INPPL1 (inositol polyphosphate phosphatase like 1)

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Gene: INPPL1 (inositol polyphosphate phosphatase like 1) Sus scrofa

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Symbol:

INPPL1

Name:

inositol polyphosphate phosphatase like 1

RGD ID:

14178043

Description:

ENCODES a protein that exhibits inositol-polyphosphate 5-phosphatase activity (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN apoptotic process (ortholog); ERK1 and ERK2 cascade (ortholog); establishment of mitotic spindle orientation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); cerebral folate receptor alpha deficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN nuclear speck; nucleus; basal plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Inositol polyphosphate phosphatase-like protein 1; INPPL-1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; SHIP2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,793,069 - 6,808,028 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	6,793,971 - 6,807,286 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	7,554,374 - 7,570,176 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria type 7b (ISO)

cerebral folate receptor alpha deficiency (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hypertension (ISO)

hypoglycemia (ISO)

Insulin Resistance (ISO)

intellectual disability (ISO)

Metabolic Syndrome (ISO)

obesity (ISO)

Opsismodysplasia (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IEA)

apoptotic process (IEA,ISO)

endochondral ossification (IEA)

endocytosis (IEA)

ERK1 and ERK2 cascade (IEA,ISO)

establishment of mitotic spindle orientation (ISS)

gene expression (IEA,ISO)

glucose metabolic process (IEA,ISO)

immune system process (IEA)

inositol trisphosphate metabolic process (ISO)

lipid metabolic process (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of DNA replication (ISO)

negative regulation of gene expression (IEA,ISO)

negative regulation of insulin receptor signaling pathway (ISO)

negative regulation of insulin-like growth factor receptor signaling pathway (IBA,ISO)

negative regulation of MAP kinase activity (ISO)

negative regulation of neuron projection development (ISO)

negative regulation of platelet-derived growth factor receptor signaling pathway (ISO)

phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

phosphatidylinositol biosynthetic process (IEA,ISO)

phosphatidylinositol dephosphorylation (IEA)

post-embryonic development (IEA,ISO)

regulation of actin filament organization (ISS)

regulation of immune response (IBA)

regulation of protein localization (ISS)

response to insulin (IEA,ISO)

response to xenobiotic stimulus (ISO)

ruffle assembly (IEA,ISO)

Cellular Component

basal plasma membrane (IEA,ISS)

cell projection (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (IBA,IEA)

filopodium (IEA)

Golgi apparatus (IEA)

lamellipodium (IEA,ISO)

membrane (IEA)

nuclear speck (IDA,IEA)

nucleus (IDA,IEA)

plasma membrane (IEA)

spindle pole (IEA,ISS)

Molecular Function

hydrolase activity (IEA)

inositol-polyphosphate 5-phosphatase activity (IBA,ISO)

phosphatase activity (IEA)

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (IEA)

phosphatidylinositol-3,4,5-trisphosphate binding (ISO)

protein binding (ISO)

SH2 domain binding (IEA)

SH3 domain binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

References

Additional References at PubMed

PMID:12847108	PMID:14681463	PMID:21935613	PMID:22301074	PMID:31100035

Genomics

Comparative Map Data

INPPL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,793,069 - 6,808,028 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	6,793,971 - 6,807,286 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	7,554,374 - 7,570,176 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

INPPL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	72,223,563 - 72,239,147 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	72,223,701 - 72,239,147 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	71,935,811 - 71,950,191 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	71,613,473 - 71,627,797 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	71,613,472 - 71,627,796	NCBI
Celera	11	69,237,286 - 69,251,595 (+)	NCBI		Celera
Cytogenetic Map	11	q13.4	NCBI
HuRef	11	68,229,043 - 68,243,351 (+)	NCBI		HuRef
CHM1_1	11	71,819,333 - 71,833,642 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	72,149,924 - 72,165,764 (+)	NCBI		T2T-CHM13v2.0

Inppl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	101,471,839 - 101,487,419 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	101,471,839 - 101,487,436 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	101,822,632 - 101,838,226 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	101,822,632 - 101,838,229 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	108,971,146 - 108,986,740 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	101,696,482 - 101,711,897 (-)	NCBI		MGSCv36	mm8
Celera	7	102,194,349 - 102,209,965 (-)	NCBI		Celera
Cytogenetic Map	7	E2	NCBI
cM Map	7	54.67	NCBI

Inppl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,595,047 - 165,609,503 (-)	NCBI		GRCr8
mRatBN7.2	1	156,183,043 - 156,197,500 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,183,059 - 156,197,500 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,173,364 - 164,187,835 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,353,452 - 171,367,925 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,230,970 - 164,245,436 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	166,898,177 - 166,912,524 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	166,899,894 - 166,912,524 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,087,891 - 173,102,238 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,278,131 - 159,292,740 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	159,357,146 - 159,371,757 (-)	NCBI
Celera	1	154,261,664 - 154,276,489 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Inppl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	19,145,432 - 19,163,923 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	19,146,304 - 19,163,923 (-)	NCBI	ChiLan1.0	ChiLan1.0

INPPL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	73,170,486 - 73,186,205 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	74,213,883 - 74,229,609 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	67,302,066 - 67,317,785 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	70,527,525 - 70,540,623 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	70,527,017 - 70,540,846 (+)	Ensembl	panpan1.1		panPan2

INPPL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	25,900,308 - 25,914,527 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	25,900,900 - 25,915,577 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	25,670,004 - 25,684,057 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	26,108,942 - 26,122,997 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	26,108,951 - 26,124,170 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	25,900,410 - 25,914,476 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	26,116,609 - 26,130,663 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	26,018,164 - 26,032,213 (-)	NCBI		UU_Cfam_GSD_1.0

Inppl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	59,924,592 - 59,940,332 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	1,524,128 - 1,540,578 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	1,524,128 - 1,539,680 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INPPL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	63,443,819 - 63,459,067 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	63,444,713 - 63,459,776 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	62,425,383 - 62,440,788 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Inppl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	4,779,057 - 4,793,732 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	4,779,875 - 4,794,644 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in INPPL1
466 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001190279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK238949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP090889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01116481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU391030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000016162 ⟹ ENSSSCP00000015729

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	6,793,069 - 6,808,028 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000082421 ⟹ ENSSSCP00000069131

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	6,792,884 - 6,808,028 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000088713 ⟹ ENSSSCP00000074002

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	6,793,069 - 6,808,028 (+)	Ensembl

RefSeq Acc Id:

NM_001190279 ⟹ NP_001177208

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	6,793,971 - 6,807,286 (+)	NCBI

Sequence:

show sequence

ATGGCCTCCGCGTGCGGGGCGCCGGGCCCGGGGGGAGCGGGCCCGGGGGCCGCGCTGGGCAGCC
CGGCCCCCGCCTGGTACCACCGCGACCTGAGCCGGGCCGCCGCCGAGGAGCTGCTGGCCCGGGC
AGGCCGCGATGGCAGCTTCCTGGTCCGAGACAGCGAGAGCGTGGCAGGAGCCTTCGCGCTCTGC
GTCCTGTATCAGAAGCACGTGCACACGTATCGGATTCTACCTGATGGAGAAGACTTCCTGGCTG
TGCAGACCTCGCAGGGCGTGCCTGTGCGCCGCTTCCAGACCCTGGGGGAGCTCATCGGCCTGTA
CGCCCAACCCAACCAGGGCCTGGTGTGCGCCCTGCTGCTGCCTGTGGAGCGGGAGCGGGAGCTG
GACCCTCCGGATGAGCGGGACGCCTCAGATGGGGAGGATGAGAAGCCCCCACTGCCCCCTCGCT
CTGGTTCTACCAGCGTTTCTGCCCCCCTGGGGCCCAGCAGCCCCCCAGCAGCCCCTGAGACCCC
CCCGACTCCAGCTGTTGAGAGTGCTCCCAACGGGCTGAGCACCGTCTCGCACGAGTACCTGAAG
GGCAGCTACGGGCTGGACCTGGAGGCGGTGCGCGGCGGGGCCAGCAACCTGCCGCATCTCACCC
GCACGCTGGCCGCCTCGTGCCGGCGGCTGCACAGTGAGGTGGACAAGGTCCTGTCGGGCCTGGA
GATCCTGTCCAAGGTGTTTGACCAGCAGAGCTCGCCCATGGTGACCCGCCTCTTGCAGCAGCAG
AACCCACCCCAGACGGGGGAGCAGGAACTAGAGAGCCTGGTGCTGAAGCTGTCAGTGCTGAAGG
ACTTCCTGTCAGGCATCCAGAAGAAGGCCCTGAAGGCTCTCCAGGACATGAGTTCCACAGCGCC
CCCGGCCCCGGTGCAGCCGTCCACACGTAAGGCCAAGACCATCCCCGTGCAGGCCTTCGAGGTG
AAGCTGGATGTGACCCTGGGCGACCTGACCAAGATCGGGAAGTCGCAGAAGTTCACGCTGAGCG
TGGACGTGGAGGGCGGCCGGCTGGTGCTGCTGCGGCGACAGCGGGACTCGCAGGAGGACTGGAC
AACCTTCACGCACGACCGCATCCGCCAGCTCATTAAGTCCCAGCGGGTCCAGAACAAGCTGGGG
GTCGTGTTTGAGAAGGAGAAGGAGCGGACGCAGCGCAAGGACTTCATCTTCGTCAGCGCCCGGA
AGCGGGAGGCCTTCTGCCAGCTGCTGCAGCTCATGAAGAACAAGCACTCCAAGCAGGACGAGCC
CGACATGATCTCCGTCTTCATAGGCACCTGGAACATGGGAAGTGTGCCGCCTCCGAGAAACGTG
ACGTCTTGGTTCACCTCGAAGGGTCTGGGGAAGACCCTGGATGAGGTCACAGTGACCATACCCC
ATGACATCTATGTTTTTGGGACCCAGGAGAACTCGGTGGGCGACCGCGAGTGGCTGGACCTGCT
CCGTGGGGGCCTGAAGGAGCTCACAGACCTGGATTACCGCCCGATTGCCATGCAGTCGCTGTGG
AACATCAAGGTGGCTGTGCTGGTCAAGCCGGAGCACGAGAACCGCATCAGCCACGTCAGCACGT
CCAGCGTGAAGACGGGCATCGCCAACACCCTGGGAAATAAGGGGGCCGTGGGCGTCTCCTTCAT
GTTCAACGGCACCTCGTTCGGCTTTGTGAATTGCCACCTCACCTCGGGCAACGAGAAGACCGCC
CGGAGGAACCAGAACTACCTGGACATCCTGCGGCTGCTCTCGCTGGGCGACCGGCAGCTCGGCG
CCTTCGACATCTCCCTGCGGTTCACGCACCTCTTCTGGTTCGGGGACCTCAACTACCGCCTGGA
CATGGACATCCAGGAGATCCTCAACTACATCAGCCGGAAGGAGTTCGAGCCCCTGCTCCGGGTG
GACCAGCTCAACTTGGAGCGGGAGAAGCACAAGGTCTTCCTTCGGTTCAGTGAGGAGGAGATCT
CCTTCCCGCCCACCTACCGCTACGAGCGAGGTTCCCGGGACACGTACGCCTGGCACAAGCAGAA
GCCAACTGGGGTCCGCACCAACGTGCCTTCGTGGTGTGACCGGATTCTCTGGAAGTCCCACCCC
GAGACCCACATCATCTGCAACTCCTACGGCTGCACGGATGACATCGTCACCAGCGACCACTCCC
CCGTGTTTGGGACATTTGAGGTTGGAGTTACCTCTCAGTTCATCTCCAAGAAAGGGCTCTCAAA
GACGGCAGACCAGGCCTACATCGAGTTTGAGAGCATCGAGGCCATCGTGAAGACGGCCAGCCGC
ACTAAGTTCTTCATTGAGTTCTACTCCACCTGCCTGGAGGAGTACAAGAAGAGCTTCGAAAATG
ACGCCCAGAGCAGCGACAACGTCAACTTCCTTAAGGTGCAGTGGTCCTCACGCCAGCTGCCCAC
GCTCAAGCCCATTCTGGCCGACATTGAGTACCTGCAGGACCAGCACCTCCTGCTCACAGTCAAG
TCCATGGACGGCTACGAATCCTACGGAGAGTGCGTGGTGGCGCTCAAGTCCATGATTGGCAGCA
CGGCCCAGCAGTTCCTGACCTTCCTGTCCCACCGCGGCGAGGAGACGGGCAACATCCGAGGCTC
CATGAAGGTGCGGGTGCCCACCGAGCGCCTGGGCACCCGTGAGCGACTCTACGAGTGGATCAGC
ATCGATAAGGATGAGGCAGGAGCAAAGAGCAAAGCCCCGTCTGTGTCCCGAGGCAGCCAGGAGC
CCAGGTCAGGGAGCCGAAAGCCAGCCCCCGCAGAGGCCTCCTGCCCACTGTCGAAGTTATTTGA
GGAACCAGAGAAACCGCCACCAAATGGGAGGCCCCCGGCCCCACCTCGAGCTGCTCCCCGGGAG
GAGCCCCTGACCCCCAGGTTGAAGCCAGAGGGGGCTCCAGAGCCGGAAGGGGTGGCGGCCCCCC
CACCCAAGAACAGCTTCAATAACCCTGCCTACTACGTCCTTGAAGGGGTCCCACACCAGCTGCT
GCCCCCAGAGCCACCCTCGCCTGCCAGGGCCCCCGTCCCACCGGCCACCAAGAACAAAGTGGCC
ATCACAGTGCCTGCTCCACAGCTTGGGCGCCACCGGCCCCCCCGTGTGGGAGAGGGGAGCTCAT
CGGATGAGGAGTCTGGGGGCACACTGCCCCCTCCCGACTTCCCACCCCCGCCACTGCCGGATTC
AGCTATCTTCCTGCCCCCGAGCCGAGAGCCTCTGCCAGGGCCAGGGGTCCGGGGCCGCAGTGGG
GGTGAGGCCCGTGCCCTGCCACCTCCCAAGGCCCATCCAAGGCCCCCGCTGCCCCCTGGCCCCT
TGCCCCCGGGCACGTTCCTGGGGGAGGCGGCCGGCGGGGATGACCGCTCCTGCTCGGTGCTGCA
GGTGGCCAAGAAACTGAGTGAGGTGGACAGCGCCCCCCCGGGGCCCGGCCGCTGCCTGCTCCTG
CCAGGGCCCCTGGAGCTGCAGCCGGCCCGGGCACTGCCCTCGGACTACGGCCGGCCTCTCAGCT
TCCCTCCCCCGCGCATCCGAGAGAGCGTCCAGGAGGACCTGGCAGAGGAGGCTCCGTGCCCGCA
GGCCGGGCGGACCGGTGGGCTGGGCGAGGCGGGCATGGGCGCCTGGCTGCGGGCCATCGGCCTG
GAGCGCTACGAGGAGGGCCTGGTGCACAACGGCTGGGACGACCTGGAGTTTCTCAGCGACATCA
CCGAGGAGGATCTGGAGGAAGCTGGGGTGCAGGACCCGGCTCACAAGCGCCTCCTCCTGGACAC
GCTGCAGCTCAGCAAGTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001177208	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ADG23056	(Get FASTA)	NCBI Sequence Viewer
	D7PF45	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000074002
	ENSSSCP00000074002.1
	ENSSSCP00040035806.1
	ENSSSCP00050016115.1
	ENSSSCP00055041167.1
	ENSSSCP00060046483.1
	ENSSSCP00060046513.1

RefSeq Acc Id:

NP_001177208 ⟸ NM_001190279

- UniProtKB:

A0A480I2F7 (UniProtKB/TrEMBL), A0A8D1RT36 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASACGAPGPGGAGPGAALGSPAPAWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALC
VLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEREREL
DPPDERDASDGEDEKPPLPPRSGSTSVSAPLGPSSPPAAPETPPTPAVESAPNGLSTVSHEYLK
GSYGLDLEAVRGGASNLPHLTRTLAASCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQ
NPPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPVQPSTRKAKTIPVQAFEV
KLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLG
VVFEKEKERTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPRNV
TSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLW
NIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTA
RRNQNYLDILRLLSLGDRQLGAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRV
DQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSHP
ETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTADQAYIEFESIEAIVKTASR
TKFFIEFYSTCLEEYKKSFENDAQSSDNVNFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVK
SMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWIS
IDKDEAGAKSKAPSVSRGSQEPRSGSRKPAPAEASCPLSKLFEEPEKPPPNGRPPAPPRAAPRE
EPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPPATKNKVA
ITVPAPQLGRHRPPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSREPLPGPGVRGRSG
GEARALPPPKAHPRPPLPPGPLPPGTFLGEAAGGDDRSCSVLQVAKKLSEVDSAPPGPGRCLLL
PGPLELQPARALPSDYGRPLSFPPPRIRESVQEDLAEEAPCPQAGRTGGLGEAGMGAWLRAIGL
ERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK

hide sequence

Ensembl Acc Id:

ENSSSCP00000074002 ⟸ ENSSSCT00000088713

Ensembl Acc Id:

ENSSSCP00000015729 ⟸ ENSSSCT00000016162

Ensembl Acc Id:

ENSSSCP00000069131 ⟸ ENSSSCT00000082421

Protein Domains

SAM SH2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000014811	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00040060001	UniProtKB/TrEMBL
	ENSSSCG00050028935	UniProtKB/TrEMBL
	ENSSSCG00055025480	UniProtKB/TrEMBL
	ENSSSCG00060076105	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000088713	ENTREZGENE
	ENSSSCT00000088713.1	UniProtKB/TrEMBL
	ENSSSCT00040082253.1	UniProtKB/TrEMBL
	ENSSSCT00050038931.1	UniProtKB/TrEMBL
	ENSSSCT00055051505.1	UniProtKB/TrEMBL
	ENSSSCT00060105661.1	UniProtKB/TrEMBL
	ENSSSCT00060105710.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.60.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Endo/exonu/phosph_ase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IPPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:100462718	UniProtKB/Swiss-Prot
NCBI Gene	INPPL1	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2 DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Exo_endo_phos2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SAM_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	IPPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47769	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56219	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A480I2F7	ENTREZGENE, UniProtKB/TrEMBL
	A0A5G2RAE7_PIG	UniProtKB/TrEMBL
	A0A8D1M1W6_PIG	UniProtKB/TrEMBL
	A0A8D1RT36	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1WY24_PIG	UniProtKB/TrEMBL
	D7PF45	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	F1SUW7	UniProtKB/Swiss-Prot
VGNC ID	VGNC:89148	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)