocator protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 5:5,723,190...5,735,097
Ensembl chr 5:5,723,190...5,735,131
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TSTD3
thiosulfate sulfurtransferase like domain containing 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:66,459,042...66,467,856
G
TTC36
tetratricopeptide repeat domain 36
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 9:45,829,014...45,838,978
Ensembl chr 9:45,829,191...45,838,979
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TUBB6
tubulin beta 6 class V
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:97,233,639...97,240,692
Ensembl chr 6:97,229,868...97,240,662
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TUSC3
tumor suppressor candidate 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:3,312,684...3,507,372
Ensembl chr17:3,312,741...3,507,729
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TYROBP
transmembrane immune signaling adaptor TYROBP
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,201...45,312,539
G
U2SURP
U2 snRNP associated SURP domain containing
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:83,704,501...83,759,800
Ensembl chr13:83,704,587...83,759,971
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UBD
ubiquitin D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:22,501,130...22,502,883
Ensembl chr 7:22,500,601...22,515,602
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UGCG
UDP-glucose ceramide glucosyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:252,651,850...252,690,817
Ensembl chr 1:252,651,879...252,688,550
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UNC5CL
unc-5 family C-terminal like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 7:36,332,183...36,347,409
Ensembl chr 7:36,332,201...36,347,175
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UNC93B1
unc-93 homolog B1, TLR signaling regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:4,898,414...4,909,833
Ensembl chr 2:4,898,409...4,909,856
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VASP
vasodilator stimulated phosphoprotein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:51,872,810...51,886,729
Ensembl chr 6:51,872,812...51,886,724
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VAV1
vav guanine nucleotide exchange factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:72,327,433...72,391,649
Ensembl chr 2:72,326,716...72,391,648
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VEGFA
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:18416461 PMID:18458672
NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
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VIM
vimentin
ISO
CTD Direct Evidence: marker/mechanism associated with Schistosomiasis Japonica; mRNA:increased expression:liver (rat)
CTD RGD
PMID:25380136 PMID:29323718
RGD:38599216
NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,170
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VIPR1
vasoactive intestinal peptide receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr13:26,036,610...26,073,168
Ensembl chr13:26,036,629...26,075,691
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VOPP1
VOPP1 WW domain binding protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr18:48,607,923...48,693,858
Ensembl chr18:48,607,919...48,693,815
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VSIR
V-set immunoregulatory receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr14:74,667,081...74,693,347
Ensembl chr14:74,666,624...74,693,281
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VWF
von Willebrand factor
ISO
protein:increased expression:liver: CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:7531171 PMID:28527913
RGD:11079232
NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,517,555...64,655,938
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WFDC2
WAP four-disulfide core domain 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:47,816,452...47,824,087
Ensembl chr17:47,816,452...47,824,087
G
WIPF1
WAS/WASL interacting protein family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:80,521,032...80,646,462
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WLS
Wnt ligand secretion mediator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 6:144,242,639...144,529,659
Ensembl chr 6:144,399,926...144,555,880
G
XPNPEP2
X-prolyl aminopeptidase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr X:106,333,785...106,363,412
Ensembl chr X:106,333,825...106,362,187
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YBX1
Y-box binding protein 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16012952
NCBI chr 6:168,716,782...168,736,475
Ensembl chr 6:168,716,772...168,736,604
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YPEL3
yippee like 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:18,277,999...18,281,342
Ensembl chr 3:18,278,002...18,281,298
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YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 3:9,994,802...10,023,296
Ensembl chr 3:9,994,836...10,023,289
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YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 4:35,975,513...36,009,909
Ensembl chr 4:35,975,508...36,009,887
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ZBTB4
zinc finger and BTB domain containing 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr12:52,759,912...52,775,725
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ZDHHC13
zinc finger DHHC-type palmitoyltransferase 13
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:40,251,511...40,310,455
Ensembl chr 2:40,251,246...40,310,455
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ZDHHC2
zinc finger DHHC-type palmitoyltransferase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr17:4,855,129...4,928,109
Ensembl chr17:4,855,345...4,928,664
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ZEB2
zinc finger E-box binding homeobox 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr15:7,498,879...7,631,347
Ensembl chr15:7,499,026...7,632,655
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ZFP37
ZFP37 zinc finger protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 1:253,702,590...253,742,614
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ZFYVE16
zinc finger FYVE-type containing 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25380136
NCBI chr 2:89,044,860...89,109,237
Ensembl chr 2:89,045,362...89,106,975
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KRT18
keratin 18
susceptibility
ISO
ClinVar Annotator: match by term: Cirrhosis, familial | ClinVar Annotator: match by term: Cirrhosis, noncryptogenic, susceptibility to
ClinVar OMIM
PMID:9011570 PMID:12724528 PMID:25741868
NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429
G
KRT8
keratin 8
ISO
ClinVar Annotator: match by term: Cirrhosis, familial | ClinVar Annotator: match by term: Cirrhosis, noncryptogenic, susceptibility to
ClinVar
PMID:9011570 PMID:12724528 PMID:25741868
NCBI chr 5:18,172,423...18,180,277
Ensembl chr 5:18,167,553...18,180,404
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TJP2
tight junction protein 2
ISO
ClinVar Annotator: match by term: Familial primary biliary cirrhosis
ClinVar
PMID:25741868 PMID:28492532 PMID:32439973
NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
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TULP3
TUB like protein 3
ISO
ClinVar Annotator: match by term: Hepatorenocardiac degenerative fibrosis
OMIM ClinVar
PMID:25741868 PMID:35397207
NCBI chr 5:67,201,680...67,238,348
Ensembl chr 5:67,199,448...67,238,322
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SLC30A10
solute carrier family 30 member 10
ISO
ClinVar Annotator: match by term: Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, and Chronic Liver Disease | ClinVar Annotator: match by term: Hypermanganesemia with dystonia 1 | ClinVar Annotator: match by term: Hypermanganesemia with dystonia, polycythemia, and cirrhosis
OMIM ClinVar
PMID:11040156 PMID:18392750 PMID:22341971 PMID:22341972 PMID:22934317 PMID:25741868 PMID:27117033 PMID:28492532 PMID:30272946 PMID:31594250 PMID:34315874 More...
NCBI chr10:9,527,523...9,545,493
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UTP4
UTP4 small subunit processome component
ISO
ClinVar Annotator: match by term: Hereditary North American Indian childhood cirrhosis
ClinVar
PMID:9536098 PMID:12417987 PMID:16225863 PMID:17576681 PMID:19732766 PMID:20385600 PMID:22916032 PMID:24123366 PMID:25741868 PMID:27535533 PMID:28492532 More...
NCBI chr 6:17,784,908...17,818,417
Ensembl chr 6:17,778,556...17,818,132
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ABCA1
ATP binding cassette subfamily A member 1
ISO
mRNA:increased expression:liver (human)
RGD
PMID:28660384
RGD:21203516
NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
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ABCB4
ATP binding cassette subfamily B member 4
treatment disease_progression
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs, haplotype, diplotype: : rs31658, rs31672,rs1149222(human)
CTD RGD
PMID:18671305 PMID:20040336 PMID:21209952 PMID:30682444
RGD:14694982 RGD:153297773
NCBI chr 9:93,171,371...93,262,124
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ABCC2
ATP binding cassette subfamily C member 2
ISO
CTD Direct Evidence: marker/mechanism protein:decreased expression:liver
CTD RGD
PMID:15542527 PMID:15770136
RGD:14700810
NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,582...111,038,898
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ABCG2A
ATP binding cassette subfamily G member 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15542527
NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,775,444...130,945,393
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ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
ISO
mRNA:increased expression:liver
RGD
PMID:19389807
RGD:2325226
NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703
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ACE2
angiotensin converting enzyme 2
ISO
mRNA, protein:increased expression:liver
RGD
PMID:17532087
RGD:9685452
NCBI chr X:12,099,849...12,152,204
Ensembl chr X:12,093,242...12,151,286
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AGT
angiotensinogen
ISO
protein:increased expression:plasma
RGD
PMID:17532087
RGD:9685452
NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
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ALB
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30026087
NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
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AQP4
aquaporin 4
ISO
RGD
PMID:20451280
RGD:5148030
NCBI chr 6:111,407,632...111,422,169
Ensembl chr 6:111,407,639...111,422,109
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CA1
carbonic anhydrase 1
ISO
RGD
PMID:12806141
RGD:408425977
NCBI chr 4:51,343,548...51,353,127
Ensembl chr 4:51,302,406...51,353,126
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CA2
carbonic anhydrase 2
ISO
RGD
PMID:12806141
RGD:408425977
NCBI chr 4:51,194,686...51,211,436
Ensembl chr 4:51,193,756...51,211,259
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CCL5
C-C motif chemokine ligand 5
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:liver:
CTD RGD
PMID:12126966 PMID:15770052
RGD:14995336
NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
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CCN2
cellular communication network factor 2
ISO
mRNA:increased expression:liver (rat)
RGD
PMID:19371232
RGD:2314517
NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691
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CD14
CD14 molecule
disease_progression
ISO
protein:increased expression:liver (human)
RGD
PMID:21275501
RGD:407420272
NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581
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CD3D
CD3 delta subunit of T-cell receptor complex
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 9:45,640,475...45,644,153
Ensembl chr 9:45,637,129...45,644,221
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CD68
CD68 molecule
disease_progression
ISO
protein:increased expression:liver (human)
RGD
PMID:21275501
RGD:407420272
NCBI chr12:52,874,754...52,877,256
Ensembl chr12:52,874,785...52,877,695
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CD80
CD80 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr13:140,693,312...140,730,541
Ensembl chr13:140,693,382...140,728,976
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CDH5
cadherin 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177
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CDKN1A
cyclin dependent kinase inhibitor 1A
ISO
protein:increased expression:epithelial cell:
RGD
PMID:18456456
RGD:8662434
NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761
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CENPB
centromere protein B
ISO
RGD
PMID:8911074
RGD:27226708
NCBI chr17:31,929,846...31,932,539
Ensembl chr17:31,929,892...31,931,712
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CLEC16A
C-type lectin domain containing 16A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr 3:31,938,133...32,158,343
Ensembl chr 3:31,938,135...32,158,320
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COL1A1
collagen type I alpha 1 chain
treatment
ISO
RGD
PMID:20056896
RGD:8552731
NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,004
G
CPEB1
cytoplasmic polyadenylation element binding protein 1
ISO
protein:increased expression:liver
RGD
PMID:26627607
RGD:11528851
NCBI chr 7:52,329,054...52,382,408
Ensembl chr 7:52,304,472...52,383,732
G
CPEB4
cytoplasmic polyadenylation element binding protein 4
ISO
protein:increased expression:liver
RGD
PMID:26627607
RGD:11528851
NCBI chr16:50,430,345...50,499,086
Ensembl chr16:50,430,348...50,498,938
G
CTLA4
cytotoxic T-lymphocyte associated protein 4
no_association susceptibility disease_progression
ISO
DNA:SNP:CDS:49A>G(human) DNA:SNP:CDS:60G>A(rs3087243)(human) DNA:SNPs: :rs231775, rs3087243, rs231725 (human) autoimmune biliary cirrhosis; DNA:SNP:CDS:49A>G, significant association with G allele (p<0.0002)
RGD
PMID:10782900 PMID:16584111 PMID:17482523 PMID:21594562
RGD:14398725 RGD:14398743 RGD:14398744 RGD:2301998
NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103
G
CXCL10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
G
CXCL8
C-X-C motif chemokine ligand 8
ISO
mRNA:increased expression:liver (human)
RGD
PMID:21731723
RGD:26884357
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
G
CXCL9
C-X-C motif chemokine ligand 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271
G
CXCR5
C-X-C motif chemokine receptor 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr 9:46,134,243...46,146,638
Ensembl chr 9:46,143,117...46,146,636
G
CYGB
cytoglobin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30026087
NCBI chr12:4,977,245...4,988,283
G
DAG1
dystroglycan 1
ISO
mRNA:increased expression:liver
RGD
PMID:12177244
RGD:2314895
NCBI chr13:32,028,019...32,092,450
Ensembl chr13:32,029,522...32,092,450
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DENND1B
DENN domain containing 1B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr10:20,391,507...20,635,808
Ensembl chr10:20,395,481...20,635,748
G
DNASE1
deoxyribonuclease 1
ISO
protein:decreased activity:serum (human)
RGD
PMID:28263100
RGD:38500241
NCBI chr 3:38,590,045...38,646,852
Ensembl chr 3:38,586,602...38,646,833
G
ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:15651265
RGD:9685530
G
FAS
Fas cell surface death receptor
ISO
protein:increased expression:lymphocyte:
RGD
PMID:26429926
RGD:14700711
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
G
FOXP3
forkhead box P3
ISO
mRNA:increased expression:liver
RGD
PMID:17158635
RGD:38501106
NCBI chr X:43,303,777...43,328,164
Ensembl chr X:43,303,785...43,322,968
G
GCH1
GTP cyclohydrolase 1
treatment
ISO
RGD
PMID:20132096
RGD:329970291
NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,199,679...184,257,315
G
HAMP
hepcidin antimicrobial peptide
treatment
ISO
mRNA:decreased expression:liver
RGD
PMID:19652645 PMID:23704825
RGD:11041639 RGD:11041732
NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,160...44,787,305
G
HHIP
hedgehog interacting protein
ISO
mRNA:decreased expression:
RGD
PMID:18375471
RGD:11552599
NCBI chr 8:83,583,735...83,678,368
Ensembl chr 8:83,583,739...83,679,136
G
HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22271822
NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
G
HMOX1
heme oxygenase 1
ISO
mRNA, protein:increased expression:liver, lung
RGD
PMID:12114196
RGD:625603
G
ICAM1
intercellular adhesion molecule 1
treatment
ISO
associated with Graft vs Host Disease;
RGD
PMID:10051478
RGD:11520783
NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
G
ICAM3
intercellular adhesion molecule 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 2:69,143,063...69,150,221
Ensembl chr 2:69,143,062...69,150,225
G
IFNG
interferon gamma
ISO
mRNA:increased expression:liver
RGD
PMID:17158635
RGD:38501106
NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
G
IGFBP1
insulin like growth factor binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr18:50,018,487...50,022,799
Ensembl chr18:50,018,487...50,022,799
G
IL10
interleukin 10
ISO
mRNA:increased expression:liver
RGD
PMID:17158635
RGD:38501106
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
G
IL12A
interleukin 12A
susceptibility treatment
ISO
DNA:SNPs, haplotype: :rs6441286, rs574808(human) CTD Direct Evidence: marker/mechanism DNA:SNPs:enhancer:rs4679868, rs6441286, rs666251(human) DNA:SNP: :rs62270414(human)
RGD CTD
PMID:19458352 PMID:20639880 PMID:23433321 PMID:27175695
RGD:25440489 RGD:25440498 RGD:25440500
NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078
G
IL12B
interleukin 12B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20639880
NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929
G
IL12RB1
interleukin 12 receptor subunit beta 1
susceptibility
ISO
RNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:23910013
RGD:14700865
NCBI chr 2:59,707,958...59,736,282
Ensembl chr 2:59,707,961...59,736,282
G
IL4
interleukin 4
treatment
ISO
RGD
PMID:20442198
RGD:7829828
NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
G
IL6
interleukin 6
disease_progression
ISO
protein:increased expression:blood serum (human)
RGD
PMID:21275501
RGD:407420272
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
IL7R
interleukin 7 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr16:21,300,141...21,330,156
Ensembl chr16:21,300,111...21,329,585
G
JAK2
Janus kinase 2
treatment
ISO
RGD
PMID:24619965
RGD:10403061
NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148
G
KEAP1
kelch like ECH associated protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30026087
NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382
G
KRT18
keratin 18
severity
ISO
protein:increased expression:serum (human)
RGD
PMID:26110613
RGD:18337483
NCBI chr 5:18,217,686...18,221,432
Ensembl chr 5:18,217,691...18,221,429
G
KRT7
keratin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21681009
NCBI chr 5:17,553,192...17,570,582
Ensembl chr 5:17,555,728...17,570,581
G
LBR
lamin B receptor
ISO
RGD
PMID:8550049
RGD:9588625
NCBI chr10:13,389,896...13,416,831
Ensembl chr10:13,386,946...13,416,759
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LEP
leptin
ISO
protein:decreased expression:serum:
RGD
PMID:16093869
RGD:10411894
NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323
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LEPR
leptin receptor
ISO
protein:increased expression:blood serum
RGD
PMID:16093869
RGD:10411894
NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995
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LOC110258578
interleukin-1 beta-like
disease_progression
ISO
protein:increased expression:blood serum (human)
RGD
PMID:21275501
RGD:407420272
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LOX
lysyl oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16023247
NCBI chr 2:125,595,115...125,607,026
Ensembl chr 2:125,591,789...125,607,594
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LOXL2
lysyl oxidase like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16023247
NCBI chr14:7,435,861...7,540,699
Ensembl chr14:7,435,867...7,540,704
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MAP3K14
mitogen-activated protein kinase kinase kinase 14
ISO
OMIM:109720 | OMIM:613007 | OMIM:613008 | OMIM:614220 | OMIM:614221
MouseDO
NCBI chr12:18,142,899...18,182,931
Ensembl chr12:18,142,952...18,182,928
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MAPK14
mitogen-activated protein kinase 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30026087
NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031
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MAS1
MAS1 proto-oncogene, G protein-coupled receptor
ISO
RGD
PMID:17532087
RGD:9685452
NCBI chr 1:7,527,566...7,542,110
Ensembl chr 1:7,527,861...7,528,838
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MET
MET proto-oncogene, receptor tyrosine kinase
severity
ISO
RGD
PMID:19208365
RGD:14694826
NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512
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MIR21
microRNA mir-21
severity
ISO
RGD
PMID:28886078
RGD:21408577
NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
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MMEL1
membrane metalloendopeptidase like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20639879
NCBI chr 6:64,436,778...64,470,888
Ensembl chr 6:64,436,642...64,472,759
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MMP13
matrix metallopeptidase 13
treatment
ISO
RGD
PMID:20056896
RGD:8552731
NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162
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MMP2
matrix metallopeptidase 2
treatment
ISO
RGD
PMID:20056896
RGD:8552731
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
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MMP9
matrix metallopeptidase 9
treatment
ISO
RGD
PMID:20056896
RGD:8552731
NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
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MUC2
mucin 2, oligomeric mucus/gel-forming
ISO
RGD
PMID:18507686
RGD:2324885
NCBI chr 2:689,363...719,542
Ensembl chr 2:689,364...710,330
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NFE2L2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30026087
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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NFKB1
nuclear factor kappa B subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
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NOS2
nitric oxide synthase 2
ISO
protein:increased expression, increased activity:brain (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21903766 PMID:30026087
RGD:5509055
NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
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NOS3
nitric oxide synthase 3
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20132096 PMID:30026087
RGD:329970291
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
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NR1H4
nuclear receptor subfamily 1 group H member 4
susceptibility
ISO
mRNA,protein:decreased expression:liver (human)
RGD
PMID:29968724
RGD:14928336
NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604
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NR3C1
nuclear receptor subfamily 3 group C member 1
ISO
mRNA:altered expression:leukocyte, mononuclear
RGD
PMID:15635817
RGD:4892607
NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451
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NSA2
NSA2 ribosome biogenesis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 2:83,843,893...83,851,232
Ensembl chr 2:83,843,898...83,852,212
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NUP62
nucleoporin 62
severity
ISO
RGD
PMID:12753810
RGD:9831196
NCBI chr 6:54,921,627...54,945,705
Ensembl chr 6:54,921,627...54,923,227
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PDE5A
phosphodiesterase 5A
ISO
RGD
PMID:17610866
RGD:2314466
NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953
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PPARGC1A
PPARG coactivator 1 alpha
ISO
mRNA, protein:decreased expression:liver
RGD
NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,946,992
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RELA
RELA proto-oncogene, NF-kB subunit
disease_progression
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:liver (human)
CTD RGD
PMID:21275501 PMID:30026087
RGD:407420272
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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REN
renin
ISO
protein:increased activity:plasma (rat)
RGD
PMID:22266601
RGD:6892690
NCBI chr 9:64,809,143...64,822,605
Ensembl chr 9:64,809,146...64,822,658
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RPS6KB1
ribosomal protein S6 kinase B1
ISO
protein:increased expression, increased phosphorylation:liver
RGD
PMID:15769867
RGD:1642977
NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376
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SLC4A2
solute carrier family 4 member 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18188457
NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212
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SLC51A
solute carrier family 51 member A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16423920
NCBI chr13:133,851,775...133,869,753
Ensembl chr13:133,851,776...133,869,753
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SLC51B
SLC51 subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16423920
NCBI chr 1:163,081,145...163,089,491
Ensembl chr 1:163,081,180...163,089,488
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SLCO1C1
solute carrier organic anion transporter family member 1C1
ISO
protein:decreased expression:liver
RGD
PMID:15770136
RGD:14700810
NCBI chr 5:52,234,396...52,315,311
Ensembl chr 5:52,234,398...52,315,026
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SOD2
superoxide dismutase 2
ISO
protein:increased expression:serum
RGD
PMID:1682406
RGD:2317411
NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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SPIB
Spi-B transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20639880
NCBI chr 6:55,272,847...55,280,881
Ensembl chr 6:55,272,890...55,280,874
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SPINT1
serine peptidase inhibitor, Kunitz type 1
ISO
mRNA:increased expression:liver:
RGD
PMID:21898507
RGD:10043111
NCBI chr 1:130,458,909...130,473,791
Ensembl chr 1:130,458,909...130,473,783
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SPINT2
serine peptidase inhibitor, Kunitz type 2
ISO
mRNA:increased expression:liver:
RGD
PMID:21898507
RGD:10043111
NCBI chr 6:47,181,772...47,210,564
Ensembl chr 6:47,181,768...47,210,559
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STAT4
signal transducer and activator of transcription 4
no_association susceptibility
ISO
DNA:SNPs:3'utr: (rs7574865, rs8179673, rs10181656) (human) CTD Direct Evidence: marker/mechanism DNA:SNPs, haplotypes:multiple DNA:SNP: intron: (rs7574865) (human) associated with Crohn���s disease; DNA:SNP:intron: (rs7574865) (human)
RGD CTD
PMID:21399635 PMID:24648611 PMID:26084578 PMID:28395724
RGD:25671415 RGD:25671416 RGD:25671421
NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,656,077...95,763,472
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TGFB1
transforming growth factor beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30026087
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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TJP2
tight junction protein 2
ISO
ClinVar Annotator: match by term: Primary biliary cirrhosis
ClinVar
PMID:25741868 PMID:28492532 PMID:32439973
NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
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TLR9
toll like receptor 9
ISO
protein:increased expression:liver, peripheral blood mononuclear cell (human)
RGD
PMID:23026026
RGD:18337477
NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673
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TNF
tumor necrosis factor
disease_progression
ISO
protein:increased expression:serum (human) protein:increased expression:blood serum(human) mRNA:increased expression:liver
RGD
PMID:9047083 PMID:17158635 PMID:21275501
RGD:14995307 RGD:38501106 RGD:407420272
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21399635
NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909
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TYK2
tyrosine kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22961000
NCBI chr 2:69,157,774...69,183,555
Ensembl chr 2:69,157,811...69,183,456
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UBD
ubiquitin D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18422935
NCBI chr 7:22,501,130...22,502,883
Ensembl chr 7:22,500,601...22,515,602
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UTP4
UTP4 small subunit processome component
ISO
North American Indian childhood cirrhosis, OMIM:604901, R565W
RGD
PMID:12417987
RGD:1600653
NCBI chr 6:17,784,908...17,818,417
Ensembl chr 6:17,778,556...17,818,132
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VDR
vitamin D receptor
susceptibility
ISO
DNA:SNP: : DNA:polymorphism: :
RGD
PMID:15683428 PMID:19376604
RGD:14401750 RGD:14402024
NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475
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VEGFA
vascular endothelial growth factor A
ISO
protein:increased expression:liver protein:increased expression:plasma:
RGD
PMID:26615570 PMID:26627607
RGD:11528851 RGD:11538286
NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
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ZC3H12A
zinc finger CCCH-type containing 12A
ISO
OMIM:109720 | OMIM:613007 | OMIM:613008 | OMIM:614220 | OMIM:614221
MouseDO
NCBI chr 6:93,541,334...93,551,200
Ensembl chr 6:93,541,334...93,551,193
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IL12RB2
interleukin 12 receptor subunit beta 2
ISO
ClinVar Annotator: match by term: IL12RB2-related condition
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 6:145,210,251...145,292,399
Ensembl chr 6:145,212,981...145,281,791
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LBR
lamin B receptor
ISO
ClinVar Annotator: match by term: PRIMARY BILIARY CIRRHOSIS, SCLERODERMA, RAYNAUD DISEASE, AND TELANGIECTASIA | ClinVar Annotator: match by term: Reynolds syndrome
OMIM ClinVar
PMID:18382993 PMID:20522425 PMID:24033266 PMID:25348816 PMID:25741868 PMID:26467025 PMID:28492532 PMID:32827848 More...
NCBI chr10:13,389,896...13,416,831
Ensembl chr10:13,386,946...13,416,759
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